-- dump date 20140620_035445 -- class Genbank::misc_feature -- table misc_feature_note -- id note 373994000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 373994000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 373994000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994000004 Walker A motif; other site 373994000005 ATP binding site [chemical binding]; other site 373994000006 Walker B motif; other site 373994000007 arginine finger; other site 373994000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 373994000009 DnaA box-binding interface [nucleotide binding]; other site 373994000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 373994000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 373994000012 putative DNA binding surface [nucleotide binding]; other site 373994000013 dimer interface [polypeptide binding]; other site 373994000014 beta-clamp/clamp loader binding surface; other site 373994000015 beta-clamp/translesion DNA polymerase binding surface; other site 373994000016 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994000017 GAF domain; Region: GAF; pfam01590 373994000018 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994000019 Phytochrome region; Region: PHY; pfam00360 373994000020 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994000021 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994000022 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994000023 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994000024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994000025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994000026 dimer interface [polypeptide binding]; other site 373994000027 phosphorylation site [posttranslational modification] 373994000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994000029 ATP binding site [chemical binding]; other site 373994000030 Mg2+ binding site [ion binding]; other site 373994000031 G-X-G motif; other site 373994000032 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 373994000033 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 373994000034 P loop; other site 373994000035 Nucleotide binding site [chemical binding]; other site 373994000036 DTAP/Switch II; other site 373994000037 Switch I; other site 373994000038 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 373994000039 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 373994000040 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 373994000041 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 373994000042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 373994000043 Homeodomain-like domain; Region: HTH_23; pfam13384 373994000044 Winged helix-turn helix; Region: HTH_29; pfam13551 373994000045 Homeodomain-like domain; Region: HTH_32; pfam13565 373994000046 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 373994000047 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994000048 ATP binding site [chemical binding]; other site 373994000049 putative Mg++ binding site [ion binding]; other site 373994000050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994000051 nucleotide binding region [chemical binding]; other site 373994000052 ATP-binding site [chemical binding]; other site 373994000053 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 373994000054 HRDC domain; Region: HRDC; pfam00570 373994000055 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 373994000056 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 373994000057 Walker A motif; other site 373994000058 ATP binding site [chemical binding]; other site 373994000059 Walker B motif; other site 373994000060 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 373994000061 tetramer interface [polypeptide binding]; other site 373994000062 dimer interface [polypeptide binding]; other site 373994000063 Protein of unknown function (DUF952); Region: DUF952; cl01393 373994000064 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 373994000065 active site 373994000066 catalytic residues [active] 373994000067 metal binding site [ion binding]; metal-binding site 373994000068 Exoribonuclease R [Transcription]; Region: VacB; COG0557 373994000069 RNB domain; Region: RNB; pfam00773 373994000070 ribosomal protein S18; Region: rps18; CHL00077 373994000071 ribosomal protein L33; Region: rpl33; CHL00104 373994000072 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 373994000073 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 373994000074 G1 box; other site 373994000075 putative GEF interaction site [polypeptide binding]; other site 373994000076 GTP/Mg2+ binding site [chemical binding]; other site 373994000077 Switch I region; other site 373994000078 G2 box; other site 373994000079 G3 box; other site 373994000080 Switch II region; other site 373994000081 G4 box; other site 373994000082 G5 box; other site 373994000083 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 373994000084 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 373994000085 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 373994000086 active site 373994000087 catalytic triad [active] 373994000088 oxyanion hole [active] 373994000089 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 373994000090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994000091 Coenzyme A binding pocket [chemical binding]; other site 373994000092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994000093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994000094 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994000095 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994000096 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 373994000097 Uncharacterized conserved protein [Function unknown]; Region: COG1262 373994000098 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 373994000099 Uncharacterized conserved protein [Function unknown]; Region: COG1262 373994000100 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 373994000101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 373994000102 MoxR-like ATPases [General function prediction only]; Region: COG0714 373994000103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 373994000104 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994000105 Uncharacterized conserved protein [Function unknown]; Region: COG1262 373994000106 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 373994000107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994000108 HAMP domain; Region: HAMP; pfam00672 373994000109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994000110 dimer interface [polypeptide binding]; other site 373994000111 phosphorylation site [posttranslational modification] 373994000112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994000113 ATP binding site [chemical binding]; other site 373994000114 Mg2+ binding site [ion binding]; other site 373994000115 G-X-G motif; other site 373994000116 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 373994000117 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 373994000118 Electron transfer DM13; Region: DM13; pfam10517 373994000119 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994000120 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 373994000121 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 373994000122 DXD motif; other site 373994000123 PilZ domain; Region: PilZ; pfam07238 373994000124 GTPase RsgA; Reviewed; Region: PRK01889 373994000125 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 373994000126 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 373994000127 GTPase/Zn-binding domain interface [polypeptide binding]; other site 373994000128 GTP/Mg2+ binding site [chemical binding]; other site 373994000129 G4 box; other site 373994000130 G5 box; other site 373994000131 G1 box; other site 373994000132 Switch I region; other site 373994000133 G2 box; other site 373994000134 G3 box; other site 373994000135 Switch II region; other site 373994000136 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 373994000137 active site 373994000138 Peptidase family M50; Region: Peptidase_M50; pfam02163 373994000139 putative substrate binding region [chemical binding]; other site 373994000140 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 373994000141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994000142 S-adenosylmethionine binding site [chemical binding]; other site 373994000143 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 373994000144 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 373994000145 active site residue [active] 373994000146 Peptidase family M48; Region: Peptidase_M48; cl12018 373994000147 Protein of unknown function (DUF938); Region: DUF938; pfam06080 373994000148 HNH endonuclease; Region: HNH_4; pfam13395 373994000149 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 373994000150 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 373994000151 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 373994000152 homodimer interface [polypeptide binding]; other site 373994000153 metal binding site [ion binding]; metal-binding site 373994000154 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 373994000155 homodimer interface [polypeptide binding]; other site 373994000156 active site 373994000157 putative chemical substrate binding site [chemical binding]; other site 373994000158 metal binding site [ion binding]; metal-binding site 373994000159 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 373994000160 TIGR02588 family protein; Region: TIGR02588 373994000161 Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622 373994000162 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994000163 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994000164 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994000165 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 373994000166 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 373994000167 putative catalytic cysteine [active] 373994000168 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 373994000169 chorismate binding enzyme; Region: Chorismate_bind; cl10555 373994000170 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 373994000171 UbiA prenyltransferase family; Region: UbiA; pfam01040 373994000172 O-succinylbenzoate synthase; Provisional; Region: PRK02714 373994000173 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 373994000174 active site 373994000175 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 373994000176 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 373994000177 acyl-activating enzyme (AAE) consensus motif; other site 373994000178 putative AMP binding site [chemical binding]; other site 373994000179 putative active site [active] 373994000180 putative CoA binding site [chemical binding]; other site 373994000181 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 373994000182 active site 373994000183 Phosphotransferase enzyme family; Region: APH; pfam01636 373994000184 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 373994000185 substrate binding site [chemical binding]; other site 373994000186 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 373994000187 active site 373994000188 DNA binding site [nucleotide binding] 373994000189 Transmembrane proteins 14C; Region: Tmemb_14; cl02346 373994000190 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 373994000191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994000192 Walker A motif; other site 373994000193 ATP binding site [chemical binding]; other site 373994000194 Walker B motif; other site 373994000195 arginine finger; other site 373994000196 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 373994000197 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 373994000198 AAA ATPase domain; Region: AAA_16; pfam13191 373994000199 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 373994000200 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 373994000201 Sulfate transporter family; Region: Sulfate_transp; pfam00916 373994000202 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 373994000203 Protein of unknown function DUF262; Region: DUF262; pfam03235 373994000204 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994000205 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994000206 active site 373994000207 ATP binding site [chemical binding]; other site 373994000208 substrate binding site [chemical binding]; other site 373994000209 activation loop (A-loop); other site 373994000210 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 373994000211 C factor cell-cell signaling protein; Provisional; Region: PRK09009 373994000212 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 373994000213 NADP binding site [chemical binding]; other site 373994000214 homodimer interface [polypeptide binding]; other site 373994000215 active site 373994000216 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 373994000217 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 373994000218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994000219 dimerization interface [polypeptide binding]; other site 373994000220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994000221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994000222 dimer interface [polypeptide binding]; other site 373994000223 phosphorylation site [posttranslational modification] 373994000224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994000225 ATP binding site [chemical binding]; other site 373994000226 Mg2+ binding site [ion binding]; other site 373994000227 G-X-G motif; other site 373994000228 PAS fold; Region: PAS; pfam00989 373994000229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994000230 putative active site [active] 373994000231 heme pocket [chemical binding]; other site 373994000232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994000233 ATP binding site [chemical binding]; other site 373994000234 Mg2+ binding site [ion binding]; other site 373994000235 G-X-G motif; other site 373994000236 Predicted transcriptional regulator [Transcription]; Region: COG2345 373994000237 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 373994000238 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 373994000239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373994000240 catalytic residue [active] 373994000241 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994000242 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994000243 active site 373994000244 ATP binding site [chemical binding]; other site 373994000245 substrate binding site [chemical binding]; other site 373994000246 activation loop (A-loop); other site 373994000247 RDD family; Region: RDD; pfam06271 373994000248 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 373994000249 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994000250 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373994000251 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994000252 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994000253 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373994000254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994000255 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 373994000256 ATP binding site [chemical binding]; other site 373994000257 putative Mg++ binding site [ion binding]; other site 373994000258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994000259 nucleotide binding region [chemical binding]; other site 373994000260 ATP-binding site [chemical binding]; other site 373994000261 choline dehydrogenase; Validated; Region: PRK02106 373994000262 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373994000263 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 373994000264 phosphodiesterase YaeI; Provisional; Region: PRK11340 373994000265 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 373994000266 putative active site [active] 373994000267 putative metal binding site [ion binding]; other site 373994000268 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 373994000269 phosphodiesterase YaeI; Provisional; Region: PRK11340 373994000270 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 373994000271 putative active site [active] 373994000272 putative metal binding site [ion binding]; other site 373994000273 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 373994000274 Uncharacterized conserved protein [Function unknown]; Region: COG1434 373994000275 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 373994000276 putative active site [active] 373994000277 Uncharacterized small conserved protein [Function unknown]; Region: COG5626 373994000278 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 373994000279 Domain of unknown function DUF20; Region: UPF0118; pfam01594 373994000280 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 373994000281 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 373994000282 putative acyl-acceptor binding pocket; other site 373994000283 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 373994000284 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 373994000285 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 373994000286 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 373994000287 dimer interface [polypeptide binding]; other site 373994000288 active site 373994000289 CoA binding pocket [chemical binding]; other site 373994000290 putative phosphate acyltransferase; Provisional; Region: PRK05331 373994000291 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 373994000292 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 373994000293 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 373994000294 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 373994000295 Uncharacterized conserved protein [Function unknown]; Region: COG1432 373994000296 LabA_like proteins; Region: LabA; cd10911 373994000297 putative metal binding site [ion binding]; other site 373994000298 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 373994000299 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 373994000300 active site 373994000301 HIGH motif; other site 373994000302 KMSKS motif; other site 373994000303 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 373994000304 tRNA binding surface [nucleotide binding]; other site 373994000305 anticodon binding site; other site 373994000306 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373994000307 FtsX-like permease family; Region: FtsX; pfam02687 373994000308 Bacterial SH3 domain; Region: SH3_3; pfam08239 373994000309 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 373994000310 multifunctional aminopeptidase A; Provisional; Region: PRK00913 373994000311 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 373994000312 interface (dimer of trimers) [polypeptide binding]; other site 373994000313 Substrate-binding/catalytic site; other site 373994000314 Zn-binding sites [ion binding]; other site 373994000315 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 373994000316 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 373994000317 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 373994000318 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 373994000319 MutS domain III; Region: MutS_III; pfam05192 373994000320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994000321 Walker A/P-loop; other site 373994000322 ATP binding site [chemical binding]; other site 373994000323 Q-loop/lid; other site 373994000324 ABC transporter signature motif; other site 373994000325 Walker B; other site 373994000326 D-loop; other site 373994000327 H-loop/switch region; other site 373994000328 Smr domain; Region: Smr; pfam01713 373994000329 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 373994000330 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 373994000331 active site 373994000332 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 373994000333 catalytic residues [active] 373994000334 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 373994000335 Ycf35; Provisional; Region: ycf35; CHL00193 373994000336 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 373994000337 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 373994000338 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 373994000339 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 373994000340 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 373994000341 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 373994000342 Walker A motif; other site 373994000343 ATP binding site [chemical binding]; other site 373994000344 Walker B motif; other site 373994000345 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 373994000346 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 373994000347 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 373994000348 Walker A motif; other site 373994000349 ATP binding site [chemical binding]; other site 373994000350 Walker B motif; other site 373994000351 GrpE; Region: GrpE; pfam01025 373994000352 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 373994000353 dimer interface [polypeptide binding]; other site 373994000354 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 373994000355 molecular chaperone DnaK; Provisional; Region: PRK13411 373994000356 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 373994000357 nucleotide binding site [chemical binding]; other site 373994000358 NEF interaction site [polypeptide binding]; other site 373994000359 SBD interface [polypeptide binding]; other site 373994000360 chaperone protein DnaJ; Provisional; Region: PRK14293 373994000361 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373994000362 HSP70 interaction site [polypeptide binding]; other site 373994000363 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 373994000364 Zn binding sites [ion binding]; other site 373994000365 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 373994000366 dimer interface [polypeptide binding]; other site 373994000367 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 373994000368 CPxP motif; other site 373994000369 GTPase RsgA; Reviewed; Region: PRK12289 373994000370 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 373994000371 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 373994000372 GTPase/Zn-binding domain interface [polypeptide binding]; other site 373994000373 GTP/Mg2+ binding site [chemical binding]; other site 373994000374 G4 box; other site 373994000375 G5 box; other site 373994000376 G1 box; other site 373994000377 Switch I region; other site 373994000378 G2 box; other site 373994000379 G3 box; other site 373994000380 Switch II region; other site 373994000381 Uncharacterized conserved protein [Function unknown]; Region: COG1543 373994000382 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 373994000383 active site 373994000384 substrate binding site [chemical binding]; other site 373994000385 catalytic site [active] 373994000386 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 373994000387 hypothetical protein; Provisional; Region: PRK06849 373994000388 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 373994000389 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 373994000390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994000391 S-adenosylmethionine binding site [chemical binding]; other site 373994000392 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 373994000393 active site 373994000394 NAD binding site [chemical binding]; other site 373994000395 metal binding site [ion binding]; metal-binding site 373994000396 apocytochrome f; Reviewed; Region: PRK02693 373994000397 cytochrome f; Region: petA; CHL00037 373994000398 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 373994000399 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 373994000400 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 373994000401 cytochrome b subunit interaction site [polypeptide binding]; other site 373994000402 [2Fe-2S] cluster binding site [ion binding]; other site 373994000403 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 373994000404 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 373994000405 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 373994000406 dimer interface [polypeptide binding]; other site 373994000407 putative tRNA-binding site [nucleotide binding]; other site 373994000408 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 373994000409 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 373994000410 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994000411 AAA ATPase domain; Region: AAA_16; pfam13191 373994000412 Iguana/Dzip1-like DAZ-interacting protein N-terminal; Region: Dzip-like_N; pfam13815 373994000413 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994000414 structural tetrad; other site 373994000415 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994000416 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994000417 structural tetrad; other site 373994000418 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 373994000419 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 373994000420 N-acetyl-D-glucosamine binding site [chemical binding]; other site 373994000421 catalytic residue [active] 373994000422 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 373994000423 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 373994000424 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 373994000425 FOG: CBS domain [General function prediction only]; Region: COG0517 373994000426 FOG: CBS domain [General function prediction only]; Region: COG0517 373994000427 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 373994000428 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373994000429 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373994000430 metal binding site [ion binding]; metal-binding site 373994000431 active site 373994000432 I-site; other site 373994000433 hypothetical protein; Validated; Region: PRK00110 373994000434 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373994000435 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 373994000436 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 373994000437 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 373994000438 HEAT repeats; Region: HEAT_2; pfam13646 373994000439 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 373994000440 protein binding surface [polypeptide binding]; other site 373994000441 HEAT repeats; Region: HEAT_2; pfam13646 373994000442 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 373994000443 HEAT repeats; Region: HEAT_2; pfam13646 373994000444 protein binding surface [polypeptide binding]; other site 373994000445 HEAT repeats; Region: HEAT_2; pfam13646 373994000446 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 373994000447 HEAT repeats; Region: HEAT_2; pfam13646 373994000448 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 373994000449 Walker A motif; other site 373994000450 ATP binding site [chemical binding]; other site 373994000451 Walker B motif; other site 373994000452 HEAT repeats; Region: HEAT_2; pfam13646 373994000453 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 373994000454 protein binding surface [polypeptide binding]; other site 373994000455 HEAT repeats; Region: HEAT_2; pfam13646 373994000456 HEAT repeats; Region: HEAT_2; pfam13646 373994000457 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 373994000458 protein binding surface [polypeptide binding]; other site 373994000459 HEAT repeats; Region: HEAT_2; pfam13646 373994000460 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 373994000461 HEAT repeats; Region: HEAT_2; pfam13646 373994000462 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 373994000463 NACHT domain; Region: NACHT; pfam05729 373994000464 HEAT repeats; Region: HEAT_2; pfam13646 373994000465 HEAT repeats; Region: HEAT_2; pfam13646 373994000466 HEAT repeat; Region: HEAT; pfam02985 373994000467 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 373994000468 HEAT repeats; Region: HEAT_2; pfam13646 373994000469 protein binding surface [polypeptide binding]; other site 373994000470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 373994000471 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 373994000472 HEAT repeat; Region: HEAT; pfam02985 373994000473 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 373994000474 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 373994000475 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 373994000476 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 373994000477 protein binding surface [polypeptide binding]; other site 373994000478 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 373994000479 protein binding surface [polypeptide binding]; other site 373994000480 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 373994000481 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 373994000482 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 373994000483 Response regulator receiver domain; Region: Response_reg; pfam00072 373994000484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994000485 active site 373994000486 phosphorylation site [posttranslational modification] 373994000487 intermolecular recognition site; other site 373994000488 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994000489 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 373994000490 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 373994000491 catalytic residue [active] 373994000492 putative FPP diphosphate binding site; other site 373994000493 putative FPP binding hydrophobic cleft; other site 373994000494 dimer interface [polypeptide binding]; other site 373994000495 putative IPP diphosphate binding site; other site 373994000496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994000497 TPR motif; other site 373994000498 binding surface 373994000499 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994000500 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994000501 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994000502 acetyl-CoA synthetase; Provisional; Region: PRK00174 373994000503 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 373994000504 active site 373994000505 CoA binding site [chemical binding]; other site 373994000506 acyl-activating enzyme (AAE) consensus motif; other site 373994000507 AMP binding site [chemical binding]; other site 373994000508 acetate binding site [chemical binding]; other site 373994000509 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 373994000510 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 373994000511 classical (c) SDRs; Region: SDR_c; cd05233 373994000512 NAD(P) binding site [chemical binding]; other site 373994000513 active site 373994000514 TPR repeat; Region: TPR_11; pfam13414 373994000515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994000516 binding surface 373994000517 TPR motif; other site 373994000518 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994000519 binding surface 373994000520 TPR repeat; Region: TPR_11; pfam13414 373994000521 TPR motif; other site 373994000522 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 373994000523 MarR family; Region: MarR; pfam01047 373994000524 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 373994000525 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 373994000526 ATP adenylyltransferase; Region: ATP_transf; pfam09830 373994000527 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 373994000528 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 373994000529 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 373994000530 G-X-X-G motif; other site 373994000531 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 373994000532 RxxxH motif; other site 373994000533 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 373994000534 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 373994000535 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 373994000536 Bacterial PH domain; Region: DUF304; pfam03703 373994000537 ribonuclease P; Reviewed; Region: rnpA; PRK03031 373994000538 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 373994000539 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 373994000540 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 373994000541 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 373994000542 ligand binding site [chemical binding]; other site 373994000543 homodimer interface [polypeptide binding]; other site 373994000544 NAD(P) binding site [chemical binding]; other site 373994000545 trimer interface B [polypeptide binding]; other site 373994000546 trimer interface A [polypeptide binding]; other site 373994000547 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 373994000548 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 373994000549 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 373994000550 TPR repeat; Region: TPR_11; pfam13414 373994000551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994000552 binding surface 373994000553 TPR motif; other site 373994000554 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994000555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994000556 binding surface 373994000557 TPR motif; other site 373994000558 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994000559 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994000560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994000561 binding surface 373994000562 TPR motif; other site 373994000563 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994000564 Tetratricopeptide repeat; Region: TPR_10; pfam13374 373994000565 PetN; Region: PetN; pfam03742 373994000566 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 373994000567 active site 373994000568 catalytic site [active] 373994000569 substrate binding site [chemical binding]; other site 373994000570 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 373994000571 Phosphotransferase enzyme family; Region: APH; pfam01636 373994000572 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 373994000573 active site 373994000574 ATP binding site [chemical binding]; other site 373994000575 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 373994000576 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 373994000577 homodimer interface [polypeptide binding]; other site 373994000578 substrate-cofactor binding pocket; other site 373994000579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994000580 catalytic residue [active] 373994000581 FtsH Extracellular; Region: FtsH_ext; pfam06480 373994000582 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 373994000583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994000584 Walker A motif; other site 373994000585 ATP binding site [chemical binding]; other site 373994000586 Walker B motif; other site 373994000587 arginine finger; other site 373994000588 Peptidase family M41; Region: Peptidase_M41; pfam01434 373994000589 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994000590 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994000591 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994000592 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 373994000593 NADH(P)-binding; Region: NAD_binding_10; pfam13460 373994000594 NAD(P) binding site [chemical binding]; other site 373994000595 putative active site [active] 373994000596 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 373994000597 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 373994000598 trmE is a tRNA modification GTPase; Region: trmE; cd04164 373994000599 G1 box; other site 373994000600 GTP/Mg2+ binding site [chemical binding]; other site 373994000601 Switch I region; other site 373994000602 G2 box; other site 373994000603 Switch II region; other site 373994000604 G3 box; other site 373994000605 G4 box; other site 373994000606 G5 box; other site 373994000607 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 373994000608 S-layer homology domain; Region: SLH; pfam00395 373994000609 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 373994000610 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 373994000611 active site 373994000612 catalytic triad [active] 373994000613 oxyanion hole [active] 373994000614 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 373994000615 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 373994000616 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 373994000617 M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343 373994000618 FOG: CBS domain [General function prediction only]; Region: COG0517 373994000619 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 373994000620 HEAT repeats; Region: HEAT_2; pfam13646 373994000621 HEAT repeats; Region: HEAT_2; pfam13646 373994000622 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 373994000623 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 373994000624 dimerization interface [polypeptide binding]; other site 373994000625 domain crossover interface; other site 373994000626 redox-dependent activation switch; other site 373994000627 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 373994000628 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994000629 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 373994000630 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 373994000631 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 373994000632 Phosphotransferase enzyme family; Region: APH; pfam01636 373994000633 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 373994000634 active site 373994000635 ATP binding site [chemical binding]; other site 373994000636 WYL domain; Region: WYL; pfam13280 373994000637 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 373994000638 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 373994000639 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 373994000640 CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174 373994000641 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709 373994000642 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711 373994000643 CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159 373994000644 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 373994000645 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 373994000646 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 373994000647 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 373994000648 Response regulator receiver domain; Region: Response_reg; pfam00072 373994000649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994000650 active site 373994000651 phosphorylation site [posttranslational modification] 373994000652 intermolecular recognition site; other site 373994000653 dimerization interface [polypeptide binding]; other site 373994000654 Response regulator receiver domain; Region: Response_reg; pfam00072 373994000655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994000656 active site 373994000657 phosphorylation site [posttranslational modification] 373994000658 intermolecular recognition site; other site 373994000659 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994000660 dimerization interface [polypeptide binding]; other site 373994000661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994000662 dimer interface [polypeptide binding]; other site 373994000663 phosphorylation site [posttranslational modification] 373994000664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994000665 ATP binding site [chemical binding]; other site 373994000666 Mg2+ binding site [ion binding]; other site 373994000667 G-X-G motif; other site 373994000668 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994000669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994000670 active site 373994000671 phosphorylation site [posttranslational modification] 373994000672 intermolecular recognition site; other site 373994000673 dimerization interface [polypeptide binding]; other site 373994000674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994000675 dimer interface [polypeptide binding]; other site 373994000676 phosphorylation site [posttranslational modification] 373994000677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994000678 ATP binding site [chemical binding]; other site 373994000679 Mg2+ binding site [ion binding]; other site 373994000680 G-X-G motif; other site 373994000681 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994000682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994000683 active site 373994000684 phosphorylation site [posttranslational modification] 373994000685 intermolecular recognition site; other site 373994000686 dimerization interface [polypeptide binding]; other site 373994000687 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994000688 DNA binding residues [nucleotide binding] 373994000689 dimerization interface [polypeptide binding]; other site 373994000690 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 373994000691 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 373994000692 NAD(P) binding site [chemical binding]; other site 373994000693 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 373994000694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994000695 putative ADP-binding pocket [chemical binding]; other site 373994000696 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373994000697 Chain length determinant protein; Region: Wzz; cl15801 373994000698 Chain length determinant protein; Region: Wzz; cl15801 373994000699 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 373994000700 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994000701 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 373994000702 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 373994000703 inhibitor-cofactor binding pocket; inhibition site 373994000704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994000705 catalytic residue [active] 373994000706 FemAB family; Region: FemAB; pfam02388 373994000707 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 373994000708 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 373994000709 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 373994000710 Bacterial sugar transferase; Region: Bac_transf; pfam02397 373994000711 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994000712 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 373994000713 putative ADP-binding pocket [chemical binding]; other site 373994000714 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373994000715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994000716 NAD(P) binding site [chemical binding]; other site 373994000717 active site 373994000718 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 373994000719 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 373994000720 active site 373994000721 dimer interface [polypeptide binding]; other site 373994000722 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 373994000723 Ligand Binding Site [chemical binding]; other site 373994000724 Molecular Tunnel; other site 373994000725 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994000726 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 373994000727 putative ADP-binding pocket [chemical binding]; other site 373994000728 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994000729 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 373994000730 putative ADP-binding pocket [chemical binding]; other site 373994000731 O-Antigen ligase; Region: Wzy_C; pfam04932 373994000732 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994000733 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 373994000734 putative ADP-binding pocket [chemical binding]; other site 373994000735 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 373994000736 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 373994000737 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 373994000738 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 373994000739 NAD(P) binding site [chemical binding]; other site 373994000740 homodimer interface [polypeptide binding]; other site 373994000741 substrate binding site [chemical binding]; other site 373994000742 active site 373994000743 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 373994000744 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 373994000745 putative valine binding site [chemical binding]; other site 373994000746 dimer interface [polypeptide binding]; other site 373994000747 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 373994000748 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 373994000749 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 373994000750 catalytic residues [active] 373994000751 Clp protease; Region: CLP_protease; pfam00574 373994000752 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 373994000753 oligomer interface [polypeptide binding]; other site 373994000754 active site residues [active] 373994000755 CheB methylesterase; Region: CheB_methylest; pfam01339 373994000756 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 373994000757 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 373994000758 PAS domain; Region: PAS_10; pfam13596 373994000759 PAS fold; Region: PAS_4; pfam08448 373994000760 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994000761 putative active site [active] 373994000762 heme pocket [chemical binding]; other site 373994000763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994000764 dimer interface [polypeptide binding]; other site 373994000765 phosphorylation site [posttranslational modification] 373994000766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994000767 ATP binding site [chemical binding]; other site 373994000768 Mg2+ binding site [ion binding]; other site 373994000769 G-X-G motif; other site 373994000770 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994000771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994000772 active site 373994000773 phosphorylation site [posttranslational modification] 373994000774 intermolecular recognition site; other site 373994000775 dimerization interface [polypeptide binding]; other site 373994000776 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 373994000777 CheB methylesterase; Region: CheB_methylest; pfam01339 373994000778 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 373994000779 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 373994000780 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 373994000781 PAS domain; Region: PAS_10; pfam13596 373994000782 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994000783 putative active site [active] 373994000784 heme pocket [chemical binding]; other site 373994000785 PAS fold; Region: PAS_4; pfam08448 373994000786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994000787 putative active site [active] 373994000788 heme pocket [chemical binding]; other site 373994000789 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994000790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994000791 dimer interface [polypeptide binding]; other site 373994000792 phosphorylation site [posttranslational modification] 373994000793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994000794 ATP binding site [chemical binding]; other site 373994000795 Mg2+ binding site [ion binding]; other site 373994000796 G-X-G motif; other site 373994000797 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994000798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994000799 active site 373994000800 phosphorylation site [posttranslational modification] 373994000801 intermolecular recognition site; other site 373994000802 dimerization interface [polypeptide binding]; other site 373994000803 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 373994000804 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 373994000805 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 373994000806 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 373994000807 UbiA prenyltransferase family; Region: UbiA; pfam01040 373994000808 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 373994000809 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 373994000810 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 373994000811 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 373994000812 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 373994000813 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 373994000814 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 373994000815 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 373994000816 Subunit I/III interface [polypeptide binding]; other site 373994000817 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994000818 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994000819 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994000820 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 373994000821 GIY-YIG motif/motif A; other site 373994000822 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 373994000823 active site 373994000824 8-oxo-dGMP binding site [chemical binding]; other site 373994000825 nudix motif; other site 373994000826 metal binding site [ion binding]; metal-binding site 373994000827 adaptive-response sensory kinase; Validated; Region: PRK09303 373994000828 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 373994000829 tetramer interface [polypeptide binding]; other site 373994000830 dimer interface [polypeptide binding]; other site 373994000831 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994000832 dimer interface [polypeptide binding]; other site 373994000833 phosphorylation site [posttranslational modification] 373994000834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994000835 ATP binding site [chemical binding]; other site 373994000836 Mg2+ binding site [ion binding]; other site 373994000837 G-X-G motif; other site 373994000838 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994000839 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994000840 active site 373994000841 ATP binding site [chemical binding]; other site 373994000842 substrate binding site [chemical binding]; other site 373994000843 activation loop (A-loop); other site 373994000844 YARHG domain; Region: YARHG; pfam13308 373994000845 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994000846 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994000847 active site 373994000848 ATP binding site [chemical binding]; other site 373994000849 substrate binding site [chemical binding]; other site 373994000850 activation loop (A-loop); other site 373994000851 AAA ATPase domain; Region: AAA_16; pfam13191 373994000852 AAA ATPase domain; Region: AAA_16; pfam13191 373994000853 AAA domain; Region: AAA_22; pfam13401 373994000854 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 373994000855 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 373994000856 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 373994000857 Catalytic site [active] 373994000858 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 373994000859 Dehydratase family; Region: ILVD_EDD; cl00340 373994000860 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 373994000861 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 373994000862 Transglycosylase; Region: Transgly; pfam00912 373994000863 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 373994000864 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 373994000865 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 373994000866 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 373994000867 active site 373994000868 HIGH motif; other site 373994000869 dimer interface [polypeptide binding]; other site 373994000870 KMSKS motif; other site 373994000871 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 373994000872 active site 373994000873 dimer interface [polypeptide binding]; other site 373994000874 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 373994000875 putative active site [active] 373994000876 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 373994000877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 373994000878 putative active site [active] 373994000879 heme pocket [chemical binding]; other site 373994000880 GAF domain; Region: GAF; pfam01590 373994000881 Phytochrome region; Region: PHY; pfam00360 373994000882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994000883 dimer interface [polypeptide binding]; other site 373994000884 phosphorylation site [posttranslational modification] 373994000885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994000886 ATP binding site [chemical binding]; other site 373994000887 Mg2+ binding site [ion binding]; other site 373994000888 G-X-G motif; other site 373994000889 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 373994000890 Amidase; Region: Amidase; pfam01425 373994000891 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 373994000892 ketol-acid reductoisomerase; Provisional; Region: PRK05479 373994000893 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 373994000894 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 373994000895 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373994000896 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373994000897 active site 373994000898 catalytic tetrad [active] 373994000899 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 373994000900 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 373994000901 NADPH bind site [chemical binding]; other site 373994000902 putative FMN binding site [chemical binding]; other site 373994000903 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 373994000904 putative FMN binding site [chemical binding]; other site 373994000905 NADPH bind site [chemical binding]; other site 373994000906 Uncharacterized conserved protein [Function unknown]; Region: COG1432 373994000907 LabA_like proteins; Region: LabA; cd10911 373994000908 putative metal binding site [ion binding]; other site 373994000909 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 373994000910 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 373994000911 putative active site [active] 373994000912 putative metal binding site [ion binding]; other site 373994000913 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994000914 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994000915 active site 373994000916 ATP binding site [chemical binding]; other site 373994000917 substrate binding site [chemical binding]; other site 373994000918 activation loop (A-loop); other site 373994000919 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994000920 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994000921 active site 373994000922 ATP binding site [chemical binding]; other site 373994000923 substrate binding site [chemical binding]; other site 373994000924 activation loop (A-loop); other site 373994000925 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994000926 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994000927 active site 373994000928 ATP binding site [chemical binding]; other site 373994000929 substrate binding site [chemical binding]; other site 373994000930 activation loop (A-loop); other site 373994000931 glycogen synthase; Provisional; Region: glgA; PRK00654 373994000932 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 373994000933 ADP-binding pocket [chemical binding]; other site 373994000934 homodimer interface [polypeptide binding]; other site 373994000935 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 373994000936 HEAT repeats; Region: HEAT_2; pfam13646 373994000937 HEAT repeats; Region: HEAT_2; pfam13646 373994000938 HEAT repeats; Region: HEAT_2; pfam13646 373994000939 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 373994000940 Coenzyme A binding pocket [chemical binding]; other site 373994000941 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 373994000942 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 373994000943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994000944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994000945 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 373994000946 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 373994000947 nucleotide binding site [chemical binding]; other site 373994000948 putative NEF/HSP70 interaction site [polypeptide binding]; other site 373994000949 SBD interface [polypeptide binding]; other site 373994000950 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 373994000951 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 373994000952 Walker A/P-loop; other site 373994000953 ATP binding site [chemical binding]; other site 373994000954 Q-loop/lid; other site 373994000955 ABC transporter signature motif; other site 373994000956 Walker B; other site 373994000957 D-loop; other site 373994000958 H-loop/switch region; other site 373994000959 TOBE-like domain; Region: TOBE_3; pfam12857 373994000960 CARDB; Region: CARDB; pfam07705 373994000961 Uncharacterized conserved protein [Function unknown]; Region: COG3339 373994000962 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 373994000963 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373994000964 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994000965 DNA polymerase III subunit delta'; Validated; Region: PRK07399 373994000966 AAA ATPase domain; Region: AAA_16; pfam13191 373994000967 Walker A motif; other site 373994000968 ATP binding site [chemical binding]; other site 373994000969 Walker B motif; other site 373994000970 arginine finger; other site 373994000971 thymidylate kinase; Validated; Region: tmk; PRK00698 373994000972 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 373994000973 TMP-binding site; other site 373994000974 ATP-binding site [chemical binding]; other site 373994000975 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 373994000976 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 373994000977 catalytic residues [active] 373994000978 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373994000979 dimerization interface [polypeptide binding]; other site 373994000980 putative DNA binding site [nucleotide binding]; other site 373994000981 putative Zn2+ binding site [ion binding]; other site 373994000982 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994000983 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994000984 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 373994000985 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 373994000986 metal ion-dependent adhesion site (MIDAS); other site 373994000987 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 373994000988 metal ion-dependent adhesion site (MIDAS); other site 373994000989 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 373994000990 metal ion-dependent adhesion site (MIDAS); other site 373994000991 Predicted transcriptional regulators [Transcription]; Region: COG1733 373994000992 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 373994000993 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 373994000994 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 373994000995 2TM domain; Region: 2TM; pfam13239 373994000996 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 373994000997 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 373994000998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994000999 motif II; other site 373994001000 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 373994001001 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 373994001002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 373994001003 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 373994001004 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 373994001005 active site 373994001006 intersubunit interface [polypeptide binding]; other site 373994001007 catalytic residue [active] 373994001008 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994001009 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994001010 structural tetrad; other site 373994001011 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 373994001012 PhoH-like protein; Region: PhoH; pfam02562 373994001013 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 373994001014 KH domain; Region: KH_4; pfam13083 373994001015 G-X-X-G motif; other site 373994001016 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 373994001017 signal recognition particle protein; Provisional; Region: PRK10867 373994001018 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 373994001019 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 373994001020 GTP binding site [chemical binding]; other site 373994001021 Signal peptide binding domain; Region: SRP_SPB; pfam02978 373994001022 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994001023 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994001024 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994001025 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994001026 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994001027 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994001028 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 373994001029 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 373994001030 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 373994001031 active site 373994001032 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 373994001033 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994001034 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994001035 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 373994001036 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 373994001037 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 373994001038 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 373994001039 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 373994001040 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 373994001041 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 373994001042 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 373994001043 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 373994001044 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994001045 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994001046 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994001047 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994001048 ligand binding site [chemical binding]; other site 373994001049 flexible hinge region; other site 373994001050 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 373994001051 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 373994001052 putative active site [active] 373994001053 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994001054 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 373994001055 Walker A/P-loop; other site 373994001056 ATP binding site [chemical binding]; other site 373994001057 Q-loop/lid; other site 373994001058 ABC transporter signature motif; other site 373994001059 Walker B; other site 373994001060 D-loop; other site 373994001061 H-loop/switch region; other site 373994001062 M28 Zn-Peptidases; Region: M28_like_3; cd05644 373994001063 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 373994001064 active site 373994001065 metal binding site [ion binding]; metal-binding site 373994001066 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 373994001067 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 373994001068 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373994001069 catalytic residue [active] 373994001070 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 373994001071 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 373994001072 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994001073 active site 373994001074 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 373994001075 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994001076 Methyltransferase domain; Region: Methyltransf_12; pfam08242 373994001077 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 373994001078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994001079 TPR motif; other site 373994001080 binding surface 373994001081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994001082 binding surface 373994001083 TPR repeat; Region: TPR_11; pfam13414 373994001084 TPR motif; other site 373994001085 TPR repeat; Region: TPR_11; pfam13414 373994001086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994001087 binding surface 373994001088 TPR motif; other site 373994001089 TPR repeat; Region: TPR_11; pfam13414 373994001090 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994001091 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 373994001092 active site 373994001093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994001094 binding surface 373994001095 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373994001096 TPR motif; other site 373994001097 TPR repeat; Region: TPR_11; pfam13414 373994001098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994001099 binding surface 373994001100 TPR motif; other site 373994001101 TPR repeat; Region: TPR_11; pfam13414 373994001102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994001103 binding surface 373994001104 TPR motif; other site 373994001105 TPR repeat; Region: TPR_11; pfam13414 373994001106 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 373994001107 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 373994001108 trimer interface [polypeptide binding]; other site 373994001109 active site 373994001110 substrate binding site [chemical binding]; other site 373994001111 CoA binding site [chemical binding]; other site 373994001112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994001113 binding surface 373994001114 TPR repeat; Region: TPR_11; pfam13414 373994001115 TPR motif; other site 373994001116 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373994001117 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994001118 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 373994001119 active site 373994001120 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 373994001121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994001122 binding surface 373994001123 TPR motif; other site 373994001124 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373994001125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994001126 binding surface 373994001127 TPR motif; other site 373994001128 TPR repeat; Region: TPR_11; pfam13414 373994001129 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994001130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994001131 binding surface 373994001132 TPR motif; other site 373994001133 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994001134 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 373994001135 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 373994001136 hypothetical protein; Provisional; Region: PRK04140 373994001137 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 373994001138 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994001139 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994001140 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994001141 ligand binding site [chemical binding]; other site 373994001142 flexible hinge region; other site 373994001143 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 373994001144 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 373994001145 putative active site [active] 373994001146 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994001147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994001148 Walker A/P-loop; other site 373994001149 ATP binding site [chemical binding]; other site 373994001150 Q-loop/lid; other site 373994001151 ABC transporter signature motif; other site 373994001152 Walker B; other site 373994001153 D-loop; other site 373994001154 H-loop/switch region; other site 373994001155 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 373994001156 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 373994001157 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994001158 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994001159 ligand binding site [chemical binding]; other site 373994001160 flexible hinge region; other site 373994001161 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 373994001162 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 373994001163 putative active site [active] 373994001164 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994001165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994001166 Walker A/P-loop; other site 373994001167 ATP binding site [chemical binding]; other site 373994001168 Q-loop/lid; other site 373994001169 ABC transporter signature motif; other site 373994001170 Walker B; other site 373994001171 D-loop; other site 373994001172 H-loop/switch region; other site 373994001173 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 373994001174 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 373994001175 Protein of unknown function, DUF608; Region: DUF608; pfam04685 373994001176 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 373994001177 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 373994001178 NAD binding site [chemical binding]; other site 373994001179 dimerization interface [polypeptide binding]; other site 373994001180 product binding site; other site 373994001181 substrate binding site [chemical binding]; other site 373994001182 zinc binding site [ion binding]; other site 373994001183 catalytic residues [active] 373994001184 Protein of unknown function (DUF760); Region: DUF760; pfam05542 373994001185 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 373994001186 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 373994001187 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373994001188 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373994001189 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373994001190 DNA binding residues [nucleotide binding] 373994001191 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 373994001192 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 373994001193 ATP-grasp domain; Region: ATP-grasp_4; cl17255 373994001194 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 373994001195 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 373994001196 ATP-grasp domain; Region: ATP-grasp_4; cl17255 373994001197 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 373994001198 IMP binding site; other site 373994001199 dimer interface [polypeptide binding]; other site 373994001200 interdomain contacts; other site 373994001201 partial ornithine binding site; other site 373994001202 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 373994001203 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 373994001204 dimerization interface [polypeptide binding]; other site 373994001205 DPS ferroxidase diiron center [ion binding]; other site 373994001206 ion pore; other site 373994001207 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 373994001208 dimer interface [polypeptide binding]; other site 373994001209 [2Fe-2S] cluster binding site [ion binding]; other site 373994001210 excinuclease ABC subunit B; Provisional; Region: PRK05298 373994001211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994001212 ATP binding site [chemical binding]; other site 373994001213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994001214 nucleotide binding region [chemical binding]; other site 373994001215 ATP-binding site [chemical binding]; other site 373994001216 Ultra-violet resistance protein B; Region: UvrB; pfam12344 373994001217 UvrB/uvrC motif; Region: UVR; pfam02151 373994001218 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 373994001219 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 373994001220 substrate binding site [chemical binding]; other site 373994001221 hexamer interface [polypeptide binding]; other site 373994001222 metal binding site [ion binding]; metal-binding site 373994001223 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 373994001224 active site 373994001225 catalytic residues [active] 373994001226 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 373994001227 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994001228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994001229 binding surface 373994001230 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994001231 TPR motif; other site 373994001232 Uncharacterized conserved protein [Function unknown]; Region: COG4278 373994001233 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 373994001234 AAA ATPase domain; Region: AAA_16; pfam13191 373994001235 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994001236 serpin-like protein; Provisional; Region: PHA02660 373994001237 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 373994001238 reactive center loop; other site 373994001239 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 373994001240 Domain of unknown function DUF20; Region: UPF0118; pfam01594 373994001241 Transcriptional regulator [Transcription]; Region: LytR; COG1316 373994001242 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 373994001243 hydrolase, alpha/beta fold family protein; Region: PLN02824 373994001244 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994001245 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 373994001246 putative catalytic residue [active] 373994001247 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 373994001248 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 373994001249 putative nucleotide binding site [chemical binding]; other site 373994001250 uridine monophosphate binding site [chemical binding]; other site 373994001251 homohexameric interface [polypeptide binding]; other site 373994001252 ribosome recycling factor; Reviewed; Region: frr; PRK00083 373994001253 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 373994001254 hinge region; other site 373994001255 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 373994001256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994001257 hydroxyglutarate oxidase; Provisional; Region: PRK11728 373994001258 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 373994001259 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 373994001260 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 373994001261 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373994001262 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 373994001263 serine racemase; Region: PLN02970 373994001264 tetramer interface [polypeptide binding]; other site 373994001265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994001266 catalytic residue [active] 373994001267 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 373994001268 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 373994001269 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 373994001270 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 373994001271 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373994001272 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 373994001273 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373994001274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994001275 putative substrate translocation pore; other site 373994001276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994001277 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 373994001278 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 373994001279 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 373994001280 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 373994001281 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 373994001282 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 373994001283 tartrate dehydrogenase; Region: TTC; TIGR02089 373994001284 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 373994001285 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 373994001286 Walker A/P-loop; other site 373994001287 ATP binding site [chemical binding]; other site 373994001288 Q-loop/lid; other site 373994001289 ABC transporter signature motif; other site 373994001290 Walker B; other site 373994001291 D-loop; other site 373994001292 H-loop/switch region; other site 373994001293 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 373994001294 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 373994001295 Walker A/P-loop; other site 373994001296 ATP binding site [chemical binding]; other site 373994001297 Q-loop/lid; other site 373994001298 ABC transporter signature motif; other site 373994001299 Walker B; other site 373994001300 D-loop; other site 373994001301 H-loop/switch region; other site 373994001302 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 373994001303 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 373994001304 CoA binding domain; Region: CoA_binding; smart00881 373994001305 CoA-ligase; Region: Ligase_CoA; pfam00549 373994001306 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 373994001307 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 373994001308 CoA-ligase; Region: Ligase_CoA; pfam00549 373994001309 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373994001310 HSP70 interaction site [polypeptide binding]; other site 373994001311 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 373994001312 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 373994001313 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 373994001314 tetramer interface [polypeptide binding]; other site 373994001315 TPP-binding site [chemical binding]; other site 373994001316 heterodimer interface [polypeptide binding]; other site 373994001317 phosphorylation loop region [posttranslational modification] 373994001318 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 373994001319 active site 373994001320 catalytic residues [active] 373994001321 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 373994001322 intersubunit interface [polypeptide binding]; other site 373994001323 active site 373994001324 zinc binding site [ion binding]; other site 373994001325 Na+ binding site [ion binding]; other site 373994001326 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 373994001327 nitrilase; Region: PLN02798 373994001328 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 373994001329 putative active site [active] 373994001330 catalytic triad [active] 373994001331 dimer interface [polypeptide binding]; other site 373994001332 Predicted flavoprotein [General function prediction only]; Region: COG0431 373994001333 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 373994001334 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 373994001335 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 373994001336 Walker A/P-loop; other site 373994001337 ATP binding site [chemical binding]; other site 373994001338 Q-loop/lid; other site 373994001339 ABC transporter signature motif; other site 373994001340 Walker B; other site 373994001341 D-loop; other site 373994001342 H-loop/switch region; other site 373994001343 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373994001344 AAA domain; Region: AAA_31; pfam13614 373994001345 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 373994001346 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 373994001347 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994001348 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 373994001349 Walker A/P-loop; other site 373994001350 ATP binding site [chemical binding]; other site 373994001351 Q-loop/lid; other site 373994001352 ABC transporter signature motif; other site 373994001353 Walker B; other site 373994001354 D-loop; other site 373994001355 H-loop/switch region; other site 373994001356 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 373994001357 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994001358 active site 373994001359 Bacterial sugar transferase; Region: Bac_transf; cl00939 373994001360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994001361 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994001362 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 373994001363 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 373994001364 metal-binding site 373994001365 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 373994001366 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 373994001367 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 373994001368 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 373994001369 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 373994001370 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 373994001371 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 373994001372 active site 373994001373 dimer interface [polypeptide binding]; other site 373994001374 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 373994001375 Ligand Binding Site [chemical binding]; other site 373994001376 Molecular Tunnel; other site 373994001377 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 373994001378 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994001379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994001380 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 373994001381 Walker A/P-loop; other site 373994001382 ATP binding site [chemical binding]; other site 373994001383 Q-loop/lid; other site 373994001384 ABC transporter signature motif; other site 373994001385 Walker B; other site 373994001386 D-loop; other site 373994001387 H-loop/switch region; other site 373994001388 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 373994001389 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 373994001390 transmembrane helices; other site 373994001391 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 373994001392 TrkA-C domain; Region: TrkA_C; pfam02080 373994001393 TrkA-C domain; Region: TrkA_C; pfam02080 373994001394 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 373994001395 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 373994001396 ligand-binding site [chemical binding]; other site 373994001397 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 373994001398 ATP-sulfurylase; Region: ATPS; cd00517 373994001399 active site 373994001400 HXXH motif; other site 373994001401 flexible loop; other site 373994001402 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994001403 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994001404 active site 373994001405 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 373994001406 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994001407 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994001408 O-Antigen ligase; Region: Wzy_C; cl04850 373994001409 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994001410 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373994001411 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 373994001412 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 373994001413 putative ADP-binding pocket [chemical binding]; other site 373994001414 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 373994001415 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 373994001416 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 373994001417 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 373994001418 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 373994001419 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 373994001420 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 373994001421 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 373994001422 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 373994001423 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 373994001424 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 373994001425 hinge; other site 373994001426 active site 373994001427 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 373994001428 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 373994001429 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 373994001430 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 373994001431 ATP binding site [chemical binding]; other site 373994001432 substrate interface [chemical binding]; other site 373994001433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994001434 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 373994001435 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 373994001436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994001437 active site 373994001438 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 373994001439 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994001440 active site 373994001441 ATP binding site [chemical binding]; other site 373994001442 substrate binding site [chemical binding]; other site 373994001443 activation loop (A-loop); other site 373994001444 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 373994001445 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 373994001446 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 373994001447 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 373994001448 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373994001449 PAS fold; Region: PAS_4; pfam08448 373994001450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994001451 putative active site [active] 373994001452 heme pocket [chemical binding]; other site 373994001453 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994001454 PAS fold; Region: PAS_4; pfam08448 373994001455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994001456 putative active site [active] 373994001457 heme pocket [chemical binding]; other site 373994001458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994001459 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994001460 putative active site [active] 373994001461 heme pocket [chemical binding]; other site 373994001462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994001463 putative active site [active] 373994001464 heme pocket [chemical binding]; other site 373994001465 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994001466 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 373994001467 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 373994001468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994001469 ATP binding site [chemical binding]; other site 373994001470 Mg2+ binding site [ion binding]; other site 373994001471 G-X-G motif; other site 373994001472 MoxR-like ATPases [General function prediction only]; Region: COG0714 373994001473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994001474 ATP binding site [chemical binding]; other site 373994001475 Walker A motif; other site 373994001476 Walker B motif; other site 373994001477 arginine finger; other site 373994001478 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 373994001479 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 373994001480 active site 373994001481 Riboflavin kinase; Region: Flavokinase; pfam01687 373994001482 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 373994001483 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 373994001484 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 373994001485 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 373994001486 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 373994001487 dimer interface [polypeptide binding]; other site 373994001488 motif 1; other site 373994001489 active site 373994001490 motif 2; other site 373994001491 motif 3; other site 373994001492 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 373994001493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994001494 ATP binding site [chemical binding]; other site 373994001495 putative Mg++ binding site [ion binding]; other site 373994001496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994001497 nucleotide binding region [chemical binding]; other site 373994001498 ATP-binding site [chemical binding]; other site 373994001499 HEAT repeats; Region: HEAT_2; pfam13646 373994001500 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 373994001501 protein binding surface [polypeptide binding]; other site 373994001502 HEAT repeats; Region: HEAT_2; pfam13646 373994001503 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 373994001504 NACHT domain; Region: NACHT; pfam05729 373994001505 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994001506 Bacterial SH3 domain; Region: SH3_3; pfam08239 373994001507 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 373994001508 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 373994001509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994001510 Coenzyme A binding pocket [chemical binding]; other site 373994001511 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 373994001512 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 373994001513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994001514 FeS/SAM binding site; other site 373994001515 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 373994001516 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994001517 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994001518 active site 373994001519 ATP binding site [chemical binding]; other site 373994001520 substrate binding site [chemical binding]; other site 373994001521 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994001522 substrate binding site [chemical binding]; other site 373994001523 activation loop (A-loop); other site 373994001524 activation loop (A-loop); other site 373994001525 AAA ATPase domain; Region: AAA_16; pfam13191 373994001526 Predicted ATPase [General function prediction only]; Region: COG3899 373994001527 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994001528 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994001529 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994001530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994001531 dimer interface [polypeptide binding]; other site 373994001532 phosphorylation site [posttranslational modification] 373994001533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994001534 ATP binding site [chemical binding]; other site 373994001535 Mg2+ binding site [ion binding]; other site 373994001536 G-X-G motif; other site 373994001537 Protein kinase domain; Region: Pkinase; pfam00069 373994001538 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994001539 active site 373994001540 ATP binding site [chemical binding]; other site 373994001541 substrate binding site [chemical binding]; other site 373994001542 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994001543 substrate binding site [chemical binding]; other site 373994001544 activation loop (A-loop); other site 373994001545 activation loop (A-loop); other site 373994001546 AAA ATPase domain; Region: AAA_16; pfam13191 373994001547 Predicted ATPase [General function prediction only]; Region: COG3899 373994001548 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994001549 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994001550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994001551 dimer interface [polypeptide binding]; other site 373994001552 phosphorylation site [posttranslational modification] 373994001553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994001554 ATP binding site [chemical binding]; other site 373994001555 Mg2+ binding site [ion binding]; other site 373994001556 G-X-G motif; other site 373994001557 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 373994001558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994001559 dimer interface [polypeptide binding]; other site 373994001560 phosphorylation site [posttranslational modification] 373994001561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994001562 ATP binding site [chemical binding]; other site 373994001563 Mg2+ binding site [ion binding]; other site 373994001564 G-X-G motif; other site 373994001565 Response regulator receiver domain; Region: Response_reg; pfam00072 373994001566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994001567 active site 373994001568 phosphorylation site [posttranslational modification] 373994001569 intermolecular recognition site; other site 373994001570 dimerization interface [polypeptide binding]; other site 373994001571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373994001572 DNA-binding site [nucleotide binding]; DNA binding site 373994001573 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 373994001574 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373994001575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994001576 homodimer interface [polypeptide binding]; other site 373994001577 catalytic residue [active] 373994001578 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 373994001579 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373994001580 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994001581 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994001582 active site 373994001583 2-isopropylmalate synthase; Validated; Region: PRK00915 373994001584 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 373994001585 active site 373994001586 catalytic residues [active] 373994001587 metal binding site [ion binding]; metal-binding site 373994001588 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 373994001589 Uncharacterized conserved protein [Function unknown]; Region: COG1432 373994001590 LabA_like proteins; Region: LabA; cd10911 373994001591 putative metal binding site [ion binding]; other site 373994001592 CHASE2 domain; Region: CHASE2; pfam05226 373994001593 Protein kinase domain; Region: Pkinase; pfam00069 373994001594 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994001595 active site 373994001596 ATP binding site [chemical binding]; other site 373994001597 substrate binding site [chemical binding]; other site 373994001598 activation loop (A-loop); other site 373994001599 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 373994001600 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 373994001601 active site residue [active] 373994001602 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 373994001603 active site residue [active] 373994001604 Uncharacterized conserved protein [Function unknown]; Region: COG4121 373994001605 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 373994001606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994001607 active site 373994001608 phosphorylation site [posttranslational modification] 373994001609 intermolecular recognition site; other site 373994001610 dimerization interface [polypeptide binding]; other site 373994001611 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373994001612 Zn2+ binding site [ion binding]; other site 373994001613 Mg2+ binding site [ion binding]; other site 373994001614 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 373994001615 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 373994001616 Substrate binding site; other site 373994001617 Mg++ binding site; other site 373994001618 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 373994001619 active site 373994001620 substrate binding site [chemical binding]; other site 373994001621 CoA binding site [chemical binding]; other site 373994001622 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 373994001623 active site 373994001624 dimer interface [polypeptide binding]; other site 373994001625 catalytic nucleophile [active] 373994001626 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 373994001627 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994001628 GAF domain; Region: GAF; cl17456 373994001629 GAF domain; Region: GAF; pfam01590 373994001630 GAF domain; Region: GAF; pfam01590 373994001631 GAF domain; Region: GAF; cl17456 373994001632 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 373994001633 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 373994001634 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 373994001635 quinone interaction residues [chemical binding]; other site 373994001636 active site 373994001637 catalytic residues [active] 373994001638 FMN binding site [chemical binding]; other site 373994001639 substrate binding site [chemical binding]; other site 373994001640 TROVE domain; Region: TROVE; pfam05731 373994001641 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 373994001642 metal ion-dependent adhesion site (MIDAS); other site 373994001643 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 373994001644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994001645 motif II; other site 373994001646 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 373994001647 GTP binding site; other site 373994001648 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 373994001649 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 373994001650 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 373994001651 [4Fe-4S] binding site [ion binding]; other site 373994001652 molybdopterin cofactor binding site; other site 373994001653 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 373994001654 molybdopterin cofactor binding site; other site 373994001655 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 373994001656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994001657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994001658 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 373994001659 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 373994001660 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 373994001661 HEAT repeats; Region: HEAT_2; pfam13646 373994001662 HEAT repeats; Region: HEAT_2; pfam13646 373994001663 HEAT repeats; Region: HEAT_2; pfam13646 373994001664 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 373994001665 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 373994001666 dimerization interface [polypeptide binding]; other site 373994001667 ATP binding site [chemical binding]; other site 373994001668 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 373994001669 dimerization interface [polypeptide binding]; other site 373994001670 ATP binding site [chemical binding]; other site 373994001671 amidophosphoribosyltransferase; Provisional; Region: PRK07349 373994001672 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 373994001673 active site 373994001674 tetramer interface [polypeptide binding]; other site 373994001675 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373994001676 active site 373994001677 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 373994001678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994001679 dimer interface [polypeptide binding]; other site 373994001680 conserved gate region; other site 373994001681 putative PBP binding loops; other site 373994001682 ABC-ATPase subunit interface; other site 373994001683 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373994001684 active site 373994001685 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 373994001686 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 373994001687 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994001688 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 373994001689 phosphopeptide binding site; other site 373994001690 Transglycosylase; Region: Transgly; pfam00912 373994001691 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 373994001692 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 373994001693 large tegument protein UL36; Provisional; Region: PHA03247 373994001694 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 373994001695 lipoprotein signal peptidase; Provisional; Region: PRK14787 373994001696 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 373994001697 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 373994001698 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 373994001699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994001700 dimer interface [polypeptide binding]; other site 373994001701 conserved gate region; other site 373994001702 putative PBP binding loops; other site 373994001703 ABC-ATPase subunit interface; other site 373994001704 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 373994001705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994001706 dimer interface [polypeptide binding]; other site 373994001707 conserved gate region; other site 373994001708 putative PBP binding loops; other site 373994001709 ABC-ATPase subunit interface; other site 373994001710 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 373994001711 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 373994001712 Walker A/P-loop; other site 373994001713 ATP binding site [chemical binding]; other site 373994001714 Q-loop/lid; other site 373994001715 ABC transporter signature motif; other site 373994001716 Walker B; other site 373994001717 D-loop; other site 373994001718 H-loop/switch region; other site 373994001719 Response regulator receiver domain; Region: Response_reg; pfam00072 373994001720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994001721 active site 373994001722 phosphorylation site [posttranslational modification] 373994001723 intermolecular recognition site; other site 373994001724 dimerization interface [polypeptide binding]; other site 373994001725 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994001726 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994001727 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994001728 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994001729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994001730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994001731 dimer interface [polypeptide binding]; other site 373994001732 phosphorylation site [posttranslational modification] 373994001733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994001734 ATP binding site [chemical binding]; other site 373994001735 Mg2+ binding site [ion binding]; other site 373994001736 G-X-G motif; other site 373994001737 Response regulator receiver domain; Region: Response_reg; pfam00072 373994001738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994001739 active site 373994001740 phosphorylation site [posttranslational modification] 373994001741 intermolecular recognition site; other site 373994001742 dimerization interface [polypeptide binding]; other site 373994001743 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 373994001744 cyclase homology domain; Region: CHD; cd07302 373994001745 nucleotidyl binding site; other site 373994001746 metal binding site [ion binding]; metal-binding site 373994001747 dimer interface [polypeptide binding]; other site 373994001748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 373994001749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 373994001750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994001751 Coenzyme A binding pocket [chemical binding]; other site 373994001752 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 373994001753 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373994001754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994001755 homodimer interface [polypeptide binding]; other site 373994001756 catalytic residue [active] 373994001757 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 373994001758 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373994001759 glutathione reductase; Validated; Region: PRK06116 373994001760 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373994001761 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994001762 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 373994001763 glutathione reductase; Validated; Region: PRK06116 373994001764 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994001765 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 373994001766 Phycobilisome protein; Region: Phycobilisome; cl08227 373994001767 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 373994001768 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 373994001769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994001770 S-adenosylmethionine binding site [chemical binding]; other site 373994001771 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 373994001772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 373994001773 ATP binding site [chemical binding]; other site 373994001774 Mg2+ binding site [ion binding]; other site 373994001775 G-X-G motif; other site 373994001776 Protein of unknown function (DUF342); Region: DUF342; pfam03961 373994001777 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 373994001778 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 373994001779 putative dimer interface [polypeptide binding]; other site 373994001780 putative anticodon binding site; other site 373994001781 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 373994001782 homodimer interface [polypeptide binding]; other site 373994001783 motif 1; other site 373994001784 motif 2; other site 373994001785 active site 373994001786 motif 3; other site 373994001787 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994001788 putative active site [active] 373994001789 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 373994001790 active site 373994001791 M28 Zn-Peptidases; Region: M28_like_1; cd05640 373994001792 Peptidase family M28; Region: Peptidase_M28; pfam04389 373994001793 metal binding site [ion binding]; metal-binding site 373994001794 hypothetical protein; Provisional; Region: PRK00766 373994001795 Protein of unknown function DUF99; Region: DUF99; pfam01949 373994001796 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 373994001797 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550 373994001798 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 373994001799 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 373994001800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 373994001801 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994001802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994001803 TPR motif; other site 373994001804 CHAT domain; Region: CHAT; cl17868 373994001805 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 373994001806 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 373994001807 sulfate transport protein; Provisional; Region: cysT; CHL00187 373994001808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994001809 dimer interface [polypeptide binding]; other site 373994001810 conserved gate region; other site 373994001811 putative PBP binding loops; other site 373994001812 ABC-ATPase subunit interface; other site 373994001813 sulfate transport protein; Provisional; Region: cysT; CHL00187 373994001814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994001815 dimer interface [polypeptide binding]; other site 373994001816 conserved gate region; other site 373994001817 putative PBP binding loops; other site 373994001818 ABC-ATPase subunit interface; other site 373994001819 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994001820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994001821 active site 373994001822 phosphorylation site [posttranslational modification] 373994001823 intermolecular recognition site; other site 373994001824 dimerization interface [polypeptide binding]; other site 373994001825 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994001826 DNA binding residues [nucleotide binding] 373994001827 dimerization interface [polypeptide binding]; other site 373994001828 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 373994001829 oligomerisation interface [polypeptide binding]; other site 373994001830 mobile loop; other site 373994001831 roof hairpin; other site 373994001832 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 373994001833 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 373994001834 ring oligomerisation interface [polypeptide binding]; other site 373994001835 ATP/Mg binding site [chemical binding]; other site 373994001836 stacking interactions; other site 373994001837 hinge regions; other site 373994001838 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 373994001839 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 373994001840 active site 373994001841 NTP binding site [chemical binding]; other site 373994001842 metal binding triad [ion binding]; metal-binding site 373994001843 antibiotic binding site [chemical binding]; other site 373994001844 Uncharacterized conserved protein [Function unknown]; Region: COG2361 373994001845 Predicted transcriptional regulators [Transcription]; Region: COG1695 373994001846 Transcriptional regulator PadR-like family; Region: PadR; cl17335 373994001847 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 373994001848 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994001849 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994001850 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994001851 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 373994001852 Protein export membrane protein; Region: SecD_SecF; cl14618 373994001853 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 373994001854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994001855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994001856 dimer interface [polypeptide binding]; other site 373994001857 phosphorylation site [posttranslational modification] 373994001858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994001859 ATP binding site [chemical binding]; other site 373994001860 Mg2+ binding site [ion binding]; other site 373994001861 G-X-G motif; other site 373994001862 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994001863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994001864 active site 373994001865 phosphorylation site [posttranslational modification] 373994001866 intermolecular recognition site; other site 373994001867 dimerization interface [polypeptide binding]; other site 373994001868 Response regulator receiver domain; Region: Response_reg; pfam00072 373994001869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994001870 active site 373994001871 phosphorylation site [posttranslational modification] 373994001872 intermolecular recognition site; other site 373994001873 dimerization interface [polypeptide binding]; other site 373994001874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 373994001875 dimer interface [polypeptide binding]; other site 373994001876 phosphorylation site [posttranslational modification] 373994001877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994001878 ATP binding site [chemical binding]; other site 373994001879 Mg2+ binding site [ion binding]; other site 373994001880 G-X-G motif; other site 373994001881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994001882 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 373994001883 Coenzyme A binding pocket [chemical binding]; other site 373994001884 AAA domain; Region: AAA_33; pfam13671 373994001885 AAA domain; Region: AAA_17; pfam13207 373994001886 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 373994001887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994001888 Coenzyme A binding pocket [chemical binding]; other site 373994001889 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 373994001890 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 373994001891 DNA binding residues [nucleotide binding] 373994001892 putative dimer interface [polypeptide binding]; other site 373994001893 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 373994001894 Clp amino terminal domain; Region: Clp_N; pfam02861 373994001895 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 373994001896 Cytochrome P450; Region: p450; pfam00067 373994001897 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994001898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994001899 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 373994001900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994001901 S-adenosylmethionine binding site [chemical binding]; other site 373994001902 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 373994001903 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 373994001904 alpha-gamma subunit interface [polypeptide binding]; other site 373994001905 beta-gamma subunit interface [polypeptide binding]; other site 373994001906 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 373994001907 alpha-beta subunit interface [polypeptide binding]; other site 373994001908 Cupin domain; Region: Cupin_2; cl17218 373994001909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994001910 S-adenosylmethionine binding site [chemical binding]; other site 373994001911 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 373994001912 nucleotide binding site/active site [active] 373994001913 HIT family signature motif; other site 373994001914 catalytic residue [active] 373994001915 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 373994001916 urease subunit alpha; Reviewed; Region: ureC; PRK13207 373994001917 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 373994001918 subunit interactions [polypeptide binding]; other site 373994001919 active site 373994001920 flap region; other site 373994001921 Response regulator receiver domain; Region: Response_reg; pfam00072 373994001922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994001923 active site 373994001924 phosphorylation site [posttranslational modification] 373994001925 intermolecular recognition site; other site 373994001926 dimerization interface [polypeptide binding]; other site 373994001927 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994001928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994001929 dimer interface [polypeptide binding]; other site 373994001930 phosphorylation site [posttranslational modification] 373994001931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994001932 ATP binding site [chemical binding]; other site 373994001933 Mg2+ binding site [ion binding]; other site 373994001934 G-X-G motif; other site 373994001935 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 373994001936 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 373994001937 NAD(P) binding site [chemical binding]; other site 373994001938 catalytic residues [active] 373994001939 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 373994001940 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 373994001941 Moco binding site; other site 373994001942 metal coordination site [ion binding]; other site 373994001943 ribosomal protein L32; Validated; Region: rpl32; CHL00152 373994001944 Caspase domain; Region: Peptidase_C14; pfam00656 373994001945 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 373994001946 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 373994001947 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 373994001948 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 373994001949 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 373994001950 dihydrodipicolinate synthase; Region: dapA; TIGR00674 373994001951 dimer interface [polypeptide binding]; other site 373994001952 active site 373994001953 catalytic residue [active] 373994001954 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 373994001955 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 373994001956 trigger factor; Provisional; Region: tig; PRK01490 373994001957 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 373994001958 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 373994001959 Clp protease; Region: CLP_protease; pfam00574 373994001960 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 373994001961 oligomer interface [polypeptide binding]; other site 373994001962 active site residues [active] 373994001963 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 373994001964 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 373994001965 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 373994001966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994001967 Walker A motif; other site 373994001968 ATP binding site [chemical binding]; other site 373994001969 Walker B motif; other site 373994001970 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 373994001971 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994001972 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994001973 Predicted transcriptional regulators [Transcription]; Region: COG1725 373994001974 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373994001975 DNA-binding site [nucleotide binding]; DNA binding site 373994001976 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 373994001977 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 373994001978 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 373994001979 RNA binding site [nucleotide binding]; other site 373994001980 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 373994001981 RNA binding site [nucleotide binding]; other site 373994001982 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 373994001983 RNA binding site [nucleotide binding]; other site 373994001984 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 373994001985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994001986 non-specific DNA binding site [nucleotide binding]; other site 373994001987 salt bridge; other site 373994001988 sequence-specific DNA binding site [nucleotide binding]; other site 373994001989 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 373994001990 Family description; Region: UvrD_C_2; pfam13538 373994001991 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 373994001992 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373994001993 putative active site [active] 373994001994 putative metal binding site [ion binding]; other site 373994001995 quinolinate synthetase; Provisional; Region: PRK09375 373994001996 Predicted acetyltransferase [General function prediction only]; Region: COG3393 373994001997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 373994001998 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 373994001999 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 373994002000 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 373994002001 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 373994002002 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 373994002003 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 373994002004 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 373994002005 Predicted integral membrane protein [Function unknown]; Region: COG0762 373994002006 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 373994002007 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 373994002008 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 373994002009 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 373994002010 Protein of unknown function (DUF98); Region: DUF98; pfam01947 373994002011 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 373994002012 cytochrome c biogenesis protein; Region: ccsA; CHL00045 373994002013 tellurite resistance protein terB; Region: terB; cd07176 373994002014 putative metal binding site [ion binding]; other site 373994002015 Methyltransferase domain; Region: Methyltransf_26; pfam13659 373994002016 hydroxyglutarate oxidase; Provisional; Region: PRK11728 373994002017 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 373994002018 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 373994002019 TIGR02452 family protein; Region: TIGR02452 373994002020 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 373994002021 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 373994002022 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 373994002023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994002024 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 373994002025 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 373994002026 active site 373994002027 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373994002028 dimer interface [polypeptide binding]; other site 373994002029 substrate binding site [chemical binding]; other site 373994002030 catalytic residues [active] 373994002031 Response regulator receiver domain; Region: Response_reg; pfam00072 373994002032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002033 active site 373994002034 phosphorylation site [posttranslational modification] 373994002035 intermolecular recognition site; other site 373994002036 dimerization interface [polypeptide binding]; other site 373994002037 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 373994002038 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 373994002039 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 373994002040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994002041 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 373994002042 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 373994002043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373994002044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994002045 homodimer interface [polypeptide binding]; other site 373994002046 catalytic residue [active] 373994002047 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 373994002048 IHF dimer interface [polypeptide binding]; other site 373994002049 IHF - DNA interface [nucleotide binding]; other site 373994002050 AMIN domain; Region: AMIN; pfam11741 373994002051 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 373994002052 Secretin and TonB N terminus short domain; Region: STN; pfam07660 373994002053 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 373994002054 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 373994002055 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 373994002056 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 373994002057 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 373994002058 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 373994002059 Cell division protein FtsA; Region: FtsA; cl17206 373994002060 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 373994002061 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373994002062 Photosystem II protein Y (PsbY); Region: PsbY; cl05675 373994002063 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 373994002064 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 373994002065 trimer interface [polypeptide binding]; other site 373994002066 putative metal binding site [ion binding]; other site 373994002067 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 373994002068 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 373994002069 active site 373994002070 metal binding site [ion binding]; metal-binding site 373994002071 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 373994002072 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 373994002073 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 373994002074 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 373994002075 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 373994002076 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 373994002077 methionine aminopeptidase; Provisional; Region: PRK12318 373994002078 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 373994002079 active site 373994002080 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 373994002081 Fe-S cluster binding site [ion binding]; other site 373994002082 active site 373994002083 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373994002084 active site 373994002085 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994002086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994002087 binding surface 373994002088 TPR motif; other site 373994002089 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994002090 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994002091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994002092 binding surface 373994002093 TPR motif; other site 373994002094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994002095 binding surface 373994002096 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994002097 TPR motif; other site 373994002098 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994002099 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994002100 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994002101 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994002102 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994002103 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994002104 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 373994002105 putative hexamer interface [polypeptide binding]; other site 373994002106 putative hexagonal pore; other site 373994002107 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 373994002108 Hexamer interface [polypeptide binding]; other site 373994002109 Hexagonal pore residue; other site 373994002110 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 373994002111 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994002112 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994002113 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994002114 Pirin-related protein [General function prediction only]; Region: COG1741 373994002115 Pirin; Region: Pirin; pfam02678 373994002116 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 373994002117 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 373994002118 dimerization interface [polypeptide binding]; other site 373994002119 DPS ferroxidase diiron center [ion binding]; other site 373994002120 ion pore; other site 373994002121 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 373994002122 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 373994002123 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373994002124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994002125 homodimer interface [polypeptide binding]; other site 373994002126 catalytic residue [active] 373994002127 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 373994002128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994002129 active site 373994002130 motif I; other site 373994002131 motif II; other site 373994002132 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 373994002133 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 373994002134 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 373994002135 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994002136 active site 373994002137 ATP binding site [chemical binding]; other site 373994002138 substrate binding site [chemical binding]; other site 373994002139 activation loop (A-loop); other site 373994002140 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 373994002141 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 373994002142 ribosomal protein S20; Region: rps20; CHL00102 373994002143 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 373994002144 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 373994002145 active site 373994002146 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 373994002147 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 373994002148 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 373994002149 RPB1 interaction site [polypeptide binding]; other site 373994002150 RPB10 interaction site [polypeptide binding]; other site 373994002151 RPB11 interaction site [polypeptide binding]; other site 373994002152 RPB3 interaction site [polypeptide binding]; other site 373994002153 RPB12 interaction site [polypeptide binding]; other site 373994002154 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 373994002155 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 373994002156 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 373994002157 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 373994002158 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 373994002159 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 373994002160 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 373994002161 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 373994002162 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 373994002163 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 373994002164 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 373994002165 DNA binding site [nucleotide binding] 373994002166 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 373994002167 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 373994002168 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 373994002169 Cellulose binding domain; Region: CBM_2; pfam00553 373994002170 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 373994002171 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 373994002172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994002173 binding surface 373994002174 TPR motif; other site 373994002175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994002176 binding surface 373994002177 TPR motif; other site 373994002178 TPR repeat; Region: TPR_11; pfam13414 373994002179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994002180 TPR motif; other site 373994002181 binding surface 373994002182 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994002183 putative active site [active] 373994002184 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 373994002185 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 373994002186 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 373994002187 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 373994002188 DXD motif; other site 373994002189 PilZ domain; Region: PilZ; pfam07238 373994002190 CAAX protease self-immunity; Region: Abi; pfam02517 373994002191 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 373994002192 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 373994002193 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994002194 catalytic loop [active] 373994002195 iron binding site [ion binding]; other site 373994002196 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 373994002197 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 373994002198 substrate binding site [chemical binding]; other site 373994002199 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 373994002200 substrate binding site [chemical binding]; other site 373994002201 ligand binding site [chemical binding]; other site 373994002202 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 373994002203 homotrimer interaction site [polypeptide binding]; other site 373994002204 putative active site [active] 373994002205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994002206 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994002207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994002208 EamA-like transporter family; Region: EamA; cl17759 373994002209 EamA-like transporter family; Region: EamA; pfam00892 373994002210 Response regulator receiver domain; Region: Response_reg; pfam00072 373994002211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002212 active site 373994002213 phosphorylation site [posttranslational modification] 373994002214 intermolecular recognition site; other site 373994002215 dimerization interface [polypeptide binding]; other site 373994002216 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373994002217 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 373994002218 FOG: CBS domain [General function prediction only]; Region: COG0517 373994002219 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994002220 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994002221 putative active site [active] 373994002222 heme pocket [chemical binding]; other site 373994002223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994002224 putative active site [active] 373994002225 heme pocket [chemical binding]; other site 373994002226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994002227 PAS fold; Region: PAS_3; pfam08447 373994002228 putative active site [active] 373994002229 heme pocket [chemical binding]; other site 373994002230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994002231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994002232 dimer interface [polypeptide binding]; other site 373994002233 phosphorylation site [posttranslational modification] 373994002234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994002235 ATP binding site [chemical binding]; other site 373994002236 Mg2+ binding site [ion binding]; other site 373994002237 G-X-G motif; other site 373994002238 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 373994002239 active site 373994002240 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 373994002241 SmpB-tmRNA interface; other site 373994002242 Tic20-like protein; Region: Tic20; pfam09685 373994002243 thiamine monophosphate kinase; Provisional; Region: PRK05731 373994002244 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 373994002245 ATP binding site [chemical binding]; other site 373994002246 dimerization interface [polypeptide binding]; other site 373994002247 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 373994002248 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 373994002249 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 373994002250 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 373994002251 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 373994002252 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373994002253 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373994002254 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 373994002255 FAD binding domain; Region: FAD_binding_4; pfam01565 373994002256 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 373994002257 hypothetical protein; Validated; Region: PRK00153 373994002258 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 373994002259 Low molecular weight phosphatase family; Region: LMWPc; cd00115 373994002260 active site 373994002261 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 373994002262 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 373994002263 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373994002264 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 373994002265 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 373994002266 Nucleotide binding site [chemical binding]; other site 373994002267 DTAP/Switch II; other site 373994002268 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 373994002269 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 373994002270 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 373994002271 cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156 373994002272 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 373994002273 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 373994002274 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 373994002275 inhibitor-cofactor binding pocket; inhibition site 373994002276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994002277 catalytic residue [active] 373994002278 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994002279 GAF domain; Region: GAF; pfam01590 373994002280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994002281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994002282 dimer interface [polypeptide binding]; other site 373994002283 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 373994002284 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 373994002285 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 373994002286 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994002287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002288 active site 373994002289 phosphorylation site [posttranslational modification] 373994002290 intermolecular recognition site; other site 373994002291 dimerization interface [polypeptide binding]; other site 373994002292 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994002293 DNA binding residues [nucleotide binding] 373994002294 dimerization interface [polypeptide binding]; other site 373994002295 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 373994002296 iron-sulfur cluster [ion binding]; other site 373994002297 [2Fe-2S] cluster binding site [ion binding]; other site 373994002298 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 373994002299 Pheophorbide a oxygenase; Region: PaO; pfam08417 373994002300 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 373994002301 Predicted membrane protein [Function unknown]; Region: COG1981 373994002302 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 373994002303 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 373994002304 Walker A/P-loop; other site 373994002305 ATP binding site [chemical binding]; other site 373994002306 Q-loop/lid; other site 373994002307 ABC transporter signature motif; other site 373994002308 Walker B; other site 373994002309 D-loop; other site 373994002310 H-loop/switch region; other site 373994002311 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373994002312 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 373994002313 substrate binding pocket [chemical binding]; other site 373994002314 membrane-bound complex binding site; other site 373994002315 hinge residues; other site 373994002316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994002317 dimer interface [polypeptide binding]; other site 373994002318 conserved gate region; other site 373994002319 putative PBP binding loops; other site 373994002320 ABC-ATPase subunit interface; other site 373994002321 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994002322 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994002323 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994002324 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 373994002325 ligand binding site [chemical binding]; other site 373994002326 active site 373994002327 UGI interface [polypeptide binding]; other site 373994002328 catalytic site [active] 373994002329 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 373994002330 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 373994002331 Ligand Binding Site [chemical binding]; other site 373994002332 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 373994002333 Response regulator receiver domain; Region: Response_reg; pfam00072 373994002334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002335 active site 373994002336 phosphorylation site [posttranslational modification] 373994002337 intermolecular recognition site; other site 373994002338 dimerization interface [polypeptide binding]; other site 373994002339 Response regulator receiver domain; Region: Response_reg; pfam00072 373994002340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002341 active site 373994002342 phosphorylation site [posttranslational modification] 373994002343 intermolecular recognition site; other site 373994002344 dimerization interface [polypeptide binding]; other site 373994002345 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 373994002346 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994002347 binding surface 373994002348 TPR motif; other site 373994002349 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994002350 dimerization interface [polypeptide binding]; other site 373994002351 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373994002352 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373994002353 dimer interface [polypeptide binding]; other site 373994002354 putative CheW interface [polypeptide binding]; other site 373994002355 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373994002356 putative binding surface; other site 373994002357 active site 373994002358 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 373994002359 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 373994002360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994002361 ATP binding site [chemical binding]; other site 373994002362 Mg2+ binding site [ion binding]; other site 373994002363 G-X-G motif; other site 373994002364 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 373994002365 Response regulator receiver domain; Region: Response_reg; pfam00072 373994002366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002367 active site 373994002368 phosphorylation site [posttranslational modification] 373994002369 intermolecular recognition site; other site 373994002370 dimerization interface [polypeptide binding]; other site 373994002371 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 373994002372 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373994002373 Protein of unknown function DUF262; Region: DUF262; pfam03235 373994002374 Uncharacterized conserved protein [Function unknown]; Region: COG1479 373994002375 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 373994002376 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 373994002377 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373994002378 active site 373994002379 metal binding site [ion binding]; metal-binding site 373994002380 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 373994002381 DNA primase, catalytic core; Region: dnaG; TIGR01391 373994002382 CHC2 zinc finger; Region: zf-CHC2; pfam01807 373994002383 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 373994002384 