-- dump date   	20140620_035401
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
992406000001	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
992406000002	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
992406000003	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
992406000004	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
992406000005	Substrate-binding site [chemical binding]; other site
992406000006	Substrate specificity [chemical binding]; other site
992406000007	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
992406000008	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
992406000009	DNA polymerase III, delta subunit; Region: holA; TIGR01128
992406000010	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
992406000011	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
992406000012	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
992406000013	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
992406000014	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
992406000015	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
992406000016	Predicted permeases [General function prediction only]; Region: COG0795
992406000017	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
992406000018	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
992406000019	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
992406000020	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
992406000021	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
992406000022	P-loop; other site
992406000023	Magnesium ion binding site [ion binding]; other site
992406000024	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
992406000025	Magnesium ion binding site [ion binding]; other site
992406000026	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
992406000027	ParB-like nuclease domain; Region: ParB; smart00470
992406000028	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
992406000029	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
992406000030	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
992406000031	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
992406000032	Catalytic site [active]
992406000033	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
992406000034	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
992406000035	WbqC-like protein family; Region: WbqC; pfam08889
992406000036	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
992406000037	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
992406000038	active site
992406000039	catalytic residues [active]
992406000040	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
992406000041	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
992406000042	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
992406000043	DNA binding residues [nucleotide binding]
992406000044	YceI-like domain; Region: YceI; pfam04264
992406000045	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
992406000046	active site
992406000047	homotetramer interface [polypeptide binding]; other site
992406000048	Domain of unknown function (DUF336); Region: DUF336; cl01249
992406000049	Domain of unknown function (DUF336); Region: DUF336; cl01249
992406000050	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
992406000051	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
992406000052	trmE is a tRNA modification GTPase; Region: trmE; cd04164
992406000053	G1 box; other site
992406000054	GTP/Mg2+ binding site [chemical binding]; other site
992406000055	Switch I region; other site
992406000056	G2 box; other site
992406000057	Switch II region; other site
992406000058	G3 box; other site
992406000059	G4 box; other site
992406000060	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
992406000061	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
992406000062	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
992406000063	ligand binding site [chemical binding]; other site
992406000064	flexible hinge region; other site
992406000065	aspartate aminotransferase; Provisional; Region: PRK05764
992406000066	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
992406000067	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406000068	homodimer interface [polypeptide binding]; other site
992406000069	catalytic residue [active]
992406000070	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
992406000071	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
992406000072	dimer interface [polypeptide binding]; other site
992406000073	decamer (pentamer of dimers) interface [polypeptide binding]; other site
992406000074	catalytic triad [active]
992406000075	peroxidatic and resolving cysteines [active]
992406000076	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
992406000077	catalytic residues [active]
992406000078	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
992406000079	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
992406000080	KpsF/GutQ family protein; Region: kpsF; TIGR00393
992406000081	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
992406000082	putative active site [active]
992406000083	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
992406000084	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
992406000085	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
992406000086	ATP binding site [chemical binding]; other site
992406000087	putative Mg++ binding site [ion binding]; other site
992406000088	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
992406000089	nucleotide binding region [chemical binding]; other site
992406000090	ATP-binding site [chemical binding]; other site
992406000091	RQC domain; Region: RQC; pfam09382
992406000092	HRDC domain; Region: HRDC; pfam00570
992406000093	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
992406000094	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
992406000095	putative ADP-binding pocket [chemical binding]; other site
992406000096	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
992406000097	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
992406000098	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
992406000099	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
992406000100	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258
992406000101	active site
992406000102	FlgD Ig-like domain; Region: FlgD_ig; pfam13860
992406000103	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
992406000104	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
992406000105	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
992406000106	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
992406000107	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
992406000108	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
992406000109	nudix motif; other site
992406000110	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
992406000111	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
992406000112	DNA polymerase III subunit delta'; Validated; Region: PRK08485
992406000113	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
992406000114	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
992406000115	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
992406000116	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
992406000117	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
992406000118	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
992406000119	ligand binding site [chemical binding]; other site
992406000120	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
992406000121	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
992406000122	FAD binding domain; Region: FAD_binding_4; pfam01565
992406000123	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
992406000124	active site
992406000125	oxyanion hole [active]
992406000126	catalytic triad [active]
992406000127	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
992406000128	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
992406000129	active site
992406000130	GTPase CgtA; Reviewed; Region: obgE; PRK12299
992406000131	GTP1/OBG; Region: GTP1_OBG; pfam01018
992406000132	Obg GTPase; Region: Obg; cd01898
992406000133	G1 box; other site
992406000134	GTP/Mg2+ binding site [chemical binding]; other site
992406000135	Switch I region; other site
992406000136	G2 box; other site
992406000137	G3 box; other site
992406000138	Switch II region; other site
992406000139	G4 box; other site
992406000140	G5 box; other site
992406000141	adenylate kinase; Reviewed; Region: adk; PRK00279
992406000142	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
992406000143	AMP-binding site [chemical binding]; other site
992406000144	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
992406000145	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
992406000146	active site
992406000147	CAAX protease self-immunity; Region: Abi; pfam02517
992406000148	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
992406000149	active site
992406000150	dimerization interface [polypeptide binding]; other site
992406000151	ribonuclease Z; Reviewed; Region: PRK00055
992406000152	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
992406000153	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
992406000154	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
992406000155	active site
992406000156	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
992406000157	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
992406000158	dimer interface [polypeptide binding]; other site
992406000159	active site
992406000160	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
992406000161	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
992406000162	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
992406000163	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
992406000164	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
992406000165	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
992406000166	substrate binding site [chemical binding]; other site
992406000167	oxyanion hole (OAH) forming residues; other site
992406000168	trimer interface [polypeptide binding]; other site
992406000169	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
992406000170	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
992406000171	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
992406000172	active site
992406000173	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
992406000174	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
992406000175	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
992406000176	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
992406000177	NAD(P) binding site [chemical binding]; other site
992406000178	active site
992406000179	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
992406000180	active site
992406000181	intersubunit interactions; other site
992406000182	catalytic residue [active]
992406000183	GTP-binding protein YchF; Reviewed; Region: PRK09601
992406000184	YchF GTPase; Region: YchF; cd01900
992406000185	G1 box; other site
992406000186	GTP/Mg2+ binding site [chemical binding]; other site
992406000187	Switch I region; other site
992406000188	G2 box; other site
992406000189	Switch II region; other site
992406000190	G3 box; other site
992406000191	G4 box; other site
992406000192	G5 box; other site
992406000193	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
992406000194	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
992406000195	Membrane protein of unknown function; Region: DUF360; pfam04020
992406000196	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
992406000197	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
992406000198	dimer interface [polypeptide binding]; other site
992406000199	active site
992406000200	CoA binding pocket [chemical binding]; other site
992406000201	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
992406000202	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
992406000203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406000204	S-adenosylmethionine binding site [chemical binding]; other site
992406000205	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
992406000206	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
992406000207	starch binding outer membrane protein SusD; Region: SusD; cl17845
992406000208	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
992406000209	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
992406000210	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
992406000211	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
992406000212	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
992406000213	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
992406000214	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
992406000215	phosphodiesterase YaeI; Provisional; Region: PRK11340
992406000216	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
992406000217	putative active site [active]
992406000218	putative metal binding site [ion binding]; other site
992406000219	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
992406000220	Transglycosylase; Region: Transgly; cl17702
992406000221	Site-specific recombinase; Region: SpecificRecomb; cl15411
992406000222	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
992406000223	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
992406000224	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
992406000225	starch binding outer membrane protein SusD; Region: SusD; cd08977
992406000226	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
992406000227	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
992406000228	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
992406000229	dihydrodipicolinate synthase; Region: dapA; TIGR00674
992406000230	dimer interface [polypeptide binding]; other site
992406000231	active site
992406000232	catalytic residue [active]
992406000233	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
992406000234	Uncharacterized subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u3; cd12832
992406000235	oligomer interface [polypeptide binding]; other site
992406000236	metal binding site [ion binding]; metal-binding site
992406000237	putative Cl binding site [ion binding]; other site
992406000238	basic sphincter; other site
992406000239	hydrophobic gate; other site
992406000240	periplasmic entrance; other site
992406000241	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
992406000242	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
992406000243	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
992406000244	FeoA domain; Region: FeoA; pfam04023
992406000245	NAD-dependent deacetylase; Provisional; Region: PRK00481
992406000246	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
992406000247	NAD+ binding site [chemical binding]; other site
992406000248	substrate binding site [chemical binding]; other site
992406000249	Zn binding site [ion binding]; other site
992406000250	Isochorismatase family; Region: Isochorismatase; pfam00857
992406000251	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
992406000252	catalytic triad [active]
992406000253	conserved cis-peptide bond; other site
992406000254	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
992406000255	MgtE intracellular N domain; Region: MgtE_N; smart00924
992406000256	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
992406000257	Divalent cation transporter; Region: MgtE; pfam01769
992406000258	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
992406000259	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
992406000260	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
992406000261	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
992406000262	FtsX-like permease family; Region: FtsX; pfam02687
992406000263	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
992406000264	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
992406000265	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
992406000266	UGMP family protein; Validated; Region: PRK09604
992406000267	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
992406000268	Family of unknown function (DUF490); Region: DUF490; pfam04357
992406000269	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
992406000270	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
992406000271	putative DNA binding site [nucleotide binding]; other site
992406000272	putative Zn2+ binding site [ion binding]; other site
992406000273	AsnC family; Region: AsnC_trans_reg; pfam01037
992406000274	Rrf2 family protein; Region: rrf2_super; TIGR00738
992406000275	Transcriptional regulator; Region: Rrf2; pfam02082
992406000276	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
992406000277	putative SAM binding site [chemical binding]; other site
992406000278	homodimer interface [polypeptide binding]; other site
992406000279	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
992406000280	Low molecular weight phosphatase family; Region: LMWPc; cd00115
992406000281	active site
992406000282	DnaA N-terminal domain; Region: DnaA_N; pfam11638
992406000283	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
992406000284	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406000285	Walker A motif; other site
992406000286	ATP binding site [chemical binding]; other site
992406000287	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
992406000288	Walker B motif; other site
992406000289	arginine finger; other site
992406000290	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
992406000291	DnaA box-binding interface [nucleotide binding]; other site
992406000292	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
992406000293	active site
992406000294	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
992406000295	active site pocket [active]
992406000296	oxyanion hole [active]
992406000297	catalytic triad [active]
992406000298	active site nucleophile [active]
992406000299	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
992406000300	amino acid transporter; Region: 2A0306; TIGR00909
992406000301	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
992406000302	HD domain; Region: HD_4; pfam13328
992406000303	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
992406000304	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
992406000305	RNA binding surface [nucleotide binding]; other site
992406000306	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
992406000307	probable active site [active]
992406000308	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
992406000309	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
992406000310	RNA binding site [nucleotide binding]; other site
992406000311	active site
992406000312	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
992406000313	putative nucleotide binding site [chemical binding]; other site
992406000314	uridine monophosphate binding site [chemical binding]; other site
992406000315	homohexameric interface [polypeptide binding]; other site
992406000316	ribosome recycling factor; Reviewed; Region: frr; PRK00083
992406000317	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
992406000318	hinge region; other site
992406000319	lysine-specific histone demethylase 1 homolog; Region: PLN02328
992406000320	Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255
992406000321	ERF superfamily; Region: ERF; pfam04404
992406000322	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
992406000323	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752
992406000324	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
992406000325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406000326	S-adenosylmethionine binding site [chemical binding]; other site
992406000327	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
992406000328	Ligand Binding Site [chemical binding]; other site
992406000329	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540
992406000330	putative metal binding site [ion binding]; other site
992406000331	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
992406000332	AntA/AntB antirepressor; Region: AntA; pfam08346
992406000333	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
992406000334	Protein of unknown function (DUF2693); Region: DUF2693; pfam10902
992406000335	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
992406000336	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
992406000337	Ligand Binding Site [chemical binding]; other site
992406000338	Phage terminase large subunit; Region: Terminase_3; cl12054
992406000339	Terminase-like family; Region: Terminase_6; pfam03237
992406000340	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
992406000341	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
992406000342	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
992406000343	AntA/AntB antirepressor; Region: AntA; cl01430
992406000344	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
992406000345	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
992406000346	tape measure domain; Region: tape_meas_nterm; TIGR02675
992406000347	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
992406000348	salt bridge; other site
992406000349	non-specific DNA binding site [nucleotide binding]; other site
992406000350	sequence-specific DNA binding site [nucleotide binding]; other site
992406000351	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
992406000352	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
992406000353	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
992406000354	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
992406000355	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
992406000356	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
992406000357	active site
992406000358	metal binding site [ion binding]; metal-binding site
992406000359	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
992406000360	non-specific DNA binding site [nucleotide binding]; other site
992406000361	salt bridge; other site
992406000362	sequence-specific DNA binding site [nucleotide binding]; other site
992406000363	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
992406000364	sequence-specific DNA binding site [nucleotide binding]; other site
992406000365	salt bridge; other site
992406000366	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
992406000367	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
992406000368	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
992406000369	active site
992406000370	catalytic residues [active]
992406000371	DNA binding site [nucleotide binding]
992406000372	Int/Topo IB signature motif; other site
992406000373	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
992406000374	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
992406000375	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
992406000376	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
992406000377	GH3 auxin-responsive promoter; Region: GH3; pfam03321
992406000378	H+ Antiporter protein; Region: 2A0121; TIGR00900
992406000379	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
992406000380	putative substrate translocation pore; other site
992406000381	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
992406000382	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
992406000383	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
992406000384	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
992406000385	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
992406000386	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
992406000387	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
992406000388	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
992406000389	TrkA-N domain; Region: TrkA_N; pfam02254
992406000390	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
992406000391	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
992406000392	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
992406000393	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
992406000394	DNA binding residues [nucleotide binding]
992406000395	Bifunctional nuclease; Region: DNase-RNase; pfam02577
992406000396	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
992406000397	Ligand binding site [chemical binding]; other site
992406000398	Electron transfer flavoprotein domain; Region: ETF; pfam01012
992406000399	short chain dehydrogenase; Provisional; Region: PRK07326
992406000400	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
992406000401	NAD(P) binding site [chemical binding]; other site
992406000402	active site
992406000403	Protein of unknown function (DUF3822); Region: DUF3822; pfam12864
992406000404	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
992406000405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406000406	S-adenosylmethionine binding site [chemical binding]; other site
992406000407	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
992406000408	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
992406000409	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
992406000410	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406000411	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
992406000412	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
992406000413	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
992406000414	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
992406000415	Walker A/P-loop; other site
992406000416	ATP binding site [chemical binding]; other site
992406000417	Q-loop/lid; other site
992406000418	ABC transporter signature motif; other site
992406000419	Walker B; other site
992406000420	D-loop; other site
992406000421	H-loop/switch region; other site
992406000422	lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598
992406000423	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
992406000424	Sulfatase; Region: Sulfatase; pfam00884
992406000425	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
992406000426	active site
992406000427	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
992406000428	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
992406000429	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
992406000430	hexamer interface [polypeptide binding]; other site
992406000431	ligand binding site [chemical binding]; other site
992406000432	putative active site [active]
992406000433	NAD(P) binding site [chemical binding]; other site
992406000434	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
992406000435	prephenate dehydrogenase; Validated; Region: PRK08507
992406000436	Prephenate dehydrogenase; Region: PDH; pfam02153
992406000437	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
992406000438	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
992406000439	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
992406000440	TrkA-N domain; Region: TrkA_N; pfam02254
992406000441	TrkA-C domain; Region: TrkA_C; pfam02080
992406000442	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
992406000443	putative active site [active]
992406000444	putative CoA binding site [chemical binding]; other site
992406000445	nudix motif; other site
992406000446	metal binding site [ion binding]; metal-binding site
992406000447	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
992406000448	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
992406000449	putative acyl-acceptor binding pocket; other site
992406000450	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
992406000451	recombination factor protein RarA; Reviewed; Region: PRK13342
992406000452	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406000453	Walker A motif; other site
992406000454	ATP binding site [chemical binding]; other site
992406000455	Walker B motif; other site
992406000456	arginine finger; other site
992406000457	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
992406000458	Haemolytic domain; Region: Haemolytic; pfam01809
992406000459	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
992406000460	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
992406000461	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
992406000462	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
992406000463	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
992406000464	catalytic residue [active]
992406000465	Response regulator receiver domain; Region: Response_reg; pfam00072
992406000466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
992406000467	active site
992406000468	phosphorylation site [posttranslational modification]
992406000469	intermolecular recognition site; other site
992406000470	dimerization interface [polypeptide binding]; other site
992406000471	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406000472	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
992406000473	Walker A motif; other site
992406000474	ATP binding site [chemical binding]; other site
992406000475	Walker B motif; other site
992406000476	arginine finger; other site
992406000477	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
992406000478	multidrug efflux protein; Reviewed; Region: PRK01766
992406000479	cation binding site [ion binding]; other site
992406000480	peptide chain release factor 2; Validated; Region: prfB; PRK00578
992406000481	PCRF domain; Region: PCRF; pfam03462
992406000482	RF-1 domain; Region: RF-1; pfam00472
992406000483	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
992406000484	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
992406000485	DNA primase, catalytic core; Region: dnaG; TIGR01391
992406000486	CHC2 zinc finger; Region: zf-CHC2; pfam01807
992406000487	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
992406000488	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
992406000489	active site
992406000490	metal binding site [ion binding]; metal-binding site
992406000491	interdomain interaction site; other site
992406000492	Clp protease; Region: CLP_protease; pfam00574
992406000493	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
992406000494	oligomer interface [polypeptide binding]; other site
992406000495	active site residues [active]
992406000496	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
992406000497	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
992406000498	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406000499	Walker A motif; other site
992406000500	ATP binding site [chemical binding]; other site
992406000501	Walker B motif; other site
992406000502	arginine finger; other site
992406000503	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
992406000504	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861
992406000505	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
992406000506	metal binding triad [ion binding]; metal-binding site
992406000507	Restriction endonuclease; Region: Mrr_cat; pfam04471
992406000508	PIN domain; Region: PIN_3; cl17397
992406000509	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
992406000510	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
992406000511	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
992406000512	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
992406000513	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
992406000514	non-specific DNA binding site [nucleotide binding]; other site
992406000515	salt bridge; other site
992406000516	sequence-specific DNA binding site [nucleotide binding]; other site
992406000517	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
992406000518	Heavy-metal-associated domain; Region: HMA; pfam00403
992406000519	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
992406000520	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
992406000521	non-specific DNA binding site [nucleotide binding]; other site
992406000522	salt bridge; other site
992406000523	sequence-specific DNA binding site [nucleotide binding]; other site
992406000524	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
992406000525	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
992406000526	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
992406000527	Multicopper oxidase; Region: Cu-oxidase; pfam00394
992406000528	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
992406000529	Helix-turn-helix domain; Region: HTH_18; pfam12833
992406000530	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
992406000531	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
992406000532	metal-binding site [ion binding]
992406000533	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
992406000534	Sel1 repeat; Region: Sel1; cl02723
992406000535	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
992406000536	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
992406000537	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406000538	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
992406000539	DNA methylase; Region: N6_N4_Mtase; pfam01555
992406000540	DpnII restriction endonuclease; Region: DpnII; pfam04556
992406000541	DNA adenine methylase (dam); Region: dam; TIGR00571
992406000542	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
992406000543	oligomeric interface; other site
992406000544	putative active site [active]
992406000545	homodimer interface [polypeptide binding]; other site
992406000546	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
992406000547	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406000548	Heavy-metal-associated domain; Region: HMA; pfam00403
992406000549	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
992406000550	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
992406000551	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
992406000552	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
992406000553	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
992406000554	hypothetical protein; Provisional; Region: PRK07236
992406000555	hypothetical protein; Validated; Region: PRK05868
992406000556	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
992406000557	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
992406000558	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
992406000559	MepB protein; Region: MepB; cl01985
992406000560	hypothetical protein; Provisional; Region: PRK07236
992406000561	FAD binding domain; Region: FAD_binding_3; pfam01494
992406000562	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
992406000563	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
992406000564	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
992406000565	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406000566	aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340
992406000567	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584
992406000568	substrate binding site [chemical binding]; other site
992406000569	ligand binding site [chemical binding]; other site
992406000570	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
992406000571	substrate binding site [chemical binding]; other site
992406000572	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
992406000573	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
992406000574	active site
992406000575	NTP binding site [chemical binding]; other site
992406000576	metal binding triad [ion binding]; metal-binding site
992406000577	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
992406000578	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
992406000579	Zn2+ binding site [ion binding]; other site
992406000580	Mg2+ binding site [ion binding]; other site
992406000581	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
992406000582	The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843
992406000583	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
992406000584	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
992406000585	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
992406000586	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
992406000587	AAA domain; Region: AAA_26; pfam13500
992406000588	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
992406000589	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
992406000590	active site
992406000591	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
992406000592	FAD binding site [chemical binding]; other site
992406000593	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
992406000594	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
992406000595	substrate binding pocket [chemical binding]; other site
992406000596	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
992406000597	B12 binding site [chemical binding]; other site
992406000598	cobalt ligand [ion binding]; other site
992406000599	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
992406000600	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
992406000601	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
992406000602	Proline dehydrogenase; Region: Pro_dh; cl03282
992406000603	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
992406000604	active site
992406000605	dimer interface [polypeptide binding]; other site
992406000606	metal binding site [ion binding]; metal-binding site
992406000607	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
992406000608	Oxygen tolerance; Region: BatD; pfam13584
992406000609	Oxygen tolerance; Region: BatD; pfam13584
992406000610	Oxygen tolerance; Region: BatD; pfam13584
992406000611	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
992406000612	binding surface
992406000613	Tetratricopeptide repeat; Region: TPR_12; pfam13424
992406000614	TPR motif; other site
992406000615	TPR repeat; Region: TPR_11; pfam13414
992406000616	von Willebrand factor type A domain; Region: VWA_2; pfam13519
992406000617	metal ion-dependent adhesion site (MIDAS); other site
992406000618	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
992406000619	metal ion-dependent adhesion site (MIDAS); other site
992406000620	Oxygen tolerance; Region: BatD; pfam13584
992406000621	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
992406000622	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
992406000623	metal ion-dependent adhesion site (MIDAS); other site
992406000624	MoxR-like ATPases [General function prediction only]; Region: COG0714
