-- dump date   	20140620_040717
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
718255000001	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
718255000002	dimerization interface [polypeptide binding]; other site
718255000003	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255000004	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255000005	dimer interface [polypeptide binding]; other site
718255000006	putative CheW interface [polypeptide binding]; other site
718255000007	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
718255000008	Helix-turn-helix domain; Region: HTH_17; pfam12728
718255000009	Integrase core domain; Region: rve; pfam00665
718255000010	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
718255000011	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
718255000012	CHC2 zinc finger; Region: zf-CHC2; cl17510
718255000013	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
718255000014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255000015	ATP binding site [chemical binding]; other site
718255000016	Mg2+ binding site [ion binding]; other site
718255000017	G-X-G motif; other site
718255000018	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
718255000019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255000020	active site
718255000021	phosphorylation site [posttranslational modification]
718255000022	intermolecular recognition site; other site
718255000023	dimerization interface [polypeptide binding]; other site
718255000024	LytTr DNA-binding domain; Region: LytTR; smart00850
718255000025	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
718255000026	intermolecular recognition site; other site
718255000027	active site
718255000028	dimerization interface [polypeptide binding]; other site
718255000029	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
718255000030	Uncharacterized conserved protein [Function unknown]; Region: COG5361
718255000031	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
718255000032	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
718255000033	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
718255000034	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
718255000035	Beta propeller domain; Region: Beta_propel; pfam09826
718255000036	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
718255000037	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
718255000038	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
718255000039	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
718255000040	active site
718255000041	HIGH motif; other site
718255000042	dimer interface [polypeptide binding]; other site
718255000043	KMSKS motif; other site
718255000044	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718255000045	RNA binding surface [nucleotide binding]; other site
718255000046	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718255000047	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718255000048	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255000049	DNA binding residues [nucleotide binding]
718255000050	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
718255000051	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255000052	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
718255000053	active site
718255000054	motif I; other site
718255000055	motif II; other site
718255000056	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255000057	BioY family; Region: BioY; pfam02632
718255000058	biotin synthase; Region: bioB; TIGR00433
718255000059	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255000060	FeS/SAM binding site; other site
718255000061	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
718255000062	AAA domain; Region: AAA_26; pfam13500
718255000063	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
718255000064	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
718255000065	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
718255000066	inhibitor-cofactor binding pocket; inhibition site
718255000067	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255000068	catalytic residue [active]
718255000069	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
718255000070	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
718255000071	dimer interface [polypeptide binding]; other site
718255000072	PYR/PP interface [polypeptide binding]; other site
718255000073	TPP binding site [chemical binding]; other site
718255000074	substrate binding site [chemical binding]; other site
718255000075	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
718255000076	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
718255000077	TPP-binding site [chemical binding]; other site
718255000078	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
718255000079	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
718255000080	2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179
718255000081	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718255000082	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
718255000083	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
718255000084	transmembrane helices; other site
718255000085	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
718255000086	EamA-like transporter family; Region: EamA; pfam00892
718255000087	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
718255000088	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
718255000089	active site
718255000090	catalytic site [active]
718255000091	metal binding site [ion binding]; metal-binding site
718255000092	dimer interface [polypeptide binding]; other site
718255000093	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
718255000094	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
718255000095	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
718255000096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718255000097	putative substrate translocation pore; other site
718255000098	PBP superfamily domain; Region: PBP_like_2; cl17296
718255000099	PBP superfamily domain; Region: PBP_like_2; cl17296
718255000100	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
718255000101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255000102	dimer interface [polypeptide binding]; other site
718255000103	conserved gate region; other site
718255000104	putative PBP binding loops; other site
718255000105	ABC-ATPase subunit interface; other site
718255000106	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
718255000107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255000108	dimer interface [polypeptide binding]; other site
718255000109	conserved gate region; other site
718255000110	putative PBP binding loops; other site
718255000111	ABC-ATPase subunit interface; other site
718255000112	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
718255000113	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
718255000114	Walker A/P-loop; other site
718255000115	ATP binding site [chemical binding]; other site
718255000116	Q-loop/lid; other site
718255000117	ABC transporter signature motif; other site
718255000118	Walker B; other site
718255000119	D-loop; other site
718255000120	H-loop/switch region; other site
718255000121	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
718255000122	PhoU domain; Region: PhoU; pfam01895
718255000123	PhoU domain; Region: PhoU; pfam01895
718255000124	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
718255000125	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
718255000126	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
718255000127	PhoU domain; Region: PhoU; pfam01895
718255000128	PhoU domain; Region: PhoU; pfam01895
718255000129	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255000130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255000131	active site
718255000132	phosphorylation site [posttranslational modification]
718255000133	intermolecular recognition site; other site
718255000134	dimerization interface [polypeptide binding]; other site
718255000135	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255000136	DNA binding site [nucleotide binding]
718255000137	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255000138	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255000139	dimer interface [polypeptide binding]; other site
718255000140	phosphorylation site [posttranslational modification]
718255000141	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255000142	ATP binding site [chemical binding]; other site
718255000143	Mg2+ binding site [ion binding]; other site
718255000144	G-X-G motif; other site
718255000145	SWIM zinc finger; Region: SWIM; pfam04434
718255000146	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
718255000147	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
718255000148	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718255000149	ATP binding site [chemical binding]; other site
718255000150	putative Mg++ binding site [ion binding]; other site
718255000151	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718255000152	nucleotide binding region [chemical binding]; other site
718255000153	ATP-binding site [chemical binding]; other site
718255000154	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
718255000155	Domain of unknown function DUF; Region: DUF204; pfam02659
718255000156	Domain of unknown function DUF; Region: DUF204; pfam02659
718255000157	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
718255000158	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
718255000159	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
718255000160	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
718255000161	Double zinc ribbon; Region: DZR; pfam12773
718255000162	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
718255000163	glycerol kinase; Provisional; Region: glpK; PRK00047
718255000164	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
718255000165	N- and C-terminal domain interface [polypeptide binding]; other site
718255000166	active site
718255000167	MgATP binding site [chemical binding]; other site
718255000168	catalytic site [active]
718255000169	metal binding site [ion binding]; metal-binding site
718255000170	glycerol binding site [chemical binding]; other site
718255000171	homotetramer interface [polypeptide binding]; other site
718255000172	homodimer interface [polypeptide binding]; other site
718255000173	FBP binding site [chemical binding]; other site
718255000174	protein IIAGlc interface [polypeptide binding]; other site
718255000175	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
718255000176	amphipathic channel; other site
718255000177	Asn-Pro-Ala signature motifs; other site
718255000178	Predicted dehydrogenase [General function prediction only]; Region: COG0579
718255000179	hydroxyglutarate oxidase; Provisional; Region: PRK11728
718255000180	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
718255000181	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
718255000182	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718255000183	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718255000184	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
718255000185	Protein of unknown function (DUF1667); Region: DUF1667; pfam07892
718255000186	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255000187	Cytokine receptor motif; other site
718255000188	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
718255000189	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
718255000190	active site
718255000191	HIGH motif; other site
718255000192	KMSKS motif; other site
718255000193	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
718255000194	tRNA binding surface [nucleotide binding]; other site
718255000195	anticodon binding site; other site
718255000196	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
718255000197	dimer interface [polypeptide binding]; other site
718255000198	putative tRNA-binding site [nucleotide binding]; other site
718255000199	phosphodiesterase; Provisional; Region: PRK12704
718255000200	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
718255000201	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
718255000202	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
718255000203	active site
718255000204	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
718255000205	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