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 373994002385 active site 373994002386 metal binding site [ion binding]; metal-binding site 373994002387 interdomain interaction site; other site 373994002388 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 373994002389 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994002390 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994002391 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994002392 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792 373994002393 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 373994002394 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 373994002395 TPR repeat; Region: TPR_11; pfam13414 373994002396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994002397 binding surface 373994002398 TPR motif; other site 373994002399 TPR repeat; Region: TPR_11; pfam13414 373994002400 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994002401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994002402 TPR motif; other site 373994002403 MEKHLA domain; Region: MEKHLA; pfam08670 373994002404 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994002405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002406 active site 373994002407 phosphorylation site [posttranslational modification] 373994002408 intermolecular recognition site; other site 373994002409 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994002410 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994002411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994002412 dimer interface [polypeptide binding]; other site 373994002413 phosphorylation site [posttranslational modification] 373994002414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994002415 ATP binding site [chemical binding]; other site 373994002416 Mg2+ binding site [ion binding]; other site 373994002417 G-X-G motif; other site 373994002418 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 373994002419 nudix motif; other site 373994002420 4-alpha-glucanotransferase; Provisional; Region: PRK14508 373994002421 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 373994002422 Helix-turn-helix domain; Region: HTH_25; pfam13413 373994002423 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 373994002424 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 373994002425 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373994002426 RNA binding surface [nucleotide binding]; other site 373994002427 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 373994002428 active site 373994002429 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 373994002430 phosphatidate cytidylyltransferase; Region: PLN02953 373994002431 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 373994002432 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 373994002433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994002434 S-adenosylmethionine binding site [chemical binding]; other site 373994002435 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994002436 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994002437 active site 373994002438 ATP binding site [chemical binding]; other site 373994002439 substrate binding site [chemical binding]; other site 373994002440 activation loop (A-loop); other site 373994002441 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 373994002442 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 373994002443 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373994002444 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 373994002445 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 373994002446 ATP-grasp domain; Region: ATP-grasp_4; cl17255 373994002447 ATP-grasp domain; Region: ATP-grasp_4; cl17255 373994002448 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373994002449 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373994002450 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 373994002451 proposed catalytic triad [active] 373994002452 active site nucleophile [active] 373994002453 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 373994002454 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 373994002455 homotrimer interaction site [polypeptide binding]; other site 373994002456 zinc binding site [ion binding]; other site 373994002457 CDP-binding sites; other site 373994002458 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 373994002459 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 373994002460 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 373994002461 AIR carboxylase; Region: AIRC; smart01001 373994002462 argininosuccinate lyase; Provisional; Region: PRK00855 373994002463 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 373994002464 active sites [active] 373994002465 tetramer interface [polypeptide binding]; other site 373994002466 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 373994002467 nudix motif; other site 373994002468 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994002469 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 373994002470 nucleophilic elbow; other site 373994002471 catalytic triad; other site 373994002472 pantothenate kinase; Reviewed; Region: PRK13331 373994002473 HEAT repeats; Region: HEAT_2; pfam13646 373994002474 HEAT repeats; Region: HEAT_2; pfam13646 373994002475 HEAT repeats; Region: HEAT_2; pfam13646 373994002476 HEAT repeats; Region: HEAT_2; pfam13646 373994002477 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 373994002478 HEAT repeats; Region: HEAT_2; pfam13646 373994002479 protein binding surface [polypeptide binding]; other site 373994002480 HEAT repeats; Region: HEAT_2; pfam13646 373994002481 HEAT repeats; Region: HEAT_2; pfam13646 373994002482 HEAT repeats; Region: HEAT_2; pfam13646 373994002483 HEAT repeats; Region: HEAT_2; pfam13646 373994002484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 373994002485 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 373994002486 Probable transposase; Region: OrfB_IS605; pfam01385 373994002487 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 373994002488 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 373994002489 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 373994002490 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 373994002491 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 373994002492 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 373994002493 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 373994002494 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 373994002495 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 373994002496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994002497 Helix-turn-helix domain; Region: HTH_18; pfam12833 373994002498 CpeS-like protein; Region: CpeS; pfam09367 373994002499 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994002500 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994002501 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 373994002502 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994002503 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994002504 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994002505 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994002506 active site 373994002507 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 373994002508 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 373994002509 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 373994002510 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 373994002511 putative homodimer interface [polypeptide binding]; other site 373994002512 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 373994002513 heterodimer interface [polypeptide binding]; other site 373994002514 homodimer interface [polypeptide binding]; other site 373994002515 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 373994002516 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 373994002517 23S rRNA interface [nucleotide binding]; other site 373994002518 L7/L12 interface [polypeptide binding]; other site 373994002519 putative thiostrepton binding site; other site 373994002520 L25 interface [polypeptide binding]; other site 373994002521 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 373994002522 mRNA/rRNA interface [nucleotide binding]; other site 373994002523 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 373994002524 23S rRNA interface [nucleotide binding]; other site 373994002525 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 373994002526 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 373994002527 core dimer interface [polypeptide binding]; other site 373994002528 peripheral dimer interface [polypeptide binding]; other site 373994002529 L10 interface [polypeptide binding]; other site 373994002530 L11 interface [polypeptide binding]; other site 373994002531 putative EF-Tu interaction site [polypeptide binding]; other site 373994002532 putative EF-G interaction site [polypeptide binding]; other site 373994002533 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994002534 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994002535 active site 373994002536 ATP binding site [chemical binding]; other site 373994002537 substrate binding site [chemical binding]; other site 373994002538 activation loop (A-loop); other site 373994002539 Helix-turn-helix domain; Region: HTH_17; pfam12728 373994002540 Clp protease ATP binding subunit; Region: clpC; CHL00095 373994002541 Clp amino terminal domain; Region: Clp_N; pfam02861 373994002542 Clp amino terminal domain; Region: Clp_N; pfam02861 373994002543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994002544 Walker A motif; other site 373994002545 ATP binding site [chemical binding]; other site 373994002546 Walker B motif; other site 373994002547 arginine finger; other site 373994002548 UvrB/uvrC motif; Region: UVR; pfam02151 373994002549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994002550 Walker A motif; other site 373994002551 ATP binding site [chemical binding]; other site 373994002552 Walker B motif; other site 373994002553 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 373994002554 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 373994002555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994002556 Coenzyme A binding pocket [chemical binding]; other site 373994002557 diaminopimelate decarboxylase; Region: lysA; TIGR01048 373994002558 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 373994002559 active site 373994002560 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373994002561 substrate binding site [chemical binding]; other site 373994002562 catalytic residues [active] 373994002563 dimer interface [polypeptide binding]; other site 373994002564 Uncharacterized conserved protein [Function unknown]; Region: COG1624 373994002565 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 373994002566 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 373994002567 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 373994002568 catalytic residue [active] 373994002569 putative FPP diphosphate binding site; other site 373994002570 putative FPP binding hydrophobic cleft; other site 373994002571 dimer interface [polypeptide binding]; other site 373994002572 putative IPP diphosphate binding site; other site 373994002573 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 373994002574 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373994002575 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 373994002576 HSP70 interaction site [polypeptide binding]; other site 373994002577 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 373994002578 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373994002579 HSP70 interaction site [polypeptide binding]; other site 373994002580 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 373994002581 dimer interface [polypeptide binding]; other site 373994002582 molecular chaperone DnaK; Provisional; Region: PRK13410 373994002583 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 373994002584 nucleotide binding site [chemical binding]; other site 373994002585 NEF interaction site [polypeptide binding]; other site 373994002586 SBD interface [polypeptide binding]; other site 373994002587 M28 Zn-Peptidases; Region: M28_like_1; cd05640 373994002588 Peptidase family M28; Region: Peptidase_M28; pfam04389 373994002589 metal binding site [ion binding]; metal-binding site 373994002590 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 373994002591 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 373994002592 acyl-activating enzyme (AAE) consensus motif; other site 373994002593 AMP binding site [chemical binding]; other site 373994002594 active site 373994002595 CoA binding site [chemical binding]; other site 373994002596 Response regulator receiver domain; Region: Response_reg; pfam00072 373994002597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002598 active site 373994002599 phosphorylation site [posttranslational modification] 373994002600 intermolecular recognition site; other site 373994002601 dimerization interface [polypeptide binding]; other site 373994002602 Peptidase family S41; Region: Peptidase_S41; pfam03572 373994002603 Active site serine [active] 373994002604 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 373994002605 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 373994002606 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994002607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 373994002608 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 373994002609 O-Antigen ligase; Region: Wzy_C; pfam04932 373994002610 ferredoxin-sulfite reductase; Region: sir; TIGR02042 373994002611 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 373994002612 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 373994002613 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 373994002614 Uncharacterized conserved protein [Function unknown]; Region: COG5464 373994002615 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 373994002616 CHAT domain; Region: CHAT; pfam12770 373994002617 Domain of unknown function (DUF389); Region: DUF389; pfam04087 373994002618 RNA methyltransferase, RsmE family; Region: TIGR00046 373994002619 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 373994002620 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373994002621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 373994002622 TPR motif; other site 373994002623 carotene isomerase; Region: carot_isom; TIGR02730 373994002624 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994002625 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994002626 Homeodomain-like domain; Region: HTH_23; pfam13384 373994002627 Winged helix-turn helix; Region: HTH_29; pfam13551 373994002628 Homeodomain-like domain; Region: HTH_32; pfam13565 373994002629 Winged helix-turn helix; Region: HTH_33; pfam13592 373994002630 DDE superfamily endonuclease; Region: DDE_3; pfam13358 373994002631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 373994002632 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 373994002633 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 373994002634 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 373994002635 Animal haem peroxidase; Region: An_peroxidase; pfam03098 373994002636 heme binding site [chemical binding]; other site 373994002637 substrate binding site [chemical binding]; other site 373994002638 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994002639 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 373994002640 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 373994002641 Walker A/P-loop; other site 373994002642 ATP binding site [chemical binding]; other site 373994002643 Q-loop/lid; other site 373994002644 ABC transporter signature motif; other site 373994002645 Walker B; other site 373994002646 D-loop; other site 373994002647 H-loop/switch region; other site 373994002648 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994002649 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994002650 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994002651 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994002652 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994002653 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994002654 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994002655 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 373994002656 Lipase (class 2); Region: Lipase_2; pfam01674 373994002657 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373994002658 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 373994002659 active site 373994002660 metal binding site [ion binding]; metal-binding site 373994002661 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 373994002662 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 373994002663 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994002664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994002665 S-adenosylmethionine binding site [chemical binding]; other site 373994002666 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 373994002667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994002668 FeS/SAM binding site; other site 373994002669 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 373994002670 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 373994002671 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 373994002672 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 373994002673 catalytic residues [active] 373994002674 Right handed beta helix region; Region: Beta_helix; pfam13229 373994002675 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 373994002676 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 373994002677 putative NAD(P) binding site [chemical binding]; other site 373994002678 NACHT domain; Region: NACHT; pfam05729 373994002679 Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900 373994002680 ADP-ribose binding site [chemical binding]; other site 373994002681 putative active site [active] 373994002682 dimer interface [polypeptide binding]; other site 373994002683 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 373994002684 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 373994002685 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 373994002686 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 373994002687 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 373994002688 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 373994002689 putative catalytic site [active] 373994002690 putative phosphate binding site [ion binding]; other site 373994002691 active site 373994002692 metal binding site A [ion binding]; metal-binding site 373994002693 DNA binding site [nucleotide binding] 373994002694 putative AP binding site [nucleotide binding]; other site 373994002695 putative metal binding site B [ion binding]; other site 373994002696 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 373994002697 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 373994002698 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994002699 Domain of unknown function (DUF389); Region: DUF389; pfam04087 373994002700 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 373994002701 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 373994002702 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 373994002703 catalytic triad [active] 373994002704 putative active site [active] 373994002705 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 373994002706 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 373994002707 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 373994002708 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 373994002709 catalytic site [active] 373994002710 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 373994002711 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 373994002712 active site 373994002713 catalytic residues [active] 373994002714 Integral membrane protein DUF92; Region: DUF92; pfam01940 373994002715 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 373994002716 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 373994002717 HEAT repeats; Region: HEAT_2; pfam13646 373994002718 HEAT repeats; Region: HEAT_2; pfam13646 373994002719 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994002720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002721 active site 373994002722 phosphorylation site [posttranslational modification] 373994002723 intermolecular recognition site; other site 373994002724 dimerization interface [polypeptide binding]; other site 373994002725 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994002726 DNA binding site [nucleotide binding] 373994002727 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994002728 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994002729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 373994002730 dimer interface [polypeptide binding]; other site 373994002731 phosphorylation site [posttranslational modification] 373994002732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994002733 ATP binding site [chemical binding]; other site 373994002734 Mg2+ binding site [ion binding]; other site 373994002735 G-X-G motif; other site 373994002736 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 373994002737 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 373994002738 active site 373994002739 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994002740 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994002741 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373994002742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994002743 homodimer interface [polypeptide binding]; other site 373994002744 catalytic residue [active] 373994002745 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 373994002746 active site 373994002747 catalytic residues [active] 373994002748 metal binding site [ion binding]; metal-binding site 373994002749 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 373994002750 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 373994002751 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 373994002752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994002753 putative substrate translocation pore; other site 373994002754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994002755 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 373994002756 PGAP1-like protein; Region: PGAP1; pfam07819 373994002757 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 373994002758 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 373994002759 active site 373994002760 multimer interface [polypeptide binding]; other site 373994002761 arginine decarboxylase; Provisional; Region: PRK05354 373994002762 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 373994002763 dimer interface [polypeptide binding]; other site 373994002764 active site 373994002765 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373994002766 catalytic residues [active] 373994002767 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 373994002768 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 373994002769 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 373994002770 active site 373994002771 Substrate binding site; other site 373994002772 Mg++ binding site; other site 373994002773 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 373994002774 putative trimer interface [polypeptide binding]; other site 373994002775 putative CoA binding site [chemical binding]; other site 373994002776 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 373994002777 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 373994002778 Domain of unknown function DUF20; Region: UPF0118; pfam01594 373994002779 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 373994002780 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 373994002781 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 373994002782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994002783 TPR repeat; Region: TPR_11; pfam13414 373994002784 TPR motif; other site 373994002785 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 373994002786 TPR repeat; Region: TPR_11; pfam13414 373994002787 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 373994002788 feedback inhibition sensing region; other site 373994002789 homohexameric interface [polypeptide binding]; other site 373994002790 nucleotide binding site [chemical binding]; other site 373994002791 N-acetyl-L-glutamate binding site [chemical binding]; other site 373994002792 shikimate kinase; Reviewed; Region: aroK; PRK00131 373994002793 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 373994002794 ADP binding site [chemical binding]; other site 373994002795 magnesium binding site [ion binding]; other site 373994002796 putative shikimate binding site; other site 373994002797 AAA ATPase domain; Region: AAA_16; pfam13191 373994002798 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 373994002799 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 373994002800 aromatic acid decarboxylase; Validated; Region: PRK05920 373994002801 Flavoprotein; Region: Flavoprotein; pfam02441 373994002802 Exoribonuclease R [Transcription]; Region: VacB; COG0557 373994002803 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 373994002804 RNB domain; Region: RNB; pfam00773 373994002805 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 373994002806 RNA binding site [nucleotide binding]; other site 373994002807 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 373994002808 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 373994002809 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 373994002810 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 373994002811 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 373994002812 Rubredoxin [Energy production and conversion]; Region: COG1773 373994002813 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 373994002814 iron binding site [ion binding]; other site 373994002815 Ycf48-like protein; Provisional; Region: PRK13684 373994002816 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 373994002817 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 373994002818 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 373994002819 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 373994002820 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 373994002821 photosystem II reaction center protein J; Provisional; Region: PRK02565 373994002822 photosystem I subunit VIII; Validated; Region: psaI; CHL00186 373994002823 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 373994002824 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373994002825 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373994002826 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373994002827 DNA binding residues [nucleotide binding] 373994002828 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 373994002829 AAA ATPase domain; Region: AAA_16; pfam13191 373994002830 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994002831 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994002832 structural tetrad; other site 373994002833 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994002834 structural tetrad; other site 373994002835 WD40 repeats; Region: WD40; smart00320 373994002836 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 373994002837 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 373994002838 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 373994002839 cell division protein FtsZ; Validated; Region: PRK09330 373994002840 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 373994002841 nucleotide binding site [chemical binding]; other site 373994002842 SulA interaction site; other site 373994002843 glutathione synthetase; Provisional; Region: PRK05246 373994002844 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 373994002845 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 373994002846 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 373994002847 GSH binding site [chemical binding]; other site 373994002848 catalytic residues [active] 373994002849 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 373994002850 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 373994002851 HflX GTPase family; Region: HflX; cd01878 373994002852 G1 box; other site 373994002853 GTP/Mg2+ binding site [chemical binding]; other site 373994002854 Switch I region; other site 373994002855 G2 box; other site 373994002856 G3 box; other site 373994002857 Switch II region; other site 373994002858 G4 box; other site 373994002859 G5 box; other site 373994002860 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994002861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002862 active site 373994002863 phosphorylation site [posttranslational modification] 373994002864 intermolecular recognition site; other site 373994002865 dimerization interface [polypeptide binding]; other site 373994002866 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994002867 DNA binding site [nucleotide binding] 373994002868 Response regulator receiver domain; Region: Response_reg; pfam00072 373994002869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002870 active site 373994002871 phosphorylation site [posttranslational modification] 373994002872 intermolecular recognition site; other site 373994002873 dimerization interface [polypeptide binding]; other site 373994002874 Response regulator receiver domain; Region: Response_reg; pfam00072 373994002875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002876 active site 373994002877 phosphorylation site [posttranslational modification] 373994002878 intermolecular recognition site; other site 373994002879 dimerization interface [polypeptide binding]; other site 373994002880 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373994002881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373994002882 metal binding site [ion binding]; metal-binding site 373994002883 active site 373994002884 I-site; other site 373994002885 Response regulator receiver domain; Region: Response_reg; pfam00072 373994002886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002887 active site 373994002888 phosphorylation site [posttranslational modification] 373994002889 intermolecular recognition site; other site 373994002890 dimerization interface [polypeptide binding]; other site 373994002891 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994002892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002893 active site 373994002894 phosphorylation site [posttranslational modification] 373994002895 intermolecular recognition site; other site 373994002896 dimerization interface [polypeptide binding]; other site 373994002897 BON domain; Region: BON; pfam04972 373994002898 BON domain; Region: BON; pfam04972 373994002899 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 373994002900 ligand binding site [chemical binding]; other site 373994002901 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 373994002902 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 373994002903 Rab subfamily motif 1 (RabSF1); other site 373994002904 G1 box; other site 373994002905 GTP/Mg2+ binding site [chemical binding]; other site 373994002906 Rab subfamily motif 2 (RabSF2); other site 373994002907 Switch I region; other site 373994002908 G2 box; other site 373994002909 effector interaction site; other site 373994002910 GDI interaction site; other site 373994002911 Rab family motif 1 (RabF1); other site 373994002912 GEF interaction site [polypeptide binding]; other site 373994002913 Rab family motif 2 (RabF2); other site 373994002914 G3 box; other site 373994002915 Switch II region; other site 373994002916 Rab family motif 3 (RabF3); other site 373994002917 Rab family motif 4 (RabF4); other site 373994002918 Rab family motif 5 (RabF5); other site 373994002919 Rab subfamily motif 3 (RabSF3); other site 373994002920 G4 box; other site 373994002921 G5 box; other site 373994002922 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994002923 PAS domain; Region: PAS_9; pfam13426 373994002924 putative active site [active] 373994002925 heme pocket [chemical binding]; other site 373994002926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994002927 dimer interface [polypeptide binding]; other site 373994002928 phosphorylation site [posttranslational modification] 373994002929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994002930 ATP binding site [chemical binding]; other site 373994002931 Mg2+ binding site [ion binding]; other site 373994002932 G-X-G motif; other site 373994002933 Response regulator receiver domain; Region: Response_reg; pfam00072 373994002934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002935 active site 373994002936 phosphorylation site [posttranslational modification] 373994002937 intermolecular recognition site; other site 373994002938 dimerization interface [polypeptide binding]; other site 373994002939 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373994002940 putative binding surface; other site 373994002941 active site 373994002942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994002943 TPR repeat; Region: TPR_11; pfam13414 373994002944 binding surface 373994002945 TPR motif; other site 373994002946 TPR repeat; Region: TPR_11; pfam13414 373994002947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994002948 binding surface 373994002949 TPR motif; other site 373994002950 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 373994002951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994002952 FeS/SAM binding site; other site 373994002953 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 373994002954 PAS fold; Region: PAS; pfam00989 373994002955 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994002956 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994002957 DNA binding residues [nucleotide binding] 373994002958 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 373994002959 protein I interface; other site 373994002960 D2 interface; other site 373994002961 protein T interface; other site 373994002962 chlorophyll binding site; other site 373994002963 beta carotene binding site; other site 373994002964 pheophytin binding site; other site 373994002965 manganese-stabilizing polypeptide interface; other site 373994002966 CP43 interface; other site 373994002967 protein L interface; other site 373994002968 oxygen evolving complex binding site; other site 373994002969 bromide binding site; other site 373994002970 quinone binding site; other site 373994002971 Fe binding site [ion binding]; other site 373994002972 core light harvesting interface; other site 373994002973 cytochrome b559 alpha subunit interface; other site 373994002974 cytochrome c-550 interface; other site 373994002975 protein J interface; other site 373994002976 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 373994002977 Caspase domain; Region: Peptidase_C14; pfam00656 373994002978 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 373994002979 ATP-sulfurylase; Region: ATPS; cd00517 373994002980 active site 373994002981 HXXH motif; other site 373994002982 flexible loop; other site 373994002983 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994002984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994002985 active site 373994002986 phosphorylation site [posttranslational modification] 373994002987 intermolecular recognition site; other site 373994002988 dimerization interface [polypeptide binding]; other site 373994002989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994002990 DNA binding site [nucleotide binding] 373994002991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994002992 dimer interface [polypeptide binding]; other site 373994002993 phosphorylation site [posttranslational modification] 373994002994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994002995 ATP binding site [chemical binding]; other site 373994002996 Mg2+ binding site [ion binding]; other site 373994002997 G-X-G motif; other site 373994002998 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 373994002999 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994003000 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373994003001 protein binding site [polypeptide binding]; other site 373994003002 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 373994003003 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 373994003004 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 373994003005 Uncharacterized conserved protein [Function unknown]; Region: COG0062 373994003006 putative carbohydrate kinase; Provisional; Region: PRK10565 373994003007 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 373994003008 putative substrate binding site [chemical binding]; other site 373994003009 putative ATP binding site [chemical binding]; other site 373994003010 glutaminase A; Region: Gln_ase; TIGR03814 373994003011 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 373994003012 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 373994003013 Glutaminase; Region: Glutaminase; cl00907 373994003014 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 373994003015 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 373994003016 AAA ATPase domain; Region: AAA_16; pfam13191 373994003017 HEAT repeats; Region: HEAT_2; pfam13646 373994003018 HEAT repeats; Region: HEAT_2; pfam13646 373994003019 GUN4-like; Region: GUN4; pfam05419 373994003020 FAD binding domain; Region: FAD_binding_4; pfam01565 373994003021 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 373994003022 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 373994003023 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994003024 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994003025 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 373994003026 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994003027 DevC protein; Region: devC; TIGR01185 373994003028 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994003029 FtsX-like permease family; Region: FtsX; pfam02687 373994003030 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 373994003031 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 373994003032 Walker A/P-loop; other site 373994003033 ATP binding site [chemical binding]; other site 373994003034 Q-loop/lid; other site 373994003035 ABC transporter signature motif; other site 373994003036 Walker B; other site 373994003037 D-loop; other site 373994003038 H-loop/switch region; other site 373994003039 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 373994003040 active site 373994003041 catalytic triad [active] 373994003042 oxyanion hole [active] 373994003043 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 373994003044 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 373994003045 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 373994003046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994003047 Mg2+ binding site [ion binding]; other site 373994003048 G-X-G motif; other site 373994003049 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 373994003050 anchoring element; other site 373994003051 dimer interface [polypeptide binding]; other site 373994003052 ATP binding site [chemical binding]; other site 373994003053 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 373994003054 protein-splicing catalytic site; other site 373994003055 thioester formation/cholesterol transfer; other site 373994003056 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 373994003057 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 373994003058 thioester formation/cholesterol transfer; other site 373994003059 protein-splicing catalytic site; other site 373994003060 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 373994003061 active site 373994003062 putative metal-binding site [ion binding]; other site 373994003063 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 373994003064 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 373994003065 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 373994003066 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373994003067 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373994003068 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373994003069 DNA binding residues [nucleotide binding] 373994003070 light-harvesting-like protein 3; Provisional; Region: PLN00014 373994003071 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 373994003072 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994003073 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994003074 structural tetrad; other site 373994003075 DNA gyrase subunit A; Validated; Region: PRK05560 373994003076 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 373994003077 CAP-like domain; other site 373994003078 active site 373994003079 primary dimer interface [polypeptide binding]; other site 373994003080 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373994003081 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373994003082 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373994003083 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994003084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994003085 active site 373994003086 phosphorylation site [posttranslational modification] 373994003087 intermolecular recognition site; other site 373994003088 dimerization interface [polypeptide binding]; other site 373994003089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994003090 binding surface 373994003091 TPR motif; other site 373994003092 TPR repeat; Region: TPR_11; pfam13414 373994003093 TPR repeat; Region: TPR_11; pfam13414 373994003094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994003095 binding surface 373994003096 TPR motif; other site 373994003097 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 373994003098 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994003099 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994003100 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994003101 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 373994003102 FtsX-like permease family; Region: FtsX; pfam02687 373994003103 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 373994003104 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 373994003105 Walker A/P-loop; other site 373994003106 ATP binding site [chemical binding]; other site 373994003107 Q-loop/lid; other site 373994003108 ABC transporter signature motif; other site 373994003109 Walker B; other site 373994003110 D-loop; other site 373994003111 H-loop/switch region; other site 373994003112 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 373994003113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994003114 motif II; other site 373994003115 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 373994003116 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 373994003117 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 373994003118 SnoaL-like domain; Region: SnoaL_2; pfam12680 373994003119 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 373994003120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 373994003121 ATP binding site [chemical binding]; other site 373994003122 Mg2+ binding site [ion binding]; other site 373994003123 G-X-G motif; other site 373994003124 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994003125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994003126 active site 373994003127 phosphorylation site [posttranslational modification] 373994003128 intermolecular recognition site; other site 373994003129 dimerization interface [polypeptide binding]; other site 373994003130 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994003131 GAF domain; Region: GAF; cl17456 373994003132 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 373994003133 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 373994003134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994003135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994003136 active site 373994003137 phosphorylation site [posttranslational modification] 373994003138 intermolecular recognition site; other site 373994003139 dimerization interface [polypeptide binding]; other site 373994003140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994003141 DNA binding residues [nucleotide binding] 373994003142 dimerization interface [polypeptide binding]; other site 373994003143 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 373994003144 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 373994003145 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 373994003146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994003147 Walker A/P-loop; other site 373994003148 ATP binding site [chemical binding]; other site 373994003149 Q-loop/lid; other site 373994003150 ABC transporter signature motif; other site 373994003151 Walker B; other site 373994003152 D-loop; other site 373994003153 H-loop/switch region; other site 373994003154 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994003155 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994003156 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 373994003157 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 373994003158 Peptidase family M48; Region: Peptidase_M48; pfam01435 373994003159 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 373994003160 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373994003161 active site 373994003162 metal binding site [ion binding]; metal-binding site 373994003163 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 373994003164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994003165 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373994003166 putative substrate translocation pore; other site 373994003167 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 373994003168 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 373994003169 S-formylglutathione hydrolase; Region: PLN02442 373994003170 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994003171 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994003172 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 373994003173 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994003174 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 373994003175 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 373994003176 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 373994003177 catalytic triad [active] 373994003178 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 373994003179 anti sigma factor interaction site; other site 373994003180 regulatory phosphorylation site [posttranslational modification]; other site 373994003181 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 373994003182 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 373994003183 B12 binding site [chemical binding]; other site 373994003184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994003185 FeS/SAM binding site; other site 373994003186 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 373994003187 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 373994003188 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 373994003189 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 373994003190 homodimer interface [polypeptide binding]; other site 373994003191 oligonucleotide binding site [chemical binding]; other site 373994003192 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 373994003193 RNA/DNA hybrid binding site [nucleotide binding]; other site 373994003194 active site 373994003195 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 373994003196 prephenate dehydratase; Provisional; Region: PRK11898 373994003197 Prephenate dehydratase; Region: PDT; pfam00800 373994003198 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 373994003199 putative L-Phe binding site [chemical binding]; other site 373994003200 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 373994003201 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 373994003202 elongation factor Tu; Region: tufA; CHL00071 373994003203 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 373994003204 G1 box; other site 373994003205 GEF interaction site [polypeptide binding]; other site 373994003206 GTP/Mg2+ binding site [chemical binding]; other site 373994003207 Switch I region; other site 373994003208 G2 box; other site 373994003209 G3 box; other site 373994003210 Switch II region; other site 373994003211 G4 box; other site 373994003212 G5 box; other site 373994003213 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 373994003214 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 373994003215 Antibiotic Binding Site [chemical binding]; other site 373994003216 elongation factor G; Reviewed; Region: PRK00007 373994003217 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 373994003218 G1 box; other site 373994003219 putative GEF interaction site [polypeptide binding]; other site 373994003220 GTP/Mg2+ binding site [chemical binding]; other site 373994003221 Switch I region; other site 373994003222 G2 box; other site 373994003223 G3 box; other site 373994003224 Switch II region; other site 373994003225 G4 box; other site 373994003226 G5 box; other site 373994003227 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 373994003228 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 373994003229 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 373994003230 30S ribosomal protein S7; Validated; Region: PRK05302 373994003231 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 373994003232 S17 interaction site [polypeptide binding]; other site 373994003233 S8 interaction site; other site 373994003234 16S rRNA interaction site [nucleotide binding]; other site 373994003235 streptomycin interaction site [chemical binding]; other site 373994003236 23S rRNA interaction site [nucleotide binding]; other site 373994003237 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 373994003238 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 373994003239 Cupin domain; Region: Cupin_2; cl17218 373994003240 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 373994003241 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 373994003242 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 373994003243 active site 373994003244 dimer interface [polypeptide binding]; other site 373994003245 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 373994003246 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 373994003247 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 373994003248 active site 373994003249 FMN binding site [chemical binding]; other site 373994003250 substrate binding site [chemical binding]; other site 373994003251 3Fe-4S cluster binding site [ion binding]; other site 373994003252 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 373994003253 domain interface; other site 373994003254 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 373994003255 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 373994003256 NodB motif; other site 373994003257 active site 373994003258 catalytic site [active] 373994003259 metal binding site [ion binding]; metal-binding site 373994003260 Predicted integral membrane protein [Function unknown]; Region: COG5542 373994003261 Uncharacterized protein family UPF0546; Region: UPF0546; pfam10639 373994003262 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 373994003263 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 373994003264 Ligand binding site; other site 373994003265 Putative Catalytic site; other site 373994003266 DXD motif; other site 373994003267 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994003268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994003269 S-adenosylmethionine binding site [chemical binding]; other site 373994003270 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 373994003271 Predicted membrane protein [Function unknown]; Region: COG3463 373994003272 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 373994003273 Predicted integral membrane protein [Function unknown]; Region: COG5542 373994003274 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 373994003275 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 373994003276 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 373994003277 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 373994003278 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 373994003279 active site 373994003280 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 373994003281 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 373994003282 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994003283 putative active site [active] 373994003284 PAS fold; Region: PAS_3; pfam08447 373994003285 heme pocket [chemical binding]; other site 373994003286 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 373994003287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994003288 dimer interface [polypeptide binding]; other site 373994003289 phosphorylation site [posttranslational modification] 373994003290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994003291 ATP binding site [chemical binding]; other site 373994003292 Mg2+ binding site [ion binding]; other site 373994003293 G-X-G motif; other site 373994003294 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 373994003295 S-layer homology domain; Region: SLH; pfam00395 373994003296 S-layer homology domain; Region: SLH; pfam00395 373994003297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994003298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994003299 dimer interface [polypeptide binding]; other site 373994003300 phosphorylation site [posttranslational modification] 373994003301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994003302 ATP binding site [chemical binding]; other site 373994003303 Mg2+ binding site [ion binding]; other site 373994003304 G-X-G motif; other site 373994003305 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994003306 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994003307 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994003308 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994003309 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994003310 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994003311 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 373994003312 active site 373994003313 catalytic residues [active] 373994003314 metal binding site [ion binding]; metal-binding site 373994003315 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 373994003316 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 373994003317 DHH family; Region: DHH; pfam01368 373994003318 DHHA1 domain; Region: DHHA1; pfam02272 373994003319 Uncharacterized conserved protein [Function unknown]; Region: COG1434 373994003320 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 373994003321 putative active site [active] 373994003322 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 373994003323 C-terminal peptidase (prc); Region: prc; TIGR00225 373994003324 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 373994003325 protein binding site [polypeptide binding]; other site 373994003326 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 373994003327 Catalytic dyad [active] 373994003328 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994003329 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994003330 active site 373994003331 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994003332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994003333 active site 373994003334 phosphorylation site [posttranslational modification] 373994003335 intermolecular recognition site; other site 373994003336 dimerization interface [polypeptide binding]; other site 373994003337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994003338 DNA binding residues [nucleotide binding] 373994003339 dimerization interface [polypeptide binding]; other site 373994003340 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 373994003341 Double zinc ribbon; Region: DZR; pfam12773 373994003342 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 373994003343 Protein phosphatase 2C; Region: PP2C; pfam00481 373994003344 active site 373994003345 CHAT domain; Region: CHAT; cl17868 373994003346 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 373994003347 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994003348 phosphopeptide binding site; other site 373994003349 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994003350 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 373994003351 phosphopeptide binding site; other site 373994003352 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 373994003353 intracellular protease, PfpI family; Region: PfpI; TIGR01382 373994003354 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 373994003355 conserved cys residue [active] 373994003356 hypothetical protein; Provisional; Region: PRK07394 373994003357 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 373994003358 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 373994003359 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373994003360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994003361 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 373994003362 dimerization interface [polypeptide binding]; other site 373994003363 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 373994003364 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 373994003365 iron-sulfur cluster [ion binding]; other site 373994003366 [2Fe-2S] cluster binding site [ion binding]; other site 373994003367 Predicted membrane protein [Function unknown]; Region: COG3431 373994003368 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 373994003369 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 373994003370 tetramerization interface [polypeptide binding]; other site 373994003371 active site 373994003372 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 373994003373 dimer interface [polypeptide binding]; other site 373994003374 substrate binding site [chemical binding]; other site 373994003375 metal binding sites [ion binding]; metal-binding site 373994003376 Uncharacterized conserved protein [Function unknown]; Region: COG2006 373994003377 Domain of unknown function (DUF362); Region: DUF362; pfam04015 373994003378 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 373994003379 Aspartase; Region: Aspartase; cd01357 373994003380 active sites [active] 373994003381 tetramer interface [polypeptide binding]; other site 373994003382 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 373994003383 hypothetical protein; Provisional; Region: PRK06185 373994003384 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 373994003385 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 373994003386 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373994003387 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 373994003388 putative NAD(P) binding site [chemical binding]; other site 373994003389 active site 373994003390 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 373994003391 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994003392 putative ADP-binding pocket [chemical binding]; other site 373994003393 Bacterial sugar transferase; Region: Bac_transf; pfam02397 373994003394 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 373994003395 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 373994003396 NADP-binding site; other site 373994003397 homotetramer interface [polypeptide binding]; other site 373994003398 substrate binding site [chemical binding]; other site 373994003399 homodimer interface [polypeptide binding]; other site 373994003400 active site 373994003401 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 373994003402 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 373994003403 NADP binding site [chemical binding]; other site 373994003404 active site 373994003405 putative substrate binding site [chemical binding]; other site 373994003406 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 373994003407 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 373994003408 Coenzyme A binding pocket [chemical binding]; other site 373994003409 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 373994003410 iron-sulfur cluster [ion binding]; other site 373994003411 [2Fe-2S] cluster binding site [ion binding]; other site 373994003412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994003413 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994003414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994003415 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 373994003416 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 373994003417 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994003418 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994003419 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994003420 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994003421 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994003422 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994003423 GAF domain; Region: GAF_2; pfam13185 373994003424 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994003425 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994003426 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994003427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994003428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994003429 dimer interface [polypeptide binding]; other site 373994003430 phosphorylation site [posttranslational modification] 373994003431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994003432 ATP binding site [chemical binding]; other site 373994003433 Mg2+ binding site [ion binding]; other site 373994003434 G-X-G motif; other site 373994003435 Bacterial sugar transferase; Region: Bac_transf; pfam02397 373994003436 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994003437 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994003438 ligand binding site [chemical binding]; other site 373994003439 flexible hinge region; other site 373994003440 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 373994003441 putative switch regulator; other site 373994003442 non-specific DNA interactions [nucleotide binding]; other site 373994003443 DNA binding site [nucleotide binding] 373994003444 sequence specific DNA binding site [nucleotide binding]; other site 373994003445 putative cAMP binding site [chemical binding]; other site 373994003446 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 373994003447 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 373994003448 active site pocket [active] 373994003449 putative dimer interface [polypeptide binding]; other site 373994003450 putative cataytic base [active] 373994003451 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 373994003452 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 373994003453 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 373994003454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994003455 S-adenosylmethionine binding site [chemical binding]; other site 373994003456 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 373994003457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994003458 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 373994003459 dimerization interface [polypeptide binding]; other site 373994003460 substrate binding pocket [chemical binding]; other site 373994003461 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 373994003462 Protein of unknown function (DUF433); Region: DUF433; pfam04255 373994003463 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 373994003464 Peptidase family U32; Region: Peptidase_U32; pfam01136 373994003465 Collagenase; Region: DUF3656; pfam12392 373994003466 Peptidase family U32; Region: Peptidase_U32; cl03113 373994003467 PemK-like protein; Region: PemK; pfam02452 373994003468 Uncharacterized conserved protein [Function unknown]; Region: COG1479 373994003469 Protein of unknown function DUF262; Region: DUF262; pfam03235 373994003470 Divergent AAA domain; Region: AAA_4; pfam04326 373994003471 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 373994003472 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373994003473 active site 373994003474 catalytic tetrad [active] 373994003475 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373994003476 Bifunctional nuclease; Region: DNase-RNase; pfam02577 373994003477 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 373994003478 Lumazine binding domain; Region: Lum_binding; pfam00677 373994003479 Lumazine binding domain; Region: Lum_binding; pfam00677 373994003480 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 373994003481 Peptidase family M23; Region: Peptidase_M23; pfam01551 373994003482 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 373994003483 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 373994003484 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 373994003485 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 373994003486 Dehydratase family; Region: ILVD_EDD; cl00340 373994003487 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 373994003488 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994003489 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994003490 active site 373994003491 ATP binding site [chemical binding]; other site 373994003492 substrate binding site [chemical binding]; other site 373994003493 activation loop (A-loop); other site 373994003494 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994003495 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994003496 active site 373994003497 ATP binding site [chemical binding]; other site 373994003498 substrate binding site [chemical binding]; other site 373994003499 activation loop (A-loop); other site 373994003500 Rubrerythrin [Energy production and conversion]; Region: COG1592 373994003501 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 373994003502 binuclear metal center [ion binding]; other site 373994003503 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 373994003504 iron binding site [ion binding]; other site 373994003505 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 373994003506 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 373994003507 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 373994003508 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 373994003509 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 373994003510 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 373994003511 catalytic residues [active] 373994003512 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 373994003513 phosphodiesterase; Provisional; Region: PRK12704 373994003514 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994003515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994003516 active site 373994003517 phosphorylation site [posttranslational modification] 373994003518 intermolecular recognition site; other site 373994003519 dimerization interface [polypeptide binding]; other site 373994003520 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994003521 DNA binding site [nucleotide binding] 373994003522 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 373994003523 PAS domain; Region: PAS; smart00091 373994003524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994003525 dimer interface [polypeptide binding]; other site 373994003526 phosphorylation site [posttranslational modification] 373994003527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994003528 ATP binding site [chemical binding]; other site 373994003529 Mg2+ binding site [ion binding]; other site 373994003530 G-X-G motif; other site 373994003531 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 373994003532 PhoU domain; Region: PhoU; pfam01895 373994003533 PhoU domain; Region: PhoU; pfam01895 373994003534 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 373994003535 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 373994003536 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 373994003537 ligand binding site [chemical binding]; other site 373994003538 flexible hinge region; other site 373994003539 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 373994003540 S-layer homology domain; Region: SLH; pfam00395 373994003541 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 373994003542 S-layer homology domain; Region: SLH; pfam00395 373994003543 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 373994003544 S-layer homology domain; Region: SLH; pfam00395 373994003545 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 373994003546 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 373994003547 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 373994003548 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 373994003549 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 373994003550 Ligand binding site; other site 373994003551 Putative Catalytic site; other site 373994003552 DXD motif; other site 373994003553 Predicted membrane protein [Function unknown]; Region: COG2246 373994003554 GtrA-like protein; Region: GtrA; pfam04138 373994003555 FO synthase subunit 2; Reviewed; Region: PRK07360 373994003556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994003557 FeS/SAM binding site; other site 373994003558 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 373994003559 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 373994003560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 373994003561 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 373994003562 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373994003563 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 373994003564 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 373994003565 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373994003566 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 373994003567 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 373994003568 catalytic residues [active] 373994003569 Predicted membrane protein [Function unknown]; Region: COG4094 373994003570 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 373994003571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994003572 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 373994003573 putative dimerization interface [polypeptide binding]; other site 373994003574 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994003575 active site 373994003576 ATP binding site [chemical binding]; other site 373994003577 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994003578 substrate binding site [chemical binding]; other site 373994003579 activation loop (A-loop); other site 373994003580 PBP superfamily domain; Region: PBP_like_2; pfam12849 373994003581 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994003582 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 373994003583 putative switch regulator; other site 373994003584 non-specific DNA interactions [nucleotide binding]; other site 373994003585 DNA binding site [nucleotide binding] 373994003586 sequence specific DNA binding site [nucleotide binding]; other site 373994003587 putative cAMP binding site [chemical binding]; other site 373994003588 tRNA binding surface [nucleotide binding]; other site 373994003589 DALR anticodon binding domain; Region: DALR_1; smart00836 373994003590 anticodon binding site; other site 373994003591 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 373994003592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994003593 active site 373994003594 motif I; other site 373994003595 motif II; other site 373994003596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994003597 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 373994003598 DNA polymerase I; Provisional; Region: PRK05755 373994003599 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 373994003600 active site 373994003601 metal binding site 1 [ion binding]; metal-binding site 373994003602 putative 5' ssDNA interaction site; other site 373994003603 metal binding site 3; metal-binding site 373994003604 metal binding site 2 [ion binding]; metal-binding site 373994003605 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 373994003606 putative DNA binding site [nucleotide binding]; other site 373994003607 putative metal binding site [ion binding]; other site 373994003608 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 373994003609 active site 373994003610 catalytic site [active] 373994003611 substrate binding site [chemical binding]; other site 373994003612 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 373994003613 active site 373994003614 DNA binding site [nucleotide binding] 373994003615 catalytic site [active] 373994003616 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 373994003617 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 373994003618 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 373994003619 carboxylate-amine ligase; Provisional; Region: PRK13515 373994003620 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 373994003621 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 373994003622 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 373994003623 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373994003624 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 373994003625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994003626 motif II; other site 373994003627 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 373994003628 recombination protein F; Reviewed; Region: recF; PRK00064 373994003629 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 373994003630 Walker A/P-loop; other site 373994003631 ATP binding site [chemical binding]; other site 373994003632 Q-loop/lid; other site 373994003633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994003634 ABC transporter signature motif; other site 373994003635 Walker B; other site 373994003636 D-loop; other site 373994003637 H-loop/switch region; other site 373994003638 phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418 373994003639 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 373994003640 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 373994003641 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 373994003642 Predicted membrane protein [Function unknown]; Region: COG4330 373994003643 S-layer homology domain; Region: SLH; pfam00395 373994003644 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 373994003645 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 373994003646 dimer interface [polypeptide binding]; other site 373994003647 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373994003648 metal binding site [ion binding]; metal-binding site 373994003649 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 373994003650 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 373994003651 Walker A/P-loop; other site 373994003652 ATP binding site [chemical binding]; other site 373994003653 Q-loop/lid; other site 373994003654 ABC transporter signature motif; other site 373994003655 Walker B; other site 373994003656 D-loop; other site 373994003657 H-loop/switch region; other site 373994003658 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 373994003659 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 373994003660 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 373994003661 PDGLE domain; Region: PDGLE; pfam13190 373994003662 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 373994003663 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 373994003664 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 373994003665 Ferritin-like domain; Region: Ferritin; pfam00210 373994003666 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 373994003667 dinuclear metal binding motif [ion binding]; other site 373994003668 Iron permease FTR1 family; Region: FTR1; cl00475 373994003669 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 373994003670 Ferritin-like domain; Region: Ferritin; pfam00210 373994003671 dinuclear metal binding motif [ion binding]; other site 373994003672 Inward rectifier potassium channel; Region: IRK; pfam01007 373994003673 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 373994003674 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 373994003675 active site residue [active] 373994003676 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 373994003677 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 373994003678 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 373994003679 trimer interface [polypeptide binding]; other site 373994003680 active site 373994003681 substrate binding site [chemical binding]; other site 373994003682 CoA binding site [chemical binding]; other site 373994003683 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 373994003684 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 373994003685 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 373994003686 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 373994003687 protein-splicing catalytic site; other site 373994003688 thioester formation/cholesterol transfer; other site 373994003689 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 373994003690 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 373994003691 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 373994003692 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 373994003693 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 373994003694 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 373994003695 AMP binding site [chemical binding]; other site 373994003696 metal binding site [ion binding]; metal-binding site 373994003697 active site 373994003698 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 373994003699 putative active site [active] 373994003700 transaldolase; Provisional; Region: PRK03903 373994003701 catalytic residue [active] 373994003702 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 373994003703 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 373994003704 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 373994003705 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994003706 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 373994003707 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 373994003708 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 373994003709 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 373994003710 catalytic triad [active] 373994003711 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994003712 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994003713 ligand binding site [chemical binding]; other site 373994003714 flexible hinge region; other site 373994003715 hypothetical protein; Reviewed; Region: PRK12275 373994003716 four helix bundle protein; Region: TIGR02436 373994003717 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 373994003718 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 373994003719 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 373994003720 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 373994003721 hydrolase, alpha/beta fold family protein; Region: PLN02824 373994003722 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 373994003723 putative hydrophobic ligand binding site [chemical binding]; other site 373994003724 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 373994003725 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 373994003726 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 373994003727 B12 binding site [chemical binding]; other site 373994003728 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994003729 FeS/SAM binding site; other site 373994003730 Uncharacterized conserved protein [Function unknown]; Region: COG4095 373994003731 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 373994003732 active site 373994003733 shikimate kinase; Reviewed; Region: aroK; PRK00131 373994003734 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 373994003735 active site 373994003736 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 373994003737 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 373994003738 Tetramer interface [polypeptide binding]; other site 373994003739 active site 373994003740 FMN-binding site [chemical binding]; other site 373994003741 short chain dehydrogenase; Provisional; Region: PRK06172 373994003742 classical (c) SDRs; Region: SDR_c; cd05233 373994003743 NAD(P) binding site [chemical binding]; other site 373994003744 active site 373994003745 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 373994003746 protein I interface; other site 373994003747 D2 interface; other site 373994003748 protein T interface; other site 373994003749 chlorophyll binding site; other site 373994003750 beta carotene binding site; other site 373994003751 pheophytin binding site; other site 373994003752 manganese-stabilizing polypeptide interface; other site 373994003753 CP43 interface; other site 373994003754 protein L interface; other site 373994003755 oxygen evolving complex binding site; other site 373994003756 bromide binding site; other site 373994003757 quinone binding site; other site 373994003758 Fe binding site [ion binding]; other site 373994003759 core light harvesting interface; other site 373994003760 cytochrome b559 alpha subunit interface; other site 373994003761 cytochrome c-550 interface; other site 373994003762 protein J interface; other site 373994003763 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 373994003764 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 373994003765 molybdopterin cofactor binding site; other site 373994003766 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 373994003767 molybdopterin cofactor binding site; other site 373994003768 CHAT domain; Region: CHAT; pfam12770 373994003769 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994003770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994003771 binding surface 373994003772 TPR motif; other site 373994003773 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994003774 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994003775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994003776 binding surface 373994003777 TPR motif; other site 373994003778 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994003779 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994003780 Tetratricopeptide repeat; Region: TPR_10; pfam13374 373994003781 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994003782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994003783 binding surface 373994003784 TPR motif; other site 373994003785 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994003786 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 373994003787 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 373994003788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994003789 non-specific DNA binding site [nucleotide binding]; other site 373994003790 salt bridge; other site 373994003791 sequence-specific DNA binding site [nucleotide binding]; other site 373994003792 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994003793 putative active site [active] 373994003794 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994003795 putative active site [active] 373994003796 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994003797 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994003798 lipoyl synthase; Provisional; Region: PRK05481 373994003799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994003800 FeS/SAM binding site; other site 373994003801 AAA ATPase domain; Region: AAA_16; pfam13191 373994003802 NACHT domain; Region: NACHT; pfam05729 373994003803 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994003804 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994003805 structural tetrad; other site 373994003806 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994003807 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994003808 structural tetrad; other site 373994003809 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 373994003810 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 373994003811 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 373994003812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 373994003813 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 373994003814 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994003815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 373994003816 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 373994003817 catalytic site [active] 373994003818 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 373994003819 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 373994003820 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 373994003821 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 373994003822 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 373994003823 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373994003824 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373994003825 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373994003826 DNA binding residues [nucleotide binding] 373994003827 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 373994003828 metal binding site 2 [ion binding]; metal-binding site 373994003829 putative DNA binding helix; other site 373994003830 metal binding site 1 [ion binding]; metal-binding site 373994003831 dimer interface [polypeptide binding]; other site 373994003832 structural Zn2+ binding site [ion binding]; other site 373994003833 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994003834 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994003835 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994003836 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994003837 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994003838 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994003839 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 373994003840 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 373994003841 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 373994003842 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994003843 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994003844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994003845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994003846 dimer interface [polypeptide binding]; other site 373994003847 phosphorylation site [posttranslational modification] 373994003848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994003849 ATP binding site [chemical binding]; other site 373994003850 Mg2+ binding site [ion binding]; other site 373994003851 G-X-G motif; other site 373994003852 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 373994003853 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 373994003854 active site 373994003855 homodimer interface [polypeptide binding]; other site 373994003856 catalytic site [active] 373994003857 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 373994003858 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 373994003859 L-aspartate oxidase; Provisional; Region: PRK06175 373994003860 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 373994003861 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 373994003862 Domain of unknown function DUF39; Region: DUF39; pfam01837 373994003863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994003864 TPR motif; other site 373994003865 binding surface 373994003866 TPR repeat; Region: TPR_11; pfam13414 373994003867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994003868 TPR motif; other site 373994003869 Predicted membrane protein [Function unknown]; Region: COG2119 373994003870 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 373994003871 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 373994003872 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 373994003873 Domain of unknown function DUF20; Region: UPF0118; pfam01594 373994003874 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 373994003875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994003876 Walker A motif; other site 373994003877 ATP binding site [chemical binding]; other site 373994003878 Walker B motif; other site 373994003879 arginine finger; other site 373994003880 Peptidase family M41; Region: Peptidase_M41; pfam01434 373994003881 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 373994003882 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 373994003883 homodimer interface [polypeptide binding]; other site 373994003884 active site 373994003885 TDP-binding site; other site 373994003886 acceptor substrate-binding pocket; other site 373994003887 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994003888 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994003889 structural tetrad; other site 373994003890 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 373994003891 NADH(P)-binding; Region: NAD_binding_10; pfam13460 373994003892 NAD(P) binding site [chemical binding]; other site 373994003893 putative active site [active] 373994003894 aspartate aminotransferase; Provisional; Region: PRK05957 373994003895 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373994003896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994003897 homodimer interface [polypeptide binding]; other site 373994003898 catalytic residue [active] 373994003899 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 373994003900 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994003901 active site 373994003902 ATP binding site [chemical binding]; other site 373994003903 substrate binding site [chemical binding]; other site 373994003904 activation loop (A-loop); other site 373994003905 Peptidase family M48; Region: Peptidase_M48; pfam01435 373994003906 Circadian oscillating protein COP23; Region: COP23; pfam14218 373994003907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 373994003908 DEAD-like helicases superfamily; Region: DEXDc; smart00487 373994003909 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994003910 ATP binding site [chemical binding]; other site 373994003911 putative Mg++ binding site [ion binding]; other site 373994003912 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994003913 ATP-binding site [chemical binding]; other site 373994003914 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 373994003915 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 373994003916 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 373994003917 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 373994003918 intersubunit interface [polypeptide binding]; other site 373994003919 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 373994003920 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994003921 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 373994003922 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 373994003923 active site 373994003924 interdomain interaction site; other site 373994003925 putative metal-binding site [ion binding]; other site 373994003926 nucleotide binding site [chemical binding]; other site 373994003927 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 373994003928 domain I; other site 373994003929 DNA binding groove [nucleotide binding] 373994003930 phosphate binding site [ion binding]; other site 373994003931 domain II; other site 373994003932 domain III; other site 373994003933 nucleotide binding site [chemical binding]; other site 373994003934 catalytic site [active] 373994003935 domain IV; other site 373994003936 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 373994003937 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 373994003938 active site 373994003939 homodimer interface [polypeptide binding]; other site 373994003940 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994003941 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994003942 active site 373994003943 ATP binding site [chemical binding]; other site 373994003944 substrate binding site [chemical binding]; other site 373994003945 activation loop (A-loop); other site 373994003946 AAA ATPase domain; Region: AAA_16; pfam13191 373994003947 Predicted ATPase [General function prediction only]; Region: COG3899 373994003948 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994003949 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994003950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994003951 ATP binding site [chemical binding]; other site 373994003952 Mg2+ binding site [ion binding]; other site 373994003953 G-X-G motif; other site 373994003954 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 373994003955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 373994003956 glycogen synthase; Provisional; Region: glgA; PRK00654 373994003957 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 373994003958 ADP-binding pocket [chemical binding]; other site 373994003959 homodimer interface [polypeptide binding]; other site 373994003960 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 373994003961 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 373994003962 active site 373994003963 domain interfaces; other site 373994003964 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994003965 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373994003966 active site 373994003967 metal binding site [ion binding]; metal-binding site 373994003968 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 373994003969 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994003970 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 373994003971 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994003972 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994003973 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994003974 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994003975 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994003976 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994003977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994003978 TPR repeat; Region: TPR_11; pfam13414 373994003979 TPR motif; other site 373994003980 binding surface 373994003981 Putative transcription activator [Transcription]; Region: TenA; COG0819 373994003982 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373994003983 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 373994003984 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 373994003985 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994003986 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994003987 ligand binding site [chemical binding]; other site 373994003988 flexible hinge region; other site 373994003989 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 373994003990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 373994003991 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 373994003992 4Fe-4S binding domain; Region: Fer4_5; pfam12801 373994003993 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 373994003994 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 373994003995 inhibitor-cofactor binding pocket; inhibition site 373994003996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994003997 catalytic residue [active] 373994003998 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994003999 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994004000 active site 373994004001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 373994004002 TrkA-N domain; Region: TrkA_N; pfam02254 373994004003 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 373994004004 TrkA-N domain; Region: TrkA_N; pfam02254 373994004005 PAS domain S-box; Region: sensory_box; TIGR00229 373994004006 PAS domain S-box; Region: sensory_box; TIGR00229 373994004007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994004008 putative active site [active] 373994004009 heme pocket [chemical binding]; other site 373994004010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994004011 PAS domain; Region: PAS_9; pfam13426 373994004012 putative active site [active] 373994004013 heme pocket [chemical binding]; other site 373994004014 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 373994004015 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 373994004016 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 373994004017 Walker A/P-loop; other site 373994004018 ATP binding site [chemical binding]; other site 373994004019 Q-loop/lid; other site 373994004020 ABC transporter signature motif; other site 373994004021 Walker B; other site 373994004022 D-loop; other site 373994004023 H-loop/switch region; other site 373994004024 DevC protein; Region: devC; TIGR01185 373994004025 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994004026 FtsX-like permease family; Region: FtsX; pfam02687 373994004027 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 373994004028 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994004029 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994004030 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 373994004031 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994004032 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 373994004033 structural tetrad; other site 373994004034 PemK-like protein; Region: PemK; pfam02452 373994004035 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 373994004036 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 373994004037 Walker A/P-loop; other site 373994004038 ATP binding site [chemical binding]; other site 373994004039 Q-loop/lid; other site 373994004040 ABC transporter signature motif; other site 373994004041 Walker B; other site 373994004042 D-loop; other site 373994004043 H-loop/switch region; other site 373994004044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994004045 TPR motif; other site 373994004046 binding surface 373994004047 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 373994004048 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 373994004049 nudix motif; other site 373994004050 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 373994004051 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 373994004052 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 373994004053 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 373994004054 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994004055 FeS/SAM binding site; other site 373994004056 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 373994004057 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373994004058 Zn2+ binding site [ion binding]; other site 373994004059 Mg2+ binding site [ion binding]; other site 373994004060 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994004061 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994004062 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994004063 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994004064 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994004065 KWG Leptospira; Region: KWG; pfam07656 373994004066 KWG Leptospira; Region: KWG; pfam07656 373994004067 KWG Leptospira; Region: KWG; pfam07656 373994004068 KWG Leptospira; Region: KWG; pfam07656 373994004069 CAAX protease self-immunity; Region: Abi; pfam02517 373994004070 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 373994004071 FHA domain; Region: FHA; pfam00498 373994004072 phosphopeptide binding site; other site 373994004073 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 373994004074 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994004075 phosphopeptide binding site; other site 373994004076 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 373994004077 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 373994004078 Walker A/P-loop; other site 373994004079 ATP binding site [chemical binding]; other site 373994004080 Q-loop/lid; other site 373994004081 ABC transporter signature motif; other site 373994004082 Walker B; other site 373994004083 D-loop; other site 373994004084 H-loop/switch region; other site 373994004085 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 373994004086 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 373994004087 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994004088 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994004089 active site 373994004090 ATP binding site [chemical binding]; other site 373994004091 substrate binding site [chemical binding]; other site 373994004092 activation loop (A-loop); other site 373994004093 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 373994004094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994004095 dimerization interface [polypeptide binding]; other site 373994004096 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994004097 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994004098 active site 373994004099 ATP binding site [chemical binding]; other site 373994004100 substrate binding site [chemical binding]; other site 373994004101 activation loop (A-loop); other site 373994004102 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994004103 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994004104 structural tetrad; other site 373994004105 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 373994004106 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 373994004107 active site 373994004108 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994004109 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994004110 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994004111 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994004112 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 373994004113 ribosome maturation protein RimP; Reviewed; Region: PRK00092 373994004114 Sm and related proteins; Region: Sm_like; cl00259 373994004115 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 373994004116 putative oligomer interface [polypeptide binding]; other site 373994004117 putative RNA binding site [nucleotide binding]; other site 373994004118 NusA N-terminal domain; Region: NusA_N; pfam08529 373994004119 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 373994004120 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 373994004121 RNA binding site [nucleotide binding]; other site 373994004122 homodimer interface [polypeptide binding]; other site 373994004123 NusA-like KH domain; Region: KH_5; pfam13184 373994004124 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 373994004125 G-X-X-G motif; other site 373994004126 Protein of unknown function (DUF448); Region: DUF448; pfam04296 373994004127 putative RNA binding cleft [nucleotide binding]; other site 373994004128 AF-4 proto-oncoprotein; Region: AF-4; pfam05110 373994004129 translation initiation factor IF-2; Region: IF-2; TIGR00487 373994004130 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 373994004131 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 373994004132 G1 box; other site 373994004133 putative GEF interaction site [polypeptide binding]; other site 373994004134 GTP/Mg2+ binding site [chemical binding]; other site 373994004135 Switch I region; other site 373994004136 G2 box; other site 373994004137 G3 box; other site 373994004138 Switch II region; other site 373994004139 G4 box; other site 373994004140 G5 box; other site 373994004141 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 373994004142 Translation-initiation factor 2; Region: IF-2; pfam11987 373994004143 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 373994004144 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 373994004145 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 373994004146 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 373994004147 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 373994004148 active site 373994004149 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 373994004150 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 373994004151 dimer interface [polypeptide binding]; other site 373994004152 putative anticodon binding site; other site 373994004153 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 373994004154 motif 1; other site 373994004155 active site 373994004156 motif 2; other site 373994004157 motif 3; other site 373994004158 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 373994004159 active site 373994004160 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 373994004161 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994004162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994004163 binding surface 373994004164 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994004165 TPR motif; other site 373994004166 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994004167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994004168 binding surface 373994004169 TPR motif; other site 373994004170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994004171 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 373994004172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994004173 dimer interface [polypeptide binding]; other site 373994004174 phosphorylation site [posttranslational modification] 373994004175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994004176 ATP binding site [chemical binding]; other site 373994004177 Mg2+ binding site [ion binding]; other site 373994004178 G-X-G motif; other site 373994004179 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 373994004180 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 373994004181 polyphosphate kinase; Provisional; Region: PRK05443 373994004182 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 373994004183 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 373994004184 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 373994004185 putative domain interface [polypeptide binding]; other site 373994004186 putative active site [active] 373994004187 catalytic site [active] 373994004188 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 373994004189 putative domain interface [polypeptide binding]; other site 373994004190 putative active site [active] 373994004191 catalytic site [active] 373994004192 Response regulator receiver domain; Region: Response_reg; pfam00072 373994004193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994004194 active site 373994004195 phosphorylation site [posttranslational modification] 373994004196 intermolecular recognition site; other site 373994004197 dimerization interface [polypeptide binding]; other site 373994004198 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 373994004199 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 373994004200 Response regulator receiver domain; Region: Response_reg; pfam00072 373994004201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994004202 active site 373994004203 phosphorylation site [posttranslational modification] 373994004204 intermolecular recognition site; other site 373994004205 dimerization interface [polypeptide binding]; other site 373994004206 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373994004207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373994004208 metal binding site [ion binding]; metal-binding site 373994004209 active site 373994004210 I-site; other site 373994004211 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 373994004212 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 373994004213 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 373994004214 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 373994004215 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 373994004216 ribosomal protein S14; Region: rps14; CHL00074 373994004217 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 373994004218 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 373994004219 minor groove reading motif; other site 373994004220 helix-hairpin-helix signature motif; other site 373994004221 substrate binding pocket [chemical binding]; other site 373994004222 active site 373994004223 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 373994004224 Peptidase family M50; Region: Peptidase_M50; pfam02163 373994004225 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 373994004226 active site 373994004227 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 373994004228 protein binding site [polypeptide binding]; other site 373994004229 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 373994004230 putative substrate binding region [chemical binding]; other site 373994004231 seryl-tRNA synthetase; Provisional; Region: PRK05431 373994004232 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 373994004233 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 373994004234 dimer interface [polypeptide binding]; other site 373994004235 active site 373994004236 motif 1; other site 373994004237 motif 2; other site 373994004238 motif 3; other site 373994004239 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 373994004240 Predicted transcriptional regulators [Transcription]; Region: COG1695 373994004241 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 373994004242 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 373994004243 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 373994004244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994004245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994004246 dimer interface [polypeptide binding]; other site 373994004247 phosphorylation site [posttranslational modification] 373994004248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994004249 ATP binding site [chemical binding]; other site 373994004250 Mg2+ binding site [ion binding]; other site 373994004251 G-X-G motif; other site 373994004252 S-layer homology domain; Region: SLH; pfam00395 373994004253 S-layer homology domain; Region: SLH; pfam00395 373994004254 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 373994004255 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 373994004256 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 373994004257 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 373994004258 active site 373994004259 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 373994004260 dimer interface [polypeptide binding]; other site 373994004261 ADP-ribose binding site [chemical binding]; other site 373994004262 active site 373994004263 nudix motif; other site 373994004264 metal binding site [ion binding]; metal-binding site 373994004265 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 373994004266 active site 373994004267 dimerization interface [polypeptide binding]; other site 373994004268 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 373994004269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 373994004270 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 373994004271 cytosine deaminase; Provisional; Region: PRK09230 373994004272 active site 373994004273 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 373994004274 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373994004275 substrate binding site [chemical binding]; other site 373994004276 dimer interface [polypeptide binding]; other site 373994004277 ATP binding site [chemical binding]; other site 373994004278 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 373994004279 active site 373994004280 nucleophile elbow; other site 373994004281 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 373994004282 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 373994004283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994004284 Walker A/P-loop; other site 373994004285 ATP binding site [chemical binding]; other site 373994004286 Q-loop/lid; other site 373994004287 ABC transporter signature motif; other site 373994004288 Walker B; other site 373994004289 D-loop; other site 373994004290 H-loop/switch region; other site 373994004291 TOBE domain; Region: TOBE_2; pfam08402 373994004292 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373994004293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994004294 ABC-ATPase subunit interface; other site 373994004295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994004296 dimer interface [polypeptide binding]; other site 373994004297 conserved gate region; other site 373994004298 putative PBP binding loops; other site 373994004299 ABC-ATPase subunit interface; other site 373994004300 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373994004301 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 373994004302 PAS fold; Region: PAS; pfam00989 373994004303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994004304 putative active site [active] 373994004305 heme pocket [chemical binding]; other site 373994004306 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373994004307 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373994004308 metal binding site [ion binding]; metal-binding site 373994004309 active site 373994004310 I-site; other site 373994004311 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 373994004312 homooctamer interface [polypeptide binding]; other site 373994004313 active site 373994004314 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 373994004315 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 373994004316 dimer interface [polypeptide binding]; other site 373994004317 tetramer interface [polypeptide binding]; other site 373994004318 PYR/PP interface [polypeptide binding]; other site 373994004319 TPP binding site [chemical binding]; other site 373994004320 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 373994004321 TPP-binding site; other site 373994004322 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 373994004323 Na binding site [ion binding]; other site 373994004324 SET domain; Region: SET; pfam00856 373994004325 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 373994004326 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 373994004327 substrate binding site [chemical binding]; other site 373994004328 oxyanion hole (OAH) forming residues; other site 373994004329 trimer interface [polypeptide binding]; other site 373994004330 Protein of unknown function (DUF721); Region: DUF721; cl02324 373994004331 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 373994004332 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 373994004333 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 373994004334 catalytic residues [active] 373994004335 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 373994004336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373994004337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994004338 homodimer interface [polypeptide binding]; other site 373994004339 catalytic residue [active] 373994004340 Response regulator receiver domain; Region: Response_reg; pfam00072 373994004341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994004342 active site 373994004343 phosphorylation site [posttranslational modification] 373994004344 intermolecular recognition site; other site 373994004345 dimerization interface [polypeptide binding]; other site 373994004346 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 373994004347 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 373994004348 GIY-YIG motif/motif A; other site 373994004349 active site 373994004350 catalytic site [active] 373994004351 putative DNA binding site [nucleotide binding]; other site 373994004352 metal binding site [ion binding]; metal-binding site 373994004353 UvrB/uvrC motif; Region: UVR; pfam02151 373994004354 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 373994004355 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 373994004356 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 373994004357 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994004358 Probable transposase; Region: OrfB_IS605; pfam01385 373994004359 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 373994004360 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 373994004361 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 373994004362 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 373994004363 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 373994004364 Walker A/P-loop; other site 373994004365 ATP binding site [chemical binding]; other site 373994004366 Q-loop/lid; other site 373994004367 ABC transporter signature motif; other site 373994004368 Walker B; other site 373994004369 D-loop; other site 373994004370 H-loop/switch region; other site 373994004371 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994004372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994004373 active site 373994004374 phosphorylation site [posttranslational modification] 373994004375 intermolecular recognition site; other site 373994004376 dimerization interface [polypeptide binding]; other site 373994004377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994004378 DNA binding site [nucleotide binding] 373994004379 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 373994004380 putative GSH binding site [chemical binding]; other site 373994004381 catalytic residues [active] 373994004382 BolA-like protein; Region: BolA; pfam01722 373994004383 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 373994004384 active site 373994004385 catalytic triad [active] 373994004386 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 373994004387 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 373994004388 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 373994004389 putative acyl-acceptor binding pocket; other site 373994004390 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 373994004391 nucleoside/Zn binding site; other site 373994004392 dimer interface [polypeptide binding]; other site 373994004393 catalytic motif [active] 373994004394 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 373994004395 GSH binding site [chemical binding]; other site 373994004396 catalytic residues [active] 373994004397 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 373994004398 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 373994004399 putative active site [active] 373994004400 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 373994004401 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 373994004402 tRNA; other site 373994004403 putative tRNA binding site [nucleotide binding]; other site 373994004404 putative NADP binding site [chemical binding]; other site 373994004405 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 373994004406 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 373994004407 hypothetical protein; Provisional; Region: PRK02509 373994004408 Uncharacterized conserved protein [Function unknown]; Region: COG1615 373994004409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373994004410 dimerization interface [polypeptide binding]; other site 373994004411 putative DNA binding site [nucleotide binding]; other site 373994004412 putative Zn2+ binding site [ion binding]; other site 373994004413 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 373994004414 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 373994004415 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 373994004416 Cytochrome P450; Region: p450; cl12078 373994004417 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994004418 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 373994004419 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 373994004420 active site 373994004421 dimer interface [polypeptide binding]; other site 373994004422 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 373994004423 dimer interface [polypeptide binding]; other site 373994004424 active site 373994004425 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 373994004426 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 373994004427 SnoaL-like domain; Region: SnoaL_2; pfam12680 373994004428 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 373994004429 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 373994004430 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 373994004431 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 373994004432 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 373994004433 DNA binding site [nucleotide binding] 373994004434 catalytic residue [active] 373994004435 H2TH interface [polypeptide binding]; other site 373994004436 putative catalytic residues [active] 373994004437 turnover-facilitating residue; other site 373994004438 intercalation triad [nucleotide binding]; other site 373994004439 8OG recognition residue [nucleotide binding]; other site 373994004440 putative reading head residues; other site 373994004441 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 373994004442 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 373994004443 photosystem I subunit IV; Reviewed; Region: psaE; CHL00125 373994004444 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 373994004445 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 373994004446 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 373994004447 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 373994004448 Mg++ binding site [ion binding]; other site 373994004449 putative catalytic motif [active] 373994004450 putative substrate binding site [chemical binding]; other site 373994004451 Psb28 protein; Region: Psb28; cl04326 373994004452 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 373994004453 putative active site [active] 373994004454 dimerization interface [polypeptide binding]; other site 373994004455 putative tRNAtyr binding site [nucleotide binding]; other site 373994004456 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 373994004457 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994004458 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 373994004459 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 373994004460 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 373994004461 active site 373994004462 HIGH motif; other site 373994004463 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 373994004464 KMSKS motif; other site 373994004465 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 373994004466 tRNA binding surface [nucleotide binding]; other site 373994004467 anticodon binding site; other site 373994004468 Domain of unknown function DUF20; Region: UPF0118; pfam01594 373994004469 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 373994004470 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 373994004471 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 373994004472 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 373994004473 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 373994004474 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 373994004475 active site 373994004476 (T/H)XGH motif; other site 373994004477 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 373994004478 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 373994004479 Ligand Binding Site [chemical binding]; other site 373994004480 Molecular Tunnel; other site 373994004481 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 373994004482 active site 373994004483 metal binding site [ion binding]; metal-binding site 373994004484 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 373994004485 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 373994004486 active site 373994004487 metal binding site [ion binding]; metal-binding site 373994004488 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 373994004489 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 373994004490 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373994004491 catalytic residue [active] 373994004492 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994004493 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994004494 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994004495 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994004496 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 373994004497 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 373994004498 Ligand Binding Site [chemical binding]; other site 373994004499 Molecular Tunnel; other site 373994004500 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 373994004501 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 373994004502 active site 373994004503 SAM binding site [chemical binding]; other site 373994004504 homodimer interface [polypeptide binding]; other site 373994004505 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 373994004506 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 373994004507 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 373994004508 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 373994004509 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994004510 FeS/SAM binding site; other site 373994004511 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 373994004512 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 373994004513 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 373994004514 Na binding site [ion binding]; other site 373994004515 GTPase Era; Reviewed; Region: era; PRK00089 373994004516 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 373994004517 G1 box; other site 373994004518 GTP/Mg2+ binding site [chemical binding]; other site 373994004519 Switch I region; other site 373994004520 G2 box; other site 373994004521 Switch II region; other site 373994004522 G3 box; other site 373994004523 G4 box; other site 373994004524 G5 box; other site 373994004525 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 373994004526 active site 373994004527 Zn binding site [ion binding]; other site 373994004528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 373994004529 Probable transposase; Region: OrfB_IS605; pfam01385 373994004530 Maf-like protein; Region: Maf; pfam02545 373994004531 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 373994004532 active site 373994004533 dimer interface [polypeptide binding]; other site 373994004534 PsbP; Region: PsbP; pfam01789 373994004535 Uncharacterized conserved protein [Function unknown]; Region: COG5634 373994004536 Lamin Tail Domain; Region: LTD; pfam00932 373994004537 GAF domain; Region: GAF_3; pfam13492 373994004538 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 373994004539 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 373994004540 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 373994004541 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 373994004542 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 373994004543 P loop; other site 373994004544 GTP binding site [chemical binding]; other site 373994004545 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 373994004546 putative RNA binding site [nucleotide binding]; other site 373994004547 Uncharacterized conserved protein [Function unknown]; Region: COG2928 373994004548 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 373994004549 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994004550 putative metal binding site; other site 373994004551 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 373994004552 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994004553 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994004554 active site 373994004555 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 373994004556 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 373994004557 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 373994004558 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 373994004559 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 373994004560 heat shock protein 90; Provisional; Region: PRK05218 373994004561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994004562 ATP binding site [chemical binding]; other site 373994004563 Mg2+ binding site [ion binding]; other site 373994004564 G-X-G motif; other site 373994004565 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994004566 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994004567 active site 373994004568 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994004569 active site 373994004570 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994004571 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994004572 active site 373994004573 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994004574 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994004575 active site 373994004576 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994004577 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 373994004578 Clp amino terminal domain; Region: Clp_N; pfam02861 373994004579 Clp amino terminal domain; Region: Clp_N; pfam02861 373994004580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994004581 Walker A motif; other site 373994004582 ATP binding site [chemical binding]; other site 373994004583 Walker B motif; other site 373994004584 arginine finger; other site 373994004585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994004586 Walker A motif; other site 373994004587 ATP binding site [chemical binding]; other site 373994004588 Walker B motif; other site 373994004589 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 373994004590 S-layer homology domain; Region: SLH; pfam00395 373994004591 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 373994004592 enolase; Provisional; Region: eno; PRK00077 373994004593 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 373994004594 dimer interface [polypeptide binding]; other site 373994004595 metal binding site [ion binding]; metal-binding site 373994004596 substrate binding pocket [chemical binding]; other site 373994004597 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 373994004598 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 373994004599 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 373994004600 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 373994004601 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 373994004602 dimerization interface [polypeptide binding]; other site 373994004603 active site 373994004604 AAA domain; Region: AAA_21; pfam13304 373994004605 RloB-like protein; Region: RloB; pfam13707 373994004606 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 373994004607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994004608 non-specific DNA binding site [nucleotide binding]; other site 373994004609 salt bridge; other site 373994004610 sequence-specific DNA binding site [nucleotide binding]; other site 373994004611 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 373994004612 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 373994004613 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 373994004614 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 373994004615 substrate binding pocket [chemical binding]; other site 373994004616 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 373994004617 B12 binding site [chemical binding]; other site 373994004618 cobalt ligand [ion binding]; other site 373994004619 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 373994004620 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 373994004621 putative active site [active] 373994004622 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994004623 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 373994004624 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 373994004625 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 373994004626 catalytic motif [active] 373994004627 Zn binding site [ion binding]; other site 373994004628 RibD C-terminal domain; Region: RibD_C; cl17279 373994004629 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 373994004630 rod shape-determining protein MreC; Provisional; Region: PRK13922 373994004631 rod shape-determining protein MreC; Region: MreC; pfam04085 373994004632 rod shape-determining protein MreB; Provisional; Region: PRK13927 373994004633 MreB and similar proteins; Region: MreB_like; cd10225 373994004634 nucleotide binding site [chemical binding]; other site 373994004635 Mg binding site [ion binding]; other site 373994004636 putative protofilament interaction site [polypeptide binding]; other site 373994004637 RodZ interaction site [polypeptide binding]; other site 373994004638 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 373994004639 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 373994004640 dimer interface [polypeptide binding]; other site 373994004641 ssDNA binding site [nucleotide binding]; other site 373994004642 tetramer (dimer of dimers) interface [polypeptide binding]; other site 373994004643 Uncharacterized conserved protein [Function unknown]; Region: COG2968 373994004644 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 373994004645 EVE domain; Region: EVE; pfam01878 373994004646 AMIN domain; Region: AMIN; pfam11741 373994004647 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 373994004648 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373994004649 active site 373994004650 metal binding site [ion binding]; metal-binding site 373994004651 AMIN domain; Region: AMIN; pfam11741 373994004652 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 373994004653 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373994004654 active site 373994004655 metal binding site [ion binding]; metal-binding site 373994004656 glutamate racemase; Provisional; Region: PRK00865 373994004657 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 373994004658 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 373994004659 substrate binding pocket [chemical binding]; other site 373994004660 chain length determination region; other site 373994004661 substrate-Mg2+ binding site; other site 373994004662 catalytic residues [active] 373994004663 aspartate-rich region 1; other site 373994004664 active site lid residues [active] 373994004665 aspartate-rich region 2; other site 373994004666 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 373994004667 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 373994004668 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 373994004669 hypothetical protein; Provisional; Region: PRK04323 373994004670 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 373994004671 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 373994004672 catalytic site [active] 373994004673 G-X2-G-X-G-K; other site 373994004674 Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605 373994004675 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 373994004676 Photosystem I reaction centre subunit III; Region: PSI_PsaF; pfam02507 373994004677 UGMP family protein; Validated; Region: PRK09604 373994004678 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 373994004679 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994004680 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 373994004681 catalytic site [active] 373994004682 Fragile site-associated protein C-terminus; Region: FSA_C; pfam10479 373994004683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994004684 Coenzyme A binding pocket [chemical binding]; other site 373994004685 Tic22-like family; Region: Tic22; cl04468 373994004686 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 373994004687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994004688 S-adenosylmethionine binding site [chemical binding]; other site 373994004689 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 373994004690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994004691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994004692 dimer interface [polypeptide binding]; other site 373994004693 phosphorylation site [posttranslational modification] 373994004694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 373994004695 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 373994004696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994004697 Coenzyme A binding pocket [chemical binding]; other site 373994004698 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 373994004699 Protein export membrane protein; Region: SecD_SecF; pfam02355 373994004700 protein-export membrane protein SecD; Region: secD; TIGR01129 373994004701 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 373994004702 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 373994004703 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 373994004704 alpha subunit interface [polypeptide binding]; other site 373994004705 TPP binding site [chemical binding]; other site 373994004706 heterodimer interface [polypeptide binding]; other site 373994004707 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 373994004708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994004709 salt bridge; other site 373994004710 non-specific DNA binding site [nucleotide binding]; other site 373994004711 sequence-specific DNA binding site [nucleotide binding]; other site 373994004712 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 373994004713 dimer interface [polypeptide binding]; other site 373994004714 active site 373994004715 Schiff base residues; other site 373994004716 Tic20-like protein; Region: Tic20; pfam09685 373994004717 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 373994004718 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 373994004719 G1 box; other site 373994004720 putative GEF interaction site [polypeptide binding]; other site 373994004721 GTP/Mg2+ binding site [chemical binding]; other site 373994004722 Switch I region; other site 373994004723 G2 box; other site 373994004724 G3 box; other site 373994004725 Switch II region; other site 373994004726 G4 box; other site 373994004727 G5 box; other site 373994004728 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 373994004729 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 373994004730 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 373994004731 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 373994004732 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 373994004733 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 373994004734 putative ADP-binding pocket [chemical binding]; other site 373994004735 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 373994004736 Domain of unknown function (DUF814); Region: DUF814; pfam05670 373994004737 Cation efflux family; Region: Cation_efflux; cl00316 373994004738 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 373994004739 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994004740 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994004741 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994004742 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994004743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994004744 S-adenosylmethionine binding site [chemical binding]; other site 373994004745 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 373994004746 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 373994004747 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373994004748 catalytic residue [active] 373994004749 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 373994004750 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994004751 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 373994004752 short chain dehydrogenase; Provisional; Region: PRK06181 373994004753 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 373994004754 putative NAD(P) binding site [chemical binding]; other site 373994004755 homotetramer interface [polypeptide binding]; other site 373994004756 active site 373994004757 homodimer interface [polypeptide binding]; other site 373994004758 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 373994004759 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 373994004760 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 373994004761 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 373994004762 substrate-cofactor binding pocket; other site 373994004763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994004764 catalytic residue [active] 373994004765 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 373994004766 Fatty acid desaturase; Region: FA_desaturase; pfam00487 373994004767 Di-iron ligands [ion binding]; other site 373994004768 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 373994004769 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 373994004770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994004771 S-adenosylmethionine binding site [chemical binding]; other site 373994004772 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994004773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994004774 S-adenosylmethionine binding site [chemical binding]; other site 373994004775 acyl-CoA synthetase; Validated; Region: PRK05850 373994004776 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 373994004777 acyl-activating enzyme (AAE) consensus motif; other site 373994004778 active site 373994004779 H+ Antiporter protein; Region: 2A0121; TIGR00900 