992406000625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406000626	Walker A motif; other site
992406000627	ATP binding site [chemical binding]; other site
992406000628	Walker B motif; other site
992406000629	arginine finger; other site
992406000630	DinB superfamily; Region: DinB_2; pfam12867
992406000631	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
992406000632	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
992406000633	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
992406000634	TraB family; Region: TraB; cl12050
992406000635	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
992406000636	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
992406000637	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
992406000638	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
992406000639	Substrate binding site [chemical binding]; other site
992406000640	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
992406000641	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406000642	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
992406000643	N-terminal plug; other site
992406000644	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
992406000645	ligand-binding site [chemical binding]; other site
992406000646	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
992406000647	Imelysin; Region: Peptidase_M75; pfam09375
992406000648	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406000649	Domain of unknown function (DUF4302); Region: DUF4302; pfam14135
992406000650	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
992406000651	starch binding outer membrane protein SusD; Region: SusD; cl17845
992406000652	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
992406000653	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
992406000654	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406000655	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
992406000656	amino acid transporter; Region: 2A0306; TIGR00909
992406000657	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
992406000658	Predicted transcriptional regulator [Transcription]; Region: COG2378
992406000659	WYL domain; Region: WYL; pfam13280
992406000660	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
992406000661	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
992406000662	tetramer interface [polypeptide binding]; other site
992406000663	TPP-binding site [chemical binding]; other site
992406000664	heterodimer interface [polypeptide binding]; other site
992406000665	phosphorylation loop region [posttranslational modification]
992406000666	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
992406000667	E3 interaction surface; other site
992406000668	lipoyl attachment site [posttranslational modification]; other site
992406000669	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
992406000670	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
992406000671	E3 interaction surface; other site
992406000672	lipoyl attachment site [posttranslational modification]; other site
992406000673	e3 binding domain; Region: E3_binding; pfam02817
992406000674	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
992406000675	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
992406000676	intersubunit interface [polypeptide binding]; other site
992406000677	active site
992406000678	catalytic residue [active]
992406000679	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
992406000680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
992406000681	putative substrate translocation pore; other site
992406000682	POT family; Region: PTR2; cl17359
992406000683	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
992406000684	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
992406000685	putative active site [active]
992406000686	putative metal binding site [ion binding]; other site
992406000687	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
992406000688	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
992406000689	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
992406000690	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
992406000691	SusD family; Region: SusD; pfam07980
992406000692	potential frameshift: common BLAST hit: gi|383486530|ref|YP_005395442.1| alkaline phosphatase
992406000693	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577
992406000694	putative active site [active]
992406000695	catalytic site [active]
992406000696	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
992406000697	dimer interface [polypeptide binding]; other site
992406000698	active site
992406000699	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
992406000700	putative catalytic site [active]
992406000701	putative metal binding site [ion binding]; other site
992406000702	putative phosphate binding site [ion binding]; other site
992406000703	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
992406000704	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
992406000705	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
992406000706	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
992406000707	ATP binding site [chemical binding]; other site
992406000708	putative Mg++ binding site [ion binding]; other site
992406000709	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
992406000710	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
992406000711	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
992406000712	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
992406000713	HsdM N-terminal domain; Region: HsdM_N; pfam12161
992406000714	Methyltransferase domain; Region: Methyltransf_26; pfam13659
992406000715	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
992406000716	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
992406000717	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
992406000718	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
992406000719	M28 Zn-Peptidases; Region: M28_like_4; cd08015
992406000720	Peptidase family M28; Region: Peptidase_M28; pfam04389
992406000721	metal binding site [ion binding]; metal-binding site
992406000722	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
992406000723	starch binding outer membrane protein SusD; Region: SusD; cd08977
992406000724	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
992406000725	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
992406000726	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
992406000727	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
992406000728	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
992406000729	ATP binding site [chemical binding]; other site
992406000730	putative Mg++ binding site [ion binding]; other site
992406000731	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
992406000732	Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690
992406000733	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
992406000734	GAF domain; Region: GAF_2; pfam13185
992406000735	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
992406000736	putative hydrolase; Provisional; Region: PRK02113
992406000737	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
992406000738	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
992406000739	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
992406000740	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
992406000741	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
992406000742	inhibitor-cofactor binding pocket; inhibition site
992406000743	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406000744	catalytic residue [active]
992406000745	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
992406000746	LysM domain; Region: LysM; pfam01476
992406000747	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
992406000748	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
992406000749	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
992406000750	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
992406000751	catalytic residue [active]
992406000752	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
992406000753	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
992406000754	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
992406000755	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
992406000756	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
992406000757	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
992406000758	ligand binding site [chemical binding]; other site
992406000759	active site
992406000760	UGI interface [polypeptide binding]; other site
992406000761	catalytic site [active]
992406000762	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
992406000763	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
992406000764	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
992406000765	homodimer interface [polypeptide binding]; other site
992406000766	substrate-cofactor binding pocket; other site
992406000767	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406000768	catalytic residue [active]
992406000769	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
992406000770	active site
992406000771	multimer interface [polypeptide binding]; other site
992406000772	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
992406000773	gamma subunit interface [polypeptide binding]; other site
992406000774	LBP interface [polypeptide binding]; other site
992406000775	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
992406000776	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
992406000777	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
992406000778	alpha subunit interaction interface [polypeptide binding]; other site
992406000779	Walker A motif; other site
992406000780	ATP binding site [chemical binding]; other site
992406000781	Walker B motif; other site
992406000782	inhibitor binding site; inhibition site
992406000783	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
992406000784	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
992406000785	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
992406000786	active site
992406000787	Riboflavin kinase; Region: Flavokinase; pfam01687
992406000788	Protein of unknown function (DUF419); Region: DUF419; pfam04237
992406000789	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
992406000790	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
992406000791	putative active site [active]
992406000792	Mn binding site [ion binding]; other site
992406000793	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
992406000794	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
992406000795	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
992406000796	dimer interface [polypeptide binding]; other site
992406000797	active site
992406000798	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
992406000799	catalytic residues [active]
992406000800	substrate binding site [chemical binding]; other site
992406000801	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
992406000802	Thiamine pyrophosphokinase; Region: TPK; cd07995
992406000803	active site
992406000804	dimerization interface [polypeptide binding]; other site
992406000805	thiamine binding site [chemical binding]; other site
992406000806	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
992406000807	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
992406000808	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
992406000809	Walker A/P-loop; other site
992406000810	ATP binding site [chemical binding]; other site
992406000811	Q-loop/lid; other site
992406000812	ABC transporter signature motif; other site
992406000813	Walker B; other site
992406000814	D-loop; other site
992406000815	H-loop/switch region; other site
992406000816	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
992406000817	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
992406000818	ligand binding site [chemical binding]; other site
992406000819	flexible hinge region; other site
992406000820	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
992406000821	non-specific DNA interactions [nucleotide binding]; other site
992406000822	DNA binding site [nucleotide binding]
992406000823	sequence specific DNA binding site [nucleotide binding]; other site
992406000824	putative cAMP binding site [chemical binding]; other site
992406000825	chorismate binding enzyme; Region: Chorismate_bind; cl10555
992406000826	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
992406000827	CoenzymeA binding site [chemical binding]; other site
992406000828	subunit interaction site [polypeptide binding]; other site
992406000829	PHB binding site; other site
992406000830	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
992406000831	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
992406000832	putative acyl-acceptor binding pocket; other site
992406000833	PspC domain; Region: PspC; pfam04024
992406000834	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
992406000835	Predicted transcriptional regulators [Transcription]; Region: COG1695
992406000836	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
992406000837	putative Zn2+ binding site [ion binding]; other site
992406000838	putative DNA binding site [nucleotide binding]; other site
992406000839	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
992406000840	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
992406000841	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
992406000842	Thioesterase domain; Region: Thioesterase; pfam00975
992406000843	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
992406000844	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
992406000845	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406000846	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
992406000847	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
992406000848	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
992406000849	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
992406000850	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
992406000851	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
992406000852	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
992406000853	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
992406000854	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
992406000855	ApbE family; Region: ApbE; pfam02424
992406000856	Uncharacterized conserved protein [Function unknown]; Region: COG1739
992406000857	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
992406000858	Rrf2 family protein; Region: rrf2_super; TIGR00738
992406000859	Transcriptional regulator; Region: Rrf2; pfam02082
992406000860	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
992406000861	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
992406000862	Hemerythrin-like domain; Region: Hr-like; cd12108
992406000863	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
992406000864	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
992406000865	ligand binding site [chemical binding]; other site
992406000866	flexible hinge region; other site
992406000867	Domain of unknown function DUF77; Region: DUF77; cl00307
992406000868	Cytochrome c; Region: Cytochrom_C; cl11414
992406000869	Cytochrome c; Region: Cytochrom_C; pfam00034
992406000870	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
992406000871	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
992406000872	NosL; Region: NosL; cl01769
992406000873	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
992406000874	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
992406000875	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
992406000876	Walker A/P-loop; other site
992406000877	ATP binding site [chemical binding]; other site
992406000878	ABC transporter; Region: ABC_tran; pfam00005
992406000879	Q-loop/lid; other site
992406000880	ABC transporter signature motif; other site
992406000881	Walker B; other site
992406000882	D-loop; other site
992406000883	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cl00178
992406000884	secondary substrate binding site; other site
992406000885	primary substrate binding site; other site
992406000886	inhibition loop; other site
992406000887	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
992406000888	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
992406000889	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
992406000890	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
992406000891	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
992406000892	DNA binding residues [nucleotide binding]
992406000893	Pirin-related protein [General function prediction only]; Region: COG1741
992406000894	Pirin; Region: Pirin; pfam02678
992406000895	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
992406000896	Response regulator receiver domain; Region: Response_reg; pfam00072
992406000897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
992406000898	active site
992406000899	phosphorylation site [posttranslational modification]
992406000900	intermolecular recognition site; other site
992406000901	dimerization interface [polypeptide binding]; other site
992406000902	PglZ domain; Region: PglZ; pfam08665
992406000903	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
992406000904	catalytic motif [active]
992406000905	Zn binding site [ion binding]; other site
992406000906	RibD C-terminal domain; Region: RibD_C; cl17279
992406000907	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
992406000908	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
992406000909	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
992406000910	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
992406000911	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
992406000912	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
992406000913	shikimate binding site; other site
992406000914	NAD(P) binding site [chemical binding]; other site
992406000915	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
992406000916	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
992406000917	homodimer interface [polypeptide binding]; other site
992406000918	metal binding site [ion binding]; metal-binding site
992406000919	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
992406000920	homodimer interface [polypeptide binding]; other site
992406000921	active site
992406000922	putative chemical substrate binding site [chemical binding]; other site
992406000923	metal binding site [ion binding]; metal-binding site
992406000924	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
992406000925	active site
992406000926	catalytic residues [active]
992406000927	metal binding site [ion binding]; metal-binding site
992406000928	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
992406000929	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
992406000930	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
992406000931	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
992406000932	ATP binding site [chemical binding]; other site
992406000933	putative Mg++ binding site [ion binding]; other site
992406000934	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
992406000935	nucleotide binding region [chemical binding]; other site
992406000936	ATP-binding site [chemical binding]; other site
992406000937	TRCF domain; Region: TRCF; pfam03461
992406000938	YceI-like domain; Region: YceI; pfam04264
992406000939	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
992406000940	dimer interface [polypeptide binding]; other site
992406000941	phosphorylation site [posttranslational modification]
992406000942	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
992406000943	ATP binding site [chemical binding]; other site
992406000944	Mg2+ binding site [ion binding]; other site
992406000945	G-X-G motif; other site
992406000946	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
992406000947	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
992406000948	active site
992406000949	phosphorylation site [posttranslational modification]
992406000950	intermolecular recognition site; other site
992406000951	dimerization interface [polypeptide binding]; other site
992406000952	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
992406000953	DNA binding site [nucleotide binding]
992406000954	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
992406000955	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
992406000956	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406000957	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
992406000958	gliding motility associated protien GldN; Region: GldN; TIGR03523
992406000959	gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517
992406000960	GldM N-terminal domain; Region: GldM_N; pfam12081
992406000961	GldM C-terminal domain; Region: GldM_C; pfam12080
992406000962	gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513
992406000963	gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525
992406000964	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
992406000965	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
992406000966	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
992406000967	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
992406000968	glutaminase active site [active]
992406000969	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
992406000970	dimer interface [polypeptide binding]; other site
992406000971	active site
992406000972	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
992406000973	dimer interface [polypeptide binding]; other site
992406000974	active site
992406000975	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
992406000976	Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323
992406000977	Pantoate-beta-alanine ligase; Region: PanC; cd00560
992406000978	pantoate--beta-alanine ligase; Region: panC; TIGR00018
992406000979	active site
992406000980	ATP-binding site [chemical binding]; other site
992406000981	pantoate-binding site; other site
992406000982	HXXH motif; other site
992406000983	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
992406000984	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
992406000985	HemN C-terminal domain; Region: HemN_C; pfam06969
992406000986	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
992406000987	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
992406000988	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
992406000989	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
992406000990	dimer interface [polypeptide binding]; other site
992406000991	motif 1; other site
992406000992	active site
992406000993	motif 2; other site
992406000994	motif 3; other site
992406000995	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
992406000996	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
992406000997	Walker A/P-loop; other site
992406000998	ATP binding site [chemical binding]; other site
992406000999	Q-loop/lid; other site
992406001000	ABC transporter signature motif; other site
992406001001	Walker B; other site
992406001002	D-loop; other site
992406001003	H-loop/switch region; other site
992406001004	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
992406001005	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
992406001006	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
992406001007	Walker A/P-loop; other site
992406001008	ATP binding site [chemical binding]; other site
992406001009	Q-loop/lid; other site
992406001010	ABC transporter signature motif; other site
992406001011	Walker B; other site
992406001012	D-loop; other site
992406001013	H-loop/switch region; other site
992406001014	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
992406001015	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
992406001016	dimerization interface 3.5A [polypeptide binding]; other site
992406001017	active site
992406001018	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
992406001019	active site
992406001020	metal binding site [ion binding]; metal-binding site
992406001021	homotetramer interface [polypeptide binding]; other site
992406001022	Smr domain; Region: Smr; cl02619
992406001023	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
992406001024	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
992406001025	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
992406001026	dimer interface [polypeptide binding]; other site
992406001027	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406001028	catalytic residue [active]
992406001029	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
992406001030	trimer interface [polypeptide binding]; other site
992406001031	active site
992406001032	substrate binding site [chemical binding]; other site
992406001033	CoA binding site [chemical binding]; other site
992406001034	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
992406001035	gliding motility-associated protein GldC; Region: GldC; TIGR03515
992406001036	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
992406001037	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
992406001038	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
992406001039	homodimer interface [polypeptide binding]; other site
992406001040	NAD binding pocket [chemical binding]; other site
992406001041	ATP binding pocket [chemical binding]; other site
992406001042	Mg binding site [ion binding]; other site
992406001043	active-site loop [active]
992406001044	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
992406001045	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
992406001046	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
992406001047	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
992406001048	inhibitor-cofactor binding pocket; inhibition site
992406001049	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406001050	catalytic residue [active]
992406001051	OstA-like protein; Region: OstA; cl00844
992406001052	OstA-like protein; Region: OstA_2; pfam13100
992406001053	OstA-like protein; Region: OstA; cl00844
992406001054	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
992406001055	metal binding site 2 [ion binding]; metal-binding site
992406001056	putative DNA binding helix; other site
992406001057	metal binding site 1 [ion binding]; metal-binding site
992406001058	dimer interface [polypeptide binding]; other site
992406001059	structural Zn2+ binding site [ion binding]; other site
992406001060	K+ potassium transporter; Region: K_trans; pfam02705
992406001061	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
992406001062	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
992406001063	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
992406001064	active site
992406001065	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
992406001066	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
992406001067	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
992406001068	putative substrate translocation pore; other site
992406001069	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
992406001070	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406001071	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
992406001072	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406001073	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
992406001074	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
992406001075	nucleotide binding pocket [chemical binding]; other site
992406001076	K-X-D-G motif; other site
992406001077	catalytic site [active]
992406001078	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
992406001079	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
992406001080	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
992406001081	Dimer interface [polypeptide binding]; other site
992406001082	BRCT sequence motif; other site
992406001083	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
992406001084	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
992406001085	non-specific DNA binding site [nucleotide binding]; other site
992406001086	salt bridge; other site
992406001087	sequence-specific DNA binding site [nucleotide binding]; other site
992406001088	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
992406001089	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
992406001090	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
992406001091	ATPase involved in DNA repair; Region: DUF3686; pfam12458
992406001092	AAA domain; Region: AAA_22; pfam13401
992406001093	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406001094	Walker A motif; other site
992406001095	ATP binding site [chemical binding]; other site
992406001096	Walker B motif; other site
992406001097	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
992406001098	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
992406001099	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
992406001100	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
992406001101	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
992406001102	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
992406001103	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
992406001104	RHS Repeat; Region: RHS_repeat; pfam05593
992406001105	RHS Repeat; Region: RHS_repeat; cl11982
992406001106	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
992406001107	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406001108	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
992406001109	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
992406001110	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
992406001111	Peptidase family M23; Region: Peptidase_M23; pfam01551
992406001112	Protein of unknown function (DUF2459); Region: DUF2459; pfam09601
992406001113	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
992406001114	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
992406001115	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
992406001116	active site residue [active]
992406001117	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
992406001118	Coenzyme A binding pocket [chemical binding]; other site
992406001119	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
992406001120	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
992406001121	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
992406001122	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
992406001123	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406001124	S-adenosylmethionine binding site [chemical binding]; other site
992406001125	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
992406001126	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
992406001127	FtsX-like permease family; Region: FtsX; pfam02687
992406001128	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
992406001129	Predicted membrane protein [Function unknown]; Region: COG2860
992406001130	UPF0126 domain; Region: UPF0126; pfam03458
992406001131	UPF0126 domain; Region: UPF0126; pfam03458
992406001132	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
992406001133	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
992406001134	active site
992406001135	(T/H)XGH motif; other site
992406001136	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
992406001137	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
992406001138	ATP-grasp domain; Region: ATP-grasp_4; cl17255
992406001139	homoserine O-acetyltransferase; Provisional; Region: PRK06765
992406001140	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
992406001141	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
992406001142	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
992406001143	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
992406001144	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
992406001145	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
992406001146	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
992406001147	homodimer interface [polypeptide binding]; other site
992406001148	substrate-cofactor binding pocket; other site
992406001149	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406001150	catalytic residue [active]
992406001151	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
992406001152	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
992406001153	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179
992406001154	putative ligand binding site [chemical binding]; other site
992406001155	putative NAD binding site [chemical binding]; other site
992406001156	catalytic site [active]
992406001157	Beta-lactamase; Region: Beta-lactamase; pfam00144
992406001158	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
992406001159	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
992406001160	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
992406001161	CoA-ligase; Region: Ligase_CoA; pfam00549
992406001162	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
992406001163	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
992406001164	homodimer interface [polypeptide binding]; other site
992406001165	catalytic residues [active]
992406001166	NAD binding site [chemical binding]; other site
992406001167	substrate binding pocket [chemical binding]; other site
992406001168	flexible flap; other site
992406001169	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
992406001170	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
992406001171	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
992406001172	dimerization interface [polypeptide binding]; other site
992406001173	active site
992406001174	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
992406001175	putative recombination protein RecB; Provisional; Region: PRK13909
992406001176	Part of AAA domain; Region: AAA_19; pfam13245
992406001177	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
992406001178	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
992406001179	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
992406001180	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
992406001181	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
992406001182	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
992406001183	RNA binding surface [nucleotide binding]; other site
992406001184	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
992406001185	active site
992406001186	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
992406001187	starch binding outer membrane protein SusD; Region: SusD; cd08977
992406001188	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
992406001189	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
992406001190	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
992406001191	active site
992406001192	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
992406001193	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
992406001194	homodimer interface [polypeptide binding]; other site
992406001195	oligonucleotide binding site [chemical binding]; other site
992406001196	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
992406001197	IHF dimer interface [polypeptide binding]; other site
992406001198	IHF - DNA interface [nucleotide binding]; other site
992406001199	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
992406001200	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
992406001201	minor groove reading motif; other site
992406001202	helix-hairpin-helix signature motif; other site
992406001203	substrate binding pocket [chemical binding]; other site
992406001204	active site
992406001205	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
992406001206	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
992406001207	DNA binding and oxoG recognition site [nucleotide binding]
992406001208	gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512
992406001209	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
992406001210	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
992406001211	substrate binding site [chemical binding]; other site
992406001212	ATP binding site [chemical binding]; other site
992406001213	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
992406001214	SurA N-terminal domain; Region: SurA_N; pfam09312
992406001215	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
992406001216	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
992406001217	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
992406001218	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
992406001219	motif 1; other site
992406001220	active site
992406001221	motif 2; other site
992406001222	motif 3; other site
992406001223	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
992406001224	glucokinase, proteobacterial type; Region: glk; TIGR00749
992406001225	Glucokinase; Region: Glucokinase; pfam02685
992406001226	The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843
992406001227	C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cd00037
992406001228	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
992406001229	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
992406001230	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
992406001231	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
992406001232	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
992406001233	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
992406001234	putative dimer interface [polypeptide binding]; other site
992406001235	putative anticodon binding site; other site
992406001236	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
992406001237	homodimer interface [polypeptide binding]; other site
992406001238	motif 1; other site
992406001239	motif 2; other site
992406001240	active site
992406001241	motif 3; other site
992406001242	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
992406001243	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
992406001244	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
992406001245	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406001246	WYL domain; Region: WYL; pfam13280
992406001247	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
992406001248	PLD-like domain; Region: PLDc_2; pfam13091
992406001249	putative active site [active]
992406001250	catalytic site [active]