718255000206	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255000207	FeS/SAM binding site; other site
718255000208	Cache domain; Region: Cache_1; pfam02743
718255000209	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
718255000210	HAMP domain; Region: HAMP; pfam00672
718255000211	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255000212	dimer interface [polypeptide binding]; other site
718255000213	putative CheW interface [polypeptide binding]; other site
718255000214	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
718255000215	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255000216	S-adenosylmethionine binding site [chemical binding]; other site
718255000217	stage II sporulation protein D; Region: spore_II_D; TIGR02870
718255000218	Stage II sporulation protein; Region: SpoIID; pfam08486
718255000219	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
718255000220	Peptidase family M23; Region: Peptidase_M23; pfam01551
718255000221	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255000222	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255000223	metal binding site [ion binding]; metal-binding site
718255000224	active site
718255000225	I-site; other site
718255000226	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
718255000227	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
718255000228	ATP binding site [chemical binding]; other site
718255000229	Mg++ binding site [ion binding]; other site
718255000230	motif III; other site
718255000231	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718255000232	nucleotide binding region [chemical binding]; other site
718255000233	ATP-binding site [chemical binding]; other site
718255000234	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
718255000235	RNA binding site [nucleotide binding]; other site
718255000236	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144
718255000237	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255000238	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255000239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255000240	active site
718255000241	phosphorylation site [posttranslational modification]
718255000242	intermolecular recognition site; other site
718255000243	dimerization interface [polypeptide binding]; other site
718255000244	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255000245	DNA binding site [nucleotide binding]
718255000246	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
718255000247	Rubredoxin; Region: Rubredoxin; pfam00301
718255000248	iron binding site [ion binding]; other site
718255000249	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
718255000250	Rubrerythrin [Energy production and conversion]; Region: COG1592
718255000251	diiron binding motif [ion binding]; other site
718255000252	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
718255000253	metal binding site 2 [ion binding]; metal-binding site
718255000254	putative DNA binding helix; other site
718255000255	metal binding site 1 [ion binding]; metal-binding site
718255000256	dimer interface [polypeptide binding]; other site
718255000257	structural Zn2+ binding site [ion binding]; other site
718255000258	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
718255000259	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
718255000260	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
718255000261	nucleoside/Zn binding site; other site
718255000262	dimer interface [polypeptide binding]; other site
718255000263	catalytic motif [active]
718255000264	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
718255000265	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255000266	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
718255000267	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
718255000268	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
718255000269	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
718255000270	transmembrane helices; other site
718255000271	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
718255000272	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255000273	active site
718255000274	Int/Topo IB signature motif; other site
718255000275	DNA binding site [nucleotide binding]
718255000276	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
718255000277	putative active site [active]
718255000278	6-phosphofructokinase; Provisional; Region: PRK03202
718255000279	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
718255000280	active site
718255000281	ADP/pyrophosphate binding site [chemical binding]; other site
718255000282	dimerization interface [polypeptide binding]; other site
718255000283	allosteric effector site; other site
718255000284	fructose-1,6-bisphosphate binding site; other site
718255000285	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
718255000286	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255000287	Walker A motif; other site
718255000288	ATP binding site [chemical binding]; other site
718255000289	Walker B motif; other site
718255000290	arginine finger; other site
718255000291	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
718255000292	hypothetical protein; Validated; Region: PRK00153
718255000293	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255000294	active site
718255000295	DNA binding site [nucleotide binding]
718255000296	Int/Topo IB signature motif; other site
718255000297	Global regulator protein family; Region: CsrA; pfam02599
718255000298	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
718255000299	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
718255000300	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
718255000301	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
718255000302	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718255000303	catalytic core [active]
718255000304	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
718255000305	active site
718255000306	catalytic site [active]
718255000307	substrate binding site [chemical binding]; other site
718255000308	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
718255000309	Acylphosphatase; Region: Acylphosphatase; pfam00708
718255000310	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
718255000311	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718255000312	substrate binding pocket [chemical binding]; other site
718255000313	membrane-bound complex binding site; other site
718255000314	hinge residues; other site
718255000315	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255000316	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255000317	dimer interface [polypeptide binding]; other site
718255000318	phosphorylation site [posttranslational modification]
718255000319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255000320	ATP binding site [chemical binding]; other site
718255000321	Mg2+ binding site [ion binding]; other site
718255000322	G-X-G motif; other site
718255000323	Response regulator receiver domain; Region: Response_reg; pfam00072
718255000324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255000325	active site
718255000326	phosphorylation site [posttranslational modification]
718255000327	intermolecular recognition site; other site
718255000328	dimerization interface [polypeptide binding]; other site
718255000329	Uncharacterized conserved protein [Function unknown]; Region: COG1284
718255000330	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
718255000331	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
718255000332	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
718255000333	substrate binding site; other site
718255000334	dimerization interface; other site
718255000335	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
718255000336	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
718255000337	synthetase active site [active]
718255000338	NTP binding site [chemical binding]; other site
718255000339	metal binding site [ion binding]; metal-binding site
718255000340	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
718255000341	putative catalytic site [active]
718255000342	putative phosphate binding site [ion binding]; other site
718255000343	putative metal binding site [ion binding]; other site
718255000344	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
718255000345	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
718255000346	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
718255000347	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255000348	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
718255000349	C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156
718255000350	putative homodimer interface [polypeptide binding]; other site
718255000351	putative homotetramer interface [polypeptide binding]; other site
718255000352	putative allosteric switch controlling residues; other site
718255000353	putative metal binding site [ion binding]; other site
718255000354	putative homodimer-homodimer interface [polypeptide binding]; other site
718255000355	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
718255000356	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718255000357	metal-binding site [ion binding]
718255000358	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718255000359	Soluble P-type ATPase [General function prediction only]; Region: COG4087
718255000360	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718255000361	metal-binding site [ion binding]
718255000362	recombination protein RecR; Reviewed; Region: recR; PRK00076
718255000363	RecR protein; Region: RecR; pfam02132
718255000364	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
718255000365	putative active site [active]
718255000366	putative metal-binding site [ion binding]; other site
718255000367	tetramer interface [polypeptide binding]; other site
718255000368	transketolase; Reviewed; Region: PRK05899
718255000369	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
718255000370	TPP-binding site [chemical binding]; other site
718255000371	dimer interface [polypeptide binding]; other site
718255000372	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
718255000373	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
718255000374	PYR/PP interface [polypeptide binding]; other site
718255000375	dimer interface [polypeptide binding]; other site
718255000376	TPP binding site [chemical binding]; other site
718255000377	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
718255000378	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718255000379	Colicin V production protein; Region: Colicin_V; pfam02674
718255000380	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
718255000381	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718255000382	NlpC/P60 family; Region: NLPC_P60; cl17555
718255000383	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
718255000384	putative active site pocket [active]
718255000385	dimerization interface [polypeptide binding]; other site
718255000386	putative catalytic residue [active]
718255000387	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
718255000388	AAA-like domain; Region: AAA_10; pfam12846
718255000389	Domain of unknown function DUF87; Region: DUF87; pfam01935
718255000390	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718255000391	cofactor binding site; other site
718255000392	DNA binding site [nucleotide binding]
718255000393	substrate interaction site [chemical binding]; other site
718255000394	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718255000395	SpoVG; Region: SpoVG; cl00915
718255000396	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
718255000397	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
718255000398	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255000399	S-adenosylmethionine binding site [chemical binding]; other site
718255000400	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
718255000401	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
718255000402	generic binding surface II; other site
718255000403	generic binding surface I; other site
718255000404	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255000405	Zn2+ binding site [ion binding]; other site
718255000406	Mg2+ binding site [ion binding]; other site
718255000407	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
718255000408	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
718255000409	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