373994004780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994004781 putative substrate translocation pore; other site 373994004782 AAA ATPase domain; Region: AAA_16; pfam13191 373994004783 NB-ARC domain; Region: NB-ARC; pfam00931 373994004784 WD domain, G-beta repeat; Region: WD40; pfam00400 373994004785 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994004786 structural tetrad; other site 373994004787 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994004788 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994004789 structural tetrad; other site 373994004790 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 373994004791 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 373994004792 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 373994004793 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 373994004794 NAD binding site [chemical binding]; other site 373994004795 Phe binding site; other site 373994004796 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 373994004797 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 373994004798 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 373994004799 NAD(P) binding site [chemical binding]; other site 373994004800 catalytic residues [active] 373994004801 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 373994004802 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 373994004803 active site 373994004804 catalytic residues [active] 373994004805 metal binding site [ion binding]; metal-binding site 373994004806 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 373994004807 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 373994004808 substrate binding site [chemical binding]; other site 373994004809 ligand binding site [chemical binding]; other site 373994004810 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 373994004811 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 373994004812 substrate binding site [chemical binding]; other site 373994004813 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 373994004814 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 373994004815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994004816 S-adenosylmethionine binding site [chemical binding]; other site 373994004817 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373994004818 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 373994004819 anthranilate synthase; Provisional; Region: PRK13566 373994004820 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 373994004821 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 373994004822 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 373994004823 glutamine binding [chemical binding]; other site 373994004824 catalytic triad [active] 373994004825 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 373994004826 active site 373994004827 ribulose/triose binding site [chemical binding]; other site 373994004828 phosphate binding site [ion binding]; other site 373994004829 substrate (anthranilate) binding pocket [chemical binding]; other site 373994004830 product (indole) binding pocket [chemical binding]; other site 373994004831 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 373994004832 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 373994004833 substrate binding site [chemical binding]; other site 373994004834 active site 373994004835 catalytic residues [active] 373994004836 heterodimer interface [polypeptide binding]; other site 373994004837 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 373994004838 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 373994004839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994004840 catalytic residue [active] 373994004841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994004842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994004843 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 373994004844 Ca2+ binding site [ion binding]; other site 373994004845 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 373994004846 Ca2+ binding site [ion binding]; other site 373994004847 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 373994004848 Ca2+ binding site [ion binding]; other site 373994004849 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 373994004850 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 373994004851 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 373994004852 RHS Repeat; Region: RHS_repeat; pfam05593 373994004853 RHS Repeat; Region: RHS_repeat; pfam05593 373994004854 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 373994004855 RHS Repeat; Region: RHS_repeat; pfam05593 373994004856 RHS Repeat; Region: RHS_repeat; pfam05593 373994004857 RHS Repeat; Region: RHS_repeat; pfam05593 373994004858 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 373994004859 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 373994004860 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 373994004861 RHS Repeat; Region: RHS_repeat; pfam05593 373994004862 RHS Repeat; Region: RHS_repeat; pfam05593 373994004863 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 373994004864 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 373994004865 RHS Repeat; Region: RHS_repeat; pfam05593 373994004866 RHS Repeat; Region: RHS_repeat; pfam05593 373994004867 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 373994004868 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 373994004869 CHAT domain; Region: CHAT; cl17868 373994004870 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994004871 CHASE2 domain; Region: CHASE2; pfam05226 373994004872 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994004873 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 373994004874 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 373994004875 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994004876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994004877 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994004878 TPR motif; other site 373994004879 CHAT domain; Region: CHAT; cl17868 373994004880 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 373994004881 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 373994004882 Surface antigen; Region: Bac_surface_Ag; pfam01103 373994004883 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994004884 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994004885 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994004886 phage tail protein domain; Region: tail_TIGR02242 373994004887 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 373994004888 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 373994004889 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 373994004890 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 373994004891 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 373994004892 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 373994004893 Phage protein D [General function prediction only]; Region: COG3500 373994004894 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 373994004895 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 373994004896 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 373994004897 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 373994004898 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 373994004899 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 373994004900 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 373994004901 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 373994004902 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 373994004903 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 373994004904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994004905 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 373994004906 Walker A motif; other site 373994004907 ATP binding site [chemical binding]; other site 373994004908 Walker B motif; other site 373994004909 arginine finger; other site 373994004910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994004911 non-specific DNA binding site [nucleotide binding]; other site 373994004912 salt bridge; other site 373994004913 sequence-specific DNA binding site [nucleotide binding]; other site 373994004914 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 373994004915 Uncharacterized conserved protein [Function unknown]; Region: COG5464 373994004916 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 373994004917 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 373994004918 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 373994004919 active site 373994004920 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 373994004921 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 373994004922 active site 373994004923 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 373994004924 replicative DNA helicase; Region: DnaB; TIGR00665 373994004925 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 373994004926 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 373994004927 Walker A motif; other site 373994004928 ATP binding site [chemical binding]; other site 373994004929 Walker B motif; other site 373994004930 DNA binding loops [nucleotide binding] 373994004931 AAA-like domain; Region: AAA_10; pfam12846 373994004932 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 373994004933 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 373994004934 Ycf46; Provisional; Region: ycf46; CHL00195 373994004935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994004936 Walker A motif; other site 373994004937 ATP binding site [chemical binding]; other site 373994004938 Walker B motif; other site 373994004939 arginine finger; other site 373994004940 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 373994004941 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 373994004942 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 373994004943 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 373994004944 Mg binding site [ion binding]; other site 373994004945 nucleotide binding site [chemical binding]; other site 373994004946 putative protofilament interface [polypeptide binding]; other site 373994004947 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 373994004948 MarR family; Region: MarR_2; pfam12802 373994004949 Transcriptional regulators [Transcription]; Region: MarR; COG1846 373994004950 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994004951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994004952 S-adenosylmethionine binding site [chemical binding]; other site 373994004953 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 373994004954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994004955 dimer interface [polypeptide binding]; other site 373994004956 phosphorylation site [posttranslational modification] 373994004957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994004958 ATP binding site [chemical binding]; other site 373994004959 Mg2+ binding site [ion binding]; other site 373994004960 G-X-G motif; other site 373994004961 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994004962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994004963 active site 373994004964 phosphorylation site [posttranslational modification] 373994004965 intermolecular recognition site; other site 373994004966 dimerization interface [polypeptide binding]; other site 373994004967 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994004968 DNA binding site [nucleotide binding] 373994004969 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 373994004970 Methylamine utilisation protein MauE; Region: MauE; pfam07291 373994004971 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 373994004972 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 373994004973 DNA binding residues [nucleotide binding] 373994004974 dimer interface [polypeptide binding]; other site 373994004975 metal binding site [ion binding]; metal-binding site 373994004976 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 373994004977 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 373994004978 YtkA-like; Region: YtkA; pfam13115 373994004979 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994004980 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994004981 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994004982 YtkA-like; Region: YtkA; pfam13115 373994004983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994004984 binding surface 373994004985 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373994004986 TPR motif; other site 373994004987 TPR repeat; Region: TPR_11; pfam13414 373994004988 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 373994004989 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 373994004990 Multicopper oxidase; Region: Cu-oxidase; pfam00394 373994004991 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 373994004992 Predicted metal-binding protein [General function prediction only]; Region: COG3019 373994004993 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994004994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994004995 S-adenosylmethionine binding site [chemical binding]; other site 373994004996 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 373994004997 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373994004998 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 373994004999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373994005000 putative DNA binding site [nucleotide binding]; other site 373994005001 dimerization interface [polypeptide binding]; other site 373994005002 putative Zn2+ binding site [ion binding]; other site 373994005003 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 373994005004 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373994005005 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373994005006 dimerization interface [polypeptide binding]; other site 373994005007 putative DNA binding site [nucleotide binding]; other site 373994005008 putative Zn2+ binding site [ion binding]; other site 373994005009 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 373994005010 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 373994005011 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373994005012 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373994005013 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373994005014 DNA binding residues [nucleotide binding] 373994005015 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 373994005016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994005017 dimer interface [polypeptide binding]; other site 373994005018 phosphorylation site [posttranslational modification] 373994005019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994005020 ATP binding site [chemical binding]; other site 373994005021 Mg2+ binding site [ion binding]; other site 373994005022 G-X-G motif; other site 373994005023 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994005024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994005025 active site 373994005026 phosphorylation site [posttranslational modification] 373994005027 intermolecular recognition site; other site 373994005028 dimerization interface [polypeptide binding]; other site 373994005029 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994005030 DNA binding site [nucleotide binding] 373994005031 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 373994005032 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 373994005033 CopC domain; Region: CopC; cl01012 373994005034 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 373994005035 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994005036 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 373994005037 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994005038 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 373994005039 Low molecular weight phosphatase family; Region: LMWPc; cd00115 373994005040 active site 373994005041 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 373994005042 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 373994005043 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 373994005044 arsenical-resistance protein; Region: acr3; TIGR00832 373994005045 PBP superfamily domain; Region: PBP_like_2; cl17296 373994005046 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373994005047 dimerization interface [polypeptide binding]; other site 373994005048 putative DNA binding site [nucleotide binding]; other site 373994005049 putative Zn2+ binding site [ion binding]; other site 373994005050 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 373994005051 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 373994005052 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373994005053 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373994005054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373994005055 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 373994005056 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 373994005057 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 373994005058 Multicopper oxidase; Region: Cu-oxidase; pfam00394 373994005059 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 373994005060 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 373994005061 Putative phosphatase (DUF442); Region: DUF442; cl17385 373994005062 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 373994005063 dimerization interface [polypeptide binding]; other site 373994005064 Domain of unknown function (DUF305); Region: DUF305; cl17794 373994005065 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 373994005066 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373994005067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994005068 motif II; other site 373994005069 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994005070 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 373994005071 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 373994005072 metal-binding site [ion binding] 373994005073 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 373994005074 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 373994005075 metal-binding site [ion binding] 373994005076 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373994005077 Soluble P-type ATPase [General function prediction only]; Region: COG4087 373994005078 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 373994005079 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 373994005080 DNA methylase; Region: N6_N4_Mtase; cl17433 373994005081 DNA methylase; Region: N6_N4_Mtase; pfam01555 373994005082 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 373994005083 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 373994005084 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 373994005085 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 373994005086 cofactor binding site; other site 373994005087 DNA binding site [nucleotide binding] 373994005088 substrate interaction site [chemical binding]; other site 373994005089 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 373994005090 NlpC/P60 family; Region: NLPC_P60; cl17555 373994005091 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 373994005092 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 373994005093 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 373994005094 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 373994005095 active site 373994005096 catalytic residues [active] 373994005097 DNA binding site [nucleotide binding] 373994005098 Int/Topo IB signature motif; other site 373994005099 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 373994005100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 373994005101 Histidine kinase; Region: HisKA_3; pfam07730 373994005102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994005103 ATP binding site [chemical binding]; other site 373994005104 Mg2+ binding site [ion binding]; other site 373994005105 G-X-G motif; other site 373994005106 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 373994005107 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373994005108 active site 373994005109 metal binding site [ion binding]; metal-binding site 373994005110 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 373994005111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994005112 non-specific DNA binding site [nucleotide binding]; other site 373994005113 salt bridge; other site 373994005114 sequence-specific DNA binding site [nucleotide binding]; other site 373994005115 KGK domain; Region: KGK; pfam08872 373994005116 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 373994005117 active site 373994005118 metal binding site [ion binding]; metal-binding site 373994005119 interdomain interaction site; other site 373994005120 Virulence-associated protein E; Region: VirE; pfam05272 373994005121 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 373994005122 active site 373994005123 catalytic residues [active] 373994005124 DNA binding site [nucleotide binding] 373994005125 Int/Topo IB signature motif; other site 373994005126 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994005127 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994005128 active site 373994005129 ATP binding site [chemical binding]; other site 373994005130 substrate binding site [chemical binding]; other site 373994005131 activation loop (A-loop); other site 373994005132 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994005133 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994005134 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994005135 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994005136 GUN4-like; Region: GUN4; pfam05419 373994005137 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 373994005138 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 373994005139 iron-sulfur cluster [ion binding]; other site 373994005140 [2Fe-2S] cluster binding site [ion binding]; other site 373994005141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994005142 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994005143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994005144 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 373994005145 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 373994005146 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994005147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994005148 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 373994005149 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 373994005150 NADP binding site [chemical binding]; other site 373994005151 homodimer interface [polypeptide binding]; other site 373994005152 substrate binding site [chemical binding]; other site 373994005153 active site 373994005154 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 373994005155 classical (c) SDRs; Region: SDR_c; cd05233 373994005156 NAD(P) binding site [chemical binding]; other site 373994005157 active site 373994005158 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 373994005159 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 373994005160 trimer interface [polypeptide binding]; other site 373994005161 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 373994005162 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 373994005163 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 373994005164 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 373994005165 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 373994005166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994005167 catalytic residue [active] 373994005168 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 373994005169 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 373994005170 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 373994005171 substrate binding site [chemical binding]; other site 373994005172 active site 373994005173 catalytic residues [active] 373994005174 heterodimer interface [polypeptide binding]; other site 373994005175 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 373994005176 active site 373994005177 ribulose/triose binding site [chemical binding]; other site 373994005178 phosphate binding site [ion binding]; other site 373994005179 substrate (anthranilate) binding pocket [chemical binding]; other site 373994005180 product (indole) binding pocket [chemical binding]; other site 373994005181 anthranilate synthase; Provisional; Region: PRK13566 373994005182 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 373994005183 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 373994005184 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 373994005185 glutamine binding [chemical binding]; other site 373994005186 catalytic triad [active] 373994005187 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 373994005188 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 373994005189 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 373994005190 active site 373994005191 metal binding site [ion binding]; metal-binding site 373994005192 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 373994005193 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 373994005194 catalytic residues [active] 373994005195 arogenate dehydrogenase; Region: PLN02256 373994005196 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 373994005197 putative glycosyl transferase; Provisional; Region: PRK10307 373994005198 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 373994005199 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 373994005200 UbiA prenyltransferase family; Region: UbiA; pfam01040 373994005201 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 373994005202 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 373994005203 active site 373994005204 Uncharacterized conserved protein [Function unknown]; Region: COG3391 373994005205 NHL repeat; Region: NHL; pfam01436 373994005206 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 373994005207 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 373994005208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 373994005209 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 373994005210 NAD binding site [chemical binding]; other site 373994005211 Phe binding site; other site 373994005212 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 373994005213 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 373994005214 PYR/PP interface [polypeptide binding]; other site 373994005215 dimer interface [polypeptide binding]; other site 373994005216 TPP binding site [chemical binding]; other site 373994005217 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 373994005218 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 373994005219 TPP-binding site [chemical binding]; other site 373994005220 PAS domain; Region: PAS; smart00091 373994005221 PAS domain; Region: PAS_9; pfam13426 373994005222 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994005223 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 373994005224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994005225 putative active site [active] 373994005226 heme pocket [chemical binding]; other site 373994005227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994005228 dimer interface [polypeptide binding]; other site 373994005229 phosphorylation site [posttranslational modification] 373994005230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994005231 ATP binding site [chemical binding]; other site 373994005232 Mg2+ binding site [ion binding]; other site 373994005233 G-X-G motif; other site 373994005234 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994005235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994005236 active site 373994005237 phosphorylation site [posttranslational modification] 373994005238 intermolecular recognition site; other site 373994005239 dimerization interface [polypeptide binding]; other site 373994005240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994005241 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994005242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994005243 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 373994005244 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 373994005245 trimer interface [polypeptide binding]; other site 373994005246 active site 373994005247 substrate binding site [chemical binding]; other site 373994005248 CoA binding site [chemical binding]; other site 373994005249 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 373994005250 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 373994005251 trimer interface [polypeptide binding]; other site 373994005252 active site 373994005253 substrate binding site [chemical binding]; other site 373994005254 CoA binding site [chemical binding]; other site 373994005255 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 373994005256 OstA-like protein; Region: OstA; cl00844 373994005257 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 373994005258 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 373994005259 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 373994005260 active site 373994005261 catalytic site [active] 373994005262 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 373994005263 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 373994005264 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 373994005265 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 373994005266 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 373994005267 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 373994005268 putative active site [active] 373994005269 catalytic residue [active] 373994005270 Leucine-rich repeats, typical (most populated) subfamily; Region: LRR_TYP; cl15310 373994005271 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994005272 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 373994005273 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994005274 Leucine-rich repeats; other site 373994005275 Substrate binding site [chemical binding]; other site 373994005276 Leucine rich repeat; Region: LRR_8; pfam13855 373994005277 Leucine rich repeat; Region: LRR_8; pfam13855 373994005278 Leucine rich repeat; Region: LRR_8; pfam13855 373994005279 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 373994005280 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373994005281 G1 box; other site 373994005282 GTP/Mg2+ binding site [chemical binding]; other site 373994005283 G2 box; other site 373994005284 Switch I region; other site 373994005285 G3 box; other site 373994005286 Switch II region; other site 373994005287 G4 box; other site 373994005288 G5 box; other site 373994005289 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 373994005290 Predicted methyltransferases [General function prediction only]; Region: COG0313 373994005291 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 373994005292 putative SAM binding site [chemical binding]; other site 373994005293 putative homodimer interface [polypeptide binding]; other site 373994005294 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 373994005295 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373994005296 substrate binding site [chemical binding]; other site 373994005297 ATP binding site [chemical binding]; other site 373994005298 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 373994005299 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 373994005300 active site 373994005301 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 373994005302 hypothetical protein; Provisional; Region: PRK05463 373994005303 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 373994005304 metal binding site 2 [ion binding]; metal-binding site 373994005305 putative DNA binding helix; other site 373994005306 metal binding site 1 [ion binding]; metal-binding site 373994005307 dimer interface [polypeptide binding]; other site 373994005308 structural Zn2+ binding site [ion binding]; other site 373994005309 Subtilase family; Region: Peptidase_S8; pfam00082 373994005310 active site 373994005311 catalytic residues [active] 373994005312 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 373994005313 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 373994005314 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 373994005315 putative active site [active] 373994005316 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 373994005317 substrate binding site; other site 373994005318 dimer interface; other site 373994005319 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 373994005320 Transcriptional regulators [Transcription]; Region: MarR; COG1846 373994005321 Protein of unknown function (DUF760); Region: DUF760; pfam05542 373994005322 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 373994005323 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994005324 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373994005325 protein binding site [polypeptide binding]; other site 373994005326 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 373994005327 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 373994005328 Peptidase family M23; Region: Peptidase_M23; pfam01551 373994005329 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 373994005330 catalytic triad [active] 373994005331 conserved cis-peptide bond; other site 373994005332 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994005333 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994005334 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994005335 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994005336 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994005337 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994005338 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 373994005339 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 373994005340 active site 373994005341 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 373994005342 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 373994005343 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 373994005344 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 373994005345 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 373994005346 C-terminal peptidase (prc); Region: prc; TIGR00225 373994005347 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 373994005348 protein binding site [polypeptide binding]; other site 373994005349 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 373994005350 Catalytic dyad [active] 373994005351 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 373994005352 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 373994005353 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 373994005354 elongation factor G; Reviewed; Region: PRK12740 373994005355 G1 box; other site 373994005356 putative GEF interaction site [polypeptide binding]; other site 373994005357 GTP/Mg2+ binding site [chemical binding]; other site 373994005358 Switch I region; other site 373994005359 G2 box; other site 373994005360 G3 box; other site 373994005361 Switch II region; other site 373994005362 G4 box; other site 373994005363 G5 box; other site 373994005364 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 373994005365 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 373994005366 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 373994005367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994005368 TPR motif; other site 373994005369 TPR repeat; Region: TPR_11; pfam13414 373994005370 binding surface 373994005371 TPR repeat; Region: TPR_11; pfam13414 373994005372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994005373 binding surface 373994005374 TPR motif; other site 373994005375 TPR repeat; Region: TPR_11; pfam13414 373994005376 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373994005377 Predicted membrane protein [Function unknown]; Region: COG3431 373994005378 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 373994005379 Domain of unknown function DUF21; Region: DUF21; pfam01595 373994005380 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 373994005381 Transporter associated domain; Region: CorC_HlyC; smart01091 373994005382 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 373994005383 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 373994005384 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994005385 ATP binding site [chemical binding]; other site 373994005386 putative Mg++ binding site [ion binding]; other site 373994005387 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994005388 nucleotide binding region [chemical binding]; other site 373994005389 ATP-binding site [chemical binding]; other site 373994005390 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 373994005391 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994005392 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994005393 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994005394 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994005395 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994005396 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994005397 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994005398 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 373994005399 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 373994005400 catalytic triad [active] 373994005401 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 373994005402 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994005403 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994005404 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994005405 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994005406 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 373994005407 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 373994005408 active site 373994005409 catalytic residues [active] 373994005410 von Willebrand factor type A domain; Region: VWA_2; pfam13519 373994005411 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373994005412 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 373994005413 substrate binding pocket [chemical binding]; other site 373994005414 membrane-bound complex binding site; other site 373994005415 hinge residues; other site 373994005416 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 373994005417 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 373994005418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994005419 dimer interface [polypeptide binding]; other site 373994005420 conserved gate region; other site 373994005421 putative PBP binding loops; other site 373994005422 ABC-ATPase subunit interface; other site 373994005423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994005424 dimer interface [polypeptide binding]; other site 373994005425 conserved gate region; other site 373994005426 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 373994005427 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 373994005428 Walker A/P-loop; other site 373994005429 ATP binding site [chemical binding]; other site 373994005430 Q-loop/lid; other site 373994005431 ABC transporter signature motif; other site 373994005432 Walker B; other site 373994005433 D-loop; other site 373994005434 H-loop/switch region; other site 373994005435 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 373994005436 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 373994005437 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 373994005438 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 373994005439 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 373994005440 Malic enzyme, N-terminal domain; Region: malic; pfam00390 373994005441 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 373994005442 putative NAD(P) binding site [chemical binding]; other site 373994005443 hypothetical protein; Provisional; Region: PRK09866 373994005444 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373994005445 G1 box; other site 373994005446 GTP/Mg2+ binding site [chemical binding]; other site 373994005447 G2 box; other site 373994005448 Switch I region; other site 373994005449 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373994005450 G3 box; other site 373994005451 Switch II region; other site 373994005452 GTP/Mg2+ binding site [chemical binding]; other site 373994005453 G4 box; other site 373994005454 G5 box; other site 373994005455 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 373994005456 protein I interface; other site 373994005457 D2 interface; other site 373994005458 protein T interface; other site 373994005459 chlorophyll binding site; other site 373994005460 beta carotene binding site; other site 373994005461 pheophytin binding site; other site 373994005462 manganese-stabilizing polypeptide interface; other site 373994005463 CP43 interface; other site 373994005464 protein L interface; other site 373994005465 oxygen evolving complex binding site; other site 373994005466 bromide binding site; other site 373994005467 quinone binding site; other site 373994005468 Fe binding site [ion binding]; other site 373994005469 core light harvesting interface; other site 373994005470 cytochrome b559 alpha subunit interface; other site 373994005471 cytochrome c-550 interface; other site 373994005472 protein J interface; other site 373994005473 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 373994005474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994005475 Coenzyme A binding pocket [chemical binding]; other site 373994005476 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 373994005477 protein I interface; other site 373994005478 D2 interface; other site 373994005479 protein T interface; other site 373994005480 chlorophyll binding site; other site 373994005481 beta carotene binding site; other site 373994005482 pheophytin binding site; other site 373994005483 manganese-stabilizing polypeptide interface; other site 373994005484 CP43 interface; other site 373994005485 protein L interface; other site 373994005486 oxygen evolving complex binding site; other site 373994005487 bromide binding site; other site 373994005488 quinone binding site; other site 373994005489 Fe binding site [ion binding]; other site 373994005490 core light harvesting interface; other site 373994005491 cytochrome b559 alpha subunit interface; other site 373994005492 cytochrome c-550 interface; other site 373994005493 protein J interface; other site 373994005494 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 373994005495 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 373994005496 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 373994005497 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994005498 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994005499 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994005500 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 373994005501 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 373994005502 ribonuclease E; Reviewed; Region: rne; PRK10811 373994005503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994005504 AAA domain; Region: AAA_21; pfam13304 373994005505 Walker A/P-loop; other site 373994005506 ATP binding site [chemical binding]; other site 373994005507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994005508 ABC transporter signature motif; other site 373994005509 Walker B; other site 373994005510 D-loop; other site 373994005511 H-loop/switch region; other site 373994005512 TIGR02646 family protein; Region: TIGR02646 373994005513 Response regulator receiver domain; Region: Response_reg; pfam00072 373994005514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994005515 active site 373994005516 phosphorylation site [posttranslational modification] 373994005517 intermolecular recognition site; other site 373994005518 dimerization interface [polypeptide binding]; other site 373994005519 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994005520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 373994005521 dimer interface [polypeptide binding]; other site 373994005522 phosphorylation site [posttranslational modification] 373994005523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994005524 ATP binding site [chemical binding]; other site 373994005525 Mg2+ binding site [ion binding]; other site 373994005526 G-X-G motif; other site 373994005527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994005528 Response regulator receiver domain; Region: Response_reg; pfam00072 373994005529 active site 373994005530 phosphorylation site [posttranslational modification] 373994005531 intermolecular recognition site; other site 373994005532 dimerization interface [polypeptide binding]; other site 373994005533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994005534 HAMP domain; Region: HAMP; pfam00672 373994005535 dimerization interface [polypeptide binding]; other site 373994005536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994005537 dimer interface [polypeptide binding]; other site 373994005538 phosphorylation site [posttranslational modification] 373994005539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994005540 ATP binding site [chemical binding]; other site 373994005541 Mg2+ binding site [ion binding]; other site 373994005542 G-X-G motif; other site 373994005543 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 373994005544 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 373994005545 putative active site [active] 373994005546 Zn binding site [ion binding]; other site 373994005547 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373994005548 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994005549 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994005550 active site 373994005551 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 373994005552 Calx-beta domain; Region: Calx-beta; cl02522 373994005553 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 373994005554 hydrolase, alpha/beta fold family protein; Region: PLN02824 373994005555 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994005556 Predicted metalloprotease [General function prediction only]; Region: COG2321 373994005557 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 373994005558 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 373994005559 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 373994005560 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 373994005561 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 373994005562 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 373994005563 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 373994005564 DDE superfamily endonuclease; Region: DDE_4; pfam13359 373994005565 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 373994005566 putative active site [active] 373994005567 Uncharacterized conserved protein [Function unknown]; Region: COG0398 373994005568 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 373994005569 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 373994005570 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 373994005571 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 373994005572 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 373994005573 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 373994005574 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 373994005575 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994005576 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994005577 active site 373994005578 metal binding site [ion binding]; metal-binding site 373994005579 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373994005580 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 373994005581 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 373994005582 Walker A/P-loop; other site 373994005583 ATP binding site [chemical binding]; other site 373994005584 Q-loop/lid; other site 373994005585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994005586 ABC transporter signature motif; other site 373994005587 Walker B; other site 373994005588 D-loop; other site 373994005589 H-loop/switch region; other site 373994005590 transaldolase-like protein; Provisional; Region: PTZ00411 373994005591 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 373994005592 active site 373994005593 dimer interface [polypeptide binding]; other site 373994005594 catalytic residue [active] 373994005595 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 373994005596 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 373994005597 domain interfaces; other site 373994005598 active site 373994005599 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 373994005600 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 373994005601 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 373994005602 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 373994005603 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 373994005604 putative ligand binding site [chemical binding]; other site 373994005605 putative NAD binding site [chemical binding]; other site 373994005606 catalytic site [active] 373994005607 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 373994005608 homodimer interface [polypeptide binding]; other site 373994005609 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 373994005610 active site pocket [active] 373994005611 putative phosphoketolase; Provisional; Region: PRK05261 373994005612 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 373994005613 TPP-binding site; other site 373994005614 XFP C-terminal domain; Region: XFP_C; pfam09363 373994005615 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 373994005616 RimM N-terminal domain; Region: RimM; pfam01782 373994005617 PRC-barrel domain; Region: PRC; pfam05239 373994005618 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 373994005619 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373994005620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994005621 homodimer interface [polypeptide binding]; other site 373994005622 catalytic residue [active] 373994005623 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 373994005624 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 373994005625 substrate binding site [chemical binding]; other site 373994005626 catalytic Zn binding site [ion binding]; other site 373994005627 NAD binding site [chemical binding]; other site 373994005628 structural Zn binding site [ion binding]; other site 373994005629 dimer interface [polypeptide binding]; other site 373994005630 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 373994005631 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 373994005632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994005633 Coenzyme A binding pocket [chemical binding]; other site 373994005634 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 373994005635 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 373994005636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994005637 dimer interface [polypeptide binding]; other site 373994005638 conserved gate region; other site 373994005639 putative PBP binding loops; other site 373994005640 ABC-ATPase subunit interface; other site 373994005641 Electron transfer DM13; Region: DM13; pfam10517 373994005642 Electron transfer DM13; Region: DM13; pfam10517 373994005643 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 373994005644 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 373994005645 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 373994005646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994005647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994005648 active site 373994005649 phosphorylation site [posttranslational modification] 373994005650 intermolecular recognition site; other site 373994005651 dimerization interface [polypeptide binding]; other site 373994005652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994005653 DNA binding site [nucleotide binding] 373994005654 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 373994005655 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 373994005656 G2 box; other site 373994005657 Switch I region; other site 373994005658 G3 box; other site 373994005659 Switch II region; other site 373994005660 GTP/Mg2+ binding site [chemical binding]; other site 373994005661 G4 box; other site 373994005662 G5 box; other site 373994005663 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 373994005664 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 373994005665 heme-binding site [chemical binding]; other site 373994005666 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373994005667 Chain length determinant protein; Region: Wzz; pfam02706 373994005668 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 373994005669 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 373994005670 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994005671 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 373994005672 O-Antigen ligase; Region: Wzy_C; pfam04932 373994005673 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 373994005674 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 373994005675 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994005676 active site 373994005677 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994005678 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 373994005679 active site 373994005680 Core-2/I-Branching enzyme; Region: Branch; pfam02485 373994005681 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 373994005682 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 373994005683 Core-2/I-Branching enzyme; Region: Branch; pfam02485 373994005684 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994005685 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994005686 active site 373994005687 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 373994005688 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 373994005689 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994005690 active site 373994005691 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994005692 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 373994005693 putative ADP-binding pocket [chemical binding]; other site 373994005694 O-Antigen ligase; Region: Wzy_C; pfam04932 373994005695 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 373994005696 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 373994005697 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994005698 active site 373994005699 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994005700 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994005701 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373994005702 Chain length determinant protein; Region: Wzz; cl15801 373994005703 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 373994005704 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 373994005705 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994005706 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 373994005707 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994005708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994005709 active site 373994005710 phosphorylation site [posttranslational modification] 373994005711 intermolecular recognition site; other site 373994005712 dimerization interface [polypeptide binding]; other site 373994005713 Response regulator receiver domain; Region: Response_reg; pfam00072 373994005714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994005715 active site 373994005716 phosphorylation site [posttranslational modification] 373994005717 intermolecular recognition site; other site 373994005718 dimerization interface [polypeptide binding]; other site 373994005719 PAS domain S-box; Region: sensory_box; TIGR00229 373994005720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994005721 putative active site [active] 373994005722 heme pocket [chemical binding]; other site 373994005723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994005724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994005725 dimer interface [polypeptide binding]; other site 373994005726 phosphorylation site [posttranslational modification] 373994005727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994005728 ATP binding site [chemical binding]; other site 373994005729 Mg2+ binding site [ion binding]; other site 373994005730 G-X-G motif; other site 373994005731 PAS domain; Region: PAS_9; pfam13426 373994005732 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994005733 GAF domain; Region: GAF; pfam01590 373994005734 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994005735 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994005736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994005737 dimer interface [polypeptide binding]; other site 373994005738 phosphorylation site [posttranslational modification] 373994005739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994005740 ATP binding site [chemical binding]; other site 373994005741 Mg2+ binding site [ion binding]; other site 373994005742 G-X-G motif; other site 373994005743 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994005744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994005745 active site 373994005746 phosphorylation site [posttranslational modification] 373994005747 intermolecular recognition site; other site 373994005748 dimerization interface [polypeptide binding]; other site 373994005749 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994005750 DNA binding site [nucleotide binding] 373994005751 Hpt domain; Region: Hpt; pfam01627 373994005752 putative binding surface; other site 373994005753 active site 373994005754 Response regulator receiver domain; Region: Response_reg; pfam00072 373994005755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994005756 active site 373994005757 phosphorylation site [posttranslational modification] 373994005758 intermolecular recognition site; other site 373994005759 dimerization interface [polypeptide binding]; other site 373994005760 Response regulator receiver domain; Region: Response_reg; pfam00072 373994005761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994005762 active site 373994005763 phosphorylation site [posttranslational modification] 373994005764 intermolecular recognition site; other site 373994005765 dimerization interface [polypeptide binding]; other site 373994005766 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373994005767 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373994005768 metal binding site [ion binding]; metal-binding site 373994005769 active site 373994005770 I-site; other site 373994005771 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994005772 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994005773 structural tetrad; other site 373994005774 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994005775 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994005776 structural tetrad; other site 373994005777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994005778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994005779 dimer interface [polypeptide binding]; other site 373994005780 phosphorylation site [posttranslational modification] 373994005781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994005782 ATP binding site [chemical binding]; other site 373994005783 Mg2+ binding site [ion binding]; other site 373994005784 G-X-G motif; other site 373994005785 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994005786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994005787 active site 373994005788 phosphorylation site [posttranslational modification] 373994005789 intermolecular recognition site; other site 373994005790 dimerization interface [polypeptide binding]; other site 373994005791 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373994005792 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 373994005793 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 373994005794 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 373994005795 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 373994005796 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 373994005797 trimer interface [polypeptide binding]; other site 373994005798 active site 373994005799 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 373994005800 catalytic site [active] 373994005801 short chain dehydrogenase; Validated; Region: PRK06182 373994005802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994005803 NAD(P) binding site [chemical binding]; other site 373994005804 active site 373994005805 Amidinotransferase; Region: Amidinotransf; cl12043 373994005806 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 373994005807 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 373994005808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373994005809 catalytic residue [active] 373994005810 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 373994005811 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373994005812 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 373994005813 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 373994005814 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 373994005815 active site 373994005816 catalytic site [active] 373994005817 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 373994005818 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 373994005819 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 373994005820 catalytic site [active] 373994005821 active site 373994005822 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 373994005823 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 373994005824 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 373994005825 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 373994005826 active site 373994005827 catalytic site [active] 373994005828 trehalose synthase; Region: treS_nterm; TIGR02456 373994005829 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 373994005830 active site 373994005831 catalytic site [active] 373994005832 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 373994005833 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 373994005834 4-alpha-glucanotransferase; Provisional; Region: PRK14508 373994005835 PRC-barrel domain; Region: PRC; pfam05239 373994005836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 373994005837 PRC-barrel domain; Region: PRC; pfam05239 373994005838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 373994005839 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 373994005840 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 373994005841 classical (c) SDRs; Region: SDR_c; cd05233 373994005842 NAD(P) binding site [chemical binding]; other site 373994005843 active site 373994005844 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994005845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994005846 S-adenosylmethionine binding site [chemical binding]; other site 373994005847 Creatinine amidohydrolase; Region: Creatininase; pfam02633 373994005848 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 373994005849 FAD binding domain; Region: FAD_binding_4; pfam01565 373994005850 Radical SAM superfamily; Region: Radical_SAM; pfam04055 373994005851 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994005852 FeS/SAM binding site; other site 373994005853 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 373994005854 active site 373994005855 catalytic site [active] 373994005856 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 373994005857 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994005858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994005859 ATP binding site [chemical binding]; other site 373994005860 Mg2+ binding site [ion binding]; other site 373994005861 G-X-G motif; other site 373994005862 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373994005863 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 373994005864 active site 373994005865 metal binding site [ion binding]; metal-binding site 373994005866 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994005867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994005868 S-adenosylmethionine binding site [chemical binding]; other site 373994005869 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994005870 active site 373994005871 metal binding site [ion binding]; metal-binding site 373994005872 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 373994005873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994005874 Walker A/P-loop; other site 373994005875 ATP binding site [chemical binding]; other site 373994005876 Q-loop/lid; other site 373994005877 ABC transporter signature motif; other site 373994005878 Walker B; other site 373994005879 D-loop; other site 373994005880 H-loop/switch region; other site 373994005881 Transposase; Region: DEDD_Tnp_IS110; pfam01548 373994005882 Domain of unknown function (DUF202); Region: DUF202; cl09954 373994005883 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994005884 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994005885 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 373994005886 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 373994005887 G8 domain; Region: G8; pfam10162 373994005888 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 373994005889 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 373994005890 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994005891 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 373994005892 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 373994005893 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373994005894 catalytic residue [active] 373994005895 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 373994005896 Leucine-rich repeats; other site 373994005897 Substrate binding site [chemical binding]; other site 373994005898 Leucine rich repeat; Region: LRR_8; pfam13855 373994005899 Leucine rich repeat; Region: LRR_8; pfam13855 373994005900 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 373994005901 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 373994005902 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994005903 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994005904 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994005905 Transcriptional regulator [Transcription]; Region: LytR; COG1316 373994005906 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 373994005907 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 373994005908 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 373994005909 Substrate binding site; other site 373994005910 Cupin domain; Region: Cupin_2; cl17218 373994005911 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 373994005912 ABC1 family; Region: ABC1; cl17513 373994005913 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 373994005914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994005915 Walker A/P-loop; other site 373994005916 ATP binding site [chemical binding]; other site 373994005917 Q-loop/lid; other site 373994005918 ABC transporter signature motif; other site 373994005919 Walker B; other site 373994005920 D-loop; other site 373994005921 H-loop/switch region; other site 373994005922 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 373994005923 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 373994005924 active site 373994005925 DNA binding site [nucleotide binding] 373994005926 Int/Topo IB signature motif; other site 373994005927 catalytic residues [active] 373994005928 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 373994005929 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 373994005930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994005931 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 373994005932 active site 373994005933 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 373994005934 Response regulator receiver domain; Region: Response_reg; pfam00072 373994005935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994005936 active site 373994005937 phosphorylation site [posttranslational modification] 373994005938 intermolecular recognition site; other site 373994005939 dimerization interface [polypeptide binding]; other site 373994005940 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 373994005941 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 373994005942 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994005943 Cytochrome P450; Region: p450; pfam00067 373994005944 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994005945 Uncharacterized conserved protein [Function unknown]; Region: COG3349 373994005946 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 373994005947 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 373994005948 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 373994005949 putative active site [active] 373994005950 putative catalytic site [active] 373994005951 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 373994005952 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 373994005953 TM-ABC transporter signature motif; other site 373994005954 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 373994005955 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 373994005956 TM-ABC transporter signature motif; other site 373994005957 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 373994005958 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 373994005959 Walker A/P-loop; other site 373994005960 ATP binding site [chemical binding]; other site 373994005961 Q-loop/lid; other site 373994005962 ABC transporter signature motif; other site 373994005963 Walker B; other site 373994005964 D-loop; other site 373994005965 H-loop/switch region; other site 373994005966 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 373994005967 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 373994005968 hypothetical protein; Validated; Region: PRK00029 373994005969 Uncharacterized conserved protein [Function unknown]; Region: COG0397 373994005970 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 373994005971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 373994005972 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994005973 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994005974 biotin synthase; Region: bioB; TIGR00433 373994005975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994005976 FeS/SAM binding site; other site 373994005977 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 373994005978 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 373994005979 active site 373994005980 dimer interface [polypeptide binding]; other site 373994005981 metal binding site [ion binding]; metal-binding site 373994005982 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994005983 putative active site [active] 373994005984 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 373994005985 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 373994005986 NAD(P) binding site [chemical binding]; other site 373994005987 homodimer interface [polypeptide binding]; other site 373994005988 substrate binding site [chemical binding]; other site 373994005989 active site 373994005990 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 373994005991 putative active site [active] 373994005992 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 373994005993 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 373994005994 inhibitor-cofactor binding pocket; inhibition site 373994005995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994005996 catalytic residue [active] 373994005997 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 373994005998 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 373994005999 putative trimer interface [polypeptide binding]; other site 373994006000 putative CoA binding site [chemical binding]; other site 373994006001 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 373994006002 putative ADP-binding pocket [chemical binding]; other site 373994006003 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994006004 Bacterial sugar transferase; Region: Bac_transf; pfam02397 373994006005 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373994006006 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 373994006007 putative NAD(P) binding site [chemical binding]; other site 373994006008 active site 373994006009 putative substrate binding site [chemical binding]; other site 373994006010 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994006011 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994006012 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994006013 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 373994006014 putative ADP-binding pocket [chemical binding]; other site 373994006015 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 373994006016 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 373994006017 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994006018 putative active site [active] 373994006019 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 373994006020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994006021 non-specific DNA binding site [nucleotide binding]; other site 373994006022 salt bridge; other site 373994006023 sequence-specific DNA binding site [nucleotide binding]; other site 373994006024 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 373994006025 putative active site [active] 373994006026 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 373994006027 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373994006028 Chain length determinant protein; Region: Wzz; pfam02706 373994006029 Chain length determinant protein; Region: Wzz; cl15801 373994006030 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 373994006031 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994006032 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994006033 putative active site [active] 373994006034 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 373994006035 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 373994006036 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 373994006037 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 373994006038 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994006039 catalytic loop [active] 373994006040 iron binding site [ion binding]; other site 373994006041 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 373994006042 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 373994006043 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 373994006044 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 373994006045 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 373994006046 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 373994006047 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 373994006048 Predicted membrane protein [Function unknown]; Region: COG4270 373994006049 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 373994006050 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 373994006051 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 373994006052 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 373994006053 putative NAD(P) binding site [chemical binding]; other site 373994006054 active site 373994006055 putative substrate binding site [chemical binding]; other site 373994006056 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 373994006057 FMN binding site [chemical binding]; other site 373994006058 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 373994006059 substrate binding site [chemical binding]; other site 373994006060 putative catalytic residue [active] 373994006061 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 373994006062 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 373994006063 active site 373994006064 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 373994006065 active site 373994006066 Acyl transferase domain; Region: Acyl_transf_1; cl08282 373994006067 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 373994006068 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 373994006069 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 373994006070 putative NADP binding site [chemical binding]; other site 373994006071 active site 373994006072 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 373994006073 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 373994006074 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 373994006075 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 373994006076 active site 373994006077 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 373994006078 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 373994006079 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 373994006080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994006081 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 373994006082 ParB-like nuclease domain; Region: ParB; smart00470 373994006083 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 373994006084 Protein of Unknown function (DUF1690); Region: DUF1690; pfam07956 373994006085 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994006086 DevC protein; Region: devC; TIGR01185 373994006087 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994006088 FtsX-like permease family; Region: FtsX; pfam02687 373994006089 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373994006090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994006091 NAD(P) binding site [chemical binding]; other site 373994006092 active site 373994006093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 373994006094 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 373994006095 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994006096 active site 373994006097 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994006098 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 373994006099 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 373994006100 homodimer interface [polypeptide binding]; other site 373994006101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994006102 catalytic residue [active] 373994006103 Protein of unknown function (DUF760); Region: DUF760; pfam05542 373994006104 Protein of unknown function DUF89; Region: DUF89; pfam01937 373994006105 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 373994006106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994006107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994006108 active site 373994006109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994006110 phosphorylation site [posttranslational modification] 373994006111 intermolecular recognition site; other site 373994006112 dimerization interface [polypeptide binding]; other site 373994006113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994006114 dimer interface [polypeptide binding]; other site 373994006115 phosphorylation site [posttranslational modification] 373994006116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994006117 ATP binding site [chemical binding]; other site 373994006118 Mg2+ binding site [ion binding]; other site 373994006119 G-X-G motif; other site 373994006120 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 373994006121 FOG: CBS domain [General function prediction only]; Region: COG0517 373994006122 PAS fold; Region: PAS_4; pfam08448 373994006123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994006124 putative active site [active] 373994006125 heme pocket [chemical binding]; other site 373994006126 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994006127 GAF domain; Region: GAF; pfam01590 373994006128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994006129 PAS fold; Region: PAS_3; pfam08447 373994006130 putative active site [active] 373994006131 heme pocket [chemical binding]; other site 373994006132 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 373994006133 Histidine kinase; Region: HisKA_2; pfam07568 373994006134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994006135 ATP binding site [chemical binding]; other site 373994006136 Mg2+ binding site [ion binding]; other site 373994006137 G-X-G motif; other site 373994006138 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 373994006139 FAD binding domain; Region: FAD_binding_4; pfam01565 373994006140 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373994006141 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 373994006142 Cysteine-rich domain; Region: CCG; pfam02754 373994006143 Cysteine-rich domain; Region: CCG; pfam02754 373994006144 Uncharacterized conserved protein [Function unknown]; Region: COG1801 373994006145 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 373994006146 nucleophilic elbow; other site 373994006147 catalytic triad; other site 373994006148 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994006149 putative active site [active] 373994006150 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 373994006151 PLD-like domain; Region: PLDc_2; pfam13091 373994006152 putative active site [active] 373994006153 catalytic site [active] 373994006154 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 373994006155 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994006156 ATP-binding site [chemical binding]; other site 373994006157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994006158 non-specific DNA binding site [nucleotide binding]; other site 373994006159 salt bridge; other site 373994006160 sequence-specific DNA binding site [nucleotide binding]; other site 373994006161 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994006162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994006163 ATP binding site [chemical binding]; other site 373994006164 putative Mg++ binding site [ion binding]; other site 373994006165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994006166 nucleotide binding region [chemical binding]; other site 373994006167 ATP-binding site [chemical binding]; other site 373994006168 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 373994006169 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 373994006170 glutaminase active site [active] 373994006171 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 373994006172 dimer interface [polypeptide binding]; other site 373994006173 active site 373994006174 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 373994006175 dimer interface [polypeptide binding]; other site 373994006176 active site 373994006177 photosystem I subunit VII; Region: psaC; CHL00065 373994006178 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373994006179 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373994006180 HSP70 interaction site [polypeptide binding]; other site 373994006181 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994006182 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006183 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006184 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 373994006185 catalytic residues [active] 373994006186 dimer interface [polypeptide binding]; other site 373994006187 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373994006188 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 373994006189 putative NAD(P) binding site [chemical binding]; other site 373994006190 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994006191 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 373994006192 putative catalytic site [active] 373994006193 putative metal binding site [ion binding]; other site 373994006194 putative phosphate binding site [ion binding]; other site 373994006195 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 373994006196 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994006197 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994006198 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994006199 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994006200 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994006201 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994006202 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 373994006203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373994006204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994006205 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 373994006206 putative effector binding pocket; other site 373994006207 dimerization interface [polypeptide binding]; other site 373994006208 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 373994006209 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 373994006210 putative catalytic residues [active] 373994006211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994006212 S-adenosylmethionine binding site [chemical binding]; other site 373994006213 S-layer homology domain; Region: SLH; pfam00395 373994006214 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 373994006215 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 373994006216 dimer interface [polypeptide binding]; other site 373994006217 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373994006218 active site 373994006219 metal binding site [ion binding]; metal-binding site 373994006220 glutathione binding site [chemical binding]; other site 373994006221 TetR family transcriptional regulator; Provisional; Region: PRK14996 373994006222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994006223 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 373994006224 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994006225 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373994006226 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 373994006227 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 373994006228 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 373994006229 N-terminal domain interface [polypeptide binding]; other site 373994006230 YcxB-like protein; Region: YcxB; pfam14317 373994006231 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 373994006232 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994006233 active site 373994006234 ATP binding site [chemical binding]; other site 373994006235 substrate binding site [chemical binding]; other site 373994006236 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 373994006237 Glucose inhibited division protein A; Region: GIDA; pfam01134 373994006238 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 373994006239 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 373994006240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994006241 Coenzyme A binding pocket [chemical binding]; other site 373994006242 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 373994006243 Peptidase family M23; Region: Peptidase_M23; pfam01551 373994006244 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 373994006245 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373994006246 active site 373994006247 metal binding site [ion binding]; metal-binding site 373994006248 Uncharacterized conserved protein [Function unknown]; Region: COG5607 373994006249 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 373994006250 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 373994006251 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 373994006252 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 373994006253 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373994006254 ABC-ATPase subunit interface; other site 373994006255 dimer interface [polypeptide binding]; other site 373994006256 putative PBP binding regions; other site 373994006257 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 373994006258 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 373994006259 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 373994006260 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 373994006261 intersubunit interface [polypeptide binding]; other site 373994006262 S-layer homology domain; Region: SLH; pfam00395 373994006263 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 373994006264 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 373994006265 dimer interface [polypeptide binding]; other site 373994006266 active site 373994006267 aspartate-rich active site metal binding site; other site 373994006268 allosteric magnesium binding site [ion binding]; other site 373994006269 Schiff base residues; other site 373994006270 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 373994006271 homodecamer interface [polypeptide binding]; other site 373994006272 GTP cyclohydrolase I; Provisional; Region: PLN03044 373994006273 active site 373994006274 putative catalytic site residues [active] 373994006275 zinc binding site [ion binding]; other site 373994006276 GTP-CH-I/GFRP interaction surface; other site 373994006277 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994006278 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 373994006279 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 373994006280 active site 373994006281 HIGH motif; other site 373994006282 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 373994006283 KMSKS motif; other site 373994006284 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 373994006285 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 373994006286 Peptidase family M23; Region: Peptidase_M23; pfam01551 373994006287 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 373994006288 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373994006289 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 373994006290 active site 373994006291 metal binding site [ion binding]; metal-binding site 373994006292 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994006293 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 373994006294 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 373994006295 P-loop, Walker A motif; other site 373994006296 Base recognition motif; other site 373994006297 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 373994006298 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994006299 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994006300 structural tetrad; other site 373994006301 Uncharacterized conserved protein [Function unknown]; Region: COG5464 373994006302 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 373994006303 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 373994006304 AAA domain; Region: AAA_11; pfam13086 373994006305 Part of AAA domain; Region: AAA_19; pfam13245 373994006306 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 373994006307 AAA domain; Region: AAA_12; pfam13087 373994006308 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 373994006309 putative active site [active] 373994006310 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 373994006311 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373994006312 dimerization interface [polypeptide binding]; other site 373994006313 putative DNA binding site [nucleotide binding]; other site 373994006314 putative Zn2+ binding site [ion binding]; other site 373994006315 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 373994006316 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 373994006317 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 373994006318 active site 373994006319 dimer interface [polypeptide binding]; other site 373994006320 motif 1; other site 373994006321 motif 2; other site 373994006322 motif 3; other site 373994006323 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 373994006324 anticodon binding site; other site 373994006325 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 373994006326 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 373994006327 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994006328 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 373994006329 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 373994006330 4Fe-4S binding domain; Region: Fer4; pfam00037 373994006331 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 373994006332 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 373994006333 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 373994006334 catalytic residues [active] 373994006335 Domain of unknown function DUF21; Region: DUF21; pfam01595 373994006336 FOG: CBS domain [General function prediction only]; Region: COG0517 373994006337 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 373994006338 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 373994006339 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 373994006340 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 373994006341 cofactor binding site; other site 373994006342 DNA binding site [nucleotide binding] 373994006343 substrate interaction site [chemical binding]; other site 373994006344 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 373994006345 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 373994006346 active site 373994006347 homodimer interface [polypeptide binding]; other site 373994006348 SnoaL-like domain; Region: SnoaL_2; pfam12680 373994006349 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 373994006350 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 373994006351 putative NAD(P) binding site [chemical binding]; other site 373994006352 homodimer interface [polypeptide binding]; other site 373994006353 homotetramer interface [polypeptide binding]; other site 373994006354 active site 373994006355 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 373994006356 non-specific DNA binding site [nucleotide binding]; other site 373994006357 salt bridge; other site 373994006358 sequence-specific DNA binding site [nucleotide binding]; other site 373994006359 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 373994006360 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 373994006361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994006362 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994006363 putative active site [active] 373994006364 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 373994006365 PAS fold; Region: PAS_3; pfam08447 373994006366 PAS domain S-box; Region: sensory_box; TIGR00229 373994006367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994006368 putative active site [active] 373994006369 heme pocket [chemical binding]; other site 373994006370 PAS fold; Region: PAS_4; pfam08448 373994006371 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994006372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994006373 ATP binding site [chemical binding]; other site 373994006374 Mg2+ binding site [ion binding]; other site 373994006375 G-X-G motif; other site 373994006376 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 373994006377 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 373994006378 anti sigma factor interaction site; other site 373994006379 regulatory phosphorylation site [posttranslational modification]; other site 373994006380 Response regulator receiver domain; Region: Response_reg; pfam00072 373994006381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994006382 active site 373994006383 phosphorylation site [posttranslational modification] 373994006384 intermolecular recognition site; other site 373994006385 dimerization interface [polypeptide binding]; other site 373994006386 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 373994006387 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 373994006388 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 373994006389 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994006390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994006391 S-adenosylmethionine binding site [chemical binding]; other site 373994006392 geranylgeranyl reductase; Region: ChlP; TIGR02028 373994006393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373994006394 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 373994006395 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 373994006396 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994006397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994006398 Walker A/P-loop; other site 373994006399 ATP binding site [chemical binding]; other site 373994006400 Q-loop/lid; other site 373994006401 ABC transporter signature motif; other site 373994006402 Walker B; other site 373994006403 D-loop; other site 373994006404 H-loop/switch region; other site 373994006405 haemagglutination activity domain; Region: Haemagg_act; cl05436 373994006406 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994006407 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994006408 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994006409 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994006410 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994006411 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994006412 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994006413 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994006414 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994006415 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994006416 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994006417 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994006418 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994006419 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994006420 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994006421 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994006422 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994006423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 373994006424 binding surface 373994006425 TPR motif; other site 373994006426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 373994006427 TPR motif; other site 373994006428 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994006429 binding surface 373994006430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 373994006431 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994006432 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994006433 CHASE2 domain; Region: CHASE2; pfam05226 373994006434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994006435 dimer interface [polypeptide binding]; other site 373994006436 phosphorylation site [posttranslational modification] 373994006437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994006438 ATP binding site [chemical binding]; other site 373994006439 Mg2+ binding site [ion binding]; other site 373994006440 G-X-G motif; other site 373994006441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994006442 Response regulator receiver domain; Region: Response_reg; pfam00072 373994006443 active site 373994006444 phosphorylation site [posttranslational modification] 373994006445 intermolecular recognition site; other site 373994006446 dimerization interface [polypeptide binding]; other site 373994006447 Response regulator receiver domain; Region: Response_reg; pfam00072 373994006448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994006449 active site 373994006450 phosphorylation site [posttranslational modification] 373994006451 intermolecular recognition site; other site 373994006452 dimerization interface [polypeptide binding]; other site 373994006453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 373994006454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994006455 dimer interface [polypeptide binding]; other site 373994006456 phosphorylation site [posttranslational modification] 373994006457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994006458 ATP binding site [chemical binding]; other site 373994006459 Mg2+ binding site [ion binding]; other site 373994006460 G-X-G motif; other site 373994006461 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 373994006462 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 373994006463 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 373994006464 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 373994006465 RNA binding site [nucleotide binding]; other site 373994006466 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373994006467 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 373994006468 substrate binding site [chemical binding]; other site 373994006469 ATP binding site [chemical binding]; other site 373994006470 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 373994006471 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994006472 catalytic loop [active] 373994006473 iron binding site [ion binding]; other site 373994006474 Predicted membrane protein [Function unknown]; Region: COG1950 373994006475 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 373994006476 Cytochrome c; Region: Cytochrom_C; cl11414 373994006477 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 373994006478 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373994006479 Chain length determinant protein; Region: Wzz; pfam02706 373994006480 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 373994006481 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994006482 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994006483 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 373994006484 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 373994006485 AAA domain; Region: AAA_18; pfam13238 373994006486 ligand-binding site [chemical binding]; other site 373994006487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994006488 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 373994006489 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 373994006490 Walker A/P-loop; other site 373994006491 ATP binding site [chemical binding]; other site 373994006492 Q-loop/lid; other site 373994006493 ABC transporter signature motif; other site 373994006494 Walker B; other site 373994006495 D-loop; other site 373994006496 H-loop/switch region; other site 373994006497 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 373994006498 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 373994006499 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 373994006500 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 373994006501 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 373994006502 trimer interface [polypeptide binding]; other site 373994006503 active site 373994006504 substrate binding site [chemical binding]; other site 373994006505 CoA binding site [chemical binding]; other site 373994006506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994006507 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 373994006508 putative ADP-binding pocket [chemical binding]; other site 373994006509 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 373994006510 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373994006511 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373994006512 active site 373994006513 catalytic tetrad [active] 373994006514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994006515 S-adenosylmethionine binding site [chemical binding]; other site 373994006516 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994006517 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 373994006518 putative metal binding site; other site 373994006519 Uncharacterized conserved protein [Function unknown]; Region: COG1434 373994006520 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 373994006521 putative active site [active] 373994006522 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994006523 putative active site [active] 373994006524 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 373994006525 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 373994006526 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006527 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994006528 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006529 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006530 Predicted permeases [General function prediction only]; Region: COG0701 373994006531 TIGR03943 family protein; Region: TIGR03943 373994006532 Bacterial Ig-like domain; Region: Big_5; pfam13205 373994006533 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 373994006534 Pleckstrin homology-like domain; Region: PH-like; cl17171 373994006535 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 373994006536 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 373994006537 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 373994006538 active site 373994006539 catalytic residues [active] 373994006540 metal binding site [ion binding]; metal-binding site 373994006541 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 373994006542 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 373994006543 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 373994006544 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 373994006545 ThiS interaction site; other site 373994006546 putative active site [active] 373994006547 tetramer interface [polypeptide binding]; other site 373994006548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 373994006549 TPR motif; other site 373994006550 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994006551 binding surface 373994006552 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994006553 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 373994006554 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 373994006555 Uncharacterized conserved protein [Function unknown]; Region: COG1565 373994006556 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 373994006557 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 373994006558 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373994006559 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 373994006560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994006561 S-adenosylmethionine binding site [chemical binding]; other site 373994006562 CheB methylesterase; Region: CheB_methylest; pfam01339 373994006563 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 373994006564 Reverse gyrase [DNA replication, recombination, and repair]; Region: COG1110 373994006565 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 373994006566 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373994006567 Walker A/P-loop; other site 373994006568 ATP binding site [chemical binding]; other site 373994006569 Q-loop/lid; other site 373994006570 ABC transporter signature motif; other site 373994006571 Walker B; other site 373994006572 D-loop; other site 373994006573 H-loop/switch region; other site 373994006574 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 373994006575 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373994006576 Walker A/P-loop; other site 373994006577 ATP binding site [chemical binding]; other site 373994006578 Q-loop/lid; other site 373994006579 ABC transporter signature motif; other site 373994006580 Walker B; other site 373994006581 D-loop; other site 373994006582 H-loop/switch region; other site 373994006583 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 373994006584 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 373994006585 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 373994006586 dimer interface [polypeptide binding]; other site 373994006587 ssDNA binding site [nucleotide binding]; other site 373994006588 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 373994006589 tetramer (dimer of dimers) interface [polypeptide binding]; other site 373994006590 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 373994006591 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 373994006592 Walker A/P-loop; other site 373994006593 ATP binding site [chemical binding]; other site 373994006594 Q-loop/lid; other site 373994006595 ABC transporter signature motif; other site 373994006596 Walker B; other site 373994006597 D-loop; other site 373994006598 H-loop/switch region; other site 373994006599 TOBE domain; Region: TOBE_2; pfam08402 373994006600 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 373994006601 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 373994006602 active site 373994006603 Substrate binding site; other site 373994006604 Mg++ binding site; other site 373994006605 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 373994006606 putative CoA binding site [chemical binding]; other site 373994006607 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 373994006608 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 373994006609 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 373994006610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994006611 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 373994006612 putative ADP-binding pocket [chemical binding]; other site 373994006613 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994006614 DNA repair protein RadA; Provisional; Region: PRK11823 373994006615 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 373994006616 Walker A motif/ATP binding site; other site 373994006617 ATP binding site [chemical binding]; other site 373994006618 Walker B motif; other site 373994006619 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 373994006620 Ycf27; Reviewed; Region: orf27; CHL00148 373994006621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994006622 active site 373994006623 phosphorylation site [posttranslational modification] 373994006624 intermolecular recognition site; other site 373994006625 dimerization interface [polypeptide binding]; other site 373994006626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994006627 DNA binding site [nucleotide binding] 373994006628 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 373994006629 Protein of unknown function (DUF456); Region: DUF456; cl01069 373994006630 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 373994006631 HEAT repeats; Region: HEAT_2; pfam13646 373994006632 HEAT repeats; Region: HEAT_2; pfam13646 373994006633 HEAT repeats; Region: HEAT_2; pfam13646 373994006634 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 373994006635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994006636 Coenzyme A binding pocket [chemical binding]; other site 373994006637 Protein of unknown function (DUF677); Region: DUF677; pfam05055 373994006638 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 373994006639 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 373994006640 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 373994006641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994006642 Walker A/P-loop; other site 373994006643 ATP binding site [chemical binding]; other site 373994006644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994006645 ABC transporter signature motif; other site 373994006646 Walker B; other site 373994006647 D-loop; other site 373994006648 H-loop/switch region; other site 373994006649 hypothetical protein; Provisional; Region: PRK06850 373994006650 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 373994006651 Active Sites [active] 373994006652 DGQHR domain; Region: DGQHR; TIGR03187 373994006653 DNA-sulfur modification-associated; Region: DndB; cl17621 373994006654 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 373994006655 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 373994006656 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 373994006657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994006658 Walker A/P-loop; other site 373994006659 ATP binding site [chemical binding]; other site 373994006660 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 373994006661 Nucleoporin complex subunit 54; Region: Nup54; pfam13874 373994006662 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 373994006663 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994006664 ATP binding site [chemical binding]; other site 373994006665 putative Mg++ binding site [ion binding]; other site 373994006666 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994006667 nucleotide binding region [chemical binding]; other site 373994006668 ATP-binding site [chemical binding]; other site 373994006669 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 373994006670 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 373994006671 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 373994006672 Catalytic site [active] 373994006673 ornithine carbamoyltransferase; Provisional; Region: PRK00779 373994006674 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 373994006675 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 373994006676 GxxExxY protein; Region: GxxExxY; TIGR04256 373994006677 Cupin domain; Region: Cupin_2; pfam07883 373994006678 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 373994006679 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 373994006680 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 373994006681 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 373994006682 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 373994006683 catalytic triad [active] 373994006684 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006685 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994006686 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006687 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994006688 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006689 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006690 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 373994006691 homodecamer interface [polypeptide binding]; other site 373994006692 GTP cyclohydrolase I; Provisional; Region: PLN03044 373994006693 active site 373994006694 putative catalytic site residues [active] 373994006695 zinc binding site [ion binding]; other site 373994006696 GTP-CH-I/GFRP interaction surface; other site 373994006697 RDD family; Region: RDD; pfam06271 373994006698 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994006699 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006700 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006701 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006702 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006703 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994006704 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994006705 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994006706 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 373994006707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 373994006708 Mg2+ binding site [ion binding]; other site 373994006709 G-X-G motif; other site 373994006710 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 373994006711 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 373994006712 interchain domain interface [polypeptide binding]; other site 373994006713 intrachain domain interface; other site 373994006714 Qi binding site; other site 373994006715 Qo binding site; other site 373994006716 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 373994006717 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 373994006718 Qi binding site; other site 373994006719 intrachain domain interface; other site 373994006720 interchain domain interface [polypeptide binding]; other site 373994006721 heme bH binding site [chemical binding]; other site 373994006722 heme bL binding site [chemical binding]; other site 373994006723 Qo binding site; other site 373994006724 carboxyl-terminal processing protease; Provisional; Region: PLN00049 373994006725 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 373994006726 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 373994006727 protein binding site [polypeptide binding]; other site 373994006728 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 373994006729 Catalytic dyad [active] 373994006730 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 373994006731 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 373994006732 Peptidase family M50; Region: Peptidase_M50; pfam02163 373994006733 active site 373994006734 putative substrate binding region [chemical binding]; other site 373994006735 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 373994006736 CpeS-like protein; Region: CpeS; pfam09367 373994006737 HEAT repeats; Region: HEAT_2; pfam13646 373994006738 HEAT repeats; Region: HEAT_2; pfam13646 373994006739 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 373994006740 HEAT repeats; Region: HEAT_2; pfam13646 373994006741 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 373994006742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994006743 putative substrate translocation pore; other site 373994006744 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 373994006745 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373994006746 active site 373994006747 Predicted permeases [General function prediction only]; Region: COG0679 373994006748 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 373994006749 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 373994006750 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994006751 putative active site [active] 373994006752 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782 373994006753 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl11892 373994006754 CRISPR/Cas system-associated protein Cas8c' Region: Cas8c'_I-D; cl11893 373994006755 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 373994006756 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 373994006757 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 373994006758 DEAD-like helicases superfamily; Region: DEXDc; smart00487 373994006759 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994006760 ATP binding site [chemical binding]; other site 373994006761 putative Mg++ binding site [ion binding]; other site 373994006762 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 373994006763 Uncharacterized conserved protein [Function unknown]; Region: COG3472 373994006764 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 373994006765 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 373994006766 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 373994006767 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 373994006768 HsdM N-terminal domain; Region: HsdM_N; pfam12161 373994006769 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 373994006770 TniQ; Region: TniQ; pfam06527 373994006771 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 373994006772 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 373994006773 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 373994006774 putative active site [active] 373994006775 putative NTP binding site [chemical binding]; other site 373994006776 putative nucleic acid binding site [nucleotide binding]; other site 373994006777 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 373994006778 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 373994006779 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 373994006780 active site 373994006781 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 373994006782 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 373994006783 substrate binding site [chemical binding]; other site 373994006784 glutamase interaction surface [polypeptide binding]; other site 373994006785 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 373994006786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994006787 Walker A motif; other site 373994006788 ATP binding site [chemical binding]; other site 373994006789 Walker B motif; other site 373994006790 arginine finger; other site 373994006791 Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; Region: PI3Ka; cl00271 373994006792 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 373994006793 TPR repeat; Region: TPR_11; pfam13414 373994006794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994006795 binding surface 373994006796 TPR motif; other site 373994006797 TPR repeat; Region: TPR_11; pfam13414 373994006798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994006799 binding surface 373994006800 TPR motif; other site 373994006801 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 373994006802 GDP-Fucose binding site [chemical binding]; other site 373994006803 peptide synthase; Provisional; Region: PRK12467 373994006804 acyltransferase PapA5; Provisional; Region: PRK09294 373994006805 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 373994006806 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 373994006807 hypothetical protein; Provisional; Region: PRK02724 373994006808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 373994006809 Uncharacterized conserved protein [Function unknown]; Region: COG5439 373994006810 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 373994006811 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 373994006812 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 373994006813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 373994006814 Uncharacterized conserved protein [Function unknown]; Region: COG5439 373994006815 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 373994006816 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 373994006817 gamma subunit interface [polypeptide binding]; other site 373994006818 epsilon subunit interface [polypeptide binding]; other site 373994006819 LBP interface [polypeptide binding]; other site 373994006820 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 373994006821 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 373994006822 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 373994006823 alpha subunit interaction interface [polypeptide binding]; other site 373994006824 Walker A motif; other site 373994006825 ATP binding site [chemical binding]; other site 373994006826 Walker B motif; other site 373994006827 inhibitor binding site; inhibition site 373994006828 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 373994006829 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 373994006830 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373994006831 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373994006832 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 373994006833 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994006834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994006835 Walker A/P-loop; other site 373994006836 ATP binding site [chemical binding]; other site 373994006837 Q-loop/lid; other site 373994006838 ABC transporter signature motif; other site 373994006839 Walker B; other site 373994006840 D-loop; other site 373994006841 H-loop/switch region; other site 373994006842 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 373994006843 catalytic core [active] 373994006844 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373994006845 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 373994006846 putative NAD(P) binding site [chemical binding]; other site 373994006847 active site 373994006848 putative substrate binding site [chemical binding]; other site 373994006849 Response regulator receiver domain; Region: Response_reg; pfam00072 373994006850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994006851 active site 373994006852 phosphorylation site [posttranslational modification] 373994006853 intermolecular recognition site; other site 373994006854 dimerization interface [polypeptide binding]; other site 373994006855 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 373994006856 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 373994006857 NodB motif; other site 373994006858 active site 373994006859 catalytic site [active] 373994006860 metal binding site [ion binding]; metal-binding site 373994006861 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994006862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994006863 active site 373994006864 phosphorylation site [posttranslational modification] 373994006865 intermolecular recognition site; other site 373994006866 dimerization interface [polypeptide binding]; other site 373994006867 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994006868 DNA binding site [nucleotide binding] 373994006869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994006870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994006871 dimerization interface [polypeptide binding]; other site 373994006872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994006873 dimer interface [polypeptide binding]; other site 373994006874 phosphorylation site [posttranslational modification] 373994006875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994006876 ATP binding site [chemical binding]; other site 373994006877 Mg2+ binding site [ion binding]; other site 373994006878 G-X-G motif; other site 373994006879 Uncharacterized conserved protein [Function unknown]; Region: COG2912 373994006880 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 373994006881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 373994006882 TPR motif; other site 373994006883 binding surface 373994006884 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 373994006885 hydrophobic ligand binding site; other site 373994006886 Conserved TM helix; Region: TM_helix; pfam05552 373994006887 Conserved TM helix; Region: TM_helix; pfam05552 373994006888 Conserved TM helix; Region: TM_helix; pfam05552 373994006889 Conserved TM helix; Region: TM_helix; pfam05552 373994006890 Dynamin family; Region: Dynamin_N; pfam00350 373994006891 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 373994006892 G1 box; other site 373994006893 GTP/Mg2+ binding site [chemical binding]; other site 373994006894 Switch I region; other site 373994006895 G2 box; other site 373994006896 Switch II region; other site 373994006897 G3 box; other site 373994006898 G4 box; other site 373994006899 G5 box; other site 373994006900 Domain of unknown function (DUF697); Region: DUF697; pfam05128 373994006901 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 373994006902 triosephosphate isomerase; Provisional; Region: PRK14565 373994006903 substrate binding site [chemical binding]; other site 373994006904 dimer interface [polypeptide binding]; other site 373994006905 catalytic triad [active] 373994006906 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 373994006907 dihydropteroate synthase; Region: DHPS; TIGR01496 373994006908 substrate binding pocket [chemical binding]; other site 373994006909 dimer interface [polypeptide binding]; other site 373994006910 inhibitor binding site; inhibition site 373994006911 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 373994006912 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 373994006913 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 373994006914 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 373994006915 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 373994006916 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 373994006917 SLBB domain; Region: SLBB; pfam10531 373994006918 SLBB domain; Region: SLBB; pfam10531 373994006919 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 373994006920 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 373994006921 Walker A/P-loop; other site 373994006922 ATP binding site [chemical binding]; other site 373994006923 Q-loop/lid; other site 373994006924 ABC transporter signature motif; other site 373994006925 Walker B; other site 373994006926 D-loop; other site 373994006927 H-loop/switch region; other site 373994006928 Beta-lactamase; Region: Beta-lactamase; pfam00144 373994006929 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 373994006930 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994006931 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994006932 structural tetrad; other site 373994006933 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994006934 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994006935 structural tetrad; other site 373994006936 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 373994006937 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 373994006938 putative active site pocket [active] 373994006939 4-fold oligomerization interface [polypeptide binding]; other site 373994006940 metal binding residues [ion binding]; metal-binding site 373994006941 3-fold/trimer interface [polypeptide binding]; other site 373994006942 Response regulator receiver domain; Region: Response_reg; pfam00072 373994006943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994006944 active site 373994006945 phosphorylation site [posttranslational modification] 373994006946 intermolecular recognition site; other site 373994006947 dimerization interface [polypeptide binding]; other site 373994006948 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994006949 GAF domain; Region: GAF; pfam01590 373994006950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994006951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994006952 dimer interface [polypeptide binding]; other site 373994006953 phosphorylation site [posttranslational modification] 373994006954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994006955 ATP binding site [chemical binding]; other site 373994006956 Mg2+ binding site [ion binding]; other site 373994006957 G-X-G motif; other site 373994006958 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 373994006959 CheB methylesterase; Region: CheB_methylest; pfam01339 373994006960 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 373994006961 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 373994006962 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 373994006963 PAS domain; Region: PAS_10; pfam13596 373994006964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994006965 PAS fold; Region: PAS_4; pfam08448 373994006966 putative active site [active] 373994006967 heme pocket [chemical binding]; other site 373994006968 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994006969 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994006970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994006971 dimer interface [polypeptide binding]; other site 373994006972 phosphorylation site [posttranslational modification] 373994006973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994006974 ATP binding site [chemical binding]; other site 373994006975 Mg2+ binding site [ion binding]; other site 373994006976 G-X-G motif; other site 373994006977 Response regulator receiver domain; Region: Response_reg; pfam00072 373994006978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994006979 active site 373994006980 phosphorylation site [posttranslational modification] 373994006981 intermolecular recognition site; other site 373994006982 dimerization interface [polypeptide binding]; other site 373994006983 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 373994006984 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 373994006985 NAD binding site [chemical binding]; other site 373994006986 homotetramer interface [polypeptide binding]; other site 373994006987 homodimer interface [polypeptide binding]; other site 373994006988 substrate binding site [chemical binding]; other site 373994006989 active site 373994006990 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994006991 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 373994006992 ligand binding site [chemical binding]; other site 373994006993 flexible hinge region; other site 373994006994 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 373994006995 putative switch regulator; other site 373994006996 non-specific DNA interactions [nucleotide binding]; other site 373994006997 DNA binding site [nucleotide binding] 373994006998 sequence specific DNA binding site [nucleotide binding]; other site 373994006999 putative cAMP binding site [chemical binding]; other site 373994007000 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 373994007001 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 373994007002 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 373994007003 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 373994007004 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 373994007005 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 373994007006 RNase E interface [polypeptide binding]; other site 373994007007 trimer interface [polypeptide binding]; other site 373994007008 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 373994007009 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 373994007010 RNase E interface [polypeptide binding]; other site 373994007011 trimer interface [polypeptide binding]; other site 373994007012 active site 373994007013 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 373994007014 putative nucleic acid binding region [nucleotide binding]; other site 373994007015 G-X-X-G motif; other site 373994007016 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 373994007017 RNA binding site [nucleotide binding]; other site 373994007018 domain interface; other site 373994007019 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 373994007020 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 373994007021 Coenzyme A binding pocket [chemical binding]; other site 373994007022 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 373994007023 SNF2 Helicase protein; Region: DUF3670; pfam12419 373994007024 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 373994007025 protein-splicing catalytic site; other site 373994007026 thioester formation/cholesterol transfer; other site 373994007027 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 373994007028 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 373994007029 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994007030 putative Mg++ binding site [ion binding]; other site 373994007031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994007032 nucleotide binding region [chemical binding]; other site 373994007033 ATP-binding site [chemical binding]; other site 373994007034 Uncharacterized conserved protein [Function unknown]; Region: COG4279 373994007035 photosystem II 44 kDa protein; Region: psbC; CHL00035 373994007036 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 373994007037 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 373994007038 D1 interface; other site 373994007039 chlorophyll binding site; other site 373994007040 pheophytin binding site; other site 373994007041 beta carotene binding site; other site 373994007042 cytochrome b559 beta interface; other site 373994007043 quinone binding site; other site 373994007044 cytochrome b559 alpha interface; other site 373994007045 protein J interface; other site 373994007046 protein H interface; other site 373994007047 protein X interface; other site 373994007048 core light harvesting protein interface; other site 373994007049 protein L interface; other site 373994007050 CP43 interface; other site 373994007051 protein T interface; other site 373994007052 Fe binding site [ion binding]; other site 373994007053 protein M interface; other site 373994007054 Mn-stabilizing polypeptide interface; other site 373994007055 bromide binding site; other site 373994007056 cytochrome c-550 interface; other site 373994007057 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 373994007058 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 373994007059 active site 373994007060 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 373994007061 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 373994007062 dimer interface [polypeptide binding]; other site 373994007063 active site 373994007064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994007065 BT1 family; Region: BT1; pfam03092 373994007066 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 373994007067 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 373994007068 HEAT repeats; Region: HEAT_2; pfam13646 373994007069 HEAT repeats; Region: HEAT_2; pfam13646 373994007070 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 373994007071 protein binding surface [polypeptide binding]; other site 373994007072 HEAT repeats; Region: HEAT_2; pfam13646 373994007073 HEAT repeats; Region: HEAT_2; pfam13646 373994007074 HEAT repeats; Region: HEAT_2; pfam13646 373994007075 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 373994007076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994007077 FeS/SAM binding site; other site 373994007078 HemN C-terminal domain; Region: HemN_C; pfam06969 373994007079 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 373994007080 heme binding pocket [chemical binding]; other site 373994007081 heme ligand [chemical binding]; other site 373994007082 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 373994007083 diiron binding motif [ion binding]; other site 373994007084 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994007085 Cytochrome P450; Region: p450; pfam00067 373994007086 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 373994007087 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 373994007088 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 373994007089 NAD(P) binding site [chemical binding]; other site 373994007090 Bacterial SH3 domain; Region: SH3_3; cl17532 373994007091 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 373994007092 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 373994007093 PemK-like protein; Region: PemK; pfam02452 373994007094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 373994007095 septum formation inhibitor; Reviewed; Region: minC; PRK00513 373994007096 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 373994007097 septum site-determining protein MinD; Region: minD_bact; TIGR01968 373994007098 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 373994007099 Switch I; other site 373994007100 Switch II; other site 373994007101 cell division topological specificity factor MinE; Provisional; Region: PRK13988 373994007102 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 373994007103 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 373994007104 putative active site [active] 373994007105 substrate binding site [chemical binding]; other site 373994007106 putative cosubstrate binding site; other site 373994007107 catalytic site [active] 373994007108 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 373994007109 substrate binding site [chemical binding]; other site 373994007110 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 373994007111 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 373994007112 homotetramer interface [polypeptide binding]; other site 373994007113 ligand binding site [chemical binding]; other site 373994007114 catalytic site [active] 373994007115 NAD binding site [chemical binding]; other site 373994007116 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373994007117 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994007118 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994007119 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994007120 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994007121 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994007122 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 373994007123 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 373994007124 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 373994007125 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 373994007126 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 373994007127 catalytic residues [active] 373994007128 Recombinase; Region: Recombinase; pfam07508 373994007129 FOG: CBS domain [General function prediction only]; Region: COG0517 373994007130 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 373994007131 FOG: CBS domain [General function prediction only]; Region: COG0517 373994007132 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 373994007133 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 373994007134 MgtE intracellular N domain; Region: MgtE_N; smart00924 373994007135 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 373994007136 Divalent cation transporter; Region: MgtE; pfam01769 373994007137 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 373994007138 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 373994007139 Uncharacterized conserved protein [Function unknown]; Region: COG5464 373994007140 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994007141 active site 373994007142 Uncharacterized conserved protein [Function unknown]; Region: COG3339 373994007143 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 373994007144 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 373994007145 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 373994007146 Predicted membrane protein [Function unknown]; Region: COG1950 373994007147 Thf1-like protein; Reviewed; Region: PRK13266 373994007148 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 373994007149 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 373994007150 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 373994007151 anti sigma factor interaction site; other site 373994007152 regulatory phosphorylation site [posttranslational modification]; other