992406001251	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
992406001252	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
992406001253	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
992406001254	VanZ like family; Region: VanZ; cl01971
992406001255	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
992406001256	lipoyl attachment site [posttranslational modification]; other site
992406001257	Dihydroneopterin aldolase; Region: FolB; pfam02152
992406001258	active site
992406001259	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
992406001260	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
992406001261	catalytic site [active]
992406001262	G-X2-G-X-G-K; other site
992406001263	hypothetical protein; Provisional; Region: PRK11820
992406001264	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
992406001265	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
992406001266	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
992406001267	enoyl-CoA hydratase; Provisional; Region: PRK08140
992406001268	substrate binding site [chemical binding]; other site
992406001269	oxyanion hole (OAH) forming residues; other site
992406001270	trimer interface [polypeptide binding]; other site
992406001271	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
992406001272	active site
992406001273	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
992406001274	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
992406001275	Walker A/P-loop; other site
992406001276	ATP binding site [chemical binding]; other site
992406001277	Q-loop/lid; other site
992406001278	ABC transporter signature motif; other site
992406001279	Walker B; other site
992406001280	D-loop; other site
992406001281	H-loop/switch region; other site
992406001282	ABC transporter; Region: ABC_tran_2; pfam12848
992406001283	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
992406001284	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
992406001285	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406001286	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
992406001287	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
992406001288	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
992406001289	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
992406001290	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
992406001291	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
992406001292	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
992406001293	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
992406001294	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
992406001295	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
992406001296	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
992406001297	DNA binding site [nucleotide binding]
992406001298	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
992406001299	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
992406001300	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
992406001301	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
992406001302	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
992406001303	RPB11 interaction site [polypeptide binding]; other site
992406001304	RPB12 interaction site [polypeptide binding]; other site
992406001305	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
992406001306	RPB3 interaction site [polypeptide binding]; other site
992406001307	RPB1 interaction site [polypeptide binding]; other site
992406001308	RPB11 interaction site [polypeptide binding]; other site
992406001309	RPB10 interaction site [polypeptide binding]; other site
992406001310	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
992406001311	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
992406001312	peripheral dimer interface [polypeptide binding]; other site
992406001313	core dimer interface [polypeptide binding]; other site
992406001314	L10 interface [polypeptide binding]; other site
992406001315	L11 interface [polypeptide binding]; other site
992406001316	putative EF-Tu interaction site [polypeptide binding]; other site
992406001317	putative EF-G interaction site [polypeptide binding]; other site
992406001318	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
992406001319	23S rRNA interface [nucleotide binding]; other site
992406001320	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
992406001321	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
992406001322	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
992406001323	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
992406001324	23S rRNA interface [nucleotide binding]; other site
992406001325	L7/L12 interface [polypeptide binding]; other site
992406001326	putative thiostrepton binding site; other site
992406001327	L25 interface [polypeptide binding]; other site
992406001328	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
992406001329	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
992406001330	putative homodimer interface [polypeptide binding]; other site
992406001331	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
992406001332	heterodimer interface [polypeptide binding]; other site
992406001333	homodimer interface [polypeptide binding]; other site
992406001334	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
992406001335	elongation factor Tu; Reviewed; Region: PRK12735
992406001336	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
992406001337	G1 box; other site
992406001338	GEF interaction site [polypeptide binding]; other site
992406001339	GTP/Mg2+ binding site [chemical binding]; other site
992406001340	Switch I region; other site
992406001341	G2 box; other site
992406001342	G3 box; other site
992406001343	Switch II region; other site
992406001344	G4 box; other site
992406001345	G5 box; other site
992406001346	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
992406001347	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
992406001348	Antibiotic Binding Site [chemical binding]; other site
992406001349	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
992406001350	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
992406001351	quinone interaction residues [chemical binding]; other site
992406001352	active site
992406001353	catalytic residues [active]
992406001354	FMN binding site [chemical binding]; other site
992406001355	substrate binding site [chemical binding]; other site
992406001356	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
992406001357	30S subunit binding site; other site
992406001358	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
992406001359	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
992406001360	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
992406001361	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
992406001362	active site
992406001363	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
992406001364	active site
992406001365	oligomerization interface [polypeptide binding]; other site
992406001366	metal binding site [ion binding]; metal-binding site
992406001367	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
992406001368	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
992406001369	ligand binding site [chemical binding]; other site
992406001370	flexible hinge region; other site
992406001371	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
992406001372	non-specific DNA interactions [nucleotide binding]; other site
992406001373	DNA binding site [nucleotide binding]
992406001374	sequence specific DNA binding site [nucleotide binding]; other site
992406001375	putative cAMP binding site [chemical binding]; other site
992406001376	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
992406001377	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
992406001378	Heavy-metal-associated domain; Region: HMA; pfam00403
992406001379	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
992406001380	Soluble P-type ATPase [General function prediction only]; Region: COG4087
992406001381	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
992406001382	putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485
992406001383	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
992406001384	Low-spin heme binding site [chemical binding]; other site
992406001385	Putative water exit pathway; other site
992406001386	Binuclear center (active site) [active]
992406001387	Putative proton exit pathway; other site
992406001388	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
992406001389	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
992406001390	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
992406001391	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
992406001392	FixH; Region: FixH; pfam05751
992406001393	Family description; Region: DsbD_2; pfam13386
992406001394	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
992406001395	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
992406001396	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
992406001397	active site
992406001398	catalytic site [active]
992406001399	substrate binding site [chemical binding]; other site
992406001400	Domain of unknown function DUF59; Region: DUF59; cl00941
992406001401	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
992406001402	23S rRNA interface [nucleotide binding]; other site
992406001403	L3 interface [polypeptide binding]; other site
992406001404	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
992406001405	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
992406001406	rRNA interaction site [nucleotide binding]; other site
992406001407	S8 interaction site; other site
992406001408	putative laminin-1 binding site; other site
992406001409	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
992406001410	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
992406001411	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406001412	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406001413	Phytase; Region: Phytase; cl17685
992406001414	transcription termination factor Rho; Provisional; Region: PRK12608
992406001415	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
992406001416	RNA binding site [nucleotide binding]; other site
992406001417	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
992406001418	multimer interface [polypeptide binding]; other site
992406001419	Walker A motif; other site
992406001420	ATP binding site [chemical binding]; other site
992406001421	Walker B motif; other site
992406001422	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
992406001423	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
992406001424	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
992406001425	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
992406001426	Walker A/P-loop; other site
992406001427	ATP binding site [chemical binding]; other site
992406001428	Q-loop/lid; other site
992406001429	ABC transporter signature motif; other site
992406001430	Walker B; other site
992406001431	D-loop; other site
992406001432	H-loop/switch region; other site
992406001433	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
992406001434	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
992406001435	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
992406001436	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
992406001437	active site
992406001438	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
992406001439	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
992406001440	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
992406001441	Malic enzyme, N-terminal domain; Region: malic; pfam00390
992406001442	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
992406001443	putative NAD(P) binding site [chemical binding]; other site
992406001444	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
992406001445	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
992406001446	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
992406001447	Restriction endonuclease EcoRI; Region: EcoRI; pfam02963
992406001448	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406001449	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
992406001450	Predicted membrane protein [Function unknown]; Region: COG2246
992406001451	GtrA-like protein; Region: GtrA; pfam04138
992406001452	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
992406001453	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
992406001454	putative acyl-acceptor binding pocket; other site
992406001455	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
992406001456	L-fucose transporter; Provisional; Region: PRK10133; cl17665
992406001457	L-fucose transporter; Provisional; Region: PRK10133; cl17665
992406001458	Protein of unknown function (DUF3810); Region: DUF3810; pfam12725
992406001459	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
992406001460	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
992406001461	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
992406001462	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
992406001463	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
992406001464	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
992406001465	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
992406001466	dimerization interface [polypeptide binding]; other site
992406001467	active site
992406001468	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
992406001469	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
992406001470	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
992406001471	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
992406001472	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
992406001473	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
992406001474	active site
992406001475	Substrate binding site; other site
992406001476	Mg++ binding site; other site
992406001477	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
992406001478	putative trimer interface [polypeptide binding]; other site
992406001479	putative CoA binding site [chemical binding]; other site
992406001480	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
992406001481	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
992406001482	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
992406001483	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
992406001484	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
992406001485	active site
992406001486	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
992406001487	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
992406001488	active site
992406001489	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
992406001490	trimer interface [polypeptide binding]; other site
992406001491	active site
992406001492	substrate binding site [chemical binding]; other site
992406001493	CoA binding site [chemical binding]; other site
992406001494	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
992406001495	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
992406001496	active site
992406001497	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
992406001498	active site
992406001499	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
992406001500	potential frameshift: common BLAST hit: gi|313206925|ref|YP_004046102.1| acyltransferase 3
992406001501	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
992406001502	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
992406001503	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
992406001504	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
992406001505	active site
992406001506	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
992406001507	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
992406001508	UDP-galactopyranose mutase; Region: GLF; pfam03275
992406001509	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
992406001510	GTP cyclohydrolase I; Provisional; Region: PLN03044
992406001511	active site
992406001512	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
992406001513	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
992406001514	active site
992406001515	HIGH motif; other site
992406001516	nucleotide binding site [chemical binding]; other site
992406001517	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
992406001518	KMSKS motif; other site
992406001519	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
992406001520	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
992406001521	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
992406001522	NAD(P) binding site [chemical binding]; other site
992406001523	active site
992406001524	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
992406001525	Uncharacterized conserved protein [Function unknown]; Region: COG2966
992406001526	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
992406001527	Preprotein translocase subunit; Region: YajC; pfam02699
992406001528	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
992406001529	transcription antitermination factor NusB; Region: nusB; TIGR01951
992406001530	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
992406001531	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
992406001532	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
992406001533	S-adenosylmethionine synthetase; Validated; Region: PRK05250
992406001534	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
992406001535	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
992406001536	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
992406001537	Transcriptional regulator [Transcription]; Region: LysR; COG0583
992406001538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
992406001539	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
992406001540	dimerization interface [polypeptide binding]; other site
992406001541	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
992406001542	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
992406001543	tetramer interface [polypeptide binding]; other site
992406001544	heme binding pocket [chemical binding]; other site
992406001545	NADPH binding site [chemical binding]; other site
992406001546	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
992406001547	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
992406001548	active site
992406001549	catalytic tetrad [active]
992406001550	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
992406001551	enoyl-CoA hydratase; Provisional; Region: PRK07658
992406001552	substrate binding site [chemical binding]; other site
992406001553	oxyanion hole (OAH) forming residues; other site
992406001554	trimer interface [polypeptide binding]; other site
992406001555	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
992406001556	catalytic motif [active]
992406001557	Zn binding site [ion binding]; other site
992406001558	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
992406001559	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
992406001560	active site
992406001561	DNA binding site [nucleotide binding]
992406001562	Int/Topo IB signature motif; other site
992406001563	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
992406001564	nudix motif; other site
992406001565	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
992406001566	Ferritin-like domain; Region: Ferritin; pfam00210
992406001567	ferroxidase diiron center [ion binding]; other site
992406001568	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
992406001569	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406001570	Walker A motif; other site
992406001571	ATP binding site [chemical binding]; other site
992406001572	Walker B motif; other site
992406001573	arginine finger; other site
992406001574	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
992406001575	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
992406001576	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
992406001577	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
992406001578	CoA-binding site [chemical binding]; other site
992406001579	ATP-binding [chemical binding]; other site
992406001580	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
992406001581	Cation efflux family; Region: Cation_efflux; pfam01545
992406001582	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
992406001583	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
992406001584	GIY-YIG motif/motif A; other site
992406001585	active site
992406001586	catalytic site [active]
992406001587	putative DNA binding site [nucleotide binding]; other site
992406001588	metal binding site [ion binding]; metal-binding site
992406001589	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
992406001590	VanZ like family; Region: VanZ; pfam04892
992406001591	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
992406001592	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
992406001593	putative active site [active]
992406001594	catalytic triad [active]
992406001595	putative dimer interface [polypeptide binding]; other site
992406001596	Phosphotransferase enzyme family; Region: APH; pfam01636
992406001597	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
992406001598	AAA domain; Region: AAA_30; pfam13604
992406001599	AAA domain; Region: AAA_22; pfam13401
992406001600	Family description; Region: UvrD_C_2; pfam13538
992406001601	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
992406001602	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
992406001603	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
992406001604	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
992406001605	trimer interface [polypeptide binding]; other site
992406001606	putative metal binding site [ion binding]; other site
992406001607	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
992406001608	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
992406001609	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
992406001610	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
992406001611	NAD(P) binding site [chemical binding]; other site
992406001612	active site
992406001613	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406001614	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406001615	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406001616	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406001617	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
992406001618	elongation factor G; Reviewed; Region: PRK12739
992406001619	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
992406001620	G1 box; other site
992406001621	putative GEF interaction site [polypeptide binding]; other site
992406001622	GTP/Mg2+ binding site [chemical binding]; other site
992406001623	Switch I region; other site
992406001624	G2 box; other site
992406001625	G3 box; other site
992406001626	Switch II region; other site
992406001627	G4 box; other site
992406001628	G5 box; other site
992406001629	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
992406001630	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
992406001631	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
992406001632	30S ribosomal protein S7; Validated; Region: PRK05302
992406001633	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
992406001634	S17 interaction site [polypeptide binding]; other site
992406001635	S8 interaction site; other site
992406001636	16S rRNA interaction site [nucleotide binding]; other site
992406001637	streptomycin interaction site [chemical binding]; other site
992406001638	23S rRNA interaction site [nucleotide binding]; other site
992406001639	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
992406001640	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
992406001641	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
992406001642	dimerization interface [polypeptide binding]; other site
992406001643	DPS ferroxidase diiron center [ion binding]; other site
992406001644	ion pore; other site
992406001645	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
992406001646	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
992406001647	active site
992406001648	RmuC family; Region: RmuC; pfam02646
992406001649	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
992406001650	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
992406001651	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
992406001652	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
992406001653	Coenzyme A binding pocket [chemical binding]; other site
992406001654	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
992406001655	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
992406001656	dimer interface [polypeptide binding]; other site
992406001657	active site
992406001658	heme binding site [chemical binding]; other site
992406001659	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
992406001660	Flagellin N-methylase; Region: FliB; pfam03692
992406001661	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
992406001662	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
992406001663	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
992406001664	catalytic residue [active]
992406001665	glycyl-tRNA synthetase; Provisional; Region: PRK04173
992406001666	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
992406001667	motif 1; other site
992406001668	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
992406001669	active site
992406001670	motif 2; other site
992406001671	motif 3; other site
992406001672	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
992406001673	anticodon binding site; other site
992406001674	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
992406001675	active site
992406001676	catalytic residues [active]
992406001677	metal binding site [ion binding]; metal-binding site
992406001678	peptidase T; Region: peptidase-T; TIGR01882
992406001679	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
992406001680	metal binding site [ion binding]; metal-binding site
992406001681	dimer interface [polypeptide binding]; other site
992406001682	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
992406001683	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406001684	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
992406001685	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
992406001686	ligand binding site [chemical binding]; other site
992406001687	flexible hinge region; other site
992406001688	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
992406001689	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
992406001690	tRNA; other site
992406001691	putative tRNA binding site [nucleotide binding]; other site
992406001692	putative NADP binding site [chemical binding]; other site
992406001693	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
992406001694	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
992406001695	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
992406001696	domain interfaces; other site
992406001697	active site
992406001698	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
992406001699	active site
992406001700	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
992406001701	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
992406001702	substrate binding site [chemical binding]; other site
992406001703	active site
992406001704	bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191
992406001705	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
992406001706	Coenzyme A binding pocket [chemical binding]; other site
992406001707	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
992406001708	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
992406001709	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
992406001710	N-terminal plug; other site
992406001711	ligand-binding site [chemical binding]; other site
992406001712	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
992406001713	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
992406001714	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
992406001715	Bacterial SH3 domain; Region: SH3_3; cl17532
992406001716	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
992406001717	NlpC/P60 family; Region: NLPC_P60; pfam00877
992406001718	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
992406001719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406001720	S-adenosylmethionine binding site [chemical binding]; other site
992406001721	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
992406001722	ligand binding site [chemical binding]; other site
992406001723	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
992406001724	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
992406001725	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
992406001726	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
992406001727	rod shape-determining protein MreC; Provisional; Region: PRK13922
992406001728	rod shape-determining protein MreC; Region: MreC; pfam04085
992406001729	rod shape-determining protein MreB; Provisional; Region: PRK13927
992406001730	MreB and similar proteins; Region: MreB_like; cd10225
992406001731	nucleotide binding site [chemical binding]; other site
992406001732	Mg binding site [ion binding]; other site
992406001733	putative protofilament interaction site [polypeptide binding]; other site
992406001734	RodZ interaction site [polypeptide binding]; other site
992406001735	GTP-binding protein Der; Reviewed; Region: PRK00093
992406001736	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
992406001737	G1 box; other site
992406001738	GTP/Mg2+ binding site [chemical binding]; other site
992406001739	Switch I region; other site
992406001740	G2 box; other site
992406001741	Switch II region; other site
992406001742	G3 box; other site
992406001743	G4 box; other site
992406001744	G5 box; other site
992406001745	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
992406001746	G1 box; other site
992406001747	GTP/Mg2+ binding site [chemical binding]; other site
992406001748	Switch I region; other site
992406001749	G2 box; other site
992406001750	G3 box; other site
992406001751	Switch II region; other site
992406001752	G4 box; other site
992406001753	G5 box; other site
992406001754	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
992406001755	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
992406001756	nucleotide binding site [chemical binding]; other site
992406001757	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
992406001758	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406001759	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
992406001760	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
992406001761	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
992406001762	nucleotide binding region [chemical binding]; other site
992406001763	ATP-binding site [chemical binding]; other site
992406001764	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
992406001765	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
992406001766	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
992406001767	NAD(P) binding site [chemical binding]; other site
992406001768	active site
992406001769	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
992406001770	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
992406001771	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
992406001772	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
992406001773	Substrate binding site; other site
992406001774	metal-binding site
992406001775	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
992406001776	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
992406001777	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
992406001778	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
992406001779	active site
992406001780	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
992406001781	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
992406001782	putative ATP binding site [chemical binding]; other site
992406001783	putative substrate interface [chemical binding]; other site
992406001784	Ribonuclease P; Region: Ribonuclease_P; pfam00825
992406001785	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406001786	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
992406001787	Walker A motif; other site
992406001788	ATP binding site [chemical binding]; other site
992406001789	Walker B motif; other site
992406001790	arginine finger; other site
992406001791	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
992406001792	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329
992406001793	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
992406001794	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
992406001795	FeS/SAM binding site; other site
992406001796	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
992406001797	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
992406001798	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
992406001799	active site
992406001800	thiamine-monophosphate kinase; Region: thiL; TIGR01379
992406001801	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
992406001802	ATP binding site [chemical binding]; other site
992406001803	dimerization interface [polypeptide binding]; other site
992406001804	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406001805	biotin synthase; Region: bioB; TIGR00433
992406001806	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
992406001807	FeS/SAM binding site; other site
992406001808	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
992406001809	Protein of unknown function (DUF502); Region: DUF502; cl01107
992406001810	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406001811	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
992406001812	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
992406001813	Walker A/P-loop; other site
992406001814	ATP binding site [chemical binding]; other site
992406001815	Q-loop/lid; other site
992406001816	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
992406001817	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
992406001818	Q-loop/lid; other site
992406001819	ABC transporter signature motif; other site
992406001820	Walker B; other site
992406001821	D-loop; other site
992406001822	H-loop/switch region; other site
992406001823	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
992406001824	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
992406001825	active site
992406001826	catalytic site [active]
992406001827	substrate binding site [chemical binding]; other site
992406001828	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
992406001829	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
992406001830	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
992406001831	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
992406001832	active site residue [active]
992406001833	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
992406001834	active site residue [active]
992406001835	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
992406001836	active site residue [active]
992406001837	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
992406001838	active site residue [active]
992406001839	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
992406001840	catalytic residues [active]
992406001841	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
992406001842	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
992406001843	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
992406001844	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
992406001845	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
992406001846	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
992406001847	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
992406001848	ligand binding site [chemical binding]; other site
992406001849	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
992406001850	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
992406001851	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
992406001852	starch binding outer membrane protein SusD; Region: SusD; cd08977
992406001853	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
992406001854	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
992406001855	translation initiation factor IF-2; Region: IF-2; TIGR00487
992406001856	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
992406001857	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
992406001858	G1 box; other site
992406001859	putative GEF interaction site [polypeptide binding]; other site
992406001860	GTP/Mg2+ binding site [chemical binding]; other site
992406001861	Switch I region; other site
992406001862	G2 box; other site
992406001863	G3 box; other site
992406001864	Switch II region; other site
992406001865	G4 box; other site
992406001866	G5 box; other site
992406001867	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
992406001868	Translation-initiation factor 2; Region: IF-2; pfam11987
992406001869	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
992406001870	transcription termination factor NusA; Region: NusA; TIGR01953
992406001871	NusA N-terminal domain; Region: NusA_N; pfam08529
992406001872	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
992406001873	RNA binding site [nucleotide binding]; other site
992406001874	homodimer interface [polypeptide binding]; other site
992406001875	NusA-like KH domain; Region: KH_5; pfam13184
992406001876	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
992406001877	G-X-X-G motif; other site
992406001878	Sm and related proteins; Region: Sm_like; cl00259
992406001879	heptamer interface [polypeptide binding]; other site
992406001880	Sm1 motif; other site
992406001881	hexamer interface [polypeptide binding]; other site
992406001882	RNA binding site [nucleotide binding]; other site
992406001883	Sm2 motif; other site
992406001884	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
992406001885	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
992406001886	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
992406001887	Active site serine [active]
992406001888	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
992406001889	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