718255000410	protein binding site [polypeptide binding]; other site
718255000411	MutS domain III; Region: MutS_III; pfam05192
718255000412	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
718255000413	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
718255000414	Walker A/P-loop; other site
718255000415	ATP binding site [chemical binding]; other site
718255000416	Q-loop/lid; other site
718255000417	ABC transporter signature motif; other site
718255000418	Walker B; other site
718255000419	D-loop; other site
718255000420	H-loop/switch region; other site
718255000421	Smr domain; Region: Smr; pfam01713
718255000422	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255000423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255000424	active site
718255000425	phosphorylation site [posttranslational modification]
718255000426	intermolecular recognition site; other site
718255000427	dimerization interface [polypeptide binding]; other site
718255000428	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255000429	DNA binding site [nucleotide binding]
718255000430	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255000431	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255000432	dimerization interface [polypeptide binding]; other site
718255000433	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255000434	dimer interface [polypeptide binding]; other site
718255000435	phosphorylation site [posttranslational modification]
718255000436	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255000437	ATP binding site [chemical binding]; other site
718255000438	Mg2+ binding site [ion binding]; other site
718255000439	G-X-G motif; other site
718255000440	Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958
718255000441	TfoX N-terminal domain; Region: TfoX_N; pfam04993
718255000442	TIGR04076 family protein; Region: TIGR04076
718255000443	Protein of unknown function (DUF1706); Region: DUF1706; cl01748
718255000444	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
718255000445	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
718255000446	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
718255000447	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718255000448	RNA binding surface [nucleotide binding]; other site
718255000449	30S ribosomal protein S11; Validated; Region: PRK05309
718255000450	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
718255000451	30S ribosomal protein S13; Region: bact_S13; TIGR03631
718255000452	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
718255000453	rRNA binding site [nucleotide binding]; other site
718255000454	predicted 30S ribosome binding site; other site
718255000455	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
718255000456	RNA binding site [nucleotide binding]; other site
718255000457	adenylate kinase; Reviewed; Region: adk; PRK00279
718255000458	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
718255000459	AMP-binding site [chemical binding]; other site
718255000460	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
718255000461	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
718255000462	SecY translocase; Region: SecY; pfam00344
718255000463	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
718255000464	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30_like; cd00355
718255000465	23S rRNA binding site - archaea [nucleotide binding]; other site
718255000466	23S rRNA binding site - prokaryotes [nucleotide binding]; other site
718255000467	5S rRNA binding site - archaea; other site
718255000468	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
718255000469	5S rRNA interface [nucleotide binding]; other site
718255000470	L27 interface [polypeptide binding]; other site
718255000471	23S rRNA interface [nucleotide binding]; other site
718255000472	L5 interface [polypeptide binding]; other site
718255000473	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
718255000474	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
718255000475	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
718255000476	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
718255000477	Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198
718255000478	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
718255000479	RNA binding site [nucleotide binding]; other site
718255000480	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
718255000481	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
718255000482	putative translocon interaction site; other site
718255000483	23S rRNA interface [nucleotide binding]; other site
718255000484	signal recognition particle (SRP54) interaction site; other site
718255000485	L23 interface [polypeptide binding]; other site
718255000486	trigger factor interaction site; other site
718255000487	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
718255000488	23S rRNA interface [nucleotide binding]; other site
718255000489	5S rRNA interface [nucleotide binding]; other site
718255000490	putative antibiotic binding site [chemical binding]; other site
718255000491	L25 interface [polypeptide binding]; other site
718255000492	L27 interface [polypeptide binding]; other site
718255000493	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
718255000494	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
718255000495	G-X-X-G motif; other site
718255000496	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
718255000497	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
718255000498	protein-rRNA interface [nucleotide binding]; other site
718255000499	putative translocon binding site; other site
718255000500	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
718255000501	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
718255000502	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
718255000503	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
718255000504	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
718255000505	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
718255000506	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
718255000507	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
718255000508	TrkA-N domain; Region: TrkA_N; pfam02254
718255000509	TrkA-C domain; Region: TrkA_C; pfam02080
718255000510	TrkA-N domain; Region: TrkA_N; pfam02254
718255000511	TrkA-C domain; Region: TrkA_C; pfam02080
718255000512	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
718255000513	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
718255000514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255000515	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
718255000516	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
718255000517	Cl binding site [ion binding]; other site
718255000518	oligomer interface [polypeptide binding]; other site
718255000519	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
718255000520	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255000521	Coenzyme A binding pocket [chemical binding]; other site
718255000522	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
718255000523	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255000524	motif II; other site
718255000525	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
718255000526	thiamine phosphate binding site [chemical binding]; other site
718255000527	active site
718255000528	pyrophosphate binding site [ion binding]; other site
718255000529	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
718255000530	substrate binding site [chemical binding]; other site
718255000531	multimerization interface [polypeptide binding]; other site
718255000532	ATP binding site [chemical binding]; other site
718255000533	TraX protein; Region: TraX; pfam05857
718255000534	conjugal transfer protein TrbP; Provisional; Region: PRK13882
718255000535	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
718255000536	active site
718255000537	dimer interface [polypeptide binding]; other site
718255000538	Cache domain; Region: Cache_1; pfam02743
718255000539	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255000540	dimerization interface [polypeptide binding]; other site
718255000541	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255000542	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255000543	dimer interface [polypeptide binding]; other site
718255000544	putative CheW interface [polypeptide binding]; other site
718255000545	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
718255000546	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718255000547	NAD(P) binding site [chemical binding]; other site
718255000548	active site
718255000549	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
718255000550	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234
718255000551	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
718255000552	active site
718255000553	catalytic site [active]
718255000554	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
718255000555	intersubunit interface [polypeptide binding]; other site
718255000556	active site
718255000557	Zn2+ binding site [ion binding]; other site
718255000558	putative pectinesterase; Region: PLN02432; cl01911
718255000559	CAAX protease self-immunity; Region: Abi; pfam02517
718255000560	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
718255000561	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
718255000562	EamA-like transporter family; Region: EamA; pfam00892
718255000563	EamA-like transporter family; Region: EamA; pfam00892
718255000564	elongation factor Tu; Reviewed; Region: PRK00049
718255000565	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
718255000566	G1 box; other site
718255000567	GEF interaction site [polypeptide binding]; other site
718255000568	GTP/Mg2+ binding site [chemical binding]; other site
718255000569	Switch I region; other site
718255000570	G2 box; other site
718255000571	G3 box; other site
718255000572	Switch II region; other site
718255000573	G4 box; other site
718255000574	G5 box; other site
718255000575	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
718255000576	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
718255000577	Antibiotic Binding Site [chemical binding]; other site
718255000578	30S ribosomal protein S7; Validated; Region: PRK05302
718255000579	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
718255000580	S17 interaction site [polypeptide binding]; other site
718255000581	S8 interaction site; other site
718255000582	16S rRNA interaction site [nucleotide binding]; other site
718255000583	streptomycin interaction site [chemical binding]; other site
718255000584	23S rRNA interaction site [nucleotide binding]; other site
718255000585	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
718255000586	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
718255000587	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
718255000588	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
718255000589	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
718255000590	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
718255000591	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
718255000592	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
718255000593	G-loop; other site
718255000594	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
718255000595	DNA binding site [nucleotide binding]
718255000596	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
718255000597	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
718255000598	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
718255000599	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
718255000600	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
718255000601	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
718255000602	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
718255000603	RPB1 interaction site [polypeptide binding]; other site
718255000604	RPB10 interaction site [polypeptide binding]; other site
718255000605	RPB11 interaction site [polypeptide binding]; other site
718255000606	RPB3 interaction site [polypeptide binding]; other site
718255000607	RPB12 interaction site [polypeptide binding]; other site
718255000608	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
718255000609	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
718255000610	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