site 373994007153 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 373994007154 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 373994007155 antiporter inner membrane protein; Provisional; Region: PRK11670 373994007156 Domain of unknown function DUF59; Region: DUF59; pfam01883 373994007157 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 373994007158 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 373994007159 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 373994007160 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 373994007161 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 373994007162 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 373994007163 Ligand Binding Site [chemical binding]; other site 373994007164 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994007165 Ligand Binding Site [chemical binding]; other site 373994007166 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373994007167 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 373994007168 NAD binding site [chemical binding]; other site 373994007169 putative substrate binding site 2 [chemical binding]; other site 373994007170 putative substrate binding site 1 [chemical binding]; other site 373994007171 active site 373994007172 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 373994007173 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 373994007174 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 373994007175 amino acid transporter; Region: 2A0306; TIGR00909 373994007176 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 373994007177 competence damage-inducible protein A; Provisional; Region: PRK00549 373994007178 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 373994007179 putative MPT binding site; other site 373994007180 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 373994007181 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 373994007182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994007183 ATP binding site [chemical binding]; other site 373994007184 Mg2+ binding site [ion binding]; other site 373994007185 G-X-G motif; other site 373994007186 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 373994007187 ATP binding site [chemical binding]; other site 373994007188 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 373994007189 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 373994007190 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 373994007191 active site 373994007192 CHASE3 domain; Region: CHASE3; pfam05227 373994007193 PAS domain S-box; Region: sensory_box; TIGR00229 373994007194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994007195 putative active site [active] 373994007196 heme pocket [chemical binding]; other site 373994007197 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 373994007198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994007199 putative active site [active] 373994007200 heme pocket [chemical binding]; other site 373994007201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994007202 dimer interface [polypeptide binding]; other site 373994007203 phosphorylation site [posttranslational modification] 373994007204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994007205 ATP binding site [chemical binding]; other site 373994007206 Mg2+ binding site [ion binding]; other site 373994007207 G-X-G motif; other site 373994007208 Response regulator receiver domain; Region: Response_reg; pfam00072 373994007209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994007210 active site 373994007211 phosphorylation site [posttranslational modification] 373994007212 intermolecular recognition site; other site 373994007213 dimerization interface [polypeptide binding]; other site 373994007214 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 373994007215 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 373994007216 GDP-binding site [chemical binding]; other site 373994007217 ACT binding site; other site 373994007218 IMP binding site; other site 373994007219 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 373994007220 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 373994007221 5S rRNA interface [nucleotide binding]; other site 373994007222 CTC domain interface [polypeptide binding]; other site 373994007223 L16 interface [polypeptide binding]; other site 373994007224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 373994007225 Ecdysteroid kinase; Region: EcKinase; cl17738 373994007226 Predicted kinase [General function prediction only]; Region: COG0645 373994007227 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 373994007228 ATP-binding site [chemical binding]; other site 373994007229 Gluconate-6-phosphate binding site [chemical binding]; other site 373994007230 Uncharacterized conserved protein [Function unknown]; Region: COG1434 373994007231 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 373994007232 putative active site [active] 373994007233 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 373994007234 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 373994007235 Protein phosphatase 2C; Region: PP2C; pfam00481 373994007236 active site 373994007237 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 373994007238 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 373994007239 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 373994007240 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 373994007241 metal binding site 2 [ion binding]; metal-binding site 373994007242 putative DNA binding helix; other site 373994007243 metal binding site 1 [ion binding]; metal-binding site 373994007244 dimer interface [polypeptide binding]; other site 373994007245 structural Zn2+ binding site [ion binding]; other site 373994007246 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 373994007247 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 373994007248 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 373994007249 putative active site [active] 373994007250 catalytic triad [active] 373994007251 CHAT domain; Region: CHAT; cl17868 373994007252 AAA ATPase domain; Region: AAA_16; pfam13191 373994007253 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994007254 structural tetrad; other site 373994007255 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994007256 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994007257 structural tetrad; other site 373994007258 Domain of unknown function (DUF955); Region: DUF955; pfam06114 373994007259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994007260 non-specific DNA binding site [nucleotide binding]; other site 373994007261 salt bridge; other site 373994007262 sequence-specific DNA binding site [nucleotide binding]; other site 373994007263 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 373994007264 5' RNA guide strand anchoring site; other site 373994007265 active site 373994007266 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994007267 putative active site [active] 373994007268 PsaD; Region: PsaD; pfam02531 373994007269 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 373994007270 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994007271 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994007272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994007273 dimer interface [polypeptide binding]; other site 373994007274 phosphorylation site [posttranslational modification] 373994007275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994007276 ATP binding site [chemical binding]; other site 373994007277 Mg2+ binding site [ion binding]; other site 373994007278 G-X-G motif; other site 373994007279 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994007280 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 373994007281 putative ADP-binding pocket [chemical binding]; other site 373994007282 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 373994007283 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 373994007284 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 373994007285 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 373994007286 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 373994007287 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 373994007288 active site 373994007289 dimer interface [polypeptide binding]; other site 373994007290 motif 1; other site 373994007291 motif 2; other site 373994007292 motif 3; other site 373994007293 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 373994007294 anticodon binding site; other site 373994007295 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 373994007296 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 373994007297 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373994007298 homoserine kinase; Provisional; Region: PRK01212 373994007299 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 373994007300 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 373994007301 Ycf46; Provisional; Region: ycf46; CHL00195 373994007302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994007303 Walker A motif; other site 373994007304 ATP binding site [chemical binding]; other site 373994007305 Walker B motif; other site 373994007306 arginine finger; other site 373994007307 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 373994007308 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373994007309 NAD binding site [chemical binding]; other site 373994007310 substrate binding site [chemical binding]; other site 373994007311 active site 373994007312 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994007313 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 373994007314 GAF domain; Region: GAF_2; pfam13185 373994007315 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994007316 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994007317 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994007318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994007319 putative active site [active] 373994007320 heme pocket [chemical binding]; other site 373994007321 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 373994007322 cyclase homology domain; Region: CHD; cd07302 373994007323 nucleotidyl binding site; other site 373994007324 metal binding site [ion binding]; metal-binding site 373994007325 dimer interface [polypeptide binding]; other site 373994007326 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 373994007327 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 373994007328 ATP binding site [chemical binding]; other site 373994007329 active site 373994007330 substrate binding site [chemical binding]; other site 373994007331 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 373994007332 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 373994007333 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 373994007334 Surface antigen; Region: Bac_surface_Ag; pfam01103 373994007335 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 373994007336 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 373994007337 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 373994007338 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 373994007339 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 373994007340 active site 373994007341 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 373994007342 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 373994007343 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373994007344 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373994007345 active site 373994007346 catalytic tetrad [active] 373994007347 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373994007348 G1 box; other site 373994007349 GTP/Mg2+ binding site [chemical binding]; other site 373994007350 G2 box; other site 373994007351 G3 box; other site 373994007352 Switch II region; other site 373994007353 G4 box; other site 373994007354 G5 box; other site 373994007355 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 373994007356 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 373994007357 active site residue [active] 373994007358 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 373994007359 Active_site [active] 373994007360 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994007361 phosphopeptide binding site; other site 373994007362 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994007363 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 373994007364 phosphopeptide binding site; other site 373994007365 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 373994007366 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 373994007367 active site 373994007368 catalytic triad [active] 373994007369 oxyanion hole [active] 373994007370 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 373994007371 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 373994007372 Ca2+ binding site [ion binding]; other site 373994007373 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 373994007374 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 373994007375 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 373994007376 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 373994007377 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 373994007378 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 373994007379 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 373994007380 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 373994007381 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 373994007382 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 373994007383 putative translocon binding site; other site 373994007384 protein-rRNA interface [nucleotide binding]; other site 373994007385 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 373994007386 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 373994007387 G-X-X-G motif; other site 373994007388 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 373994007389 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 373994007390 23S rRNA interface [nucleotide binding]; other site 373994007391 5S rRNA interface [nucleotide binding]; other site 373994007392 putative antibiotic binding site [chemical binding]; other site 373994007393 L25 interface [polypeptide binding]; other site 373994007394 L27 interface [polypeptide binding]; other site 373994007395 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 373994007396 23S rRNA interface [nucleotide binding]; other site 373994007397 putative translocon interaction site; other site 373994007398 signal recognition particle (SRP54) interaction site; other site 373994007399 L23 interface [polypeptide binding]; other site 373994007400 trigger factor interaction site; other site 373994007401 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 373994007402 ribosomal protein L14; Region: rpl14; CHL00057 373994007403 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 373994007404 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 373994007405 RNA binding site [nucleotide binding]; other site 373994007406 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 373994007407 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 373994007408 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 373994007409 ribosomal protein S8; Region: rps8; CHL00042 373994007410 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 373994007411 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 373994007412 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 373994007413 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 373994007414 23S rRNA interface [nucleotide binding]; other site 373994007415 L21e interface [polypeptide binding]; other site 373994007416 5S rRNA interface [nucleotide binding]; other site 373994007417 L27 interface [polypeptide binding]; other site 373994007418 L5 interface [polypeptide binding]; other site 373994007419 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 373994007420 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 373994007421 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 373994007422 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 373994007423 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 373994007424 SecY translocase; Region: SecY; pfam00344 373994007425 adenylate kinase; Provisional; Region: adk; PRK02496 373994007426 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 373994007427 AMP-binding site [chemical binding]; other site 373994007428 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 373994007429 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 373994007430 rRNA binding site [nucleotide binding]; other site 373994007431 predicted 30S ribosome binding site; other site 373994007432 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 373994007433 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 373994007434 30S ribosomal protein S13; Region: bact_S13; TIGR03631 373994007435 30S ribosomal protein S11; Validated; Region: PRK05309 373994007436 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 373994007437 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 373994007438 alphaNTD - beta interaction site [polypeptide binding]; other site 373994007439 alphaNTD homodimer interface [polypeptide binding]; other site 373994007440 alphaNTD - beta' interaction site [polypeptide binding]; other site 373994007441 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 373994007442 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 373994007443 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 373994007444 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 373994007445 dimerization interface 3.5A [polypeptide binding]; other site 373994007446 active site 373994007447 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 373994007448 23S rRNA interface [nucleotide binding]; other site 373994007449 L3 interface [polypeptide binding]; other site 373994007450 ribosomal protein S9; Region: rps9; CHL00079 373994007451 ribosomal protein L31; Validated; Region: rpl31; CHL00136 373994007452 peptide chain release factor 1; Validated; Region: prfA; PRK00591 373994007453 This domain is found in peptide chain release factors; Region: PCRF; smart00937 373994007454 RF-1 domain; Region: RF-1; pfam00472 373994007455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994007456 non-specific DNA binding site [nucleotide binding]; other site 373994007457 salt bridge; other site 373994007458 sequence-specific DNA binding site [nucleotide binding]; other site 373994007459 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994007460 salt bridge; other site 373994007461 non-specific DNA binding site [nucleotide binding]; other site 373994007462 sequence-specific DNA binding site [nucleotide binding]; other site 373994007463 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 373994007464 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 373994007465 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 373994007466 ABC transporter; Region: ABC_tran_2; pfam12848 373994007467 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 373994007468 phosphoglyceromutase; Provisional; Region: PRK05434 373994007469 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 373994007470 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 373994007471 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 373994007472 active site 373994007473 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007474 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994007475 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007476 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007477 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994007478 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007479 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 373994007480 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 373994007481 minor groove reading motif; other site 373994007482 helix-hairpin-helix signature motif; other site 373994007483 substrate binding pocket [chemical binding]; other site 373994007484 active site 373994007485 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 373994007486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994007487 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994007488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994007489 H+ Antiporter protein; Region: 2A0121; TIGR00900 373994007490 putative substrate translocation pore; other site 373994007491 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 373994007492 Recombination protein O N terminal; Region: RecO_N; pfam11967 373994007493 Recombination protein O C terminal; Region: RecO_C; pfam02565 373994007494 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 373994007495 intersubunit interface [polypeptide binding]; other site 373994007496 active site 373994007497 catalytic residue [active] 373994007498 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373994007499 GTP/Mg2+ binding site [chemical binding]; other site 373994007500 G1 box; other site 373994007501 G3 box; other site 373994007502 Switch II region; other site 373994007503 G4 box; other site 373994007504 G5 box; other site 373994007505 Domain of unknown function (DUF697); Region: DUF697; pfam05128 373994007506 L-asparaginase II; Region: Asparaginase_II; cl01842 373994007507 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 373994007508 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 373994007509 putative glycosyl transferase; Provisional; Region: PRK10307 373994007510 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 373994007511 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 373994007512 anti sigma factor interaction site; other site 373994007513 regulatory phosphorylation site [posttranslational modification]; other site 373994007514 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 373994007515 Bacterial sugar transferase; Region: Bac_transf; pfam02397 373994007516 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 373994007517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994007518 FeS/SAM binding site; other site 373994007519 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 373994007520 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994007521 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373994007522 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 373994007523 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 373994007524 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 373994007525 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 373994007526 P-loop; other site 373994007527 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 373994007528 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 373994007529 Clp amino terminal domain; Region: Clp_N; pfam02861 373994007530 Clp amino terminal domain; Region: Clp_N; pfam02861 373994007531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994007532 Walker A motif; other site 373994007533 ATP binding site [chemical binding]; other site 373994007534 Walker B motif; other site 373994007535 arginine finger; other site 373994007536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994007537 Walker A motif; other site 373994007538 ATP binding site [chemical binding]; other site 373994007539 Walker B motif; other site 373994007540 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 373994007541 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994007542 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994007543 active site 373994007544 ATP binding site [chemical binding]; other site 373994007545 substrate binding site [chemical binding]; other site 373994007546 activation loop (A-loop); other site 373994007547 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994007548 phosphopeptide binding site; other site 373994007549 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 373994007550 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 373994007551 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 373994007552 hydrophobic ligand binding site; other site 373994007553 flavoprotein, HI0933 family; Region: TIGR00275 373994007554 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 373994007555 Protein of unknown function, DUF479; Region: DUF479; cl01203 373994007556 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 373994007557 PHP domain; Region: PHP; pfam02811 373994007558 active site 373994007559 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 373994007560 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 373994007561 dimerization interface [polypeptide binding]; other site 373994007562 putative ATP binding site [chemical binding]; other site 373994007563 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 373994007564 Catalytic site [active] 373994007565 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 373994007566 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 373994007567 Pantoate-beta-alanine ligase; Region: PanC; cd00560 373994007568 active site 373994007569 ATP-binding site [chemical binding]; other site 373994007570 pantoate-binding site; other site 373994007571 HXXH motif; other site 373994007572 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 373994007573 CMP-binding site; other site 373994007574 The sites determining sugar specificity; other site 373994007575 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 373994007576 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 373994007577 S-layer homology domain; Region: SLH; pfam00395 373994007578 S-layer homology domain; Region: SLH; pfam00395 373994007579 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 373994007580 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 373994007581 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 373994007582 Nucleoside recognition; Region: Gate; pfam07670 373994007583 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 373994007584 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994007585 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994007586 active site 373994007587 ATP binding site [chemical binding]; other site 373994007588 substrate binding site [chemical binding]; other site 373994007589 activation loop (A-loop); other site 373994007590 AAA ATPase domain; Region: AAA_16; pfam13191 373994007591 Predicted ATPase [General function prediction only]; Region: COG3899 373994007592 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994007593 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994007594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994007595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994007596 dimer interface [polypeptide binding]; other site 373994007597 phosphorylation site [posttranslational modification] 373994007598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994007599 ATP binding site [chemical binding]; other site 373994007600 Mg2+ binding site [ion binding]; other site 373994007601 G-X-G motif; other site 373994007602 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994007603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 373994007604 active site 373994007605 phosphorylation site [posttranslational modification] 373994007606 intermolecular recognition site; other site 373994007607 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994007608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 373994007609 dimer interface [polypeptide binding]; other site 373994007610 phosphorylation site [posttranslational modification] 373994007611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994007612 ATP binding site [chemical binding]; other site 373994007613 Mg2+ binding site [ion binding]; other site 373994007614 G-X-G motif; other site 373994007615 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 373994007616 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 373994007617 active site 373994007618 putative substrate binding pocket [chemical binding]; other site 373994007619 Isochorismatase family; Region: Isochorismatase; pfam00857 373994007620 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 373994007621 catalytic triad [active] 373994007622 conserved cis-peptide bond; other site 373994007623 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 373994007624 Transposase IS200 like; Region: Y1_Tnp; cl00848 373994007625 aspartate kinase; Provisional; Region: PRK07431 373994007626 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 373994007627 putative nucleotide binding site [chemical binding]; other site 373994007628 putative catalytic residues [active] 373994007629 putative Mg ion binding site [ion binding]; other site 373994007630 putative aspartate binding site [chemical binding]; other site 373994007631 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 373994007632 putative allosteric regulatory site; other site 373994007633 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 373994007634 putative allosteric regulatory residue; other site 373994007635 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 373994007636 putative allosteric regulatory site; other site 373994007637 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 373994007638 putative allosteric regulatory residue; other site 373994007639 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994007640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994007641 active site 373994007642 phosphorylation site [posttranslational modification] 373994007643 intermolecular recognition site; other site 373994007644 dimerization interface [polypeptide binding]; other site 373994007645 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994007646 DNA binding residues [nucleotide binding] 373994007647 dimerization interface [polypeptide binding]; other site 373994007648 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994007649 PAS domain; Region: PAS_9; pfam13426 373994007650 putative active site [active] 373994007651 heme pocket [chemical binding]; other site 373994007652 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 373994007653 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994007654 putative active site [active] 373994007655 heme pocket [chemical binding]; other site 373994007656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994007657 heme pocket [chemical binding]; other site 373994007658 putative active site [active] 373994007659 PAS domain S-box; Region: sensory_box; TIGR00229 373994007660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994007661 putative active site [active] 373994007662 heme pocket [chemical binding]; other site 373994007663 PAS domain S-box; Region: sensory_box; TIGR00229 373994007664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994007665 putative active site [active] 373994007666 heme pocket [chemical binding]; other site 373994007667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994007668 dimer interface [polypeptide binding]; other site 373994007669 phosphorylation site [posttranslational modification] 373994007670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994007671 ATP binding site [chemical binding]; other site 373994007672 Mg2+ binding site [ion binding]; other site 373994007673 G-X-G motif; other site 373994007674 CHASE3 domain; Region: CHASE3; pfam05227 373994007675 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 373994007676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994007677 putative active site [active] 373994007678 heme pocket [chemical binding]; other site 373994007679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994007680 dimer interface [polypeptide binding]; other site 373994007681 phosphorylation site [posttranslational modification] 373994007682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994007683 ATP binding site [chemical binding]; other site 373994007684 Mg2+ binding site [ion binding]; other site 373994007685 G-X-G motif; other site 373994007686 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994007687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994007688 active site 373994007689 phosphorylation site [posttranslational modification] 373994007690 intermolecular recognition site; other site 373994007691 dimerization interface [polypeptide binding]; other site 373994007692 Response regulator receiver domain; Region: Response_reg; pfam00072 373994007693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994007694 active site 373994007695 phosphorylation site [posttranslational modification] 373994007696 intermolecular recognition site; other site 373994007697 dimerization interface [polypeptide binding]; other site 373994007698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994007699 dimer interface [polypeptide binding]; other site 373994007700 phosphorylation site [posttranslational modification] 373994007701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994007702 ATP binding site [chemical binding]; other site 373994007703 Mg2+ binding site [ion binding]; other site 373994007704 G-X-G motif; other site 373994007705 Response regulator receiver domain; Region: Response_reg; pfam00072 373994007706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994007707 active site 373994007708 phosphorylation site [posttranslational modification] 373994007709 intermolecular recognition site; other site 373994007710 dimerization interface [polypeptide binding]; other site 373994007711 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994007712 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994007713 dimer interface [polypeptide binding]; other site 373994007714 phosphorylation site [posttranslational modification] 373994007715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994007716 ATP binding site [chemical binding]; other site 373994007717 Mg2+ binding site [ion binding]; other site 373994007718 G-X-G motif; other site 373994007719 Probable transposase; Region: OrfB_IS605; pfam01385 373994007720 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 373994007721 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994007722 Predicted membrane protein [Function unknown]; Region: COG2261 373994007723 CsbD-like; Region: CsbD; cl17424 373994007724 glucose-1-dehydrogenase; Provisional; Region: PRK08936 373994007725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994007726 NAD(P) binding site [chemical binding]; other site 373994007727 active site 373994007728 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 373994007729 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373994007730 PAS domain S-box; Region: sensory_box; TIGR00229 373994007731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994007732 putative active site [active] 373994007733 heme pocket [chemical binding]; other site 373994007734 PAS fold; Region: PAS_4; pfam08448 373994007735 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994007736 putative active site [active] 373994007737 heme pocket [chemical binding]; other site 373994007738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994007739 PAS fold; Region: PAS_3; pfam08447 373994007740 putative active site [active] 373994007741 heme pocket [chemical binding]; other site 373994007742 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994007743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994007744 putative active site [active] 373994007745 heme pocket [chemical binding]; other site 373994007746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994007747 dimer interface [polypeptide binding]; other site 373994007748 phosphorylation site [posttranslational modification] 373994007749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994007750 ATP binding site [chemical binding]; other site 373994007751 Mg2+ binding site [ion binding]; other site 373994007752 G-X-G motif; other site 373994007753 Response regulator receiver domain; Region: Response_reg; pfam00072 373994007754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994007755 active site 373994007756 phosphorylation site [posttranslational modification] 373994007757 intermolecular recognition site; other site 373994007758 dimerization interface [polypeptide binding]; other site 373994007759 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994007760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994007761 active site 373994007762 phosphorylation site [posttranslational modification] 373994007763 intermolecular recognition site; other site 373994007764 dimerization interface [polypeptide binding]; other site 373994007765 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 373994007766 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 373994007767 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994007768 Ligand Binding Site [chemical binding]; other site 373994007769 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 373994007770 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 373994007771 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 373994007772 dimanganese center [ion binding]; other site 373994007773 putative lipid kinase; Reviewed; Region: PRK00861 373994007774 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 373994007775 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 373994007776 [2Fe-2S] cluster binding site [ion binding]; other site 373994007777 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 373994007778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373994007779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994007780 S-layer homology domain; Region: SLH; pfam00395 373994007781 S-layer homology domain; Region: SLH; pfam00395 373994007782 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994007783 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994007784 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994007785 K-Cl cotransporter; Region: 2a30; TIGR00930 373994007786 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 373994007787 Na binding site [ion binding]; other site 373994007788 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 373994007789 active site 373994007790 SAM binding site [chemical binding]; other site 373994007791 homodimer interface [polypeptide binding]; other site 373994007792 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 373994007793 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 373994007794 putative active site [active] 373994007795 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 373994007796 putative active site [active] 373994007797 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 373994007798 Protein kinase domain; Region: Pkinase; pfam00069 373994007799 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994007800 active site 373994007801 ATP binding site [chemical binding]; other site 373994007802 substrate binding site [chemical binding]; other site 373994007803 activation loop (A-loop); other site 373994007804 GUN4-like; Region: GUN4; pfam05419 373994007805 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994007806 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994007807 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994007808 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994007809 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994007810 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994007811 arogenate dehydrogenase; Reviewed; Region: PRK07417 373994007812 prephenate dehydrogenase; Validated; Region: PRK08507 373994007813 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994007814 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007815 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007816 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007817 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007818 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007819 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007820 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007821 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 373994007822 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 373994007823 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 373994007824 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 373994007825 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 373994007826 16S/18S rRNA binding site [nucleotide binding]; other site 373994007827 S13e-L30e interaction site [polypeptide binding]; other site 373994007828 25S rRNA binding site [nucleotide binding]; other site 373994007829 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 373994007830 active site clefts [active] 373994007831 zinc binding site [ion binding]; other site 373994007832 dimer interface [polypeptide binding]; other site 373994007833 Uncharacterized conserved protein [Function unknown]; Region: COG4278 373994007834 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 373994007835 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 373994007836 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 373994007837 active site 373994007838 HIGH motif; other site 373994007839 dimer interface [polypeptide binding]; other site 373994007840 KMSKS motif; other site 373994007841 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 373994007842 FAD binding site [chemical binding]; other site 373994007843 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 373994007844 Caspase domain; Region: Peptidase_C14; pfam00656 373994007845 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 373994007846 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 373994007847 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373994007848 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 373994007849 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373994007850 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 373994007851 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 373994007852 Hexamer interface [polypeptide binding]; other site 373994007853 Hexagonal pore residue; other site 373994007854 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 373994007855 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 373994007856 Hexamer interface [polypeptide binding]; other site 373994007857 Hexagonal pore residue; other site 373994007858 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 373994007859 Hexamer/Pentamer interface [polypeptide binding]; other site 373994007860 central pore; other site 373994007861 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 373994007862 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 373994007863 trimer interface [polypeptide binding]; other site 373994007864 active site 373994007865 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 373994007866 putative multimerization interface [polypeptide binding]; other site 373994007867 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 373994007868 putative multimerization interface [polypeptide binding]; other site 373994007869 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 373994007870 putative multimerization interface [polypeptide binding]; other site 373994007871 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 373994007872 putative trimer interface [polypeptide binding]; other site 373994007873 putative CoA binding site [chemical binding]; other site 373994007874 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 373994007875 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 373994007876 Hexamer interface [polypeptide binding]; other site 373994007877 Hexagonal pore residue; other site 373994007878 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 373994007879 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 373994007880 Hexamer interface [polypeptide binding]; other site 373994007881 Hexagonal pore residue; other site 373994007882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373994007883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994007884 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 373994007885 putative dimerization interface [polypeptide binding]; other site 373994007886 Family description; Region: VCBS; pfam13517 373994007887 Family description; Region: VCBS; pfam13517 373994007888 FOG: WD40-like repeat [Function unknown]; Region: COG1520 373994007889 conserved hypothetical protein; Region: TIGR02231 373994007890 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 373994007891 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 373994007892 Leucine rich repeat variant; Region: LRV; pfam01816 373994007893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 373994007894 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 373994007895 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 373994007896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994007897 MoxR-like ATPases [General function prediction only]; Region: COG0714 373994007898 Walker A motif; other site 373994007899 ATP binding site [chemical binding]; other site 373994007900 Walker B motif; other site 373994007901 arginine finger; other site 373994007902 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 373994007903 Ycf46; Provisional; Region: ycf46; CHL00195 373994007904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994007905 Walker A motif; other site 373994007906 ATP binding site [chemical binding]; other site 373994007907 Walker B motif; other site 373994007908 arginine finger; other site 373994007909 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994007910 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994007911 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994007912 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994007913 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994007914 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994007915 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994007916 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994007917 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994007918 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994007919 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994007920 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994007921 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994007922 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994007923 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994007924 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994007925 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994007926 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994007927 GAF domain; Region: GAF; pfam01590 373994007928 GAF domain; Region: GAF_2; pfam13185 373994007929 PAS fold; Region: PAS_7; pfam12860 373994007930 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373994007931 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373994007932 metal binding site [ion binding]; metal-binding site 373994007933 active site 373994007934 I-site; other site 373994007935 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373994007936 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 373994007937 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 373994007938 active site 373994007939 catalytic residues [active] 373994007940 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 373994007941 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 373994007942 ligand binding site; other site 373994007943 oligomer interface; other site 373994007944 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 373994007945 dimer interface [polypeptide binding]; other site 373994007946 N-terminal domain interface [polypeptide binding]; other site 373994007947 sulfate 1 binding site; other site 373994007948 chaperone protein DnaJ; Provisional; Region: PRK14299 373994007949 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373994007950 HSP70 interaction site [polypeptide binding]; other site 373994007951 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 373994007952 substrate binding site [polypeptide binding]; other site 373994007953 dimer interface [polypeptide binding]; other site 373994007954 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 373994007955 putative catalytic residues [active] 373994007956 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 373994007957 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 373994007958 dimer interface [polypeptide binding]; other site 373994007959 decamer (pentamer of dimers) interface [polypeptide binding]; other site 373994007960 catalytic triad [active] 373994007961 peroxidatic and resolving cysteines [active] 373994007962 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 373994007963 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 373994007964 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 373994007965 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 373994007966 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 373994007967 Peptidase family M23; Region: Peptidase_M23; pfam01551 373994007968 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 373994007969 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 373994007970 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 373994007971 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994007972 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994007973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994007974 dimer interface [polypeptide binding]; other site 373994007975 phosphorylation site [posttranslational modification] 373994007976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994007977 ATP binding site [chemical binding]; other site 373994007978 Mg2+ binding site [ion binding]; other site 373994007979 G-X-G motif; other site 373994007980 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007981 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994007982 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007983 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007984 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994007985 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007986 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994007987 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007988 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007989 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007990 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994007991 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007992 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007993 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007994 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994007995 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007996 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007997 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007998 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994007999 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994008000 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 373994008001 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 373994008002 putative catalytic cysteine [active] 373994008003 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 373994008004 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 373994008005 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 373994008006 putative NAD(P) binding site [chemical binding]; other site 373994008007 putative substrate binding site [chemical binding]; other site 373994008008 catalytic Zn binding site [ion binding]; other site 373994008009 structural Zn binding site [ion binding]; other site 373994008010 dimer interface [polypeptide binding]; other site 373994008011 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 373994008012 Part of AAA domain; Region: AAA_19; pfam13245 373994008013 Family description; Region: UvrD_C_2; pfam13538 373994008014 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 373994008015 HAMP domain; Region: HAMP; pfam00672 373994008016 dimerization interface [polypeptide binding]; other site 373994008017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994008018 dimer interface [polypeptide binding]; other site 373994008019 phosphorylation site [posttranslational modification] 373994008020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994008021 ATP binding site [chemical binding]; other site 373994008022 Mg2+ binding site [ion binding]; other site 373994008023 G-X-G motif; other site 373994008024 S-adenosylmethionine synthetase; Validated; Region: PRK05250 373994008025 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 373994008026 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 373994008027 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 373994008028 phosphoribulokinase; Provisional; Region: PRK07429 373994008029 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 373994008030 active site 373994008031 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 373994008032 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 373994008033 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 373994008034 dimerization interface [polypeptide binding]; other site 373994008035 FAD binding pocket [chemical binding]; other site 373994008036 FAD binding motif [chemical binding]; other site 373994008037 catalytic residues [active] 373994008038 NAD binding pocket [chemical binding]; other site 373994008039 phosphate binding motif [ion binding]; other site 373994008040 beta-alpha-beta structure motif; other site 373994008041 homoserine dehydrogenase; Provisional; Region: PRK06349 373994008042 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 373994008043 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 373994008044 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 373994008045 S-layer homology domain; Region: SLH; pfam00395 373994008046 S-layer homology domain; Region: SLH; pfam00395 373994008047 S-layer homology domain; Region: SLH; pfam00395 373994008048 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 373994008049 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 373994008050 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 373994008051 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994008052 CHAT domain; Region: CHAT; cl17868 373994008053 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994008054 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994008055 structural tetrad; other site 373994008056 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994008057 structural tetrad; other site 373994008058 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994008059 WD40 repeats; Region: WD40; smart00320 373994008060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994008061 binding surface 373994008062 TPR repeat; Region: TPR_11; pfam13414 373994008063 TPR motif; other site 373994008064 TPR repeat; Region: TPR_11; pfam13414 373994008065 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994008066 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 373994008067 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994008068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994008069 binding surface 373994008070 TPR motif; other site 373994008071 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 373994008072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994008073 TPR motif; other site 373994008074 binding surface 373994008075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994008076 binding surface 373994008077 TPR motif; other site 373994008078 Circadian oscillating protein COP23; Region: COP23; pfam14218 373994008079 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994008080 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 373994008081 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 373994008082 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 373994008083 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 373994008084 acyl-activating enzyme (AAE) consensus motif; other site 373994008085 putative AMP binding site [chemical binding]; other site 373994008086 putative active site [active] 373994008087 putative CoA binding site [chemical binding]; other site 373994008088 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 373994008089 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 373994008090 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 373994008091 E3 interaction surface; other site 373994008092 lipoyl attachment site [posttranslational modification]; other site 373994008093 e3 binding domain; Region: E3_binding; pfam02817 373994008094 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 373994008095 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 373994008096 active site 373994008097 nucleophile elbow; other site 373994008098 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 373994008099 substrate binding site [chemical binding]; other site 373994008100 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 373994008101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994008102 Coenzyme A binding pocket [chemical binding]; other site 373994008103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 373994008104 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 373994008105 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 373994008106 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 373994008107 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 373994008108 C-terminal domain interface [polypeptide binding]; other site 373994008109 GSH binding site (G-site) [chemical binding]; other site 373994008110 dimer interface [polypeptide binding]; other site 373994008111 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 373994008112 N-terminal domain interface [polypeptide binding]; other site 373994008113 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994008114 putative active site [active] 373994008115 spermidine synthase; Provisional; Region: PRK03612 373994008116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994008117 S-adenosylmethionine binding site [chemical binding]; other site 373994008118 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994008119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994008120 S-adenosylmethionine binding site [chemical binding]; other site 373994008121 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 373994008122 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 373994008123 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 373994008124 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373994008125 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994008126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994008127 S-adenosylmethionine binding site [chemical binding]; other site 373994008128 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 373994008129 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 373994008130 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 373994008131 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 373994008132 protein-splicing catalytic site; other site 373994008133 thioester formation/cholesterol transfer; other site 373994008134 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 373994008135 protein-splicing catalytic site; other site 373994008136 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 373994008137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994008138 S-adenosylmethionine binding site [chemical binding]; other site 373994008139 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 373994008140 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 373994008141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994008142 motif II; other site 373994008143 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994008144 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994008145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994008146 S-adenosylmethionine binding site [chemical binding]; other site 373994008147 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994008148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994008149 S-adenosylmethionine binding site [chemical binding]; other site 373994008150 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 373994008151 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 373994008152 DNA binding residues [nucleotide binding] 373994008153 drug binding residues [chemical binding]; other site 373994008154 dimer interface [polypeptide binding]; other site 373994008155 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 373994008156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994008157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994008158 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 373994008159 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 373994008160 TPP-binding site [chemical binding]; other site 373994008161 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 373994008162 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 373994008163 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 373994008164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 373994008165 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 373994008166 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 373994008167 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 373994008168 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 373994008169 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373994008170 catalytic residue [active] 373994008171 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994008172 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 373994008173 Survival protein SurE; Region: SurE; pfam01975 373994008174 Survival protein SurE; Region: SurE; pfam01975 373994008175 Phytase; Region: Phytase; cl17685 373994008176 PhoD-like phosphatase; Region: PhoD; pfam09423 373994008177 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 373994008178 putative active site [active] 373994008179 putative metal binding site [ion binding]; other site 373994008180 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994008181 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 373994008182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373994008183 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 373994008184 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994008185 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 373994008186 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 373994008187 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994008188 WD domain, G-beta repeat; Region: WD40; pfam00400 373994008189 PQQ-like domain; Region: PQQ_2; pfam13360 373994008190 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994008191 structural tetrad; other site 373994008192 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994008193 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994008194 structural tetrad; other site 373994008195 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994008196 putative active site [active] 373994008197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 373994008198 Homeodomain-like domain; Region: HTH_23; pfam13384 373994008199 Winged helix-turn helix; Region: HTH_33; pfam13592 373994008200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994008201 dimer interface [polypeptide binding]; other site 373994008202 phosphorylation site [posttranslational modification] 373994008203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994008204 ATP binding site [chemical binding]; other site 373994008205 Mg2+ binding site [ion binding]; other site 373994008206 G-X-G motif; other site 373994008207 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994008208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994008209 active site 373994008210 phosphorylation site [posttranslational modification] 373994008211 intermolecular recognition site; other site 373994008212 dimerization interface [polypeptide binding]; other site 373994008213 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994008214 DNA binding site [nucleotide binding] 373994008215 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 373994008216 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 373994008217 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 373994008218 HicB family; Region: HicB; pfam05534 373994008219 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994008220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994008221 active site 373994008222 phosphorylation site [posttranslational modification] 373994008223 intermolecular recognition site; other site 373994008224 dimerization interface [polypeptide binding]; other site 373994008225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994008226 DNA binding residues [nucleotide binding] 373994008227 dimerization interface [polypeptide binding]; other site 373994008228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 373994008229 Histidine kinase; Region: HisKA_3; pfam07730 373994008230 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 373994008231 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 373994008232 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 373994008233 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 373994008234 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994008235 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994008236 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 373994008237 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 373994008238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994008239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994008240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994008241 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994008242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994008243 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 373994008244 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 373994008245 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 373994008246 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 373994008247 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 373994008248 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 373994008249 beta-phosphoglucomutase; Region: bPGM; TIGR01990 373994008250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994008251 serine O-acetyltransferase; Region: cysE; TIGR01172 373994008252 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 373994008253 trimer interface [polypeptide binding]; other site 373994008254 active site 373994008255 substrate binding site [chemical binding]; other site 373994008256 CoA binding site [chemical binding]; other site 373994008257 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 373994008258 tocopherol O-methyltransferase; Region: PLN02244 373994008259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994008260 S-adenosylmethionine binding site [chemical binding]; other site 373994008261 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 373994008262 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 373994008263 phosphate binding site [ion binding]; other site 373994008264 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 373994008265 MPT binding site; other site 373994008266 trimer interface [polypeptide binding]; other site 373994008267 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994008268 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994008269 ligand binding site [chemical binding]; other site 373994008270 flexible hinge region; other site 373994008271 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 373994008272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373994008273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994008274 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 373994008275 active site 373994008276 DNA polymerase IV; Validated; Region: PRK02406 373994008277 DNA binding site [nucleotide binding] 373994008278 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 373994008279 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 373994008280 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994008281 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 373994008282 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994008283 active site 373994008284 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994008285 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373994008286 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373994008287 active site 373994008288 catalytic tetrad [active] 373994008289 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 373994008290 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 373994008291 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 373994008292 active site 373994008293 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994008294 CHAT domain; Region: CHAT; cl17868 373994008295 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994008296 CHASE2 domain; Region: CHASE2; pfam05226 373994008297 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373994008298 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 373994008299 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994008300 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994008301 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994008302 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994008303 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994008304 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994008305 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994008306 putative active site [active] 373994008307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994008308 binding surface 373994008309 TPR motif; other site 373994008310 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994008311 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994008312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 373994008313 flavodoxin FldA; Validated; Region: PRK09267 373994008314 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994008315 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 373994008316 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 373994008317 active site 373994008318 TDP-binding site; other site 373994008319 acceptor substrate-binding pocket; other site 373994008320 homodimer interface [polypeptide binding]; other site 373994008321 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 373994008322 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 373994008323 metal-binding site [ion binding] 373994008324 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373994008325 Soluble P-type ATPase [General function prediction only]; Region: COG4087 373994008326 Uncharacterized conserved protein [Function unknown]; Region: COG1262 373994008327 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 373994008328 Uncharacterized conserved protein [Function unknown]; Region: COG1262 373994008329 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 373994008330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994008331 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 373994008332 Walker A motif; other site 373994008333 ATP binding site [chemical binding]; other site 373994008334 Walker B motif; other site 373994008335 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994008336 Cytochrome P450; Region: p450; cl12078 373994008337 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994008338 amidase; Provisional; Region: PRK08137 373994008339 Amidase; Region: Amidase; pfam01425 373994008340 HEAT repeats; Region: HEAT_2; pfam13646 373994008341 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 373994008342 HEAT repeats; Region: HEAT_2; pfam13646 373994008343 protein binding surface [polypeptide binding]; other site 373994008344 Caspase domain; Region: Peptidase_C14; pfam00656 373994008345 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 373994008346 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 373994008347 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994008348 Cytochrome P450; Region: p450; pfam00067 373994008349 Transcriptional regulator [Transcription]; Region: LytR; COG1316 373994008350 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 373994008351 hypothetical protein; Provisional; Region: PRK06753 373994008352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994008353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994008354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994008355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994008356 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 373994008357 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 373994008358 ATP-grasp domain; Region: ATP-grasp_4; cl17255 373994008359 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 373994008360 Amidase; Region: Amidase; pfam01425 373994008361 CAAX protease self-immunity; Region: Abi; pfam02517 373994008362 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994008363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994008364 S-adenosylmethionine binding site [chemical binding]; other site 373994008365 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 373994008366 PIN domain; Region: PIN_3; pfam13470 373994008367 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 373994008368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994008369 Coenzyme A binding pocket [chemical binding]; other site 373994008370 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 373994008371 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373994008372 ABC-ATPase subunit interface; other site 373994008373 dimer interface [polypeptide binding]; other site 373994008374 putative PBP binding regions; other site 373994008375 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 373994008376 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 373994008377 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 373994008378 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 373994008379 metal binding site [ion binding]; metal-binding site 373994008380 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 373994008381 Sporulation and spore germination; Region: Germane; pfam10646 373994008382 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 373994008383 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 373994008384 putative dimer interface [polypeptide binding]; other site 373994008385 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994008386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994008387 active site 373994008388 phosphorylation site [posttranslational modification] 373994008389 intermolecular recognition site; other site 373994008390 dimerization interface [polypeptide binding]; other site 373994008391 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994008392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994008393 active site 373994008394 phosphorylation site [posttranslational modification] 373994008395 intermolecular recognition site; other site 373994008396 dimerization interface [polypeptide binding]; other site 373994008397 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994008398 DNA binding site [nucleotide binding] 373994008399 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373994008400 putative binding surface; other site 373994008401 active site 373994008402 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994008403 Response regulator receiver domain; Region: Response_reg; pfam00072 373994008404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994008405 active site 373994008406 phosphorylation site [posttranslational modification] 373994008407 intermolecular recognition site; other site 373994008408 dimerization interface [polypeptide binding]; other site 373994008409 PAS domain S-box; Region: sensory_box; TIGR00229 373994008410 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994008411 putative active site [active] 373994008412 heme pocket [chemical binding]; other site 373994008413 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994008414 GAF domain; Region: GAF; pfam01590 373994008415 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 373994008416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994008417 putative active site [active] 373994008418 heme pocket [chemical binding]; other site 373994008419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994008420 dimer interface [polypeptide binding]; other site 373994008421 phosphorylation site [posttranslational modification] 373994008422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994008423 ATP binding site [chemical binding]; other site 373994008424 Mg2+ binding site [ion binding]; other site 373994008425 G-X-G motif; other site 373994008426 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994008427 Ligand Binding Site [chemical binding]; other site 373994008428 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994008429 Ligand Binding Site [chemical binding]; other site 373994008430 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 373994008431 FMN binding site [chemical binding]; other site 373994008432 dimer interface [polypeptide binding]; other site 373994008433 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 373994008434 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373994008435 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 373994008436 active site residue [active] 373994008437 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 373994008438 FOG: CBS domain [General function prediction only]; Region: COG0517 373994008439 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 373994008440 FOG: CBS domain [General function prediction only]; Region: COG0517 373994008441 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 373994008442 PAS domain S-box; Region: sensory_box; TIGR00229 373994008443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994008444 putative active site [active] 373994008445 heme pocket [chemical binding]; other site 373994008446 PAS domain S-box; Region: sensory_box; TIGR00229 373994008447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994008448 putative active site [active] 373994008449 heme pocket [chemical binding]; other site 373994008450 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 373994008451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994008452 putative active site [active] 373994008453 heme pocket [chemical binding]; other site 373994008454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994008455 dimer interface [polypeptide binding]; other site 373994008456 phosphorylation site [posttranslational modification] 373994008457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994008458 ATP binding site [chemical binding]; other site 373994008459 Mg2+ binding site [ion binding]; other site 373994008460 G-X-G motif; other site 373994008461 Response regulator receiver domain; Region: Response_reg; pfam00072 373994008462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994008463 active site 373994008464 phosphorylation site [posttranslational modification] 373994008465 intermolecular recognition site; other site 373994008466 dimerization interface [polypeptide binding]; other site 373994008467 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994008468 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 373994008469 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994008470 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994008471 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 373994008472 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994008473 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373994008474 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 373994008475 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994008476 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 373994008477 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 373994008478 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994008479 FtsX-like permease family; Region: FtsX; pfam02687 373994008480 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994008481 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 373994008482 FtsX-like permease family; Region: FtsX; pfam02687 373994008483 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 373994008484 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 373994008485 Walker A/P-loop; other site 373994008486 ATP binding site [chemical binding]; other site 373994008487 Q-loop/lid; other site 373994008488 ABC transporter signature motif; other site 373994008489 Walker B; other site 373994008490 D-loop; other site 373994008491 H-loop/switch region; other site 373994008492 Predicted membrane protein [Function unknown]; Region: COG3174 373994008493 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 373994008494 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 373994008495 FOG: CBS domain [General function prediction only]; Region: COG0517 373994008496 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 373994008497 CP12 domain; Region: CP12; pfam02672 373994008498 pyruvate kinase; Validated; Region: PRK08187 373994008499 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 373994008500 domain interfaces; other site 373994008501 active site 373994008502 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 373994008503 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 373994008504 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994008505 Ligand Binding Site [chemical binding]; other site 373994008506 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 373994008507 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 373994008508 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373994008509 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 373994008510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994008511 motif II; other site 373994008512 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 373994008513 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994008514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994008515 active site 373994008516 phosphorylation site [posttranslational modification] 373994008517 intermolecular recognition site; other site 373994008518 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 373994008519 DNA binding residues [nucleotide binding] 373994008520 CHASE2 domain; Region: CHASE2; pfam05226 373994008521 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994008522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 373994008523 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994008524 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994008525 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994008526 TPR repeat; Region: TPR_11; pfam13414 373994008527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 373994008528 binding surface 373994008529 TPR motif; other site 373994008530 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994008531 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994008532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994008533 binding surface 373994008534 TPR motif; other site 373994008535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 373994008536 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994008537 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994008538 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994008539 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994008540 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994008541 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994008542 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994008543 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994008544 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 373994008545 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 373994008546 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 373994008547 Surface antigen; Region: Bac_surface_Ag; pfam01103 373994008548 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994008549 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994008550 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994008551 Response regulator receiver domain; Region: Response_reg; pfam00072 373994008552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994008553 active site 373994008554 phosphorylation site [posttranslational modification] 373994008555 intermolecular recognition site; other site 373994008556 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994008557 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994008558 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994008559 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994008560 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 373994008561 active sites [active] 373994008562 tetramer interface [polypeptide binding]; other site 373994008563 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 373994008564 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 373994008565 acyl-activating enzyme (AAE) consensus motif; other site 373994008566 putative AMP binding site [chemical binding]; other site 373994008567 putative active site [active] 373994008568 putative CoA binding site [chemical binding]; other site 373994008569 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 373994008570 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 373994008571 PYR/PP interface [polypeptide binding]; other site 373994008572 dimer interface [polypeptide binding]; other site 373994008573 TPP binding site [chemical binding]; other site 373994008574 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 373994008575 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 373994008576 TPP-binding site [chemical binding]; other site 373994008577 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 373994008578 active site 373994008579 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 373994008580 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 373994008581 prephenate dehydrogenase; Provisional; Region: PRK06444 373994008582 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 373994008583 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994008584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994008585 Walker A/P-loop; other site 373994008586 ATP binding site [chemical binding]; other site 373994008587 Q-loop/lid; other site 373994008588 ABC transporter signature motif; other site 373994008589 Walker B; other site 373994008590 D-loop; other site 373994008591 H-loop/switch region; other site 373994008592 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 373994008593 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994008594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994008595 Walker A/P-loop; other site 373994008596 ATP binding site [chemical binding]; other site 373994008597 Q-loop/lid; other site 373994008598 ABC transporter signature motif; other site 373994008599 Walker B; other site 373994008600 D-loop; other site 373994008601 H-loop/switch region; other site 373994008602 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 373994008603 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 373994008604 Walker A/P-loop; other site 373994008605 ATP binding site [chemical binding]; other site 373994008606 Q-loop/lid; other site 373994008607 ABC transporter signature motif; other site 373994008608 Walker B; other site 373994008609 D-loop; other site 373994008610 H-loop/switch region; other site 373994008611 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994008612 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 373994008613 FtsX-like permease family; Region: FtsX; pfam02687 373994008614 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994008615 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994008616 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994008617 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 373994008618 trehalose synthase; Region: treS_nterm; TIGR02456 373994008619 active site 373994008620 catalytic site [active] 373994008621 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 373994008622 Heme NO binding associated; Region: HNOBA; pfam07701 373994008623 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 373994008624 cyclase homology domain; Region: CHD; cd07302 373994008625 nucleotidyl binding site; other site 373994008626 metal binding site [ion binding]; metal-binding site 373994008627 dimer interface [polypeptide binding]; other site 373994008628 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 373994008629 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994008630 non-specific DNA binding site [nucleotide binding]; other site 373994008631 salt bridge; other site 373994008632 sequence-specific DNA binding site [nucleotide binding]; other site 373994008633 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 373994008634 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 373994008635 active site 373994008636 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 373994008637 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 373994008638 cofactor binding site; other site 373994008639 DNA binding site [nucleotide binding] 373994008640 substrate interaction site [chemical binding]; other site 373994008641 large tegument protein UL36; Provisional; Region: PHA03247 373994008642 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 373994008643 S-layer homology domain; Region: SLH; pfam00395 373994008644 S-layer homology domain; Region: SLH; pfam00395 373994008645 S-layer homology domain; Region: SLH; pfam00395 373994008646 Ion transport protein; Region: Ion_trans; pfam00520 373994008647 Ion channel; Region: Ion_trans_2; pfam07885 373994008648 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 373994008649 Double zinc ribbon; Region: DZR; pfam12773 373994008650 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994008651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994008652 active site 373994008653 phosphorylation site [posttranslational modification] 373994008654 intermolecular recognition site; other site 373994008655 dimerization interface [polypeptide binding]; other site 373994008656 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994008657 DNA binding residues [nucleotide binding] 373994008658 dimerization interface [polypeptide binding]; other site 373994008659 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 373994008660 Histidine kinase; Region: HisKA_3; pfam07730 373994008661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994008662 ATP binding site [chemical binding]; other site 373994008663 Mg2+ binding site [ion binding]; other site 373994008664 G-X-G motif; other site 373994008665 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 373994008666 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 373994008667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 373994008668 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 373994008669 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 373994008670 putative active site [active] 373994008671 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 373994008672 putative active site [active] 373994008673 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 373994008674 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 373994008675 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 373994008676 catalytic triad [active] 373994008677 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 373994008678 Repair protein; Region: Repair_PSII; pfam04536 373994008679 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 373994008680 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 373994008681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 373994008682 Protein of unknown function, DUF482; Region: DUF482; pfam04339 373994008683 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 373994008684 RibD C-terminal domain; Region: RibD_C; cl17279 373994008685 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994008686 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994008687 dimerization interface [polypeptide binding]; other site 373994008688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994008689 dimer interface [polypeptide binding]; other site 373994008690 phosphorylation site [posttranslational modification] 373994008691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994008692 ATP binding site [chemical binding]; other site 373994008693 Mg2+ binding site [ion binding]; other site 373994008694 G-X-G motif; other site 373994008695 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 373994008696 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 373994008697 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 373994008698 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 373994008699 dimerization interface [polypeptide binding]; other site 373994008700 active site 373994008701 metal binding site [ion binding]; metal-binding site 373994008702 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 373994008703 dsRNA binding site [nucleotide binding]; other site 373994008704 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 373994008705 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 373994008706 oligomer interface [polypeptide binding]; other site 373994008707 metal binding site [ion binding]; metal-binding site 373994008708 metal binding site [ion binding]; metal-binding site 373994008709 Cl binding site [ion binding]; other site 373994008710 aspartate ring; other site 373994008711 basic sphincter; other site 373994008712 putative hydrophobic gate; other site 373994008713 periplasmic entrance; other site 373994008714 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 373994008715 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 373994008716 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 373994008717 Surface antigen; Region: Bac_surface_Ag; pfam01103 373994008718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 373994008719 Histidine kinase; Region: HisKA_3; pfam07730 373994008720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994008721 ATP binding site [chemical binding]; other site 373994008722 Mg2+ binding site [ion binding]; other site 373994008723 G-X-G motif; other site 373994008724 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994008725 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994008726 DNA binding residues [nucleotide binding] 373994008727 dimerization interface [polypeptide binding]; other site 373994008728 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 373994008729 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 373994008730 active site residue [active] 373994008731 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 373994008732 active site residue [active] 373994008733 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994008734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994008735 active site 373994008736 phosphorylation site [posttranslational modification] 373994008737 intermolecular recognition site; other site 373994008738 dimerization interface [polypeptide binding]; other site 373994008739 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994008740 DNA binding residues [nucleotide binding] 373994008741 dimerization interface [polypeptide binding]; other site 373994008742 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 373994008743 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 373994008744 ring oligomerisation interface [polypeptide binding]; other site 373994008745 ATP/Mg binding site [chemical binding]; other site 373994008746 stacking interactions; other site 373994008747 hinge regions; other site 373994008748 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 373994008749 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 373994008750 Mg++ binding site [ion binding]; other site 373994008751 putative catalytic motif [active] 373994008752 substrate binding site [chemical binding]; other site 373994008753 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 373994008754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 373994008755 Uncharacterized conserved protein [Function unknown]; Region: COG1432 373994008756 LabA_like proteins; Region: LabA; cd10911 373994008757 putative metal binding site [ion binding]; other site 373994008758 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994008759 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994008760 PAS fold; Region: PAS_4; pfam08448 373994008761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994008762 putative active site [active] 373994008763 heme pocket [chemical binding]; other site 373994008764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994008765 putative active site [active] 373994008766 heme pocket [chemical binding]; other site 373994008767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994008768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994008769 dimer interface [polypeptide binding]; other site 373994008770 phosphorylation site [posttranslational modification] 373994008771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994008772 ATP binding site [chemical binding]; other site 373994008773 Mg2+ binding site [ion binding]; other site 373994008774 G-X-G motif; other site 373994008775 Uncharacterized conserved protein [Function unknown]; Region: COG2836 373994008776 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 373994008777 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 373994008778 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 373994008779 NAD binding site [chemical binding]; other site 373994008780 homodimer interface [polypeptide binding]; other site 373994008781 active site 373994008782 substrate binding site [chemical binding]; other site 373994008783 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 373994008784 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994008785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994008786 Walker A/P-loop; other site 373994008787 ATP binding site [chemical binding]; other site 373994008788 Q-loop/lid; other site 373994008789 ABC transporter signature motif; other site 373994008790 Walker B; other site 373994008791 D-loop; other site 373994008792 H-loop/switch region; other site 373994008793 Bacterial sugar transferase; Region: Bac_transf; pfam02397 373994008794 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 373994008795 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 373994008796 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 373994008797 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994008798 GAF domain; Region: GAF; pfam01590 373994008799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994008800 binding surface 373994008801 TPR repeat; Region: TPR_11; pfam13414 373994008802 TPR motif; other site 373994008803 TPR repeat; Region: TPR_11; pfam13414 373994008804 TPR repeat; Region: TPR_11; pfam13414 373994008805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994008806 binding surface 373994008807 TPR motif; other site 373994008808 TPR repeat; Region: TPR_11; pfam13414 373994008809 TPR repeat; Region: TPR_11; pfam13414 373994008810 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 373994008811 Na binding site [ion binding]; other site 373994008812 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 373994008813 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 373994008814 dimer interface [polypeptide binding]; other site 373994008815 catalytic residues [active] 373994008816 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 373994008817 UreF; Region: UreF; pfam01730 373994008818 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 373994008819 G1 box; other site 373994008820 GTP/Mg2+ binding site [chemical binding]; other site 373994008821 G2 box; other site 373994008822 Switch I region; other site 373994008823 G3 box; other site 373994008824 Switch II region; other site 373994008825 G4 box; other site 373994008826 G5 box; other site 373994008827 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 373994008828 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 373994008829 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 373994008830 Protein of unknown function (DUF565); Region: DUF565; pfam04483 373994008831 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 373994008832 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 373994008833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994008834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994008835 dimer interface [polypeptide binding]; other site 373994008836 phosphorylation site [posttranslational modification] 373994008837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994008838 ATP binding site [chemical binding]; other site 373994008839 Mg2+ binding site [ion binding]; other site 373994008840 G-X-G motif; other site 373994008841 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994008842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994008843 active site 373994008844 phosphorylation site [posttranslational modification] 373994008845 intermolecular recognition site; other site 373994008846 dimerization interface [polypeptide binding]; other site 373994008847 KaiA domain; Region: KaiA; pfam07688 373994008848 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 373994008849 tetramer interface [polypeptide binding]; other site 373994008850 dimer interface [polypeptide binding]; other site 373994008851 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 373994008852 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 373994008853 Walker A motif; other site 373994008854 ATP binding site [chemical binding]; other site 373994008855 Walker B motif; other site 373994008856 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 373994008857 ATP binding site [chemical binding]; other site 373994008858 Walker B motif; other site 373994008859 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 373994008860 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 373994008861 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373994008862 RNA binding surface [nucleotide binding]; other site 373994008863 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 373994008864 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 373994008865 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 373994008866 HicB family; Region: HicB; pfam05534 373994008867 DNA-sulfur modification-associated; Region: DndB; pfam14072 373994008868 DGQHR domain; Region: DGQHR; TIGR03187 373994008869 magnesium chelatase subunit H; Provisional; Region: PRK12493 373994008870 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 373994008871 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 373994008872 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 373994008873 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994008874 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994008875 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994008876 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994008877 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 373994008878 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994008879 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994008880 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 373994008881 active site 373994008882 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 373994008883 Peptidase family M23; Region: Peptidase_M23; pfam01551 373994008884 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 373994008885 Peptidase family M23; Region: Peptidase_M23; pfam01551 373994008886 cell division protein; Validated; Region: ftsH; CHL00176 373994008887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994008888 Walker A motif; other site 373994008889 ATP binding site [chemical binding]; other site 373994008890 Walker B motif; other site 373994008891 arginine finger; other site 373994008892 Peptidase family M41; Region: Peptidase_M41; pfam01434 373994008893 Predicted flavoprotein [General function prediction only]; Region: COG0431 373994008894 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 373994008895 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994008896 putative active site [active] 373994008897 proline aminopeptidase P II; Provisional; Region: PRK10879 373994008898 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 373994008899 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 373994008900 active site 373994008901 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 373994008902 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 373994008903 Family description; Region: VCBS; pfam13517 373994008904 Family description; Region: VCBS; pfam13517 373994008905 Family description; Region: VCBS; pfam13517 373994008906 Family description; Region: VCBS; pfam13517 373994008907 Family description; Region: VCBS; pfam13517 373994008908 Family description; Region: VCBS; pfam13517 373994008909 Family description; Region: VCBS; pfam13517 373994008910 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 373994008911 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 373994008912 putative active site [active] 373994008913 putative NTP binding site [chemical binding]; other site 373994008914 putative nucleic acid binding site [nucleotide binding]; other site 373994008915 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994008916 putative active site [active] 373994008917 Protein kinase domain; Region: Pkinase; pfam00069 373994008918 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994008919 active site 373994008920 ATP binding site [chemical binding]; other site 373994008921 substrate binding site [chemical binding]; other site 373994008922 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994008923 substrate binding site [chemical binding]; other site 373994008924 activation loop (A-loop); other site 373994008925 activation loop (A-loop); other site 373994008926 AAA ATPase domain; Region: AAA_16; pfam13191 373994008927 Predicted ATPase [General function prediction only]; Region: COG3899 373994008928 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994008929 GAF domain; Region: GAF; pfam01590 373994008930 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994008931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994008932 dimer interface [polypeptide binding]; other site 373994008933 phosphorylation site [posttranslational modification] 373994008934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994008935 ATP binding site [chemical binding]; other site 373994008936 Mg2+ binding site [ion binding]; other site 373994008937 G-X-G motif; other site 373994008938 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 373994008939 Domain of unknown function DUF20; Region: UPF0118; pfam01594 373994008940 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 373994008941 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 373994008942 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_2; cd13149 373994008943 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 373994008944 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 373994008945 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 373994008946 DNA binding residues [nucleotide binding] 373994008947 dimer interface [polypeptide binding]; other site 373994008948 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 373994008949 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 373994008950 Calx-beta domain; Region: Calx-beta; cl02522 373994008951 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 373994008952 nucleophilic elbow; other site 373994008953 catalytic triad; other site 373994008954 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 373994008955 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 373994008956 P-loop; other site 373994008957 Magnesium ion binding site [ion binding]; other site 373994008958 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 373994008959 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373994008960 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 373994008961 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 373994008962 CP12 domain; Region: CP12; pfam02672 373994008963 Predicted metal-binding protein [General function prediction only]; Region: COG3019 373994008964 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 373994008965 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994008966 dimer interface [polypeptide binding]; other site 373994008967 phosphorylation site [posttranslational modification] 373994008968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994008969 ATP binding site [chemical binding]; other site 373994008970 Mg2+ binding site [ion binding]; other site 373994008971 G-X-G motif; other site 373994008972 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994008973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994008974 active site 373994008975 phosphorylation site [posttranslational modification] 373994008976 intermolecular recognition site; other site 373994008977 dimerization interface [polypeptide binding]; other site 373994008978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994008979 DNA binding site [nucleotide binding] 373994008980 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 373994008981 GSH binding site [chemical binding]; other site 373994008982 catalytic residues [active] 373994008983 Methylamine utilisation protein MauE; Region: MauE; pfam07291 373994008984 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 373994008985 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 373994008986 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 373994008987 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 373994008988 shikimate binding site; other site 373994008989 NAD(P) binding site [chemical binding]; other site 373994008990 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 373994008991 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 373994008992 Sulfate transporter family; Region: Sulfate_transp; pfam00916 373994008993 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 373994008994 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 373994008995 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 373994008996 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 373994008997 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 373994008998 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 373994008999 Ligand Binding Site [chemical binding]; other site 373994009000 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994009001 Ligand Binding Site [chemical binding]; other site 373994009002 Predicted permease [General function prediction only]; Region: COG3329 373994009003 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 373994009004 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 373994009005 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 373994009006 Subunit I/III interface [polypeptide binding]; other site 373994009007 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 373994009008 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 373994009009 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 373994009010 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 373994009011 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 373994009012 Predicted membrane protein [Function unknown]; Region: COG4244 373994009013 Predicted membrane protein [Function unknown]; Region: COG4244 373994009014 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 373994009015 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373994009016 active site 373994009017 metal binding site [ion binding]; metal-binding site 373994009018 MarC family integral membrane protein; Region: MarC; pfam01914 373994009019 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 373994009020 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 373994009021 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 373994009022 Subunit I/III interface [polypeptide binding]; other site 373994009023 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 373994009024 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 373994009025 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 373994009026 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 373994009027 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 373994009028 Predicted membrane protein [Function unknown]; Region: COG4244 373994009029 Predicted membrane protein [Function unknown]; Region: COG4244 373994009030 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 373994009031 putative rRNA binding site [nucleotide binding]; other site 373994009032 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 373994009033 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 373994009034 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 373994009035 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 373994009036 active site 373994009037 catalytic residues [active] 373994009038 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 373994009039 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 373994009040 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 373994009041 heterotetramer interface [polypeptide binding]; other site 373994009042 active site pocket [active] 373994009043 cleavage site 373994009044 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 373994009045 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 373994009046 GatB domain; Region: GatB_Yqey; pfam02637 373994009047 Predicted membrane protein [Function unknown]; Region: COG2323 373994009048 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 373994009049 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 373994009050 nucleotide binding pocket [chemical binding]; other site 373994009051 K-X-D-G motif; other site 373994009052 catalytic site [active] 373994009053 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 373994009054 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 373994009055 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 373994009056 Dimer interface [polypeptide binding]; other site 373994009057 BRCT sequence motif; other site 373994009058 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 373994009059 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 373994009060 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 373994009061 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 373994009062 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 373994009063 putative NAD(P) binding site [chemical binding]; other site 373994009064 catalytic Zn binding site [ion binding]; other site 373994009065 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009066 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994009067 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009068 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994009069 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009070 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009071 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009072 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009073 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009074 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 373994009075 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994009076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994009077 S-adenosylmethionine binding site [chemical binding]; other site 373994009078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 373994009079 glutamine synthetase, type I; Region: GlnA; TIGR00653 373994009080 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 373994009081 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 373994009082 allophycocyanin, beta subunit; Region: apcB; TIGR01337 373994009083 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 373994009084 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373994009085 RNA binding surface [nucleotide binding]; other site 373994009086 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 373994009087 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 373994009088 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 373994009089 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 373994009090 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 373994009091 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 373994009092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994009093 NAD(P) binding site [chemical binding]; other site 373994009094 active site 373994009095 DNA gyrase subunit A; Validated; Region: PRK05560 373994009096 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 373994009097 CAP-like domain; other site 373994009098 active site 373994009099 primary dimer interface [polypeptide binding]; other site 373994009100 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373994009101 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373994009102 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373994009103 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373994009104 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373994009105 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373994009106 PAS domain; Region: PAS_9; pfam13426 373994009107 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373994009108 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373994009109 metal binding site [ion binding]; metal-binding site 373994009110 active site 373994009111 I-site; other site 373994009112 putative fimbrial chaperone protein; Provisional; Region: PRK09918 373994009113 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 373994009114 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373994009115 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 373994009116 HSP70 interaction site [polypeptide binding]; other site 373994009117 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373994009118 Clp protease; Region: CLP_protease; pfam00574 373994009119 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 373994009120 oligomer interface [polypeptide binding]; other site 373994009121 active site residues [active] 373994009122 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 373994009123 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 373994009124 oligomer interface [polypeptide binding]; other site 373994009125 active site residues [active] 373994009126 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 373994009127 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 373994009128 metal ion-dependent adhesion site (MIDAS); other site 373994009129 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 373994009130 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373994009131 putative metal binding site [ion binding]; other site 373994009132 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 373994009133 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 373994009134 active site 373994009135 substrate binding site [chemical binding]; other site 373994009136 Mg2+ binding site [ion binding]; other site 373994009137 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 373994009138 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 373994009139 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 373994009140 putative active site [active] 373994009141 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 373994009142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994009143 FeS/SAM binding site; other site 373994009144 HemN C-terminal domain; Region: HemN_C; pfam06969 373994009145 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 373994009146 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994009147 Ligand Binding Site [chemical binding]; other site 373994009148 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 373994009149 Phosphoglycerate kinase; Region: PGK; pfam00162 373994009150 substrate binding site [chemical binding]; other site 373994009151 hinge regions; other site 373994009152 ADP binding site [chemical binding]; other site 373994009153 catalytic site [active] 373994009154 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 373994009155 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 373994009156 nudix motif; other site 373994009157 Right handed beta helix region; Region: Beta_helix; pfam13229 373994009158 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 373994009159 Double zinc ribbon; Region: DZR; pfam12773 373994009160 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994009161 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994009162 active site 373994009163 ATP binding site [chemical binding]; other site 373994009164 substrate binding site [chemical binding]; other site 373994009165 activation loop (A-loop); other site 373994009166 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994009167 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994009168 active site 373994009169 ATP binding site [chemical binding]; other site 373994009170 substrate binding site [chemical binding]; other site 373994009171 activation loop (A-loop); other site 373994009172 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 373994009173 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 373994009174 acyl-activating enzyme (AAE) consensus motif; other site 373994009175 active site 373994009176 AMP binding site [chemical binding]; other site 373994009177 CoA binding site [chemical binding]; other site 373994009178 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 373994009179 Fasciclin domain; Region: Fasciclin; pfam02469 373994009180 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 373994009181 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 373994009182 C-terminal domain interface [polypeptide binding]; other site 373994009183 GSH binding site (G-site) [chemical binding]; other site 373994009184 dimer interface [polypeptide binding]; other site 373994009185 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 373994009186 N-terminal domain interface [polypeptide binding]; other site 373994009187 HAS barrel domain; Region: HAS-barrel; pfam09378 373994009188 HerA helicase [Replication, recombination, and repair]; Region: COG0433 373994009189 Domain of unknown function DUF87; Region: DUF87; pfam01935 373994009190 RNA polymerase sigma factor; Validated; Region: PRK05949 373994009191 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 373994009192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373994009193 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373994009194 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373994009195 DNA binding residues [nucleotide binding] 373994009196 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 373994009197 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 373994009198 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 373994009199 homodimer interface [polypeptide binding]; other site 373994009200 Walker A motif; other site 373994009201 ATP binding site [chemical binding]; other site 373994009202 hydroxycobalamin binding site [chemical binding]; other site 373994009203 Walker B motif; other site 373994009204 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994009205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994009206 active site 373994009207 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 373994009208 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 373994009209 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 373994009210 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 373994009211 conserved cys residue [active] 373994009212 MltA specific insert domain; Region: MltA; cl08398 373994009213 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 373994009214 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 373994009215 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 373994009216 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 373994009217 active site 373994009218 catalytic site [active] 373994009219 substrate binding site [chemical binding]; other site 373994009220 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994009221 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994009222 Uncharacterized conserved protein [Function unknown]; Region: COG2128 373994009223 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 373994009224 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 373994009225 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 373994009226 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 373994009227 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 373994009228 glycogen branching enzyme; Provisional; Region: PRK05402 373994009229 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 373994009230 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 373994009231 active site 373994009232 catalytic site [active] 373994009233 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 373994009234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994009235 NACHT domain; Region: NACHT; pfam05729 373994009236 Walker A/P-loop; other site 373994009237 ATP binding site [chemical binding]; other site 373994009238 Q-loop/lid; other site 373994009239 ABC transporter signature motif; other site 373994009240 Walker B; other site 373994009241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009242 TPR motif; other site 373994009243 binding surface 373994009244 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994009245 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994009246 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994009247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009248 binding surface 373994009249 TPR motif; other site 373994009250 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994009251 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994009252 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994009253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009254 binding surface 373994009255 TPR motif; other site 373994009256 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994009257 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994009258 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994009259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009260 binding surface 373994009261 TPR motif; other site 373994009262 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994009263 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994009264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009265 binding surface 373994009266 TPR motif; other site 373994009267 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994009268 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 373994009269 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 373994009270 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 373994009271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373994009272 catalytic residue [active] 373994009273 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 373994009274 RNase_H superfamily; Region: RNase_H_2; pfam13482 373994009275 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 373994009276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 373994009277 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994009278 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994009279 active site 373994009280 ATP binding site [chemical binding]; other site 373994009281 substrate binding site [chemical binding]; other site 373994009282 activation loop (A-loop); other site 373994009283 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 373994009284 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 373994009285 HIGH motif; other site 373994009286 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 373994009287 active site 373994009288 KMSKS motif; other site 373994009289 cell division protein; Validated; Region: ftsH; CHL00176 373994009290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994009291 Walker A motif; other site 373994009292 ATP binding site [chemical binding]; other site 373994009293 Walker B motif; other site 373994009294 arginine finger; other site 373994009295 Peptidase family M41; Region: Peptidase_M41; pfam01434 373994009296 Response regulator receiver domain; Region: Response_reg; pfam00072 373994009297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994009298 active site 373994009299 phosphorylation site [posttranslational modification] 373994009300 intermolecular recognition site; other site 373994009301 dimerization interface [polypeptide binding]; other site 373994009302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 373994009303 dimer interface [polypeptide binding]; other site 373994009304 phosphorylation site [posttranslational modification] 373994009305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994009306 ATP binding site [chemical binding]; other site 373994009307 Mg2+ binding site [ion binding]; other site 373994009308 G-X-G motif; other site 373994009309 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 373994009310 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 373994009311 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373994009312 substrate binding pocket [chemical binding]; other site 373994009313 membrane-bound complex binding site; other site 373994009314 hinge residues; other site 373994009315 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 373994009316 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 373994009317 catalytic core [active] 373994009318 Cupin domain; Region: Cupin_2; cl17218 373994009319 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 373994009320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994009321 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 373994009322 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 373994009323 FMN binding site [chemical binding]; other site 373994009324 active site 373994009325 substrate binding site [chemical binding]; other site 373994009326 catalytic residue [active] 373994009327 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 373994009328 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 373994009329 Walker A/P-loop; other site 373994009330 ATP binding site [chemical binding]; other site 373994009331 Q-loop/lid; other site 373994009332 ABC transporter signature motif; other site 373994009333 Walker B; other site 373994009334 D-loop; other site 373994009335 H-loop/switch region; other site 373994009336 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994009337 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 373994009338 FtsX-like permease family; Region: FtsX; pfam02687 373994009339 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994009340 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 373994009341 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994009342 YHYH protein; Region: YHYH; pfam14240 373994009343 YHYH protein; Region: YHYH; pfam14240 373994009344 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994009345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994009346 active site 373994009347 phosphorylation site [posttranslational modification] 373994009348 intermolecular recognition site; other site 373994009349 dimerization interface [polypeptide binding]; other site 373994009350 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994009351 DNA binding site [nucleotide binding] 373994009352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994009353 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994009354 dimerization interface [polypeptide binding]; other site 373994009355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994009356 dimer interface [polypeptide binding]; other site 373994009357 phosphorylation site [posttranslational modification] 373994009358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994009359 ATP binding site [chemical binding]; other site 373994009360 Mg2+ binding site [ion binding]; other site 373994009361 G-X-G motif; other site 373994009362 Leucine rich repeat; Region: LRR_8; pfam13855 373994009363 Leucine rich repeat; Region: LRR_8; pfam13855 373994009364 Leucine rich repeat; Region: LRR_8; pfam13855 373994009365 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994009366 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994009367 Leucine rich repeat; Region: LRR_8; pfam13855 373994009368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 373994009369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994009370 Coenzyme A binding pocket [chemical binding]; other site 373994009371 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 373994009372 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994009373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994009374 S-adenosylmethionine binding site [chemical binding]; other site 373994009375 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 373994009376 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373994009377 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373994009378 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 373994009379 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 373994009380 Electron transfer DM13; Region: DM13; pfam10517 373994009381 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 373994009382 RibD C-terminal domain; Region: RibD_C; cl17279 373994009383 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 373994009384 classical (c) SDRs; Region: SDR_c; cd05233 373994009385 NAD(P) binding site [chemical binding]; other site 373994009386 active site 373994009387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994009388 PAS domain; Region: PAS_9; pfam13426 373994009389 putative active site [active] 373994009390 heme pocket [chemical binding]; other site 373994009391 PAS fold; Region: PAS_4; pfam08448 373994009392 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994009393 GAF domain; Region: GAF; pfam01590 373994009394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994009395 dimer interface [polypeptide binding]; other site 373994009396 phosphorylation site [posttranslational modification] 373994009397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994009398 ATP binding site [chemical binding]; other site 373994009399 Mg2+ binding site [ion binding]; other site 373994009400 G-X-G motif; other site 373994009401 Response regulator receiver domain; Region: Response_reg; pfam00072 373994009402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994009403 active site 373994009404 phosphorylation site [posttranslational modification] 373994009405 intermolecular recognition site; other site 373994009406 dimerization interface [polypeptide binding]; other site 373994009407 Response regulator receiver domain; Region: Response_reg; pfam00072 373994009408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994009409 active site 373994009410 phosphorylation site [posttranslational modification] 373994009411 intermolecular recognition site; other site 373994009412 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994009413 dimer interface [polypeptide binding]; other site 373994009414 phosphorylation site [posttranslational modification] 373994009415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994009416 ATP binding site [chemical binding]; other site 373994009417 Mg2+ binding site [ion binding]; other site 373994009418 G-X-G motif; other site 373994009419 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994009420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994009421 active site 373994009422 phosphorylation site [posttranslational modification] 373994009423 intermolecular recognition site; other site 373994009424 dimerization interface [polypeptide binding]; other site 373994009425 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 373994009426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994009427 putative active site [active] 373994009428 heme pocket [chemical binding]; other site 373994009429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994009430 dimer interface [polypeptide binding]; other site 373994009431 phosphorylation site [posttranslational modification] 373994009432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994009433 ATP binding site [chemical binding]; other site 373994009434 Mg2+ binding site [ion binding]; other site 373994009435 G-X-G motif; other site 373994009436 Response regulator receiver domain; Region: Response_reg; pfam00072 373994009437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994009438 active site 373994009439 phosphorylation site [posttranslational modification] 373994009440 intermolecular recognition site; other site 373994009441 dimerization interface [polypeptide binding]; other site 373994009442 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 373994009443 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 373994009444 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 373994009445 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 373994009446 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 373994009447 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 373994009448 YcfA-like protein; Region: YcfA; pfam07927 373994009449 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 373994009450 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 373994009451 dimer interface [polypeptide binding]; other site 373994009452 PYR/PP interface [polypeptide binding]; other site 373994009453 TPP binding site [chemical binding]; other site 373994009454 substrate binding site [chemical binding]; other site 373994009455 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 373994009456 Domain of unknown function; Region: EKR; pfam10371 373994009457 4Fe-4S binding domain; Region: Fer4_6; pfam12837 373994009458 4Fe-4S binding domain; Region: Fer4; pfam00037 373994009459 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 373994009460 TPP-binding site [chemical binding]; other site 373994009461 dimer interface [polypeptide binding]; other site 373994009462 Conserved TM helix; Region: TM_helix; pfam05552 373994009463 Conserved TM helix; Region: TM_helix; pfam05552 373994009464 Conserved TM helix; Region: TM_helix; pfam05552 373994009465 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 373994009466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994009467 NAD(P) binding site [chemical binding]; other site 373994009468 active site 373994009469 Probable transposase; Region: OrfB_IS605; pfam01385 373994009470 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 373994009471 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994009472 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 373994009473 putative active site [active] 373994009474 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 373994009475 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 373994009476 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 373994009477 N- and C-terminal domain interface [polypeptide binding]; other site 373994009478 active site 373994009479 MgATP binding site [chemical binding]; other site 373994009480 catalytic site [active] 373994009481 metal binding site [ion binding]; metal-binding site 373994009482 glycerol binding site [chemical binding]; other site 373994009483 homotetramer interface [polypeptide binding]; other site 373994009484 homodimer interface [polypeptide binding]; other site 373994009485 FBP binding site [chemical binding]; other site 373994009486 protein IIAGlc interface [polypeptide binding]; other site 373994009487 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 373994009488 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373994009489 Soluble P-type ATPase [General function prediction only]; Region: COG4087 373994009490 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 373994009491 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 373994009492 DNA binding residues [nucleotide binding] 373994009493 dimer interface [polypeptide binding]; other site 373994009494 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 373994009495 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 373994009496 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 373994009497 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 373994009498 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 373994009499 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 373994009500 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 373994009501 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 373994009502 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 373994009503 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 373994009504 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 373994009505 active site 373994009506 PHP Thumb interface [polypeptide binding]; other site 373994009507 metal binding site [ion binding]; metal-binding site 373994009508 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 373994009509 protein-splicing catalytic site; other site 373994009510 thioester formation/cholesterol transfer; other site 