992406001890	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
992406001891	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
992406001892	G1 box; other site
992406001893	GTP/Mg2+ binding site [chemical binding]; other site
992406001894	Switch I region; other site
992406001895	G2 box; other site
992406001896	G3 box; other site
992406001897	Switch II region; other site
992406001898	G4 box; other site
992406001899	G5 box; other site
992406001900	Nucleoside recognition; Region: Gate; pfam07670
992406001901	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
992406001902	Nucleoside recognition; Region: Gate; pfam07670
992406001903	FeoA domain; Region: FeoA; pfam04023
992406001904	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
992406001905	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
992406001906	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
992406001907	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
992406001908	HflX GTPase family; Region: HflX; cd01878
992406001909	G1 box; other site
992406001910	GTP/Mg2+ binding site [chemical binding]; other site
992406001911	Switch I region; other site
992406001912	G2 box; other site
992406001913	G3 box; other site
992406001914	Switch II region; other site
992406001915	G4 box; other site
992406001916	G5 box; other site
992406001917	NUMOD4 motif; Region: NUMOD4; pfam07463
992406001918	HNH endonuclease; Region: HNH_3; pfam13392
992406001919	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
992406001920	Surface antigen; Region: Bac_surface_Ag; pfam01103
992406001921	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
992406001922	dimer interface [polypeptide binding]; other site
992406001923	FMN binding site [chemical binding]; other site
992406001924	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
992406001925	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406001926	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406001927	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
992406001928	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
992406001929	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406001930	Heavy-metal-associated domain; Region: HMA; pfam00403
992406001931	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
992406001932	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406001933	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
992406001934	A new structural DNA glycosylase; Region: AlkD_like; cd06561
992406001935	active site
992406001936	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
992406001937	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
992406001938	FAD binding pocket [chemical binding]; other site
992406001939	conserved FAD binding motif [chemical binding]; other site
992406001940	phosphate binding motif [ion binding]; other site
992406001941	beta-alpha-beta structure motif; other site
992406001942	NAD binding pocket [chemical binding]; other site
992406001943	A new structural DNA glycosylase; Region: AlkD_like; cl11434
992406001944	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
992406001945	Rhomboid family; Region: Rhomboid; cl11446
992406001946	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
992406001947	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
992406001948	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
992406001949	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
992406001950	NlpC/P60 family; Region: NLPC_P60; pfam00877
992406001951	Tic20-like protein; Region: Tic20; pfam09685
992406001952	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
992406001953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
992406001954	active site
992406001955	phosphorylation site [posttranslational modification]
992406001956	intermolecular recognition site; other site
992406001957	dimerization interface [polypeptide binding]; other site
992406001958	LytTr DNA-binding domain; Region: LytTR; smart00850
992406001959	Histidine kinase; Region: His_kinase; pfam06580
992406001960	hypothetical protein; Reviewed; Region: PRK12497
992406001961	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
992406001962	dimer interface [polypeptide binding]; other site
992406001963	catalytic triad [active]
992406001964	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
992406001965	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
992406001966	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
992406001967	active site
992406001968	HIGH motif; other site
992406001969	dimer interface [polypeptide binding]; other site
992406001970	KMSKS motif; other site
992406001971	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
992406001972	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
992406001973	motif II; other site
992406001974	RNA polymerase sigma factor; Provisional; Region: PRK12513
992406001975	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
992406001976	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
992406001977	DNA binding residues [nucleotide binding]
992406001978	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406001979	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
992406001980	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
992406001981	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406001982	Walker A motif; other site
992406001983	ATP binding site [chemical binding]; other site
992406001984	Walker B motif; other site
992406001985	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
992406001986	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
992406001987	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
992406001988	Substrate binding site; other site
992406001989	SprT homologues; Region: SprT; cl01182
992406001990	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
992406001991	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
992406001992	5S rRNA interface [nucleotide binding]; other site
992406001993	CTC domain interface [polypeptide binding]; other site
992406001994	L16 interface [polypeptide binding]; other site
992406001995	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
992406001996	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
992406001997	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
992406001998	active site
992406001999	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
992406002000	catalytic triad [active]
992406002001	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
992406002002	DinB superfamily; Region: DinB_2; pfam12867
992406002003	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
992406002004	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
992406002005	ligand binding site [chemical binding]; other site
992406002006	excinuclease ABC subunit B; Provisional; Region: PRK05298
992406002007	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
992406002008	ATP binding site [chemical binding]; other site
992406002009	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
992406002010	nucleotide binding region [chemical binding]; other site
992406002011	ATP-binding site [chemical binding]; other site
992406002012	Ultra-violet resistance protein B; Region: UvrB; pfam12344
992406002013	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
992406002014	ATP-grasp domain; Region: ATP-grasp_4; cl17255
992406002015	C-N hydrolase family amidase; Provisional; Region: PRK10438
992406002016	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
992406002017	putative active site [active]
992406002018	catalytic triad [active]
992406002019	dimer interface [polypeptide binding]; other site
992406002020	multimer interface [polypeptide binding]; other site
992406002021	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
992406002022	RIP metalloprotease RseP; Region: TIGR00054
992406002023	active site
992406002024	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
992406002025	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
992406002026	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
992406002027	putative substrate binding region [chemical binding]; other site
992406002028	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
992406002029	active site
992406002030	DNA binding site [nucleotide binding]
992406002031	Int/Topo IB signature motif; other site
992406002032	DEAD-like helicases superfamily; Region: DEXDc; smart00487
992406002033	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
992406002034	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
992406002035	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
992406002036	non-specific DNA binding site [nucleotide binding]; other site
992406002037	salt bridge; other site
992406002038	sequence-specific DNA binding site [nucleotide binding]; other site
992406002039	FtsH Extracellular; Region: FtsH_ext; pfam06480
992406002040	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
992406002041	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406002042	Walker A motif; other site
992406002043	ATP binding site [chemical binding]; other site
992406002044	Walker B motif; other site
992406002045	arginine finger; other site
992406002046	Peptidase family M41; Region: Peptidase_M41; pfam01434
992406002047	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
992406002048	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
992406002049	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
992406002050	Predicted permeases [General function prediction only]; Region: COG0795
992406002051	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
992406002052	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
992406002053	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
992406002054	Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
992406002055	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
992406002056	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
992406002057	Ligand binding site; other site
992406002058	Putative Catalytic site; other site
992406002059	DXD motif; other site
992406002060	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
992406002061	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
992406002062	MutS domain I; Region: MutS_I; pfam01624
992406002063	MutS domain II; Region: MutS_II; pfam05188
992406002064	MutS domain III; Region: MutS_III; pfam05192
992406002065	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
992406002066	Walker A/P-loop; other site
992406002067	ATP binding site [chemical binding]; other site
992406002068	Q-loop/lid; other site
992406002069	ABC transporter signature motif; other site
992406002070	Walker B; other site
992406002071	D-loop; other site
992406002072	H-loop/switch region; other site
992406002073	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
992406002074	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
992406002075	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
992406002076	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
992406002077	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
992406002078	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
992406002079	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
992406002080	Mg++ binding site [ion binding]; other site
992406002081	putative catalytic motif [active]
992406002082	substrate binding site [chemical binding]; other site
992406002083	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
992406002084	putative active site [active]
992406002085	putative metal binding site [ion binding]; other site
992406002086	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
992406002087	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
992406002088	active site
992406002089	interdomain interaction site; other site
992406002090	putative metal-binding site [ion binding]; other site
992406002091	nucleotide binding site [chemical binding]; other site
992406002092	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
992406002093	domain I; other site
992406002094	DNA binding groove [nucleotide binding]
992406002095	phosphate binding site [ion binding]; other site
992406002096	domain II; other site
992406002097	domain III; other site
992406002098	nucleotide binding site [chemical binding]; other site
992406002099	catalytic site [active]
992406002100	domain IV; other site
992406002101	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
992406002102	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
992406002103	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
992406002104	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
992406002105	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
992406002106	ribosomal protein L33; Region: rpl33; CHL00104
992406002107	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
992406002108	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
992406002109	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
992406002110	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
992406002111	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
992406002112	active site
992406002113	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
992406002114	Acyltransferase family; Region: Acyl_transf_3; pfam01757
992406002115	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
992406002116	homopentamer interface [polypeptide binding]; other site
992406002117	active site
992406002118	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
992406002119	active site
992406002120	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
992406002121	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
992406002122	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
992406002123	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
992406002124	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
992406002125	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
992406002126	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
992406002127	molybdopterin cofactor binding site; other site
992406002128	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
992406002129	4Fe-4S binding domain; Region: Fer4; cl02805
992406002130	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
992406002131	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
992406002132	Cytochrome c; Region: Cytochrom_C; pfam00034
992406002133	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
992406002134	heme-binding residues [chemical binding]; other site
992406002135	Sporulation related domain; Region: SPOR; cl10051
992406002136	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406002137	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
992406002138	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
992406002139	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
992406002140	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
992406002141	DNA binding residues [nucleotide binding]
992406002142	dimerization interface [polypeptide binding]; other site
992406002143	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
992406002144	ATP binding site [chemical binding]; other site
992406002145	substrate interface [chemical binding]; other site
992406002146	Transglycosylase; Region: Transgly; pfam00912
992406002147	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
992406002148	GldH lipoprotein; Region: GldH_lipo; pfam14109
992406002149	PSP1 C-terminal conserved region; Region: PSP1; cl00770
992406002150	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
992406002151	Dehydroquinase class II; Region: DHquinase_II; pfam01220
992406002152	active site
992406002153	trimer interface [polypeptide binding]; other site
992406002154	dimer interface [polypeptide binding]; other site
992406002155	Haem-binding domain; Region: Haem_bd; pfam14376
992406002156	Protein of unknown function, DUF393; Region: DUF393; pfam04134
992406002157	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406002158	Mechanosensitive ion channel; Region: MS_channel; pfam00924
992406002159	C-terminal peptidase (prc); Region: prc; TIGR00225
992406002160	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
992406002161	protein binding site [polypeptide binding]; other site
992406002162	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
992406002163	Catalytic dyad [active]
992406002164	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
992406002165	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
992406002166	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
992406002167	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
992406002168	putative active site [active]
992406002169	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
992406002170	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
992406002171	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
992406002172	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
992406002173	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
992406002174	Clp amino terminal domain; Region: Clp_N; pfam02861
992406002175	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406002176	Walker A motif; other site
992406002177	ATP binding site [chemical binding]; other site
992406002178	Walker B motif; other site
992406002179	arginine finger; other site
992406002180	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406002181	Walker A motif; other site
992406002182	ATP binding site [chemical binding]; other site
992406002183	Walker B motif; other site
992406002184	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
992406002185	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
992406002186	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
992406002187	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
992406002188	ribonuclease R; Region: RNase_R; TIGR02063
992406002189	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
992406002190	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
992406002191	RNB domain; Region: RNB; pfam00773
992406002192	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
992406002193	RNA binding site [nucleotide binding]; other site
992406002194	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
992406002195	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
992406002196	DNA binding residues [nucleotide binding]
992406002197	dimerization interface [polypeptide binding]; other site
992406002198	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
992406002199	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
992406002200	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
992406002201	NAD(P) binding site [chemical binding]; other site
992406002202	homotetramer interface [polypeptide binding]; other site
992406002203	homodimer interface [polypeptide binding]; other site
992406002204	active site
992406002205	Predicted methyltransferases [General function prediction only]; Region: COG0313
992406002206	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
992406002207	putative SAM binding site [chemical binding]; other site
992406002208	putative homodimer interface [polypeptide binding]; other site
992406002209	thymidine kinase; Provisional; Region: PRK04296
992406002210	putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930
992406002211	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
992406002212	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
992406002213	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
992406002214	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
992406002215	active site
992406002216	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
992406002217	dimer interface [polypeptide binding]; other site
992406002218	substrate binding site [chemical binding]; other site
992406002219	catalytic residues [active]
992406002220	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
992406002221	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
992406002222	Walker A/P-loop; other site
992406002223	ATP binding site [chemical binding]; other site
992406002224	Q-loop/lid; other site
992406002225	ABC transporter signature motif; other site
992406002226	Walker B; other site
992406002227	D-loop; other site
992406002228	H-loop/switch region; other site
992406002229	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
992406002230	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
992406002231	Outer membrane efflux protein; Region: OEP; pfam02321
992406002232	Outer membrane efflux protein; Region: OEP; pfam02321
992406002233	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
992406002234	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
992406002235	FAD binding domain; Region: FAD_binding_4; pfam01565
992406002236	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
992406002237	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
992406002238	Uncharacterized conserved protein [Function unknown]; Region: COG3743
992406002239	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
992406002240	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
992406002241	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
992406002242	putative catalytic residue [active]
992406002243	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
992406002244	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
992406002245	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
992406002246	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
992406002247	hinge; other site
992406002248	active site
992406002249	Domain of unknown function (DUF4290); Region: DUF4290; pfam14123
992406002250	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
992406002251	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
992406002252	active site
992406002253	phosphorylation site [posttranslational modification]
992406002254	intermolecular recognition site; other site
992406002255	dimerization interface [polypeptide binding]; other site
992406002256	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
992406002257	DNA binding site [nucleotide binding]
992406002258	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
992406002259	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
992406002260	dimer interface [polypeptide binding]; other site
992406002261	phosphorylation site [posttranslational modification]
992406002262	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
992406002263	ATP binding site [chemical binding]; other site
992406002264	Mg2+ binding site [ion binding]; other site
992406002265	G-X-G motif; other site
992406002266	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
992406002267	Zn binding site [ion binding]; other site
992406002268	Type III pantothenate kinase; Region: Pan_kinase; cl17198
992406002269	FeS assembly protein SufD; Region: sufD; TIGR01981
992406002270	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
992406002271	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
992406002272	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
992406002273	Walker A/P-loop; other site
992406002274	ATP binding site [chemical binding]; other site
992406002275	Q-loop/lid; other site
992406002276	ABC transporter signature motif; other site
992406002277	Walker B; other site
992406002278	D-loop; other site
992406002279	H-loop/switch region; other site
992406002280	Domain of unknown function (DUF336); Region: DUF336; pfam03928
992406002281	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
992406002282	active site
992406002283	homotetramer interface [polypeptide binding]; other site
992406002284	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
992406002285	NlpE N-terminal domain; Region: NlpE; pfam04170
992406002286	V-type ATP synthase subunit I; Validated; Region: PRK05771
992406002287	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
992406002288	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
992406002289	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
992406002290	putative ABC transporter; Region: ycf24; CHL00085
992406002291	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
992406002292	four helix bundle protein; Region: TIGR02436
992406002293	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
992406002294	GTP-binding protein LepA; Provisional; Region: PRK05433
992406002295	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
992406002296	G1 box; other site
992406002297	putative GEF interaction site [polypeptide binding]; other site
992406002298	GTP/Mg2+ binding site [chemical binding]; other site
992406002299	Switch I region; other site
992406002300	G2 box; other site
992406002301	G3 box; other site
992406002302	Switch II region; other site
992406002303	G4 box; other site
992406002304	G5 box; other site
992406002305	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
992406002306	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
992406002307	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
992406002308	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
992406002309	putative active site [active]
992406002310	lipoprotein signal peptidase; Provisional; Region: PRK14788
992406002311	lipoprotein signal peptidase; Provisional; Region: PRK14787
992406002312	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
992406002313	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
992406002314	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
992406002315	active site
992406002316	HIGH motif; other site
992406002317	nucleotide binding site [chemical binding]; other site
992406002318	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
992406002319	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
992406002320	active site
992406002321	KMSKS motif; other site
992406002322	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
992406002323	tRNA binding surface [nucleotide binding]; other site
992406002324	anticodon binding site; other site
992406002325	aspartate aminotransferase; Provisional; Region: PRK07568
992406002326	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
992406002327	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406002328	homodimer interface [polypeptide binding]; other site
992406002329	catalytic residue [active]
992406002330	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
992406002331	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406002332	Fic family protein [Function unknown]; Region: COG3177
992406002333	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
992406002334	Fic/DOC family; Region: Fic; pfam02661
992406002335	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406002336	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
992406002337	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
992406002338	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
992406002339	substrate-cofactor binding pocket; other site
992406002340	para-aminobenzoate synthase component I; Validated; Region: PRK07093
992406002341	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
992406002342	Domain of unknown function DUF20; Region: UPF0118; pfam01594
992406002343	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
992406002344	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
992406002345	binding surface
992406002346	TPR motif; other site
992406002347	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
992406002348	TPR motif; other site
992406002349	binding surface
992406002350	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
992406002351	binding surface
992406002352	TPR motif; other site
992406002353	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
992406002354	binding surface
992406002355	TPR motif; other site
992406002356	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
992406002357	binding surface
992406002358	TPR motif; other site
992406002359	TPR repeat; Region: TPR_11; pfam13414
992406002360	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
992406002361	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
992406002362	active site
992406002363	substrate binding site [chemical binding]; other site
992406002364	metal binding site [ion binding]; metal-binding site
992406002365	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
992406002366	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
992406002367	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
992406002368	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
992406002369	E3 interaction surface; other site
992406002370	lipoyl attachment site [posttranslational modification]; other site
992406002371	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
992406002372	lipoyl-biotinyl attachment site [posttranslational modification]; other site
992406002373	HlyD family secretion protein; Region: HlyD_3; pfam13437
992406002374	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
992406002375	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
992406002376	active site
992406002377	substrate-binding site [chemical binding]; other site
992406002378	metal-binding site [ion binding]
992406002379	ATP binding site [chemical binding]; other site
992406002380	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
992406002381	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
992406002382	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
992406002383	active site
992406002384	nucleophile elbow; other site
992406002385	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
992406002386	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
992406002387	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
992406002388	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
992406002389	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
992406002390	Methyltransferase domain; Region: Methyltransf_23; pfam13489
992406002391	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406002392	S-adenosylmethionine binding site [chemical binding]; other site
992406002393	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
992406002394	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
992406002395	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
992406002396	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
992406002397	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
992406002398	active site
992406002399	purine riboside binding site [chemical binding]; other site
992406002400	Phosphoglycerate kinase; Region: PGK; pfam00162
992406002401	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
992406002402	substrate binding site [chemical binding]; other site
992406002403	hinge regions; other site
992406002404	ADP binding site [chemical binding]; other site
992406002405	catalytic site [active]
992406002406	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
992406002407	Peptidase S46; Region: Peptidase_S46; pfam10459
992406002408	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
992406002409	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
992406002410	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
992406002411	dimer interface [polypeptide binding]; other site
992406002412	tetramer interface [polypeptide binding]; other site
992406002413	PYR/PP interface [polypeptide binding]; other site
992406002414	TPP binding site [chemical binding]; other site
992406002415	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
992406002416	TPP-binding site; other site
992406002417	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
992406002418	E-class dimer interface [polypeptide binding]; other site
992406002419	P-class dimer interface [polypeptide binding]; other site
992406002420	active site
992406002421	Cu2+ binding site [ion binding]; other site
992406002422	Zn2+ binding site [ion binding]; other site
992406002423	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
992406002424	nucleoside/Zn binding site; other site
992406002425	dimer interface [polypeptide binding]; other site
992406002426	catalytic motif [active]
992406002427	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
992406002428	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
992406002429	non-specific DNA binding site [nucleotide binding]; other site
992406002430	salt bridge; other site
992406002431	sequence-specific DNA binding site [nucleotide binding]; other site
992406002432	methionine sulfoxide reductase B; Provisional; Region: PRK00222
992406002433	SelR domain; Region: SelR; pfam01641
992406002434	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
992406002435	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406002436	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
992406002437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
992406002438	ATP binding site [chemical binding]; other site
992406002439	Mg2+ binding site [ion binding]; other site
992406002440	G-X-G motif; other site
992406002441	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
992406002442	ATP binding site [chemical binding]; other site
992406002443	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
992406002444	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
992406002445	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
992406002446	putative catalytic site [active]
992406002447	putative metal binding site [ion binding]; other site
992406002448	putative phosphate binding site [ion binding]; other site
992406002449	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
992406002450	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
992406002451	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
992406002452	TRAM domain; Region: TRAM; pfam01938
992406002453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406002454	S-adenosylmethionine binding site [chemical binding]; other site
992406002455	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
992406002456	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
992406002457	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
992406002458	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
992406002459	Domain of unknown function (DUF389); Region: DUF389; pfam04087
992406002460	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
992406002461	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
992406002462	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
992406002463	catalytic residue [active]
992406002464	putative FPP diphosphate  binding site; other site
992406002465	putative FPP binding hydrophobic cleft; other site
992406002466	dimer interface [polypeptide binding]; other site
992406002467	putative IPP diphosphate binding site; other site
992406002468	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
992406002469	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
992406002470	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
992406002471	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
992406002472	Surface antigen; Region: Bac_surface_Ag; pfam01103
992406002473	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
992406002474	periplasmic chaperone; Provisional; Region: PRK10780
992406002475	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
992406002476	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
992406002477	active site
992406002478	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
992406002479	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
992406002480	NADP binding site [chemical binding]; other site
992406002481	active site
992406002482	putative substrate binding site [chemical binding]; other site
992406002483	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406002484	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
992406002485	methionine sulfoxide reductase A; Provisional; Region: PRK14054
992406002486	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
992406002487	Coenzyme A binding pocket [chemical binding]; other site
992406002488	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
992406002489	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
992406002490	G1 box; other site
992406002491	GTP/Mg2+ binding site [chemical binding]; other site
992406002492	Switch I region; other site
992406002493	G2 box; other site
992406002494	G3 box; other site
992406002495	Switch II region; other site
992406002496	G4 box; other site
992406002497	G5 box; other site
992406002498	cell division protein MraZ; Reviewed; Region: PRK00326
992406002499	MraZ protein; Region: MraZ; pfam02381
992406002500	MraZ protein; Region: MraZ; pfam02381
992406002501	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
992406002502	MraW methylase family; Region: Methyltransf_5; cl17771
992406002503	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
992406002504	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
992406002505	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
992406002506	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
992406002507	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
992406002508	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
992406002509	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
992406002510	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
992406002511	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
992406002512	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
992406002513	Mg++ binding site [ion binding]; other site
992406002514	putative catalytic motif [active]
992406002515	putative substrate binding site [chemical binding]; other site
992406002516	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
992406002517	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
992406002518	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
992406002519	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
992406002520	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
992406002521	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
992406002522	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
992406002523	active site
992406002524	homodimer interface [polypeptide binding]; other site
992406002525	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
992406002526	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
992406002527	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
992406002528	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
992406002529	cell division protein FtsA; Region: ftsA; TIGR01174
992406002530	Cell division protein FtsA; Region: FtsA; smart00842