718255000611	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718255000612	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255000613	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
718255000614	catalytic residues [active]
718255000615	catalytic nucleophile [active]
718255000616	Recombinase; Region: Recombinase; pfam07508
718255000617	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255000618	AAA domain; Region: AAA_22; pfam13401
718255000619	Abi-like protein; Region: Abi_2; pfam07751
718255000620	Mrr N-terminal domain; Region: Mrr_N; pfam14338
718255000621	Restriction endonuclease; Region: Mrr_cat; pfam04471
718255000622	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
718255000623	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255000624	Walker A motif; other site
718255000625	ATP binding site [chemical binding]; other site
718255000626	Walker B motif; other site
718255000627	SIR2-like domain; Region: SIR2_2; pfam13289
718255000628	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
718255000629	AAA domain; Region: AAA_21; pfam13304
718255000630	TIGR02646 family protein; Region: TIGR02646
718255000631	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255000632	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255000633	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
718255000634	Walker A/P-loop; other site
718255000635	ATP binding site [chemical binding]; other site
718255000636	Q-loop/lid; other site
718255000637	ABC transporter signature motif; other site
718255000638	Walker B; other site
718255000639	D-loop; other site
718255000640	H-loop/switch region; other site
718255000641	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
718255000642	putative active site [active]
718255000643	nucleotide binding site [chemical binding]; other site
718255000644	nudix motif; other site
718255000645	putative metal binding site [ion binding]; other site
718255000646	trigger factor; Provisional; Region: tig; PRK01490
718255000647	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
718255000648	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
718255000649	Clp protease; Region: CLP_protease; pfam00574
718255000650	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
718255000651	oligomer interface [polypeptide binding]; other site
718255000652	active site residues [active]
718255000653	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
718255000654	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
718255000655	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255000656	Walker A motif; other site
718255000657	ATP binding site [chemical binding]; other site
718255000658	Walker B motif; other site
718255000659	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
718255000660	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
718255000661	G1 box; other site
718255000662	GTP/Mg2+ binding site [chemical binding]; other site
718255000663	Switch I region; other site
718255000664	G2 box; other site
718255000665	G3 box; other site
718255000666	Switch II region; other site
718255000667	G4 box; other site
718255000668	G5 box; other site
718255000669	carbamate kinase; Reviewed; Region: PRK12686
718255000670	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
718255000671	putative substrate binding site [chemical binding]; other site
718255000672	nucleotide binding site [chemical binding]; other site
718255000673	nucleotide binding site [chemical binding]; other site
718255000674	homodimer interface [polypeptide binding]; other site
718255000675	pyruvate kinase; Provisional; Region: PRK06354
718255000676	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
718255000677	domain interfaces; other site
718255000678	active site
718255000679	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
718255000680	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718255000681	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255000682	Cupin domain; Region: Cupin_2; pfam07883
718255000683	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255000684	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255000685	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255000686	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
718255000687	N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754
718255000688	catalytic domain interface [polypeptide binding]; other site
718255000689	homodimer interface [polypeptide binding]; other site
718255000690	putative active site [active]
718255000691	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255000692	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255000693	DNA binding site [nucleotide binding]
718255000694	domain linker motif; other site
718255000695	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
718255000696	dimerization interface [polypeptide binding]; other site
718255000697	ligand binding site [chemical binding]; other site
718255000698	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
718255000699	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
718255000700	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
718255000701	Protein export membrane protein; Region: SecD_SecF; cl14618
718255000702	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
718255000703	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
718255000704	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718255000705	active site
718255000706	HIGH motif; other site
718255000707	nucleotide binding site [chemical binding]; other site
718255000708	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
718255000709	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
718255000710	active site
718255000711	KMSKS motif; other site
718255000712	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
718255000713	tRNA binding surface [nucleotide binding]; other site
718255000714	anticodon binding site; other site
718255000715	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
718255000716	Protein of unknown function (DUF342); Region: DUF342; pfam03961
718255000717	Tetratricopeptide repeat; Region: TPR_16; pfam13432
718255000718	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718255000719	binding surface
718255000720	TPR motif; other site
718255000721	Tetratricopeptide repeat; Region: TPR_12; pfam13424
718255000722	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718255000723	binding surface
718255000724	TPR motif; other site
718255000725	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
718255000726	anti sigma factor interaction site; other site
718255000727	regulatory phosphorylation site [posttranslational modification]; other site
718255000728	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
718255000729	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255000730	ATP binding site [chemical binding]; other site
718255000731	Mg2+ binding site [ion binding]; other site
718255000732	G-X-G motif; other site
718255000733	sporulation sigma factor SigF; Validated; Region: PRK05572
718255000734	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718255000735	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
718255000736	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255000737	DNA binding residues [nucleotide binding]
718255000738	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
718255000739	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255000740	motif II; other site
718255000741	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
718255000742	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255000743	Zn2+ binding site [ion binding]; other site
718255000744	Mg2+ binding site [ion binding]; other site
718255000745	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
718255000746	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
718255000747	ligand binding site [chemical binding]; other site
718255000748	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
718255000749	hybrid cluster protein; Provisional; Region: PRK05290
718255000750	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718255000751	ACS interaction site; other site
718255000752	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
718255000753	hybrid metal cluster; other site
718255000754	PAS domain; Region: PAS_9; pfam13426
718255000755	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
718255000756	GAF domain; Region: GAF_3; pfam13492
718255000757	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255000758	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255000759	metal binding site [ion binding]; metal-binding site
718255000760	active site
718255000761	I-site; other site
718255000762	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
718255000763	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
718255000764	active site
718255000765	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
718255000766	Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194
718255000767	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
718255000768	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
718255000769	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
718255000770	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255000771	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255000772	catalytic residues [active]
718255000773	catalytic nucleophile [active]
718255000774	Recombinase; Region: Recombinase; pfam07508
718255000775	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255000776	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
718255000777	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
718255000778	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
718255000779	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
718255000780	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
718255000781	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
718255000782	putative dimer interface [polypeptide binding]; other site
718255000783	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
718255000784	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255000785	dimerization interface [polypeptide binding]; other site
718255000786	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255000787	dimer interface [polypeptide binding]; other site
718255000788	phosphorylation site [posttranslational modification]
718255000789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255000790	ATP binding site [chemical binding]; other site
718255000791	Mg2+ binding site [ion binding]; other site
718255000792	G-X-G motif; other site
718255000793	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718255000794	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255000795	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
718255000796	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255000797	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
718255000798	Cupin domain; Region: Cupin_2; pfam07883
718255000799	Helix-turn-helix domain; Region: HTH_18; pfam12833
718255000800	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255000801	beta-phosphoglucomutase; Region: bPGM; TIGR01990
718255000802	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255000803	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718255000804	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718255000805	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255000806	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255000807	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
718255000808	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
718255000809	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255000810	Walker A/P-loop; other site
718255000811	ATP binding site [chemical binding]; other site
718255000812	Q-loop/lid; other site
718255000813	ABC transporter signature motif; other site
718255000814	Walker B; other site
718255000815	D-loop; other site
718255000816	H-loop/switch region; other site
718255000817	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
718255000818	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718255000819	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
718255000820	TM-ABC transporter signature motif; other site
718255000821	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718255000822	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718255000823	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
718255000824	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