373994009511 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 373994009512 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 373994009513 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 373994009514 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 373994009515 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 373994009516 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 373994009517 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 373994009518 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 373994009519 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 373994009520 HD domain; Region: HD_4; pfam13328 373994009521 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 373994009522 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 373994009523 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 373994009524 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 373994009525 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 373994009526 active site 373994009527 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 373994009528 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 373994009529 NADP binding site [chemical binding]; other site 373994009530 active site 373994009531 putative substrate binding site [chemical binding]; other site 373994009532 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994009533 putative active site [active] 373994009534 TPR repeat; Region: TPR_11; pfam13414 373994009535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009536 binding surface 373994009537 TPR motif; other site 373994009538 TPR repeat; Region: TPR_11; pfam13414 373994009539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009540 binding surface 373994009541 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373994009542 TPR motif; other site 373994009543 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994009544 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009545 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009546 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 373994009547 EamA-like transporter family; Region: EamA; cl17759 373994009548 EamA-like transporter family; Region: EamA; cl17759 373994009549 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 373994009550 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 373994009551 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 373994009552 ResB-like family; Region: ResB; pfam05140 373994009553 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 373994009554 Uncharacterized conserved protein [Function unknown]; Region: COG3937 373994009555 YCII-related domain; Region: YCII; cl00999 373994009556 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 373994009557 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 373994009558 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 373994009559 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994009560 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994009561 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994009562 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994009563 ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020 373994009564 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cl01843 373994009565 putative multimerization interface [polypeptide binding]; other site 373994009566 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 373994009567 putative multimerization interface [polypeptide binding]; other site 373994009568 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994009569 ligand binding site [chemical binding]; other site 373994009570 flexible hinge region; other site 373994009571 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 373994009572 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 373994009573 putative active site [active] 373994009574 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994009575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994009576 Walker A/P-loop; other site 373994009577 ATP binding site [chemical binding]; other site 373994009578 Q-loop/lid; other site 373994009579 ABC transporter signature motif; other site 373994009580 Walker B; other site 373994009581 D-loop; other site 373994009582 H-loop/switch region; other site 373994009583 HlyD family secretion protein; Region: HlyD; pfam00529 373994009584 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994009585 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994009586 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 373994009587 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 373994009588 Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559 373994009589 ATP-grasp ribosomal peptide maturase, MvdC family; Region: ATPgraspMvdC; TIGR04185 373994009590 ATP-grasp domain; Region: ATP-grasp_4; cl17255 373994009591 ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184 373994009592 ATP-grasp domain; Region: ATP-grasp_4; cl17255 373994009593 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 373994009594 active site 373994009595 catalytic triad [active] 373994009596 oxyanion hole [active] 373994009597 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 373994009598 Fatty acid desaturase; Region: FA_desaturase; pfam00487 373994009599 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 373994009600 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 373994009601 multimerization interface [polypeptide binding]; other site 373994009602 RbcX protein; Region: RcbX; pfam02341 373994009603 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 373994009604 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 373994009605 homodimer interface [polypeptide binding]; other site 373994009606 active site 373994009607 heterodimer interface [polypeptide binding]; other site 373994009608 catalytic residue [active] 373994009609 metal binding site [ion binding]; metal-binding site 373994009610 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 373994009611 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 373994009612 oligomerization interface [polypeptide binding]; other site 373994009613 active site 373994009614 metal binding site [ion binding]; metal-binding site 373994009615 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 373994009616 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 373994009617 ligand binding site [chemical binding]; other site 373994009618 NAD binding site [chemical binding]; other site 373994009619 dimerization interface [polypeptide binding]; other site 373994009620 catalytic site [active] 373994009621 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 373994009622 putative L-serine binding site [chemical binding]; other site 373994009623 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 373994009624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994009625 S-adenosylmethionine binding site [chemical binding]; other site 373994009626 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 373994009627 ligand binding site [chemical binding]; other site 373994009628 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 373994009629 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 373994009630 catalytic residues [active] 373994009631 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 373994009632 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 373994009633 NAD(P) binding site [chemical binding]; other site 373994009634 homotetramer interface [polypeptide binding]; other site 373994009635 homodimer interface [polypeptide binding]; other site 373994009636 active site 373994009637 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 373994009638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 373994009639 DNA polymerase III subunit delta; Validated; Region: PRK07452 373994009640 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 373994009641 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 373994009642 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994009643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994009644 DNA binding residues [nucleotide binding] 373994009645 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 373994009646 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 373994009647 glycogen binding site [chemical binding]; other site 373994009648 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 373994009649 active site 373994009650 catalytic site [active] 373994009651 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 373994009652 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994009653 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994009654 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994009655 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994009656 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 373994009657 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 373994009658 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 373994009659 trimer interface [polypeptide binding]; other site 373994009660 active site 373994009661 substrate binding site [chemical binding]; other site 373994009662 CoA binding site [chemical binding]; other site 373994009663 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373994009664 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994009665 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 373994009666 putative ADP-binding pocket [chemical binding]; other site 373994009667 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994009668 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373994009669 extended (e) SDRs; Region: SDR_e; cd08946 373994009670 NAD(P) binding site [chemical binding]; other site 373994009671 active site 373994009672 substrate binding site [chemical binding]; other site 373994009673 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994009674 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994009675 active site 373994009676 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 373994009677 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 373994009678 O-Antigen ligase; Region: Wzy_C; pfam04932 373994009679 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994009680 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 373994009681 DXD motif; other site 373994009682 putative acyl transferase; Provisional; Region: PRK10191 373994009683 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 373994009684 trimer interface [polypeptide binding]; other site 373994009685 active site 373994009686 substrate binding site [chemical binding]; other site 373994009687 CoA binding site [chemical binding]; other site 373994009688 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 373994009689 Chain length determinant protein; Region: Wzz; pfam02706 373994009690 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 373994009691 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994009692 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 373994009693 Bacterial sugar transferase; Region: Bac_transf; pfam02397 373994009694 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 373994009695 MPN+ (JAMM) motif; other site 373994009696 Zinc-binding site [ion binding]; other site 373994009697 hypothetical protein; Validated; Region: PRK07411 373994009698 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 373994009699 ATP binding site [chemical binding]; other site 373994009700 substrate interface [chemical binding]; other site 373994009701 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 373994009702 active site residue [active] 373994009703 WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998 373994009704 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994009705 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009706 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009707 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994009708 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009709 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009710 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009711 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009712 AAA ATPase domain; Region: AAA_16; pfam13191 373994009713 AAA domain; Region: AAA_22; pfam13401 373994009714 Walker A motif; other site 373994009715 ATP binding site [chemical binding]; other site 373994009716 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 373994009717 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 373994009718 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 373994009719 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 373994009720 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 373994009721 beta-phosphoglucomutase; Region: bPGM; TIGR01990 373994009722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994009723 S-layer homology domain; Region: SLH; pfam00395 373994009724 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 373994009725 glycine dehydrogenase; Provisional; Region: PRK05367 373994009726 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 373994009727 tetramer interface [polypeptide binding]; other site 373994009728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994009729 catalytic residue [active] 373994009730 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 373994009731 tetramer interface [polypeptide binding]; other site 373994009732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994009733 catalytic residue [active] 373994009734 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 373994009735 lipoyl attachment site [posttranslational modification]; other site 373994009736 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 373994009737 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 373994009738 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 373994009739 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 373994009740 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994009741 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009742 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994009743 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 373994009744 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 373994009745 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 373994009746 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 373994009747 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 373994009748 Walker A/P-loop; other site 373994009749 ATP binding site [chemical binding]; other site 373994009750 Q-loop/lid; other site 373994009751 ABC transporter signature motif; other site 373994009752 Walker B; other site 373994009753 D-loop; other site 373994009754 H-loop/switch region; other site 373994009755 TOBE domain; Region: TOBE_2; pfam08402 373994009756 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 373994009757 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 373994009758 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 373994009759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994009760 dimer interface [polypeptide binding]; other site 373994009761 conserved gate region; other site 373994009762 putative PBP binding loops; other site 373994009763 ABC-ATPase subunit interface; other site 373994009764 sucrose synthase; Region: sucr_synth; TIGR02470 373994009765 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 373994009766 putative ADP-binding pocket [chemical binding]; other site 373994009767 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994009768 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994009769 TPR repeat; Region: TPR_11; pfam13414 373994009770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009771 binding surface 373994009772 TPR motif; other site 373994009773 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373994009774 TPR repeat; Region: TPR_11; pfam13414 373994009775 Tetratricopeptide repeat; Region: TPR_1; pfam00515 373994009776 TPR repeat; Region: TPR_11; pfam13414 373994009777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009778 binding surface 373994009779 TPR motif; other site 373994009780 Cytochrome c; Region: Cytochrom_C; cl11414 373994009781 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 373994009782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994009783 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 373994009784 Coenzyme A binding pocket [chemical binding]; other site 373994009785 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 373994009786 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 373994009787 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373994009788 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373994009789 tellurite resistance protein terB; Region: terB; cd07176 373994009790 putative metal binding site [ion binding]; other site 373994009791 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 373994009792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 373994009793 Ion channel; Region: Ion_trans_2; pfam07885 373994009794 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 373994009795 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 373994009796 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 373994009797 dimer interface [polypeptide binding]; other site 373994009798 ADP-ribose binding site [chemical binding]; other site 373994009799 active site 373994009800 nudix motif; other site 373994009801 metal binding site [ion binding]; metal-binding site 373994009802 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 373994009803 catalytic center binding site [active] 373994009804 ATP binding site [chemical binding]; other site 373994009805 Transglycosylase; Region: Transgly; pfam00912 373994009806 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 373994009807 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 373994009808 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 373994009809 tellurium resistance terB-like protein; Region: terB_like; cd07177 373994009810 metal binding site [ion binding]; metal-binding site 373994009811 16S rRNA methyltransferase B; Provisional; Region: PRK14901 373994009812 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 373994009813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994009814 S-adenosylmethionine binding site [chemical binding]; other site 373994009815 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 373994009816 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 373994009817 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 373994009818 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 373994009819 Protein kinase domain; Region: Pkinase; pfam00069 373994009820 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994009821 active site 373994009822 ATP binding site [chemical binding]; other site 373994009823 substrate binding site [chemical binding]; other site 373994009824 activation loop (A-loop); other site 373994009825 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009826 binding surface 373994009827 TPR motif; other site 373994009828 TPR repeat; Region: TPR_11; pfam13414 373994009829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009830 binding surface 373994009831 TPR motif; other site 373994009832 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 373994009833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009834 binding surface 373994009835 TPR motif; other site 373994009836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009837 binding surface 373994009838 TPR motif; other site 373994009839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009840 binding surface 373994009841 TPR motif; other site 373994009842 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 373994009843 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 373994009844 light-harvesting-like protein 3; Provisional; Region: PLN00014 373994009845 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 373994009846 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 373994009847 Walker A/P-loop; other site 373994009848 ATP binding site [chemical binding]; other site 373994009849 Q-loop/lid; other site 373994009850 ABC transporter signature motif; other site 373994009851 Walker B; other site 373994009852 D-loop; other site 373994009853 H-loop/switch region; other site 373994009854 DevC protein; Region: devC; TIGR01185 373994009855 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994009856 FtsX-like permease family; Region: FtsX; pfam02687 373994009857 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 373994009858 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 373994009859 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994009860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994009861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994009862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 373994009863 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 373994009864 Zn2+ binding site [ion binding]; other site 373994009865 Mg2+ binding site [ion binding]; other site 373994009866 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994009867 Coenzyme A binding pocket [chemical binding]; other site 373994009868 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 373994009869 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 373994009870 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 373994009871 HEAT repeats; Region: HEAT_2; pfam13646 373994009872 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 373994009873 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 373994009874 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 373994009875 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 373994009876 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 373994009877 phycocyanin alpha subunit; Reviewed; Region: cpcA; CHL00170 373994009878 phycocyanin beta subunit; Reviewed; Region: cpcB; CHL00171 373994009879 HEAT repeats; Region: HEAT_2; pfam13646 373994009880 HEAT repeats; Region: HEAT_2; pfam13646 373994009881 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 373994009882 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 373994009883 Phycobilisome protein; Region: Phycobilisome; cl08227 373994009884 Phycobilisome protein; Region: Phycobilisome; cl08227 373994009885 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 373994009886 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373994009887 RNA binding surface [nucleotide binding]; other site 373994009888 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 373994009889 active site 373994009890 Response regulator receiver domain; Region: Response_reg; pfam00072 373994009891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994009892 active site 373994009893 phosphorylation site [posttranslational modification] 373994009894 intermolecular recognition site; other site 373994009895 dimerization interface [polypeptide binding]; other site 373994009896 HEAT repeats; Region: HEAT_2; pfam13646 373994009897 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 373994009898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009899 binding surface 373994009900 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373994009901 TPR motif; other site 373994009902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009903 binding surface 373994009904 TPR motif; other site 373994009905 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 373994009906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009907 binding surface 373994009908 TPR motif; other site 373994009909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994009910 binding surface 373994009911 TPR motif; other site 373994009912 CHAT domain; Region: CHAT; pfam12770 373994009913 Response regulator receiver domain; Region: Response_reg; pfam00072 373994009914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994009915 active site 373994009916 phosphorylation site [posttranslational modification] 373994009917 intermolecular recognition site; other site 373994009918 dimerization interface [polypeptide binding]; other site 373994009919 Response regulator receiver domain; Region: Response_reg; pfam00072 373994009920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994009921 active site 373994009922 phosphorylation site [posttranslational modification] 373994009923 intermolecular recognition site; other site 373994009924 dimerization interface [polypeptide binding]; other site 373994009925 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 373994009926 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994009927 dimerization interface [polypeptide binding]; other site 373994009928 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994009929 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994009930 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994009931 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994009932 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 373994009933 dimerization interface [polypeptide binding]; other site 373994009934 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373994009935 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373994009936 dimer interface [polypeptide binding]; other site 373994009937 putative CheW interface [polypeptide binding]; other site 373994009938 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 373994009939 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373994009940 putative binding surface; other site 373994009941 active site 373994009942 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 373994009943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994009944 ATP binding site [chemical binding]; other site 373994009945 Mg2+ binding site [ion binding]; other site 373994009946 G-X-G motif; other site 373994009947 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 373994009948 Response regulator receiver domain; Region: Response_reg; pfam00072 373994009949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994009950 active site 373994009951 phosphorylation site [posttranslational modification] 373994009952 intermolecular recognition site; other site 373994009953 dimerization interface [polypeptide binding]; other site 373994009954 HEAT repeats; Region: HEAT_2; pfam13646 373994009955 HEAT repeats; Region: HEAT_2; pfam13646 373994009956 HEAT repeats; Region: HEAT_2; pfam13646 373994009957 HEAT-like repeat; Region: HEAT_EZ; pfam13513 373994009958 HEAT repeats; Region: HEAT_2; pfam13646 373994009959 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 373994009960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994009961 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373994009962 NAD(P) binding site [chemical binding]; other site 373994009963 active site 373994009964 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 373994009965 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 373994009966 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 373994009967 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 373994009968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 373994009969 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994009970 dimerization interface [polypeptide binding]; other site 373994009971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994009972 putative active site [active] 373994009973 heme pocket [chemical binding]; other site 373994009974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994009975 dimer interface [polypeptide binding]; other site 373994009976 phosphorylation site [posttranslational modification] 373994009977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994009978 ATP binding site [chemical binding]; other site 373994009979 Mg2+ binding site [ion binding]; other site 373994009980 G-X-G motif; other site 373994009981 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 373994009982 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 373994009983 active site 373994009984 Zn binding site [ion binding]; other site 373994009985 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 373994009986 MoaE interaction surface [polypeptide binding]; other site 373994009987 MoeB interaction surface [polypeptide binding]; other site 373994009988 thiocarboxylated glycine; other site 373994009989 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 373994009990 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 373994009991 Cna protein B-type domain; Region: Cna_B; pfam05738 373994009992 Right handed beta helix region; Region: Beta_helix; pfam13229 373994009993 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 373994009994 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 373994009995 ligand binding site [chemical binding]; other site 373994009996 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 373994009997 conserved repeat domain; Region: B_ant_repeat; TIGR01451 373994009998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 373994009999 threonine synthase; Validated; Region: PRK07591 373994010000 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 373994010001 homodimer interface [polypeptide binding]; other site 373994010002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994010003 catalytic residue [active] 373994010004 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 373994010005 MoaE interaction surface [polypeptide binding]; other site 373994010006 MoeB interaction surface [polypeptide binding]; other site 373994010007 thiocarboxylated glycine; other site 373994010008 S-layer homology domain; Region: SLH; pfam00395 373994010009 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 373994010010 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 373994010011 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 373994010012 TM2 domain; Region: TM2; cl00984 373994010013 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 373994010014 diiron binding motif [ion binding]; other site 373994010015 YGGT family; Region: YGGT; pfam02325 373994010016 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373994010017 active site 373994010018 carotene isomerase; Region: carot_isom; TIGR02730 373994010019 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994010020 hydroxyglutarate oxidase; Provisional; Region: PRK11728 373994010021 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994010022 putative active site [active] 373994010023 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 373994010024 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 373994010025 active site 373994010026 catalytic site [active] 373994010027 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 373994010028 calcium/proton exchanger (cax); Region: cax; TIGR00378 373994010029 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373994010030 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373994010031 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994010032 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994010033 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994010034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994010035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994010036 dimer interface [polypeptide binding]; other site 373994010037 phosphorylation site [posttranslational modification] 373994010038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994010039 ATP binding site [chemical binding]; other site 373994010040 Mg2+ binding site [ion binding]; other site 373994010041 G-X-G motif; other site 373994010042 MltA specific insert domain; Region: MltA; pfam03562 373994010043 3D domain; Region: 3D; pfam06725 373994010044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 373994010045 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 373994010046 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 373994010047 trimer interface [polypeptide binding]; other site 373994010048 active site 373994010049 UDP-GlcNAc binding site [chemical binding]; other site 373994010050 lipid binding site [chemical binding]; lipid-binding site 373994010051 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 373994010052 Cysteine-rich domain; Region: CCG; pfam02754 373994010053 Cysteine-rich domain; Region: CCG; pfam02754 373994010054 acyl carrier protein; Provisional; Region: acpP; PRK00982 373994010055 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 373994010056 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 373994010057 dimer interface [polypeptide binding]; other site 373994010058 active site 373994010059 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 373994010060 transketolase; Region: PLN02790 373994010061 TPP-binding site [chemical binding]; other site 373994010062 dimer interface [polypeptide binding]; other site 373994010063 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 373994010064 PYR/PP interface [polypeptide binding]; other site 373994010065 dimer interface [polypeptide binding]; other site 373994010066 TPP binding site [chemical binding]; other site 373994010067 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 373994010068 CHAT domain; Region: CHAT; cl17868 373994010069 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994010070 CHASE2 domain; Region: CHASE2; pfam05226 373994010071 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 373994010072 oligomeric interface; other site 373994010073 putative active site [active] 373994010074 homodimer interface [polypeptide binding]; other site 373994010075 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 373994010076 Fatty acid desaturase; Region: FA_desaturase; pfam00487 373994010077 Di-iron ligands [ion binding]; other site 373994010078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994010079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994010080 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 373994010081 active site 373994010082 catalytic residues [active] 373994010083 DNA binding site [nucleotide binding] 373994010084 Int/Topo IB signature motif; other site 373994010085 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 373994010086 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 373994010087 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 373994010088 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 373994010089 DHH family; Region: DHH; pfam01368 373994010090 FOG: CBS domain [General function prediction only]; Region: COG0517 373994010091 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 373994010092 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 373994010093 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 373994010094 active site 373994010095 NTP binding site [chemical binding]; other site 373994010096 metal binding triad [ion binding]; metal-binding site 373994010097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994010098 Coenzyme A binding pocket [chemical binding]; other site 373994010099 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 373994010100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994010101 Coenzyme A binding pocket [chemical binding]; other site 373994010102 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 373994010103 classical (c) SDRs; Region: SDR_c; cd05233 373994010104 NAD(P) binding site [chemical binding]; other site 373994010105 active site 373994010106 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 373994010107 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373994010108 Walker A/P-loop; other site 373994010109 ATP binding site [chemical binding]; other site 373994010110 Q-loop/lid; other site 373994010111 ABC transporter signature motif; other site 373994010112 Walker B; other site 373994010113 D-loop; other site 373994010114 H-loop/switch region; other site 373994010115 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 373994010116 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373994010117 Walker A/P-loop; other site 373994010118 ATP binding site [chemical binding]; other site 373994010119 Q-loop/lid; other site 373994010120 ABC transporter signature motif; other site 373994010121 Walker B; other site 373994010122 D-loop; other site 373994010123 H-loop/switch region; other site 373994010124 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 373994010125 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 373994010126 HD domain; Region: HD_4; pfam13328 373994010127 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 373994010128 synthetase active site [active] 373994010129 NTP binding site [chemical binding]; other site 373994010130 metal binding site [ion binding]; metal-binding site 373994010131 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 373994010132 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 373994010133 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 373994010134 EamA-like transporter family; Region: EamA; pfam00892 373994010135 hydrolase, alpha/beta fold family protein; Region: PLN02824 373994010136 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994010137 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 373994010138 trimer interface [polypeptide binding]; other site 373994010139 dimer interface [polypeptide binding]; other site 373994010140 putative active site [active] 373994010141 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 373994010142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373994010143 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994010144 HEAT repeats; Region: HEAT_2; pfam13646 373994010145 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994010146 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994010147 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994010148 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994010149 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994010150 CHAT domain; Region: CHAT; cl17868 373994010151 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 373994010152 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 373994010153 active site 373994010154 Ca binding site [ion binding]; other site 373994010155 catalytic site [active] 373994010156 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 373994010157 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 373994010158 Phycobilisome protein; Region: Phycobilisome; cl08227 373994010159 Phycobilisome protein; Region: Phycobilisome; cl08227 373994010160 phycobillisome linker protein; Region: apcE; CHL00091 373994010161 Phycobilisome protein; Region: Phycobilisome; cl08227 373994010162 Phycobilisome protein; Region: Phycobilisome; cl08227 373994010163 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 373994010164 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 373994010165 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 373994010166 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 373994010167 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 373994010168 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 373994010169 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 373994010170 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 373994010171 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 373994010172 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 373994010173 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373994010174 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373994010175 DNA binding residues [nucleotide binding] 373994010176 putative anti-sigmaE protein; Provisional; Region: PRK13920 373994010177 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 373994010178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994010179 putative substrate translocation pore; other site 373994010180 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 373994010181 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 373994010182 Response regulator receiver domain; Region: Response_reg; pfam00072 373994010183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994010184 active site 373994010185 phosphorylation site [posttranslational modification] 373994010186 intermolecular recognition site; other site 373994010187 dimerization interface [polypeptide binding]; other site 373994010188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994010189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994010190 phosphorylation site [posttranslational modification] 373994010191 dimer interface [polypeptide binding]; other site 373994010192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994010193 ATP binding site [chemical binding]; other site 373994010194 Mg2+ binding site [ion binding]; other site 373994010195 G-X-G motif; other site 373994010196 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994010197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994010198 S-adenosylmethionine binding site [chemical binding]; other site 373994010199 ATP synthase I chain; Region: ATP_synt_I; pfam03899 373994010200 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 373994010201 ATP synthase CF0 A subunit; Region: atpI; CHL00046 373994010202 ATP synthase CF0 C subunit; Region: atpH; CHL00061 373994010203 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 373994010204 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 373994010205 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 373994010206 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 373994010207 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 373994010208 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 373994010209 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 373994010210 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 373994010211 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 373994010212 beta subunit interaction interface [polypeptide binding]; other site 373994010213 Walker A motif; other site 373994010214 ATP binding site [chemical binding]; other site 373994010215 Walker B motif; other site 373994010216 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 373994010217 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 373994010218 core domain interface [polypeptide binding]; other site 373994010219 delta subunit interface [polypeptide binding]; other site 373994010220 epsilon subunit interface [polypeptide binding]; other site 373994010221 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 373994010222 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 373994010223 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 373994010224 catalytic site [active] 373994010225 putative active site [active] 373994010226 putative substrate binding site [chemical binding]; other site 373994010227 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 373994010228 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 373994010229 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994010230 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994010231 active site 373994010232 ATP binding site [chemical binding]; other site 373994010233 substrate binding site [chemical binding]; other site 373994010234 activation loop (A-loop); other site 373994010235 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 373994010236 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994010237 TPR repeat; Region: TPR_11; pfam13414 373994010238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010239 binding surface 373994010240 TPR motif; other site 373994010241 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 373994010242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010243 binding surface 373994010244 TPR motif; other site 373994010245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010246 binding surface 373994010247 TPR motif; other site 373994010248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010249 binding surface 373994010250 TPR motif; other site 373994010251 TPR repeat; Region: TPR_11; pfam13414 373994010252 Circadian oscillating protein COP23; Region: COP23; pfam14218 373994010253 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 373994010254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994010255 putative substrate translocation pore; other site 373994010256 heterocyst differentiation control protein; Reviewed; Region: hetR; PRK13245 373994010257 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 373994010258 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 373994010259 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373994010260 RNA binding surface [nucleotide binding]; other site 373994010261 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994010262 TPR repeat; Region: TPR_11; pfam13414 373994010263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010264 binding surface 373994010265 TPR motif; other site 373994010266 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994010267 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994010268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010269 binding surface 373994010270 TPR motif; other site 373994010271 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994010272 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994010273 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994010274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010275 binding surface 373994010276 TPR motif; other site 373994010277 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994010278 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994010279 Cytochrome P450; Region: p450; pfam00067 373994010280 Protein of unknown function (DUF1399); Region: DUF1399; pfam07173 373994010281 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 373994010282 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373994010283 AAA ATPase domain; Region: AAA_16; pfam13191 373994010284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 373994010285 TPR motif; other site 373994010286 binding surface 373994010287 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994010288 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994010289 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994010290 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994010291 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994010292 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 373994010293 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994010294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 373994010295 active site 373994010296 phosphorylation site [posttranslational modification] 373994010297 intermolecular recognition site; other site 373994010298 dimerization interface [polypeptide binding]; other site 373994010299 CHAT domain; Region: CHAT; cl17868 373994010300 PBP superfamily domain; Region: PBP_like_2; pfam12849 373994010301 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994010302 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 373994010303 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994010304 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 373994010305 Walker A/P-loop; other site 373994010306 ATP binding site [chemical binding]; other site 373994010307 Q-loop/lid; other site 373994010308 ABC transporter signature motif; other site 373994010309 Walker B; other site 373994010310 D-loop; other site 373994010311 H-loop/switch region; other site 373994010312 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 373994010313 HflK protein; Region: hflK; TIGR01933 373994010314 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 373994010315 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 373994010316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994010317 Walker A/P-loop; other site 373994010318 ATP binding site [chemical binding]; other site 373994010319 Q-loop/lid; other site 373994010320 ABC transporter signature motif; other site 373994010321 Walker B; other site 373994010322 D-loop; other site 373994010323 H-loop/switch region; other site 373994010324 ABC transporter; Region: ABC_tran_2; pfam12848 373994010325 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 373994010326 Leucine-rich repeats, typical (most populated) subfamily; Region: LRR_TYP; cl15310 373994010327 Leucine rich repeat; Region: LRR_8; pfam13855 373994010328 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 373994010329 active site residue [active] 373994010330 Leucine rich repeat; Region: LRR_8; pfam13855 373994010331 Leucine rich repeat; Region: LRR_8; pfam13855 373994010332 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 373994010333 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373994010334 ABC-ATPase subunit interface; other site 373994010335 dimer interface [polypeptide binding]; other site 373994010336 putative PBP binding regions; other site 373994010337 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 373994010338 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 373994010339 putative ligand binding site [chemical binding]; other site 373994010340 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 373994010341 dimer interface [polypeptide binding]; other site 373994010342 [2Fe-2S] cluster binding site [ion binding]; other site 373994010343 cobalt transport protein CbiM; Validated; Region: PRK08319 373994010344 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 373994010345 cobalt transport protein CbiN; Provisional; Region: PRK02898 373994010346 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 373994010347 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 373994010348 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 373994010349 Walker A/P-loop; other site 373994010350 ATP binding site [chemical binding]; other site 373994010351 Q-loop/lid; other site 373994010352 ABC transporter signature motif; other site 373994010353 Walker B; other site 373994010354 D-loop; other site 373994010355 H-loop/switch region; other site 373994010356 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 373994010357 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 373994010358 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 373994010359 ATP-grasp domain; Region: ATP-grasp; pfam02222 373994010360 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373994010361 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 373994010362 KGK domain; Region: KGK; pfam08872 373994010363 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 373994010364 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373994010365 G1 box; other site 373994010366 GTP/Mg2+ binding site [chemical binding]; other site 373994010367 G2 box; other site 373994010368 Switch I region; other site 373994010369 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373994010370 G3 box; other site 373994010371 Switch II region; other site 373994010372 G4 box; other site 373994010373 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 373994010374 trimer interface [polypeptide binding]; other site 373994010375 putative Zn binding site [ion binding]; other site 373994010376 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994010377 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994010378 active site 373994010379 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 373994010380 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994010381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994010382 active site 373994010383 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 373994010384 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 373994010385 Walker A/P-loop; other site 373994010386 ATP binding site [chemical binding]; other site 373994010387 Q-loop/lid; other site 373994010388 ABC transporter signature motif; other site 373994010389 Walker B; other site 373994010390 D-loop; other site 373994010391 H-loop/switch region; other site 373994010392 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 373994010393 putative carbohydrate binding site [chemical binding]; other site 373994010394 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 373994010395 ABC-2 type transporter; Region: ABC2_membrane; cl17235 373994010396 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994010397 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994010398 active site 373994010399 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994010400 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 373994010401 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 373994010402 putative ADP-binding pocket [chemical binding]; other site 373994010403 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 373994010404 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994010405 putative active site [active] 373994010406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 373994010407 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373994010408 catalytic residue [active] 373994010409 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 373994010410 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 373994010411 nucleotide binding site [chemical binding]; other site 373994010412 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 373994010413 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 373994010414 D-xylulose kinase; Region: XylB; TIGR01312 373994010415 nucleotide binding site [chemical binding]; other site 373994010416 Photosystem I protein M (PsaM); Region: PsaM; pfam07465 373994010417 TPR repeat; Region: TPR_11; pfam13414 373994010418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010419 binding surface 373994010420 TPR motif; other site 373994010421 TPR repeat; Region: TPR_11; pfam13414 373994010422 TPR repeat; Region: TPR_11; pfam13414 373994010423 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 373994010424 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 373994010425 putative C-terminal domain interface [polypeptide binding]; other site 373994010426 putative GSH binding site (G-site) [chemical binding]; other site 373994010427 putative dimer interface [polypeptide binding]; other site 373994010428 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 373994010429 N-terminal domain interface [polypeptide binding]; other site 373994010430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 373994010431 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 373994010432 Predicted membrane protein [Function unknown]; Region: COG3686 373994010433 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 373994010434 Predicted transcriptional regulators [Transcription]; Region: COG1695 373994010435 Transcriptional regulator PadR-like family; Region: PadR; cl17335 373994010436 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 373994010437 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 373994010438 2TM domain; Region: 2TM; pfam13239 373994010439 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 373994010440 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994010441 DRTGG domain; Region: DRTGG; pfam07085 373994010442 enoyl-CoA hydratase; Provisional; Region: PRK06142 373994010443 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 373994010444 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 373994010445 DXD motif; other site 373994010446 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 373994010447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994010448 Walker A motif; other site 373994010449 ATP binding site [chemical binding]; other site 373994010450 Walker B motif; other site 373994010451 arginine finger; other site 373994010452 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 373994010453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010454 binding surface 373994010455 TPR motif; other site 373994010456 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 373994010457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010458 binding surface 373994010459 TPR motif; other site 373994010460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010461 binding surface 373994010462 TPR motif; other site 373994010463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010464 binding surface 373994010465 TPR motif; other site 373994010466 CHAT domain; Region: CHAT; pfam12770 373994010467 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 373994010468 Cytochrome P450; Region: p450; cl12078 373994010469 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 373994010470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 373994010471 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 373994010472 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 373994010473 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 373994010474 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 373994010475 Walker A/P-loop; other site 373994010476 ATP binding site [chemical binding]; other site 373994010477 Q-loop/lid; other site 373994010478 ABC transporter signature motif; other site 373994010479 Walker B; other site 373994010480 D-loop; other site 373994010481 H-loop/switch region; other site 373994010482 muropeptide transporter; Reviewed; Region: ampG; PRK11902 373994010483 muropeptide transporter; Validated; Region: ampG; cl17669 373994010484 Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ValS; COG0525 373994010485 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 373994010486 HIGH motif; other site 373994010487 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 373994010488 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 373994010489 active site 373994010490 KMSKS motif; other site 373994010491 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 373994010492 tRNA binding surface [nucleotide binding]; other site 373994010493 anticodon binding site; other site 373994010494 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 373994010495 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 373994010496 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 373994010497 ABC1 family; Region: ABC1; cl17513 373994010498 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 373994010499 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 373994010500 Walker A/P-loop; other site 373994010501 ATP binding site [chemical binding]; other site 373994010502 Q-loop/lid; other site 373994010503 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 373994010504 ABC transporter signature motif; other site 373994010505 Walker B; other site 373994010506 D-loop; other site 373994010507 H-loop/switch region; other site 373994010508 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 373994010509 Beta-lactamase; Region: Beta-lactamase; pfam00144 373994010510 Amino acid permease; Region: AA_permease_2; pfam13520 373994010511 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994010512 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994010513 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994010514 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994010515 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 373994010516 cyclase homology domain; Region: CHD; cd07302 373994010517 nucleotidyl binding site; other site 373994010518 metal binding site [ion binding]; metal-binding site 373994010519 dimer interface [polypeptide binding]; other site 373994010520 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994010521 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994010522 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994010523 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994010524 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994010525 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994010526 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994010527 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373994010528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994010529 dimer interface [polypeptide binding]; other site 373994010530 conserved gate region; other site 373994010531 putative PBP binding loops; other site 373994010532 ABC-ATPase subunit interface; other site 373994010533 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 373994010534 dinuclear metal binding motif [ion binding]; other site 373994010535 acyl-ACP reductase; Provisional; Region: PRK14982 373994010536 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 373994010537 NAD(P) binding pocket [chemical binding]; other site 373994010538 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 373994010539 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 373994010540 short chain dehydrogenase; Provisional; Region: PRK07454 373994010541 classical (c) SDRs; Region: SDR_c; cd05233 373994010542 NAD(P) binding site [chemical binding]; other site 373994010543 active site 373994010544 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 373994010545 homodecamer interface [polypeptide binding]; other site 373994010546 GTP cyclohydrolase I; Provisional; Region: PLN03044 373994010547 active site 373994010548 putative catalytic site residues [active] 373994010549 zinc binding site [ion binding]; other site 373994010550 GTP-CH-I/GFRP interaction surface; other site 373994010551 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 373994010552 active site 373994010553 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 373994010554 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 373994010555 Peptidase family M50; Region: Peptidase_M50; pfam02163 373994010556 active site 373994010557 putative substrate binding region [chemical binding]; other site 373994010558 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 373994010559 Predicted metal-binding protein [Function unknown]; Region: COG5469 373994010560 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 373994010561 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 373994010562 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 373994010563 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 373994010564 putative dimer interface [polypeptide binding]; other site 373994010565 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 373994010566 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 373994010567 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 373994010568 active site 373994010569 putative homodimer interface [polypeptide binding]; other site 373994010570 SAM binding site [chemical binding]; other site 373994010571 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 373994010572 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 373994010573 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 373994010574 Precorrin-8X methylmutase; Region: CbiC; pfam02570 373994010575 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 373994010576 active site 373994010577 SAM binding site [chemical binding]; other site 373994010578 homodimer interface [polypeptide binding]; other site 373994010579 TrkA-N domain; Region: TrkA_N; pfam02254 373994010580 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 373994010581 Ion transport protein; Region: Ion_trans; pfam00520 373994010582 Ion channel; Region: Ion_trans_2; pfam07885 373994010583 TrkA-N domain; Region: TrkA_N; pfam02254 373994010584 Ion channel; Region: Ion_trans_2; pfam07885 373994010585 TrkA-N domain; Region: TrkA_N; pfam02254 373994010586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994010587 Coenzyme A binding pocket [chemical binding]; other site 373994010588 HD domain; Region: HD_3; pfam13023 373994010589 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 373994010590 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373994010591 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994010592 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994010593 active site 373994010594 ATP binding site [chemical binding]; other site 373994010595 substrate binding site [chemical binding]; other site 373994010596 activation loop (A-loop); other site 373994010597 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994010598 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994010599 active site 373994010600 ATP binding site [chemical binding]; other site 373994010601 substrate binding site [chemical binding]; other site 373994010602 activation loop (A-loop); other site 373994010603 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 373994010604 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 373994010605 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 373994010606 Double zinc ribbon; Region: DZR; pfam12773 373994010607 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994010608 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994010609 active site 373994010610 ATP binding site [chemical binding]; other site 373994010611 substrate binding site [chemical binding]; other site 373994010612 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994010613 substrate binding site [chemical binding]; other site 373994010614 activation loop (A-loop); other site 373994010615 activation loop (A-loop); other site 373994010616 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994010617 structural tetrad; other site 373994010618 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 373994010619 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994010620 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994010621 active site 373994010622 ATP binding site [chemical binding]; other site 373994010623 substrate binding site [chemical binding]; other site 373994010624 activation loop (A-loop); other site 373994010625 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 373994010626 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994010627 structural tetrad; other site 373994010628 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994010629 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994010630 structural tetrad; other site 373994010631 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994010632 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994010633 active site 373994010634 ATP binding site [chemical binding]; other site 373994010635 substrate binding site [chemical binding]; other site 373994010636 activation loop (A-loop); other site 373994010637 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994010638 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994010639 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994010640 structural tetrad; other site 373994010641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010642 TPR repeat; Region: TPR_11; pfam13414 373994010643 binding surface 373994010644 TPR motif; other site 373994010645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010646 TPR motif; other site 373994010647 TPR repeat; Region: TPR_11; pfam13414 373994010648 binding surface 373994010649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994010650 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 373994010651 catalytic site [active] 373994010652 putative active site [active] 373994010653 putative substrate binding site [chemical binding]; other site 373994010654 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994010655 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994010656 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 373994010657 Amidinotransferase; Region: Amidinotransf; cl12043 373994010658 Uncharacterized conserved protein [Function unknown]; Region: COG1915 373994010659 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 373994010660 homodimer interface [polypeptide binding]; other site 373994010661 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 373994010662 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994010663 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373994010664 Trm112p-like protein; Region: Trm112p; cl01066 373994010665 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994010666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994010667 S-adenosylmethionine binding site [chemical binding]; other site 373994010668 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994010669 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994010670 colanic acid exporter; Provisional; Region: PRK10459 373994010671 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 373994010672 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 373994010673 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 373994010674 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373994010675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994010676 NAD(P) binding site [chemical binding]; other site 373994010677 active site 373994010678 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 373994010679 putative ADP-binding pocket [chemical binding]; other site 373994010680 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994010681 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 373994010682 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 373994010683 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 373994010684 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994010685 active site 373994010686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994010687 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 373994010688 O-Antigen ligase; Region: Wzy_C; pfam04932 373994010689 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994010690 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 373994010691 DXD motif; other site 373994010692 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994010693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994010694 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 373994010695 putative acyl transferase; Provisional; Region: PRK10191 373994010696 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 373994010697 trimer interface [polypeptide binding]; other site 373994010698 active site 373994010699 substrate binding site [chemical binding]; other site 373994010700 CoA binding site [chemical binding]; other site 373994010701 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373994010702 Chain length determinant protein; Region: Wzz; pfam02706 373994010703 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 373994010704 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 373994010705 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994010706 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 373994010707 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 373994010708 Bacterial SH3 domain; Region: SH3_3; pfam08239 373994010709 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 373994010710 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373994010711 active site 373994010712 metal binding site [ion binding]; metal-binding site 373994010713 CTP synthetase; Validated; Region: pyrG; PRK05380 373994010714 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 373994010715 Catalytic site [active] 373994010716 active site 373994010717 UTP binding site [chemical binding]; other site 373994010718 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 373994010719 active site 373994010720 putative oxyanion hole; other site 373994010721 catalytic triad [active] 373994010722 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 373994010723 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 373994010724 nucleotide binding site [chemical binding]; other site 373994010725 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 373994010726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994010727 dimer interface [polypeptide binding]; other site 373994010728 conserved gate region; other site 373994010729 ABC-ATPase subunit interface; other site 373994010730 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 373994010731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373994010732 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994010733 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 373994010734 catalytic residues [active] 373994010735 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994010736 putative active site [active] 373994010737 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 373994010738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994010739 S-adenosylmethionine binding site [chemical binding]; other site 373994010740 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 373994010741 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010742 TPR repeat; Region: TPR_11; pfam13414 373994010743 binding surface 373994010744 TPR motif; other site 373994010745 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 373994010746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994010747 binding surface 373994010748 TPR motif; other site 373994010749 Methyltransferase domain; Region: Methyltransf_24; pfam13578 373994010750 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 373994010751 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994010752 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 373994010753 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 373994010754 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994010755 phosphopeptide binding site; other site 373994010756 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994010757 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994010758 active site 373994010759 ATP binding site [chemical binding]; other site 373994010760 substrate binding site [chemical binding]; other site 373994010761 activation loop (A-loop); other site 373994010762 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 373994010763 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 373994010764 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 373994010765 active site 373994010766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994010767 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994010768 putative active site [active] 373994010769 heme pocket [chemical binding]; other site 373994010770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994010771 putative active site [active] 373994010772 heme pocket [chemical binding]; other site 373994010773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994010774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994010775 dimer interface [polypeptide binding]; other site 373994010776 phosphorylation site [posttranslational modification] 373994010777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994010778 ATP binding site [chemical binding]; other site 373994010779 Mg2+ binding site [ion binding]; other site 373994010780 G-X-G motif; other site 373994010781 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 373994010782 pseudouridine synthase; Region: TIGR00093 373994010783 active site 373994010784 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 373994010785 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 373994010786 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373994010787 active site 373994010788 Domain of unknown function DUF21; Region: DUF21; pfam01595 373994010789 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 373994010790 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 373994010791 Transporter associated domain; Region: CorC_HlyC; smart01091 373994010792 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 373994010793 Ligand Binding Site [chemical binding]; other site 373994010794 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 373994010795 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 373994010796 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 373994010797 Mg binding site [ion binding]; other site 373994010798 nucleotide binding site [chemical binding]; other site 373994010799 putative protofilament interface [polypeptide binding]; other site 373994010800 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 373994010801 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 373994010802 active site 373994010803 substrate binding site [chemical binding]; other site 373994010804 metal binding site [ion binding]; metal-binding site 373994010805 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 373994010806 active site 373994010807 dimerization interface [polypeptide binding]; other site 373994010808 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 373994010809 Nitrogen regulatory protein P-II; Region: P-II; smart00938 373994010810 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 373994010811 dimer interface [polypeptide binding]; other site 373994010812 substrate binding site [chemical binding]; other site 373994010813 ATP binding site [chemical binding]; other site 373994010814 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 373994010815 active site 373994010816 catalytic triad [active] 373994010817 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 373994010818 CHAT domain; Region: CHAT; pfam12770 373994010819 SPRY domain; Region: SPRY; cl02614 373994010820 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 373994010821 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 373994010822 putative active site [active] 373994010823 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 373994010824 catalytic triad [active] 373994010825 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 373994010826 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373994010827 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 373994010828 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 373994010829 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 373994010830 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 373994010831 putative active site [active] 373994010832 catalytic site [active] 373994010833 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 373994010834 PLD-like domain; Region: PLDc_2; pfam13091 373994010835 putative active site [active] 373994010836 catalytic site [active] 373994010837 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 373994010838 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 373994010839 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 373994010840 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 373994010841 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 373994010842 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 373994010843 putative active site [active] 373994010844 putative dimer interface [polypeptide binding]; other site 373994010845 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 373994010846 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 373994010847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994010848 S-adenosylmethionine binding site [chemical binding]; other site 373994010849 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 373994010850 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 373994010851 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 373994010852 active site 373994010853 dimer interface [polypeptide binding]; other site 373994010854 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 373994010855 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 373994010856 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 373994010857 Protein kinase domain; Region: Pkinase; pfam00069 373994010858 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994010859 active site 373994010860 ATP binding site [chemical binding]; other site 373994010861 substrate binding site [chemical binding]; other site 373994010862 activation loop (A-loop); other site 373994010863 AAA ATPase domain; Region: AAA_16; pfam13191 373994010864 Predicted ATPase [General function prediction only]; Region: COG3899 373994010865 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994010866 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994010867 PAS domain S-box; Region: sensory_box; TIGR00229 373994010868 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994010869 putative active site [active] 373994010870 heme pocket [chemical binding]; other site 373994010871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994010872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994010873 ATP binding site [chemical binding]; other site 373994010874 Mg2+ binding site [ion binding]; other site 373994010875 G-X-G motif; other site 373994010876 Protein kinase domain; Region: Pkinase; pfam00069 373994010877 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994010878 active site 373994010879 ATP binding site [chemical binding]; other site 373994010880 substrate binding site [chemical binding]; other site 373994010881 activation loop (A-loop); other site 373994010882 AAA ATPase domain; Region: AAA_16; pfam13191 373994010883 Predicted ATPase [General function prediction only]; Region: COG3899 373994010884 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994010885 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994010886 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994010887 GAF domain; Region: GAF; pfam01590 373994010888 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994010889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994010890 ATP binding site [chemical binding]; other site 373994010891 Mg2+ binding site [ion binding]; other site 373994010892 G-X-G motif; other site 373994010893 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 373994010894 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 373994010895 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994010896 Ligand Binding Site [chemical binding]; other site 373994010897 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 373994010898 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 373994010899 active site 373994010900 catalytic triad [active] 373994010901 oxyanion hole [active] 373994010902 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 373994010903 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 373994010904 Alkaline phosphatase homologues; Region: alkPPc; smart00098 373994010905 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 373994010906 active site 373994010907 dimer interface [polypeptide binding]; other site 373994010908 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 373994010909 active site 373994010910 catalytic triad [active] 373994010911 AAA-like domain; Region: AAA_10; pfam12846 373994010912 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 373994010913 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 373994010914 putative active site [active] 373994010915 catalytic triad [active] 373994010916 putative dimer interface [polypeptide binding]; other site 373994010917 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 373994010918 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 373994010919 FOG: CBS domain [General function prediction only]; Region: COG0517 373994010920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994010921 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994010922 putative active site [active] 373994010923 heme pocket [chemical binding]; other site 373994010924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994010925 heme pocket [chemical binding]; other site 373994010926 putative active site [active] 373994010927 PAS domain S-box; Region: sensory_box; TIGR00229 373994010928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994010929 putative active site [active] 373994010930 heme pocket [chemical binding]; other site 373994010931 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 373994010932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994010933 putative active site [active] 373994010934 heme pocket [chemical binding]; other site 373994010935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994010936 dimer interface [polypeptide binding]; other site 373994010937 phosphorylation site [posttranslational modification] 373994010938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994010939 ATP binding site [chemical binding]; other site 373994010940 Mg2+ binding site [ion binding]; other site 373994010941 G-X-G motif; other site 373994010942 Response regulator receiver domain; Region: Response_reg; pfam00072 373994010943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994010944 active site 373994010945 phosphorylation site [posttranslational modification] 373994010946 intermolecular recognition site; other site 373994010947 dimerization interface [polypeptide binding]; other site 373994010948 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994010949 Ligand Binding Site [chemical binding]; other site 373994010950 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994010951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994010952 active site 373994010953 phosphorylation site [posttranslational modification] 373994010954 intermolecular recognition site; other site 373994010955 dimerization interface [polypeptide binding]; other site 373994010956 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994010957 DNA binding site [nucleotide binding] 373994010958 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 373994010959 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 373994010960 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 373994010961 G1 box; other site 373994010962 GTP/Mg2+ binding site [chemical binding]; other site 373994010963 Switch I region; other site 373994010964 G2 box; other site 373994010965 Switch II region; other site 373994010966 G3 box; other site 373994010967 G4 box; other site 373994010968 G5 box; other site 373994010969 Domain of unknown function (DUF697); Region: DUF697; pfam05128 373994010970 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 373994010971 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 373994010972 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 373994010973 putative active site [active] 373994010974 putative NTP binding site [chemical binding]; other site 373994010975 putative nucleic acid binding site [nucleotide binding]; other site 373994010976 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 373994010977 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 373994010978 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 373994010979 active site 373994010980 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373994010981 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373994010982 active site 373994010983 catalytic tetrad [active] 373994010984 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 373994010985 pentamer interface [polypeptide binding]; other site 373994010986 dodecaamer interface [polypeptide binding]; other site 373994010987 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 373994010988 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 373994010989 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 373994010990 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 373994010991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994010992 Coenzyme A binding pocket [chemical binding]; other site 373994010993 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994010994 putative active site [active] 373994010995 Proline dehydrogenase; Region: Pro_dh; pfam01619 373994010996 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 373994010997 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 373994010998 Glutamate binding site [chemical binding]; other site 373994010999 homodimer interface [polypeptide binding]; other site 373994011000 NAD binding site [chemical binding]; other site 373994011001 catalytic residues [active] 373994011002 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 373994011003 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994011004 active site 373994011005 ATP binding site [chemical binding]; other site 373994011006 substrate binding site [chemical binding]; other site 373994011007 activation loop (A-loop); other site 373994011008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994011009 binding surface 373994011010 TPR motif; other site 373994011011 TPR repeat; Region: TPR_11; pfam13414 373994011012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994011013 binding surface 373994011014 TPR motif; other site 373994011015 TPR repeat; Region: TPR_11; pfam13414 373994011016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994011017 binding surface 373994011018 TPR repeat; Region: TPR_11; pfam13414 373994011019 TPR motif; other site 373994011020 TPR repeat; Region: TPR_11; pfam13414 373994011021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994011022 binding surface 373994011023 TPR motif; other site 373994011024 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994011025 hypothetical protein; Reviewed; Region: PRK12275 373994011026 four helix bundle protein; Region: TIGR02436 373994011027 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 373994011028 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 373994011029 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 373994011030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 373994011031 Thermostable hemolysin; Region: T_hemolysin; pfam12261 373994011032 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 373994011033 Predicted membrane protein [Function unknown]; Region: COG4244 373994011034 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 373994011035 Permease; Region: Permease; cl00510 373994011036 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 373994011037 Lipoxygenase; Region: Lipoxygenase; pfam00305 373994011038 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 373994011039 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 373994011040 putative C-terminal domain interface [polypeptide binding]; other site 373994011041 putative GSH binding site (G-site) [chemical binding]; other site 373994011042 putative dimer interface [polypeptide binding]; other site 373994011043 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 373994011044 N-terminal domain interface [polypeptide binding]; other site 373994011045 dimer interface [polypeptide binding]; other site 373994011046 substrate binding pocket (H-site) [chemical binding]; other site 373994011047 Uncharacterized conserved protein [Function unknown]; Region: COG2135 373994011048 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 373994011049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994011050 binding surface 373994011051 TPR motif; other site 373994011052 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 373994011053 methionine sulfoxide reductase B; Provisional; Region: PRK00222 373994011054 SelR domain; Region: SelR; pfam01641 373994011055 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 373994011056 putative heme binding site [chemical binding]; other site 373994011057 putative substrate binding site [chemical binding]; other site 373994011058 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 373994011059 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 373994011060 Walker A/P-loop; other site 373994011061 ATP binding site [chemical binding]; other site 373994011062 Q-loop/lid; other site 373994011063 ABC transporter signature motif; other site 373994011064 Walker B; other site 373994011065 D-loop; other site 373994011066 H-loop/switch region; other site 373994011067 DevC protein; Region: devC; TIGR01185 373994011068 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994011069 FtsX-like permease family; Region: FtsX; pfam02687 373994011070 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 373994011071 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994011072 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994011073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994011074 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373994011075 putative substrate translocation pore; other site 373994011076 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994011077 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 373994011078 violacein biosynthesis enzyme VioE; Region: violacein_E; TIGR03650 373994011079 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 373994011080 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 373994011081 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994011082 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 373994011083 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 373994011084 malonyl-CoA binding site [chemical binding]; other site 373994011085 dimer interface [polypeptide binding]; other site 373994011086 active site 373994011087 product binding site; other site 373994011088 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 373994011089 Fatty acid desaturase; Region: FA_desaturase; pfam00487 373994011090 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 373994011091 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 373994011092 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994011093 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994011094 CHAT domain; Region: CHAT; cl17868 373994011095 CHASE2 domain; Region: CHASE2; pfam05226 373994011096 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994011097 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994011098 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994011099 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994011100 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994011101 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994011102 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 373994011103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 373994011104 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994011105 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994011106 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994011107 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994011108 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994011109 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994011110 methionine sulfoxide reductase B; Provisional; Region: PRK00222 373994011111 SelR domain; Region: SelR; pfam01641 373994011112 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 373994011113 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 373994011114 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 373994011115 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 373994011116 active site 373994011117 NACHT domain; Region: NACHT; pfam05729 373994011118 RNA helicase; Region: RNA_helicase; pfam00910 373994011119 HEAT repeats; Region: HEAT_2; pfam13646 373994011120 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 373994011121 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 373994011122 protein binding surface [polypeptide binding]; other site 373994011123 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 373994011124 protein binding surface [polypeptide binding]; other site 373994011125 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 373994011126 protein binding surface [polypeptide binding]; other site 373994011127 HEAT repeats; Region: HEAT_2; pfam13646 373994011128 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994011129 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 373994011130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994011131 ATP binding site [chemical binding]; other site 373994011132 putative Mg++ binding site [ion binding]; other site 373994011133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994011134 nucleotide binding region [chemical binding]; other site 373994011135 ATP-binding site [chemical binding]; other site 373994011136 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 373994011137 Protein of unknown function (DUF790); Region: DUF790; pfam05626 373994011138 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994011139 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994011140 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994011141 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994011142 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994011143 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994011144 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994011145 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994011146 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994011147 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994011148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994011149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994011150 dimer interface [polypeptide binding]; other site 373994011151 phosphorylation site [posttranslational modification] 373994011152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994011153 ATP binding site [chemical binding]; other site 373994011154 Mg2+ binding site [ion binding]; other site 373994011155 G-X-G motif; other site 373994011156 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 373994011157 catalytic core [active] 373994011158 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 373994011159 catalytic core [active] 373994011160 dihydroorotase; Provisional; Region: PRK07369 373994011161 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 373994011162 active site 373994011163 carotene isomerase; Region: carot_isom; TIGR02730 373994011164 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994011165 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 373994011166 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 373994011167 Walker A/P-loop; other site 373994011168 ATP binding site [chemical binding]; other site 373994011169 Q-loop/lid; other site 373994011170 ABC transporter signature motif; other site 373994011171 Walker B; other site 373994011172 D-loop; other site 373994011173 H-loop/switch region; other site 373994011174 mce related protein; Region: MCE; pfam02470 373994011175 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 373994011176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 373994011177 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 373994011178 dimerization interface [polypeptide binding]; other site 373994011179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 373994011180 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 373994011181 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 373994011182 putative dimer interface [polypeptide binding]; other site 373994011183 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 373994011184 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 373994011185 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 373994011186 Putative esterase; Region: Esterase; pfam00756 373994011187 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994011188 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373994011189 protein binding site [polypeptide binding]; other site 373994011190 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994011191 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373994011192 protein binding site [polypeptide binding]; other site 373994011193 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994011194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 373994011195 phosphorylation site [posttranslational modification] 373994011196 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994011197 DNA binding residues [nucleotide binding] 373994011198 dimerization interface [polypeptide binding]; other site 373994011199 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 373994011200 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 373994011201 active site 373994011202 metal binding site [ion binding]; metal-binding site 373994011203 elongation factor G; Reviewed; Region: PRK00007 373994011204 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 373994011205 G1 box; other site 373994011206 putative GEF interaction site [polypeptide binding]; other site 373994011207 GTP/Mg2+ binding site [chemical binding]; other site 373994011208 Switch I region; other site 373994011209 G2 box; other site 373994011210 G3 box; other site 373994011211 Switch II region; other site 373994011212 G4 box; other site 373994011213 G5 box; other site 373994011214 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 373994011215 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 373994011216 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 373994011217 sulfotransferase; Region: PLN02164 373994011218 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 373994011219 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 373994011220 putative ADP-ribose binding site [chemical binding]; other site 373994011221 putative active site [active] 373994011222 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 373994011223 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 373994011224 putative acyl-acceptor binding pocket; other site 373994011225 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 373994011226 catalytic motif [active] 373994011227 Catalytic residue [active] 373994011228 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 373994011229 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 373994011230 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 373994011231 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994011232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 373994011233 DNA binding residues [nucleotide binding] 373994011234 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373994011235 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 373994011236 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994011237 Probable transposase; Region: OrfB_IS605; pfam01385 373994011238 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 373994011239 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373994011240 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373994011241 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373994011242 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373994011243 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373994011244 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 373994011245 Caspase domain; Region: Peptidase_C14; pfam00656 373994011246 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994011247 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994011248 structural tetrad; other site 373994011249 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994011250 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994011251 structural tetrad; other site 373994011252 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 373994011253 Low molecular weight phosphatase family; Region: LMWPc; cd00115 373994011254 active site 373994011255 acetolactate synthase; Reviewed; Region: PRK08322 373994011256 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 373994011257 PYR/PP interface [polypeptide binding]; other site 373994011258 dimer interface [polypeptide binding]; other site 373994011259 TPP binding site [chemical binding]; other site 373994011260 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 373994011261 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 373994011262 TPP-binding site [chemical binding]; other site 373994011263 dimer interface [polypeptide binding]; other site 373994011264 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 373994011265 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 373994011266 NAD(P) binding site [chemical binding]; other site 373994011267 catalytic residues [active] 373994011268 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994011269 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 373994011270 phosphopeptide binding site; other site 373994011271 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994011272 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994011273 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 373994011274 cyclase homology domain; Region: CHD; cd07302 373994011275 nucleotidyl binding site; other site 373994011276 metal binding site [ion binding]; metal-binding site 373994011277 dimer interface [polypeptide binding]; other site 373994011278 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 373994011279 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 373994011280 GTP/Mg2+ binding site [chemical binding]; other site 373994011281 G4 box; other site 373994011282 G5 box; other site 373994011283 G1 box; other site 373994011284 Switch I region; other site 373994011285 G2 box; other site 373994011286 G3 box; other site 373994011287 Switch II region; other site 373994011288 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 373994011289 active site 373994011290 WD40 repeats; Region: WD40; smart00320 373994011291 WD40 repeats; Region: WD40; smart00320 373994011292 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994011293 structural tetrad; other site 373994011294 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994011295 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994011296 structural tetrad; other site 373994011297 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 373994011298 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 373994011299 putative active site; other site 373994011300 catalytic residue [active] 373994011301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 373994011302 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 373994011303 Predicted membrane protein [Function unknown]; Region: COG2259 373994011304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 373994011305 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 373994011306 FOG: CBS domain [General function prediction only]; Region: COG0517 373994011307 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 373994011308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011309 PAS domain; Region: PAS_9; pfam13426 373994011310 putative active site [active] 373994011311 heme pocket [chemical binding]; other site 373994011312 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994011313 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011314 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994011315 putative active site [active] 373994011316 heme pocket [chemical binding]; other site 373994011317 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011318 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994011319 putative active site [active] 373994011320 heme pocket [chemical binding]; other site 373994011321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011322 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994011323 putative active site [active] 373994011324 heme pocket [chemical binding]; other site 373994011325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011326 putative active site [active] 373994011327 heme pocket [chemical binding]; other site 373994011328 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 373994011329 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011330 putative active site [active] 373994011331 heme pocket [chemical binding]; other site 373994011332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994011333 dimer interface [polypeptide binding]; other site 373994011334 phosphorylation site [posttranslational modification] 373994011335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994011336 ATP binding site [chemical binding]; other site 373994011337 Mg2+ binding site [ion binding]; other site 373994011338 G-X-G motif; other site 373994011339 Response regulator receiver domain; Region: Response_reg; pfam00072 373994011340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994011341 active site 373994011342 phosphorylation site [posttranslational modification] 373994011343 intermolecular recognition site; other site 373994011344 dimerization interface [polypeptide binding]; other site 373994011345 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 373994011346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994011347 S-adenosylmethionine binding site [chemical binding]; other site 373994011348 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994011349 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 373994011350 putative active site pocket [active] 373994011351 dimerization interface [polypeptide binding]; other site 373994011352 putative catalytic residue [active] 373994011353 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 373994011354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994011355 S-adenosylmethionine binding site [chemical binding]; other site 373994011356 AAA domain; Region: AAA_21; pfam13304 373994011357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994011358 ABC transporter signature motif; other site 373994011359 Walker B; other site 373994011360 D-loop; other site 373994011361 H-loop/switch region; other site 373994011362 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 373994011363 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 373994011364 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994011365 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994011366 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994011367 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994011368 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 373994011369 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 373994011370 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 373994011371 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994011372 Predicted membrane protein [Function unknown]; Region: COG1808 373994011373 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 373994011374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994011375 active site 373994011376 phosphorylation site [posttranslational modification] 373994011377 intermolecular recognition site; other site 373994011378 dimerization interface [polypeptide binding]; other site 373994011379 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994011380 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994011381 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994011382 PAS domain S-box; Region: sensory_box; TIGR00229 373994011383 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011384 putative active site [active] 373994011385 heme pocket [chemical binding]; other site 373994011386 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994011387 GAF domain; Region: GAF; pfam01590 373994011388 PAS domain S-box; Region: sensory_box; TIGR00229 373994011389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011390 putative active site [active] 373994011391 heme pocket [chemical binding]; other site 373994011392 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994011393 GAF domain; Region: GAF; pfam01590 373994011394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011395 PAS fold; Region: PAS_3; pfam08447 373994011396 putative active site [active] 373994011397 heme pocket [chemical binding]; other site 373994011398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011399 PAS domain; Region: PAS_9; pfam13426 373994011400 putative active site [active] 373994011401 heme pocket [chemical binding]; other site 373994011402 PAS fold; Region: PAS_4; pfam08448 373994011403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011404 PAS domain; Region: PAS_9; pfam13426 373994011405 putative active site [active] 373994011406 heme pocket [chemical binding]; other site 373994011407 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994011408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011409 putative active site [active] 373994011410 heme pocket [chemical binding]; other site 373994011411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011412 putative active site [active] 373994011413 heme pocket [chemical binding]; other site 373994011414 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994011415 GAF domain; Region: GAF; pfam01590 373994011416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994011417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994011418 dimer interface [polypeptide binding]; other site 373994011419 phosphorylation site [posttranslational modification] 373994011420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994011421 ATP binding site [chemical binding]; other site 373994011422 Mg2+ binding site [ion binding]; other site 373994011423 G-X-G motif; other site 373994011424 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994011425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994011426 active site 373994011427 phosphorylation site [posttranslational modification] 373994011428 intermolecular recognition site; other site 373994011429 dimerization interface [polypeptide binding]; other site 373994011430 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 373994011431 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 373994011432 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 373994011433 Predicted membrane protein [Function unknown]; Region: COG4325 373994011434 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 373994011435 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373994011436 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994011437 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 373994011438 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 373994011439 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 373994011440 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373994011441 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373994011442 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373994011443 short chain dehydrogenase; Provisional; Region: PRK06701 373994011444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994011445 NAD(P) binding site [chemical binding]; other site 373994011446 active site 373994011447 ChaB; Region: ChaB; pfam06150 373994011448 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 373994011449 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 373994011450 dimerization interface [polypeptide binding]; other site 373994011451 DPS ferroxidase diiron center [ion binding]; other site 373994011452 ion pore; other site 373994011453 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 373994011454 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 373994011455 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994011456 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994011457 active site 373994011458 ATP binding site [chemical binding]; other site 373994011459 substrate binding site [chemical binding]; other site 373994011460 activation loop (A-loop); other site 373994011461 cell division protein FtsN; Provisional; Region: PRK12757 373994011462 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994011463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994011464 binding surface 373994011465 TPR repeat; Region: TPR_11; pfam13414 373994011466 TPR motif; other site 373994011467 TPR repeat; Region: TPR_11; pfam13414 373994011468 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994011469 TPR repeat; Region: TPR_11; pfam13414 373994011470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994011471 TPR motif; other site 373994011472 binding surface 373994011473 TPR repeat; Region: TPR_11; pfam13414 373994011474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994011475 binding surface 373994011476 TPR motif; other site 373994011477 TPR repeat; Region: TPR_11; pfam13414 373994011478 TPR repeat; Region: TPR_11; pfam13414 373994011479 TPR repeat; Region: TPR_11; pfam13414 373994011480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994011481 TPR motif; other site 373994011482 binding surface 373994011483 TPR repeat; Region: TPR_11; pfam13414 373994011484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994011485 TPR motif; other site 373994011486 binding surface 373994011487 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994011488 Circadian oscillating protein COP23; Region: COP23; pfam14218 373994011489 proton extrusion protein PcxA; Provisional; Region: PRK02507 373994011490 acylphosphatase; Provisional; Region: PRK14423 373994011491 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 373994011492 Major royal jelly protein; Region: MRJP; pfam03022 373994011493 isoleucyl-tRNA synthetase; Region: PLN02843 373994011494 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 373994011495 active site 373994011496 HIGH motif; other site 373994011497 nucleotide binding site [chemical binding]; other site 373994011498 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 373994011499 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 373994011500 active site 373994011501 KMSKS motif; other site 373994011502 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 373994011503 tRNA binding surface [nucleotide binding]; other site 373994011504 anticodon binding site; other site 373994011505 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 373994011506 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 373994011507 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 373994011508 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 373994011509 putative active site [active] 373994011510 putative NTP binding site [chemical binding]; other site 373994011511 putative nucleic acid binding site [nucleotide binding]; other site 373994011512 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 373994011513 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 373994011514 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 373994011515 active site 373994011516 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 373994011517 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 373994011518 dimer interface [polypeptide binding]; other site 373994011519 active site 373994011520 heme binding site [chemical binding]; other site 373994011521 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 373994011522 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 373994011523 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 373994011524 P-loop; other site 373994011525 Magnesium ion binding site [ion binding]; other site 373994011526 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 373994011527 Magnesium ion binding site [ion binding]; other site 373994011528 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 373994011529 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 373994011530 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 373994011531 catalytic site [active] 373994011532 putative active site [active] 373994011533 putative substrate binding site [chemical binding]; other site 373994011534 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 373994011535 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 373994011536 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 373994011537 AAA ATPase domain; Region: AAA_16; pfam13191 373994011538 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994011539 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 373994011540 active site 373994011541 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 373994011542 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994011543 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 373994011544 S-layer homology domain; Region: SLH; pfam00395 373994011545 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 373994011546 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 373994011547 threonine synthase; Reviewed; Region: PRK06721 373994011548 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 373994011549 homodimer interface [polypeptide binding]; other site 373994011550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994011551 catalytic residue [active] 373994011552 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 373994011553 Glycoprotease family; Region: Peptidase_M22; pfam00814 373994011554 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 373994011555 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 373994011556 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 373994011557 active site 373994011558 NTP binding site [chemical binding]; other site 373994011559 metal binding triad [ion binding]; metal-binding site 373994011560 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 373994011561 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 373994011562 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 373994011563 2TM domain; Region: 2TM; pfam13239 373994011564 WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998 373994011565 HEAT repeats; Region: HEAT_2; pfam13646 373994011566 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 373994011567 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 373994011568 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 373994011569 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 373994011570 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 373994011571 glutamine binding [chemical binding]; other site 373994011572 catalytic triad [active] 373994011573 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 373994011574 metal-binding heat shock protein; Provisional; Region: PRK00016 373994011575 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 373994011576 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 373994011577 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 373994011578 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 373994011579 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373994011580 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373994011581 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 373994011582 phosphoglucomutase; Region: PLN02307 373994011583 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 373994011584 substrate binding site [chemical binding]; other site 373994011585 dimer interface [polypeptide binding]; other site 373994011586 active site 373994011587 metal binding site [ion binding]; metal-binding site 373994011588 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 373994011589 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 373994011590 FMN binding site [chemical binding]; other site 373994011591 active site 373994011592 catalytic residues [active] 373994011593 substrate binding site [chemical binding]; other site 373994011594 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994011595 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994011596 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994011597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 373994011598 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994011599 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994011600 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994011601 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994011602 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 373994011603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994011604 Walker A motif; other site 373994011605 ATP binding site [chemical binding]; other site 373994011606 Walker B motif; other site 373994011607 arginine finger; other site 373994011608 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 373994011609 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 373994011610 metal ion-dependent adhesion site (MIDAS); other site 373994011611 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 373994011612 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 373994011613 dimerization interface [polypeptide binding]; other site 373994011614 active site 373994011615 metal binding site [ion binding]; metal-binding site 373994011616 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 373994011617 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 373994011618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994011619 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994011620 dimer interface [polypeptide binding]; other site 373994011621 phosphorylation site [posttranslational modification] 373994011622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994011623 ATP binding site [chemical binding]; other site 373994011624 Mg2+ binding site [ion binding]; other site 373994011625 G-X-G motif; other site 373994011626 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 373994011627 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 373994011628 ligand binding site [chemical binding]; other site 373994011629 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 373994011630 Rab subfamily motif 1 (RabSF1); other site 373994011631 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 373994011632 G1 box; other site 373994011633 GTP/Mg2+ binding site [chemical binding]; other site 373994011634 Rab subfamily motif 2 (RabSF2); other site 373994011635 Switch I region; other site 373994011636 G2 box; other site 373994011637 effector interaction site; other site 373994011638 GDI interaction site; other site 373994011639 Rab family motif 1 (RabF1); other site 373994011640 GEF interaction site [polypeptide binding]; other site 373994011641 Rab family motif 2 (RabF2); other site 373994011642 G3 box; other site 373994011643 Switch II region; other site 373994011644 Rab family motif 3 (RabF3); other site 373994011645 Rab family motif 4 (RabF4); other site 373994011646 Rab family motif 5 (RabF5); other site 373994011647 Rab subfamily motif 3 (RabSF3); other site 373994011648 G4 box; other site 373994011649 G5 box; other site 373994011650 Rab subfamily motif 4 (RabSF4); other site 373994011651 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994011652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994011653 ATP binding site [chemical binding]; other site 373994011654 Mg2+ binding site [ion binding]; other site 373994011655 G-X-G motif; other site 373994011656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994011657 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373994011658 putative substrate translocation pore; other site 373994011659 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 373994011660 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 373994011661 active site 373994011662 Zn binding site [ion binding]; other site 373994011663 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 373994011664 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994011665 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 373994011666 dimerization interface [polypeptide binding]; other site 373994011667 substrate binding pocket [chemical binding]; other site 373994011668 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 373994011669 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 373994011670 Putative Catalytic site; other site 373994011671 DXD motif; other site 373994011672 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 373994011673 NlpC/P60 family; Region: NLPC_P60; pfam00877 373994011674 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 373994011675 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 373994011676 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 373994011677 FMN binding site [chemical binding]; other site 373994011678 active site 373994011679 substrate binding site [chemical binding]; other site 373994011680 catalytic residue [active] 373994011681 hypothetical protein; Provisional; Region: PRK07236 373994011682 hypothetical protein; Provisional; Region: PRK06753 373994011683 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 373994011684 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 373994011685 catalytic residues [active] 373994011686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373994011687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994011688 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 373994011689 putative effector binding pocket; other site 373994011690 dimerization interface [polypeptide binding]; other site 373994011691 CAAX protease self-immunity; Region: Abi; pfam02517 373994011692 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 373994011693 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373994011694 Chain length determinant protein; Region: Wzz; pfam02706 373994011695 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 373994011696 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 373994011697 O-Antigen ligase; Region: Wzy_C; pfam04932 373994011698 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994011699 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 373994011700 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994011701 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 373994011702 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 373994011703 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 373994011704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 373994011705 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 373994011706 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 373994011707 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 373994011708 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 373994011709 active site lid residues [active] 373994011710 substrate binding pocket [chemical binding]; other site 373994011711 catalytic residues [active] 373994011712 substrate-Mg2+ binding site; other site 373994011713 aspartate-rich region 1; other site 373994011714 aspartate-rich region 2; other site 373994011715 phytoene desaturase; Region: phytoene_desat; TIGR02731 373994011716 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994011717 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 373994011718 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 373994011719 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 373994011720 Mg++ binding site [ion binding]; other site 373994011721 putative catalytic motif [active] 373994011722 substrate binding site [chemical binding]; other site 373994011723 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 373994011724 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 373994011725 dimer interface [polypeptide binding]; other site 373994011726 active site 373994011727 glycine-pyridoxal phosphate binding site [chemical binding]; other site 373994011728 folate binding site [chemical binding]; other site 373994011729 chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994 373994011730 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 373994011731 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 373994011732 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 373994011733 DNA damage checkpoint protein; Region: LCD1; pfam09798 373994011734 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 373994011735 anti sigma factor interaction site; other site 373994011736 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 373994011737 regulatory phosphorylation site [posttranslational modification]; other site 373994011738 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 373994011739 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 373994011740 argininosuccinate synthase; Provisional; Region: PRK13820 373994011741 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 373994011742 ANP binding site [chemical binding]; other site 373994011743 Substrate Binding Site II [chemical binding]; other site 373994011744 Substrate Binding Site I [chemical binding]; other site 373994011745 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 373994011746 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994011747 active site 373994011748 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994011749 GAF domain; Region: GAF; pfam01590 373994011750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994011751 dimer interface [polypeptide binding]; other site 373994011752 phosphorylation site [posttranslational modification] 373994011753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994011754 ATP binding site [chemical binding]; other site 373994011755 Mg2+ binding site [ion binding]; other site 373994011756 G-X-G motif; other site 373994011757 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 373994011758 rRNA interaction site [nucleotide binding]; other site 373994011759 S8 interaction site; other site 373994011760 putative laminin-1 binding site; other site 373994011761 elongation factor Ts; Provisional; Region: tsf; PRK09377 373994011762 UBA/TS-N domain; Region: UBA; pfam00627 373994011763 Elongation factor TS; Region: EF_TS; pfam00889 373994011764 Elongation factor TS; Region: EF_TS; pfam00889 373994011765 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 373994011766 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 373994011767 generic binding surface II; other site 373994011768 ssDNA binding site; other site 373994011769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994011770 ATP binding site [chemical binding]; other site 373994011771 putative Mg++ binding site [ion binding]; other site 373994011772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994011773 nucleotide binding region [chemical binding]; other site 373994011774 ATP-binding site [chemical binding]; other site 373994011775 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 373994011776 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 373994011777 GMP synthase; Reviewed; Region: guaA; PRK00074 373994011778 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 373994011779 AMP/PPi binding site [chemical binding]; other site 373994011780 candidate oxyanion hole; other site 373994011781 catalytic triad [active] 373994011782 potential glutamine specificity residues [chemical binding]; other site 373994011783 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 373994011784 ATP Binding subdomain [chemical binding]; other site 373994011785 Ligand Binding sites [chemical binding]; other site 373994011786 Dimerization subdomain; other site 373994011787 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 373994011788 CP12 domain; Region: CP12; pfam02672 373994011789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 373994011790 FIST N domain; Region: FIST; smart00897 373994011791 FIST C domain; Region: FIST_C; pfam10442 373994011792 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 373994011793 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994011794 active site 373994011795 metal binding site [ion binding]; metal-binding site 373994011796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994011797 S-adenosylmethionine binding site [chemical binding]; other site 373994011798 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 373994011799 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373994011800 active site 373994011801 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 373994011802 hypothetical protein; Validated; Region: PRK07198 373994011803 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 373994011804 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 373994011805 dimerization interface [polypeptide binding]; other site 373994011806 active site 373994011807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994011808 binding surface 373994011809 TPR motif; other site 373994011810 TPR repeat; Region: TPR_11; pfam13414 373994011811 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 373994011812 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373994011813 substrate binding pocket [chemical binding]; other site 373994011814 membrane-bound complex binding site; other site 373994011815 magnesium chelatase subunit H; Provisional; Region: PLN03241 373994011816 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 373994011817 von Willebrand factor type D domain; Region: VWD; cl02516 373994011818 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 373994011819 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373994011820 active site 373994011821 metal binding site [ion binding]; metal-binding site 373994011822 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 373994011823 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994011824 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994011825 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994011826 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994011827 active site 373994011828 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994011829 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994011830 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 373994011831 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994011832 active site 373994011833 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994011834 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994011835 active site 373994011836 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994011837 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 373994011838 active site 373994011839 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 373994011840 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994011841 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 373994011842 Walker A/P-loop; other site 373994011843 ATP binding site [chemical binding]; other site 373994011844 Q-loop/lid; other site 373994011845 ABC transporter signature motif; other site 373994011846 Walker B; other site 373994011847 D-loop; other site 373994011848 H-loop/switch region; other site 373994011849 Bacterial sugar transferase; Region: Bac_transf; cl00939 373994011850 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373994011851 Chain length determinant protein; Region: Wzz; cl15801 373994011852 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 373994011853 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994011854 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 373994011855 putative ADP-binding pocket [chemical binding]; other site 373994011856 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 373994011857 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994011858 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373994011859 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 373994011860 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 373994011861 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 373994011862 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 373994011863 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 373994011864 extended (e) SDRs; Region: SDR_e; cd08946 373994011865 NAD(P) binding site [chemical binding]; other site 373994011866 active site 373994011867 substrate binding site [chemical binding]; other site 373994011868 Predicted dehydrogenase [General function prediction only]; Region: COG0579 373994011869 hydroxyglutarate oxidase; Provisional; Region: PRK11728 373994011870 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 373994011871 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 373994011872 substrate binding site; other site 373994011873 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 373994011874 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994011875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994011876 binding surface 373994011877 TPR repeat; Region: TPR_11; pfam13414 373994011878 TPR motif; other site 373994011879 TPR repeat; Region: TPR_11; pfam13414 373994011880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994011881 binding surface 373994011882 TPR motif; other site 373994011883 TPR repeat; Region: TPR_11; pfam13414 373994011884 TPR repeat; Region: TPR_11; pfam13414 373994011885 Protein phosphatase 2C; Region: PP2C_2; pfam13672 373994011886 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 373994011887 metal ion-dependent adhesion site (MIDAS); other site 373994011888 Response regulator receiver domain; Region: Response_reg; pfam00072 373994011889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994011890 active site 373994011891 phosphorylation site [posttranslational modification] 373994011892 intermolecular recognition site; other site 373994011893 dimerization interface [polypeptide binding]; other site 373994011894 Response regulator receiver domain; Region: Response_reg; pfam00072 373994011895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994011896 active site 373994011897 phosphorylation site [posttranslational modification] 373994011898 intermolecular recognition site; other site 373994011899 dimerization interface [polypeptide binding]; other site 373994011900 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 373994011901 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 373994011902 putative tRNA-binding site [nucleotide binding]; other site 373994011903 B3/4 domain; Region: B3_4; pfam03483 373994011904 tRNA synthetase B5 domain; Region: B5; smart00874 373994011905 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 373994011906 dimer interface [polypeptide binding]; other site 373994011907 motif 1; other site 373994011908 motif 3; other site 373994011909 motif 2; other site 373994011910 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 373994011911 YciI-like protein; Reviewed; Region: PRK12864 373994011912 XisI protein; Region: XisI; pfam08869 373994011913 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 373994011914 NTPase; Region: NTPase_1; cl17478 373994011915 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 373994011916 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994011917 metal binding site [ion binding]; metal-binding site 373994011918 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 373994011919 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994011920 nickel responsive regulator; Provisional; Region: PRK02967 373994011921 PemK-like protein; Region: PemK; pfam02452 373994011922 AAA ATPase domain; Region: AAA_16; pfam13191 373994011923 AAA domain; Region: AAA_22; pfam13401 373994011924 