992406002531	Cell division protein FtsA; Region: FtsA; pfam14450
992406002532	cell division protein FtsZ; Validated; Region: PRK09330
992406002533	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
992406002534	nucleotide binding site [chemical binding]; other site
992406002535	SulA interaction site; other site
992406002536	potential frameshift: common BLAST hit: gi|383485828|ref|YP_005394740.1| aldehyde dehydrogenase
992406002537	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
992406002538	NAD(P) binding site [chemical binding]; other site
992406002539	catalytic residues [active]
992406002540	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
992406002541	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
992406002542	human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c; cd05339
992406002543	putative NAD(P) binding site [chemical binding]; other site
992406002544	homodimer interface [polypeptide binding]; other site
992406002545	active site
992406002546	substrate binding site [chemical binding]; other site
992406002547	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
992406002548	Surface antigen; Region: Bac_surface_Ag; pfam01103
992406002549	Family of unknown function (DUF490); Region: DUF490; pfam04357
992406002550	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
992406002551	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
992406002552	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
992406002553	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
992406002554	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
992406002555	ABC transporter; Region: ABC_tran_2; pfam12848
992406002556	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
992406002557	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
992406002558	SmpB-tmRNA interface; other site
992406002559	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
992406002560	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
992406002561	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
992406002562	ligand binding site [chemical binding]; other site
992406002563	hypothetical protein; Provisional; Region: PRK12378
992406002564	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
992406002565	peptide chain release factor 1; Validated; Region: prfA; PRK00591
992406002566	PCRF domain; Region: PCRF; pfam03462
992406002567	RF-1 domain; Region: RF-1; pfam00472
992406002568	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
992406002569	diaminopimelate decarboxylase; Region: lysA; TIGR01048
992406002570	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
992406002571	active site
992406002572	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
992406002573	substrate binding site [chemical binding]; other site
992406002574	catalytic residues [active]
992406002575	dimer interface [polypeptide binding]; other site
992406002576	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
992406002577	Amidinotransferase; Region: Amidinotransf; pfam02274
992406002578	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
992406002579	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
992406002580	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
992406002581	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
992406002582	HlyD family secretion protein; Region: HlyD_3; pfam13437
992406002583	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
992406002584	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
992406002585	putative active site [active]
992406002586	putative metal binding site [ion binding]; other site
992406002587	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
992406002588	starch binding outer membrane protein SusD; Region: SusD; cd08977
992406002589	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
992406002590	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
992406002591	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406002592	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
992406002593	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406002594	Cna protein B-type domain; Region: Cna_B_2; pfam13715
992406002595	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
992406002596	DHH family; Region: DHH; pfam01368
992406002597	DHHA1 domain; Region: DHHA1; pfam02272
992406002598	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
992406002599	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
992406002600	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
992406002601	Walker A/P-loop; other site
992406002602	ATP binding site [chemical binding]; other site
992406002603	Q-loop/lid; other site
992406002604	ABC transporter signature motif; other site
992406002605	Walker B; other site
992406002606	D-loop; other site
992406002607	H-loop/switch region; other site
992406002608	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
992406002609	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406002610	S-adenosylmethionine binding site [chemical binding]; other site
992406002611	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
992406002612	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
992406002613	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
992406002614	dimer interface [polypeptide binding]; other site
992406002615	phosphorylation site [posttranslational modification]
992406002616	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
992406002617	ATP binding site [chemical binding]; other site
992406002618	Mg2+ binding site [ion binding]; other site
992406002619	G-X-G motif; other site
992406002620	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
992406002621	Lumazine binding domain; Region: Lum_binding; pfam00677
992406002622	Lumazine binding domain; Region: Lum_binding; pfam00677
992406002623	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
992406002624	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
992406002625	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
992406002626	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
992406002627	acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531
992406002628	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
992406002629	carboxyltransferase (CT) interaction site; other site
992406002630	biotinylation site [posttranslational modification]; other site
992406002631	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
992406002632	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
992406002633	ATP-grasp domain; Region: ATP-grasp_4; cl17255
992406002634	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
992406002635	ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885
992406002636	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
992406002637	inhibitor-cofactor binding pocket; inhibition site
992406002638	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406002639	catalytic residue [active]
992406002640	The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693
992406002641	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
992406002642	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
992406002643	Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672
992406002644	Cupin domain; Region: Cupin_2; cl17218
992406002645	SurA N-terminal domain; Region: SurA_N_3; cl07813
992406002646	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
992406002647	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
992406002648	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
992406002649	mce related protein; Region: MCE; pfam02470
992406002650	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
992406002651	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
992406002652	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
992406002653	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
992406002654	Cysteine-rich domain; Region: CCG; pfam02754
992406002655	Cysteine-rich domain; Region: CCG; pfam02754
992406002656	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
992406002657	acyl carrier protein; Provisional; Region: acpP; PRK00982
992406002658	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
992406002659	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
992406002660	dimer interface [polypeptide binding]; other site
992406002661	active site
992406002662	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
992406002663	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
992406002664	dimerization interface [polypeptide binding]; other site
992406002665	active site
992406002666	metal binding site [ion binding]; metal-binding site
992406002667	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054
992406002668	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
992406002669	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
992406002670	active site
992406002671	domain interfaces; other site
992406002672	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
992406002673	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
992406002674	NAD(P) binding site [chemical binding]; other site
992406002675	catalytic residues [active]
992406002676	Serum amyloid A protein; Region: SAA; cl02506
992406002677	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
992406002678	Family description; Region: VCBS; pfam13517
992406002679	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
992406002680	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
992406002681	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
992406002682	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
992406002683	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
992406002684	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
992406002685	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
992406002686	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
992406002687	Ligand Binding Site [chemical binding]; other site
992406002688	TilS substrate C-terminal domain; Region: TilS_C; smart00977
992406002689	seryl-tRNA synthetase; Provisional; Region: PRK05431
992406002690	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
992406002691	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
992406002692	dimer interface [polypeptide binding]; other site
992406002693	active site
992406002694	motif 1; other site
992406002695	motif 2; other site
992406002696	motif 3; other site
992406002697	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
992406002698	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
992406002699	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
992406002700	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
992406002701	Peptidase family U32; Region: Peptidase_U32; pfam01136
992406002702	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
992406002703	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
992406002704	protein binding site [polypeptide binding]; other site
992406002705	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
992406002706	protein binding site [polypeptide binding]; other site
992406002707	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
992406002708	active site
992406002709	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
992406002710	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
992406002711	active site
992406002712	HIGH motif; other site
992406002713	nucleotide binding site [chemical binding]; other site
992406002714	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
992406002715	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
992406002716	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
992406002717	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
992406002718	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
992406002719	active site
992406002720	KMSKS motif; other site
992406002721	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
992406002722	tRNA binding surface [nucleotide binding]; other site
992406002723	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
992406002724	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
992406002725	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
992406002726	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
992406002727	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
992406002728	PBP superfamily domain; Region: PBP_like_2; pfam12849
992406002729	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
992406002730	TPR motif; other site
992406002731	binding surface
992406002732	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
992406002733	binding surface
992406002734	TPR motif; other site
992406002735	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
992406002736	Protein of unknown function (DUF3276); Region: DUF3276; pfam11680
992406002737	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
992406002738	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
992406002739	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
992406002740	Walker A/P-loop; other site
992406002741	ATP binding site [chemical binding]; other site
992406002742	Q-loop/lid; other site
992406002743	ABC transporter signature motif; other site
992406002744	Walker B; other site
992406002745	D-loop; other site
992406002746	H-loop/switch region; other site
992406002747	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
992406002748	active site
992406002749	catalytic residues [active]
992406002750	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
992406002751	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406002752	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
992406002753	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
992406002754	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
992406002755	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
992406002756	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
992406002757	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
992406002758	flavoprotein, HI0933 family; Region: TIGR00275
992406002759	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
992406002760	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
992406002761	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
992406002762	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
992406002763	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
992406002764	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
992406002765	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
992406002766	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
992406002767	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
992406002768	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
992406002769	active site
992406002770	intersubunit interface [polypeptide binding]; other site
992406002771	zinc binding site [ion binding]; other site
992406002772	Na+ binding site [ion binding]; other site
992406002773	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
992406002774	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
992406002775	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
992406002776	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
992406002777	intersubunit interface [polypeptide binding]; other site
992406002778	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
992406002779	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
992406002780	ABC-ATPase subunit  interface; other site
992406002781	dimer interface [polypeptide binding]; other site
992406002782	putative PBP binding regions; other site
992406002783	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
992406002784	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
992406002785	Walker A/P-loop; other site
992406002786	ATP binding site [chemical binding]; other site
992406002787	Q-loop/lid; other site
992406002788	ABC transporter signature motif; other site
992406002789	Walker B; other site
992406002790	D-loop; other site
992406002791	H-loop/switch region; other site
992406002792	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
992406002793	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
992406002794	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
992406002795	N-terminal plug; other site
992406002796	ligand-binding site [chemical binding]; other site
992406002797	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
992406002798	alpha-gamma subunit interface [polypeptide binding]; other site
992406002799	beta-gamma subunit interface [polypeptide binding]; other site
992406002800	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
992406002801	gamma-beta subunit interface [polypeptide binding]; other site
992406002802	alpha-beta subunit interface [polypeptide binding]; other site
992406002803	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
992406002804	subunit interactions [polypeptide binding]; other site
992406002805	urease subunit alpha; Reviewed; Region: ureC; PRK13207
992406002806	active site
992406002807	flap region; other site
992406002808	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
992406002809	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
992406002810	dimer interface [polypeptide binding]; other site
992406002811	catalytic residues [active]
992406002812	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
992406002813	UreF; Region: UreF; pfam01730
992406002814	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
992406002815	G1 box; other site
992406002816	GTP/Mg2+ binding site [chemical binding]; other site
992406002817	G2 box; other site
992406002818	Switch I region; other site
992406002819	G3 box; other site
992406002820	Switch II region; other site
992406002821	G4 box; other site
992406002822	G5 box; other site
992406002823	UreD urease accessory protein; Region: UreD; pfam01774
992406002824	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
992406002825	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
992406002826	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
992406002827	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
992406002828	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
992406002829	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
992406002830	Glycoprotease family; Region: Peptidase_M22; pfam00814
992406002831	Maf-like protein; Region: Maf; pfam02545
992406002832	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
992406002833	active site
992406002834	dimer interface [polypeptide binding]; other site
992406002835	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
992406002836	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
992406002837	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
992406002838	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
992406002839	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
992406002840	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
992406002841	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
992406002842	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
992406002843	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
992406002844	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
992406002845	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
992406002846	putative translocon binding site; other site
992406002847	protein-rRNA interface [nucleotide binding]; other site
992406002848	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
992406002849	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
992406002850	G-X-X-G motif; other site
992406002851	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
992406002852	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
992406002853	23S rRNA interface [nucleotide binding]; other site
992406002854	5S rRNA interface [nucleotide binding]; other site
992406002855	putative antibiotic binding site [chemical binding]; other site
992406002856	L25 interface [polypeptide binding]; other site
992406002857	L27 interface [polypeptide binding]; other site
992406002858	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
992406002859	23S rRNA interface [nucleotide binding]; other site
992406002860	putative translocon interaction site; other site
992406002861	signal recognition particle (SRP54) interaction site; other site
992406002862	L23 interface [polypeptide binding]; other site
992406002863	trigger factor interaction site; other site
992406002864	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
992406002865	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
992406002866	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
992406002867	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
992406002868	RNA binding site [nucleotide binding]; other site
992406002869	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
992406002870	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
992406002871	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
992406002872	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
992406002873	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
992406002874	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
992406002875	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
992406002876	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
992406002877	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
992406002878	5S rRNA interface [nucleotide binding]; other site
992406002879	L27 interface [polypeptide binding]; other site
992406002880	23S rRNA interface [nucleotide binding]; other site
992406002881	L5 interface [polypeptide binding]; other site
992406002882	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
992406002883	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
992406002884	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
992406002885	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
992406002886	23S rRNA binding site [nucleotide binding]; other site
992406002887	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
992406002888	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
992406002889	SecY translocase; Region: SecY; pfam00344
992406002890	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
992406002891	rRNA binding site [nucleotide binding]; other site
992406002892	predicted 30S ribosome binding site; other site
992406002893	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
992406002894	30S ribosomal protein S13; Region: bact_S13; TIGR03631
992406002895	30S ribosomal protein S11; Validated; Region: PRK05309
992406002896	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
992406002897	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
992406002898	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
992406002899	RNA binding surface [nucleotide binding]; other site
992406002900	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
992406002901	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
992406002902	alphaNTD - beta interaction site [polypeptide binding]; other site
992406002903	alphaNTD homodimer interface [polypeptide binding]; other site
992406002904	alphaNTD - beta' interaction site [polypeptide binding]; other site
992406002905	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
992406002906	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
992406002907	Amidinotransferase; Region: Amidinotransf; cl12043
992406002908	potential frameshift: common BLAST hit: gi|383485670|ref|YP_005394582.1| alkyl hydroperoxide reductase/ thiol specific antioxidant/ mal
992406002909	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
992406002910	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
992406002911	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
992406002912	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
992406002913	dimer interface [polypeptide binding]; other site
992406002914	Citrate synthase; Region: Citrate_synt; pfam00285
992406002915	active site
992406002916	citrylCoA binding site [chemical binding]; other site
992406002917	NADH binding [chemical binding]; other site
992406002918	cationic pore residues; other site
992406002919	oxalacetate/citrate binding site [chemical binding]; other site
992406002920	coenzyme A binding site [chemical binding]; other site
992406002921	catalytic triad [active]
992406002922	enolase; Provisional; Region: eno; PRK00077
992406002923	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
992406002924	dimer interface [polypeptide binding]; other site
992406002925	metal binding site [ion binding]; metal-binding site
992406002926	substrate binding pocket [chemical binding]; other site
992406002927	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
992406002928	homotrimer interaction site [polypeptide binding]; other site
992406002929	putative active site [active]
992406002930	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
992406002931	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
992406002932	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
992406002933	active site
992406002934	metal binding site [ion binding]; metal-binding site
992406002935	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
992406002936	Domain of unknown function (DUF3817); Region: DUF3817; cl14844
992406002937	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
992406002938	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
992406002939	active site
992406002940	(T/H)XGH motif; other site
992406002941	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
992406002942	DHH family; Region: DHH; pfam01368
992406002943	DHHA1 domain; Region: DHHA1; pfam02272
992406002944	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
992406002945	short chain dehydrogenase; Provisional; Region: PRK07677
992406002946	NAD(P) binding site [chemical binding]; other site
992406002947	substrate binding site [chemical binding]; other site
992406002948	homotetramer interface [polypeptide binding]; other site
992406002949	active site
992406002950	homodimer interface [polypeptide binding]; other site
992406002951	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
992406002952	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
992406002953	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
992406002954	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
992406002955	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
992406002956	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
992406002957	dihydroorotase; Reviewed; Region: PRK09236
992406002958	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
992406002959	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
992406002960	active site
992406002961	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
992406002962	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
992406002963	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
992406002964	putative ADP-binding pocket [chemical binding]; other site
992406002965	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
992406002966	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
992406002967	active site
992406002968	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
992406002969	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
992406002970	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
992406002971	putative ADP-binding pocket [chemical binding]; other site
992406002972	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
992406002973	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
992406002974	trimer interface [polypeptide binding]; other site
992406002975	active site
992406002976	substrate binding site [chemical binding]; other site
992406002977	CoA binding site [chemical binding]; other site
992406002978	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
992406002979	active site clefts [active]
992406002980	zinc binding site [ion binding]; other site
992406002981	dimer interface [polypeptide binding]; other site
992406002982	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
992406002983	Sulfate transporter family; Region: Sulfate_transp; pfam00916
992406002984	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
992406002985	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406002986	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
992406002987	active site
992406002988	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
992406002989	putative active site [active]
992406002990	catalytic residue [active]
992406002991	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
992406002992	Clp amino terminal domain; Region: Clp_N; pfam02861
992406002993	Clp amino terminal domain; Region: Clp_N; pfam02861
992406002994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406002995	Walker A motif; other site
992406002996	ATP binding site [chemical binding]; other site
992406002997	Walker B motif; other site
992406002998	arginine finger; other site
992406002999	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406003000	Walker A motif; other site
992406003001	ATP binding site [chemical binding]; other site
992406003002	Walker B motif; other site
992406003003	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
992406003004	GH3 auxin-responsive promoter; Region: GH3; pfam03321
992406003005	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
992406003006	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
992406003007	HIGH motif; other site
992406003008	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
992406003009	active site
992406003010	KMSKS motif; other site
992406003011	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
992406003012	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
992406003013	elongation factor Ts; Provisional; Region: tsf; PRK09377
992406003014	UBA/TS-N domain; Region: UBA; pfam00627
992406003015	Elongation factor TS; Region: EF_TS; pfam00889
992406003016	Elongation factor TS; Region: EF_TS; pfam00889
992406003017	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
992406003018	endonuclease III; Region: ENDO3c; smart00478
992406003019	minor groove reading motif; other site
992406003020	helix-hairpin-helix signature motif; other site
992406003021	substrate binding pocket [chemical binding]; other site
992406003022	active site
992406003023	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
992406003024	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
992406003025	catalytic triad [active]
992406003026	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
992406003027	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
992406003028	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
992406003029	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
992406003030	active site
992406003031	cell surface protein SprA; Region: surface_SprA; TIGR04189
992406003032	Motility related/secretion protein; Region: SprA_N; pfam14349
992406003033	Motility related/secretion protein; Region: SprA_N; pfam14349
992406003034	Motility related/secretion protein; Region: SprA_N; pfam14349
992406003035	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
992406003036	RuvA N terminal domain; Region: RuvA_N; pfam01330
992406003037	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
992406003038	starch binding outer membrane protein SusD; Region: SusD; cd08977
992406003039	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
992406003040	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
992406003041	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
992406003042	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
992406003043	putative DNA binding site [nucleotide binding]; other site
992406003044	putative Zn2+ binding site [ion binding]; other site
992406003045	AsnC family; Region: AsnC_trans_reg; pfam01037
992406003046	Cna protein B-type domain; Region: Cna_B_2; pfam13715
992406003047	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
992406003048	active site
992406003049	putative DNA-binding cleft [nucleotide binding]; other site
992406003050	dimer interface [polypeptide binding]; other site
992406003051	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
992406003052	heme-binding site [chemical binding]; other site
992406003053	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
992406003054	DNA protecting protein DprA; Region: dprA; TIGR00732
992406003055	glutamate dehydrogenase; Provisional; Region: PRK09414
992406003056	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
992406003057	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
992406003058	NAD(P) binding site [chemical binding]; other site
992406003059	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
992406003060	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
992406003061	Zn2+ binding site [ion binding]; other site
992406003062	Mg2+ binding site [ion binding]; other site
992406003063	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
992406003064	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
992406003065	active site
992406003066	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
992406003067	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
992406003068	dimer interface [polypeptide binding]; other site
992406003069	putative radical transfer pathway; other site
992406003070	diiron center [ion binding]; other site
992406003071	tyrosyl radical; other site
992406003072	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
992406003073	Class I ribonucleotide reductase; Region: RNR_I; cd01679
992406003074	active site
992406003075	dimer interface [polypeptide binding]; other site
992406003076	catalytic residues [active]
992406003077	effector binding site; other site
992406003078	R2 peptide binding site; other site
992406003079	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
992406003080	Beta-lactamase; Region: Beta-lactamase; pfam00144
992406003081	Protein of unknown function DUF72; Region: DUF72; pfam01904
992406003082	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
992406003083	active site
992406003084	catalytic residues [active]
992406003085	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406003086	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
992406003087	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
992406003088	substrate binding site [chemical binding]; other site
992406003089	oxyanion hole (OAH) forming residues; other site
992406003090	trimer interface [polypeptide binding]; other site
992406003091	DNA repair protein RadA; Provisional; Region: PRK11823
992406003092	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
992406003093	Walker A motif; other site
992406003094	ATP binding site [chemical binding]; other site
992406003095	Walker B motif; other site
992406003096	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
992406003097	Bacterial Ig-like domain; Region: Big_5; pfam13205
992406003098	Haem-binding domain; Region: Haem_bd; pfam14376
992406003099	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406003100	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
992406003101	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
992406003102	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
992406003103	catalytic residues [active]
992406003104	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406003105	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
992406003106	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
992406003107	active site
992406003108	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
992406003109	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
992406003110	BON domain; Region: BON; cl02771
992406003111	Bacterial SH3 domain; Region: SH3_3; pfam08239
992406003112	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
992406003113	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
992406003114	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
992406003115	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
992406003116	Walker A motif; other site
992406003117	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
992406003118	exosortase F-associated protein; Region: flavo_near_exo; TIGR04127
992406003119	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
992406003120	Deoxyhypusine synthase; Region: DS; cl00826
992406003121	deoxyhypusine synthase; Region: dhys; TIGR00321
992406003122	Deoxyhypusine synthase; Region: DS; cl00826
992406003123	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
992406003124	Protein of unknown function (DUF2480); Region: DUF2480; pfam10652
992406003125	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
992406003126	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
992406003127	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
992406003128	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
992406003129	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
992406003130	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
992406003131	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
992406003132	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
992406003133	FMN binding site [chemical binding]; other site
992406003134	substrate binding site [chemical binding]; other site
992406003135	putative catalytic residue [active]
992406003136	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
992406003137	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
992406003138	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
992406003139	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
992406003140	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
992406003141	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
992406003142	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
992406003143	putative catalytic site [active]
992406003144	putative metal binding site [ion binding]; other site
992406003145	putative phosphate binding site [ion binding]; other site
992406003146	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
992406003147	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
992406003148	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
992406003149	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
992406003150	Competence protein; Region: Competence; pfam03772
992406003151	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
992406003152	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
992406003153	putative Iron-sulfur protein interface [polypeptide binding]; other site