718255000825	N- and C-terminal domain interface [polypeptide binding]; other site
718255000826	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
718255000827	active site
718255000828	putative catalytic site [active]
718255000829	metal binding site [ion binding]; metal-binding site
718255000830	ATP binding site [chemical binding]; other site
718255000831	carbohydrate binding site [chemical binding]; other site
718255000832	L-rhamnose isomerase; Provisional; Region: PRK01076
718255000833	rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634
718255000834	intersubunit interface [polypeptide binding]; other site
718255000835	active site
718255000836	Zn2+ binding site [ion binding]; other site
718255000837	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
718255000838	MarR family; Region: MarR_2; pfam12802
718255000839	Predicted membrane protein [Function unknown]; Region: COG2364
718255000840	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
718255000841	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
718255000842	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
718255000843	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
718255000844	active site
718255000845	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
718255000846	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
718255000847	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
718255000848	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255000849	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
718255000850	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718255000851	GtrA-like protein; Region: GtrA; pfam04138
718255000852	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255000853	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255000854	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255000855	Walker A/P-loop; other site
718255000856	ATP binding site [chemical binding]; other site
718255000857	Q-loop/lid; other site
718255000858	ABC transporter signature motif; other site
718255000859	Walker B; other site
718255000860	D-loop; other site
718255000861	H-loop/switch region; other site
718255000862	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255000863	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255000864	Flavin Reductases; Region: FlaRed; cl00801
718255000865	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
718255000866	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
718255000867	homodimer interface [polypeptide binding]; other site
718255000868	substrate-cofactor binding pocket; other site
718255000869	catalytic residue [active]
718255000870	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
718255000871	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
718255000872	active site
718255000873	Zn binding site [ion binding]; other site
718255000874	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
718255000875	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
718255000876	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
718255000877	DHH family; Region: DHH; pfam01368
718255000878	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
718255000879	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718255000880	active site
718255000881	HIGH motif; other site
718255000882	nucleotide binding site [chemical binding]; other site
718255000883	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
718255000884	active site
718255000885	KMSKS motif; other site
718255000886	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
718255000887	tRNA binding surface [nucleotide binding]; other site
718255000888	anticodon binding site; other site
718255000889	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
718255000890	homodimer interface [polypeptide binding]; other site
718255000891	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
718255000892	active site pocket [active]
718255000893	Predicted membrane protein [Function unknown]; Region: COG4818
718255000894	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255000895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255000896	active site
718255000897	phosphorylation site [posttranslational modification]
718255000898	intermolecular recognition site; other site
718255000899	dimerization interface [polypeptide binding]; other site
718255000900	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255000901	DNA binding site [nucleotide binding]
718255000902	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
718255000903	RNA binding site [nucleotide binding]; other site
718255000904	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
718255000905	RNA binding site [nucleotide binding]; other site
718255000906	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
718255000907	RNA binding site [nucleotide binding]; other site
718255000908	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
718255000909	MarR family; Region: MarR; pfam01047
718255000910	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
718255000911	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
718255000912	N-acetyl-D-glucosamine binding site [chemical binding]; other site
718255000913	catalytic residue [active]
718255000914	AzlC protein; Region: AzlC; cl00570
718255000915	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
718255000916	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
718255000917	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
718255000918	active site
718255000919	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718255000920	substrate binding site [chemical binding]; other site
718255000921	catalytic residues [active]
718255000922	dimer interface [polypeptide binding]; other site
718255000923	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
718255000924	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
718255000925	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
718255000926	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
718255000927	putative dimer interface [polypeptide binding]; other site
718255000928	putative anticodon binding site; other site
718255000929	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
718255000930	homodimer interface [polypeptide binding]; other site
718255000931	motif 1; other site
718255000932	motif 2; other site
718255000933	active site
718255000934	motif 3; other site
718255000935	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
718255000936	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
718255000937	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
718255000938	active site
718255000939	catalytic residues [active]
718255000940	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
718255000941	xanthine permease; Region: pbuX; TIGR03173
718255000942	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
718255000943	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
718255000944	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
718255000945	Protein export membrane protein; Region: SecD_SecF; pfam02355
718255000946	Predicted membrane protein [Function unknown]; Region: COG3326
718255000947	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
718255000948	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
718255000949	dimer interface [polypeptide binding]; other site
718255000950	active site
718255000951	glycine-pyridoxal phosphate binding site [chemical binding]; other site
718255000952	folate binding site [chemical binding]; other site
718255000953	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
718255000954	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
718255000955	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
718255000956	6-phosphofructokinase; Provisional; Region: PRK14072
718255000957	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
718255000958	active site
718255000959	ADP/pyrophosphate binding site [chemical binding]; other site
718255000960	dimerization interface [polypeptide binding]; other site
718255000961	allosteric effector site; other site
718255000962	fructose-1,6-bisphosphate binding site; other site
718255000963	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
718255000964	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
718255000965	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
718255000966	Clp amino terminal domain; Region: Clp_N; pfam02861
718255000967	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255000968	Walker A motif; other site
718255000969	ATP binding site [chemical binding]; other site
718255000970	Walker B motif; other site
718255000971	arginine finger; other site
718255000972	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255000973	Walker A motif; other site
718255000974	ATP binding site [chemical binding]; other site
718255000975	Walker B motif; other site
718255000976	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
718255000977	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255000978	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255000979	catalytic residues [active]
718255000980	catalytic nucleophile [active]
718255000981	Recombinase; Region: Recombinase; pfam07508
718255000982	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255000983	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255000984	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255000985	catalytic residues [active]
718255000986	catalytic nucleophile [active]
718255000987	Recombinase; Region: Recombinase; pfam07508
718255000988	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255000989	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255000990	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255000991	catalytic residues [active]
718255000992	catalytic nucleophile [active]
718255000993	Recombinase; Region: Recombinase; pfam07508
718255000994	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255000995	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
718255000996	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718255000997	ATP binding site [chemical binding]; other site
718255000998	putative Mg++ binding site [ion binding]; other site
718255000999	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718255001000	nucleotide binding region [chemical binding]; other site
718255001001	ATP-binding site [chemical binding]; other site
718255001002	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
718255001003	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
718255001004	active site
718255001005	8-oxo-dGMP binding site [chemical binding]; other site
718255001006	nudix motif; other site
718255001007	metal binding site [ion binding]; metal-binding site
718255001008	HNH endonuclease; Region: HNH_4; pfam13395
718255001009	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
718255001010	FMN binding site [chemical binding]; other site
718255001011	dimer interface [polypeptide binding]; other site
718255001012	Transglutaminase/protease-like homologues; Region: TGc; smart00460
718255001013	Predicted transcriptional regulator [Transcription]; Region: COG2378
718255001014	WYL domain; Region: WYL; pfam13280
718255001015	RelB antitoxin; Region: RelB; cl01171
718255001016	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
718255001017	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
718255001018	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
718255001019	Beta-lactamase; Region: Beta-lactamase; pfam00144
718255001020	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
718255001021	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
718255001022	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255001023	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
718255001024	catalytic residues [active]
718255001025	catalytic nucleophile [active]
718255001026	Presynaptic Site I dimer interface [polypeptide binding]; other site
718255001027	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
718255001028	Synaptic Flat tetramer interface [polypeptide binding]; other site
718255001029	Synaptic Site I dimer interface [polypeptide binding]; other site
718255001030	DNA binding site [nucleotide binding]
718255001031	Recombinase; Region: Recombinase; pfam07508
718255001032	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255001033	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
718255001034	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