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 373994011925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994011926 dimer interface [polypeptide binding]; other site 373994011927 conserved gate region; other site 373994011928 putative PBP binding loops; other site 373994011929 ABC-ATPase subunit interface; other site 373994011930 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 373994011931 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 373994011932 photosystem II 47 kDa protein; Region: psbB; CHL00062 373994011933 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 373994011934 30S ribosomal protein S1; Reviewed; Region: PRK07400 373994011935 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 373994011936 RNA binding site [nucleotide binding]; other site 373994011937 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 373994011938 RNA binding site [nucleotide binding]; other site 373994011939 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 373994011940 RNA binding site [nucleotide binding]; other site 373994011941 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 373994011942 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 373994011943 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 373994011944 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 373994011945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994011946 motif II; other site 373994011947 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 373994011948 heme binding pocket [chemical binding]; other site 373994011949 heme ligand [chemical binding]; other site 373994011950 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 373994011951 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 373994011952 active site 373994011953 substrate binding site [chemical binding]; other site 373994011954 metal binding site [ion binding]; metal-binding site 373994011955 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 373994011956 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994011957 active site 373994011958 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994011959 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994011960 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 373994011961 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994011962 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 373994011963 putative ADP-binding pocket [chemical binding]; other site 373994011964 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 373994011965 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 373994011966 dimer interface [polypeptide binding]; other site 373994011967 decamer (pentamer of dimers) interface [polypeptide binding]; other site 373994011968 catalytic triad [active] 373994011969 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994011970 putative active site [active] 373994011971 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 373994011972 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994011973 Phytochrome region; Region: PHY; pfam00360 373994011974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994011975 dimer interface [polypeptide binding]; other site 373994011976 phosphorylation site [posttranslational modification] 373994011977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994011978 ATP binding site [chemical binding]; other site 373994011979 Mg2+ binding site [ion binding]; other site 373994011980 G-X-G motif; other site 373994011981 Response regulator receiver domain; Region: Response_reg; pfam00072 373994011982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994011983 active site 373994011984 phosphorylation site [posttranslational modification] 373994011985 intermolecular recognition site; other site 373994011986 dimerization interface [polypeptide binding]; other site 373994011987 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994011988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994011989 active site 373994011990 phosphorylation site [posttranslational modification] 373994011991 intermolecular recognition site; other site 373994011992 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994011993 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011994 putative active site [active] 373994011995 heme pocket [chemical binding]; other site 373994011996 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994011997 putative active site [active] 373994011998 heme pocket [chemical binding]; other site 373994011999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994012000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994012001 dimer interface [polypeptide binding]; other site 373994012002 phosphorylation site [posttranslational modification] 373994012003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994012004 ATP binding site [chemical binding]; other site 373994012005 Mg2+ binding site [ion binding]; other site 373994012006 G-X-G motif; other site 373994012007 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 373994012008 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373994012009 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373994012010 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 373994012011 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 373994012012 active site 373994012013 Zn binding site [ion binding]; other site 373994012014 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 373994012015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994012016 S-adenosylmethionine binding site [chemical binding]; other site 373994012017 PAS fold; Region: PAS_4; pfam08448 373994012018 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994012019 putative active site [active] 373994012020 heme pocket [chemical binding]; other site 373994012021 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994012022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994012023 putative active site [active] 373994012024 heme pocket [chemical binding]; other site 373994012025 PAS domain; Region: PAS_8; pfam13188 373994012026 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994012027 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994012028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994012029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994012030 dimer interface [polypeptide binding]; other site 373994012031 phosphorylation site [posttranslational modification] 373994012032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994012033 ATP binding site [chemical binding]; other site 373994012034 Mg2+ binding site [ion binding]; other site 373994012035 G-X-G motif; other site 373994012036 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994012037 Ligand Binding Site [chemical binding]; other site 373994012038 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994012039 Ligand Binding Site [chemical binding]; other site 373994012040 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 373994012041 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 373994012042 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994012043 catalytic loop [active] 373994012044 iron binding site [ion binding]; other site 373994012045 photosystem II protein K; Region: psbK; CHL00047 373994012046 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994012047 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994012048 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994012049 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 373994012050 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 373994012051 cobalamin synthase; Reviewed; Region: cobS; PRK00235 373994012052 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 373994012053 comF family protein; Region: comF; TIGR00201 373994012054 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373994012055 active site 373994012056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994012057 Coenzyme A binding pocket [chemical binding]; other site 373994012058 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 373994012059 active site 373994012060 dinuclear metal binding site [ion binding]; other site 373994012061 dimerization interface [polypeptide binding]; other site 373994012062 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 373994012063 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 373994012064 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 373994012065 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 373994012066 classical (c) SDRs; Region: SDR_c; cd05233 373994012067 NAD(P) binding site [chemical binding]; other site 373994012068 active site 373994012069 ParB-like nuclease domain; Region: ParBc; cl02129 373994012070 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 373994012071 Stage II sporulation protein; Region: SpoIID; pfam08486 373994012072 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 373994012073 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994012074 catalytic loop [active] 373994012075 iron binding site [ion binding]; other site 373994012076 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 373994012077 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 373994012078 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 373994012079 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994012080 catalytic loop [active] 373994012081 iron binding site [ion binding]; other site 373994012082 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 373994012083 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 373994012084 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 373994012085 Uncharacterized conserved protein [Function unknown]; Region: COG3937 373994012086 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 373994012087 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 373994012088 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 373994012089 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 373994012090 Walker A motif; other site 373994012091 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 373994012092 protein-splicing catalytic site; other site 373994012093 thioester formation/cholesterol transfer; other site 373994012094 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 373994012095 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 373994012096 protein-splicing catalytic site; other site 373994012097 replicative DNA helicase; Region: DnaB; TIGR00665 373994012098 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 373994012099 ATP binding site [chemical binding]; other site 373994012100 Walker B motif; other site 373994012101 DNA binding loops [nucleotide binding] 373994012102 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 373994012103 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 373994012104 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 373994012105 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 373994012106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994012107 FeS/SAM binding site; other site 373994012108 Psb28 protein; Region: Psb28; pfam03912 373994012109 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 373994012110 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 373994012111 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 373994012112 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 373994012113 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994012114 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 373994012115 active site 373994012116 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 373994012117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 373994012118 ATP binding site [chemical binding]; other site 373994012119 putative Mg++ binding site [ion binding]; other site 373994012120 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 373994012121 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 373994012122 Dihaem cytochrome c; Region: DHC; pfam09626 373994012123 Uncharacterized conserved protein [Function unknown]; Region: COG0432 373994012124 Uncharacterized conserved protein [Function unknown]; Region: COG0327 373994012125 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 373994012126 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 373994012127 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 373994012128 Beta-Casp domain; Region: Beta-Casp; cl12567 373994012129 NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180 373994012130 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 373994012131 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 373994012132 P-loop; other site 373994012133 Magnesium ion binding site [ion binding]; other site 373994012134 Sporulation and spore germination; Region: Germane; cl11253 373994012135 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 373994012136 active site 373994012137 catalytic residues [active] 373994012138 DNA binding site [nucleotide binding] 373994012139 Int/Topo IB signature motif; other site 373994012140 TSC-22/dip/bun family; Region: TSC22; pfam01166 373994012141 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 373994012142 PAS domain S-box; Region: sensory_box; TIGR00229 373994012143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994012144 putative active site [active] 373994012145 heme pocket [chemical binding]; other site 373994012146 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994012147 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994012148 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994012149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994012150 putative active site [active] 373994012151 heme pocket [chemical binding]; other site 373994012152 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 373994012153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994012154 putative active site [active] 373994012155 heme pocket [chemical binding]; other site 373994012156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994012157 putative active site [active] 373994012158 heme pocket [chemical binding]; other site 373994012159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994012160 dimer interface [polypeptide binding]; other site 373994012161 phosphorylation site [posttranslational modification] 373994012162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994012163 ATP binding site [chemical binding]; other site 373994012164 Mg2+ binding site [ion binding]; other site 373994012165 G-X-G motif; other site 373994012166 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 373994012167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994012168 S-adenosylmethionine binding site [chemical binding]; other site 373994012169 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 373994012170 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 373994012171 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 373994012172 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 373994012173 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 373994012174 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 373994012175 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994012176 Helix-turn-helix domain; Region: HTH_17; cl17695 373994012177 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 373994012178 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 373994012179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994012180 Walker A motif; other site 373994012181 ATP binding site [chemical binding]; other site 373994012182 Walker B motif; other site 373994012183 arginine finger; other site 373994012184 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 373994012185 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 373994012186 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 373994012187 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 373994012188 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 373994012189 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 373994012190 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 373994012191 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 373994012192 Ycf39; Provisional; Region: ycf39; CHL00194 373994012193 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 373994012194 NAD(P) binding site [chemical binding]; other site 373994012195 putative active site [active] 373994012196 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 373994012197 ATP-NAD kinase; Region: NAD_kinase; pfam01513 373994012198 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994012199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994012200 active site 373994012201 phosphorylation site [posttranslational modification] 373994012202 intermolecular recognition site; other site 373994012203 dimerization interface [polypeptide binding]; other site 373994012204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994012205 DNA binding site [nucleotide binding] 373994012206 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 373994012207 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 373994012208 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 373994012209 active site 373994012210 ribulose/triose binding site [chemical binding]; other site 373994012211 phosphate binding site [ion binding]; other site 373994012212 substrate (anthranilate) binding pocket [chemical binding]; other site 373994012213 product (indole) binding pocket [chemical binding]; other site 373994012214 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 373994012215 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994012216 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 373994012217 Caspase domain; Region: Peptidase_C14; pfam00656 373994012218 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373994012219 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 373994012220 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994012221 catalytic loop [active] 373994012222 iron binding site [ion binding]; other site 373994012223 Staphylococcal nuclease homologues; Region: SNc; smart00318 373994012224 Catalytic site; other site 373994012225 Staphylococcal nuclease homologue; Region: SNase; pfam00565 373994012226 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 373994012227 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 373994012228 active site 373994012229 dimerization interface [polypeptide binding]; other site 373994012230 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 373994012231 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 373994012232 active site 373994012233 substrate binding site [chemical binding]; other site 373994012234 Mg2+ binding site [ion binding]; other site 373994012235 Lamin Tail Domain; Region: LTD; pfam00932 373994012236 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 373994012237 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373994012238 HSP70 interaction site [polypeptide binding]; other site 373994012239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994012240 binding surface 373994012241 TPR motif; other site 373994012242 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 373994012243 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 373994012244 dimer interface [polypeptide binding]; other site 373994012245 motif 1; other site 373994012246 active site 373994012247 motif 2; other site 373994012248 motif 3; other site 373994012249 Ferredoxin [Energy production and conversion]; Region: COG1146 373994012250 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 373994012251 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 373994012252 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 373994012253 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 373994012254 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994012255 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994012256 active site 373994012257 ATP binding site [chemical binding]; other site 373994012258 substrate binding site [chemical binding]; other site 373994012259 activation loop (A-loop); other site 373994012260 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994012261 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 373994012262 putative metal binding site; other site 373994012263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994012264 binding surface 373994012265 TPR motif; other site 373994012266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994012267 binding surface 373994012268 TPR repeat; Region: TPR_11; pfam13414 373994012269 TPR motif; other site 373994012270 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373994012271 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 373994012272 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 373994012273 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 373994012274 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 373994012275 FAD binding pocket [chemical binding]; other site 373994012276 FAD binding motif [chemical binding]; other site 373994012277 phosphate binding motif [ion binding]; other site 373994012278 beta-alpha-beta structure motif; other site 373994012279 NAD(p) ribose binding residues [chemical binding]; other site 373994012280 NAD binding pocket [chemical binding]; other site 373994012281 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 373994012282 aspartate aminotransferase; Provisional; Region: PRK05764 373994012283 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373994012284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994012285 homodimer interface [polypeptide binding]; other site 373994012286 catalytic residue [active] 373994012287 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994012288 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994012289 active site 373994012290 ATP binding site [chemical binding]; other site 373994012291 substrate binding site [chemical binding]; other site 373994012292 activation loop (A-loop); other site 373994012293 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 373994012294 Aluminium resistance protein; Region: Alum_res; pfam06838 373994012295 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 373994012296 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 373994012297 Fatty acid desaturase; Region: FA_desaturase; pfam00487 373994012298 Di-iron ligands [ion binding]; other site 373994012299 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 373994012300 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 373994012301 putative di-iron ligands [ion binding]; other site 373994012302 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 373994012303 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 373994012304 putative di-iron ligands [ion binding]; other site 373994012305 Fatty acid desaturase; Region: FA_desaturase; pfam00487 373994012306 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 373994012307 putative di-iron ligands [ion binding]; other site 373994012308 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 373994012309 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 373994012310 putative catalytic cysteine [active] 373994012311 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 373994012312 homopentamer interface [polypeptide binding]; other site 373994012313 active site 373994012314 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 373994012315 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994012316 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373994012317 glucose-1-dehydrogenase; Provisional; Region: PRK08936 373994012318 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 373994012319 NAD binding site [chemical binding]; other site 373994012320 homodimer interface [polypeptide binding]; other site 373994012321 active site 373994012322 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 373994012323 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 373994012324 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373994012325 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 373994012326 aromatic amino acid transport protein; Region: araaP; TIGR00837 373994012327 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 373994012328 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 373994012329 trimer interface [polypeptide binding]; other site 373994012330 active site 373994012331 substrate binding site [chemical binding]; other site 373994012332 CoA binding site [chemical binding]; other site 373994012333 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 373994012334 Glutaminase; Region: Glutaminase; cl00907 373994012335 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 373994012336 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 373994012337 FAD binding pocket [chemical binding]; other site 373994012338 FAD binding motif [chemical binding]; other site 373994012339 phosphate binding motif [ion binding]; other site 373994012340 beta-alpha-beta structure motif; other site 373994012341 NAD binding pocket [chemical binding]; other site 373994012342 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994012343 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 373994012344 catalytic loop [active] 373994012345 iron binding site [ion binding]; other site 373994012346 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 373994012347 EamA-like transporter family; Region: EamA; pfam00892 373994012348 EamA-like transporter family; Region: EamA; pfam00892 373994012349 AAA domain; Region: AAA_17; pfam13207 373994012350 NACHT domain; Region: NACHT; pfam05729 373994012351 ferrochelatase; Reviewed; Region: hemH; PRK00035 373994012352 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 373994012353 active site 373994012354 C-terminal domain interface [polypeptide binding]; other site 373994012355 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 373994012356 active site 373994012357 N-terminal domain interface [polypeptide binding]; other site 373994012358 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 373994012359 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 373994012360 Cytochrome P450; Region: p450; cl12078 373994012361 adenylosuccinate lyase; Provisional; Region: PRK07380 373994012362 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 373994012363 tetramer interface [polypeptide binding]; other site 373994012364 active site 373994012365 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 373994012366 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 373994012367 MutS domain I; Region: MutS_I; pfam01624 373994012368 MutS domain II; Region: MutS_II; pfam05188 373994012369 MutS domain III; Region: MutS_III; pfam05192 373994012370 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 373994012371 Walker A/P-loop; other site 373994012372 ATP binding site [chemical binding]; other site 373994012373 Q-loop/lid; other site 373994012374 ABC transporter signature motif; other site 373994012375 Walker B; other site 373994012376 D-loop; other site 373994012377 H-loop/switch region; other site 373994012378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994012379 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994012380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994012381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994012382 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994012383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994012384 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 373994012385 NADH(P)-binding; Region: NAD_binding_10; pfam13460 373994012386 NAD binding site [chemical binding]; other site 373994012387 substrate binding site [chemical binding]; other site 373994012388 putative active site [active] 373994012389 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 373994012390 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 373994012391 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 373994012392 metal ion-dependent adhesion site (MIDAS); other site 373994012393 Cna protein B-type domain; Region: Cna_B; pfam05738 373994012394 RHS Repeat; Region: RHS_repeat; cl11982 373994012395 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 373994012396 RHS Repeat; Region: RHS_repeat; pfam05593 373994012397 RHS Repeat; Region: RHS_repeat; pfam05593 373994012398 RHS Repeat; Region: RHS_repeat; pfam05593 373994012399 RHS Repeat; Region: RHS_repeat; pfam05593 373994012400 RHS Repeat; Region: RHS_repeat; pfam05593 373994012401 RHS Repeat; Region: RHS_repeat; pfam05593 373994012402 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 373994012403 RHS Repeat; Region: RHS_repeat; pfam05593 373994012404 RHS Repeat; Region: RHS_repeat; pfam05593 373994012405 RHS Repeat; Region: RHS_repeat; pfam05593 373994012406 RHS Repeat; Region: RHS_repeat; pfam05593 373994012407 RHS Repeat; Region: RHS_repeat; cl11982 373994012408 RHS Repeat; Region: RHS_repeat; pfam05593 373994012409 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 373994012410 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 373994012411 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 373994012412 substrate binding site [chemical binding]; other site 373994012413 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 373994012414 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 373994012415 substrate binding site [chemical binding]; other site 373994012416 ligand binding site [chemical binding]; other site 373994012417 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 373994012418 30S subunit binding site; other site 373994012419 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994012420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994012421 S-adenosylmethionine binding site [chemical binding]; other site 373994012422 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 373994012423 putative metal binding site [ion binding]; other site 373994012424 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 373994012425 active site 373994012426 catalytic triad [active] 373994012427 oxyanion hole [active] 373994012428 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 373994012429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994012430 binding surface 373994012431 TPR repeat; Region: TPR_11; pfam13414 373994012432 TPR motif; other site 373994012433 TPR repeat; Region: TPR_11; pfam13414 373994012434 TPR repeat; Region: TPR_11; pfam13414 373994012435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994012436 binding surface 373994012437 TPR motif; other site 373994012438 TPR repeat; Region: TPR_11; pfam13414 373994012439 TPR repeat; Region: TPR_11; pfam13414 373994012440 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 373994012441 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994012442 FeS/SAM binding site; other site 373994012443 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 373994012444 PEP-CTERM family integral membrane protein; Region: PEP_integral; TIGR02921 373994012445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994012446 phosphoserine phosphatase SerB; Region: serB; TIGR00338 373994012447 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994012448 motif II; other site 373994012449 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373994012450 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373994012451 NB-ARC domain; Region: NB-ARC; pfam00931 373994012452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994012453 TPR motif; other site 373994012454 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994012455 binding surface 373994012456 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994012457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994012458 binding surface 373994012459 TPR motif; other site 373994012460 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994012461 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994012462 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994012463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994012464 binding surface 373994012465 TPR motif; other site 373994012466 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994012467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994012468 binding surface 373994012469 TPR motif; other site 373994012470 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994012471 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994012472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994012473 binding surface 373994012474 TPR motif; other site 373994012475 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 373994012476 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 373994012477 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 373994012478 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); Region: PCMT; pfam01135 373994012479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994012480 S-adenosylmethionine binding site [chemical binding]; other site 373994012481 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 373994012482 active site 373994012483 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 373994012484 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 373994012485 Uncharacterized conserved protein [Function unknown]; Region: COG1262 373994012486 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 373994012487 AAA domain; Region: AAA_11; pfam13086 373994012488 Part of AAA domain; Region: AAA_19; pfam13245 373994012489 Uncharacterized conserved protein (DUF2315); Region: DUF2315; pfam10231 373994012490 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 373994012491 AAA domain; Region: AAA_12; pfam13087 373994012492 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 373994012493 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 373994012494 PLD-like domain; Region: PLDc_2; pfam13091 373994012495 putative active site [active] 373994012496 catalytic site [active] 373994012497 Nuclease-related domain; Region: NERD; pfam08378 373994012498 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994012499 putative active site [active] 373994012500 CAAX protease self-immunity; Region: Abi; pfam02517 373994012501 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 373994012502 active site 373994012503 hydrophilic channel; other site 373994012504 dimerization interface [polypeptide binding]; other site 373994012505 catalytic residues [active] 373994012506 active site lid [active] 373994012507 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 373994012508 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 373994012509 Divergent PAP2 family; Region: DUF212; pfam02681 373994012510 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 373994012511 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 373994012512 substrate binding pocket [chemical binding]; other site 373994012513 chain length determination region; other site 373994012514 substrate-Mg2+ binding site; other site 373994012515 catalytic residues [active] 373994012516 aspartate-rich region 1; other site 373994012517 active site lid residues [active] 373994012518 aspartate-rich region 2; other site 373994012519 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 373994012520 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 373994012521 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 373994012522 homodimer interface [polypeptide binding]; other site 373994012523 NADP binding site [chemical binding]; other site 373994012524 substrate binding site [chemical binding]; other site 373994012525 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 373994012526 nudix motif; other site 373994012527 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 373994012528 Domain of unknown function DUF20; Region: UPF0118; pfam01594 373994012529 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 373994012530 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994012531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994012532 S-adenosylmethionine binding site [chemical binding]; other site 373994012533 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994012534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994012535 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994012536 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994012537 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 373994012538 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 373994012539 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 373994012540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994012541 Coenzyme A binding pocket [chemical binding]; other site 373994012542 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994012543 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 373994012544 homotrimer interaction site [polypeptide binding]; other site 373994012545 putative active site [active] 373994012546 aspartoacylase; Provisional; Region: PRK02259 373994012547 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 373994012548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994012549 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373994012550 putative substrate translocation pore; other site 373994012551 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994012552 MAPEG family; Region: MAPEG; cl09190 373994012553 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994012554 DNA binding residues [nucleotide binding] 373994012555 dimerization interface [polypeptide binding]; other site 373994012556 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994012557 Cytochrome P450; Region: p450; cl12078 373994012558 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 373994012559 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 373994012560 [2Fe-2S] cluster binding site [ion binding]; other site 373994012561 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 373994012562 hydrophobic ligand binding site; other site 373994012563 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994012564 Cytochrome P450; Region: p450; cl12078 373994012565 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994012566 Cytochrome P450; Region: p450; cl12078 373994012567 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 373994012568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994012569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373994012570 putative substrate translocation pore; other site 373994012571 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 373994012572 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994012573 phosphopeptide binding site; other site 373994012574 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 373994012575 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 373994012576 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 373994012577 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994012578 dimerization interface [polypeptide binding]; other site 373994012579 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 373994012580 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994012581 dimerization interface [polypeptide binding]; other site 373994012582 Caspase domain; Region: Peptidase_C14; pfam00656 373994012583 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 373994012584 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373994012585 DNA binding residues [nucleotide binding] 373994012586 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994012587 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 373994012588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994012589 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 373994012590 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 373994012591 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 373994012592 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 373994012593 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 373994012594 S-layer homology domain; Region: SLH; pfam00395 373994012595 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 373994012596 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 373994012597 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 373994012598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994012599 catalytic residue [active] 373994012600 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 373994012601 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 373994012602 substrate binding site [chemical binding]; other site 373994012603 active site 373994012604 catalytic residues [active] 373994012605 heterodimer interface [polypeptide binding]; other site 373994012606 anthranilate synthase; Provisional; Region: PRK13566 373994012607 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 373994012608 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 373994012609 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 373994012610 glutamine binding [chemical binding]; other site 373994012611 catalytic triad [active] 373994012612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 373994012613 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 373994012614 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 373994012615 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 373994012616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994012617 Walker A/P-loop; other site 373994012618 ATP binding site [chemical binding]; other site 373994012619 Q-loop/lid; other site 373994012620 ABC transporter signature motif; other site 373994012621 Walker B; other site 373994012622 D-loop; other site 373994012623 H-loop/switch region; other site 373994012624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994012625 S-adenosylmethionine binding site [chemical binding]; other site 373994012626 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 373994012627 active site 373994012628 metal-binding site [ion binding] 373994012629 nucleotide-binding site [chemical binding]; other site 373994012630 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 373994012631 active site 373994012632 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 373994012633 dimer interface [polypeptide binding]; other site 373994012634 Asparagine synthase; Region: Asn_synthase; pfam00733 373994012635 Asparagine synthase; Region: Asn_synthase; pfam00733 373994012636 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 373994012637 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 373994012638 cyclase homology domain; Region: CHD; cd07302 373994012639 nucleotidyl binding site; other site 373994012640 metal binding site [ion binding]; metal-binding site 373994012641 dimer interface [polypeptide binding]; other site 373994012642 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 373994012643 Leucine-rich repeats; other site 373994012644 Substrate binding site [chemical binding]; other site 373994012645 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994012646 Leucine rich repeat; Region: LRR_8; pfam13855 373994012647 Leucine rich repeat; Region: LRR_8; pfam13855 373994012648 Leucine rich repeat; Region: LRR_8; pfam13855 373994012649 Leucine rich repeat; Region: LRR_8; pfam13855 373994012650 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994012651 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 373994012652 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373994012653 G1 box; other site 373994012654 GTP/Mg2+ binding site [chemical binding]; other site 373994012655 G2 box; other site 373994012656 Switch I region; other site 373994012657 G3 box; other site 373994012658 Switch II region; other site 373994012659 G4 box; other site 373994012660 G5 box; other site 373994012661 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 373994012662 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994012663 Uncharacterized conserved protein [Function unknown]; Region: COG2128 373994012664 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 373994012665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994012666 S-adenosylmethionine binding site [chemical binding]; other site 373994012667 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 373994012668 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 373994012669 Walker A/P-loop; other site 373994012670 ATP binding site [chemical binding]; other site 373994012671 Q-loop/lid; other site 373994012672 ABC transporter signature motif; other site 373994012673 Walker B; other site 373994012674 D-loop; other site 373994012675 H-loop/switch region; other site 373994012676 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 373994012677 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994012678 putative active site [active] 373994012679 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 373994012680 Putative phosphatase (DUF442); Region: DUF442; cl17385 373994012681 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 373994012682 RNA/DNA hybrid binding site [nucleotide binding]; other site 373994012683 active site 373994012684 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 373994012685 active site 373994012686 Predicted membrane protein [Function unknown]; Region: COG2324 373994012687 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 373994012688 ribosomal protein L21; Region: rpl21; CHL00075 373994012689 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 373994012690 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 373994012691 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373994012692 dimer interface [polypeptide binding]; other site 373994012693 putative metal binding site [ion binding]; other site 373994012694 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 373994012695 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 373994012696 catalytic residues [active] 373994012697 Recombinase; Region: Recombinase; pfam07508 373994012698 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 373994012699 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 373994012700 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 373994012701 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 373994012702 Predicted transcriptional regulator [Transcription]; Region: COG1959 373994012703 Transcriptional regulator; Region: Rrf2; cl17282 373994012704 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 373994012705 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 373994012706 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373994012707 active site 373994012708 SnoaL-like domain; Region: SnoaL_3; pfam13474 373994012709 Response regulator receiver domain; Region: Response_reg; pfam00072 373994012710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994012711 active site 373994012712 phosphorylation site [posttranslational modification] 373994012713 intermolecular recognition site; other site 373994012714 dimerization interface [polypeptide binding]; other site 373994012715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994012716 PAS fold; Region: PAS_3; pfam08447 373994012717 putative active site [active] 373994012718 heme pocket [chemical binding]; other site 373994012719 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994012720 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994012721 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994012722 putative active site [active] 373994012723 PAS fold; Region: PAS_3; pfam08447 373994012724 heme pocket [chemical binding]; other site 373994012725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994012726 PAS fold; Region: PAS_3; pfam08447 373994012727 putative active site [active] 373994012728 heme pocket [chemical binding]; other site 373994012729 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994012730 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994012731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994012732 dimer interface [polypeptide binding]; other site 373994012733 phosphorylation site [posttranslational modification] 373994012734 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994012735 GAF domain; Region: GAF; pfam01590 373994012736 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994012737 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994012738 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 373994012739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994012740 putative active site [active] 373994012741 heme pocket [chemical binding]; other site 373994012742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994012743 dimer interface [polypeptide binding]; other site 373994012744 phosphorylation site [posttranslational modification] 373994012745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994012746 ATP binding site [chemical binding]; other site 373994012747 Mg2+ binding site [ion binding]; other site 373994012748 G-X-G motif; other site 373994012749 Response regulator receiver domain; Region: Response_reg; pfam00072 373994012750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994012751 active site 373994012752 phosphorylation site [posttranslational modification] 373994012753 intermolecular recognition site; other site 373994012754 dimerization interface [polypeptide binding]; other site 373994012755 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 373994012756 MoaE homodimer interface [polypeptide binding]; other site 373994012757 MoaD interaction [polypeptide binding]; other site 373994012758 active site residues [active] 373994012759 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 373994012760 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 373994012761 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 373994012762 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994012763 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 373994012764 Peptidase family M23; Region: Peptidase_M23; pfam01551 373994012765 Late competence development protein ComFB; Region: ComFB; pfam10719 373994012766 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 373994012767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 373994012768 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 373994012769 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373994012770 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373994012771 DNA binding residues [nucleotide binding] 373994012772 Putative zinc-finger; Region: zf-HC2; pfam13490 373994012773 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 373994012774 putative active site pocket [active] 373994012775 dimerization interface [polypeptide binding]; other site 373994012776 putative catalytic residue [active] 373994012777 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 373994012778 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 373994012779 HIGH motif; other site 373994012780 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 373994012781 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 373994012782 active site 373994012783 KMSKS motif; other site 373994012784 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 373994012785 tRNA binding surface [nucleotide binding]; other site 373994012786 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 373994012787 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 373994012788 active site 373994012789 diaminopimelate epimerase; Provisional; Region: PRK13577 373994012790 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 373994012791 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 373994012792 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 373994012793 dimer interface [polypeptide binding]; other site 373994012794 catalytic triad [active] 373994012795 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 373994012796 Peptidase family M50; Region: Peptidase_M50; pfam02163 373994012797 active site 373994012798 putative substrate binding region [chemical binding]; other site 373994012799 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 373994012800 Peptidase family M50; Region: Peptidase_M50; pfam02163 373994012801 active site 373994012802 putative substrate binding region [chemical binding]; other site 373994012803 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 373994012804 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 373994012805 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 373994012806 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 373994012807 purine monophosphate binding site [chemical binding]; other site 373994012808 dimer interface [polypeptide binding]; other site 373994012809 putative catalytic residues [active] 373994012810 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 373994012811 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 373994012812 Predicted esterase [General function prediction only]; Region: COG0400 373994012813 Serine hydrolase (FSH1); Region: FSH1; pfam03959 373994012814 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 373994012815 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 373994012816 Flavoprotein; Region: Flavoprotein; pfam02441 373994012817 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 373994012818 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994012819 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994012820 active site 373994012821 ATP binding site [chemical binding]; other site 373994012822 substrate binding site [chemical binding]; other site 373994012823 activation loop (A-loop); other site 373994012824 Uncharacterized conserved protein [Function unknown]; Region: COG1262 373994012825 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 373994012826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994012827 TPR motif; other site 373994012828 TPR repeat; Region: TPR_11; pfam13414 373994012829 binding surface 373994012830 TPR repeat; Region: TPR_11; pfam13414 373994012831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994012832 binding surface 373994012833 TPR motif; other site 373994012834 TPR repeat; Region: TPR_11; pfam13414 373994012835 TPR repeat; Region: TPR_11; pfam13414 373994012836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994012837 binding surface 373994012838 TPR motif; other site 373994012839 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 373994012840 Peptidase family M50; Region: Peptidase_M50; pfam02163 373994012841 active site 373994012842 putative substrate binding region [chemical binding]; other site 373994012843 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 373994012844 Prephenate dehydratase; Region: PDT; pfam00800 373994012845 Chorismate mutase type II; Region: CM_2; cl00693 373994012846 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 373994012847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 373994012848 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 373994012849 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 373994012850 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 373994012851 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 373994012852 Na binding site [ion binding]; other site 373994012853 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 373994012854 oligomeric interface; other site 373994012855 putative active site [active] 373994012856 homodimer interface [polypeptide binding]; other site 373994012857 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 373994012858 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 373994012859 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 373994012860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994012861 FeS/SAM binding site; other site 373994012862 TRAM domain; Region: TRAM; cl01282 373994012863 RNA ligase; Region: RNA_ligase; pfam09414 373994012864 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 373994012865 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 373994012866 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 373994012867 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 373994012868 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994012869 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373994012870 dimerization interface [polypeptide binding]; other site 373994012871 putative DNA binding site [nucleotide binding]; other site 373994012872 putative Zn2+ binding site [ion binding]; other site 373994012873 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 373994012874 putative hydrophobic ligand binding site [chemical binding]; other site 373994012875 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 373994012876 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 373994012877 C-terminal domain interface [polypeptide binding]; other site 373994012878 GSH binding site (G-site) [chemical binding]; other site 373994012879 dimer interface [polypeptide binding]; other site 373994012880 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 373994012881 N-terminal domain interface [polypeptide binding]; other site 373994012882 Cupin domain; Region: Cupin_2; cl17218 373994012883 SnoaL-like domain; Region: SnoaL_2; pfam12680 373994012884 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 373994012885 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 373994012886 active site 373994012887 catalytic residues [active] 373994012888 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 373994012889 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994012890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994012891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 373994012892 Coenzyme A binding pocket [chemical binding]; other site 373994012893 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994012894 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994012895 M28 Zn-Peptidases; Region: M28_like_1; cd05640 373994012896 Peptidase family M28; Region: Peptidase_M28; pfam04389 373994012897 metal binding site [ion binding]; metal-binding site 373994012898 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 373994012899 Family of unknown function (DUF490); Region: DUF490; pfam04357 373994012900 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 373994012901 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 373994012902 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 373994012903 putative active site [active] 373994012904 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 373994012905 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 373994012906 G1 box; other site 373994012907 GTP/Mg2+ binding site [chemical binding]; other site 373994012908 G2 box; other site 373994012909 Switch I region; other site 373994012910 G3 box; other site 373994012911 Switch II region; other site 373994012912 G4 box; other site 373994012913 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 373994012914 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994012915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994012916 active site 373994012917 phosphorylation site [posttranslational modification] 373994012918 intermolecular recognition site; other site 373994012919 dimerization interface [polypeptide binding]; other site 373994012920 Response regulator receiver domain; Region: Response_reg; pfam00072 373994012921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994012922 active site 373994012923 phosphorylation site [posttranslational modification] 373994012924 intermolecular recognition site; other site 373994012925 dimerization interface [polypeptide binding]; other site 373994012926 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 373994012927 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994012928 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994012929 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994012930 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994012931 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994012932 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994012933 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994012934 GAF domain; Region: GAF; pfam01590 373994012935 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373994012936 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373994012937 dimer interface [polypeptide binding]; other site 373994012938 putative CheW interface [polypeptide binding]; other site 373994012939 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 373994012940 four helix bundle protein; Region: TIGR02436 373994012941 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373994012942 putative binding surface; other site 373994012943 active site 373994012944 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 373994012945 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 373994012946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994012947 ATP binding site [chemical binding]; other site 373994012948 Mg2+ binding site [ion binding]; other site 373994012949 G-X-G motif; other site 373994012950 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 373994012951 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994012952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994012953 active site 373994012954 phosphorylation site [posttranslational modification] 373994012955 intermolecular recognition site; other site 373994012956 dimerization interface [polypeptide binding]; other site 373994012957 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 373994012958 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 373994012959 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 373994012960 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 373994012961 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994012962 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 373994012963 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 373994012964 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 373994012965 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 373994012966 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 373994012967 active site 373994012968 dimerization interface [polypeptide binding]; other site 373994012969 metal binding site [ion binding]; metal-binding site 373994012970 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 373994012971 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 373994012972 anti sigma factor interaction site; other site 373994012973 regulatory phosphorylation site [posttranslational modification]; other site 373994012974 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 373994012975 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 373994012976 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 373994012977 catalytic site [active] 373994012978 subunit interface [polypeptide binding]; other site 373994012979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 373994012980 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 373994012981 Probable transposase; Region: OrfB_IS605; pfam01385 373994012982 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 373994012983 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 373994012984 catalytic motif [active] 373994012985 Catalytic residue [active] 373994012986 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 373994012987 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 373994012988 active site 373994012989 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 373994012990 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 373994012991 Dynamin family; Region: Dynamin_N; pfam00350 373994012992 G1 box; other site 373994012993 GTP/Mg2+ binding site [chemical binding]; other site 373994012994 G2 box; other site 373994012995 Switch I region; other site 373994012996 G3 box; other site 373994012997 Switch II region; other site 373994012998 G4 box; other site 373994012999 G5 box; other site 373994013000 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373994013001 HSP70 interaction site [polypeptide binding]; other site 373994013002 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373994013003 Dynamin family; Region: Dynamin_N; pfam00350 373994013004 G1 box; other site 373994013005 GTP/Mg2+ binding site [chemical binding]; other site 373994013006 G2 box; other site 373994013007 Switch I region; other site 373994013008 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 373994013009 G3 box; other site 373994013010 Switch II region; other site 373994013011 GTP/Mg2+ binding site [chemical binding]; other site 373994013012 G4 box; other site 373994013013 G5 box; other site 373994013014 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 373994013015 YcfA-like protein; Region: YcfA; cl00752 373994013016 YcfA-like protein; Region: YcfA; cl00752 373994013017 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 373994013018 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 373994013019 dimer interface [polypeptide binding]; other site 373994013020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994013021 catalytic residue [active] 373994013022 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 373994013023 dimer interface [polypeptide binding]; other site 373994013024 [2Fe-2S] cluster binding site [ion binding]; other site 373994013025 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 373994013026 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 373994013027 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 373994013028 ribonuclease E; Reviewed; Region: rne; PRK10811 373994013029 AAA ATPase domain; Region: AAA_16; pfam13191 373994013030 NB-ARC domain; Region: NB-ARC; pfam00931 373994013031 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013032 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994013034 TPR motif; other site 373994013035 binding surface 373994013036 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994013038 binding surface 373994013039 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013040 TPR motif; other site 373994013041 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994013043 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013044 binding surface 373994013045 TPR motif; other site 373994013046 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013047 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013048 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994013050 binding surface 373994013051 TPR motif; other site 373994013052 TPR repeat; Region: TPR_11; pfam13414 373994013053 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994013054 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994013055 active site 373994013056 ATP binding site [chemical binding]; other site 373994013057 substrate binding site [chemical binding]; other site 373994013058 activation loop (A-loop); other site 373994013059 Bacterial SH3 domain; Region: SH3_3; pfam08239 373994013060 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 373994013061 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 373994013062 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 373994013063 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 373994013064 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 373994013065 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 373994013066 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 373994013067 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 373994013068 Domain of unknown function DUF11; Region: DUF11; cl17728 373994013069 Right handed beta helix region; Region: Beta_helix; pfam13229 373994013070 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 373994013071 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 373994013072 ligand binding site [chemical binding]; other site 373994013073 conserved repeat domain; Region: B_ant_repeat; TIGR01451 373994013074 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 373994013075 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 373994013076 hypothetical protein; Provisional; Region: PRK04194 373994013077 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 373994013078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994013079 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994013080 putative active site [active] 373994013081 heme pocket [chemical binding]; other site 373994013082 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994013083 putative active site [active] 373994013084 heme pocket [chemical binding]; other site 373994013085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 373994013086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994013087 dimer interface [polypeptide binding]; other site 373994013088 phosphorylation site [posttranslational modification] 373994013089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994013090 ATP binding site [chemical binding]; other site 373994013091 Mg2+ binding site [ion binding]; other site 373994013092 G-X-G motif; other site 373994013093 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 373994013094 Protein of unknown function (DUF751); Region: DUF751; pfam05421 373994013095 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 373994013096 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 373994013097 phosphoenolpyruvate synthase; Validated; Region: PRK06464 373994013098 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 373994013099 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 373994013100 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 373994013101 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 373994013102 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 373994013103 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 373994013104 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 373994013105 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994013106 Phytochrome region; Region: PHY; pfam00360 373994013107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994013108 dimer interface [polypeptide binding]; other site 373994013109 phosphorylation site [posttranslational modification] 373994013110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994013111 ATP binding site [chemical binding]; other site 373994013112 Mg2+ binding site [ion binding]; other site 373994013113 G-X-G motif; other site 373994013114 Response regulator receiver domain; Region: Response_reg; pfam00072 373994013115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994013116 active site 373994013117 phosphorylation site [posttranslational modification] 373994013118 intermolecular recognition site; other site 373994013119 dimerization interface [polypeptide binding]; other site 373994013120 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994013121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994013122 active site 373994013123 phosphorylation site [posttranslational modification] 373994013124 intermolecular recognition site; other site 373994013125 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 373994013126 dimerization interface [polypeptide binding]; other site 373994013127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994013128 dimer interface [polypeptide binding]; other site 373994013129 phosphorylation site [posttranslational modification] 373994013130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994013131 ATP binding site [chemical binding]; other site 373994013132 Mg2+ binding site [ion binding]; other site 373994013133 G-X-G motif; other site 373994013134 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994013135 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 373994013136 Predicted transcriptional regulators [Transcription]; Region: COG1695 373994013137 Transcriptional regulator PadR-like family; Region: PadR; cl17335 373994013138 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 373994013139 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 373994013140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994013141 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994013142 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994013143 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 373994013144 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373994013145 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373994013146 PemK-like protein; Region: PemK; pfam02452 373994013147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994013148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994013149 short chain dehydrogenase; Provisional; Region: PRK06500 373994013150 classical (c) SDRs; Region: SDR_c; cd05233 373994013151 NAD(P) binding site [chemical binding]; other site 373994013152 active site 373994013153 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 373994013154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994013155 NAD(P) binding site [chemical binding]; other site 373994013156 active site 373994013157 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994013158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994013159 S-adenosylmethionine binding site [chemical binding]; other site 373994013160 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994013161 GAF domain; Region: GAF; pfam01590 373994013162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994013163 ATP binding site [chemical binding]; other site 373994013164 Mg2+ binding site [ion binding]; other site 373994013165 G-X-G motif; other site 373994013166 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 373994013167 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 373994013168 active site 373994013169 catalytic site [active] 373994013170 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 373994013171 starch-binding site 2 [chemical binding]; other site 373994013172 starch-binding site 1 [chemical binding]; other site 373994013173 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994013174 putative active site [active] 373994013175 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 373994013176 dimerization interface [polypeptide binding]; other site 373994013177 putative active cleft [active] 373994013178 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994013179 structural tetrad; other site 373994013180 PQQ-like domain; Region: PQQ_2; pfam13360 373994013181 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 373994013182 homodimer interaction site [polypeptide binding]; other site 373994013183 cofactor binding site; other site 373994013184 Peptidase family M48; Region: Peptidase_M48; cl12018 373994013185 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 373994013186 putative heme binding site [chemical binding]; other site 373994013187 Phosphotransferase enzyme family; Region: APH; pfam01636 373994013188 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 373994013189 substrate binding site [chemical binding]; other site 373994013190 Tic20-like protein; Region: Tic20; pfam09685 373994013191 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 373994013192 apolar tunnel; other site 373994013193 heme binding site [chemical binding]; other site 373994013194 dimerization interface [polypeptide binding]; other site 373994013195 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 373994013196 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 373994013197 motif 1; other site 373994013198 active site 373994013199 motif 2; other site 373994013200 motif 3; other site 373994013201 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 373994013202 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 373994013203 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373994013204 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373994013205 metal binding site [ion binding]; metal-binding site 373994013206 active site 373994013207 I-site; other site 373994013208 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 373994013209 active site 373994013210 nucleophile elbow; other site 373994013211 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 373994013212 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 373994013213 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 373994013214 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 373994013215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994013216 Walker A/P-loop; other site 373994013217 ATP binding site [chemical binding]; other site 373994013218 Q-loop/lid; other site 373994013219 ABC transporter signature motif; other site 373994013220 Walker B; other site 373994013221 D-loop; other site 373994013222 H-loop/switch region; other site 373994013223 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 373994013224 S-layer homology domain; Region: SLH; pfam00395 373994013225 S-layer homology domain; Region: SLH; pfam00395 373994013226 S-layer homology domain; Region: SLH; pfam00395 373994013227 S-layer homology domain; Region: SLH; pfam00395 373994013228 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 373994013229 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 373994013230 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 373994013231 thiamine phosphate binding site [chemical binding]; other site 373994013232 active site 373994013233 pyrophosphate binding site [ion binding]; other site 373994013234 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 373994013235 thiS-thiF/thiG interaction site; other site 373994013236 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 373994013237 Leucine rich repeat; Region: LRR_8; pfam13855 373994013238 Leucine-rich repeats; other site 373994013239 Substrate binding site [chemical binding]; other site 373994013240 Leucine rich repeat; Region: LRR_8; pfam13855 373994013241 Leucine rich repeat; Region: LRR_8; pfam13855 373994013242 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 373994013243 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373994013244 G1 box; other site 373994013245 GTP/Mg2+ binding site [chemical binding]; other site 373994013246 G2 box; other site 373994013247 Switch I region; other site 373994013248 G3 box; other site 373994013249 Switch II region; other site 373994013250 G4 box; other site 373994013251 G5 box; other site 373994013252 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 373994013253 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 373994013254 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 373994013255 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 373994013256 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 373994013257 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 373994013258 DNA binding residues [nucleotide binding] 373994013259 dimer interface [polypeptide binding]; other site 373994013260 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 373994013261 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 373994013262 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 373994013263 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 373994013264 C-terminal domain interface [polypeptide binding]; other site 373994013265 active site 373994013266 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 373994013267 active site 373994013268 N-terminal domain interface [polypeptide binding]; other site 373994013269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994013270 putative substrate translocation pore; other site 373994013271 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 373994013272 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 373994013273 PYR/PP interface [polypeptide binding]; other site 373994013274 dimer interface [polypeptide binding]; other site 373994013275 TPP binding site [chemical binding]; other site 373994013276 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 373994013277 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 373994013278 TPP-binding site [chemical binding]; other site 373994013279 dimer interface [polypeptide binding]; other site 373994013280 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 373994013281 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 373994013282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994013283 dimer interface [polypeptide binding]; other site 373994013284 conserved gate region; other site 373994013285 putative PBP binding loops; other site 373994013286 ABC-ATPase subunit interface; other site 373994013287 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994013288 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994013289 CHASE2 domain; Region: CHASE2; pfam05226 373994013290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994013291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994013292 dimer interface [polypeptide binding]; other site 373994013293 phosphorylation site [posttranslational modification] 373994013294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994013295 ATP binding site [chemical binding]; other site 373994013296 Mg2+ binding site [ion binding]; other site 373994013297 G-X-G motif; other site 373994013298 Response regulator receiver domain; Region: Response_reg; pfam00072 373994013299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994013300 active site 373994013301 phosphorylation site [posttranslational modification] 373994013302 intermolecular recognition site; other site 373994013303 dimerization interface [polypeptide binding]; other site 373994013304 Response regulator receiver domain; Region: Response_reg; pfam00072 373994013305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994013306 active site 373994013307 phosphorylation site [posttranslational modification] 373994013308 intermolecular recognition site; other site 373994013309 dimerization interface [polypeptide binding]; other site 373994013310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994013311 dimer interface [polypeptide binding]; other site 373994013312 phosphorylation site [posttranslational modification] 373994013313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994013314 ATP binding site [chemical binding]; other site 373994013315 Mg2+ binding site [ion binding]; other site 373994013316 G-X-G motif; other site 373994013317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 373994013318 binding surface 373994013319 TPR motif; other site 373994013320 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 373994013322 binding surface 373994013323 TPR motif; other site 373994013324 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 373994013326 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994013327 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994013328 active site 373994013329 ATP binding site [chemical binding]; other site 373994013330 substrate binding site [chemical binding]; other site 373994013331 activation loop (A-loop); other site 373994013332 Uncharacterized conserved protein [Function unknown]; Region: COG1262 373994013333 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 373994013334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994013335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994013336 dimer interface [polypeptide binding]; other site 373994013337 phosphorylation site [posttranslational modification] 373994013338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994013339 ATP binding site [chemical binding]; other site 373994013340 G-X-G motif; other site 373994013341 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 373994013342 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 373994013343 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 373994013344 Chain length determinant protein; Region: Wzz; cl15801 373994013345 chain length determinant protein EpsF; Region: EpsF; TIGR03017 373994013346 AAA domain; Region: AAA_31; pfam13614 373994013347 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 373994013348 Magnesium ion binding site [ion binding]; other site 373994013349 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994013350 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994013351 active site 373994013352 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994013353 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373994013354 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994013355 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994013356 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994013357 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 373994013358 colanic acid exporter; Provisional; Region: PRK10459 373994013359 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 373994013360 Acyltransferase family; Region: Acyl_transf_3; pfam01757 373994013361 Electron transfer DM13; Region: DM13; pfam10517 373994013362 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994013363 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994013364 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994013365 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013366 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013367 CHAT domain; Region: CHAT; cl17868 373994013368 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 373994013369 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 373994013370 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 373994013371 putative active site [active] 373994013372 putative substrate binding site [chemical binding]; other site 373994013373 putative cosubstrate binding site; other site 373994013374 catalytic site [active] 373994013375 AAA ATPase domain; Region: AAA_16; pfam13191 373994013376 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994013377 CHASE2 domain; Region: CHASE2; pfam05226 373994013378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 373994013379 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 373994013380 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994013381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994013382 active site 373994013383 phosphorylation site [posttranslational modification] 373994013384 intermolecular recognition site; other site 373994013385 DNA binding residues [nucleotide binding] 373994013386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 373994013387 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994013388 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 373994013389 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 373994013390 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 373994013391 catalytic triad [active] 373994013392 CHAT domain; Region: CHAT; cl17868 373994013393 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 373994013394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994013395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 373994013396 dimerization interface [polypeptide binding]; other site 373994013397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994013398 dimer interface [polypeptide binding]; other site 373994013399 phosphorylation site [posttranslational modification] 373994013400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994013401 ATP binding site [chemical binding]; other site 373994013402 Mg2+ binding site [ion binding]; other site 373994013403 G-X-G motif; other site 373994013404 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994013405 Uncharacterized conserved protein [Function unknown]; Region: COG1359 373994013406 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 373994013407 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 373994013408 active site 373994013409 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 373994013410 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 373994013411 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 373994013412 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 373994013413 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 373994013414 conserved cys residue [active] 373994013415 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 373994013416 dimerization interface [polypeptide binding]; other site 373994013417 putative active cleft [active] 373994013418 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 373994013419 putative catalytic residues [active] 373994013420 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 373994013421 anti sigma factor interaction site; other site 373994013422 regulatory phosphorylation site [posttranslational modification]; other site 373994013423 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 373994013424 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234 373994013425 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 373994013426 active site 373994013427 catalytic site [active] 373994013428 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 373994013429 anti sigma factor interaction site; other site 373994013430 regulatory phosphorylation site [posttranslational modification]; other site 373994013431 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 373994013432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 373994013433 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 373994013434 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 373994013435 chromosome segregation protein; Provisional; Region: PRK02224 373994013436 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373994013437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994013438 putative substrate translocation pore; other site 373994013439 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 373994013440 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373994013441 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 373994013442 Uncharacterized family of heme peroxidases, mostly bacterial; Region: peroxinectin_like_bacterial; cd09822 373994013443 putative heme binding site [chemical binding]; other site 373994013444 putative substrate binding site [chemical binding]; other site 373994013445 Calx-beta domain; Region: Calx-beta; pfam03160 373994013446 Protein of unknown function, DUF393; Region: DUF393; pfam04134 373994013447 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 373994013448 DNA binding residues [nucleotide binding] 373994013449 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 373994013450 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 373994013451 catalytic residues [active] 373994013452 catalytic nucleophile [active] 373994013453 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 373994013454 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 373994013455 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 373994013456 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 373994013457 PYR/PP interface [polypeptide binding]; other site 373994013458 dimer interface [polypeptide binding]; other site 373994013459 TPP binding site [chemical binding]; other site 373994013460 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 373994013461 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 373994013462 TPP-binding site [chemical binding]; other site 373994013463 hypothetical protein; Validated; Region: PRK06840 373994013464 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 373994013465 active site 373994013466 Predicted ATPase [General function prediction only]; Region: COG3899 373994013467 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 373994013468 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994013469 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 373994013470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 373994013471 PAS domain; Region: PAS_9; pfam13426 373994013472 putative active site [active] 373994013473 heme pocket [chemical binding]; other site 373994013474 PAS domain; Region: PAS_9; pfam13426 373994013475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 373994013476 putative active site [active] 373994013477 heme pocket [chemical binding]; other site 373994013478 Caspase domain; Region: Peptidase_C14; pfam00656 373994013479 GUN4-like; Region: GUN4; pfam05419 373994013480 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 373994013481 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994013482 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994013483 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994013484 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994013485 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994013486 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994013487 DevC protein; Region: devC; TIGR01185 373994013488 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994013489 FtsX-like permease family; Region: FtsX; pfam02687 373994013490 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 373994013491 Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229 373994013492 Ion channel; Region: Ion_trans_2; pfam07885 373994013493 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 373994013494 TrkA-N domain; Region: TrkA_N; pfam02254 373994013495 TrkA-C domain; Region: TrkA_C; pfam02080 373994013496 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 373994013497 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994013498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994013499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994013500 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 373994013501 SnoaL-like domain; Region: SnoaL_3; pfam13474 373994013502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994013503 S-adenosylmethionine binding site [chemical binding]; other site 373994013504 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 373994013505 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 373994013506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 373994013507 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 373994013508 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373994013509 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 373994013510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994013511 putative substrate translocation pore; other site 373994013512 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373994013513 Family description; Region: VCBS; pfam13517 373994013514 Family description; Region: VCBS; pfam13517 373994013515 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 373994013516 Ca2+ binding site [ion binding]; other site 373994013517 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 373994013518 Family description; Region: VCBS; pfam13517 373994013519 Family description; Region: VCBS; pfam13517 373994013520 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 373994013521 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 373994013522 NAD(P) binding site [chemical binding]; other site 373994013523 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373994013524 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373994013525 active site 373994013526 catalytic tetrad [active] 373994013527 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994013528 structural tetrad; other site 373994013529 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994013530 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994013531 structural tetrad; other site 373994013532 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994013533 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 373994013534 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373994013535 active site 373994013536 metal binding site [ion binding]; metal-binding site 373994013537 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 373994013538 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 373994013539 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 373994013540 C-terminal domain interface [polypeptide binding]; other site 373994013541 GSH binding site (G-site) [chemical binding]; other site 373994013542 dimer interface [polypeptide binding]; other site 373994013543 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 373994013544 N-terminal domain interface [polypeptide binding]; other site 373994013545 dimer interface [polypeptide binding]; other site 373994013546 substrate binding pocket (H-site) [chemical binding]; other site 373994013547 Helix-turn-helix domain; Region: HTH_17; pfam12728 373994013548 hypothetical protein; Provisional; Region: PRK06126 373994013549 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 373994013550 Ferritin-like; Region: Ferritin-like; pfam12902 373994013551 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 373994013552 Sodium Bile acid symporter family; Region: SBF; cl17470 373994013553 S-layer homology domain; Region: SLH; pfam00395 373994013554 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 373994013555 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 373994013556 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 373994013557 Imelysin; Region: Peptidase_M75; pfam09375 373994013558 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 373994013559 YwiC-like protein; Region: YwiC; pfam14256 373994013560 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 373994013561 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 373994013562 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 373994013563 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 373994013564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994013565 dimer interface [polypeptide binding]; other site 373994013566 conserved gate region; other site 373994013567 putative PBP binding loops; other site 373994013568 ABC-ATPase subunit interface; other site 373994013569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994013570 dimer interface [polypeptide binding]; other site 373994013571 conserved gate region; other site 373994013572 putative PBP binding loops; other site 373994013573 ABC-ATPase subunit interface; other site 373994013574 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 373994013575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994013576 Walker A/P-loop; other site 373994013577 ATP binding site [chemical binding]; other site 373994013578 Q-loop/lid; other site 373994013579 ABC transporter signature motif; other site 373994013580 Walker B; other site 373994013581 D-loop; other site 373994013582 H-loop/switch region; other site 373994013583 TOBE domain; Region: TOBE_2; pfam08402 373994013584 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 373994013585 MltA specific insert domain; Region: MltA; pfam03562 373994013586 3D domain; Region: 3D; pfam06725 373994013587 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 373994013588 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994013589 FeS/SAM binding site; other site 373994013590 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 373994013591 Photosystem II protein; Region: PSII; cl08223 373994013592 Photosystem II protein; Region: PSII; cl08223 373994013593 flavodoxin FldA; Validated; Region: PRK09267 373994013594 Photosystem II protein; Region: PSII; cl08223 373994013595 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 373994013596 GAF domain; Region: GAF_3; pfam13492 373994013597 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994013598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994013599 dimer interface [polypeptide binding]; other site 373994013600 phosphorylation site [posttranslational modification] 373994013601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994013602 ATP binding site [chemical binding]; other site 373994013603 Mg2+ binding site [ion binding]; other site 373994013604 G-X-G motif; other site 373994013605 Uncharacterized conserved protein [Function unknown]; Region: COG3287 373994013606 FIST N domain; Region: FIST; pfam08495 373994013607 FIST C domain; Region: FIST_C; pfam10442 373994013608 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 373994013609 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 373994013610 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 373994013611 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 373994013612 active site 373994013613 metal binding site [ion binding]; metal-binding site 373994013614 hexamer interface [polypeptide binding]; other site 373994013615 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 373994013616 active site 373994013617 catalytic residues [active] 373994013618 DNA binding site [nucleotide binding] 373994013619 Int/Topo IB signature motif; other site 373994013620 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994013621 putative active site [active] 373994013622 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994013623 putative active site [active] 373994013624 Transcriptional regulators [Transcription]; Region: MarR; COG1846 373994013625 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373994013626 putative DNA binding site [nucleotide binding]; other site 373994013627 putative Zn2+ binding site [ion binding]; other site 373994013628 replicative DNA helicase; Region: DnaB; TIGR00665 373994013629 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 373994013630 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 373994013631 Walker A motif; other site 373994013632 ATP binding site [chemical binding]; other site 373994013633 Walker B motif; other site 373994013634 AAA-like domain; Region: AAA_10; pfam12846 373994013635 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 373994013636 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 373994013637 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 373994013638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994013639 Walker A motif; other site 373994013640 ATP binding site [chemical binding]; other site 373994013641 Walker B motif; other site 373994013642 arginine finger; other site 373994013643 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 373994013644 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 373994013645 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373994013646 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994013647 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 373994013648 putative effector binding pocket; other site 373994013649 dimerization interface [polypeptide binding]; other site 373994013650 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 373994013651 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 373994013652 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 373994013653 NADP binding site [chemical binding]; other site 373994013654 dimer interface [polypeptide binding]; other site 373994013655 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 373994013656 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 373994013657 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373994013658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994013659 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 373994013660 putative effector binding pocket; other site 373994013661 dimerization interface [polypeptide binding]; other site 373994013662 Uncharacterized conserved protein [Function unknown]; Region: COG1359 373994013663 SnoaL-like domain; Region: SnoaL_2; pfam12680 373994013664 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 373994013665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994013666 NAD(P) binding site [chemical binding]; other site 373994013667 active site 373994013668 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 373994013669 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 373994013670 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 373994013671 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 373994013672 Mg binding site [ion binding]; other site 373994013673 nucleotide binding site [chemical binding]; other site 373994013674 putative protofilament interface [polypeptide binding]; other site 373994013675 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994013676 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 373994013677 Clostripain family; Region: Peptidase_C11; pfam03415 373994013678 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 373994013679 active site 373994013680 GIY-YIG motif/motif A; other site 373994013681 catalytic site [active] 373994013682 metal binding site [ion binding]; metal-binding site 373994013683 Methyltransferase domain; Region: Methyltransf_26; pfam13659 373994013684 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 373994013685 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 373994013686 DEAD-like helicases superfamily; Region: DEXDc; smart00487 373994013687 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 373994013688 helicase superfamily c-terminal domain; Region: HELICc; smart00490 373994013689 Antirestriction protein (ArdA); Region: ArdA; pfam07275 373994013690 hypothetical protein; Reviewed; Region: PRK12275 373994013691 four helix bundle protein; Region: TIGR02436 373994013692 Restriction endonuclease; Region: Mrr_cat; pfam04471 373994013693 NACHT domain; Region: NACHT; pfam05729 373994013694 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994013695 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994013696 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994013697 structural tetrad; other site 373994013698 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994013699 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994013700 structural tetrad; other site 373994013701 WYL domain; Region: WYL; cl14852 373994013702 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 373994013703 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373994013704 Zn2+ binding site [ion binding]; other site 373994013705 Mg2+ binding site [ion binding]; other site 373994013706 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 373994013707 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 373994013708 putative active site [active] 373994013709 putative NTP binding site [chemical binding]; other site 373994013710 putative nucleic acid binding site [nucleotide binding]; other site 373994013711 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 373994013712 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 373994013713 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 373994013714 Integrase core domain; Region: rve; pfam00665 373994013715 AAA domain; Region: AAA_22; pfam13401 373994013716 TniQ; Region: TniQ; pfam06527 373994013717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994013718 sequence-specific DNA binding site [nucleotide binding]; other site 373994013719 salt bridge; other site 373994013720 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 373994013721 Uncharacterized conserved protein [Function unknown]; Region: COG1432 373994013722 LabA_like proteins; Region: LabA_like/DUF88; cl10034 373994013723 putative metal binding site [ion binding]; other site 373994013724 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 373994013725 Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462 373994013726 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 373994013727 ATP binding site [chemical binding]; other site 373994013728 substrate interface [chemical binding]; other site 373994013729 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 373994013730 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 373994013731 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 373994013732 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 373994013733 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 373994013734 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 373994013735 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 373994013736 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742 373994013737 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 373994013738 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 373994013739 GIY-YIG motif/motif A; other site 373994013740 active site 373994013741 catalytic site [active] 373994013742 metal binding site [ion binding]; metal-binding site 373994013743 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 373994013744 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 373994013745 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 373994013746 active site 373994013747 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994013748 putative active site [active] 373994013749 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 373994013750 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 373994013751 Peptidase family M23; Region: Peptidase_M23; pfam01551 373994013752 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 373994013753 N-acetyl-D-glucosamine binding site [chemical binding]; other site 373994013754 catalytic residue [active] 373994013755 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 373994013756 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 373994013757 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 373994013758 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 373994013759 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 373994013760 ATP binding site [chemical binding]; other site 373994013761 substrate interface [chemical binding]; other site 373994013762 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 373994013763 active site 373994013764 NTP binding site [chemical binding]; other site 373994013765 metal binding triad [ion binding]; metal-binding site 373994013766 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 373994013767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994013768 non-specific DNA binding site [nucleotide binding]; other site 373994013769 salt bridge; other site 373994013770 sequence-specific DNA binding site [nucleotide binding]; other site 373994013771 Domain of unknown function (DUF955); Region: DUF955; pfam06114 373994013772 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 373994013773 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 373994013774 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 373994013775 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 373994013776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994013777 non-specific DNA binding site [nucleotide binding]; other site 373994013778 salt bridge; other site 373994013779 sequence-specific DNA binding site [nucleotide binding]; other site 373994013780 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 373994013781 Methyltransferase domain; Region: Methyltransf_26; pfam13659 373994013782 AAA domain; Region: AAA_21; pfam13304 373994013783 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 373994013784 Nuclease-related domain; Region: NERD; pfam08378 373994013785 Protein kinase domain; Region: Pkinase; pfam00069 373994013786 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994013787 active site 373994013788 ATP binding site [chemical binding]; other site 373994013789 substrate binding site [chemical binding]; other site 373994013790 activation loop (A-loop); other site 373994013791 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994013792 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994013793 active site 373994013794 ATP binding site [chemical binding]; other site 373994013795 substrate binding site [chemical binding]; other site 373994013796 activation loop (A-loop); other site 373994013797 AAA-like domain; Region: AAA_10; pfam12846 373994013798 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 373994013799 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994013800 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994013801 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 373994013802 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 373994013803 putative active site [active] 373994013804 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994013805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994013806 Walker A/P-loop; other site 373994013807 ATP binding site [chemical binding]; other site 373994013808 Q-loop/lid; other site 373994013809 ABC transporter signature motif; other site 373994013810 Walker B; other site 373994013811 D-loop; other site 373994013812 H-loop/switch region; other site 373994013813 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 373994013814 DNA binding residues [nucleotide binding] 373994013815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994013816 NACHT domain; Region: NACHT; pfam05729 373994013817 Walker A motif; other site 373994013818 ATP binding site [chemical binding]; other site 373994013819 Walker B motif; other site 373994013820 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994013821 active site 373994013822 ATP binding site [chemical binding]; other site 373994013823 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994013824 substrate binding site [chemical binding]; other site 373994013825 activation loop (A-loop); other site 373994013826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994013827 binding surface 373994013828 TPR motif; other site 373994013829 TPR repeat; Region: TPR_11; pfam13414 373994013830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994013831 binding surface 373994013832 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013833 TPR motif; other site 373994013834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994013835 TPR repeat; Region: TPR_11; pfam13414 373994013836 binding surface 373994013837 TPR motif; other site 373994013838 CHAT domain; Region: CHAT; cl17868 373994013839 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 373994013840 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 373994013841 Surface antigen; Region: Bac_surface_Ag; pfam01103 373994013842 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994013843 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994013844 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994013845 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994013846 CHAT domain; Region: CHAT; cl17868 373994013847 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994013848 CHASE2 domain; Region: CHASE2; pfam05226 373994013849 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994013850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994013851 binding surface 373994013852 TPR motif; other site 373994013853 CHAT domain; Region: CHAT; cl17868 373994013854 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 373994013855 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 373994013856 Surface antigen; Region: Bac_surface_Ag; pfam01103 373994013857 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994013858 Phage minor tail protein L; Region: Phage_tail_L; cl01908 373994013859 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 373994013860 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994013861 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 373994013862 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 373994013863 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 373994013864 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 373994013865 putative active site [active] 373994013866 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994013867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994013868 Walker A/P-loop; other site 373994013869 ATP binding site [chemical binding]; other site 373994013870 Q-loop/lid; other site 373994013871 ABC transporter signature motif; other site 373994013872 Walker B; other site 373994013873 D-loop; other site 373994013874 H-loop/switch region; other site 373994013875 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 373994013876 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 373994013877 active site 373994013878 catalytic residues [active] 373994013879 PrcB C-terminal; Region: PrcB_C; pfam14343 373994013880 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 373994013881 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 373994013882 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994013883 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 373994013884 active site 373994013885 RNA/DNA hybrid binding site [nucleotide binding]; other site 373994013886 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 373994013887 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 373994013888 HipA N-terminal domain; Region: Couple_hipA; cl11853 373994013889 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 373994013890 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 373994013891 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 373994013892 DNA binding residues [nucleotide binding] 373994013893 HsdM N-terminal domain; Region: HsdM_N; pfam12161 373994013894 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 373994013895 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 373994013896 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 373994013897 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 373994013898 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 373994013899 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 373994013900 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994013901 ATP binding site [chemical binding]; other site 373994013902 putative Mg++ binding site [ion binding]; other site 373994013903 Protein of unknown function DUF45; Region: DUF45; cl00636 373994013904 TIGR04255 family protein; Region: sporadTIGR04255 373994013905 TniQ; Region: TniQ; pfam06527 373994013906 Bacterial TniB protein; Region: TniB; pfam05621 373994013907 AAA domain; Region: AAA_22; pfam13401 373994013908 Helix-turn-helix domain; Region: HTH_28; pfam13518 373994013909 Winged helix-turn helix; Region: HTH_29; pfam13551 373994013910 Homeodomain-like domain; Region: HTH_32; pfam13565 373994013911 Integrase core domain; Region: rve; pfam00665 373994013912 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 373994013913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994013914 TPR motif; other site 373994013915 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013916 binding surface 373994013917 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994013919 binding surface 373994013920 TPR motif; other site 373994013921 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013922 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994013924 TPR motif; other site 373994013925 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013926 binding surface 373994013927 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994013929 binding surface 373994013930 TPR motif; other site 373994013931 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994013933 binding surface 373994013934 TPR motif; other site 373994013935 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013936 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994013937 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 373994013938 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 373994013939 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 373994013940 putative active site [active] 373994013941 putative NTP binding site [chemical binding]; other site 373994013942 putative nucleic acid binding site [nucleotide binding]; other site 373994013943 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 373994013944 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 373994013945 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 373994013946 active site 373994013947 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 373994013948 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 373994013949 phage tail protein domain; Region: tail_TIGR02242 373994013950 Transposase [DNA replication, recombination, and repair]; Region: COG5433 373994013951 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 373994013952 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 373994013953 Catalytic site; other site 373994013954 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 373994013955 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 373994013956 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994013957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994013958 active site 373994013959 phosphorylation site [posttranslational modification] 373994013960 intermolecular recognition site; other site 373994013961 dimerization interface [polypeptide binding]; other site 373994013962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994013963 DNA binding site [nucleotide binding] 373994013964 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994013965 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994013966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994013967 dimer interface [polypeptide binding]; other site 373994013968 phosphorylation site [posttranslational modification] 373994013969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994013970 ATP binding site [chemical binding]; other site 373994013971 Mg2+ binding site [ion binding]; other site 373994013972 G-X-G motif; other site 373994013973 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994013974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994013975 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 373994013976 Domain of unknown function DUF302; Region: DUF302; pfam03625 373994013977 Predicted membrane protein [Function unknown]; Region: COG2855 373994013978 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 373994013979 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 373994013980 Active Sites [active] 373994013981 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 373994013982 ATP-sulfurylase; Region: ATPS; cd00517 373994013983 active site 373994013984 HXXH motif; other site 373994013985 flexible loop; other site 373994013986 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 373994013987 transmembrane helices; other site 373994013988 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 373994013989 TrkA-C domain; Region: TrkA_C; pfam02080 373994013990 TrkA-C domain; Region: TrkA_C; pfam02080 373994013991 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 373994013992 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 373994013993 putative efflux protein, MATE family; Region: matE; TIGR00797 373994013994 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 373994013995 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 373994013996 homodimer interface [polypeptide binding]; other site 373994013997 active site 373994013998 TDP-binding site; other site 373994013999 acceptor substrate-binding pocket; other site 373994014000 CHAT domain; Region: CHAT; cl17868 373994014001 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994014002 Leucine rich repeat; Region: LRR_8; pfam13855 373994014003 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994014004 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994014005 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994014006 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 373994014007 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994014008 Leucine-rich repeats; other site 373994014009 Substrate binding site [chemical binding]; other site 373994014010 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994014011 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994014012 Leucine rich repeat; Region: LRR_8; pfam13855 373994014013 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 373994014014 Leucine-rich repeats; other site 373994014015 Leucine rich repeat; Region: LRR_8; pfam13855 373994014016 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994014017 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 373994014018 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373994014019 G1 box; other site 373994014020 GTP/Mg2+ binding site [chemical binding]; other site 373994014021 G2 box; other site 373994014022 Switch I region; other site 373994014023 G3 box; other site 373994014024 Switch II region; other site 373994014025 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 373994014026 active site 373994014027 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994014028 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994014029 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994014030 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994014031 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994014032 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994014033 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994014034 GAF domain; Region: GAF; pfam01590 373994014035 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994014036 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994014037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994014038 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 373994014039 dimer interface [polypeptide binding]; other site 373994014040 phosphorylation site [posttranslational modification] 373994014041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994014042 ATP binding site [chemical binding]; other site 373994014043 Mg2+ binding site [ion binding]; other site 373994014044 G-X-G motif; other site 373994014045 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 373994014046 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373994014047 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 373994014048 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 373994014049 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 373994014050 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 373994014051 active site residue [active] 373994014052 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 373994014053 Uncharacterized conserved protein [Function unknown]; Region: COG3025 373994014054 Phycobilisome protein; Region: Phycobilisome; cl08227 373994014055 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994014056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994014057 active site 373994014058 phosphorylation site [posttranslational modification] 373994014059 intermolecular recognition site; other site 373994014060 dimerization interface [polypeptide binding]; other site 373994014061 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 373994014062 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 373994014063 Fasciclin domain; Region: Fasciclin; pfam02469 373994014064 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 373994014065 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 373994014066 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 373994014067 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 373994014068 dimer interface [polypeptide binding]; other site 373994014069 active site 373994014070 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373994014071 substrate binding site [chemical binding]; other site 373994014072 catalytic residue [active] 373994014073 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 373994014074 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994014075 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014076 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994014077 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014078 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014079 Uncharacterized conserved protein [Function unknown]; Region: COG0397 373994014080 hypothetical protein; Validated; Region: PRK00029 373994014081 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 373994014082 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 373994014083 putative active site [active] 373994014084 putative dimer interface [polypeptide binding]; other site 373994014085 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 373994014086 intersubunit interface [polypeptide binding]; other site 373994014087 active site 373994014088 Zn2+ binding site [ion binding]; other site 373994014089 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 373994014090 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 373994014091 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 373994014092 Cupin domain; Region: Cupin_2; cl17218 373994014093 Uncharacterized conserved protein [Function unknown]; Region: COG1434 373994014094 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 373994014095 putative active site [active] 373994014096 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 373994014097 DNA photolyase; Region: DNA_photolyase; pfam00875 373994014098 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994014099 FtsH Extracellular; Region: FtsH_ext; pfam06480 373994014100 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 373994014101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994014102 Walker A motif; other site 373994014103 ATP binding site [chemical binding]; other site 373994014104 Walker B motif; other site 373994014105 arginine finger; other site 373994014106 Peptidase family M41; Region: Peptidase_M41; pfam01434 373994014107 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 373994014108 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 373994014109 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 373994014110 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 373994014111 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 373994014112 Ca2+ binding site [ion binding]; other site 373994014113 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 373994014114 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 373994014115 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 373994014116 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 373994014117 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 373994014118 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 373994014119 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 373994014120 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 373994014121 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 373994014122 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 373994014123 acetylornithine aminotransferase; Provisional; Region: PRK02627 373994014124 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 373994014125 inhibitor-cofactor binding pocket; inhibition site 373994014126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994014127 catalytic residue [active] 373994014128 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 373994014129 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 373994014130 active site 373994014131 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 373994014132 active site 373994014133 iron coordination sites [ion binding]; other site 373994014134 TPR repeat; Region: TPR_11; pfam13414 373994014135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014136 binding surface 373994014137 TPR motif; other site 373994014138 ATP-grasp domain; Region: ATP-grasp_4; cl17255 373994014139 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 373994014140 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994014141 Domain of unknown function (DUF4315); Region: DUF4315; pfam14193 373994014142 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994014143 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 373994014144 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 373994014145 putative active site [active] 373994014146 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994014147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994014148 Walker A/P-loop; other site 373994014149 ATP binding site [chemical binding]; other site 373994014150 Q-loop/lid; other site 373994014151 ABC transporter signature motif; other site 373994014152 Walker B; other site 373994014153 D-loop; other site 373994014154 H-loop/switch region; other site 373994014155 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994014156 Predicted permeases [General function prediction only]; Region: COG0795 373994014157 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 373994014158 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 373994014159 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994014160 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994014161 DNA binding residues [nucleotide binding] 373994014162 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994014163 AAA ATPase domain; Region: AAA_16; pfam13191 373994014164 NB-ARC domain; Region: NB-ARC; pfam00931 373994014165 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994014166 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994014167 active site 373994014168 substrate binding site [chemical binding]; other site 373994014169 ATP binding site [chemical binding]; other site 373994014170 activation loop (A-loop); other site 373994014171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014172 TPR motif; other site 373994014173 binding surface 373994014174 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014176 binding surface 373994014177 TPR motif; other site 373994014178 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014179 TPR repeat; Region: TPR_11; pfam13414 373994014180 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 373994014182 binding surface 373994014183 TPR motif; other site 373994014184 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014186 binding surface 373994014187 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014188 TPR motif; other site 373994014189 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 373994014191 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 373994014192 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 373994014193 Surface antigen; Region: Bac_surface_Ag; pfam01103 373994014194 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994014195 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 373994014196 active site 373994014197 catalytic residues [active] 373994014198 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 373994014199 Substrate binding site [chemical binding]; other site 373994014200 ATP-grasp domain; Region: ATP-grasp_4; cl17255 373994014201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994014202 non-specific DNA binding site [nucleotide binding]; other site 373994014203 salt bridge; other site 373994014204 sequence-specific DNA binding site [nucleotide binding]; other site 373994014205 Sulfatase; Region: Sulfatase; cl17466 373994014206 coproporphyrinogen III oxidase; Validated; Region: PRK08208 373994014207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994014208 FeS/SAM binding site; other site 373994014209 HemN C-terminal domain; Region: HemN_C; pfam06969 373994014210 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 373994014211 Substrate binding site [chemical binding]; other site 373994014212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 373994014213 FeS/SAM binding site; other site 373994014214 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 373994014215 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 373994014216 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 373994014217 nucleotide binding site [chemical binding]; other site 373994014218 putative NEF/HSP70 interaction site [polypeptide binding]; other site 373994014219 SBD interface [polypeptide binding]; other site 373994014220 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994014221 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994014222 structural tetrad; other site 373994014223 XisI protein; Region: XisI; pfam08869 373994014224 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994014225 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994014226 structural tetrad; other site 373994014227 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 373994014228 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 373994014229 Ycf46; Provisional; Region: ycf46; CHL00195 373994014230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994014231 H-loop/switch region; other site 373994014232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994014233 Walker A motif; other site 373994014234 ATP binding site [chemical binding]; other site 373994014235 Walker B motif; other site 373994014236 arginine finger; other site 373994014237 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 373994014238 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 373994014239 active site 373994014240 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 373994014241 TPR repeat; Region: TPR_11; pfam13414 373994014242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014243 binding surface 373994014244 TPR motif; other site 373994014245 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014246 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 373994014248 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994014249 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994014250 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 373994014251 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 373994014252 Surface antigen; Region: Bac_surface_Ag; pfam01103 373994014253 CHAT domain; Region: CHAT; cl17868 373994014254 CHASE2 domain; Region: CHASE2; cl01732 373994014255 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994014256 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994014257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994014258 S-adenosylmethionine binding site [chemical binding]; other site 373994014259 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 373994014260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994014261 Walker A motif; other site 373994014262 ATP binding site [chemical binding]; other site 373994014263 Walker B motif; other site 373994014264 arginine finger; other site 373994014265 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 373994014266 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 373994014267 XisH protein; Region: XisH; pfam08814 373994014268 T4 bacteriophage base plate protein; Region: T4_baseplate; pfam12322 373994014269 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 373994014270 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 373994014271 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 373994014272 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 373994014273 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 373994014274 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 373994014275 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 373994014276 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 373994014277 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 373994014278 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 373994014279 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 373994014280 Protein kinase domain; Region: Pkinase; pfam00069 373994014281 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994014282 active site 373994014283 ATP binding site [chemical binding]; other site 373994014284 substrate binding site [chemical binding]; other site 373994014285 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994014286 substrate binding site [chemical binding]; other site 373994014287 activation loop (A-loop); other site 373994014288 activation loop (A-loop); other site 373994014289 AAA ATPase domain; Region: AAA_16; pfam13191 373994014290 Predicted ATPase [General function prediction only]; Region: COG3899 373994014291 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994014292 GAF domain; Region: GAF; pfam01590 373994014293 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994014294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994014295 ATP binding site [chemical binding]; other site 373994014296 Mg2+ binding site [ion binding]; other site 373994014297 G-X-G motif; other site 373994014298 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 373994014299 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 373994014300 Protein of unknown function (DUF554); Region: DUF554; pfam04474 373994014301 Leucine rich repeat; Region: LRR_8; pfam13855 373994014302 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373994014303 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 373994014304 TrkA-N domain; Region: TrkA_N; pfam02254 373994014305 TrkA-N domain; Region: TrkA_N; pfam02254 373994014306 Staphylococcal nuclease homologues; Region: SNc; smart00318 373994014307 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 373994014308 Catalytic site; other site 373994014309 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 373994014310 endoglucanase; Region: PLN02308 373994014311 Cellulose binding domain; Region: CBM_2; pfam00553 373994014312 Cellulose binding domain; Region: CBM_2; pfam00553 373994014313 SseB protein; Region: SseB; cl06279 373994014314 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 373994014315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994014316 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 373994014317 Homeodomain-like domain; Region: HTH_23; pfam13384 373994014318 Winged helix-turn helix; Region: HTH_29; pfam13551 373994014319 Homeodomain-like domain; Region: HTH_32; pfam13565 373994014320 Winged helix-turn helix; Region: HTH_33; pfam13592 373994014321 DDE superfamily endonuclease; Region: DDE_3; pfam13358 373994014322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 373994014323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014324 TPR motif; other site 373994014325 binding surface 373994014326 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 373994014327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014328 binding surface 373994014329 TPR motif; other site 373994014330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014331 binding surface 373994014332 TPR motif; other site 373994014333 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994014334 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014335 