992406003154	proximal heme binding site [chemical binding]; other site
992406003155	distal heme binding site [chemical binding]; other site
992406003156	putative dimer interface [polypeptide binding]; other site
992406003157	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
992406003158	L-aspartate oxidase; Provisional; Region: PRK06175
992406003159	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
992406003160	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
992406003161	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
992406003162	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
992406003163	active site
992406003164	DNA polymerase IV; Validated; Region: PRK02406
992406003165	DNA binding site [nucleotide binding]
992406003166	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
992406003167	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
992406003168	hexamer interface [polypeptide binding]; other site
992406003169	Walker A motif; other site
992406003170	ATP binding site [chemical binding]; other site
992406003171	Walker B motif; other site
992406003172	CTP synthetase; Validated; Region: pyrG; PRK05380
992406003173	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
992406003174	Catalytic site [active]
992406003175	active site
992406003176	UTP binding site [chemical binding]; other site
992406003177	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
992406003178	active site
992406003179	putative oxyanion hole; other site
992406003180	catalytic triad [active]
992406003181	membrane protein insertase; Provisional; Region: PRK01318
992406003182	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
992406003183	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
992406003184	RNA/DNA hybrid binding site [nucleotide binding]; other site
992406003185	active site
992406003186	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
992406003187	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
992406003188	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406003189	starch binding outer membrane protein SusD; Region: SusD; cl17845
992406003190	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
992406003191	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
992406003192	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
992406003193	active site
992406003194	HIGH motif; other site
992406003195	KMSK motif region; other site
992406003196	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
992406003197	tRNA binding surface [nucleotide binding]; other site
992406003198	anticodon binding site; other site
992406003199	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
992406003200	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
992406003201	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
992406003202	FeS/SAM binding site; other site
992406003203	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
992406003204	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
992406003205	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
992406003206	putative trimer interface [polypeptide binding]; other site
992406003207	putative CoA binding site [chemical binding]; other site
992406003208	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
992406003209	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
992406003210	homodimer interface [polypeptide binding]; other site
992406003211	metal binding site [ion binding]; metal-binding site
992406003212	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
992406003213	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
992406003214	hinge; other site
992406003215	active site
992406003216	short chain dehydrogenase; Provisional; Region: PRK06179
992406003217	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
992406003218	NADP binding site [chemical binding]; other site
992406003219	active site
992406003220	steroid binding site; other site
992406003221	chaperone protein HchA; Provisional; Region: PRK04155
992406003222	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
992406003223	conserved cys residue [active]
992406003224	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
992406003225	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
992406003226	ligand binding site [chemical binding]; other site
992406003227	flexible hinge region; other site
992406003228	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
992406003229	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
992406003230	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
992406003231	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
992406003232	homodimer interface [polypeptide binding]; other site
992406003233	NADP binding site [chemical binding]; other site
992406003234	substrate binding site [chemical binding]; other site
992406003235	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
992406003236	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
992406003237	active site
992406003238	dimer interface [polypeptide binding]; other site
992406003239	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
992406003240	dimer interface [polypeptide binding]; other site
992406003241	active site
992406003242	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
992406003243	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
992406003244	dimer interface [polypeptide binding]; other site
992406003245	active site
992406003246	glycine-pyridoxal phosphate binding site [chemical binding]; other site
992406003247	folate binding site [chemical binding]; other site
992406003248	RecX family; Region: RecX; pfam02631
992406003249	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
992406003250	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
992406003251	NAD(P) binding site [chemical binding]; other site
992406003252	homodimer interface [polypeptide binding]; other site
992406003253	substrate binding site [chemical binding]; other site
992406003254	active site
992406003255	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
992406003256	SLBB domain; Region: SLBB; pfam10531
992406003257	tyrosine kinase; Provisional; Region: PRK11519
992406003258	Chain length determinant protein; Region: Wzz; pfam02706
992406003259	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
992406003260	Chain length determinant protein; Region: Wzz; cl15801
992406003261	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
992406003262	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
992406003263	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
992406003264	NAD binding site [chemical binding]; other site
992406003265	substrate binding site [chemical binding]; other site
992406003266	homodimer interface [polypeptide binding]; other site
992406003267	active site
992406003268	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
992406003269	four helix bundle protein; Region: TIGR02436
992406003270	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
992406003271	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
992406003272	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
992406003273	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
992406003274	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
992406003275	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
992406003276	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
992406003277	active site
992406003278	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
992406003279	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
992406003280	active site
992406003281	dimer interface [polypeptide binding]; other site
992406003282	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
992406003283	Ligand Binding Site [chemical binding]; other site
992406003284	Molecular Tunnel; other site
992406003285	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
992406003286	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
992406003287	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
992406003288	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
992406003289	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
992406003290	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
992406003291	active site
992406003292	dimer interface [polypeptide binding]; other site
992406003293	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
992406003294	Ligand Binding Site [chemical binding]; other site
992406003295	Molecular Tunnel; other site
992406003296	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
992406003297	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
992406003298	putative ADP-binding pocket [chemical binding]; other site
992406003299	Bacterial sugar transferase; Region: Bac_transf; pfam02397
992406003300	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
992406003301	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
992406003302	putative trimer interface [polypeptide binding]; other site
992406003303	putative CoA binding site [chemical binding]; other site
992406003304	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
992406003305	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
992406003306	inhibitor-cofactor binding pocket; inhibition site
992406003307	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406003308	catalytic residue [active]
992406003309	Bacterial sugar transferase; Region: Bac_transf; cl00939
992406003310	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
992406003311	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
992406003312	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
992406003313	NAD binding site [chemical binding]; other site
992406003314	substrate binding site [chemical binding]; other site
992406003315	homodimer interface [polypeptide binding]; other site
992406003316	active site
992406003317	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
992406003318	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
992406003319	substrate binding site; other site
992406003320	tetramer interface; other site
992406003321	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
992406003322	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
992406003323	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
992406003324	FeS/SAM binding site; other site
992406003325	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
992406003326	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
992406003327	folate binding site [chemical binding]; other site
992406003328	NADP+ binding site [chemical binding]; other site
992406003329	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
992406003330	Repair protein; Region: Repair_PSII; cl01535
992406003331	Repair protein; Region: Repair_PSII; pfam04536
992406003332	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
992406003333	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
992406003334	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
992406003335	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
992406003336	TIGR01777 family protein; Region: yfcH
992406003337	NAD(P) binding site [chemical binding]; other site
992406003338	active site
992406003339	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
992406003340	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
992406003341	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
992406003342	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
992406003343	Coenzyme A binding pocket [chemical binding]; other site
992406003344	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
992406003345	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
992406003346	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
992406003347	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
992406003348	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
992406003349	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
992406003350	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
992406003351	putative dimer interface [polypeptide binding]; other site
992406003352	[2Fe-2S] cluster binding site [ion binding]; other site
992406003353	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
992406003354	SLBB domain; Region: SLBB; pfam10531
992406003355	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
992406003356	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
992406003357	catalytic loop [active]
992406003358	iron binding site [ion binding]; other site
992406003359	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
992406003360	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
992406003361	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
992406003362	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
992406003363	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
992406003364	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
992406003365	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
992406003366	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
992406003367	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
992406003368	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
992406003369	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
992406003370	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
992406003371	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
992406003372	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
992406003373	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
992406003374	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
992406003375	dimer interface [polypeptide binding]; other site
992406003376	catalytic triad [active]
992406003377	peroxidatic and resolving cysteines [active]
992406003378	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
992406003379	NADH(P)-binding; Region: NAD_binding_10; pfam13460
992406003380	NAD binding site [chemical binding]; other site
992406003381	active site
992406003382	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
992406003383	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
992406003384	HSP70 interaction site [polypeptide binding]; other site
992406003385	glycine dehydrogenase; Provisional; Region: PRK05367
992406003386	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
992406003387	tetramer interface [polypeptide binding]; other site
992406003388	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406003389	catalytic residue [active]
992406003390	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
992406003391	tetramer interface [polypeptide binding]; other site
992406003392	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406003393	catalytic residue [active]
992406003394	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
992406003395	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
992406003396	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
992406003397	ABC transporter; Region: ABC_tran_2; pfam12848
992406003398	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
992406003399	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
992406003400	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
992406003401	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
992406003402	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
992406003403	acyl-activating enzyme (AAE) consensus motif; other site
992406003404	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
992406003405	AMP binding site [chemical binding]; other site
992406003406	active site
992406003407	CoA binding site [chemical binding]; other site
992406003408	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
992406003409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406003410	S-adenosylmethionine binding site [chemical binding]; other site
992406003411	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
992406003412	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
992406003413	Glutamate binding site [chemical binding]; other site
992406003414	NAD binding site [chemical binding]; other site
992406003415	catalytic residues [active]
992406003416	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
992406003417	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
992406003418	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
992406003419	active site
992406003420	acetyl-CoA C-acetyltransferase; Region: PLN02644
992406003421	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
992406003422	dimer interface [polypeptide binding]; other site
992406003423	active site
992406003424	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
992406003425	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
992406003426	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
992406003427	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
992406003428	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
992406003429	substrate binding site [chemical binding]; other site
992406003430	ATP binding site [chemical binding]; other site
992406003431	Protein of unknown function (DUF4241); Region: DUF4241; pfam14025
992406003432	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
992406003433	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
992406003434	active site
992406003435	HIGH motif; other site
992406003436	nucleotide binding site [chemical binding]; other site
992406003437	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
992406003438	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
992406003439	active site
992406003440	KMSKS motif; other site
992406003441	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
992406003442	tRNA binding surface [nucleotide binding]; other site
992406003443	anticodon binding site; other site
992406003444	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
992406003445	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
992406003446	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
992406003447	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
992406003448	Ligand binding site; other site
992406003449	Putative Catalytic site; other site
992406003450	DXD motif; other site
992406003451	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
992406003452	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
992406003453	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
992406003454	active site
992406003455	substrate binding site [chemical binding]; other site
992406003456	metal binding site [ion binding]; metal-binding site
992406003457	aspartate aminotransferase; Provisional; Region: PRK05764
992406003458	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
992406003459	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406003460	homodimer interface [polypeptide binding]; other site
992406003461	catalytic residue [active]
992406003462	Bacterial SH3 domain; Region: SH3_3; cl17532
992406003463	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
992406003464	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
992406003465	Ligand binding site; other site
992406003466	oligomer interface; other site
992406003467	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
992406003468	catalytic residues [active]
992406003469	dimer interface [polypeptide binding]; other site
992406003470	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
992406003471	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
992406003472	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
992406003473	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
992406003474	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
992406003475	DNA binding residues [nucleotide binding]
992406003476	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
992406003477	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
992406003478	substrate binding site [chemical binding]; other site
992406003479	hexamer interface [polypeptide binding]; other site
992406003480	metal binding site [ion binding]; metal-binding site
992406003481	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
992406003482	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
992406003483	prolyl-tRNA synthetase; Provisional; Region: PRK08661
992406003484	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
992406003485	dimer interface [polypeptide binding]; other site
992406003486	motif 1; other site
992406003487	active site
992406003488	motif 2; other site
992406003489	motif 3; other site
992406003490	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
992406003491	anticodon binding site; other site
992406003492	zinc-binding site [ion binding]; other site
992406003493	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
992406003494	manganese transport protein MntH; Reviewed; Region: PRK00701
992406003495	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
992406003496	GrpE; Region: GrpE; pfam01025
992406003497	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
992406003498	dimer interface [polypeptide binding]; other site
992406003499	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
992406003500	chaperone protein DnaJ; Provisional; Region: PRK14289
992406003501	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
992406003502	HSP70 interaction site [polypeptide binding]; other site
992406003503	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
992406003504	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
992406003505	dimer interface [polypeptide binding]; other site
992406003506	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
992406003507	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
992406003508	Walker A/P-loop; other site
992406003509	ATP binding site [chemical binding]; other site
992406003510	Q-loop/lid; other site
992406003511	ABC transporter signature motif; other site
992406003512	Walker B; other site
992406003513	D-loop; other site
992406003514	H-loop/switch region; other site
992406003515	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
992406003516	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
992406003517	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
992406003518	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
992406003519	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
992406003520	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
992406003521	fumarylacetoacetase; Region: PLN02856
992406003522	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
992406003523	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
992406003524	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
992406003525	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
992406003526	dimer interface [polypeptide binding]; other site
992406003527	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
992406003528	active site
992406003529	Fe binding site [ion binding]; other site
992406003530	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
992406003531	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
992406003532	purine nucleoside phosphorylase; Provisional; Region: PRK08202
992406003533	replicative DNA helicase; Region: DnaB; TIGR00665
992406003534	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
992406003535	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
992406003536	Walker A motif; other site
992406003537	ATP binding site [chemical binding]; other site
992406003538	Walker B motif; other site
992406003539	DNA binding loops [nucleotide binding]
992406003540	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
992406003541	RNA/DNA hybrid binding site [nucleotide binding]; other site
992406003542	active site
992406003543	Uncharacterized conserved protein [Function unknown]; Region: COG2968
992406003544	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
992406003545	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406003546	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
992406003547	PGAP1-like protein; Region: PGAP1; pfam07819
992406003548	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
992406003549	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
992406003550	active site
992406003551	HIGH motif; other site
992406003552	dimer interface [polypeptide binding]; other site
992406003553	KMSKS motif; other site
992406003554	putative hydrolase; Provisional; Region: PRK11460
992406003555	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
992406003556	AIR carboxylase; Region: AIRC; pfam00731
992406003557	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
992406003558	ATP-grasp domain; Region: ATP-grasp; pfam02222
992406003559	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
992406003560	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
992406003561	putative metal binding site [ion binding]; other site
992406003562	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
992406003563	diphosphomevalonate decarboxylase; Region: PLN02407
992406003564	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
992406003565	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
992406003566	acyl-activating enzyme (AAE) consensus motif; other site
992406003567	putative AMP binding site [chemical binding]; other site
992406003568	putative active site [active]
992406003569	putative CoA binding site [chemical binding]; other site
992406003570	Peptidase family M48; Region: Peptidase_M48; pfam01435
992406003571	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
992406003572	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
992406003573	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
992406003574	Walker A/P-loop; other site
992406003575	ATP binding site [chemical binding]; other site
992406003576	Q-loop/lid; other site
992406003577	ABC transporter signature motif; other site
992406003578	Walker B; other site
992406003579	D-loop; other site
992406003580	H-loop/switch region; other site
992406003581	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
992406003582	Permease; Region: Permease; pfam02405
992406003583	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
992406003584	Bacterial sugar transferase; Region: Bac_transf; pfam02397
992406003585	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
992406003586	RimM N-terminal domain; Region: RimM; pfam01782
992406003587	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
992406003588	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406003589	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
992406003590	dimer interface [polypeptide binding]; other site
992406003591	active site
992406003592	aspartate-rich active site metal binding site; other site
992406003593	allosteric magnesium binding site [ion binding]; other site
992406003594	Schiff base residues; other site
992406003595	glutamate racemase; Provisional; Region: PRK00865
992406003596	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
992406003597	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
992406003598	putative active site [active]
992406003599	substrate binding site [chemical binding]; other site
992406003600	putative cosubstrate binding site; other site
992406003601	catalytic site [active]
992406003602	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
992406003603	substrate binding site [chemical binding]; other site
992406003604	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
992406003605	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
992406003606	ATP binding site [chemical binding]; other site
992406003607	putative Mg++ binding site [ion binding]; other site
992406003608	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
992406003609	nucleotide binding region [chemical binding]; other site
992406003610	ATP-binding site [chemical binding]; other site
992406003611	malate dehydrogenase; Reviewed; Region: PRK06223
992406003612	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
992406003613	dimer interface [polypeptide binding]; other site
992406003614	NAD(P) binding site [chemical binding]; other site
992406003615	tetramer (dimer of dimers) interface [polypeptide binding]; other site
992406003616	substrate binding site [chemical binding]; other site
992406003617	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
992406003618	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
992406003619	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
992406003620	RNase E interface [polypeptide binding]; other site
992406003621	trimer interface [polypeptide binding]; other site
992406003622	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
992406003623	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
992406003624	RNase E interface [polypeptide binding]; other site
992406003625	trimer interface [polypeptide binding]; other site
992406003626	active site
992406003627	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
992406003628	putative nucleic acid binding region [nucleotide binding]; other site
992406003629	G-X-X-G motif; other site
992406003630	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
992406003631	RNA binding site [nucleotide binding]; other site
992406003632	domain interface; other site
992406003633	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
992406003634	16S/18S rRNA binding site [nucleotide binding]; other site
992406003635	S13e-L30e interaction site [polypeptide binding]; other site
992406003636	25S rRNA binding site [nucleotide binding]; other site
992406003637	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
992406003638	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
992406003639	active site
992406003640	catalytic site [active]
992406003641	substrate binding site [chemical binding]; other site
992406003642	DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594
992406003643	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
992406003644	active site
992406003645	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
992406003646	generic binding surface II; other site
992406003647	generic binding surface I; other site
992406003648	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
992406003649	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
992406003650	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
992406003651	putative acyl-acceptor binding pocket; other site
992406003652	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
992406003653	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
992406003654	aspartate kinase; Region: asp_kinases; TIGR00657
992406003655	nucleotide binding site [chemical binding]; other site
992406003656	substrate binding site [chemical binding]; other site
992406003657	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
992406003658	metal binding site [ion binding]; metal-binding site
992406003659	active site
992406003660	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
992406003661	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
992406003662	active site
992406003663	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
992406003664	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
992406003665	Zn2+ binding site [ion binding]; other site
992406003666	Mg2+ binding site [ion binding]; other site
992406003667	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
992406003668	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
992406003669	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
992406003670	trimer interface [polypeptide binding]; other site
992406003671	active site
992406003672	UDP-GlcNAc binding site [chemical binding]; other site
992406003673	lipid binding site [chemical binding]; lipid-binding site
992406003674	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
992406003675	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
992406003676	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
992406003677	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
992406003678	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
992406003679	active site
992406003680	elongation factor P; Validated; Region: PRK00529
992406003681	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
992406003682	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
992406003683	RNA binding site [nucleotide binding]; other site
992406003684	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
992406003685	RNA binding site [nucleotide binding]; other site
992406003686	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
992406003687	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
992406003688	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
992406003689	trimer interface [polypeptide binding]; other site
992406003690	active site
992406003691	UDP-GlcNAc binding site [chemical binding]; other site
992406003692	lipid binding site [chemical binding]; lipid-binding site
992406003693	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
992406003694	CoA binding domain; Region: CoA_binding; smart00881
992406003695	CoA-ligase; Region: Ligase_CoA; pfam00549
992406003696	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
992406003697	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
992406003698	Peptidase family M1; Region: Peptidase_M1; pfam01433
992406003699	Zn binding site [ion binding]; other site
992406003700	HEAT repeats; Region: HEAT_2; pfam13646
992406003701	thymidylate synthase; Reviewed; Region: thyA; PRK01827
992406003702	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
992406003703	dimerization interface [polypeptide binding]; other site
992406003704	active site
992406003705	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406003706	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
992406003707	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406003708	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
992406003709	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
992406003710	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
992406003711	FMN binding site [chemical binding]; other site
992406003712	active site
992406003713	catalytic residues [active]
992406003714	substrate binding site [chemical binding]; other site
992406003715	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
992406003716	putative active site [active]
992406003717	putative catalytic site [active]
992406003718	putative DNA binding site [nucleotide binding]; other site
992406003719	putative phosphate binding site [ion binding]; other site
992406003720	metal binding site A [ion binding]; metal-binding site
992406003721	putative AP binding site [nucleotide binding]; other site
992406003722	putative metal binding site B [ion binding]; other site
992406003723	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
992406003724	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
992406003725	trigger factor; Region: tig; TIGR00115
992406003726	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
992406003727	Cna protein B-type domain; Region: Cna_B_2; pfam13715
992406003728	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
992406003729	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406003730	6-phosphofructokinase; Provisional; Region: PRK03202
992406003731	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
992406003732	active site
992406003733	ADP/pyrophosphate binding site [chemical binding]; other site
992406003734	dimerization interface [polypeptide binding]; other site
992406003735	allosteric effector site; other site
992406003736	fructose-1,6-bisphosphate binding site; other site
992406003737	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
992406003738	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
992406003739	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
992406003740	recA bacterial DNA recombination protein; Region: RecA; cl17211
992406003741	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
992406003742	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
992406003743	active site
992406003744	metal binding site [ion binding]; metal-binding site
992406003745	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406003746	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
992406003747	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
992406003748	alpha subunit interface [polypeptide binding]; other site
992406003749	TPP binding site [chemical binding]; other site
992406003750	heterodimer interface [polypeptide binding]; other site
992406003751	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
992406003752	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
992406003753	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
992406003754	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
992406003755	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
992406003756	RNA binding site [nucleotide binding]; other site
992406003757	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
992406003758	MutS domain III; Region: MutS_III; pfam05192
992406003759	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
992406003760	Walker A/P-loop; other site
992406003761	ATP binding site [chemical binding]; other site
992406003762	Q-loop/lid; other site
992406003763	ABC transporter signature motif; other site
992406003764	Walker B; other site
992406003765	D-loop; other site
992406003766	H-loop/switch region; other site
992406003767	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
992406003768	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
992406003769	catalytic residues [active]
992406003770	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406003771	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
992406003772	ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]; Region: ClpX; COG1219
992406003773	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406003774	Walker A motif; other site
992406003775	ATP binding site [chemical binding]; other site
992406003776	Walker B motif; other site
992406003777	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
992406003778	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
992406003779	nucleotide binding site/active site [active]
992406003780	HIT family signature motif; other site
992406003781	catalytic residue [active]
992406003782	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
992406003783	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
992406003784	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
992406003785	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