718255001035	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
718255001036	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
718255001037	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
718255001038	Part of AAA domain; Region: AAA_19; pfam13245
718255001039	Family description; Region: UvrD_C_2; pfam13538
718255001040	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
718255001041	Maf-like protein; Region: Maf; pfam02545
718255001042	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
718255001043	active site
718255001044	dimer interface [polypeptide binding]; other site
718255001045	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
718255001046	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
718255001047	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
718255001048	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255001049	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718255001050	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
718255001051	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718255001052	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718255001053	ABC transporter; Region: ABC_tran_2; pfam12848
718255001054	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718255001055	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
718255001056	Cupin domain; Region: Cupin_2; cl17218
718255001057	EDD domain protein, DegV family; Region: DegV; TIGR00762
718255001058	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
718255001059	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
718255001060	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718255001061	Walker A motif; other site
718255001062	ATP binding site [chemical binding]; other site
718255001063	Walker B motif; other site
718255001064	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255001065	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
718255001066	Int/Topo IB signature motif; other site
718255001067	Helix-turn-helix domain; Region: HTH_17; cl17695
718255001068	MobA/MobL family; Region: MobA_MobL; pfam03389
718255001069	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255001070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255001071	active site
718255001072	phosphorylation site [posttranslational modification]
718255001073	intermolecular recognition site; other site
718255001074	dimerization interface [polypeptide binding]; other site
718255001075	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255001076	DNA binding site [nucleotide binding]
718255001077	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255001078	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255001079	ATP binding site [chemical binding]; other site
718255001080	Mg2+ binding site [ion binding]; other site
718255001081	G-X-G motif; other site
718255001082	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718255001083	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718255001084	Walker A/P-loop; other site
718255001085	ATP binding site [chemical binding]; other site
718255001086	Q-loop/lid; other site
718255001087	ABC transporter signature motif; other site
718255001088	Walker B; other site
718255001089	D-loop; other site
718255001090	H-loop/switch region; other site
718255001091	FtsX-like permease family; Region: FtsX; pfam02687
718255001092	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718255001093	nucleotide binding site [chemical binding]; other site
718255001094	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
718255001095	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718255001096	nucleotide binding site [chemical binding]; other site
718255001097	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
718255001098	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
718255001099	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
718255001100	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
718255001101	Rhomboid family; Region: Rhomboid; cl11446
718255001102	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
718255001103	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
718255001104	putative NADH binding site [chemical binding]; other site
718255001105	putative active site [active]
718255001106	nudix motif; other site
718255001107	putative metal binding site [ion binding]; other site
718255001108	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
718255001109	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718255001110	HlyD family secretion protein; Region: HlyD_3; pfam13437
718255001111	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718255001112	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718255001113	Walker A/P-loop; other site
718255001114	ATP binding site [chemical binding]; other site
718255001115	Q-loop/lid; other site
718255001116	ABC transporter signature motif; other site
718255001117	Walker B; other site
718255001118	D-loop; other site
718255001119	H-loop/switch region; other site
718255001120	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718255001121	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
718255001122	FtsX-like permease family; Region: FtsX; pfam02687
718255001123	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
718255001124	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
718255001125	NodB motif; other site
718255001126	active site
718255001127	catalytic site [active]
718255001128	Cd binding site [ion binding]; other site
718255001129	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
718255001130	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
718255001131	active site
718255001132	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
718255001133	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
718255001134	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
718255001135	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
718255001136	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
718255001137	Tetramer interface [polypeptide binding]; other site
718255001138	active site
718255001139	FMN-binding site [chemical binding]; other site
718255001140	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
718255001141	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
718255001142	hinge; other site
718255001143	active site
718255001144	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
718255001145	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
718255001146	Preprotein translocase subunit; Region: YajC; pfam02699
718255001147	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255001148	non-specific DNA binding site [nucleotide binding]; other site
718255001149	salt bridge; other site
718255001150	sequence-specific DNA binding site [nucleotide binding]; other site
718255001151	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
718255001152	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255001153	FeS/SAM binding site; other site
718255001154	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
718255001155	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255001156	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255001157	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255001158	Walker A/P-loop; other site
718255001159	ATP binding site [chemical binding]; other site
718255001160	Q-loop/lid; other site
718255001161	ABC transporter signature motif; other site
718255001162	Walker B; other site
718255001163	D-loop; other site
718255001164	H-loop/switch region; other site
718255001165	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
718255001166	tartrate dehydrogenase; Region: TTC; TIGR02089
718255001167	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
718255001168	6-phosphogluconate dehydratase; Region: edd; TIGR01196
718255001169	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
718255001170	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
718255001171	PYR/PP interface [polypeptide binding]; other site
718255001172	dimer interface [polypeptide binding]; other site
718255001173	TPP binding site [chemical binding]; other site
718255001174	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
718255001175	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
718255001176	TPP-binding site [chemical binding]; other site
718255001177	dimer interface [polypeptide binding]; other site
718255001178	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
718255001179	homodimer interface [polypeptide binding]; other site
718255001180	substrate-cofactor binding pocket; other site
718255001181	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255001182	catalytic residue [active]
718255001183	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
718255001184	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
718255001185	putative ligand binding site [chemical binding]; other site
718255001186	putative NAD binding site [chemical binding]; other site
718255001187	putative catalytic site [active]
718255001188	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
718255001189	L-serine binding site [chemical binding]; other site
718255001190	ACT domain interface; other site
718255001191	Uncharacterized conserved protein [Function unknown]; Region: COG4198
718255001192	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
718255001193	mechanosensitive channel MscS; Provisional; Region: PRK10334
718255001194	Mechanosensitive ion channel; Region: MS_channel; pfam00924
718255001195	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
718255001196	DNA-binding site [nucleotide binding]; DNA binding site
718255001197	RNA-binding motif; other site
718255001198	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
718255001199	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
718255001200	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
718255001201	Peptidase M16C associated; Region: M16C_assoc; pfam08367
718255001202	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
718255001203	GTPase Era; Reviewed; Region: era; PRK00089
718255001204	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
718255001205	G1 box; other site
718255001206	GTP/Mg2+ binding site [chemical binding]; other site
718255001207	Switch I region; other site
718255001208	G2 box; other site
718255001209	Switch II region; other site
718255001210	G3 box; other site
718255001211	G4 box; other site
718255001212	G5 box; other site
718255001213	KH domain; Region: KH_2; pfam07650
718255001214	glycyl-tRNA synthetase; Provisional; Region: PRK04173
718255001215	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
718255001216	motif 1; other site
718255001217	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
718255001218	active site
718255001219	motif 2; other site
718255001220	motif 3; other site
718255001221	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
718255001222	anticodon binding site; other site
718255001223	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
718255001224	Acyltransferase family; Region: Acyl_transf_3; pfam01757
718255001225	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
718255001226	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
718255001227	HTH domain; Region: HTH_11; cl17392
718255001228	GrpE; Region: GrpE; pfam01025
718255001229	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
718255001230	dimer interface [polypeptide binding]; other site
718255001231	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
718255001232	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
718255001233	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
718255001234	nucleotide binding site [chemical binding]; other site
718255001235	NEF interaction site [polypeptide binding]; other site
718255001236	SBD interface [polypeptide binding]; other site
718255001237	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
718255001238	chaperone protein DnaJ; Provisional; Region: PRK10767
718255001239	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
718255001240	HSP70 interaction site [polypeptide binding]; other site
718255001241	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
718255001242	substrate binding site [polypeptide binding]; other site
718255001243	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
718255001244	Zn binding sites [ion binding]; other site
718255001245	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
718255001246	dimer interface [polypeptide binding]; other site