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014336 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994014338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994014339 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 373994014340 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 373994014341 putative C-terminal domain interface [polypeptide binding]; other site 373994014342 putative GSH binding site (G-site) [chemical binding]; other site 373994014343 putative dimer interface [polypeptide binding]; other site 373994014344 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 373994014345 putative N-terminal domain interface [polypeptide binding]; other site 373994014346 putative dimer interface [polypeptide binding]; other site 373994014347 putative substrate binding pocket (H-site) [chemical binding]; other site 373994014348 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994014349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994014350 S-adenosylmethionine binding site [chemical binding]; other site 373994014351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994014352 S-adenosylmethionine binding site [chemical binding]; other site 373994014353 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994014354 Cytochrome P450; Region: p450; pfam00067 373994014355 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 373994014356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994014357 non-specific DNA binding site [nucleotide binding]; other site 373994014358 salt bridge; other site 373994014359 sequence-specific DNA binding site [nucleotide binding]; other site 373994014360 AAA ATPase domain; Region: AAA_16; pfam13191 373994014361 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 373994014362 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994014363 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 373994014364 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 373994014365 putative NAD(P) binding site [chemical binding]; other site 373994014366 catalytic Zn binding site [ion binding]; other site 373994014367 structural Zn binding site [ion binding]; other site 373994014368 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994014369 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014370 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014371 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014372 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014373 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014374 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 373994014375 metal binding site 2 [ion binding]; metal-binding site 373994014376 putative DNA binding helix; other site 373994014377 metal binding site 1 [ion binding]; metal-binding site 373994014378 dimer interface [polypeptide binding]; other site 373994014379 structural Zn2+ binding site [ion binding]; other site 373994014380 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 373994014381 catalytic triad [active] 373994014382 dimer interface [polypeptide binding]; other site 373994014383 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 373994014384 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994014385 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 373994014386 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994014387 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 373994014388 Walker A/P-loop; other site 373994014389 ATP binding site [chemical binding]; other site 373994014390 Q-loop/lid; other site 373994014391 ABC transporter signature motif; other site 373994014392 Walker B; other site 373994014393 D-loop; other site 373994014394 H-loop/switch region; other site 373994014395 XisH protein; Region: XisH; pfam08814 373994014396 XisI protein; Region: XisI; pfam08869 373994014397 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 373994014398 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 373994014399 dimer interface [polypeptide binding]; other site 373994014400 active site 373994014401 catalytic residue [active] 373994014402 metal binding site [ion binding]; metal-binding site 373994014403 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 373994014404 Cytochrome c; Region: Cytochrom_C; pfam00034 373994014405 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 373994014406 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 373994014407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994014408 S-adenosylmethionine binding site [chemical binding]; other site 373994014409 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 373994014410 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 373994014411 putative active site [active] 373994014412 oxyanion strand; other site 373994014413 catalytic triad [active] 373994014414 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 373994014415 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373994014416 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 373994014417 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 373994014418 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 373994014419 dimerization interface [polypeptide binding]; other site 373994014420 active site 373994014421 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994014422 putative active site [active] 373994014423 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 373994014424 putative catalytic site [active] 373994014425 putative metal binding site [ion binding]; other site 373994014426 putative phosphate binding site [ion binding]; other site 373994014427 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994014428 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 373994014429 arginine-tRNA ligase; Region: PLN02286 373994014430 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 373994014431 active site 373994014432 HIGH motif; other site 373994014433 KMSK motif region; other site 373994014434 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 373994014435 tRNA binding surface [nucleotide binding]; other site 373994014436 anticodon binding site; other site 373994014437 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 373994014438 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 373994014439 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 373994014440 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 373994014441 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 373994014442 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373994014443 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389 373994014444 AMIN domain; Region: AMIN; pfam11741 373994014445 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 373994014446 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 373994014447 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 373994014448 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 373994014449 tetrameric interface [polypeptide binding]; other site 373994014450 NAD binding site [chemical binding]; other site 373994014451 catalytic residues [active] 373994014452 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 373994014453 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 373994014454 Beta-lactamase; Region: Beta-lactamase; pfam00144 373994014455 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 373994014456 active site 373994014457 catalytic triad [active] 373994014458 oxyanion hole [active] 373994014459 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 373994014460 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 373994014461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373994014462 putative DNA binding site [nucleotide binding]; other site 373994014463 putative Zn2+ binding site [ion binding]; other site 373994014464 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 373994014465 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373994014466 Soluble P-type ATPase [General function prediction only]; Region: COG4087 373994014467 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 373994014468 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 373994014469 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994014470 ligand binding site [chemical binding]; other site 373994014471 flexible hinge region; other site 373994014472 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 373994014473 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 373994014474 putative active site [active] 373994014475 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994014476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994014477 Walker A/P-loop; other site 373994014478 ATP binding site [chemical binding]; other site 373994014479 Q-loop/lid; other site 373994014480 ABC transporter signature motif; other site 373994014481 Walker B; other site 373994014482 D-loop; other site 373994014483 H-loop/switch region; other site 373994014484 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 373994014485 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 373994014486 carboxyltransferase (CT) interaction site; other site 373994014487 biotinylation site [posttranslational modification]; other site 373994014488 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994014489 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 373994014490 metal ion-dependent adhesion site (MIDAS); other site 373994014491 Calx-beta domain; Region: Calx-beta; cl02522 373994014492 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 373994014493 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 373994014494 dimer interface [polypeptide binding]; other site 373994014495 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 373994014496 active site 373994014497 Fe binding site [ion binding]; other site 373994014498 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 373994014499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994014500 motif II; other site 373994014501 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 373994014502 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994014503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994014504 active site 373994014505 phosphorylation site [posttranslational modification] 373994014506 intermolecular recognition site; other site 373994014507 dimerization interface [polypeptide binding]; other site 373994014508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994014509 DNA binding site [nucleotide binding] 373994014510 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 373994014511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994014512 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373994014513 putative substrate translocation pore; other site 373994014514 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 373994014515 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 373994014516 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 373994014517 metal binding site [ion binding]; metal-binding site 373994014518 glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482 373994014519 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 373994014520 inhibitor-cofactor binding pocket; inhibition site 373994014521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994014522 catalytic residue [active] 373994014523 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 373994014524 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994014525 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994014526 active site 373994014527 ATP binding site [chemical binding]; other site 373994014528 substrate binding site [chemical binding]; other site 373994014529 activation loop (A-loop); other site 373994014530 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994014531 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014532 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014533 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 373994014534 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994014535 phosphopeptide binding site; other site 373994014536 recombinase A; Provisional; Region: recA; PRK09354 373994014537 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 373994014538 hexamer interface [polypeptide binding]; other site 373994014539 Walker A motif; other site 373994014540 ATP binding site [chemical binding]; other site 373994014541 Walker B motif; other site 373994014542 adenylate kinase; Provisional; Region: adk; PRK02496 373994014543 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 373994014544 AMP-binding site [chemical binding]; other site 373994014545 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 373994014546 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 373994014547 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 373994014548 trimer interface [polypeptide binding]; other site 373994014549 active site 373994014550 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 373994014551 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 373994014552 putative catalytic residue [active] 373994014553 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 373994014554 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 373994014555 hinge; other site 373994014556 active site 373994014557 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 373994014558 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 373994014559 Walker A/P-loop; other site 373994014560 ATP binding site [chemical binding]; other site 373994014561 Q-loop/lid; other site 373994014562 ABC transporter signature motif; other site 373994014563 Walker B; other site 373994014564 D-loop; other site 373994014565 H-loop/switch region; other site 373994014566 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 373994014567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994014568 dimer interface [polypeptide binding]; other site 373994014569 conserved gate region; other site 373994014570 putative PBP binding loops; other site 373994014571 ABC-ATPase subunit interface; other site 373994014572 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 373994014573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994014574 dimer interface [polypeptide binding]; other site 373994014575 conserved gate region; other site 373994014576 putative PBP binding loops; other site 373994014577 ABC-ATPase subunit interface; other site 373994014578 PBP superfamily domain; Region: PBP_like_2; cl17296 373994014579 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 373994014580 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 373994014581 putative active site [active] 373994014582 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 373994014583 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 373994014584 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373994014585 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 373994014586 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373994014587 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 373994014588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994014589 Coenzyme A binding pocket [chemical binding]; other site 373994014590 agmatinase; Region: agmatinase; TIGR01230 373994014591 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 373994014592 putative active site [active] 373994014593 Mn binding site [ion binding]; other site 373994014594 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 373994014595 threonine dehydratase; Reviewed; Region: PRK09224 373994014596 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 373994014597 tetramer interface [polypeptide binding]; other site 373994014598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994014599 catalytic residue [active] 373994014600 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 373994014601 putative Ile/Val binding site [chemical binding]; other site 373994014602 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 373994014603 putative Ile/Val binding site [chemical binding]; other site 373994014604 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994014605 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994014606 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373994014607 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373994014608 active site 373994014609 catalytic tetrad [active] 373994014610 alpha-glucosidase; Provisional; Region: PRK10137 373994014611 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 373994014612 Cupin domain; Region: Cupin_2; pfam07883 373994014613 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 373994014614 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 373994014615 NADP binding site [chemical binding]; other site 373994014616 homodimer interface [polypeptide binding]; other site 373994014617 active site 373994014618 substrate binding site [chemical binding]; other site 373994014619 Isochorismatase family; Region: Isochorismatase; pfam00857 373994014620 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 373994014621 catalytic triad [active] 373994014622 conserved cis-peptide bond; other site 373994014623 SnoaL-like domain; Region: SnoaL_4; pfam13577 373994014624 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 373994014625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994014626 NAD(P) binding site [chemical binding]; other site 373994014627 active site 373994014628 C factor cell-cell signaling protein; Provisional; Region: PRK09009 373994014629 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 373994014630 NADP binding site [chemical binding]; other site 373994014631 homodimer interface [polypeptide binding]; other site 373994014632 active site 373994014633 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 373994014634 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 373994014635 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 373994014636 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 373994014637 generic binding surface II; other site 373994014638 generic binding surface I; other site 373994014639 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 373994014640 putative active site [active] 373994014641 putative catalytic site [active] 373994014642 putative Mg binding site IVb [ion binding]; other site 373994014643 putative phosphate binding site [ion binding]; other site 373994014644 putative DNA binding site [nucleotide binding]; other site 373994014645 putative Mg binding site IVa [ion binding]; other site 373994014646 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 373994014647 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 373994014648 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 373994014649 putative active site [active] 373994014650 putative metal binding site [ion binding]; other site 373994014651 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 373994014652 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 373994014653 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 373994014654 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 373994014655 salicylate hydroxylase; Provisional; Region: PRK08163 373994014656 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 373994014657 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 373994014658 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 373994014659 Family of unknown function (DUF490); Region: DUF490; pfam04357 373994014660 Family of unknown function (DUF490); Region: DUF490; pfam04357 373994014661 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 373994014662 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 373994014663 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 373994014664 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 373994014665 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 373994014666 Strictosidine synthase; Region: Str_synth; pfam03088 373994014667 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 373994014668 catalytic core [active] 373994014669 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 373994014670 putative cation:proton antiport protein; Provisional; Region: PRK10669 373994014671 TrkA-N domain; Region: TrkA_N; pfam02254 373994014672 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 373994014673 putative dimer interface [polypeptide binding]; other site 373994014674 putative [2Fe-2S] cluster binding site [ion binding]; other site 373994014675 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 373994014676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994014677 motif II; other site 373994014678 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 373994014679 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 373994014680 active site 373994014681 trimer interface [polypeptide binding]; other site 373994014682 allosteric site; other site 373994014683 active site lid [active] 373994014684 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 373994014685 Stage II sporulation protein; Region: SpoIID; pfam08486 373994014686 ribonuclease Z; Region: RNase_Z; TIGR02651 373994014687 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 373994014688 active site 373994014689 ligand binding site [chemical binding]; other site 373994014690 NAD(P) binding site [chemical binding]; other site 373994014691 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 373994014692 Peptidase family M50; Region: Peptidase_M50; pfam02163 373994014693 active site 373994014694 putative substrate binding region [chemical binding]; other site 373994014695 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 373994014696 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 373994014697 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 373994014698 FMN binding site [chemical binding]; other site 373994014699 active site 373994014700 catalytic residues [active] 373994014701 substrate binding site [chemical binding]; other site 373994014702 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 373994014703 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 373994014704 putative dimer interface [polypeptide binding]; other site 373994014705 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 373994014706 homotrimer interface [polypeptide binding]; other site 373994014707 Walker A motif; other site 373994014708 GTP binding site [chemical binding]; other site 373994014709 Walker B motif; other site 373994014710 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994014711 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994014712 active site 373994014713 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994014714 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 373994014715 putative metal binding site; other site 373994014716 putative acyl transferase; Provisional; Region: PRK10502 373994014717 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 373994014718 putative trimer interface [polypeptide binding]; other site 373994014719 putative active site [active] 373994014720 putative substrate binding site [chemical binding]; other site 373994014721 putative CoA binding site [chemical binding]; other site 373994014722 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 373994014723 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 373994014724 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 373994014725 active site 373994014726 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 373994014727 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994014728 Probable transposase; Region: OrfB_IS605; pfam01385 373994014729 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 373994014730 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 373994014731 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 373994014732 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 373994014733 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 373994014734 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 373994014735 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 373994014736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014737 binding surface 373994014738 TPR repeat; Region: TPR_11; pfam13414 373994014739 TPR motif; other site 373994014740 TPR repeat; Region: TPR_11; pfam13414 373994014741 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373994014742 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 373994014743 substrate binding pocket [chemical binding]; other site 373994014744 membrane-bound complex binding site; other site 373994014745 hinge residues; other site 373994014746 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 373994014747 23S rRNA binding site [nucleotide binding]; other site 373994014748 L21 binding site [polypeptide binding]; other site 373994014749 L13 binding site [polypeptide binding]; other site 373994014750 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 373994014751 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 373994014752 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 373994014753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994014754 NAD(P) binding site [chemical binding]; other site 373994014755 active site 373994014756 Response regulator receiver domain; Region: Response_reg; pfam00072 373994014757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994014758 active site 373994014759 phosphorylation site [posttranslational modification] 373994014760 intermolecular recognition site; other site 373994014761 dimerization interface [polypeptide binding]; other site 373994014762 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373994014763 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 373994014764 Moco binding site; other site 373994014765 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 373994014766 metal coordination site [ion binding]; other site 373994014767 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 373994014768 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 373994014769 Adenosylmethionine decarboxylase; Region: SAM_decarbox; cl03253 373994014770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994014771 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994014772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994014773 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 373994014774 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 373994014775 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373994014776 DinB family; Region: DinB; cl17821 373994014777 DinB superfamily; Region: DinB_2; pfam12867 373994014778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 373994014779 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 373994014780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994014781 S-adenosylmethionine binding site [chemical binding]; other site 373994014782 Response regulator receiver domain; Region: Response_reg; pfam00072 373994014783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994014784 active site 373994014785 phosphorylation site [posttranslational modification] 373994014786 intermolecular recognition site; other site 373994014787 dimerization interface [polypeptide binding]; other site 373994014788 GAF domain; Region: GAF; pfam01590 373994014789 GAF domain; Region: GAF_2; pfam13185 373994014790 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 373994014791 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 373994014792 amidase; Provisional; Region: PRK09201 373994014793 Amidase; Region: Amidase; cl11426 373994014794 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 373994014795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 373994014796 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 373994014797 Protein kinase domain; Region: Pkinase; pfam00069 373994014798 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994014799 active site 373994014800 ATP binding site [chemical binding]; other site 373994014801 substrate binding site [chemical binding]; other site 373994014802 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994014803 substrate binding site [chemical binding]; other site 373994014804 activation loop (A-loop); other site 373994014805 activation loop (A-loop); other site 373994014806 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994014807 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994014808 active site 373994014809 ATP binding site [chemical binding]; other site 373994014810 substrate binding site [chemical binding]; other site 373994014811 activation loop (A-loop); other site 373994014812 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 373994014813 ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793 373994014814 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 373994014815 DNA binding site [nucleotide binding] 373994014816 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 373994014817 active site 373994014818 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 373994014819 GAF domain; Region: GAF; pfam01590 373994014820 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994014821 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994014822 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994014823 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994014824 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994014825 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994014826 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994014827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994014828 dimer interface [polypeptide binding]; other site 373994014829 phosphorylation site [posttranslational modification] 373994014830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994014831 ATP binding site [chemical binding]; other site 373994014832 Mg2+ binding site [ion binding]; other site 373994014833 G-X-G motif; other site 373994014834 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994014835 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994014836 structural tetrad; other site 373994014837 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994014838 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994014839 active site 373994014840 ATP binding site [chemical binding]; other site 373994014841 substrate binding site [chemical binding]; other site 373994014842 activation loop (A-loop); other site 373994014843 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994014844 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994014845 structural tetrad; other site 373994014846 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994014847 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994014848 active site 373994014849 ATP binding site [chemical binding]; other site 373994014850 substrate binding site [chemical binding]; other site 373994014851 activation loop (A-loop); other site 373994014852 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 373994014853 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 373994014854 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 373994014855 putative active site [active] 373994014856 catalytic site [active] 373994014857 NifU-like domain; Region: NifU; pfam01106 373994014858 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 373994014859 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 373994014860 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 373994014861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014862 binding surface 373994014863 TPR motif; other site 373994014864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014865 TPR motif; other site 373994014866 binding surface 373994014867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014868 TPR motif; other site 373994014869 binding surface 373994014870 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 373994014871 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 373994014872 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 373994014873 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 373994014874 DXD motif; other site 373994014875 PilZ domain; Region: PilZ; pfam07238 373994014876 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994014877 GAF domain; Region: GAF_3; pfam13492 373994014878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994014879 dimer interface [polypeptide binding]; other site 373994014880 phosphorylation site [posttranslational modification] 373994014881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994014882 ATP binding site [chemical binding]; other site 373994014883 Mg2+ binding site [ion binding]; other site 373994014884 G-X-G motif; other site 373994014885 GTP-binding protein LepA; Provisional; Region: PRK05433 373994014886 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 373994014887 G1 box; other site 373994014888 putative GEF interaction site [polypeptide binding]; other site 373994014889 GTP/Mg2+ binding site [chemical binding]; other site 373994014890 Switch I region; other site 373994014891 G2 box; other site 373994014892 G3 box; other site 373994014893 Switch II region; other site 373994014894 G4 box; other site 373994014895 G5 box; other site 373994014896 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 373994014897 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 373994014898 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 373994014899 endonuclease subunit; Provisional; Region: 46; PHA02562 373994014900 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373994014901 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994014902 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 373994014903 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373994014904 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373994014905 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994014906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994014907 active site 373994014908 phosphorylation site [posttranslational modification] 373994014909 intermolecular recognition site; other site 373994014910 dimerization interface [polypeptide binding]; other site 373994014911 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373994014912 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373994014913 metal binding site [ion binding]; metal-binding site 373994014914 active site 373994014915 I-site; other site 373994014916 GAF domain; Region: GAF; pfam01590 373994014917 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994014918 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994014919 GAF domain; Region: GAF_3; pfam13492 373994014920 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994014921 GAF domain; Region: GAF; pfam01590 373994014922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994014923 dimer interface [polypeptide binding]; other site 373994014924 phosphorylation site [posttranslational modification] 373994014925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994014926 ATP binding site [chemical binding]; other site 373994014927 Mg2+ binding site [ion binding]; other site 373994014928 G-X-G motif; other site 373994014929 Response regulator receiver domain; Region: Response_reg; pfam00072 373994014930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994014931 active site 373994014932 phosphorylation site [posttranslational modification] 373994014933 intermolecular recognition site; other site 373994014934 dimerization interface [polypeptide binding]; other site 373994014935 Response regulator receiver domain; Region: Response_reg; pfam00072 373994014936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994014937 active site 373994014938 phosphorylation site [posttranslational modification] 373994014939 intermolecular recognition site; other site 373994014940 dimerization interface [polypeptide binding]; other site 373994014941 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 373994014942 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 373994014943 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 373994014944 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 373994014945 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373994014946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994014947 active site 373994014948 phosphorylation site [posttranslational modification] 373994014949 intermolecular recognition site; other site 373994014950 dimerization interface [polypeptide binding]; other site 373994014951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373994014952 DNA binding site [nucleotide binding] 373994014953 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 373994014954 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 373994014955 AAA domain; Region: AAA_22; pfam13401 373994014956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994014957 Walker A motif; other site 373994014958 ATP binding site [chemical binding]; other site 373994014959 Walker B motif; other site 373994014960 arginine finger; other site 373994014961 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014963 binding surface 373994014964 TPR motif; other site 373994014965 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014967 binding surface 373994014968 TPR motif; other site 373994014969 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014970 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994014972 binding surface 373994014973 TPR motif; other site 373994014974 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014975 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994014976 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 373994014977 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 373994014978 putative acyl-acceptor binding pocket; other site 373994014979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994014980 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994014981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994014982 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 373994014983 Beta-lactamase; Region: Beta-lactamase; pfam00144 373994014984 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 373994014985 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 373994014986 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 373994014987 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 373994014988 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373994014989 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 373994014990 active site residue [active] 373994014991 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994014992 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994014993 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994014994 structural tetrad; other site 373994014995 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994014996 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994014997 structural tetrad; other site 373994014998 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994014999 structural tetrad; other site 373994015000 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 373994015001 amphipathic channel; other site 373994015002 Asn-Pro-Ala signature motifs; other site 373994015003 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 373994015004 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 373994015005 active site 373994015006 DNA binding site [nucleotide binding] 373994015007 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 373994015008 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 373994015009 Catalytic site [active] 373994015010 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373994015011 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994015012 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994015013 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994015014 ligand binding site [chemical binding]; other site 373994015015 flexible hinge region; other site 373994015016 Cache domain; Region: Cache_1; pfam02743 373994015017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994015018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994015019 dimerization interface [polypeptide binding]; other site 373994015020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994015021 dimer interface [polypeptide binding]; other site 373994015022 phosphorylation site [posttranslational modification] 373994015023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015024 ATP binding site [chemical binding]; other site 373994015025 Mg2+ binding site [ion binding]; other site 373994015026 G-X-G motif; other site 373994015027 Response regulator receiver domain; Region: Response_reg; pfam00072 373994015028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994015029 active site 373994015030 phosphorylation site [posttranslational modification] 373994015031 intermolecular recognition site; other site 373994015032 dimerization interface [polypeptide binding]; other site 373994015033 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 373994015034 cyclase homology domain; Region: CHD; cd07302 373994015035 nucleotidyl binding site; other site 373994015036 metal binding site [ion binding]; metal-binding site 373994015037 dimer interface [polypeptide binding]; other site 373994015038 Cache domain; Region: Cache_1; pfam02743 373994015039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994015040 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994015041 dimerization interface [polypeptide binding]; other site 373994015042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994015043 dimer interface [polypeptide binding]; other site 373994015044 phosphorylation site [posttranslational modification] 373994015045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015046 ATP binding site [chemical binding]; other site 373994015047 Mg2+ binding site [ion binding]; other site 373994015048 G-X-G motif; other site 373994015049 Response regulator receiver domain; Region: Response_reg; pfam00072 373994015050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994015051 active site 373994015052 phosphorylation site [posttranslational modification] 373994015053 intermolecular recognition site; other site 373994015054 dimerization interface [polypeptide binding]; other site 373994015055 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 373994015056 cyclase homology domain; Region: CHD; cd07302 373994015057 nucleotidyl binding site; other site 373994015058 metal binding site [ion binding]; metal-binding site 373994015059 dimer interface [polypeptide binding]; other site 373994015060 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373994015061 Chain length determinant protein; Region: Wzz; pfam02706 373994015062 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 373994015063 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 373994015064 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 373994015065 Nucleotide binding site [chemical binding]; other site 373994015066 DTAP/Switch II; other site 373994015067 Switch I; other site 373994015068 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994015069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994015070 active site 373994015071 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 373994015072 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 373994015073 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 373994015074 O-Antigen ligase; Region: Wzy_C; pfam04932 373994015075 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 373994015076 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994015077 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994015078 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 373994015079 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 373994015080 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 373994015081 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994015082 active site 373994015083 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 373994015084 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 373994015085 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 373994015086 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 373994015087 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 373994015088 Bacterial sugar transferase; Region: Bac_transf; pfam02397 373994015089 MarR family; Region: MarR; pfam01047 373994015090 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 373994015091 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 373994015092 Walker A/P-loop; other site 373994015093 ATP binding site [chemical binding]; other site 373994015094 Q-loop/lid; other site 373994015095 ABC transporter signature motif; other site 373994015096 Walker B; other site 373994015097 D-loop; other site 373994015098 H-loop/switch region; other site 373994015099 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 373994015100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994015101 dimer interface [polypeptide binding]; other site 373994015102 conserved gate region; other site 373994015103 ABC-ATPase subunit interface; other site 373994015104 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 373994015105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994015106 dimer interface [polypeptide binding]; other site 373994015107 conserved gate region; other site 373994015108 putative PBP binding loops; other site 373994015109 ABC-ATPase subunit interface; other site 373994015110 PBP superfamily domain; Region: PBP_like_2; cl17296 373994015111 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 373994015112 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 373994015113 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 373994015114 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 373994015115 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 373994015116 Walker A/P-loop; other site 373994015117 ATP binding site [chemical binding]; other site 373994015118 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 373994015119 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 373994015120 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 373994015121 ABC transporter signature motif; other site 373994015122 Walker B; other site 373994015123 D-loop; other site 373994015124 H-loop/switch region; other site 373994015125 PRC-barrel domain; Region: PRC; pfam05239 373994015126 PRC-barrel domain; Region: PRC; pfam05239 373994015127 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 373994015128 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 373994015129 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 373994015130 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994015131 Cytochrome P450; Region: p450; cl12078 373994015132 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994015133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994015134 S-adenosylmethionine binding site [chemical binding]; other site 373994015135 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 373994015136 active site 373994015137 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 373994015138 active site 373994015139 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 373994015140 dimer interface [polypeptide binding]; other site 373994015141 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 373994015142 Ligand Binding Site [chemical binding]; other site 373994015143 Molecular Tunnel; other site 373994015144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994015145 binding surface 373994015146 TPR motif; other site 373994015147 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 373994015148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994015149 binding surface 373994015150 TPR motif; other site 373994015151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994015152 binding surface 373994015153 TPR motif; other site 373994015154 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 373994015155 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 373994015156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994015157 Walker A motif; other site 373994015158 ATP binding site [chemical binding]; other site 373994015159 Walker B motif; other site 373994015160 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 373994015161 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 373994015162 Fatty acid desaturase; Region: FA_desaturase; pfam00487 373994015163 Di-iron ligands [ion binding]; other site 373994015164 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 373994015165 nucleotide binding site/active site [active] 373994015166 HIT family signature motif; other site 373994015167 catalytic residue [active] 373994015168 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 373994015169 protein I interface; other site 373994015170 D2 interface; other site 373994015171 protein T interface; other site 373994015172 chlorophyll binding site; other site 373994015173 beta carotene binding site; other site 373994015174 pheophytin binding site; other site 373994015175 manganese-stabilizing polypeptide interface; other site 373994015176 CP43 interface; other site 373994015177 protein L interface; other site 373994015178 oxygen evolving complex binding site; other site 373994015179 bromide binding site; other site 373994015180 quinone binding site; other site 373994015181 Fe binding site [ion binding]; other site 373994015182 core light harvesting interface; other site 373994015183 cytochrome b559 alpha subunit interface; other site 373994015184 cytochrome c-550 interface; other site 373994015185 protein J interface; other site 373994015186 S-layer homology domain; Region: SLH; pfam00395 373994015187 S-layer homology domain; Region: SLH; pfam00395 373994015188 recombination protein RecR; Reviewed; Region: recR; PRK00076 373994015189 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 373994015190 RecR protein; Region: RecR; pfam02132 373994015191 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 373994015192 putative active site [active] 373994015193 putative metal-binding site [ion binding]; other site 373994015194 tetramer interface [polypeptide binding]; other site 373994015195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373994015196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994015197 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 373994015198 putative dimerization interface [polypeptide binding]; other site 373994015199 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 373994015200 ABC1 family; Region: ABC1; pfam03109 373994015201 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 373994015202 active site 373994015203 ATP binding site [chemical binding]; other site 373994015204 ABC1 family; Region: ABC1; cl17513 373994015205 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 373994015206 active site 373994015207 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 373994015208 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994015209 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994015210 active site 373994015211 ATP binding site [chemical binding]; other site 373994015212 substrate binding site [chemical binding]; other site 373994015213 activation loop (A-loop); other site 373994015214 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 373994015215 K+-transporting ATPase, c chain; Region: KdpC; cl00944 373994015216 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 373994015217 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373994015218 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 373994015219 PAS domain S-box; Region: sensory_box; TIGR00229 373994015220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994015221 putative active site [active] 373994015222 heme pocket [chemical binding]; other site 373994015223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994015224 dimer interface [polypeptide binding]; other site 373994015225 phosphorylation site [posttranslational modification] 373994015226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015227 ATP binding site [chemical binding]; other site 373994015228 Mg2+ binding site [ion binding]; other site 373994015229 G-X-G motif; other site 373994015230 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994015231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994015232 active site 373994015233 phosphorylation site [posttranslational modification] 373994015234 intermolecular recognition site; other site 373994015235 dimerization interface [polypeptide binding]; other site 373994015236 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 373994015237 tetramer interface [polypeptide binding]; other site 373994015238 dimer interface [polypeptide binding]; other site 373994015239 circadian clock protein KaiC; Reviewed; Region: PRK09302 373994015240 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 373994015241 Walker A motif; other site 373994015242 ATP binding site [chemical binding]; other site 373994015243 Walker B motif; other site 373994015244 recA bacterial DNA recombination protein; Region: RecA; cl17211 373994015245 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 373994015246 Walker A motif; other site 373994015247 ATP binding site [chemical binding]; other site 373994015248 Walker B motif; other site 373994015249 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994015250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994015251 active site 373994015252 phosphorylation site [posttranslational modification] 373994015253 intermolecular recognition site; other site 373994015254 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 373994015255 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994015256 putative active site [active] 373994015257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994015258 dimer interface [polypeptide binding]; other site 373994015259 phosphorylation site [posttranslational modification] 373994015260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015261 ATP binding site [chemical binding]; other site 373994015262 Mg2+ binding site [ion binding]; other site 373994015263 G-X-G motif; other site 373994015264 Response regulator receiver domain; Region: Response_reg; pfam00072 373994015265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994015266 active site 373994015267 phosphorylation site [posttranslational modification] 373994015268 intermolecular recognition site; other site 373994015269 dimerization interface [polypeptide binding]; other site 373994015270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994015271 primosomal protein N' Region: priA; TIGR00595 373994015272 ATP binding site [chemical binding]; other site 373994015273 putative Mg++ binding site [ion binding]; other site 373994015274 helicase superfamily c-terminal domain; Region: HELICc; smart00490 373994015275 ATP-binding site [chemical binding]; other site 373994015276 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 373994015277 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 373994015278 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373994015279 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373994015280 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373994015281 DNA binding residues [nucleotide binding] 373994015282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373994015283 Coenzyme A binding pocket [chemical binding]; other site 373994015284 Cytochrome c; Region: Cytochrom_C; cl11414 373994015285 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 373994015286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994015287 binding surface 373994015288 TPR repeat; Region: TPR_11; pfam13414 373994015289 TPR motif; other site 373994015290 TPR repeat; Region: TPR_11; pfam13414 373994015291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994015292 binding surface 373994015293 TPR motif; other site 373994015294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994015295 binding surface 373994015296 TPR repeat; Region: TPR_11; pfam13414 373994015297 TPR motif; other site 373994015298 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 373994015299 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 373994015300 active site 373994015301 Na/Ca binding site [ion binding]; other site 373994015302 catalytic site [active] 373994015303 Response regulator receiver domain; Region: Response_reg; pfam00072 373994015304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994015305 active site 373994015306 phosphorylation site [posttranslational modification] 373994015307 intermolecular recognition site; other site 373994015308 dimerization interface [polypeptide binding]; other site 373994015309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015310 ATP binding site [chemical binding]; other site 373994015311 Mg2+ binding site [ion binding]; other site 373994015312 G-X-G motif; other site 373994015313 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994015314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994015315 dimer interface [polypeptide binding]; other site 373994015316 phosphorylation site [posttranslational modification] 373994015317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015318 ATP binding site [chemical binding]; other site 373994015319 Mg2+ binding site [ion binding]; other site 373994015320 G-X-G motif; other site 373994015321 Response regulator receiver domain; Region: Response_reg; pfam00072 373994015322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994015323 active site 373994015324 phosphorylation site [posttranslational modification] 373994015325 intermolecular recognition site; other site 373994015326 dimerization interface [polypeptide binding]; other site 373994015327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 373994015328 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 373994015329 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 373994015330 Probable transposase; Region: OrfB_IS605; pfam01385 373994015331 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 373994015332 LabA_like proteins; Region: LabA_like/DUF88; cl10034 373994015333 putative metal binding site [ion binding]; other site 373994015334 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 373994015335 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 373994015336 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 373994015337 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 373994015338 spermidine synthase; Provisional; Region: PRK00811 373994015339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994015340 S-adenosylmethionine binding site [chemical binding]; other site 373994015341 Phospholipid methyltransferase; Region: PEMT; cl17370 373994015342 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 373994015343 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 373994015344 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 373994015345 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 373994015346 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 373994015347 putative NAD(P) binding site [chemical binding]; other site 373994015348 active site 373994015349 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 373994015350 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 373994015351 hydrophobic ligand binding site; other site 373994015352 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 373994015353 Predicted transcriptional regulator [Transcription]; Region: COG3682 373994015354 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 373994015355 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 373994015356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373994015357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994015358 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 373994015359 putative effector binding pocket; other site 373994015360 dimerization interface [polypeptide binding]; other site 373994015361 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 373994015362 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 373994015363 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 373994015364 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 373994015365 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 373994015366 Zn binding site [ion binding]; other site 373994015367 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 373994015368 protein binding site [polypeptide binding]; other site 373994015369 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994015370 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994015371 ligand binding site [chemical binding]; other site 373994015372 flexible hinge region; other site 373994015373 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 373994015374 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 373994015375 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 373994015376 Hexamer interface [polypeptide binding]; other site 373994015377 Hexagonal pore residue; other site 373994015378 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 373994015379 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 373994015380 Hexamer interface [polypeptide binding]; other site 373994015381 Hexagonal pore residue; other site 373994015382 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 373994015383 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 373994015384 Ligand binding site; other site 373994015385 metal-binding site 373994015386 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 373994015387 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 373994015388 XdhC Rossmann domain; Region: XdhC_C; pfam13478 373994015389 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 373994015390 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 373994015391 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 373994015392 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 373994015393 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 373994015394 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 373994015395 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994015396 catalytic loop [active] 373994015397 iron binding site [ion binding]; other site 373994015398 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 373994015399 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 373994015400 MgtE intracellular N domain; Region: MgtE_N; smart00924 373994015401 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 373994015402 Divalent cation transporter; Region: MgtE; pfam01769 373994015403 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 373994015404 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994015405 active site 373994015406 ATP binding site [chemical binding]; other site 373994015407 substrate binding site [chemical binding]; other site 373994015408 activation loop (A-loop); other site 373994015409 Predicted permeases [General function prediction only]; Region: COG0730 373994015410 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994015411 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994015412 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994015413 Protein of unknown function (DUF504); Region: DUF504; pfam04457 373994015414 Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080 373994015415 putative catalytic site [active] 373994015416 putative metal binding site [ion binding]; other site 373994015417 putative phosphate binding site [ion binding]; other site 373994015418 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 373994015419 Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Region: NT_PAP_TUTase; cd05402 373994015420 Poly(A) polymerase central domain; Region: PAP_central; pfam04928 373994015421 active site 373994015422 metal binding triad [ion binding]; metal-binding site 373994015423 putative primer-binding pocket; other site 373994015424 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373994015425 Zn2+ binding site [ion binding]; other site 373994015426 Mg2+ binding site [ion binding]; other site 373994015427 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 373994015428 AAA domain; Region: AAA_33; pfam13671 373994015429 active site 373994015430 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 373994015431 Predicted coiled-coil domain-containing protein (DUF2360); Region: DUF2360; pfam10152 373994015432 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 373994015433 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 373994015434 metal binding site [ion binding]; metal-binding site 373994015435 dimer interface [polypeptide binding]; other site 373994015436 Peptidase family M23; Region: Peptidase_M23; pfam01551 373994015437 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 373994015438 DoxX; Region: DoxX; pfam07681 373994015439 Predicted membrane protein [Function unknown]; Region: COG2259 373994015440 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 373994015441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994015442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994015443 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994015444 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994015445 putative active site [active] 373994015446 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 373994015447 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994015448 phosphopeptide binding site; other site 373994015449 Protein of unknown function (DUF423); Region: DUF423; cl01008 373994015450 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994015451 dimerization interface [polypeptide binding]; other site 373994015452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015453 ATP binding site [chemical binding]; other site 373994015454 Mg2+ binding site [ion binding]; other site 373994015455 G-X-G motif; other site 373994015456 NurA domain; Region: NurA; pfam09376 373994015457 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 373994015458 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 373994015459 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 373994015460 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 373994015461 Na binding site [ion binding]; other site 373994015462 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994015463 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994015464 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994015465 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994015466 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994015467 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994015468 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994015469 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994015470 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994015471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994015472 binding surface 373994015473 TPR motif; other site 373994015474 TPR repeat; Region: TPR_11; pfam13414 373994015475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994015476 binding surface 373994015477 TPR motif; other site 373994015478 TPR repeat; Region: TPR_11; pfam13414 373994015479 TPR repeat; Region: TPR_11; pfam13414 373994015480 TPR repeat; Region: TPR_11; pfam13414 373994015481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994015482 binding surface 373994015483 TPR motif; other site 373994015484 TPR repeat; Region: TPR_11; pfam13414 373994015485 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 373994015486 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 373994015487 cofactor binding site; other site 373994015488 DNA binding site [nucleotide binding] 373994015489 substrate interaction site [chemical binding]; other site 373994015490 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 373994015491 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 373994015492 PAS fold; Region: PAS_3; pfam08447 373994015493 putative active site [active] 373994015494 heme pocket [chemical binding]; other site 373994015495 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994015496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 373994015497 putative active site [active] 373994015498 heme pocket [chemical binding]; other site 373994015499 PAS domain; Region: PAS_8; pfam13188 373994015500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994015501 dimer interface [polypeptide binding]; other site 373994015502 phosphorylation site [posttranslational modification] 373994015503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015504 ATP binding site [chemical binding]; other site 373994015505 Mg2+ binding site [ion binding]; other site 373994015506 G-X-G motif; other site 373994015507 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 373994015508 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 373994015509 G1 box; other site 373994015510 GTP/Mg2+ binding site [chemical binding]; other site 373994015511 Switch I region; other site 373994015512 G2 box; other site 373994015513 Switch II region; other site 373994015514 G3 box; other site 373994015515 G4 box; other site 373994015516 G5 box; other site 373994015517 Domain of unknown function (DUF697); Region: DUF697; pfam05128 373994015518 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 373994015519 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 373994015520 NAD(P) binding site [chemical binding]; other site 373994015521 short chain dehydrogenase; Provisional; Region: PRK06172 373994015522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994015523 NAD(P) binding site [chemical binding]; other site 373994015524 active site 373994015525 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 373994015526 YCII-related domain; Region: YCII; cl00999 373994015527 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 373994015528 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994015529 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994015530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994015531 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 373994015532 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 373994015533 trimerization site [polypeptide binding]; other site 373994015534 active site 373994015535 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 373994015536 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 373994015537 mercuric reductase; Validated; Region: PRK06370 373994015538 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994015539 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 373994015540 Uncharacterized conserved protein [Function unknown]; Region: COG0398 373994015541 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 373994015542 Uncharacterized conserved protein [Function unknown]; Region: COG0398 373994015543 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 373994015544 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 373994015545 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 373994015546 Probable Catalytic site; other site 373994015547 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994015548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994015549 active site 373994015550 phosphorylation site [posttranslational modification] 373994015551 intermolecular recognition site; other site 373994015552 dimerization interface [polypeptide binding]; other site 373994015553 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994015554 DNA binding residues [nucleotide binding] 373994015555 dimerization interface [polypeptide binding]; other site 373994015556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 373994015557 Histidine kinase; Region: HisKA_3; pfam07730 373994015558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015559 ATP binding site [chemical binding]; other site 373994015560 Mg2+ binding site [ion binding]; other site 373994015561 G-X-G motif; other site 373994015562 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994015563 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 373994015564 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994015565 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994015566 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 373994015567 FtsX-like permease family; Region: FtsX; pfam02687 373994015568 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 373994015569 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 373994015570 Walker A/P-loop; other site 373994015571 ATP binding site [chemical binding]; other site 373994015572 Q-loop/lid; other site 373994015573 ABC transporter signature motif; other site 373994015574 Walker B; other site 373994015575 D-loop; other site 373994015576 H-loop/switch region; other site 373994015577 MarR family; Region: MarR_2; pfam12802 373994015578 MarR family; Region: MarR_2; cl17246 373994015579 phytoene desaturase; Region: crtI_fam; TIGR02734 373994015580 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994015581 hydroxyglutarate oxidase; Provisional; Region: PRK11728 373994015582 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 373994015583 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 373994015584 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 373994015585 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 373994015586 Walker A/P-loop; other site 373994015587 ATP binding site [chemical binding]; other site 373994015588 Q-loop/lid; other site 373994015589 ABC transporter signature motif; other site 373994015590 Walker B; other site 373994015591 D-loop; other site 373994015592 H-loop/switch region; other site 373994015593 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 373994015594 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 373994015595 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994015596 CHAT domain; Region: CHAT; cl17868 373994015597 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994015598 CHASE2 domain; Region: CHASE2; pfam05226 373994015599 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994015600 phosphopeptide binding site; other site 373994015601 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 373994015602 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 373994015603 FAD binding pocket [chemical binding]; other site 373994015604 FAD binding motif [chemical binding]; other site 373994015605 phosphate binding motif [ion binding]; other site 373994015606 beta-alpha-beta structure motif; other site 373994015607 NAD binding pocket [chemical binding]; other site 373994015608 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994015609 catalytic loop [active] 373994015610 iron binding site [ion binding]; other site 373994015611 4Fe-4S binding domain; Region: Fer4_5; pfam12801 373994015612 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994015613 Homeodomain-like domain; Region: HTH_23; pfam13384 373994015614 Winged helix-turn helix; Region: HTH_29; pfam13551 373994015615 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994015616 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994015617 TPR repeat; Region: TPR_11; pfam13414 373994015618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994015619 binding surface 373994015620 TPR motif; other site 373994015621 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994015622 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994015623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 373994015624 YacP-like NYN domain; Region: NYN_YacP; cl01491 373994015625 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 373994015626 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 373994015627 Walker A/P-loop; other site 373994015628 ATP binding site [chemical binding]; other site 373994015629 Q-loop/lid; other site 373994015630 ABC transporter signature motif; other site 373994015631 Walker B; other site 373994015632 D-loop; other site 373994015633 H-loop/switch region; other site 373994015634 hypothetical protein; Provisional; Region: PRK13683 373994015635 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 373994015636 D1 interface; other site 373994015637 chlorophyll binding site; other site 373994015638 pheophytin binding site; other site 373994015639 beta carotene binding site; other site 373994015640 cytochrome b559 beta interface; other site 373994015641 quinone binding site; other site 373994015642 cytochrome b559 alpha interface; other site 373994015643 protein J interface; other site 373994015644 protein H interface; other site 373994015645 protein X interface; other site 373994015646 core light harvesting protein interface; other site 373994015647 protein L interface; other site 373994015648 CP43 interface; other site 373994015649 protein T interface; other site 373994015650 Fe binding site [ion binding]; other site 373994015651 protein M interface; other site 373994015652 Mn-stabilizing polypeptide interface; other site 373994015653 bromide binding site; other site 373994015654 cytochrome c-550 interface; other site 373994015655 S-layer homology domain; Region: SLH; pfam00395 373994015656 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 373994015657 Predicted transcriptional regulator [Transcription]; Region: COG1959 373994015658 Transcriptional regulator; Region: Rrf2; pfam02082 373994015659 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 373994015660 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 373994015661 dimer interface [polypeptide binding]; other site 373994015662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994015663 catalytic residue [active] 373994015664 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373994015665 HSP70 interaction site [polypeptide binding]; other site 373994015666 Response regulator receiver domain; Region: Response_reg; pfam00072 373994015667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994015668 active site 373994015669 phosphorylation site [posttranslational modification] 373994015670 intermolecular recognition site; other site 373994015671 dimerization interface [polypeptide binding]; other site 373994015672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994015673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994015674 dimer interface [polypeptide binding]; other site 373994015675 phosphorylation site [posttranslational modification] 373994015676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015677 ATP binding site [chemical binding]; other site 373994015678 Mg2+ binding site [ion binding]; other site 373994015679 G-X-G motif; other site 373994015680 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 373994015681 active site 373994015682 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 373994015683 active site 373994015684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994015685 S-adenosylmethionine binding site [chemical binding]; other site 373994015686 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 373994015687 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 373994015688 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 373994015689 Zn binding site [ion binding]; other site 373994015690 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 373994015691 DNA binding residues [nucleotide binding] 373994015692 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994015693 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373994015694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994015695 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373994015696 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373994015697 Chain length determinant protein; Region: Wzz; pfam02706 373994015698 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 373994015699 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 373994015700 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994015701 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 373994015702 O-Antigen ligase; Region: Wzy_C; pfam04932 373994015703 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994015704 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 373994015705 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994015706 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994015707 active site 373994015708 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 373994015709 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994015710 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 373994015711 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994015712 active site 373994015713 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 373994015714 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 373994015715 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 373994015716 ABC1 family; Region: ABC1; cl17513 373994015717 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994015718 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 373994015719 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994015720 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994015721 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 373994015722 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994015723 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 373994015724 Walker A/P-loop; other site 373994015725 ATP binding site [chemical binding]; other site 373994015726 Q-loop/lid; other site 373994015727 ABC transporter signature motif; other site 373994015728 Walker B; other site 373994015729 D-loop; other site 373994015730 H-loop/switch region; other site 373994015731 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994015732 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994015733 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 373994015734 Spondin_N; Region: Spond_N; pfam06468 373994015735 CHRD domain; Region: CHRD; pfam07452 373994015736 Spondin_N; Region: Spond_N; pfam06468 373994015737 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 373994015738 DNA protecting protein DprA; Region: dprA; TIGR00732 373994015739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 373994015740 Probable transposase; Region: OrfB_IS605; pfam01385 373994015741 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994015742 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 373994015743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994015744 PAS domain; Region: PAS_9; pfam13426 373994015745 putative active site [active] 373994015746 heme pocket [chemical binding]; other site 373994015747 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994015748 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994015749 PAS domain S-box; Region: sensory_box; TIGR00229 373994015750 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994015751 putative active site [active] 373994015752 heme pocket [chemical binding]; other site 373994015753 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 373994015754 cyclase homology domain; Region: CHD; cd07302 373994015755 nucleotidyl binding site; other site 373994015756 metal binding site [ion binding]; metal-binding site 373994015757 dimer interface [polypeptide binding]; other site 373994015758 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 373994015759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994015760 NAD(P) binding site [chemical binding]; other site 373994015761 active site 373994015762 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 373994015763 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 373994015764 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 373994015765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015766 ATP binding site [chemical binding]; other site 373994015767 Mg2+ binding site [ion binding]; other site 373994015768 G-X-G motif; other site 373994015769 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994015770 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994015771 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994015772 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994015773 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994015774 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994015775 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994015776 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994015777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994015778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994015779 dimer interface [polypeptide binding]; other site 373994015780 phosphorylation site [posttranslational modification] 373994015781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015782 ATP binding site [chemical binding]; other site 373994015783 Mg2+ binding site [ion binding]; other site 373994015784 G-X-G motif; other site 373994015785 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 373994015786 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 373994015787 C-terminal domain interface [polypeptide binding]; other site 373994015788 GSH binding site (G-site) [chemical binding]; other site 373994015789 dimer interface [polypeptide binding]; other site 373994015790 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 373994015791 N-terminal domain interface [polypeptide binding]; other site 373994015792 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 373994015793 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 373994015794 iron-sulfur cluster [ion binding]; other site 373994015795 [2Fe-2S] cluster binding site [ion binding]; other site 373994015796 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 373994015797 hydrophobic ligand binding site; other site 373994015798 CheB methylesterase; Region: CheB_methylest; pfam01339 373994015799 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 373994015800 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 373994015801 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 373994015802 PAS domain; Region: PAS_10; pfam13596 373994015803 PAS fold; Region: PAS_4; pfam08448 373994015804 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994015805 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994015806 dimer interface [polypeptide binding]; other site 373994015807 phosphorylation site [posttranslational modification] 373994015808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015809 ATP binding site [chemical binding]; other site 373994015810 Mg2+ binding site [ion binding]; other site 373994015811 G-X-G motif; other site 373994015812 Response regulator receiver domain; Region: Response_reg; pfam00072 373994015813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994015814 active site 373994015815 phosphorylation site [posttranslational modification] 373994015816 intermolecular recognition site; other site 373994015817 dimerization interface [polypeptide binding]; other site 373994015818 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 373994015819 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 373994015820 NAD(P) binding site [chemical binding]; other site 373994015821 catalytic residues [active] 373994015822 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 373994015823 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 373994015824 dimer interface [polypeptide binding]; other site 373994015825 motif 1; other site 373994015826 active site 373994015827 motif 2; other site 373994015828 motif 3; other site 373994015829 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 373994015830 anticodon binding site; other site 373994015831 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 373994015832 ATP-grasp domain; Region: ATP-grasp_4; cl17255 373994015833 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 373994015834 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 373994015835 active site 373994015836 zinc binding site [ion binding]; other site 373994015837 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994015838 AAA ATPase domain; Region: AAA_16; pfam13191 373994015839 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 373994015840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994015841 Walker A motif; other site 373994015842 ATP binding site [chemical binding]; other site 373994015843 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 373994015844 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 373994015845 NAD(P) binding site [chemical binding]; other site 373994015846 catalytic residues [active] 373994015847 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 373994015848 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 373994015849 homotrimer interaction site [polypeptide binding]; other site 373994015850 putative active site [active] 373994015851 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373994015852 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 373994015853 putative NAD(P) binding site [chemical binding]; other site 373994015854 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994015855 dimerization interface [polypeptide binding]; other site 373994015856 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994015857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994015858 dimer interface [polypeptide binding]; other site 373994015859 phosphorylation site [posttranslational modification] 373994015860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015861 ATP binding site [chemical binding]; other site 373994015862 Mg2+ binding site [ion binding]; other site 373994015863 G-X-G motif; other site 373994015864 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994015865 CHASE2 domain; Region: CHASE2; pfam05226 373994015866 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994015867 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994015868 active site 373994015869 ATP binding site [chemical binding]; other site 373994015870 substrate binding site [chemical binding]; other site 373994015871 activation loop (A-loop); other site 373994015872 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 373994015873 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 373994015874 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994015875 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373994015876 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 373994015877 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 373994015878 RNA binding site [nucleotide binding]; other site 373994015879 active site 373994015880 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 373994015881 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994015882 active site 373994015883 metal binding site [ion binding]; metal-binding site 373994015884 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373994015885 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994015886 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 373994015887 diaminopimelate epimerase; Region: PLN02536 373994015888 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 373994015889 Sm and related proteins; Region: Sm_like; cl00259 373994015890 heptamer interface [polypeptide binding]; other site 373994015891 Sm1 motif; other site 373994015892 hexamer interface [polypeptide binding]; other site 373994015893 RNA binding site [nucleotide binding]; other site 373994015894 Sm2 motif; other site 373994015895 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 373994015896 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 373994015897 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 373994015898 TrkA-N domain; Region: TrkA_N; pfam02254 373994015899 TrkA-C domain; Region: TrkA_C; pfam02080 373994015900 TrkA-C domain; Region: TrkA_C; pfam02080 373994015901 PAS domain; Region: PAS_9; pfam13426 373994015902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994015903 putative active site [active] 373994015904 heme pocket [chemical binding]; other site 373994015905 PAS domain S-box; Region: sensory_box; TIGR00229 373994015906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994015907 putative active site [active] 373994015908 heme pocket [chemical binding]; other site 373994015909 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994015910 PAS fold; Region: PAS_3; pfam08447 373994015911 putative active site [active] 373994015912 heme pocket [chemical binding]; other site 373994015913 PAS fold; Region: PAS_4; pfam08448 373994015914 PAS domain; Region: PAS; smart00091 373994015915 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 373994015916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994015917 dimer interface [polypeptide binding]; other site 373994015918 phosphorylation site [posttranslational modification] 373994015919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015920 ATP binding site [chemical binding]; other site 373994015921 Mg2+ binding site [ion binding]; other site 373994015922 G-X-G motif; other site 373994015923 DNA photolyase; Region: DNA_photolyase; pfam00875 373994015924 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 373994015925 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373994015926 RNA binding surface [nucleotide binding]; other site 373994015927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994015928 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994015929 phosphorylation site [posttranslational modification] 373994015930 intermolecular recognition site; other site 373994015931 PAS domain S-box; Region: sensory_box; TIGR00229 373994015932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994015933 putative active site [active] 373994015934 heme pocket [chemical binding]; other site 373994015935 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994015936 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 373994015937 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994015938 putative active site [active] 373994015939 heme pocket [chemical binding]; other site 373994015940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994015941 dimer interface [polypeptide binding]; other site 373994015942 phosphorylation site [posttranslational modification] 373994015943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994015944 ATP binding site [chemical binding]; other site 373994015945 Mg2+ binding site [ion binding]; other site 373994015946 G-X-G motif; other site 373994015947 Response regulator receiver domain; Region: Response_reg; pfam00072 373994015948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994015949 active site 373994015950 phosphorylation site [posttranslational modification] 373994015951 intermolecular recognition site; other site 373994015952 dimerization interface [polypeptide binding]; other site 373994015953 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 373994015954 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 373994015955 cobalamin binding residues [chemical binding]; other site 373994015956 putative BtuC binding residues; other site 373994015957 dimer interface [polypeptide binding]; other site 373994015958 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 373994015959 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 373994015960 active site 373994015961 Zn binding site [ion binding]; other site 373994015962 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994015963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994015964 S-adenosylmethionine binding site [chemical binding]; other site 373994015965 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373994015966 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994015967 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373994015968 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373994015969 active site 373994015970 catalytic tetrad [active] 373994015971 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 373994015972 murein hydrolase B; Provisional; Region: PRK10760; cl17906 373994015973 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 373994015974 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 373994015975 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373994015976 Zn2+ binding site [ion binding]; other site 373994015977 Mg2+ binding site [ion binding]; other site 373994015978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994015979 NAD(P) binding site [chemical binding]; other site 373994015980 short chain dehydrogenase; Provisional; Region: PRK06914 373994015981 active site 373994015982 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 373994015983 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 373994015984 Ligand Binding Site [chemical binding]; other site 373994015985 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 373994015986 putative metal binding site [ion binding]; other site 373994015987 Response regulator receiver domain; Region: Response_reg; pfam00072 373994015988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994015989 active site 373994015990 phosphorylation site [posttranslational modification] 373994015991 intermolecular recognition site; other site 373994015992 dimerization interface [polypeptide binding]; other site 373994015993 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994015994 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994015995 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373994015996 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373994015997 metal binding site [ion binding]; metal-binding site 373994015998 active site 373994015999 I-site; other site 373994016000 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373994016001 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 373994016002 CheB methylesterase; Region: CheB_methylest; pfam01339 373994016003 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 373994016004 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 373994016005 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 373994016006 PAS domain; Region: PAS_10; pfam13596 373994016007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994016008 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994016009 putative active site [active] 373994016010 heme pocket [chemical binding]; other site 373994016011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994016012 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 373994016013 putative active site [active] 373994016014 heme pocket [chemical binding]; other site 373994016015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994016016 putative active site [active] 373994016017 heme pocket [chemical binding]; other site 373994016018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994016019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994016020 dimer interface [polypeptide binding]; other site 373994016021 phosphorylation site [posttranslational modification] 373994016022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994016023 ATP binding site [chemical binding]; other site 373994016024 Mg2+ binding site [ion binding]; other site 373994016025 G-X-G motif; other site 373994016026 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994016027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994016028 active site 373994016029 phosphorylation site [posttranslational modification] 373994016030 intermolecular recognition site; other site 373994016031 dimerization interface [polypeptide binding]; other site 373994016032 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 373994016033 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373994016034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994016035 homodimer interface [polypeptide binding]; other site 373994016036 catalytic residue [active] 373994016037 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 373994016038 active site 373994016039 NTP binding site [chemical binding]; other site 373994016040 metal binding triad [ion binding]; metal-binding site 373994016041 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994016042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994016043 S-adenosylmethionine binding site [chemical binding]; other site 373994016044 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 373994016045 dimer interface [polypeptide binding]; other site 373994016046 hexamer interface [polypeptide binding]; other site 373994016047 active site 2 [active] 373994016048 heat shock protein HtpX; Provisional; Region: PRK03982 373994016049 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 373994016050 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 373994016051 dimer interface [polypeptide binding]; other site 373994016052 anticodon binding site; other site 373994016053 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 373994016054 homodimer interface [polypeptide binding]; other site 373994016055 motif 1; other site 373994016056 active site 373994016057 motif 2; other site 373994016058 GAD domain; Region: GAD; pfam02938 373994016059 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 373994016060 motif 3; other site 373994016061 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373994016062 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 373994016063 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 373994016064 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 373994016065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994016066 active site 373994016067 Core-2/I-Branching enzyme; Region: Branch; pfam02485 373994016068 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994016069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994016070 active site 373994016071 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994016072 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 373994016073 active site 373994016074 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 373994016075 anti sigma factor interaction site; other site 373994016076 regulatory phosphorylation site [posttranslational modification]; other site 373994016077 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 373994016078 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 373994016079 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 373994016080 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 373994016081 Bacterial sugar transferase; Region: Bac_transf; pfam02397 373994016082 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 373994016083 putative trimer interface [polypeptide binding]; other site 373994016084 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 373994016085 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 373994016086 trimer interface [polypeptide binding]; other site 373994016087 active site 373994016088 substrate binding site [chemical binding]; other site 373994016089 putative CoA binding site [chemical binding]; other site 373994016090 CoA binding site [chemical binding]; other site 373994016091 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 373994016092 putative ADP-binding pocket [chemical binding]; other site 373994016093 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994016094 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 373994016095 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 373994016096 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373994016097 putative active site [active] 373994016098 putative metal binding site [ion binding]; other site 373994016099 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 373994016100 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 373994016101 putative active site pocket [active] 373994016102 dimerization interface [polypeptide binding]; other site 373994016103 putative catalytic residue [active] 373994016104 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 373994016105 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 373994016106 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 373994016107 UbiA prenyltransferase family; Region: UbiA; pfam01040 373994016108 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 373994016109 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 373994016110 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994016111 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 373994016112 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 373994016113 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 373994016114 catalytic residues [active] 373994016115 Uncharacterized conserved protein [Function unknown]; Region: COG3391 373994016116 NHL repeat; Region: NHL; pfam01436 373994016117 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 373994016118 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 373994016119 Domain of unknown function DUF87; Region: DUF87; pfam01935 373994016120 HerA helicase [Replication, recombination, and repair]; Region: COG0433 373994016121 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 373994016122 DNA methylase; Region: N6_N4_Mtase; pfam01555 373994016123 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 373994016124 active site 373994016125 catalytic triad [active] 373994016126 oxyanion hole [active] 373994016127 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994016128 active site 373994016129 ATP binding site [chemical binding]; other site 373994016130 substrate binding site [chemical binding]; other site 373994016131 activation loop (A-loop); other site 373994016132 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 373994016133 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 373994016134 Surface antigen; Region: Bac_surface_Ag; pfam01103 373994016135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 373994016136 conserved hypothetical protein; Region: TIGR03492 373994016137 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 373994016138 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 373994016139 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994016140 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994016141 active site 373994016142 ATP binding site [chemical binding]; other site 373994016143 substrate binding site [chemical binding]; other site 373994016144 activation loop (A-loop); other site 373994016145 Circadian oscillating protein COP23; Region: COP23; pfam14218 373994016146 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994016147 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 373994016148 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994016149 TPR repeat; Region: TPR_11; pfam13414 373994016150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016151 binding surface 373994016152 TPR motif; other site 373994016153 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 373994016154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016155 TPR motif; other site 373994016156 binding surface 373994016157 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016158 binding surface 373994016159 TPR motif; other site 373994016160 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 373994016161 protein binding site [polypeptide binding]; other site 373994016162 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 373994016163 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 373994016164 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 373994016165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 373994016166 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994016167 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994016168 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994016169 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994016170 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994016171 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 373994016172 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 373994016173 active site 373994016174 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 373994016175 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 373994016176 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 373994016177 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 373994016178 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 373994016179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994016180 motif II; other site 373994016181 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 373994016182 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 373994016183 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 373994016184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373994016185 catalytic residue [active] 373994016186 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 373994016187 active site 373994016188 putative DNA-binding cleft [nucleotide binding]; other site 373994016189 dimer interface [polypeptide binding]; other site 373994016190 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 373994016191 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 373994016192 phosphate binding site [ion binding]; other site 373994016193 putative substrate binding pocket [chemical binding]; other site 373994016194 dimer interface [polypeptide binding]; other site 373994016195 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 373994016196 dihydroorotase; Provisional; Region: PRK07575 373994016197 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 373994016198 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 373994016199 active site 373994016200 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 373994016201 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 373994016202 Catalytic site [active] 373994016203 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 373994016204 Response regulator receiver domain; Region: Response_reg; pfam00072 373994016205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994016206 active site 373994016207 phosphorylation site [posttranslational modification] 373994016208 intermolecular recognition site; other site 373994016209 dimerization interface [polypeptide binding]; other site 373994016210 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373994016211 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373994016212 metal binding site [ion binding]; metal-binding site 373994016213 active site 373994016214 I-site; other site 373994016215 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373994016216 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 373994016217 4Fe-4S binding domain; Region: Fer4_6; pfam12837 373994016218 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 373994016219 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 373994016220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994016221 Walker A motif; other site 373994016222 ATP binding site [chemical binding]; other site 373994016223 Walker B motif; other site 373994016224 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 373994016225 RxxxH motif; other site 373994016226 NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521 373994016227 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 373994016228 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 373994016229 cofactor binding site; other site 373994016230 DNA binding site [nucleotide binding] 373994016231 substrate interaction site [chemical binding]; other site 373994016232 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 373994016233 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 373994016234 active site 373994016235 hydrophilic channel; other site 373994016236 dimerization interface [polypeptide binding]; other site 373994016237 catalytic residues [active] 373994016238 active site lid [active] 373994016239 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 373994016240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373994016241 DNA-binding site [nucleotide binding]; DNA binding site 373994016242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373994016243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994016244 homodimer interface [polypeptide binding]; other site 373994016245 catalytic residue [active] 373994016246 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 373994016247 EamA-like transporter family; Region: EamA; pfam00892 373994016248 EamA-like transporter family; Region: EamA; pfam00892 373994016249 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 373994016250 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 373994016251 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 373994016252 TraM protein; Region: Tra_M; cl11621 373994016253 tellurium resistance terB-like protein; Region: terB_like; cd07177 373994016254 metal binding site [ion binding]; metal-binding site 373994016255 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 373994016256 GTPase CgtA; Reviewed; Region: obgE; PRK12299 373994016257 GTP1/OBG; Region: GTP1_OBG; pfam01018 373994016258 Obg GTPase; Region: Obg; cd01898 373994016259 G1 box; other site 373994016260 GTP/Mg2+ binding site [chemical binding]; other site 373994016261 Switch I region; other site 373994016262 G2 box; other site 373994016263 G3 box; other site 373994016264 Switch II region; other site 373994016265 G4 box; other site 373994016266 G5 box; other site 373994016267 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 373994016268 dimer interface [polypeptide binding]; other site 373994016269 catalytic triad [active] 373994016270 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 373994016271 putative ADP-binding pocket [chemical binding]; other site 373994016272 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994016273 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994016274 HEAT repeats; Region: HEAT_2; pfam13646 373994016275 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 373994016276 EamA-like transporter family; Region: EamA; pfam00892 373994016277 EamA-like transporter family; Region: EamA; pfam00892 373994016278 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 373994016279 Uncharacterized conserved protein [Function unknown]; Region: COG3791 373994016280 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 373994016281 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 373994016282 30S subunit binding site; other site 373994016283 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 373994016284 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 373994016285 nucleotide binding site [chemical binding]; other site 373994016286 NEF interaction site [polypeptide binding]; other site 373994016287 SBD interface [polypeptide binding]; other site 373994016288 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 373994016289 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 373994016290 FMN binding site [chemical binding]; other site 373994016291 active site 373994016292 catalytic residues [active] 373994016293 substrate binding site [chemical binding]; other site 373994016294 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 373994016295 HSP70 interaction site [polypeptide binding]; other site 373994016296 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994016297 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994016298 ligand binding site [chemical binding]; other site 373994016299 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 373994016300 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994016301 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994016302 ligand binding site [chemical binding]; other site 373994016303 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 373994016304 putative switch regulator; other site 373994016305 non-specific DNA interactions [nucleotide binding]; other site 373994016306 DNA binding site [nucleotide binding] 373994016307 sequence specific DNA binding site [nucleotide binding]; other site 373994016308 putative cAMP binding site [chemical binding]; other site 373994016309 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 373994016310 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 373994016311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994016312 putative substrate translocation pore; other site 373994016313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994016314 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994016315 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994016316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 373994016317 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 373994016318 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 373994016319 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 373994016320 Protein of unknown function (DUF512); Region: DUF512; pfam04459 373994016321 Bacitracin resistance protein BacA; Region: BacA; pfam02673 373994016322 Bacitracin resistance protein BacA; Region: BacA; pfam02673 373994016323 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 373994016324 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 373994016325 L-aspartate oxidase; Provisional; Region: PRK07395 373994016326 L-aspartate oxidase; Provisional; Region: PRK06175 373994016327 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 373994016328 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994016329 CHASE2 domain; Region: CHASE2; pfam05226 373994016330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994016331 PAS fold; Region: PAS_4; pfam08448 373994016332 putative active site [active] 373994016333 heme pocket [chemical binding]; other site 373994016334 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373994016335 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373994016336 metal binding site [ion binding]; metal-binding site 373994016337 active site 373994016338 I-site; other site 373994016339 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 373994016340 substrate binding site [chemical binding]; other site 373994016341 putative active site [active] 373994016342 redox center [active] 373994016343 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 373994016344 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722 373994016345 phosphate binding site [ion binding]; other site 373994016346 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 373994016347 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 373994016348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994016349 FeS/SAM binding site; other site 373994016350 TRAM domain; Region: TRAM; cl01282 373994016351 helicase 45; Provisional; Region: PTZ00424 373994016352 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 373994016353 ATP binding site [chemical binding]; other site 373994016354 Mg++ binding site [ion binding]; other site 373994016355 motif III; other site 373994016356 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994016357 nucleotide binding region [chemical binding]; other site 373994016358 ATP-binding site [chemical binding]; other site 373994016359 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373994016360 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373994016361 active site 373994016362 catalytic tetrad [active] 373994016363 PUCC protein; Region: PUCC; pfam03209 373994016364 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 373994016365 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 373994016366 active site 373994016367 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 373994016368 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 373994016369 Walker A/P-loop; other site 373994016370 ATP binding site [chemical binding]; other site 373994016371 Q-loop/lid; other site 373994016372 ABC transporter signature motif; other site 373994016373 Walker B; other site 373994016374 D-loop; other site 373994016375 H-loop/switch region; other site 373994016376 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994016377 FtsX-like permease family; Region: FtsX; pfam02687 373994016378 GH3 auxin-responsive promoter; Region: GH3; pfam03321 373994016379 Cupin-like domain; Region: Cupin_8; pfam13621 373994016380 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 373994016381 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 373994016382 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 373994016383 putative active site [active] 373994016384 putative metal binding site [ion binding]; other site 373994016385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994016386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373994016387 putative substrate translocation pore; other site 373994016388 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 373994016389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994016390 S-adenosylmethionine binding site [chemical binding]; other site 373994016391 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 373994016392 Fatty acid desaturase; Region: FA_desaturase; pfam00487 373994016393 Di-iron ligands [ion binding]; other site 373994016394 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 373994016395 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 373994016396 [2Fe-2S] cluster binding site [ion binding]; other site 373994016397 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 373994016398 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 373994016399 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373994016400 catalytic residue [active] 373994016401 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 373994016402 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 373994016403 putative NADP binding site [chemical binding]; other site 373994016404 putative substrate binding site [chemical binding]; other site 373994016405 active site 373994016406 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 373994016407 Protein of unknown function, DUF399; Region: DUF399; pfam04187 373994016408 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 373994016409 UbiA prenyltransferase family; Region: UbiA; pfam01040 373994016410 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 373994016411 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 373994016412 Nucleotide binding site [chemical binding]; other site 373994016413 DTAP/Switch II; other site 373994016414 Switch I; other site 373994016415 UL35; Provisional; Region: PHA03250 373994016416 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 373994016417 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 373994016418 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 373994016419 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 373994016420 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 373994016421 NADP-binding site; other site 373994016422 homotetramer interface [polypeptide binding]; other site 373994016423 substrate binding site [chemical binding]; other site 373994016424 homodimer interface [polypeptide binding]; other site 373994016425 active site 373994016426 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 373994016427 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 373994016428 Walker A/P-loop; other site 373994016429 ATP binding site [chemical binding]; other site 373994016430 Q-loop/lid; other site 373994016431 ABC transporter signature motif; other site 373994016432 Walker B; other site 373994016433 D-loop; other site 373994016434 H-loop/switch region; other site 373994016435 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 373994016436 putative carbohydrate binding site [chemical binding]; other site 373994016437 Methyltransferase domain; Region: Methyltransf_24; pfam13578 373994016438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994016439 S-adenosylmethionine binding site [chemical binding]; other site 373994016440 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 373994016441 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994016442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994016443 S-adenosylmethionine binding site [chemical binding]; other site 373994016444 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994016445 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994016446 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994016447 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373994016448 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 373994016449 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 373994016450 NADP-binding site; other site 373994016451 homotetramer interface [polypeptide binding]; other site 373994016452 substrate binding site [chemical binding]; other site 373994016453 homodimer interface [polypeptide binding]; other site 373994016454 active site 373994016455 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 373994016456 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994016457 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 373994016458 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994016459 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 373994016460 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 373994016461 Walker A/P-loop; other site 373994016462 ATP binding site [chemical binding]; other site 373994016463 Q-loop/lid; other site 373994016464 ABC transporter signature motif; other site 373994016465 Walker B; other site 373994016466 D-loop; other site 373994016467 H-loop/switch region; other site 373994016468 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 373994016469 putative carbohydrate binding site [chemical binding]; other site 373994016470 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994016471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994016472 S-adenosylmethionine binding site [chemical binding]; other site 373994016473 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994016474 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994016475 active site 373994016476 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 373994016477 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 373994016478 Ligand binding site; other site 373994016479 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 373994016480 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 373994016481 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 373994016482 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 373994016483 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 373994016484 NADP binding site [chemical binding]; other site 373994016485 active site 373994016486 putative substrate binding site [chemical binding]; other site 373994016487 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 373994016488 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 373994016489 substrate binding site; other site 373994016490 metal-binding site 373994016491 Oligomer interface; other site 373994016492 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 373994016493 putative trimer interface [polypeptide binding]; other site 373994016494 putative CoA binding site [chemical binding]; other site 373994016495 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 373994016496 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994016497 active site 373994016498 pyruvate kinase; Provisional; Region: PRK06354 373994016499 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 373994016500 domain interfaces; other site 373994016501 active site 373994016502 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 373994016503 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 373994016504 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 373994016505 putative di-iron ligands [ion binding]; other site 373994016506 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 373994016507 homotrimer interaction site [polypeptide binding]; other site 373994016508 active site 373994016509 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 373994016510 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 373994016511 tandem repeat interface [polypeptide binding]; other site 373994016512 oligomer interface [polypeptide binding]; other site 373994016513 active site residues [active] 373994016514 Permease; Region: Permease; cl00510 373994016515 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 373994016516 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 373994016517 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 373994016518 membrane protein; Provisional; Region: PRK14419 373994016519 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 373994016520 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994016521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994016522 S-adenosylmethionine binding site [chemical binding]; other site 373994016523 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373994016524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994016525 NAD(P) binding site [chemical binding]; other site 373994016526 active site 373994016527 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 373994016528 substrate binding site [chemical binding]; other site 373994016529 active site 373994016530 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 373994016531 hypothetical protein; Reviewed; Region: PRK09588 373994016532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994016533 Walker A/P-loop; other site 373994016534 ATP binding site [chemical binding]; other site 373994016535 phosphodiesterase YaeI; Provisional; Region: PRK11340 373994016536 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 373994016537 putative active site [active] 373994016538 putative metal binding site [ion binding]; other site 373994016539 GTP-binding protein Der; Reviewed; Region: PRK00093 373994016540 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 373994016541 G1 box; other site 373994016542 GTP/Mg2+ binding site [chemical binding]; other site 373994016543 Switch I region; other site 373994016544 G2 box; other site 373994016545 Switch II region; other site 373994016546 G3 box; other site 373994016547 G4 box; other site 373994016548 G5 box; other site 373994016549 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 373994016550 G1 box; other site 373994016551 GTP/Mg2+ binding site [chemical binding]; other site 373994016552 Switch I region; other site 373994016553 G2 box; other site 373994016554 G3 box; other site 373994016555 Switch II region; other site 373994016556 G4 box; other site 373994016557 G5 box; other site 373994016558 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 373994016559 anthranilate synthase component I-like protein; Validated; Region: PRK05940 373994016560 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 373994016561 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 373994016562 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 373994016563 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 373994016564 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373994016565 catalytic residue [active] 373994016566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 373994016567 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 373994016568 pyrroline-5-carboxylate reductase; Region: PLN02688 373994016569 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 373994016570 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373994016571 ATP binding site [chemical binding]; other site 373994016572 putative Mg++ binding site [ion binding]; other site 373994016573 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373994016574 nucleotide binding region [chemical binding]; other site 373994016575 ATP-binding site [chemical binding]; other site 373994016576 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 373994016577 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994016578 putative active site [active] 373994016579 GH3 auxin-responsive promoter; Region: GH3; pfam03321 373994016580 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 373994016581 putative trimer interface [polypeptide binding]; other site 373994016582 putative CoA binding site [chemical binding]; other site 373994016583 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 373994016584 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 373994016585 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 373994016586 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 373994016587 [2Fe-2S] cluster binding site [ion binding]; other site 373994016588 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 373994016589 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994016590 catalytic loop [active] 373994016591 iron binding site [ion binding]; other site 373994016592 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 373994016593 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 373994016594 [2Fe-2S] cluster binding site [ion binding]; other site 373994016595 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 373994016596 dinuclear metal binding motif [ion binding]; other site 373994016597 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 373994016598 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 373994016599 [2Fe-2S] cluster binding site [ion binding]; other site 373994016600 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 373994016601 DNA binding residues [nucleotide binding] 373994016602 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 373994016603 dimer interface [polypeptide binding]; other site 373994016604 metal binding site [ion binding]; metal-binding site 373994016605 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994016606 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994016607 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 373994016608 active site 373994016609 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 373994016610 active site 373994016611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 373994016612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994016613 ATP binding site [chemical binding]; other site 373994016614 Mg2+ binding site [ion binding]; other site 373994016615 G-X-G motif; other site 373994016616 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994016617 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994016618 structural tetrad; other site 373994016619 light-harvesting-like protein 3; Provisional; Region: PLN00014 373994016620 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 373994016621 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 373994016622 hexamer interface [polypeptide binding]; other site 373994016623 ligand binding site [chemical binding]; other site 373994016624 putative active site [active] 373994016625 NAD(P) binding site [chemical binding]; other site 373994016626 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994016627 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994016628 active site 373994016629 ATP binding site [chemical binding]; other site 373994016630 substrate binding site [chemical binding]; other site 373994016631 activation loop (A-loop); other site 373994016632 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 373994016633 active site 373994016634 dimer interface [polypeptide binding]; other site 373994016635 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 373994016636 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 373994016637 active site 373994016638 dimer interface [polypeptide binding]; other site 373994016639 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 373994016640 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 373994016641 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 373994016642 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 373994016643 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 373994016644 active site 373994016645 catalytic site [active] 373994016646 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 373994016647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994016648 Walker A/P-loop; other site 373994016649 ATP binding site [chemical binding]; other site 373994016650 Q-loop/lid; other site 373994016651 ABC transporter signature motif; other site 373994016652 Walker B; other site 373994016653 D-loop; other site 373994016654 H-loop/switch region; other site 373994016655 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 373994016656 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 373994016657 hypothetical protein; Provisional; Region: PRK07236 373994016658 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 373994016659 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 373994016660 FMN binding site [chemical binding]; other site 373994016661 active site 373994016662 substrate binding site [chemical binding]; other site 373994016663 catalytic residue [active] 373994016664 Predicted transcriptional regulators [Transcription]; Region: COG1733 373994016665 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 373994016666 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994016667 Phosphotransferase enzyme family; Region: APH; pfam01636 373994016668 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 373994016669 substrate binding site [chemical binding]; other site 373994016670 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 373994016671 Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303 373994016672 inhibitor binding site; inhibition site 373994016673 catalytic motif [active] 373994016674 Catalytic residue [active] 373994016675 Active site flap [active] 373994016676 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373994016677 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373994016678 active site 373994016679 catalytic tetrad [active] 373994016680 KTSC domain; Region: KTSC; pfam13619 373994016681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 373994016682 Tic20-like protein; Region: Tic20; pfam09685 373994016683 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994016684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994016685 motif II; other site 373994016686 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 373994016687 methionine sulfoxide reductase A; Provisional; Region: PRK14054 373994016688 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994016689 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994016690 active site 373994016691 ATP binding site [chemical binding]; other site 373994016692 substrate binding site [chemical binding]; other site 373994016693 activation loop (A-loop); other site 373994016694 Uncharacterized conserved protein [Function unknown]; Region: COG1262 373994016695 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 373994016696 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 373994016697 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 373994016698 active site 373994016699 metal binding site [ion binding]; metal-binding site 373994016700 TPR repeat; Region: TPR_11; pfam13414 373994016701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016702 binding surface 373994016703 TPR motif; other site 373994016704 TPR repeat; Region: TPR_11; pfam13414 373994016705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016706 binding surface 373994016707 TPR motif; other site 373994016708 TPR repeat; Region: TPR_11; pfam13414 373994016709 TPR repeat; Region: TPR_11; pfam13414 373994016710 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016711 binding surface 373994016712 TPR motif; other site 373994016713 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 373994016714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016715 binding surface 373994016716 TPR motif; other site 373994016717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016718 binding surface 373994016719 TPR motif; other site 373994016720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016721 binding surface 373994016722 TPR motif; other site 373994016723 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 373994016724 Uncharacterized conserved protein [Function unknown]; Region: COG4021 373994016725 Thg1 C terminal domain; Region: Thg1C; pfam14413 373994016726 AAA domain; Region: AAA_33; pfam13671 373994016727 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 373994016728 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 373994016729 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 373994016730 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 373994016731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994016732 S-adenosylmethionine binding site [chemical binding]; other site 373994016733 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 373994016734 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 373994016735 homotetramer interface [polypeptide binding]; other site 373994016736 FMN binding site [chemical binding]; other site 373994016737 homodimer contacts [polypeptide binding]; other site 373994016738 putative active site [active] 373994016739 putative substrate binding site [chemical binding]; other site 373994016740 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 373994016741 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 373994016742 tandem repeat interface [polypeptide binding]; other site 373994016743 oligomer interface [polypeptide binding]; other site 373994016744 active site residues [active] 373994016745 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 373994016746 tandem repeat interface [polypeptide binding]; other site 373994016747 oligomer interface [polypeptide binding]; other site 373994016748 active site residues [active] 373994016749 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994016750 Cytochrome P450; Region: p450; pfam00067 373994016751 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 373994016752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994016753 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994016754 WHG domain; Region: WHG; pfam13305 373994016755 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 