992406003786	dimerization interface [polypeptide binding]; other site
992406003787	putative tRNAtyr binding site [nucleotide binding]; other site
992406003788	putative active site [active]
992406003789	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
992406003790	catalytic center binding site [active]
992406003791	ATP binding site [chemical binding]; other site
992406003792	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
992406003793	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
992406003794	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
992406003795	ligand binding site [chemical binding]; other site
992406003796	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
992406003797	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
992406003798	ligand binding site [chemical binding]; other site
992406003799	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
992406003800	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
992406003801	active site
992406003802	Zn binding site [ion binding]; other site
992406003803	Protein of unknown function (DUF456); Region: DUF456; pfam04306
992406003804	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
992406003805	Mechanosensitive ion channel; Region: MS_channel; pfam00924
992406003806	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
992406003807	active site
992406003808	hydrophilic channel; other site
992406003809	dimerization interface [polypeptide binding]; other site
992406003810	catalytic residues [active]
992406003811	active site lid [active]
992406003812	PGAP1-like protein; Region: PGAP1; pfam07819
992406003813	acyl-CoA esterase; Provisional; Region: PRK10673
992406003814	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
992406003815	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
992406003816	NAD(P) binding site [chemical binding]; other site
992406003817	active site
992406003818	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
992406003819	Sulfatase; Region: Sulfatase; cl17466
992406003820	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
992406003821	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
992406003822	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
992406003823	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
992406003824	amidase catalytic site [active]
992406003825	Zn binding residues [ion binding]; other site
992406003826	substrate binding site [chemical binding]; other site
992406003827	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
992406003828	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
992406003829	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
992406003830	polyphosphate kinase; Provisional; Region: PRK05443
992406003831	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
992406003832	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
992406003833	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
992406003834	domain interface [polypeptide binding]; other site
992406003835	active site
992406003836	catalytic site [active]
992406003837	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
992406003838	putative active site [active]
992406003839	catalytic site [active]
992406003840	exopolyphosphatase; Region: exo_poly_only; TIGR03706
992406003841	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
992406003842	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
992406003843	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
992406003844	N-terminal plug; other site
992406003845	ligand-binding site [chemical binding]; other site
992406003846	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
992406003847	Domain of unknown function (DUF1832); Region: DUF1832; cl07463
992406003848	AAA-like domain; Region: AAA_10; pfam12846
992406003849	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406003850	Walker A motif; other site
992406003851	ATP binding site [chemical binding]; other site
992406003852	Walker B motif; other site
992406003853	putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183
992406003854	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
992406003855	Active Sites [active]
992406003856	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
992406003857	Ligand Binding Site [chemical binding]; other site
992406003858	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
992406003859	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
992406003860	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
992406003861	active site
992406003862	catalytic site [active]
992406003863	substrate binding site [chemical binding]; other site
992406003864	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
992406003865	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
992406003866	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
992406003867	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
992406003868	active site
992406003869	Zn binding site [ion binding]; other site
992406003870	competence damage-inducible protein A; Provisional; Region: PRK00549
992406003871	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
992406003872	putative MPT binding site; other site
992406003873	Competence-damaged protein; Region: CinA; pfam02464
992406003874	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
992406003875	Alkaline phosphatase homologues; Region: alkPPc; smart00098
992406003876	active site
992406003877	dimer interface [polypeptide binding]; other site
992406003878	Endonuclease I; Region: Endonuclease_1; pfam04231
992406003879	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406003880	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
992406003881	FtsX-like permease family; Region: FtsX; pfam02687
992406003882	Ribosome-binding factor A; Region: RBFA; pfam02033
992406003883	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
992406003884	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
992406003885	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
992406003886	DNA binding residues [nucleotide binding]
992406003887	lipoyl synthase; Provisional; Region: PRK05481
992406003888	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
992406003889	FeS/SAM binding site; other site
992406003890	Uncharacterized conserved protein [Function unknown]; Region: COG3339
992406003891	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
992406003892	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
992406003893	catalytic residues [active]
992406003894	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
992406003895	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
992406003896	Tetramer interface [polypeptide binding]; other site
992406003897	active site
992406003898	FMN-binding site [chemical binding]; other site
992406003899	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
992406003900	putative catalytic site [active]
992406003901	putative metal binding site [ion binding]; other site
992406003902	putative phosphate binding site [ion binding]; other site
992406003903	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
992406003904	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
992406003905	metal binding site [ion binding]; metal-binding site
992406003906	dimer interface [polypeptide binding]; other site
992406003907	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
992406003908	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
992406003909	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
992406003910	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
992406003911	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
992406003912	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
992406003913	IHF - DNA interface [nucleotide binding]; other site
992406003914	IHF dimer interface [polypeptide binding]; other site
992406003915	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
992406003916	tetramerization interface [polypeptide binding]; other site
992406003917	active site
992406003918	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
992406003919	cytidylate kinase; Provisional; Region: cmk; PRK00023
992406003920	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
992406003921	CMP-binding site; other site
992406003922	The sites determining sugar specificity; other site
992406003923	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
992406003924	dihydropteroate synthase; Region: DHPS; TIGR01496
992406003925	substrate binding pocket [chemical binding]; other site
992406003926	dimer interface [polypeptide binding]; other site
992406003927	inhibitor binding site; inhibition site
992406003928	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
992406003929	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
992406003930	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
992406003931	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
992406003932	Walker A/P-loop; other site
992406003933	ATP binding site [chemical binding]; other site
992406003934	Q-loop/lid; other site
992406003935	ABC transporter signature motif; other site
992406003936	Walker B; other site
992406003937	D-loop; other site
992406003938	H-loop/switch region; other site
992406003939	hypothetical protein; Reviewed; Region: PRK00024
992406003940	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
992406003941	MPN+ (JAMM) motif; other site
992406003942	Zinc-binding site [ion binding]; other site
992406003943	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
992406003944	dimer interface [polypeptide binding]; other site
992406003945	substrate binding site [chemical binding]; other site
992406003946	metal binding sites [ion binding]; metal-binding site
992406003947	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
992406003948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
992406003949	Walker A motif; other site
992406003950	ATP binding site [chemical binding]; other site
992406003951	DNA polymerase III subunit delta'; Validated; Region: PRK08485
992406003952	Walker B motif; other site
992406003953	arginine finger; other site
992406003954	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
992406003955	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
992406003956	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
992406003957	Chorismate mutase type II; Region: CM_2; smart00830
992406003958	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
992406003959	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
992406003960	The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843
992406003961	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
992406003962	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
992406003963	THF binding site; other site
992406003964	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
992406003965	substrate binding site [chemical binding]; other site
992406003966	THF binding site; other site
992406003967	zinc-binding site [ion binding]; other site
992406003968	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
992406003969	Phosphate transporter family; Region: PHO4; pfam01384
992406003970	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
992406003971	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
992406003972	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
992406003973	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
992406003974	Penicillinase repressor; Region: Pencillinase_R; cl17580
992406003975	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
992406003976	nudix motif; other site
992406003977	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
992406003978	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
992406003979	substrate binding pocket [chemical binding]; other site
992406003980	chain length determination region; other site
992406003981	substrate-Mg2+ binding site; other site
992406003982	catalytic residues [active]
992406003983	aspartate-rich region 1; other site
992406003984	active site lid residues [active]
992406003985	aspartate-rich region 2; other site
992406003986	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
992406003987	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
992406003988	Zn binding site [ion binding]; other site
992406003989	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
992406003990	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
992406003991	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
992406003992	catalytic residue [active]
992406003993	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
992406003994	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
992406003995	PhnA protein; Region: PhnA; pfam03831
992406003996	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
992406003997	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
992406003998	Walker A/P-loop; other site
992406003999	ATP binding site [chemical binding]; other site
992406004000	Q-loop/lid; other site
992406004001	ABC transporter signature motif; other site
992406004002	Walker B; other site
992406004003	D-loop; other site
992406004004	H-loop/switch region; other site
992406004005	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
992406004006	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
992406004007	generic binding surface II; other site
992406004008	ssDNA binding site; other site
992406004009	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
992406004010	ATP binding site [chemical binding]; other site
992406004011	putative Mg++ binding site [ion binding]; other site
992406004012	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
992406004013	nucleotide binding region [chemical binding]; other site
992406004014	ATP-binding site [chemical binding]; other site
992406004015	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
992406004016	RNA binding surface [nucleotide binding]; other site
992406004017	potential frameshift: common BLAST hit: gi|383485306|ref|YP_005394218.1| shikimate kinase
992406004018	shikimate kinase II; Reviewed; Region: aroL; cl17327
992406004019	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
992406004020	active site
992406004021	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406004022	S-adenosylmethionine binding site [chemical binding]; other site
992406004023	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
992406004024	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
992406004025	ligand binding site [chemical binding]; other site
992406004026	hypothetical protein; Provisional; Region: PRK08201
992406004027	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
992406004028	metal binding site [ion binding]; metal-binding site
992406004029	putative dimer interface [polypeptide binding]; other site
992406004030	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
992406004031	Methyltransferase domain; Region: Methyltransf_23; pfam13489
992406004032	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406004033	S-adenosylmethionine binding site [chemical binding]; other site
992406004034	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
992406004035	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
992406004036	dimerization interface [polypeptide binding]; other site
992406004037	putative ATP binding site [chemical binding]; other site
992406004038	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
992406004039	thiamine phosphate binding site [chemical binding]; other site
992406004040	active site
992406004041	pyrophosphate binding site [ion binding]; other site
992406004042	Trm112p-like protein; Region: Trm112p; cl01066
992406004043	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
992406004044	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
992406004045	substrate binding pocket [chemical binding]; other site
992406004046	chain length determination region; other site
992406004047	substrate-Mg2+ binding site; other site
992406004048	catalytic residues [active]
992406004049	aspartate-rich region 1; other site
992406004050	active site lid residues [active]
992406004051	aspartate-rich region 2; other site
992406004052	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
992406004053	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
992406004054	NAD(P) binding site [chemical binding]; other site
992406004055	active site
992406004056	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
992406004057	PrcB C-terminal; Region: PrcB_C; pfam14343
992406004058	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
992406004059	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
992406004060	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
992406004061	catalytic residue [active]
992406004062	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
992406004063	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
992406004064	catalytic residues [active]
992406004065	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
992406004066	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
992406004067	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
992406004068	Penicillinase repressor; Region: Pencillinase_R; pfam03965
992406004069	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
992406004070	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
992406004071	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
992406004072	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
992406004073	dimer interface [polypeptide binding]; other site
992406004074	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406004075	catalytic residue [active]
992406004076	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
992406004077	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
992406004078	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
992406004079	substrate-cofactor binding pocket; other site
992406004080	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406004081	catalytic residue [active]
992406004082	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
992406004083	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
992406004084	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
992406004085	primosomal protein N' Region: priA; TIGR00595
992406004086	ATP binding site [chemical binding]; other site
992406004087	putative Mg++ binding site [ion binding]; other site
992406004088	helicase superfamily c-terminal domain; Region: HELICc; smart00490
992406004089	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
992406004090	Domain of unknown function (DUF955); Region: DUF955; cl01076
992406004091	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
992406004092	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
992406004093	nucleotide binding site [chemical binding]; other site
992406004094	NEF interaction site [polypeptide binding]; other site
992406004095	SBD interface [polypeptide binding]; other site
992406004096	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
992406004097	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
992406004098	putative ion selectivity filter; other site
992406004099	putative pore gating glutamate residue; other site
992406004100	putative H+/Cl- coupling transport residue; other site
992406004101	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
992406004102	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
992406004103	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
992406004104	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
992406004105	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
992406004106	WYL domain; Region: WYL; pfam13280
992406004107	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
992406004108	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
992406004109	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
992406004110	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
992406004111	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
992406004112	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
992406004113	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
992406004114	FeS/SAM binding site; other site
992406004115	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
992406004116	DEAD-like helicases superfamily; Region: DEXDc; smart00487
992406004117	ATP binding site [chemical binding]; other site
992406004118	Mg++ binding site [ion binding]; other site
992406004119	motif III; other site
992406004120	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
992406004121	nucleotide binding region [chemical binding]; other site
992406004122	ATP-binding site [chemical binding]; other site
992406004123	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
992406004124	DNA-binding site [nucleotide binding]; DNA binding site
992406004125	RNA-binding motif; other site
992406004126	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
992406004127	DNA-binding site [nucleotide binding]; DNA binding site
992406004128	RNA-binding motif; other site
992406004129	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
992406004130	active site
992406004131	homodimer interface [polypeptide binding]; other site
992406004132	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
992406004133	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
992406004134	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
992406004135	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
992406004136	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
992406004137	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
992406004138	catalytic site [active]
992406004139	subunit interface [polypeptide binding]; other site
992406004140	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
992406004141	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
992406004142	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
992406004143	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
992406004144	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
992406004145	ATP-grasp domain; Region: ATP-grasp_4; cl17255
992406004146	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
992406004147	IMP binding site; other site
992406004148	dimer interface [polypeptide binding]; other site
992406004149	interdomain contacts; other site
992406004150	partial ornithine binding site; other site
992406004151	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
992406004152	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
992406004153	Walker A/P-loop; other site
992406004154	ATP binding site [chemical binding]; other site
992406004155	Q-loop/lid; other site
992406004156	ABC transporter signature motif; other site
992406004157	Walker B; other site
992406004158	D-loop; other site
992406004159	H-loop/switch region; other site
992406004160	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
992406004161	ABC-ATPase subunit  interface; other site
992406004162	dimer interface [polypeptide binding]; other site
992406004163	putative PBP binding regions; other site
992406004164	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
992406004165	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
992406004166	catalytic residues [active]
992406004167	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
992406004168	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
992406004169	FAD binding pocket [chemical binding]; other site
992406004170	FAD binding motif [chemical binding]; other site
992406004171	phosphate binding motif [ion binding]; other site
992406004172	beta-alpha-beta structure motif; other site
992406004173	NAD(p) ribose binding residues [chemical binding]; other site
992406004174	NAD binding pocket [chemical binding]; other site
992406004175	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
992406004176	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
992406004177	catalytic loop [active]
992406004178	iron binding site [ion binding]; other site
992406004179	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
992406004180	putative active site [active]
992406004181	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
992406004182	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
992406004183	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
992406004184	active site
992406004185	HIGH motif; other site
992406004186	nucleotide binding site [chemical binding]; other site
992406004187	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
992406004188	active site
992406004189	KMSKS motif; other site
992406004190	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
992406004191	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
992406004192	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
992406004193	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
992406004194	YceG-like family; Region: YceG; pfam02618
992406004195	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
992406004196	dimerization interface [polypeptide binding]; other site
992406004197	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
992406004198	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
992406004199	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406004200	potential frameshift: common BLAST hit: gi|383485247|ref|YP_005394159.1| methylateD-DNA/protein-cysteinemethyltransferase
992406004201	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
992406004202	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
992406004203	DNA binding site [nucleotide binding]
992406004204	active site
992406004205	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
992406004206	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
992406004207	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
992406004208	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
992406004209	active site
992406004210	metal binding site [ion binding]; metal-binding site
992406004211	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406004212	Recombination protein O N terminal; Region: RecO_N; pfam11967
992406004213	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
992406004214	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
992406004215	active site
992406004216	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
992406004217	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
992406004218	Major Facilitator Superfamily; Region: MFS_1; pfam07690
992406004219	putative substrate translocation pore; other site
992406004220	ATP synthase A chain; Region: ATP-synt_A; cl00413
992406004221	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
992406004222	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
992406004223	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
992406004224	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
992406004225	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
992406004226	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
992406004227	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
992406004228	beta subunit interaction interface [polypeptide binding]; other site
992406004229	Walker A motif; other site
992406004230	ATP binding site [chemical binding]; other site
992406004231	Walker B motif; other site
992406004232	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
992406004233	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
992406004234	core domain interface [polypeptide binding]; other site
992406004235	delta subunit interface [polypeptide binding]; other site
992406004236	epsilon subunit interface [polypeptide binding]; other site
992406004237	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
992406004238	Domain of unknown function DUF21; Region: DUF21; pfam01595
992406004239	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
992406004240	Transporter associated domain; Region: CorC_HlyC; smart01091
992406004241	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
992406004242	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
992406004243	hydrophobic ligand binding site; other site
992406004244	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
992406004245	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
992406004246	TPP-binding site [chemical binding]; other site
992406004247	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
992406004248	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
992406004249	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
992406004250	E3 interaction surface; other site
992406004251	lipoyl attachment site [posttranslational modification]; other site
992406004252	e3 binding domain; Region: E3_binding; pfam02817
992406004253	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
992406004254	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
992406004255	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
992406004256	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
992406004257	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
992406004258	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
992406004259	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
992406004260	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
992406004261	recombination protein F; Reviewed; Region: recF; PRK00064
992406004262	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
992406004263	Walker A/P-loop; other site
992406004264	ATP binding site [chemical binding]; other site
992406004265	Q-loop/lid; other site
992406004266	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
992406004267	ABC transporter signature motif; other site
992406004268	Walker B; other site
992406004269	D-loop; other site
992406004270	H-loop/switch region; other site
992406004271	Cna protein B-type domain; Region: Cna_B_2; pfam13715
992406004272	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
992406004273	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
992406004274	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
992406004275	Putative zinc ribbon domain; Region: DUF164; pfam02591
992406004276	Uncharacterized conserved protein [Function unknown]; Region: COG0327
992406004277	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
992406004278	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
992406004279	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
992406004280	Ion transport protein; Region: Ion_trans; pfam00520
992406004281	Ion channel; Region: Ion_trans_2; pfam07885
992406004282	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
992406004283	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
992406004284	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
992406004285	G1 box; other site
992406004286	putative GEF interaction site [polypeptide binding]; other site
992406004287	GTP/Mg2+ binding site [chemical binding]; other site
992406004288	Switch I region; other site
992406004289	G2 box; other site
992406004290	G3 box; other site
992406004291	Switch II region; other site
992406004292	G4 box; other site
992406004293	G5 box; other site
992406004294	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
992406004295	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
992406004296	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
992406004297	acyl-activating enzyme (AAE) consensus motif; other site
992406004298	putative AMP binding site [chemical binding]; other site
992406004299	putative active site [active]
992406004300	putative CoA binding site [chemical binding]; other site
992406004301	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
992406004302	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
992406004303	FAD binding site [chemical binding]; other site
992406004304	homotetramer interface [polypeptide binding]; other site
992406004305	substrate binding pocket [chemical binding]; other site
992406004306	catalytic base [active]
992406004307	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
992406004308	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
992406004309	dimer interface [polypeptide binding]; other site
992406004310	active site
992406004311	metal binding site [ion binding]; metal-binding site
992406004312	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
992406004313	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
992406004314	ATP binding site [chemical binding]; other site
992406004315	Mg++ binding site [ion binding]; other site
992406004316	motif III; other site
992406004317	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
992406004318	nucleotide binding region [chemical binding]; other site
992406004319	ATP-binding site [chemical binding]; other site
992406004320	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
992406004321	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
992406004322	active site
992406004323	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
992406004324	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
992406004325	active site
992406004326	HIGH motif; other site
992406004327	KMSKS motif; other site
992406004328	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
992406004329	tRNA binding surface [nucleotide binding]; other site
992406004330	anticodon binding site; other site
992406004331	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
992406004332	dimer interface [polypeptide binding]; other site
992406004333	putative tRNA-binding site [nucleotide binding]; other site
992406004334	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
992406004335	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
992406004336	tetramer interface [polypeptide binding]; other site
992406004337	active site
992406004338	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
992406004339	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
992406004340	intersubunit interface [polypeptide binding]; other site
992406004341	Domain of unknown function (DUF4268); Region: DUF4268; pfam14088
992406004342	Peptidase S46; Region: Peptidase_S46; pfam10459
992406004343	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
992406004344	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
992406004345	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
992406004346	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
992406004347	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
992406004348	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
992406004349	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
992406004350	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
992406004351	tetramer interface [polypeptide binding]; other site
992406004352	TPP-binding site [chemical binding]; other site
992406004353	heterodimer interface [polypeptide binding]; other site
992406004354	phosphorylation loop region [posttranslational modification]
992406004355	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
992406004356	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
992406004357	PYR/PP interface [polypeptide binding]; other site
992406004358	dimer interface [polypeptide binding]; other site
992406004359	TPP binding site [chemical binding]; other site
992406004360	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
992406004361	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
992406004362	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
992406004363	inhibitor-cofactor binding pocket; inhibition site
992406004364	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406004365	catalytic residue [active]
992406004366	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
992406004367	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
992406004368	NAD binding site [chemical binding]; other site
992406004369	homodimer interface [polypeptide binding]; other site
992406004370	active site
992406004371	substrate binding site [chemical binding]; other site
992406004372	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
992406004373	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
992406004374	active site
992406004375	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
992406004376	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406004377	S-adenosylmethionine binding site [chemical binding]; other site
992406004378	DNA polymerase III subunit beta; Validated; Region: PRK05643
992406004379	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
992406004380	putative DNA binding surface [nucleotide binding]; other site
992406004381	dimer interface [polypeptide binding]; other site
992406004382	beta-clamp/clamp loader binding surface; other site
992406004383	beta-clamp/translesion DNA polymerase binding surface; other site
992406004384	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
992406004385	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
992406004386	putative tRNA-binding site [nucleotide binding]; other site
992406004387	B3/4 domain; Region: B3_4; pfam03483
992406004388	tRNA synthetase B5 domain; Region: B5; pfam03484
992406004389	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
992406004390	dimer interface [polypeptide binding]; other site
992406004391	motif 1; other site
992406004392	motif 3; other site
992406004393	motif 2; other site
992406004394	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
992406004395	META domain; Region: META; pfam03724
992406004396	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
992406004397	oligomerisation interface [polypeptide binding]; other site
992406004398	mobile loop; other site
992406004399	roof hairpin; other site
992406004400	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
992406004401	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
992406004402	ring oligomerisation interface [polypeptide binding]; other site
992406004403	ATP/Mg binding site [chemical binding]; other site
992406004404	stacking interactions; other site
992406004405	hinge regions; other site
992406004406	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
992406004407	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
992406004408	NAD(P) binding site [chemical binding]; other site
992406004409	active site
992406004410	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
992406004411	Coenzyme A binding pocket [chemical binding]; other site
992406004412	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
992406004413	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
992406004414	PYR/PP interface [polypeptide binding]; other site