718255001247	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
718255001248	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
718255001249	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
718255001250	metal binding site 2 [ion binding]; metal-binding site
718255001251	putative DNA binding helix; other site
718255001252	metal binding site 1 [ion binding]; metal-binding site
718255001253	dimer interface [polypeptide binding]; other site
718255001254	structural Zn2+ binding site [ion binding]; other site
718255001255	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
718255001256	Peptidase family M23; Region: Peptidase_M23; pfam01551
718255001257	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718255001258	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255001259	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255001260	metal binding site [ion binding]; metal-binding site
718255001261	active site
718255001262	I-site; other site
718255001263	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
718255001264	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
718255001265	G1 box; other site
718255001266	putative GEF interaction site [polypeptide binding]; other site
718255001267	GTP/Mg2+ binding site [chemical binding]; other site
718255001268	Switch I region; other site
718255001269	G2 box; other site
718255001270	G3 box; other site
718255001271	Switch II region; other site
718255001272	G4 box; other site
718255001273	G5 box; other site
718255001274	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
718255001275	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
718255001276	single-stranded DNA-binding protein; Provisional; Region: PRK05813
718255001277	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
718255001278	dimer interface [polypeptide binding]; other site
718255001279	ssDNA binding site [nucleotide binding]; other site
718255001280	tetramer (dimer of dimers) interface [polypeptide binding]; other site
718255001281	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
718255001282	dihydrodipicolinate synthase; Region: dapA; TIGR00674
718255001283	dimer interface [polypeptide binding]; other site
718255001284	active site
718255001285	catalytic residue [active]
718255001286	dihydrodipicolinate reductase; Provisional; Region: PRK00048
718255001287	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
718255001288	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
718255001289	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
718255001290	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
718255001291	endonuclease IV; Provisional; Region: PRK01060
718255001292	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
718255001293	AP (apurinic/apyrimidinic) site pocket; other site
718255001294	DNA interaction; other site
718255001295	Metal-binding active site; metal-binding site
718255001296	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
718255001297	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
718255001298	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718255001299	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
718255001300	spermidine synthase; Provisional; Region: PRK00811
718255001301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255001302	S-adenosylmethionine binding site [chemical binding]; other site
718255001303	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
718255001304	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
718255001305	agmatine deiminase; Region: agmatine_aguA; TIGR03380
718255001306	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
718255001307	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
718255001308	putative active site; other site
718255001309	catalytic triad [active]
718255001310	putative dimer interface [polypeptide binding]; other site
718255001311	asparagine synthetase AsnA; Provisional; Region: PRK05425
718255001312	motif 1; other site
718255001313	dimer interface [polypeptide binding]; other site
718255001314	active site
718255001315	motif 2; other site
718255001316	motif 3; other site
718255001317	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
718255001318	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255001319	dimerization interface [polypeptide binding]; other site
718255001320	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255001321	dimer interface [polypeptide binding]; other site
718255001322	putative CheW interface [polypeptide binding]; other site
718255001323	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
718255001324	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718255001325	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
718255001326	putative active site [active]
718255001327	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255001328	sequence-specific DNA binding site [nucleotide binding]; other site
718255001329	salt bridge; other site
718255001330	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
718255001331	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
718255001332	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
718255001333	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
718255001334	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
718255001335	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
718255001336	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
718255001337	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
718255001338	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
718255001339	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
718255001340	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
718255001341	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
718255001342	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718255001343	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718255001344	Walker A/P-loop; other site
718255001345	ATP binding site [chemical binding]; other site
718255001346	Q-loop/lid; other site
718255001347	ABC transporter signature motif; other site
718255001348	Walker B; other site
718255001349	D-loop; other site
718255001350	H-loop/switch region; other site
718255001351	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718255001352	FtsX-like permease family; Region: FtsX; pfam02687
718255001353	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255001354	Walker A/P-loop; other site
718255001355	ATP binding site [chemical binding]; other site
718255001356	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
718255001357	Walker A/P-loop; other site
718255001358	ATP binding site [chemical binding]; other site
718255001359	Q-loop/lid; other site
718255001360	ABC transporter signature motif; other site
718255001361	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255001362	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
718255001363	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
718255001364	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
718255001365	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
718255001366	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255001367	Walker A/P-loop; other site
718255001368	ATP binding site [chemical binding]; other site
718255001369	Q-loop/lid; other site
718255001370	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718255001371	ABC transporter signature motif; other site
718255001372	Walker B; other site
718255001373	ABC transporter; Region: ABC_tran_2; pfam12848
718255001374	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718255001375	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
718255001376	Predicted transcriptional regulators [Transcription]; Region: COG1725
718255001377	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718255001378	DNA-binding site [nucleotide binding]; DNA binding site
718255001379	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
718255001380	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
718255001381	Walker A/P-loop; other site
718255001382	ATP binding site [chemical binding]; other site
718255001383	Q-loop/lid; other site
718255001384	ABC transporter signature motif; other site
718255001385	Walker B; other site
718255001386	D-loop; other site
718255001387	H-loop/switch region; other site
718255001388	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
718255001389	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255001390	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255001391	metal binding site [ion binding]; metal-binding site
718255001392	active site
718255001393	I-site; other site
718255001394	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718255001395	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
718255001396	putative substrate translocation pore; other site
718255001397	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
718255001398	Na2 binding site [ion binding]; other site
718255001399	putative substrate binding site 1 [chemical binding]; other site
718255001400	Na binding site 1 [ion binding]; other site
718255001401	putative substrate binding site 2 [chemical binding]; other site
718255001402	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
718255001403	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718255001404	ATP binding site [chemical binding]; other site
718255001405	putative Mg++ binding site [ion binding]; other site
718255001406	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718255001407	nucleotide binding region [chemical binding]; other site
718255001408	ATP-binding site [chemical binding]; other site
718255001409	HRDC domain; Region: HRDC; pfam00570
718255001410	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255001411	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
718255001412	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255001413	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255001414	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718255001415	dimerization interface [polypeptide binding]; other site
718255001416	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
718255001417	catalytic triad [active]
718255001418	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
718255001419	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255001420	motif II; other site
718255001421	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
718255001422	Part of AAA domain; Region: AAA_19; pfam13245
718255001423	Family description; Region: UvrD_C_2; pfam13538
718255001424	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
718255001425	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
718255001426	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255001427	DNA binding site [nucleotide binding]
718255001428	active site
718255001429	Int/Topo IB signature motif; other site
718255001430	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
718255001431	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
718255001432	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255001433	non-specific DNA binding site [nucleotide binding]; other site
718255001434	salt bridge; other site
718255001435	sequence-specific DNA binding site [nucleotide binding]; other site
718255001436	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255001437	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
718255001438	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
718255001439	transcription termination factor Rho; Provisional; Region: PRK12608
718255001440	RNA binding site [nucleotide binding]; other site
718255001441	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718255001442	Walker A motif; other site
718255001443	ATP binding site [chemical binding]; other site
718255001444	Walker B motif; other site
718255001445	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
718255001446	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
718255001447	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
718255001448	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255001449	S-adenosylmethionine binding site [chemical binding]; other site
718255001450	peptide chain release factor 1; Validated; Region: prfA; PRK00591
718255001451	This domain is found in peptide chain release factors; Region: PCRF; smart00937
718255001452	RF-1 domain; Region: RF-1; pfam00472
718255001453	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
718255001454	AAA domain; Region: AAA_14; pfam13173
718255001455	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