373994016756 Fatty acid desaturase; Region: FA_desaturase; pfam00487 373994016757 putative di-iron ligands [ion binding]; other site 373994016758 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 373994016759 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 373994016760 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 373994016761 nucleoside/Zn binding site; other site 373994016762 dimer interface [polypeptide binding]; other site 373994016763 catalytic motif [active] 373994016764 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 373994016765 Domain of unknown function (DUF364); Region: DUF364; pfam04016 373994016766 Right handed beta helix region; Region: Beta_helix; pfam13229 373994016767 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 373994016768 putative metal binding site [ion binding]; other site 373994016769 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 373994016770 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 373994016771 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 373994016772 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 373994016773 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 373994016774 Predicted membrane protein [Function unknown]; Region: COG3431 373994016775 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 373994016776 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 373994016777 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 373994016778 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 373994016779 active site 373994016780 ATP binding site [chemical binding]; other site 373994016781 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 373994016782 dimer interface [polypeptide binding]; other site 373994016783 FMN binding site [chemical binding]; other site 373994016784 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994016785 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994016786 ligand binding site [chemical binding]; other site 373994016787 flexible hinge region; other site 373994016788 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 373994016789 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 373994016790 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 373994016791 iron-sulfur cluster [ion binding]; other site 373994016792 [2Fe-2S] cluster binding site [ion binding]; other site 373994016793 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 373994016794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994016795 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 373994016796 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994016797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994016798 dimer interface [polypeptide binding]; other site 373994016799 phosphorylation site [posttranslational modification] 373994016800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994016801 ATP binding site [chemical binding]; other site 373994016802 Mg2+ binding site [ion binding]; other site 373994016803 G-X-G motif; other site 373994016804 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 373994016805 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 373994016806 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373994016807 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373994016808 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 373994016809 PAS fold; Region: PAS_4; pfam08448 373994016810 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994016811 putative active site [active] 373994016812 heme pocket [chemical binding]; other site 373994016813 PAS domain S-box; Region: sensory_box; TIGR00229 373994016814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994016815 putative active site [active] 373994016816 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 373994016817 heme pocket [chemical binding]; other site 373994016818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994016819 putative active site [active] 373994016820 heme pocket [chemical binding]; other site 373994016821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994016822 ATP binding site [chemical binding]; other site 373994016823 Mg2+ binding site [ion binding]; other site 373994016824 G-X-G motif; other site 373994016825 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 373994016826 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 373994016827 Active Sites [active] 373994016828 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 373994016829 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 373994016830 active site 373994016831 metal binding site [ion binding]; metal-binding site 373994016832 DNA binding site [nucleotide binding] 373994016833 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 373994016834 putative metal binding site [ion binding]; other site 373994016835 Right handed beta helix region; Region: Beta_helix; pfam13229 373994016836 Disaggregatase related; Region: Disaggr_assoc; pfam08480 373994016837 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 373994016838 metal binding site [ion binding]; metal-binding site 373994016839 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 373994016840 metal binding site [ion binding]; metal-binding site 373994016841 Right handed beta helix region; Region: Beta_helix; pfam13229 373994016842 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 373994016843 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 373994016844 Surface antigen; Region: Bac_surface_Ag; pfam01103 373994016845 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 373994016846 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 373994016847 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 373994016848 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 373994016849 Probable Catalytic site; other site 373994016850 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 373994016851 active site residue [active] 373994016852 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 373994016853 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 373994016854 methionine sulfoxide reductase A; Provisional; Region: PRK00058 373994016855 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 373994016856 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 373994016857 NAD binding site [chemical binding]; other site 373994016858 substrate binding site [chemical binding]; other site 373994016859 homodimer interface [polypeptide binding]; other site 373994016860 active site 373994016861 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 373994016862 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994016863 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 373994016864 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373994016865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373994016866 DNA binding residues [nucleotide binding] 373994016867 dimerization interface [polypeptide binding]; other site 373994016868 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373994016869 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 373994016870 putative substrate binding site [chemical binding]; other site 373994016871 putative ATP binding site [chemical binding]; other site 373994016872 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 373994016873 ATP-binding site [chemical binding]; other site 373994016874 Gluconate-6-phosphate binding site [chemical binding]; other site 373994016875 Shikimate kinase; Region: SKI; pfam01202 373994016876 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994016877 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994016878 active site 373994016879 ATP binding site [chemical binding]; other site 373994016880 substrate binding site [chemical binding]; other site 373994016881 activation loop (A-loop); other site 373994016882 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 373994016883 active site 373994016884 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 373994016885 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 373994016886 Lipoxygenase; Region: Lipoxygenase; pfam00305 373994016887 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994016888 Cytochrome P450; Region: p450; cl12078 373994016889 Circadian oscillating protein COP23; Region: COP23; pfam14218 373994016890 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 373994016891 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994016892 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 373994016893 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994016894 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 373994016895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016896 binding surface 373994016897 TPR motif; other site 373994016898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016899 TPR motif; other site 373994016900 binding surface 373994016901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016902 binding surface 373994016903 TPR motif; other site 373994016904 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 373994016905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016906 binding surface 373994016907 TPR motif; other site 373994016908 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 373994016909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016910 binding surface 373994016911 TPR motif; other site 373994016912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016913 binding surface 373994016914 TPR motif; other site 373994016915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994016916 TPR motif; other site 373994016917 binding surface 373994016918 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 373994016919 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994016920 active site 373994016921 ATP binding site [chemical binding]; other site 373994016922 substrate binding site [chemical binding]; other site 373994016923 activation loop (A-loop); other site 373994016924 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994016925 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994016926 structural tetrad; other site 373994016927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994016928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994016929 WHG domain; Region: WHG; pfam13305 373994016930 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 373994016931 Amidase; Region: Amidase; pfam01425 373994016932 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 373994016933 Amidase; Region: Amidase; pfam01425 373994016934 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 373994016935 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 373994016936 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 373994016937 beta-phosphoglucomutase; Region: bPGM; TIGR01990 373994016938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994016939 Protein of unknown function DUF45; Region: DUF45; pfam01863 373994016940 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 373994016941 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 373994016942 substrate-cofactor binding pocket; other site 373994016943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994016944 catalytic residue [active] 373994016945 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 373994016946 RuvA N terminal domain; Region: RuvA_N; pfam01330 373994016947 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 373994016948 sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485 373994016949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 373994016950 active site 373994016951 motif I; other site 373994016952 motif II; other site 373994016953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 373994016954 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 373994016955 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 373994016956 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 373994016957 Fasciclin domain; Region: Fasciclin; pfam02469 373994016958 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 373994016959 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; cl07510 373994016960 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994016961 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994016962 structural tetrad; other site 373994016963 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994016964 WD40 repeats; Region: WD40; smart00320 373994016965 WD domain, G-beta repeat; Region: WD40; pfam00400 373994016966 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 373994016967 structural tetrad; other site 373994016968 Tetratricopeptide repeat; Region: TPR_9; pfam13371 373994016969 CHAT domain; Region: CHAT; cl17868 373994016970 TIR domain; Region: TIR_2; pfam13676 373994016971 AAA domain; Region: AAA_14; pfam13173 373994016972 Archaeal ATPase; Region: Arch_ATPase; pfam01637 373994016973 DAK2 domain; Region: Dak2; cl03685 373994016974 Protein kinase domain; Region: Pkinase; pfam00069 373994016975 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994016976 active site 373994016977 ATP binding site [chemical binding]; other site 373994016978 substrate binding site [chemical binding]; other site 373994016979 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994016980 activation loop (A-loop); other site 373994016981 activation loop (A-loop); other site 373994016982 AAA ATPase domain; Region: AAA_16; pfam13191 373994016983 Predicted ATPase [General function prediction only]; Region: COG3899 373994016984 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994016985 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994016986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994016987 ATP binding site [chemical binding]; other site 373994016988 Mg2+ binding site [ion binding]; other site 373994016989 G-X-G motif; other site 373994016990 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 373994016991 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 373994016992 active site 373994016993 active pocket/dimerization site; other site 373994016994 phosphorylation site [posttranslational modification] 373994016995 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 373994016996 regulatory protein interface [polypeptide binding]; other site 373994016997 active site 373994016998 regulatory phosphorylation site [posttranslational modification]; other site 373994016999 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 373994017000 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 373994017001 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 373994017002 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 373994017003 CHAT domain; Region: CHAT; cl17868 373994017004 Exonuclease VII small subunit [DNA replication, recombination, and repair]; Region: XseB; COG1722 373994017005 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 373994017006 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 373994017007 generic binding surface II; other site 373994017008 generic binding surface I; other site 373994017009 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 373994017010 MoxR-like ATPases [General function prediction only]; Region: COG0714 373994017011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994017012 Walker A motif; other site 373994017013 ATP binding site [chemical binding]; other site 373994017014 Walker B motif; other site 373994017015 Uncharacterized conserved protein [Function unknown]; Region: COG1262 373994017016 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 373994017017 Uncharacterized conserved protein [Function unknown]; Region: COG1262 373994017018 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 373994017019 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 373994017020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 373994017021 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 373994017022 ribonuclease PH; Reviewed; Region: rph; PRK00173 373994017023 Ribonuclease PH; Region: RNase_PH_bact; cd11362 373994017024 hexamer interface [polypeptide binding]; other site 373994017025 active site 373994017026 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 373994017027 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 373994017028 putative active site [active] 373994017029 Double zinc ribbon; Region: DZR; pfam12773 373994017030 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 373994017031 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 373994017032 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 373994017033 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994017034 phosphopeptide binding site; other site 373994017035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994017036 S-adenosylmethionine binding site [chemical binding]; other site 373994017037 proton extrusion protein PcxA; Provisional; Region: PRK02507 373994017038 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 373994017039 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 373994017040 Proline dehydrogenase; Region: Pro_dh; cl03282 373994017041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373994017042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994017043 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 373994017044 substrate binding pocket [chemical binding]; other site 373994017045 dimerization interface [polypeptide binding]; other site 373994017046 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 373994017047 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 373994017048 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373994017049 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994017050 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994017051 GUN4-like; Region: GUN4; pfam05419 373994017052 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 373994017053 Predicted permeases [General function prediction only]; Region: COG0795 373994017054 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 373994017055 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 373994017056 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 373994017057 Walker A/P-loop; other site 373994017058 ATP binding site [chemical binding]; other site 373994017059 Q-loop/lid; other site 373994017060 ABC transporter signature motif; other site 373994017061 Walker B; other site 373994017062 D-loop; other site 373994017063 H-loop/switch region; other site 373994017064 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 373994017065 OstA-like protein; Region: OstA; pfam03968 373994017066 Domain of unknown function (DUF309); Region: DUF309; pfam03745 373994017067 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 373994017068 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 373994017069 Protein of unknown function DUF58; Region: DUF58; pfam01882 373994017070 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 373994017071 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994017072 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 373994017073 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 373994017074 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 373994017075 dimerization interface [polypeptide binding]; other site 373994017076 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 373994017077 ATP binding site [chemical binding]; other site 373994017078 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 373994017079 active site 1 [active] 373994017080 dimer interface [polypeptide binding]; other site 373994017081 hexamer interface [polypeptide binding]; other site 373994017082 active site 2 [active] 373994017083 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 373994017084 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 373994017085 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 373994017086 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 373994017087 Acylphosphatase; Region: Acylphosphatase; pfam00708 373994017088 HypF finger; Region: zf-HYPF; pfam07503 373994017089 HypF finger; Region: zf-HYPF; pfam07503 373994017090 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 373994017091 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 373994017092 hypothetical protein; Validated; Region: PRK00068 373994017093 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994017094 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994017095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994017096 binding surface 373994017097 TPR motif; other site 373994017098 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994017099 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994017100 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994017101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 373994017102 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994017103 CHASE2 domain; Region: CHASE2; pfam05226 373994017104 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 373994017105 cyclase homology domain; Region: CHD; cd07302 373994017106 nucleotidyl binding site; other site 373994017107 metal binding site [ion binding]; metal-binding site 373994017108 dimer interface [polypeptide binding]; other site 373994017109 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 373994017110 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 373994017111 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 373994017112 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 373994017113 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 373994017114 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994017115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994017116 AMIN domain; Region: AMIN; pfam11741 373994017117 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 373994017118 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 373994017119 N-terminal plug; other site 373994017120 ligand-binding site [chemical binding]; other site 373994017121 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 373994017122 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 373994017123 siderophore binding site; other site 373994017124 Uncharacterized conserved protein [Function unknown]; Region: COG0398 373994017125 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 373994017126 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 373994017127 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373994017128 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373994017129 active site 373994017130 catalytic tetrad [active] 373994017131 Condensation domain; Region: Condensation; pfam00668 373994017132 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 373994017133 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 373994017134 acyl-activating enzyme (AAE) consensus motif; other site 373994017135 AMP binding site [chemical binding]; other site 373994017136 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 373994017137 Condensation domain; Region: Condensation; pfam00668 373994017138 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 373994017139 thioester reductase domain; Region: Thioester-redct; TIGR01746 373994017140 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 373994017141 putative NAD(P) binding site [chemical binding]; other site 373994017142 active site 373994017143 putative substrate binding site [chemical binding]; other site 373994017144 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 373994017145 active site 373994017146 iron coordination sites [ion binding]; other site 373994017147 substrate binding pocket [chemical binding]; other site 373994017148 Condensation domain; Region: Condensation; pfam00668 373994017149 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 373994017150 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 373994017151 acyl-activating enzyme (AAE) consensus motif; other site 373994017152 AMP binding site [chemical binding]; other site 373994017153 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 373994017154 Condensation domain; Region: Condensation; pfam00668 373994017155 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 373994017156 Condensation domain; Region: Condensation; pfam00668 373994017157 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 373994017158 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 373994017159 acyl-activating enzyme (AAE) consensus motif; other site 373994017160 AMP binding site [chemical binding]; other site 373994017161 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 373994017162 Condensation domain; Region: Condensation; pfam00668 373994017163 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 373994017164 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 373994017165 Condensation domain; Region: Condensation; pfam00668 373994017166 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 373994017167 Nonribosomal peptide synthase; Region: NRPS; pfam08415 373994017168 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 373994017169 acyl-activating enzyme (AAE) consensus motif; other site 373994017170 AMP binding site [chemical binding]; other site 373994017171 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 373994017172 Condensation domain; Region: Condensation; pfam00668 373994017173 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 373994017174 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 373994017175 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 373994017176 acyl-activating enzyme (AAE) consensus motif; other site 373994017177 AMP binding site [chemical binding]; other site 373994017178 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 373994017179 Condensation domain; Region: Condensation; pfam00668 373994017180 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 373994017181 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 373994017182 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 373994017183 acyl-activating enzyme (AAE) consensus motif; other site 373994017184 AMP binding site [chemical binding]; other site 373994017185 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 373994017186 Condensation domain; Region: Condensation; pfam00668 373994017187 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 373994017188 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 373994017189 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 373994017190 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 373994017191 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 373994017192 active site 373994017193 Acyl transferase domain; Region: Acyl_transf_1; cl08282 373994017194 Acyl transferase domain; Region: Acyl_transf_1; cl08282 373994017195 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 373994017196 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 373994017197 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 373994017198 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 373994017199 active site 373994017200 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 373994017201 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 373994017202 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 373994017203 KR domain; Region: KR; pfam08659 373994017204 putative NADP binding site [chemical binding]; other site 373994017205 active site 373994017206 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 373994017207 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 373994017208 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 373994017209 active site 373994017210 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 373994017211 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 373994017212 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 373994017213 acyl-CoA synthetase; Validated; Region: PRK05850 373994017214 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 373994017215 acyl-activating enzyme (AAE) consensus motif; other site 373994017216 active site 373994017217 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 373994017218 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994017219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994017220 AMIN domain; Region: AMIN; pfam11741 373994017221 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 373994017222 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 373994017223 N-terminal plug; other site 373994017224 ligand-binding site [chemical binding]; other site 373994017225 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 373994017226 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 373994017227 siderophore binding site; other site 373994017228 H+ Antiporter protein; Region: 2A0121; TIGR00900 373994017229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994017230 putative substrate translocation pore; other site 373994017231 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 373994017232 putative dimer interface [polypeptide binding]; other site 373994017233 putative [2Fe-2S] cluster binding site [ion binding]; other site 373994017234 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 373994017235 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 373994017236 intersubunit interface [polypeptide binding]; other site 373994017237 H+ Antiporter protein; Region: 2A0121; TIGR00900 373994017238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994017239 putative substrate translocation pore; other site 373994017240 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 373994017241 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 373994017242 siderophore binding site; other site 373994017243 AMIN domain; Region: AMIN; pfam11741 373994017244 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 373994017245 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 373994017246 N-terminal plug; other site 373994017247 ligand-binding site [chemical binding]; other site 373994017248 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 373994017249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373994017250 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 373994017251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 373994017252 Walker A/P-loop; other site 373994017253 ATP binding site [chemical binding]; other site 373994017254 Q-loop/lid; other site 373994017255 ABC transporter signature motif; other site 373994017256 Walker B; other site 373994017257 D-loop; other site 373994017258 H-loop/switch region; other site 373994017259 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 373994017260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994017261 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373994017262 putative substrate translocation pore; other site 373994017263 Predicted membrane protein [Function unknown]; Region: COG1971 373994017264 Domain of unknown function DUF; Region: DUF204; pfam02659 373994017265 Domain of unknown function DUF; Region: DUF204; pfam02659 373994017266 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 373994017267 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373994017268 ABC-ATPase subunit interface; other site 373994017269 dimer interface [polypeptide binding]; other site 373994017270 putative PBP binding regions; other site 373994017271 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 373994017272 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373994017273 ABC-ATPase subunit interface; other site 373994017274 dimer interface [polypeptide binding]; other site 373994017275 putative PBP binding regions; other site 373994017276 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 373994017277 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 373994017278 Walker A/P-loop; other site 373994017279 ATP binding site [chemical binding]; other site 373994017280 Q-loop/lid; other site 373994017281 ABC transporter signature motif; other site 373994017282 Walker B; other site 373994017283 D-loop; other site 373994017284 H-loop/switch region; other site 373994017285 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 373994017286 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 373994017287 catalytic residues [active] 373994017288 catalytic nucleophile [active] 373994017289 Presynaptic Site I dimer interface [polypeptide binding]; other site 373994017290 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 373994017291 Synaptic Flat tetramer interface [polypeptide binding]; other site 373994017292 Synaptic Site I dimer interface [polypeptide binding]; other site 373994017293 DNA binding site [nucleotide binding] 373994017294 Recombinase; Region: Recombinase; pfam07508 373994017295 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 373994017296 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 373994017297 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 373994017298 active site 373994017299 catalytic residues [active] 373994017300 DNA binding site [nucleotide binding] 373994017301 Int/Topo IB signature motif; other site 373994017302 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 373994017303 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 373994017304 sucrose synthase; Region: sucr_synth; TIGR02470 373994017305 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 373994017306 putative ADP-binding pocket [chemical binding]; other site 373994017307 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994017308 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994017309 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017310 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017311 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017312 This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063 373994017313 nickel binding site [ion binding]; other site 373994017314 FOG: CBS domain [General function prediction only]; Region: COG0517 373994017315 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 373994017316 CP12 domain; Region: CP12; cl14670 373994017317 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994017318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994017319 S-adenosylmethionine binding site [chemical binding]; other site 373994017320 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 373994017321 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994017322 catalytic loop [active] 373994017323 iron binding site [ion binding]; other site 373994017324 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 373994017325 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 373994017326 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 373994017327 ATP binding site [chemical binding]; other site 373994017328 substrate interface [chemical binding]; other site 373994017329 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102 373994017330 Rop-like; Region: Rop-like; pfam05082 373994017331 Protein of unknown function, DUF269; Region: DUF269; pfam03270 373994017332 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 373994017333 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 373994017334 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 373994017335 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 373994017336 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 373994017337 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 373994017338 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 373994017339 catalytic residues [active] 373994017340 catalytic nucleophile [active] 373994017341 Presynaptic Site I dimer interface [polypeptide binding]; other site 373994017342 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 373994017343 Synaptic Flat tetramer interface [polypeptide binding]; other site 373994017344 Synaptic Site I dimer interface [polypeptide binding]; other site 373994017345 DNA binding site [nucleotide binding] 373994017346 Recombinase; Region: Recombinase; pfam07508 373994017347 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 373994017348 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994017349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994017350 binding surface 373994017351 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994017352 TPR motif; other site 373994017353 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994017354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 373994017355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994017356 active site 373994017357 phosphorylation site [posttranslational modification] 373994017358 intermolecular recognition site; other site 373994017359 dimerization interface [polypeptide binding]; other site 373994017360 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994017361 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994017362 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994017363 CHAT domain; Region: CHAT; cl17868 373994017364 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994017365 CHASE2 domain; Region: CHASE2; pfam05226 373994017366 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994017367 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 373994017368 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 373994017369 Surface antigen; Region: Bac_surface_Ag; pfam01103 373994017370 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 373994017371 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 373994017372 putative ligand binding site [chemical binding]; other site 373994017373 S-layer homology domain; Region: SLH; pfam00395 373994017374 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 373994017375 Electron transfer DM13; Region: DM13; pfam10517 373994017376 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 373994017377 protein I interface; other site 373994017378 D2 interface; other site 373994017379 protein T interface; other site 373994017380 chlorophyll binding site; other site 373994017381 beta carotene binding site; other site 373994017382 pheophytin binding site; other site 373994017383 manganese-stabilizing polypeptide interface; other site 373994017384 CP43 interface; other site 373994017385 protein L interface; other site 373994017386 oxygen evolving complex binding site; other site 373994017387 bromide binding site; other site 373994017388 quinone binding site; other site 373994017389 Fe binding site [ion binding]; other site 373994017390 core light harvesting interface; other site 373994017391 cytochrome b559 alpha subunit interface; other site 373994017392 cytochrome c-550 interface; other site 373994017393 protein J interface; other site 373994017394 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 373994017395 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 373994017396 Walker A/P-loop; other site 373994017397 ATP binding site [chemical binding]; other site 373994017398 Q-loop/lid; other site 373994017399 ABC transporter signature motif; other site 373994017400 Walker B; other site 373994017401 D-loop; other site 373994017402 H-loop/switch region; other site 373994017403 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 373994017404 Abortive infection C-terminus; Region: Abi_C; pfam14355 373994017405 Putative peptidase family; Region: Metallopep; pfam12044 373994017406 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 373994017407 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 373994017408 TM-ABC transporter signature motif; other site 373994017409 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 373994017410 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 373994017411 TM-ABC transporter signature motif; other site 373994017412 Transposase IS200 like; Region: Y1_Tnp; pfam01797 373994017413 Probable transposase; Region: OrfB_IS605; pfam01385 373994017414 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 373994017415 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994017416 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994017417 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 373994017418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 373994017419 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994017420 CHASE2 domain; Region: CHASE2; pfam05226 373994017421 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 373994017422 cyclase homology domain; Region: CHD; cd07302 373994017423 nucleotidyl binding site; other site 373994017424 metal binding site [ion binding]; metal-binding site 373994017425 dimer interface [polypeptide binding]; other site 373994017426 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 373994017427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994017428 putative substrate translocation pore; other site 373994017429 haemagglutination activity domain; Region: Haemagg_act; pfam05860 373994017430 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994017431 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994017432 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994017433 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994017434 ligand binding site [chemical binding]; other site 373994017435 flexible hinge region; other site 373994017436 tellurium resistance terB-like protein; Region: terB_like; cd07177 373994017437 metal binding site [ion binding]; metal-binding site 373994017438 tellurium resistance terB-like protein; Region: terB_like; cd07177 373994017439 metal binding site [ion binding]; metal-binding site 373994017440 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 373994017441 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994017442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994017443 Walker A/P-loop; other site 373994017444 ATP binding site [chemical binding]; other site 373994017445 Q-loop/lid; other site 373994017446 ABC transporter signature motif; other site 373994017447 Walker B; other site 373994017448 D-loop; other site 373994017449 H-loop/switch region; other site 373994017450 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 373994017451 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 373994017452 active site 373994017453 zinc binding site [ion binding]; other site 373994017454 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 373994017455 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 373994017456 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 373994017457 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 373994017458 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 373994017459 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 373994017460 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 373994017461 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 373994017462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 373994017463 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 373994017464 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373994017465 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 373994017466 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 373994017467 putative active site [active] 373994017468 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373994017469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994017470 Walker A/P-loop; other site 373994017471 ATP binding site [chemical binding]; other site 373994017472 Q-loop/lid; other site 373994017473 ABC transporter signature motif; other site 373994017474 Walker B; other site 373994017475 D-loop; other site 373994017476 H-loop/switch region; other site 373994017477 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373994017478 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 373994017479 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994017480 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994017481 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 373994017482 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994017483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994017484 TPR motif; other site 373994017485 binding surface 373994017486 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994017487 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994017488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 373994017489 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 373994017490 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 373994017491 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 373994017492 active site 373994017493 catalytic residues [active] 373994017494 DNA binding site [nucleotide binding] 373994017495 Int/Topo IB signature motif; other site 373994017496 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 373994017497 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 373994017498 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 373994017499 Predicted membrane protein [Function unknown]; Region: COG3431 373994017500 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 373994017501 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 373994017502 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 373994017503 RibD C-terminal domain; Region: RibD_C; cl17279 373994017504 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 373994017505 2-phosphoglycerate kinase [Carbohydrate transport and metabolism]; Region: COG2074 373994017506 AAA domain; Region: AAA_17; pfam13207 373994017507 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 373994017508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 373994017509 non-specific DNA binding site [nucleotide binding]; other site 373994017510 salt bridge; other site 373994017511 sequence-specific DNA binding site [nucleotide binding]; other site 373994017512 elongation factor G; Reviewed; Region: PRK00007 373994017513 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 373994017514 G1 box; other site 373994017515 putative GEF interaction site [polypeptide binding]; other site 373994017516 GTP/Mg2+ binding site [chemical binding]; other site 373994017517 Switch I region; other site 373994017518 G2 box; other site 373994017519 G3 box; other site 373994017520 Switch II region; other site 373994017521 G4 box; other site 373994017522 G5 box; other site 373994017523 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 373994017524 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 373994017525 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 373994017526 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 373994017527 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373994017528 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 373994017529 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 373994017530 acyl-activating enzyme (AAE) consensus motif; other site 373994017531 AMP binding site [chemical binding]; other site 373994017532 active site 373994017533 CoA binding site [chemical binding]; other site 373994017534 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 373994017535 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 373994017536 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 373994017537 FAD binding domain; Region: FAD_binding_4; pfam01565 373994017538 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 373994017539 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 373994017540 active site 373994017541 catalytic residues [active] 373994017542 DNA binding site [nucleotide binding] 373994017543 Int/Topo IB signature motif; other site 373994017544 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 373994017545 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994017546 active site 373994017547 multiple promoter invertase; Provisional; Region: mpi; PRK13413 373994017548 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 373994017549 catalytic residues [active] 373994017550 catalytic nucleophile [active] 373994017551 Presynaptic Site I dimer interface [polypeptide binding]; other site 373994017552 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 373994017553 Synaptic Flat tetramer interface [polypeptide binding]; other site 373994017554 Synaptic Site I dimer interface [polypeptide binding]; other site 373994017555 DNA binding site [nucleotide binding] 373994017556 Recombinase; Region: Recombinase; pfam07508 373994017557 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 373994017558 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 373994017559 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 373994017560 metal ion-dependent adhesion site (MIDAS); other site 373994017561 Calx-beta domain; Region: Calx-beta; cl02522 373994017562 Calx-beta domain; Region: Calx-beta; cl02522 373994017563 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 373994017564 Ca2+ binding site [ion binding]; other site 373994017565 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 373994017566 Ca2+ binding site [ion binding]; other site 373994017567 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 373994017568 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 373994017569 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 373994017570 active site 373994017571 catalytic residues [active] 373994017572 DNA binding site [nucleotide binding] 373994017573 Int/Topo IB signature motif; other site 373994017574 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 373994017575 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 373994017576 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 373994017577 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994017578 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994017579 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 373994017580 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 373994017581 Electron transfer DM13; Region: DM13; pfam10517 373994017582 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 373994017583 CHASE2 domain; Region: CHASE2; pfam05226 373994017584 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 373994017585 cyclase homology domain; Region: CHD; cd07302 373994017586 nucleotidyl binding site; other site 373994017587 metal binding site [ion binding]; metal-binding site 373994017588 dimer interface [polypeptide binding]; other site 373994017589 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 373994017590 Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476 373994017591 putative active site [active] 373994017592 putative catalytic triad [active] 373994017593 cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895 373994017594 cyanobactin biosynthesis protein, PatB/AcyB/McaB family; Region: patB_acyB_mcaB; TIGR04220 373994017595 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 373994017596 YcaO-like family; Region: YcaO; pfam02624 373994017597 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 373994017598 bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678 373994017599 bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678 373994017600 bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678 373994017601 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 373994017602 putative FMN binding site [chemical binding]; other site 373994017603 NADPH bind site [chemical binding]; other site 373994017604 Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476 373994017605 putative active site [active] 373994017606 putative catalytic triad [active] 373994017607 cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895 373994017608 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 373994017609 putative active site [active] 373994017610 putative metal binding site [ion binding]; other site 373994017611 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994017612 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994017613 von Willebrand factor type A domain; Region: VWA_2; pfam13519 373994017614 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 373994017615 active site flap/lid [active] 373994017616 nucleophilic elbow; other site 373994017617 catalytic triad [active] 373994017618 Lamin Tail Domain; Region: LTD; pfam00932 373994017619 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 373994017620 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994017621 FeS/SAM binding site; other site 373994017622 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 373994017623 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 373994017624 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 373994017625 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 373994017626 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 373994017627 PqqA family; Region: PqqA; cl15372 373994017628 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 373994017629 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 373994017630 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994017631 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 373994017632 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994017633 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 373994017634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994017635 binding surface 373994017636 TPR motif; other site 373994017637 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994017638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 373994017639 binding surface 373994017640 TPR motif; other site 373994017641 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994017642 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994017643 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994017644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 373994017645 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 373994017646 active site 373994017647 catalytic triad [active] 373994017648 oxyanion hole [active] 373994017649 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 373994017650 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 373994017651 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 373994017652 catalytic residues [active] 373994017653 catalytic nucleophile [active] 373994017654 Presynaptic Site I dimer interface [polypeptide binding]; other site 373994017655 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 373994017656 Synaptic Flat tetramer interface [polypeptide binding]; other site 373994017657 Synaptic Site I dimer interface [polypeptide binding]; other site 373994017658 DNA binding site [nucleotide binding] 373994017659 Recombinase; Region: Recombinase; pfam07508 373994017660 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 373994017661 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 373994017662 nitrogenase iron protein; Region: nifH; TIGR01287 373994017663 Nucleotide-binding sites [chemical binding]; other site 373994017664 Walker A motif; other site 373994017665 Switch I region of nucleotide binding site; other site 373994017666 Fe4S4 binding sites [ion binding]; other site 373994017667 Switch II region of nucleotide binding site; other site 373994017668 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 373994017669 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 373994017670 trimerization site [polypeptide binding]; other site 373994017671 active site 373994017672 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 373994017673 NifU-like domain; Region: NifU; pfam01106 373994017674 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 373994017675 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 373994017676 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373994017677 catalytic residue [active] 373994017678 4Fe-4S binding domain; Region: Fer4; cl02805 373994017679 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 373994017680 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 373994017681 active site 373994017682 catalytic residues [active] 373994017683 DNA binding site [nucleotide binding] 373994017684 Int/Topo IB signature motif; other site 373994017685 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 373994017686 active site 373994017687 catalytic residues [active] 373994017688 DNA binding site [nucleotide binding] 373994017689 Int/Topo IB signature motif; other site 373994017690 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 373994017691 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 373994017692 putative NAD(P) binding site [chemical binding]; other site 373994017693 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 373994017694 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 373994017695 inhibitor-cofactor binding pocket; inhibition site 373994017696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994017697 catalytic residue [active] 373994017698 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 373994017699 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 373994017700 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 373994017701 trimer interface [polypeptide binding]; other site 373994017702 active site 373994017703 substrate binding site [chemical binding]; other site 373994017704 CoA binding site [chemical binding]; other site 373994017705 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 373994017706 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 373994017707 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 373994017708 active site 373994017709 catalytic residues [active] 373994017710 metal binding site [ion binding]; metal-binding site 373994017711 NifZ domain; Region: NifZ; pfam04319 373994017712 NifT/FixU protein; Region: NifT; pfam06988 373994017713 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 373994017714 dimer interface [polypeptide binding]; other site 373994017715 [2Fe-2S] cluster binding site [ion binding]; other site 373994017716 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 373994017717 N-terminal plug; other site 373994017718 ligand-binding site [chemical binding]; other site 373994017719 AMIN domain; Region: AMIN; pfam11741 373994017720 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 373994017721 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 373994017722 N-terminal plug; other site 373994017723 ligand-binding site [chemical binding]; other site 373994017724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373994017725 muropeptide transporter; Reviewed; Region: ampG; PRK11902 373994017726 putative substrate translocation pore; other site 373994017727 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994017728 putative active site [active] 373994017729 MoxR-like ATPases [General function prediction only]; Region: COG0714 373994017730 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 373994017731 Walker A motif; other site 373994017732 ATP binding site [chemical binding]; other site 373994017733 Walker B motif; other site 373994017734 arginine finger; other site 373994017735 SWIM zinc finger; Region: SWIM; pfam04434 373994017736 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 373994017737 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 373994017738 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 373994017739 generic binding surface I; other site 373994017740 generic binding surface II; other site 373994017741 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 373994017742 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 373994017743 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 373994017744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994017745 non-specific DNA binding site [nucleotide binding]; other site 373994017746 salt bridge; other site 373994017747 sequence-specific DNA binding site [nucleotide binding]; other site 373994017748 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 373994017749 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 373994017750 Helix-turn-helix domain; Region: HTH_25; pfam13413 373994017751 gamma-glutamyl kinase; Provisional; Region: PRK05429 373994017752 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 373994017753 nucleotide binding site [chemical binding]; other site 373994017754 homotetrameric interface [polypeptide binding]; other site 373994017755 putative phosphate binding site [ion binding]; other site 373994017756 putative allosteric binding site; other site 373994017757 PUA domain; Region: PUA; pfam01472 373994017758 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994017759 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017760 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994017761 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017762 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017763 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017764 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 373994017765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994017766 active site 373994017767 motif I; other site 373994017768 motif II; other site 373994017769 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994017770 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017771 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017772 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017773 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017774 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017775 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017776 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994017777 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017778 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 373994017779 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 373994017780 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 373994017781 putative dimer interface [polypeptide binding]; other site 373994017782 N-terminal domain interface [polypeptide binding]; other site 373994017783 putative substrate binding pocket (H-site) [chemical binding]; other site 373994017784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994017785 dimer interface [polypeptide binding]; other site 373994017786 conserved gate region; other site 373994017787 putative PBP binding loops; other site 373994017788 ABC-ATPase subunit interface; other site 373994017789 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373994017790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994017791 dimer interface [polypeptide binding]; other site 373994017792 conserved gate region; other site 373994017793 putative PBP binding loops; other site 373994017794 ABC-ATPase subunit interface; other site 373994017795 cytochrome c-550; Provisional; Region: psbV; PRK13618 373994017796 cytochrome c-550; Provisional; Region: psbV; PRK13621 373994017797 cytochrome c-550; Provisional; Region: psbV; cl17239 373994017798 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 373994017799 plastocyanin; Provisional; Region: PRK02710 373994017800 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 373994017801 PGAP1-like protein; Region: PGAP1; pfam07819 373994017802 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 373994017803 intrachain domain interface; other site 373994017804 heme bH binding site [chemical binding]; other site 373994017805 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 373994017806 heme bL binding site [chemical binding]; other site 373994017807 interchain domain interface [polypeptide binding]; other site 373994017808 Qo binding site; other site 373994017809 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 373994017810 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 373994017811 TrkA-N domain; Region: TrkA_N; pfam02254 373994017812 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 373994017813 putative hydrophobic ligand binding site [chemical binding]; other site 373994017814 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994017815 GAF domain; Region: GAF; pfam01590 373994017816 GAF domain; Region: GAF; pfam01590 373994017817 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994017818 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994017819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994017820 dimer interface [polypeptide binding]; other site 373994017821 phosphorylation site [posttranslational modification] 373994017822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994017823 ATP binding site [chemical binding]; other site 373994017824 Mg2+ binding site [ion binding]; other site 373994017825 G-X-G motif; other site 373994017826 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 373994017827 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 373994017828 active site 373994017829 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 373994017830 peripheral dimer interface [polypeptide binding]; other site 373994017831 core dimer interface [polypeptide binding]; other site 373994017832 L10 interface [polypeptide binding]; other site 373994017833 L11 interface [polypeptide binding]; other site 373994017834 putative EF-Tu interaction site [polypeptide binding]; other site 373994017835 putative EF-G interaction site [polypeptide binding]; other site 373994017836 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 373994017837 metal ion-dependent adhesion site (MIDAS); other site 373994017838 Elongation factor TS; Region: EF_TS; pfam00889 373994017839 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373994017840 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 373994017841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994017842 Walker A motif; other site 373994017843 ATP binding site [chemical binding]; other site 373994017844 Walker B motif; other site 373994017845 arginine finger; other site 373994017846 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 373994017847 nudix motif; other site 373994017848 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994017849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994017850 S-adenosylmethionine binding site [chemical binding]; other site 373994017851 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 373994017852 dimer interface [polypeptide binding]; other site 373994017853 motif 1; other site 373994017854 active site 373994017855 motif 2; other site 373994017856 motif 3; other site 373994017857 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 373994017858 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 373994017859 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 373994017860 Competence protein; Region: Competence; pfam03772 373994017861 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 373994017862 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 373994017863 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 373994017864 putative active site [active] 373994017865 putative metal binding site [ion binding]; other site 373994017866 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 373994017867 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 373994017868 Ligand Binding Site [chemical binding]; other site 373994017869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994017870 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994017871 dimer interface [polypeptide binding]; other site 373994017872 phosphorylation site [posttranslational modification] 373994017873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994017874 ATP binding site [chemical binding]; other site 373994017875 Mg2+ binding site [ion binding]; other site 373994017876 G-X-G motif; other site 373994017877 Response regulator receiver domain; Region: Response_reg; pfam00072 373994017878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994017879 active site 373994017880 phosphorylation site [posttranslational modification] 373994017881 intermolecular recognition site; other site 373994017882 dimerization interface [polypeptide binding]; other site 373994017883 PsaX family; Region: PsaX; pfam08078 373994017884 lipoyl synthase; Provisional; Region: PRK12928 373994017885 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994017886 FeS/SAM binding site; other site 373994017887 Response regulator receiver domain; Region: Response_reg; pfam00072 373994017888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994017889 active site 373994017890 phosphorylation site [posttranslational modification] 373994017891 intermolecular recognition site; other site 373994017892 dimerization interface [polypeptide binding]; other site 373994017893 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994017894 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994017895 active site 373994017896 ATP binding site [chemical binding]; other site 373994017897 substrate binding site [chemical binding]; other site 373994017898 activation loop (A-loop); other site 373994017899 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373994017900 AAA ATPase domain; Region: AAA_16; pfam13191 373994017901 Predicted ATPase [General function prediction only]; Region: COG3899 373994017902 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994017903 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994017904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994017905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994017906 dimer interface [polypeptide binding]; other site 373994017907 phosphorylation site [posttranslational modification] 373994017908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994017909 ATP binding site [chemical binding]; other site 373994017910 Mg2+ binding site [ion binding]; other site 373994017911 G-X-G motif; other site 373994017912 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 373994017913 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 373994017914 substrate binding pocket [chemical binding]; other site 373994017915 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 373994017916 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 373994017917 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 373994017918 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 373994017919 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 373994017920 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373994017921 Uncharacterized conserved protein [Function unknown]; Region: COG0393 373994017922 TPR repeat; Region: TPR_11; pfam13414 373994017923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994017924 binding surface 373994017925 TPR motif; other site 373994017926 TPR repeat; Region: TPR_11; pfam13414 373994017927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994017928 binding surface 373994017929 TPR motif; other site 373994017930 NAD synthetase; Provisional; Region: PRK13981 373994017931 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 373994017932 multimer interface [polypeptide binding]; other site 373994017933 active site 373994017934 catalytic triad [active] 373994017935 protein interface 1 [polypeptide binding]; other site 373994017936 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 373994017937 homodimer interface [polypeptide binding]; other site 373994017938 NAD binding pocket [chemical binding]; other site 373994017939 ATP binding pocket [chemical binding]; other site 373994017940 Mg binding site [ion binding]; other site 373994017941 active-site loop [active] 373994017942 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 373994017943 nudix motif; other site 373994017944 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 373994017945 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 373994017946 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 373994017947 active site 373994017948 (T/H)XGH motif; other site 373994017949 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 373994017950 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 373994017951 active site 373994017952 Homeodomain-like domain; Region: HTH_23; pfam13384 373994017953 Winged helix-turn helix; Region: HTH_29; pfam13551 373994017954 Homeodomain-like domain; Region: HTH_32; pfam13565 373994017955 DDE superfamily endonuclease; Region: DDE_3; pfam13358 373994017956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 373994017957 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 373994017958 Haemolytic domain; Region: Haemolytic; pfam01809 373994017959 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 373994017960 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 373994017961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373994017962 active site 373994017963 catalytic tetrad [active] 373994017964 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994017965 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017966 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994017967 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017968 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017969 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994017970 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 373994017971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994017972 dimer interface [polypeptide binding]; other site 373994017973 conserved gate region; other site 373994017974 putative PBP binding loops; other site 373994017975 ABC-ATPase subunit interface; other site 373994017976 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 373994017977 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 373994017978 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 373994017979 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 373994017980 active site 373994017981 substrate binding site [chemical binding]; other site 373994017982 cosubstrate binding site; other site 373994017983 catalytic site [active] 373994017984 elongation factor P; Validated; Region: PRK00529 373994017985 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 373994017986 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 373994017987 RNA binding site [nucleotide binding]; other site 373994017988 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 373994017989 RNA binding site [nucleotide binding]; other site 373994017990 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 373994017991 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 373994017992 carboxyltransferase (CT) interaction site; other site 373994017993 biotinylation site [posttranslational modification]; other site 373994017994 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373994017995 putative DNA binding site [nucleotide binding]; other site 373994017996 putative Zn2+ binding site [ion binding]; other site 373994017997 Sporulation and spore germination; Region: Germane; pfam10646 373994017998 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 373994017999 prolyl-tRNA synthetase; Provisional; Region: PRK09194 373994018000 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 373994018001 dimer interface [polypeptide binding]; other site 373994018002 motif 1; other site 373994018003 active site 373994018004 motif 2; other site 373994018005 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 373994018006 putative deacylase active site [active] 373994018007 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 373994018008 active site 373994018009 motif 3; other site 373994018010 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 373994018011 anticodon binding site; other site 373994018012 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 373994018013 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 373994018014 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994018015 putative active site [active] 373994018016 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 373994018017 GSH binding site [chemical binding]; other site 373994018018 catalytic residues [active] 373994018019 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 373994018020 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 373994018021 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 373994018022 hypothetical protein; Provisional; Region: PRK08244 373994018023 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 373994018024 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 373994018025 Walker A/P-loop; other site 373994018026 ATP binding site [chemical binding]; other site 373994018027 Q-loop/lid; other site 373994018028 ABC transporter signature motif; other site 373994018029 Walker B; other site 373994018030 D-loop; other site 373994018031 H-loop/switch region; other site 373994018032 DevC protein; Region: devC; TIGR01185 373994018033 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373994018034 FtsX-like permease family; Region: FtsX; pfam02687 373994018035 Peptidase family M23; Region: Peptidase_M23; pfam01551 373994018036 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 373994018037 HlyD family secretion protein; Region: HlyD_3; pfam13437 373994018038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994018039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994018040 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 373994018041 Methyltransferase domain; Region: Methyltransf_23; pfam13489 373994018042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994018043 S-adenosylmethionine binding site [chemical binding]; other site 373994018044 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 373994018045 Electron transfer DM13; Region: DM13; pfam10517 373994018046 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 373994018047 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 373994018048 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 373994018049 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 373994018050 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994018051 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994018052 ligand binding site [chemical binding]; other site 373994018053 flexible hinge region; other site 373994018054 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994018055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994018056 ATP binding site [chemical binding]; other site 373994018057 Mg2+ binding site [ion binding]; other site 373994018058 G-X-G motif; other site 373994018059 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994018060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994018061 active site 373994018062 phosphorylation site [posttranslational modification] 373994018063 intermolecular recognition site; other site 373994018064 dimerization interface [polypeptide binding]; other site 373994018065 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 373994018066 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 373994018067 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373994018068 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994018069 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 373994018070 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373994018071 active site 373994018072 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 373994018073 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 373994018074 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 373994018075 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 373994018076 Src Homology 3 domain superfamily; Region: SH3; cl17036 373994018077 peptide ligand binding site [polypeptide binding]; other site 373994018078 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 373994018079 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 373994018080 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994018081 catalytic loop [active] 373994018082 iron binding site [ion binding]; other site 373994018083 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 373994018084 multidrug efflux protein; Reviewed; Region: PRK01766 373994018085 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 373994018086 cation binding site [ion binding]; other site 373994018087 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 373994018088 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 373994018089 metal ion-dependent adhesion site (MIDAS); other site 373994018090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 373994018091 BON domain; Region: BON; pfam04972 373994018092 Predicted membrane protein [Function unknown]; Region: COG2323 373994018093 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 373994018094 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 373994018095 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 373994018096 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 373994018097 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 373994018098 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373994018099 Zn binding site [ion binding]; other site 373994018100 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994018101 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373994018102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373994018103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373994018104 LysR substrate binding domain; Region: LysR_substrate; pfam03466 373994018105 dimerization interface [polypeptide binding]; other site 373994018106 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 373994018107 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 373994018108 oligomeric interface; other site 373994018109 putative active site [active] 373994018110 homodimer interface [polypeptide binding]; other site 373994018111 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 373994018112 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373994018113 G1 box; other site 373994018114 GTP/Mg2+ binding site [chemical binding]; other site 373994018115 G2 box; other site 373994018116 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 373994018117 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 373994018118 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 373994018119 putative catalytic residues [active] 373994018120 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 373994018121 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 373994018122 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 373994018123 Subunit I/III interface [polypeptide binding]; other site 373994018124 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 373994018125 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 373994018126 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 373994018127 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 373994018128 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 373994018129 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 373994018130 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 373994018131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994018132 non-specific DNA binding site [nucleotide binding]; other site 373994018133 salt bridge; other site 373994018134 sequence-specific DNA binding site [nucleotide binding]; other site 373994018135 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 373994018136 putative catalytic site [active] 373994018137 putative metal binding site [ion binding]; other site 373994018138 putative phosphate binding site [ion binding]; other site 373994018139 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 373994018140 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 373994018141 dimer interface [polypeptide binding]; other site 373994018142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994018143 catalytic residue [active] 373994018144 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 373994018145 putative active site [active] 373994018146 putative metal binding site [ion binding]; other site 373994018147 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 373994018148 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 373994018149 Walker A/P-loop; other site 373994018150 ATP binding site [chemical binding]; other site 373994018151 Q-loop/lid; other site 373994018152 ABC transporter signature motif; other site 373994018153 Walker B; other site 373994018154 D-loop; other site 373994018155 H-loop/switch region; other site 373994018156 TOBE domain; Region: TOBE_2; pfam08402 373994018157 GUN4-like; Region: GUN4; pfam05419 373994018158 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 373994018159 isocitrate dehydrogenase; Validated; Region: PRK07362 373994018160 HEAT repeats; Region: HEAT_2; pfam13646 373994018161 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 373994018162 HEAT repeats; Region: HEAT_2; pfam13646 373994018163 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 373994018164 MarR family; Region: MarR; pfam01047 373994018165 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 373994018166 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 373994018167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373994018168 active site 373994018169 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994018170 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994018171 active site 373994018172 ATP binding site [chemical binding]; other site 373994018173 substrate binding site [chemical binding]; other site 373994018174 activation loop (A-loop); other site 373994018175 AAA domain; Region: AAA_26; pfam13500 373994018176 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 373994018177 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 373994018178 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 373994018179 metal binding site [ion binding]; metal-binding site 373994018180 dimer interface [polypeptide binding]; other site 373994018181 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 373994018182 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 373994018183 C-terminal domain interface [polypeptide binding]; other site 373994018184 GSH binding site (G-site) [chemical binding]; other site 373994018185 dimer interface [polypeptide binding]; other site 373994018186 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 373994018187 N-terminal domain interface [polypeptide binding]; other site 373994018188 putative dimer interface [polypeptide binding]; other site 373994018189 active site 373994018190 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994018191 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994018192 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994018193 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994018194 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994018195 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994018196 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 373994018197 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994018198 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994018199 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 373994018200 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 373994018201 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 373994018202 dimerization interface [polypeptide binding]; other site 373994018203 putative ATP binding site [chemical binding]; other site 373994018204 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373994018205 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373994018206 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373994018207 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373994018208 Domain of unknown function (DUF4419); Region: DUF4419; pfam14388 373994018209 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373994018210 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 373994018211 active site 373994018212 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 373994018213 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 373994018214 DctM-like transporters; Region: DctM; pfam06808 373994018215 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 373994018216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994018217 binding surface 373994018218 TPR motif; other site 373994018219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994018220 binding surface 373994018221 TPR motif; other site 373994018222 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 373994018223 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994018224 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 373994018225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994018226 non-specific DNA binding site [nucleotide binding]; other site 373994018227 salt bridge; other site 373994018228 sequence-specific DNA binding site [nucleotide binding]; other site 373994018229 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 373994018230 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 373994018231 hypothetical protein; Provisional; Region: PRK09256 373994018232 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 373994018233 putative active site [active] 373994018234 Pirin-related protein [General function prediction only]; Region: COG1741 373994018235 Pirin; Region: Pirin; pfam02678 373994018236 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 373994018237 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 373994018238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 373994018239 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 373994018240 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994018241 catalytic loop [active] 373994018242 iron binding site [ion binding]; other site 373994018243 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 373994018244 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994018245 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373994018246 active site 373994018247 metal binding site [ion binding]; metal-binding site 373994018248 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 373994018249 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 373994018250 EF-hand domain pair; Region: EF_hand_5; pfam13499 373994018251 Ca2+ binding site [ion binding]; other site 373994018252 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 373994018253 putative catalytic site [active] 373994018254 putative metal binding site [ion binding]; other site 373994018255 putative phosphate binding site [ion binding]; other site 373994018256 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 373994018257 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 373994018258 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 373994018259 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 373994018260 active site 373994018261 oxyanion hole [active] 373994018262 catalytic triad [active] 373994018263 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 373994018264 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 373994018265 Uncharacterized conserved protein [Function unknown]; Region: COG5361 373994018266 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 373994018267 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 373994018268 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373994018269 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373994018270 ligand binding site [chemical binding]; other site 373994018271 flexible hinge region; other site 373994018272 MarR family; Region: MarR; pfam01047 373994018273 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 373994018274 Thioredoxin; Region: Thioredoxin_4; cl17273 373994018275 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 373994018276 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 373994018277 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 373994018278 endonuclease III; Region: ENDO3c; smart00478 373994018279 minor groove reading motif; other site 373994018280 helix-hairpin-helix signature motif; other site 373994018281 substrate binding pocket [chemical binding]; other site 373994018282 active site 373994018283 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 373994018284 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 373994018285 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 373994018286 Phospholipid methyltransferase; Region: PEMT; cl17370 373994018287 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 373994018288 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 373994018289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 373994018290 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 373994018291 RNA ligase; Region: RNA_lig_T4_1; pfam09511 373994018292 GAF domain; Region: GAF_2; pfam13185 373994018293 GAF domain; Region: GAF_3; pfam13492 373994018294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994018295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994018296 dimer interface [polypeptide binding]; other site 373994018297 phosphorylation site [posttranslational modification] 373994018298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994018299 ATP binding site [chemical binding]; other site 373994018300 Mg2+ binding site [ion binding]; other site 373994018301 G-X-G motif; other site 373994018302 CHASE3 domain; Region: CHASE3; cl05000 373994018303 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 373994018304 HAMP domain; Region: HAMP; pfam00672 373994018305 dimerization interface [polypeptide binding]; other site 373994018306 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 373994018307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994018308 putative active site [active] 373994018309 heme pocket [chemical binding]; other site 373994018310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994018311 dimer interface [polypeptide binding]; other site 373994018312 phosphorylation site [posttranslational modification] 373994018313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994018314 ATP binding site [chemical binding]; other site 373994018315 Mg2+ binding site [ion binding]; other site 373994018316 G-X-G motif; other site 373994018317 Response regulator receiver domain; Region: Response_reg; pfam00072 373994018318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994018319 active site 373994018320 phosphorylation site [posttranslational modification] 373994018321 intermolecular recognition site; other site 373994018322 dimerization interface [polypeptide binding]; other site 373994018323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994018324 phosphorylation site [posttranslational modification] 373994018325 Response regulator receiver domain; Region: Response_reg; pfam00072 373994018326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994018327 active site 373994018328 phosphorylation site [posttranslational modification] 373994018329 intermolecular recognition site; other site 373994018330 dimerization interface [polypeptide binding]; other site 373994018331 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 373994018332 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 373994018333 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 373994018334 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 373994018335 GTP-binding protein YchF; Reviewed; Region: PRK09601 373994018336 YchF GTPase; Region: YchF; cd01900 373994018337 G1 box; other site 373994018338 GTP/Mg2+ binding site [chemical binding]; other site 373994018339 Switch I region; other site 373994018340 G2 box; other site 373994018341 Switch II region; other site 373994018342 G3 box; other site 373994018343 G4 box; other site 373994018344 G5 box; other site 373994018345 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 373994018346 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 373994018347 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 373994018348 homodimer interface [polypeptide binding]; other site 373994018349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994018350 catalytic residue [active] 373994018351 glucokinase; Provisional; Region: glk; PRK00292 373994018352 glucokinase, proteobacterial type; Region: glk; TIGR00749 373994018353 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 373994018354 catalytic core [active] 373994018355 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 373994018356 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 373994018357 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 373994018358 active site 373994018359 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 373994018360 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373994018361 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994018362 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373994018363 active site 373994018364 metal binding site [ion binding]; metal-binding site 373994018365 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 373994018366 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 373994018367 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 373994018368 ADP-ribose binding site [chemical binding]; other site 373994018369 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 373994018370 Response regulator receiver domain; Region: Response_reg; pfam00072 373994018371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994018372 active site 373994018373 phosphorylation site [posttranslational modification] 373994018374 intermolecular recognition site; other site 373994018375 dimerization interface [polypeptide binding]; other site 373994018376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994018377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994018378 Cytochrome P450; Region: p450; pfam00067 373994018379 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 373994018380 S-layer homology domain; Region: SLH; pfam00395 373994018381 S-layer homology domain; Region: SLH; pfam00395 373994018382 Cache domain; Region: Cache_1; pfam02743 373994018383 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994018384 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994018385 dimerization interface [polypeptide binding]; other site 373994018386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994018387 ATP binding site [chemical binding]; other site 373994018388 Mg2+ binding site [ion binding]; other site 373994018389 G-X-G motif; other site 373994018390 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 373994018391 DNA-binding interface [nucleotide binding]; DNA binding site 373994018392 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 373994018393 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 373994018394 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 373994018395 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 373994018396 active site 373994018397 TDP-binding site; other site 373994018398 acceptor substrate-binding pocket; other site 373994018399 homodimer interface [polypeptide binding]; other site 373994018400 Protein of function (DUF2518); Region: DUF2518; pfam10726 373994018401 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994018402 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 373994018403 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 373994018404 putative active site [active] 373994018405 metal binding site [ion binding]; metal-binding site 373994018406 aspartate aminotransferase; Provisional; Region: PRK05942 373994018407 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373994018408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994018409 homodimer interface [polypeptide binding]; other site 373994018410 catalytic residue [active] 373994018411 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373994018412 dimerization interface [polypeptide binding]; other site 373994018413 putative DNA binding site [nucleotide binding]; other site 373994018414 putative Zn2+ binding site [ion binding]; other site 373994018415 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 373994018416 amphipathic channel; other site 373994018417 Asn-Pro-Ala signature motifs; other site 373994018418 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 373994018419 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 373994018420 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 373994018421 Low molecular weight phosphatase family; Region: LMWPc; cd00115 373994018422 active site 373994018423 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 373994018424 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373994018425 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373994018426 DNA photolyase; Region: DNA_photolyase; pfam00875 373994018427 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994018428 putative active site [active] 373994018429 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 373994018430 ArsC family; Region: ArsC; pfam03960 373994018431 catalytic residue [active] 373994018432 Protein of unknown function (DUF433); Region: DUF433; cl01030 373994018433 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 373994018434 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 373994018435 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994018436 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994018437 active site 373994018438 ATP binding site [chemical binding]; other site 373994018439 substrate binding site [chemical binding]; other site 373994018440 activation loop (A-loop); other site 373994018441 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 373994018442 VanW like protein; Region: VanW; pfam04294 373994018443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373994018444 Radical SAM superfamily; Region: Radical_SAM; pfam04055 373994018445 FeS/SAM binding site; other site 373994018446 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 373994018447 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 373994018448 iron-sulfur cluster [ion binding]; other site 373994018449 [2Fe-2S] cluster binding site [ion binding]; other site 373994018450 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373994018451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373994018452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 373994018453 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 373994018454 FOG: CBS domain [General function prediction only]; Region: COG0517 373994018455 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 373994018456 PAS domain S-box; Region: sensory_box; TIGR00229 373994018457 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994018458 putative active site [active] 373994018459 heme pocket [chemical binding]; other site 373994018460 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 373994018461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994018462 putative active site [active] 373994018463 heme pocket [chemical binding]; other site 373994018464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373994018465 dimer interface [polypeptide binding]; other site 373994018466 phosphorylation site [posttranslational modification] 373994018467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994018468 ATP binding site [chemical binding]; other site 373994018469 Mg2+ binding site [ion binding]; other site 373994018470 G-X-G motif; other site 373994018471 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373994018472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994018473 active site 373994018474 phosphorylation site [posttranslational modification] 373994018475 intermolecular recognition site; other site 373994018476 dimerization interface [polypeptide binding]; other site 373994018477 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 373994018478 CheB methylesterase; Region: CheB_methylest; pfam01339 373994018479 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 373994018480 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 373994018481 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 373994018482 PAS fold; Region: PAS; pfam00989 373994018483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994018484 putative active site [active] 373994018485 heme pocket [chemical binding]; other site 373994018486 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994018487 PAS domain; Region: PAS_9; pfam13426 373994018488 putative active site [active] 373994018489 heme pocket [chemical binding]; other site 373994018490 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 373994018491 ATP-grasp domain; Region: ATP-grasp_4; cl17255 373994018492 integral membrane protein MviN; Region: mviN; TIGR01695 373994018493 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 373994018494 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 373994018495 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 373994018496 Probable Catalytic site; other site 373994018497 metal-binding site 373994018498 hypothetical protein; Provisional; Region: PRK07208 373994018499 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994018500 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994018501 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994018502 active site 373994018503 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 373994018504 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994018505 active site 373994018506 GNT-I family; Region: GNT-I; pfam03071 373994018507 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994018508 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994018509 active site 373994018510 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 373994018511 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 373994018512 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 373994018513 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 373994018514 Walker A/P-loop; other site 373994018515 ATP binding site [chemical binding]; other site 373994018516 Q-loop/lid; other site 373994018517 ABC transporter signature motif; other site 373994018518 Walker B; other site 373994018519 D-loop; other site 373994018520 H-loop/switch region; other site 373994018521 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 373994018522 putative carbohydrate binding site [chemical binding]; other site 373994018523 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 373994018524 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 373994018525 Sulfate transporter family; Region: Sulfate_transp; pfam00916 373994018526 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 373994018527 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994018528 Ligand Binding Site [chemical binding]; other site 373994018529 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994018530 Ligand Binding Site [chemical binding]; other site 373994018531 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 373994018532 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 373994018533 Sulfate transporter family; Region: Sulfate_transp; pfam00916 373994018534 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 373994018535 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 373994018536 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 373994018537 Sulfate transporter family; Region: Sulfate_transp; pfam00916 373994018538 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 373994018539 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994018540 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994018541 active site 373994018542 ATP binding site [chemical binding]; other site 373994018543 substrate binding site [chemical binding]; other site 373994018544 activation loop (A-loop); other site 373994018545 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 373994018546 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373994018547 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373994018548 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373994018549 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373994018550 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373994018551 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373994018552 active site 373994018553 ATP binding site [chemical binding]; other site 373994018554 substrate binding site [chemical binding]; other site 373994018555 activation loop (A-loop); other site 373994018556 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 373994018557 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994018558 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994018559 Predicted membrane protein [Function unknown]; Region: COG3463 373994018560 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 373994018561 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 373994018562 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 373994018563 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 373994018564 CoA-binding site [chemical binding]; other site 373994018565 ATP-binding [chemical binding]; other site 373994018566 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 373994018567 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 373994018568 active site 373994018569 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 373994018570 active site 373994018571 SAM binding site [chemical binding]; other site 373994018572 homodimer interface [polypeptide binding]; other site 373994018573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373994018574 binding surface 373994018575 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373994018576 TPR motif; other site 373994018577 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994018578 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 373994018579 UbiA prenyltransferase family; Region: UbiA; pfam01040 373994018580 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373994018581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994018582 S-adenosylmethionine binding site [chemical binding]; other site 373994018583 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 373994018584 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 373994018585 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 373994018586 TrkA-N domain; Region: TrkA_N; pfam02254 373994018587 TrkA-C domain; Region: TrkA_C; pfam02080 373994018588 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 373994018589 Precorrin-8X methylmutase; Region: CbiC; pfam02570 373994018590 Repair protein; Region: Repair_PSII; pfam04536 373994018591 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 373994018592 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 373994018593 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 373994018594 Cl- selectivity filter; other site 373994018595 Cl- binding residues [ion binding]; other site 373994018596 pore gating glutamate residue; other site 373994018597 dimer interface [polypeptide binding]; other site 373994018598 H+/Cl- coupling transport residue; other site 373994018599 FOG: CBS domain [General function prediction only]; Region: COG0517 373994018600 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 373994018601 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 373994018602 Ligand Binding Site [chemical binding]; other site 373994018603 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373994018604 Ligand Binding Site [chemical binding]; other site 373994018605 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 373994018606 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 373994018607 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994018608 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994018609 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994018610 GAF domain; Region: GAF; pfam01590 373994018611 PAS domain S-box; Region: sensory_box; TIGR00229 373994018612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373994018613 putative active site [active] 373994018614 heme pocket [chemical binding]; other site 373994018615 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373994018616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 373994018617 dimer interface [polypeptide binding]; other site 373994018618 phosphorylation site [posttranslational modification] 373994018619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994018620 ATP binding site [chemical binding]; other site 373994018621 Mg2+ binding site [ion binding]; other site 373994018622 G-X-G motif; other site 373994018623 Protein of unknown function (DUF561); Region: DUF561; pfam04481 373994018624 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 373994018625 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 373994018626 inhibitor-cofactor binding pocket; inhibition site 373994018627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373994018628 catalytic residue [active] 373994018629 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 373994018630 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 373994018631 active site 373994018632 catalytic residues [active] 373994018633 metal binding site [ion binding]; metal-binding site 373994018634 FOG: WD40 repeat [General function prediction only]; Region: COG2319 373994018635 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 373994018636 structural tetrad; other site 373994018637 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 373994018638 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 373994018639 P-loop, Walker A motif; other site 373994018640 Base recognition motif; other site 373994018641 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 373994018642 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994018643 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 373994018644 dihydrodipicolinate reductase; Provisional; Region: PRK00048 373994018645 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 373994018646 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 373994018647 KGK domain; Region: KGK; pfam08872 373994018648 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 373994018649 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373994018650 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 373994018651 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994018652 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373994018653 protein binding site [polypeptide binding]; other site 373994018654 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 373994018655 putative homodimer interface [polypeptide binding]; other site 373994018656 putative homotetramer interface [polypeptide binding]; other site 373994018657 putative metal binding site [ion binding]; other site 373994018658 putative homodimer-homodimer interface [polypeptide binding]; other site 373994018659 putative allosteric switch controlling residues; other site 373994018660 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 373994018661 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 373994018662 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 373994018663 N-acetyl-D-glucosamine binding site [chemical binding]; other site 373994018664 catalytic residue [active] 373994018665 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 373994018666 NADH(P)-binding; Region: NAD_binding_10; pfam13460 373994018667 NAD(P) binding site [chemical binding]; other site 373994018668 putative active site [active] 373994018669 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 373994018670 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 373994018671 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373994018672 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373994018673 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373994018674 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373994018675 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373994018676 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373994018677 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 373994018678 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373994018679 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373994018680 PBP superfamily domain; Region: PBP_like_2; cl17296 373994018681 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 373994018682 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 373994018683 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 373994018684 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 373994018685 active site 373994018686 SAM binding site [chemical binding]; other site 373994018687 homodimer interface [polypeptide binding]; other site 373994018688 phosphoribulokinase; Provisional; Region: PRK07429 373994018689 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 373994018690 active site 373994018691 hypothetical protein; Reviewed; Region: PRK00024 373994018692 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 373994018693 MPN+ (JAMM) motif; other site 373994018694 Zinc-binding site [ion binding]; other site 373994018695 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 373994018696 Bacterial sugar transferase; Region: Bac_transf; pfam02397 373994018697 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 373994018698 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 373994018699 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 373994018700 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994018701 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994018702 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 373994018703 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 373994018704 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 373994018705 acyl-activating enzyme (AAE) consensus motif; other site 373994018706 AMP binding site [chemical binding]; other site 373994018707 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 373994018708 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 373994018709 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 373994018710 O-Antigen ligase; Region: Wzy_C; pfam04932 373994018711 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994018712 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994018713 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994018714 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373994018715 active site 373994018716 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 373994018717 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 373994018718 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 373994018719 Chain length determinant protein; Region: Wzz; pfam02706 373994018720 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994018721 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 373994018722 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 373994018723 NAD binding site [chemical binding]; other site 373994018724 ATP-grasp domain; Region: ATP-grasp; pfam02222 373994018725 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 373994018726 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 373994018727 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 373994018728 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 373994018729 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 373994018730 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 373994018731 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994018732 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373994018733 Predicted membrane protein [Function unknown]; Region: COG1950 373994018734 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 373994018735 homotrimer interaction site [polypeptide binding]; other site 373994018736 putative active site [active] 373994018737 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 373994018738 ATP-NAD kinase; Region: NAD_kinase; pfam01513 373994018739 NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015 373994018740 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 373994018741 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 373994018742 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 373994018743 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 373994018744 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373994018745 NADH dehydrogenase; Region: NADHdh; cl00469 373994018746 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 373994018747 citrate synthase; Provisional; Region: PRK14036 373994018748 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 373994018749 dimer interface [polypeptide binding]; other site 373994018750 active site 373994018751 citrylCoA binding site [chemical binding]; other site 373994018752 oxalacetate/citrate binding site [chemical binding]; other site 373994018753 coenzyme A binding site [chemical binding]; other site 373994018754 catalytic triad [active] 373994018755 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 373994018756 catalytic core [active] 373994018757 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 373994018758 DHH family; Region: DHH; pfam01368 373994018759 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 373994018760 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 373994018761 active site 373994018762 alanine racemase; Reviewed; Region: alr; PRK00053 373994018763 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 373994018764 active site 373994018765 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373994018766 dimer interface [polypeptide binding]; other site 373994018767 substrate binding site [chemical binding]; other site 373994018768 catalytic residues [active] 373994018769 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 373994018770 Response regulator receiver domain; Region: Response_reg; pfam00072 373994018771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994018772 active site 373994018773 phosphorylation site [posttranslational modification] 373994018774 intermolecular recognition site; other site 373994018775 dimerization interface [polypeptide binding]; other site 373994018776 Response regulator receiver domain; Region: Response_reg; pfam00072 373994018777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994018778 active site 373994018779 phosphorylation site [posttranslational modification] 373994018780 intermolecular recognition site; other site 373994018781 dimerization interface [polypeptide binding]; other site 373994018782 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 373994018783 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994018784 dimerization interface [polypeptide binding]; other site 373994018785 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994018786 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994018787 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373994018788 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373994018789 dimer interface [polypeptide binding]; other site 373994018790 putative CheW interface [polypeptide binding]; other site 373994018791 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373994018792 putative binding surface; other site 373994018793 active site 373994018794 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 373994018795 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 373994018796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373994018797 ATP binding site [chemical binding]; other site 373994018798 Mg2+ binding site [ion binding]; other site 373994018799 G-X-G motif; other site 373994018800 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 373994018801 Response regulator receiver domain; Region: Response_reg; pfam00072 373994018802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373994018803 active site 373994018804 phosphorylation site [posttranslational modification] 373994018805 intermolecular recognition site; other site 373994018806 dimerization interface [polypeptide binding]; other site 373994018807 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373994018808 dimerization interface [polypeptide binding]; other site 373994018809 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 373994018810 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373994018811 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373994018812 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373994018813 dimer interface [polypeptide binding]; other site 373994018814 putative CheW interface [polypeptide binding]; other site 373994018815 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 373994018816 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 373994018817 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 373994018818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373994018819 putative PBP binding loops; other site 373994018820 dimer interface [polypeptide binding]; other site 373994018821 ABC-ATPase subunit interface; other site 373994018822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994018823 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 373994018824 Walker A/P-loop; other site 373994018825 ATP binding site [chemical binding]; other site 373994018826 Q-loop/lid; other site 373994018827 ABC transporter signature motif; other site 373994018828 Walker B; other site 373994018829 D-loop; other site 373994018830 H-loop/switch region; other site 373994018831 YcfA-like protein; Region: YcfA; pfam07927 373994018832 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 373994018833 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994018834 putative active site [active] 373994018835 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 373994018836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994018837 S-adenosylmethionine binding site [chemical binding]; other site 373994018838 Domain of unknown function (DUF427); Region: DUF427; cl00998 373994018839 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 373994018840 aromatic arch; other site 373994018841 DCoH dimer interaction site [polypeptide binding]; other site 373994018842 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 373994018843 DCoH tetramer interaction site [polypeptide binding]; other site 373994018844 substrate binding site [chemical binding]; other site 373994018845 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 373994018846 putative active site [active] 373994018847 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 373994018848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 373994018849 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994018850 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373994018851 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 373994018852 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 373994018853 CHAT domain; Region: CHAT; cl17868 373994018854 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 373994018855 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 373994018856 putative ligand binding site [chemical binding]; other site 373994018857 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 373994018858 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 373994018859 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 373994018860 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 373994018861 Family description; Region: UvrD_C_2; pfam13538 373994018862 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 373994018863 active site 373994018864 Clp protease ATP binding subunit; Region: clpC; CHL00095 373994018865 Clp amino terminal domain; Region: Clp_N; pfam02861 373994018866 Clp amino terminal domain; Region: Clp_N; pfam02861 373994018867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994018868 Walker A motif; other site 373994018869 ATP binding site [chemical binding]; other site 373994018870 Walker B motif; other site 373994018871 arginine finger; other site 373994018872 UvrB/uvrC motif; Region: UVR; pfam02151 373994018873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373994018874 Walker A motif; other site 373994018875 ATP binding site [chemical binding]; other site 373994018876 Walker B motif; other site 373994018877 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 373994018878 Flagellin N-methylase; Region: FliB; pfam03692 373994018879 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 373994018880 Probable transposase; Region: OrfB_IS605; pfam01385 373994018881 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 373994018882 hypothetical protein; Provisional; Region: PRK13686 373994018883 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 373994018884 DHH family; Region: DHH; pfam01368 373994018885 DHHA1 domain; Region: DHHA1; pfam02272 373994018886 asparagine synthetase B; Provisional; Region: asnB; PRK09431 373994018887 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 373994018888 active site 373994018889 dimer interface [polypeptide binding]; other site 373994018890 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 373994018891 Ligand Binding Site [chemical binding]; other site 373994018892 Molecular Tunnel; other site 373994018893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373994018894 S-adenosylmethionine binding site [chemical binding]; other site 373994018895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 373994018896 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 373994018897 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 373994018898 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 373994018899 NodB motif; other site 373994018900 active site 373994018901 catalytic site [active] 373994018902 metal binding site [ion binding]; metal-binding site 373994018903 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 373994018904 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994018905 non-specific DNA binding site [nucleotide binding]; other site 373994018906 salt bridge; other site 373994018907 sequence-specific DNA binding site [nucleotide binding]; other site 373994018908 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 373994018909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373994018910 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 373994018911 MltA specific insert domain; Region: MltA; pfam03562 373994018912 3D domain; Region: 3D; pfam06725 373994018913 hypothetical protein; Validated; Region: PRK07413 373994018914 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 373994018915 homodimer interface [polypeptide binding]; other site 373994018916 Walker A motif; other site 373994018917 ATP binding site [chemical binding]; other site 373994018918 hydroxycobalamin binding site [chemical binding]; other site 373994018919 Walker B motif; other site 373994018920 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 373994018921 Walker A motif; other site 373994018922 homodimer interface [polypeptide binding]; other site 373994018923 ATP binding site [chemical binding]; other site 373994018924 hydroxycobalamin binding site [chemical binding]; other site 373994018925 Walker B motif; other site 373994018926 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 373994018927 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 373994018928 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 373994018929 tetramer (dimer of dimers) interface [polypeptide binding]; other site 373994018930 active site 373994018931 dimer interface [polypeptide binding]; other site 373994018932 S-layer homology domain; Region: SLH; pfam00395 373994018933 S-layer homology domain; Region: SLH; pfam00395 373994018934 S-layer homology domain; Region: SLH; pfam00395 373994018935 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 373994018936 O-Antigen ligase; Region: Wzy_C; pfam04932 373994018937 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 373994018938 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 373994018939 TPP-binding site; other site 373994018940 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 373994018941 PYR/PP interface [polypeptide binding]; other site 373994018942 dimer interface [polypeptide binding]; other site 373994018943 TPP binding site [chemical binding]; other site 373994018944 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 373994018945 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 373994018946 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 373994018947 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 373994018948 TM2 domain; Region: TM2; cl00984 373994018949 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 373994018950 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 373994018951 dimer interface [polypeptide binding]; other site 373994018952 putative functional site; other site 373994018953 putative MPT binding site; other site 373994018954 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 373994018955 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 373994018956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373994018957 motif II; other site 373994018958 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 373994018959 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373994018960 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373994018961 CHAT domain; Region: CHAT; pfam12770 373994018962 GUN4-like; Region: GUN4; pfam05419 373994018963 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 373994018964 PLD-like domain; Region: PLDc_2; pfam13091 373994018965 putative active site [active] 373994018966 catalytic site [active] 373994018967 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 373994018968 PLD-like domain; Region: PLDc_2; pfam13091 373994018969 putative active site [active] 373994018970 catalytic site [active] 373994018971 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 373994018972 Helix-hairpin-helix motif; Region: HHH; pfam00633 373994018973 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 373994018974 Domain of unknown function DUF11; Region: DUF11; cl17728 373994018975 conserved repeat domain; Region: B_ant_repeat; TIGR01451 373994018976 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 373994018977 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 373994018978 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 373994018979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373994018980 Zn2+ binding site [ion binding]; other site 373994018981 Mg2+ binding site [ion binding]; other site 373994018982 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 373994018983 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 373994018984 Dehydroquinase class II; Region: DHquinase_II; pfam01220 373994018985 trimer interface [polypeptide binding]; other site 373994018986 active site 373994018987 dimer interface [polypeptide binding]; other site 373994018988 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 373994018989 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 373994018990 active site 373994018991 interdomain interaction site; other site 373994018992 putative metal-binding site [ion binding]; other site 373994018993 nucleotide binding site [chemical binding]; other site 373994018994 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 373994018995 domain I; other site 373994018996 phosphate binding site [ion binding]; other site 373994018997 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 373994018998 domain II; other site 373994018999 domain III; other site 373994019000 nucleotide binding site [chemical binding]; other site 373994019001 DNA binding groove [nucleotide binding] 373994019002 catalytic site [active] 373994019003 domain IV; other site 373994019004 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 373994019005 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 373994019006 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 373994019007 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 373994019008 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 373994019009 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373994019010 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994019011 active site 373994019012 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994019013 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 373994019014 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 373994019015 putative ABC transporter; Region: ycf24; CHL00085 373994019016 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 373994019017 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 373994019018 Walker A/P-loop; other site 373994019019 ATP binding site [chemical binding]; other site 373994019020 Q-loop/lid; other site 373994019021 ABC transporter signature motif; other site 373994019022 Walker B; other site 373994019023 D-loop; other site 373994019024 H-loop/switch region; other site 373994019025 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 373994019026 FeS assembly protein SufD; Region: sufD; TIGR01981 373994019027 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 373994019028 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 373994019029 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373994019030 catalytic residue [active] 373994019031 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 373994019032 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 373994019033 CAAX protease self-immunity; Region: Abi; pfam02517 373994019034 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 373994019035 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 373994019036 metal-binding site [ion binding] 373994019037 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373994019038 Soluble P-type ATPase [General function prediction only]; Region: COG4087 373994019039 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 373994019040 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 373994019041 phosphopeptide binding site; other site 373994019042 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 373994019043 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 373994019044 putative NAD(P) binding site [chemical binding]; other site 373994019045 putative active site [active] 373994019046 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 373994019047 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 373994019048 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 373994019049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994019050 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 373994019051 putative hydrophobic ligand binding site [chemical binding]; other site 373994019052 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 373994019053 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373994019054 catalytic loop [active] 373994019055 iron binding site [ion binding]; other site 373994019056 cobyric acid synthase; Provisional; Region: PRK00784 373994019057 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994019058 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373994019059 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 373994019060 catalytic triad [active] 373994019061 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 373994019062 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994019063 active site 373994019064 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 373994019065 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 373994019066 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373994019067 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373994019068 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 373994019069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994019070 active site 373994019071 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373994019072 hypothetical protein; Provisional; Region: PRK07208 373994019073 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373994019074 hydroxyglutarate oxidase; Provisional; Region: PRK11728 373994019075 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373994019076 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 373994019077 Probable Catalytic site; other site 373994019078 metal-binding site 373994019079 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 373994019080 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 373994019081 catalytic triad [active] 373994019082 ABC-2 type transporter; Region: ABC2_membrane; cl17235 373994019083 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 373994019084 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 373994019085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373994019086 Walker A/P-loop; other site 373994019087 ATP binding site [chemical binding]; other site 373994019088 Q-loop/lid; other site 373994019089 ABC transporter signature motif; other site 373994019090 Walker B; other site 373994019091 D-loop; other site 373994019092 H-loop/switch region; other site 373994019093 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373994019094 Tetratricopeptide repeat; Region: TPR_10; cl17452 373994019095 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 373994019096 active site 373994019097 catalytic residues [active] 373994019098 metal binding site [ion binding]; metal-binding site 373994019099 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373994019100 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373994019101 protein binding site [polypeptide binding]; other site 373994019102 Competence protein CoiA-like family; Region: CoiA; cl11541 373994019103 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 373994019104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373994019105 non-specific DNA binding site [nucleotide binding]; other site 373994019106 salt bridge; other site 373994019107 sequence-specific DNA binding site [nucleotide binding]; other site 373994019108 large terminase protein; Provisional; Region: 17; PHA02533 373994019109 Terminase-like family; Region: Terminase_6; pfam03237 373994019110 T5orf172 domain; Region: T5orf172; pfam10544 373994019111 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 373994019112 nucleotide binding site [chemical binding]; other site 373994019113 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 373994019114 DNA repair helicase (rad3); Region: rad3; TIGR00604 373994019115 Phage replication protein CRI; Region: Phage_CRI; pfam05144