992406004415	dimer interface [polypeptide binding]; other site
992406004416	TPP binding site [chemical binding]; other site
992406004417	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
992406004418	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
992406004419	active site
992406004420	homotetramer interface [polypeptide binding]; other site
992406004421	Domain of unknown function (DUF336); Region: DUF336; cl01249
992406004422	Domain of unknown function (DUF336); Region: DUF336; pfam03928
992406004423	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
992406004424	active site
992406004425	homotetramer interface [polypeptide binding]; other site
992406004426	Domain of unknown function (DUF336); Region: DUF336; cl01249
992406004427	Predicted membrane protein [Function unknown]; Region: COG3059
992406004428	Domain of unknown function (DUF336); Region: DUF336; pfam03928
992406004429	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
992406004430	transketolase; Reviewed; Region: PRK05899
992406004431	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
992406004432	TPP-binding site [chemical binding]; other site
992406004433	dimer interface [polypeptide binding]; other site
992406004434	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
992406004435	Na binding site [ion binding]; other site
992406004436	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
992406004437	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
992406004438	FeS/SAM binding site; other site
992406004439	HemN C-terminal domain; Region: HemN_C; pfam06969
992406004440	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
992406004441	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
992406004442	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
992406004443	Protein export membrane protein; Region: SecD_SecF; pfam02355
992406004444	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
992406004445	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
992406004446	TrkA-C domain; Region: TrkA_C; pfam02080
992406004447	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
992406004448	Ligand Binding Site [chemical binding]; other site
992406004449	prephenate dehydratase; Provisional; Region: PRK11898
992406004450	Prephenate dehydratase; Region: PDT; pfam00800
992406004451	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
992406004452	putative L-Phe binding site [chemical binding]; other site
992406004453	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
992406004454	active site
992406004455	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
992406004456	active site
992406004457	motif I; other site
992406004458	motif II; other site
992406004459	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
992406004460	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
992406004461	Isochorismatase family; Region: Isochorismatase; pfam00857
992406004462	catalytic triad [active]
992406004463	metal binding site [ion binding]; metal-binding site
992406004464	conserved cis-peptide bond; other site
992406004465	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
992406004466	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
992406004467	dimer interface [polypeptide binding]; other site
992406004468	motif 1; other site
992406004469	active site
992406004470	motif 2; other site
992406004471	motif 3; other site
992406004472	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
992406004473	anticodon binding site; other site
992406004474	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
992406004475	ArsC family; Region: ArsC; pfam03960
992406004476	catalytic residues [active]
992406004477	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
992406004478	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
992406004479	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
992406004480	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
992406004481	putative acyl-acceptor binding pocket; other site
992406004482	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
992406004483	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
992406004484	Probable Catalytic site; other site
992406004485	metal-binding site
992406004486	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
992406004487	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
992406004488	DNA binding residues [nucleotide binding]
992406004489	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
992406004490	Coenzyme A binding pocket [chemical binding]; other site
992406004491	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
992406004492	active site
992406004493	catalytic motif [active]
992406004494	Zn binding site [ion binding]; other site
992406004495	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
992406004496	metal binding site [ion binding]; metal-binding site
992406004497	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
992406004498	catalytic residues [active]
992406004499	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
992406004500	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
992406004501	TAP-like protein; Region: Abhydrolase_4; pfam08386
992406004502	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
992406004503	non-specific DNA binding site [nucleotide binding]; other site
992406004504	salt bridge; other site
992406004505	sequence-specific DNA binding site [nucleotide binding]; other site
992406004506	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
992406004507	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239
992406004508	putative active site [active]
992406004509	Zn binding site [ion binding]; other site
992406004510	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406004511	S-adenosylmethionine binding site [chemical binding]; other site
992406004512	hypothetical protein; Provisional; Region: PRK06753
992406004513	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
992406004514	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
992406004515	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
992406004516	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
992406004517	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
992406004518	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
992406004519	active site
992406004520	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
992406004521	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
992406004522	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
992406004523	active site
992406004524	DNA binding site [nucleotide binding]
992406004525	Int/Topo IB signature motif; other site
992406004526	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
992406004527	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
992406004528	dimer interface [polypeptide binding]; other site
992406004529	ssDNA binding site [nucleotide binding]; other site
992406004530	tetramer (dimer of dimers) interface [polypeptide binding]; other site
992406004531	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
992406004532	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
992406004533	ATP binding site [chemical binding]; other site
992406004534	Mg2+ binding site [ion binding]; other site
992406004535	G-X-G motif; other site
992406004536	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
992406004537	anchoring element; other site
992406004538	dimer interface [polypeptide binding]; other site
992406004539	ATP binding site [chemical binding]; other site
992406004540	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
992406004541	active site
992406004542	putative metal-binding site [ion binding]; other site
992406004543	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
992406004544	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
992406004545	DNA gyrase subunit A; Validated; Region: PRK05560
992406004546	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
992406004547	CAP-like domain; other site
992406004548	active site
992406004549	primary dimer interface [polypeptide binding]; other site
992406004550	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
992406004551	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
992406004552	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
992406004553	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
992406004554	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
992406004555	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
992406004556	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
992406004557	TPR motif; other site
992406004558	binding surface
992406004559	TPR repeat; Region: TPR_11; pfam13414
992406004560	YtxH-like protein; Region: YtxH; cl02079
992406004561	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
992406004562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
992406004563	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
992406004564	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
992406004565	active site
992406004566	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
992406004567	RNAase interaction site [polypeptide binding]; other site
992406004568	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
992406004569	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
992406004570	active site
992406004571	Zn binding site [ion binding]; other site
992406004572	Cna protein B-type domain; Region: Cna_B_2; pfam13715
992406004573	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
992406004574	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
992406004575	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
992406004576	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
992406004577	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
992406004578	UbiA prenyltransferase family; Region: UbiA; pfam01040
992406004579	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
992406004580	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
992406004581	substrate binding site [chemical binding]; other site
992406004582	oxyanion hole (OAH) forming residues; other site
992406004583	trimer interface [polypeptide binding]; other site
992406004584	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
992406004585	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
992406004586	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
992406004587	HlyD family secretion protein; Region: HlyD_3; pfam13437
992406004588	Outer membrane efflux protein; Region: OEP; pfam02321
992406004589	Outer membrane efflux protein; Region: OEP; pfam02321
992406004590	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
992406004591	Cytochrome c; Region: Cytochrom_C; cl11414
992406004592	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
992406004593	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
992406004594	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
992406004595	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
992406004596	active site
992406004597	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
992406004598	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
992406004599	RNA binding site [nucleotide binding]; other site
992406004600	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
992406004601	RNA binding site [nucleotide binding]; other site
992406004602	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
992406004603	RNA binding site [nucleotide binding]; other site
992406004604	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
992406004605	RNA binding site [nucleotide binding]; other site
992406004606	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
992406004607	RNA binding site [nucleotide binding]; other site
992406004608	S1 RNA binding domain; Region: S1; pfam00575
992406004609	RNA binding site [nucleotide binding]; other site
992406004610	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
992406004611	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
992406004612	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
992406004613	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
992406004614	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
992406004615	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
992406004616	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
992406004617	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
992406004618	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
992406004619	purine monophosphate binding site [chemical binding]; other site
992406004620	dimer interface [polypeptide binding]; other site
992406004621	putative catalytic residues [active]
992406004622	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
992406004623	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
992406004624	hypothetical protein; Validated; Region: PRK02101
992406004625	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
992406004626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
992406004627	S-adenosylmethionine binding site [chemical binding]; other site
992406004628	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
992406004629	signal recognition particle protein; Provisional; Region: PRK10867
992406004630	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
992406004631	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
992406004632	P loop; other site
992406004633	GTP binding site [chemical binding]; other site
992406004634	Signal peptide binding domain; Region: SRP_SPB; pfam02978
992406004635	Sodium Bile acid symporter family; Region: SBF; cl17470
992406004636	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
992406004637	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
992406004638	dimerization interface [polypeptide binding]; other site
992406004639	putative DNA binding site [nucleotide binding]; other site
992406004640	putative Zn2+ binding site [ion binding]; other site
992406004641	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
992406004642	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
992406004643	triosephosphate isomerase; Provisional; Region: PRK14567
992406004644	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
992406004645	substrate binding site [chemical binding]; other site
992406004646	dimer interface [polypeptide binding]; other site
992406004647	catalytic triad [active]
992406004648	GTPase RsgA; Reviewed; Region: PRK00098
992406004649	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
992406004650	RNA binding site [nucleotide binding]; other site
992406004651	homodimer interface [polypeptide binding]; other site
992406004652	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
992406004653	GTPase/Zn-binding domain interface [polypeptide binding]; other site
992406004654	GTP/Mg2+ binding site [chemical binding]; other site
992406004655	G4 box; other site
992406004656	G5 box; other site
992406004657	G1 box; other site
992406004658	Switch I region; other site
992406004659	G2 box; other site
992406004660	G3 box; other site
992406004661	Switch II region; other site
992406004662	Septum formation initiator; Region: DivIC; cl17659
992406004663	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
992406004664	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
992406004665	ATP-binding site [chemical binding]; other site
992406004666	Sugar specificity; other site
992406004667	Pyrimidine base specificity; other site
992406004668	Protein of unknown function (DUF465); Region: DUF465; cl01070
992406004669	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
992406004670	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
992406004671	G1 box; other site
992406004672	putative GEF interaction site [polypeptide binding]; other site
992406004673	GTP/Mg2+ binding site [chemical binding]; other site
992406004674	Switch I region; other site
992406004675	G2 box; other site
992406004676	G3 box; other site
992406004677	Switch II region; other site
992406004678	G4 box; other site
992406004679	G5 box; other site
992406004680	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
992406004681	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
992406004682	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
992406004683	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
992406004684	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
992406004685	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
992406004686	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
992406004687	GDP-binding site [chemical binding]; other site
992406004688	ACT binding site; other site
992406004689	IMP binding site; other site
992406004690	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
992406004691	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
992406004692	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
992406004693	dimer interface [polypeptide binding]; other site
992406004694	putative anticodon binding site; other site
992406004695	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
992406004696	motif 1; other site
992406004697	active site
992406004698	motif 2; other site
992406004699	motif 3; other site
992406004700	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
992406004701	putative active site [active]
992406004702	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
992406004703	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
992406004704	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
992406004705	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
992406004706	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
992406004707	active site
992406004708	tetramer interface [polypeptide binding]; other site
992406004709	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
992406004710	active site
992406004711	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
992406004712	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
992406004713	ATP binding site [chemical binding]; other site
992406004714	active site
992406004715	substrate binding site [chemical binding]; other site
992406004716	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
992406004717	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
992406004718	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
992406004719	dimerization interface [polypeptide binding]; other site
992406004720	ATP binding site [chemical binding]; other site
992406004721	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
992406004722	dimerization interface [polypeptide binding]; other site
992406004723	ATP binding site [chemical binding]; other site
992406004724	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
992406004725	putative active site [active]
992406004726	catalytic triad [active]
992406004727	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
992406004728	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
992406004729	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
992406004730	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
992406004731	23S rRNA binding site [nucleotide binding]; other site
992406004732	L21 binding site [polypeptide binding]; other site
992406004733	L13 binding site [polypeptide binding]; other site
992406004734	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
992406004735	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
992406004736	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
992406004737	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
992406004738	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
992406004739	anticodon binding site; other site
992406004740	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
992406004741	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
992406004742	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
992406004743	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
992406004744	active site
992406004745	dimer interface [polypeptide binding]; other site
992406004746	motif 1; other site
992406004747	motif 2; other site
992406004748	motif 3; other site
992406004749	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
992406004750	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
992406004751	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
992406004752	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
992406004753	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
992406004754	Glutamine amidotransferase class-I; Region: GATase; pfam00117
992406004755	glutamine binding [chemical binding]; other site
992406004756	catalytic triad [active]
992406004757	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
992406004758	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
992406004759	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
992406004760	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
992406004761	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
992406004762	active site
992406004763	ribulose/triose binding site [chemical binding]; other site
992406004764	phosphate binding site [ion binding]; other site
992406004765	substrate (anthranilate) binding pocket [chemical binding]; other site
992406004766	product (indole) binding pocket [chemical binding]; other site
992406004767	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
992406004768	active site
992406004769	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
992406004770	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
992406004771	pyridoxal 5'-phosphate binding site [chemical binding]; other site
992406004772	catalytic residue [active]
992406004773	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
992406004774	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
992406004775	substrate binding site [chemical binding]; other site
992406004776	active site
992406004777	catalytic residues [active]
992406004778	heterodimer interface [polypeptide binding]; other site
992406004779	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
992406004780	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
992406004781	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
992406004782	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
992406004783	Zn2+ binding site [ion binding]; other site
992406004784	Mg2+ binding site [ion binding]; other site
992406004785	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
992406004786	synthetase active site [active]
992406004787	NTP binding site [chemical binding]; other site
992406004788	metal binding site [ion binding]; metal-binding site
992406004789	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
992406004790	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
992406004791	DNA topoisomerase IV subunit A; Provisional; Region: PRK12758
992406004792	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
992406004793	CAP-like domain; other site
992406004794	active site
992406004795	primary dimer interface [polypeptide binding]; other site
992406004796	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
992406004797	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
992406004798	ATP binding site [chemical binding]; other site
992406004799	Mg2+ binding site [ion binding]; other site
992406004800	G-X-G motif; other site
992406004801	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
992406004802	anchoring element; other site
992406004803	dimer interface [polypeptide binding]; other site
992406004804	ATP binding site [chemical binding]; other site
992406004805	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
992406004806	active site
992406004807	putative metal-binding site [ion binding]; other site
992406004808	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
992406004809	Cell division protein ZapA; Region: ZapA; pfam05164
992406004810	phosphodiesterase; Provisional; Region: PRK12704
992406004811	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
992406004812	Zn2+ binding site [ion binding]; other site
992406004813	Mg2+ binding site [ion binding]; other site
992406004814	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
992406004815	putative rRNA binding site [nucleotide binding]; other site
992406004816	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
992406004817	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
992406004818	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
992406004819	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
992406004820	active site
992406004821	metal binding site [ion binding]; metal-binding site
992406004822	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406004823	YhhN-like protein; Region: YhhN; pfam07947
992406004824	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
992406004825	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
992406004826	Potassium binding sites [ion binding]; other site
992406004827	Cesium cation binding sites [ion binding]; other site
992406004828	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
992406004829	GTPase Era; Reviewed; Region: era; PRK00089
992406004830	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
992406004831	G1 box; other site
992406004832	GTP/Mg2+ binding site [chemical binding]; other site
992406004833	Switch I region; other site
992406004834	G2 box; other site
992406004835	Switch II region; other site
992406004836	G3 box; other site
992406004837	G4 box; other site
992406004838	G5 box; other site
992406004839	KH domain; Region: KH_2; pfam07650
992406004840	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
992406004841	PhoH-like protein; Region: PhoH; pfam02562
992406004842	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
992406004843	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
992406004844	DNA polymerase I; Provisional; Region: PRK05755
992406004845	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
992406004846	active site
992406004847	metal binding site 1 [ion binding]; metal-binding site
992406004848	putative 5' ssDNA interaction site; other site
992406004849	metal binding site 3; metal-binding site
992406004850	metal binding site 2 [ion binding]; metal-binding site
992406004851	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
992406004852	putative DNA binding site [nucleotide binding]; other site
992406004853	putative metal binding site [ion binding]; other site
992406004854	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
992406004855	active site
992406004856	catalytic site [active]
992406004857	substrate binding site [chemical binding]; other site
992406004858	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
992406004859	active site
992406004860	DNA binding site [nucleotide binding]
992406004861	catalytic site [active]
992406004862	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
992406004863	Part of AAA domain; Region: AAA_19; pfam13245
992406004864	Family description; Region: UvrD_C_2; pfam13538
992406004865	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
992406004866	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
992406004867	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
992406004868	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
992406004869	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
992406004870	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
992406004871	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
992406004872	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
992406004873	Probable Catalytic site; other site
992406004874	metal-binding site
992406004875	recombination protein RecR; Reviewed; Region: recR; PRK00076
992406004876	RecR protein; Region: RecR; pfam02132
992406004877	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
992406004878	putative active site [active]
992406004879	putative metal-binding site [ion binding]; other site
992406004880	tetramer interface [polypeptide binding]; other site
992406004881	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
992406004882	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
992406004883	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
992406004884	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
992406004885	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
992406004886	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
992406004887	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
992406004888	Zn binding site [ion binding]; other site
992406004889	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
992406004890	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
992406004891	Walker A/P-loop; other site
992406004892	ATP binding site [chemical binding]; other site
992406004893	Q-loop/lid; other site
992406004894	ABC transporter signature motif; other site
992406004895	Walker B; other site
992406004896	D-loop; other site
992406004897	H-loop/switch region; other site
992406004898	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
992406004899	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
992406004900	RNA binding surface [nucleotide binding]; other site
992406004901	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
992406004902	active site
992406004903	potential frameshift: common BLAST hit: gi|320117016|ref|YP_004187175.1| phospholipase D/transphosphatidylase
992406004904	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
992406004905	PLD-like domain; Region: PLDc_2; pfam13091
992406004906	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
992406004907	putative active site [active]
992406004908	catalytic site [active]
992406004909	asparagine synthetase B; Provisional; Region: asnB; PRK09431
992406004910	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
992406004911	active site
992406004912	dimer interface [polypeptide binding]; other site
992406004913	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
992406004914	Ligand Binding Site [chemical binding]; other site
992406004915	Molecular Tunnel; other site
992406004916	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
992406004917	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
992406004918	dimer interface [polypeptide binding]; other site
992406004919	anticodon binding site; other site
992406004920	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
992406004921	homodimer interface [polypeptide binding]; other site
992406004922	motif 1; other site
992406004923	active site
992406004924	motif 2; other site
992406004925	GAD domain; Region: GAD; pfam02938
992406004926	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
992406004927	active site
992406004928	motif 3; other site
992406004929	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
992406004930	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
992406004931	active site
992406004932	substrate binding site [chemical binding]; other site
992406004933	cosubstrate binding site; other site
992406004934	catalytic site [active]
992406004935	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
992406004936	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
992406004937	dimerization interface [polypeptide binding]; other site
992406004938	putative ATP binding site [chemical binding]; other site
992406004939	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
992406004940	active site
992406004941	catalytic triad [active]
992406004942	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
992406004943	FOG: PKD repeat [General function prediction only]; Region: COG3291
992406004944	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
992406004945	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
992406004946	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
992406004947	active site
992406004948	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
992406004949	active site
992406004950	dimer interface [polypeptide binding]; other site
992406004951	NlpE N-terminal domain; Region: NlpE; pfam04170
992406004952	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
992406004953	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
992406004954	ligand binding site [chemical binding]; other site
992406004955	flexible hinge region; other site
992406004956	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
992406004957	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
992406004958	S1 domain; Region: S1_2; pfam13509
992406004959	Protein of unknown function (DUF2693); Region: DUF2693; pfam10902
992406004960	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
992406004961	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
992406004962	non-specific DNA binding site [nucleotide binding]; other site
992406004963	salt bridge; other site
992406004964	sequence-specific DNA binding site [nucleotide binding]; other site
992406004965	AntA/AntB antirepressor; Region: AntA; cl01430
992406004966	Helix-turn-helix domain; Region: HTH_17; pfam12728
992406004967	Fic family protein [Function unknown]; Region: COG3177
992406004968	Fic/DOC family; Region: Fic; pfam02661
992406004969	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
992406004970	active site
992406004971	DNA binding site [nucleotide binding]
992406004972	Int/Topo IB signature motif; other site
992406004973	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
992406004974	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
992406004975	binding surface
992406004976	TPR motif; other site
992406004977	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
992406004978	binding surface
992406004979	TPR motif; other site
992406004980	Tetratricopeptide repeat; Region: TPR_12; pfam13424
992406004981	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
992406004982	binding surface
992406004983	TPR motif; other site
992406004984	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
992406004985	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
992406004986	Tetratricopeptide repeat; Region: TPR_16; pfam13432
992406004987	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
992406004988	TPR motif; other site
992406004989	binding surface
992406004990	phosphoglyceromutase; Provisional; Region: PRK05434
992406004991	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
992406004992	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
992406004993	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
992406004994	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
992406004995	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
992406004996	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
992406004997	active site
992406004998	metal binding site [ion binding]; metal-binding site
992406004999	nudix motif; other site
992406005000	GLPGLI family protein; Region: GLPGLI; TIGR01200
992406005001	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
992406005002	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
992406005003	oligomer interface [polypeptide binding]; other site
992406005004	active site
992406005005	metal binding site [ion binding]; metal-binding site
992406005006	Domain of unknown function (DUF4294); Region: DUF4294; pfam14127
992406005007	Protein of unknown function (DUF493); Region: DUF493; pfam04359
992406005008	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
992406005009	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
992406005010	Zn2+ binding site [ion binding]; other site
992406005011	Mg2+ binding site [ion binding]; other site
992406005012	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
992406005013	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
992406005014	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
992406005015	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
992406005016	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
992406005017	NAD(P) binding site [chemical binding]; other site
992406005018	catalytic residues [active]
992406005019	4Fe-4S binding domain; Region: Fer4; pfam00037
992406005020	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
992406005021	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
992406005022	catalytic residue [active]
992406005023	Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303
992406005024	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
992406005025	putative ligand binding site [chemical binding]; other site
992406005026	NAD binding site [chemical binding]; other site
992406005027	dimerization interface [polypeptide binding]; other site
992406005028	catalytic site [active]
992406005029	Mechanosensitive ion channel; Region: MS_channel; pfam00924
992406005030	GMP synthase; Reviewed; Region: guaA; PRK00074
992406005031	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
992406005032	AMP/PPi binding site [chemical binding]; other site
992406005033	candidate oxyanion hole; other site
992406005034	catalytic triad [active]
992406005035	potential glutamine specificity residues [chemical binding]; other site
992406005036	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
992406005037	ATP Binding subdomain [chemical binding]; other site
992406005038	Ligand Binding sites [chemical binding]; other site
992406005039	Dimerization subdomain; other site
992406005040	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
992406005041	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
992406005042	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
992406005043	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
992406005044	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
992406005045	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
992406005046	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
992406005047	putative active site [active]
992406005048	putative catalytic site [active]
992406005049	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
992406005050	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
992406005051	Ligand binding site; other site
992406005052	Putative Catalytic site; other site
992406005053	DXD motif; other site
992406005054	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
992406005055	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
992406005056	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
992406005057	trimer interface [polypeptide binding]; other site
992406005058	active site
992406005059	substrate binding site [chemical binding]; other site
992406005060	CoA binding site [chemical binding]; other site
992406005061	NlpC/P60 family; Region: NLPC_P60; pfam00877