718255001456	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718255001457	active site
718255001458	HIGH motif; other site
718255001459	nucleotide binding site [chemical binding]; other site
718255001460	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718255001461	active site
718255001462	KMSKS motif; other site
718255001463	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
718255001464	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
718255001465	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
718255001466	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
718255001467	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718255001468	DNA-binding site [nucleotide binding]; DNA binding site
718255001469	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718255001470	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255001471	homodimer interface [polypeptide binding]; other site
718255001472	catalytic residue [active]
718255001473	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
718255001474	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
718255001475	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
718255001476	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
718255001477	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718255001478	Walker A/P-loop; other site
718255001479	ATP binding site [chemical binding]; other site
718255001480	Q-loop/lid; other site
718255001481	ABC transporter signature motif; other site
718255001482	Walker B; other site
718255001483	D-loop; other site
718255001484	H-loop/switch region; other site
718255001485	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718255001486	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
718255001487	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718255001488	Walker A/P-loop; other site
718255001489	ATP binding site [chemical binding]; other site
718255001490	Q-loop/lid; other site
718255001491	ABC transporter signature motif; other site
718255001492	Walker B; other site
718255001493	D-loop; other site
718255001494	H-loop/switch region; other site
718255001495	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
718255001496	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
718255001497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255001498	dimer interface [polypeptide binding]; other site
718255001499	conserved gate region; other site
718255001500	putative PBP binding loops; other site
718255001501	ABC-ATPase subunit interface; other site
718255001502	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
718255001503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255001504	dimer interface [polypeptide binding]; other site
718255001505	conserved gate region; other site
718255001506	putative PBP binding loops; other site
718255001507	ABC-ATPase subunit interface; other site
718255001508	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
718255001509	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
718255001510	metal binding site [ion binding]; metal-binding site
718255001511	argininosuccinate synthase; Provisional; Region: PRK13820
718255001512	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
718255001513	ANP binding site [chemical binding]; other site
718255001514	Substrate Binding Site II [chemical binding]; other site
718255001515	Substrate Binding Site I [chemical binding]; other site
718255001516	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
718255001517	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
718255001518	putative acetyltransferase; Provisional; Region: PRK03624
718255001519	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255001520	Coenzyme A binding pocket [chemical binding]; other site
718255001521	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
718255001522	heterotetramer interface [polypeptide binding]; other site
718255001523	active site pocket [active]
718255001524	cleavage site
718255001525	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
718255001526	feedback inhibition sensing region; other site
718255001527	homohexameric interface [polypeptide binding]; other site
718255001528	nucleotide binding site [chemical binding]; other site
718255001529	N-acetyl-L-glutamate binding site [chemical binding]; other site
718255001530	acetylornithine aminotransferase; Provisional; Region: PRK02627
718255001531	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
718255001532	inhibitor-cofactor binding pocket; inhibition site
718255001533	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255001534	catalytic residue [active]
718255001535	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
718255001536	SLBB domain; Region: SLBB; pfam10531
718255001537	comEA protein; Region: comE; TIGR01259
718255001538	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255001539	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255001540	active site
718255001541	phosphorylation site [posttranslational modification]
718255001542	intermolecular recognition site; other site
718255001543	dimerization interface [polypeptide binding]; other site
718255001544	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255001545	DNA binding site [nucleotide binding]
718255001546	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
718255001547	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255001548	dimer interface [polypeptide binding]; other site
718255001549	phosphorylation site [posttranslational modification]
718255001550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255001551	ATP binding site [chemical binding]; other site
718255001552	Mg2+ binding site [ion binding]; other site
718255001553	G-X-G motif; other site
718255001554	Sporulation and spore germination; Region: Germane; pfam10646
718255001555	Sporulation and spore germination; Region: Germane; pfam10646
718255001556	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
718255001557	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
718255001558	Competence protein; Region: Competence; pfam03772
718255001559	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
718255001560	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
718255001561	germination protease; Provisional; Region: PRK12362
718255001562	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
718255001563	stage II sporulation protein P; Region: spore_II_P; TIGR02867
718255001564	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
718255001565	active site
718255001566	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
718255001567	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
718255001568	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
718255001569	active site
718255001570	dimer interface [polypeptide binding]; other site
718255001571	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
718255001572	Ligand Binding Site [chemical binding]; other site
718255001573	Molecular Tunnel; other site
718255001574	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
718255001575	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
718255001576	active site
718255001577	catalytic triad [active]
718255001578	AAA domain; Region: AAA_31; pfam13614
718255001579	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718255001580	P-loop; other site
718255001581	Magnesium ion binding site [ion binding]; other site
718255001582	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718255001583	Magnesium ion binding site [ion binding]; other site
718255001584	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255001585	sequence-specific DNA binding site [nucleotide binding]; other site
718255001586	salt bridge; other site
718255001587	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
718255001588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255001589	active site
718255001590	phosphorylation site [posttranslational modification]
718255001591	intermolecular recognition site; other site
718255001592	dimerization interface [polypeptide binding]; other site
718255001593	LytTr DNA-binding domain; Region: LytTR; pfam04397
718255001594	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255001595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255001596	ATP binding site [chemical binding]; other site
718255001597	Mg2+ binding site [ion binding]; other site
718255001598	G-X-G motif; other site
718255001599	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
718255001600	Accessory gene regulator B; Region: AgrB; pfam04647
718255001601	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
718255001602	metal ion-dependent adhesion site (MIDAS); other site
718255001603	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
718255001604	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
718255001605	HSP70 interaction site [polypeptide binding]; other site
718255001606	active site
718255001607	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
718255001608	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
718255001609	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
718255001610	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
718255001611	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
718255001612	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
718255001613	Transposase IS200 like; Region: Y1_Tnp; cl00848
718255001614	Transposase IS200 like; Region: Y1_Tnp; cl00848
718255001615	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
718255001616	Sugar fermentation stimulation protein; Region: SfsA; cl00647
718255001617	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
718255001618	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255001619	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255001620	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718255001621	YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094
718255001622	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255001623	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
718255001624	Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_4; cd11751
718255001625	Protein of unknown function, DUF608; Region: DUF608; pfam04685
718255001626	MFS/sugar transport protein; Region: MFS_2; pfam13347
718255001627	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
718255001628	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
718255001629	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
718255001630	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
718255001631	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255001632	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255001633	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
718255001634	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255001635	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255001636	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718255001637	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
718255001638	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
718255001639	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255001640	salt bridge; other site
718255001641	non-specific DNA binding site [nucleotide binding]; other site
718255001642	sequence-specific DNA binding site [nucleotide binding]; other site
718255001643	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
718255001644	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255001645	active site
718255001646	phosphorylation site [posttranslational modification]
718255001647	intermolecular recognition site; other site
718255001648	dimerization interface [polypeptide binding]; other site
718255001649	LytTr DNA-binding domain; Region: LytTR; pfam04397
718255001650	TIR domain; Region: TIR_2; pfam13676
718255001651	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
718255001652	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
718255001653	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255001654	catalytic residues [active]
718255001655	catalytic nucleophile [active]
718255001656	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255001657	Recombinase; Region: Recombinase; pfam07508
718255001658	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255001659	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255001660	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255001661	catalytic residues [active]
718255001662	catalytic nucleophile [active]
718255001663	Recombinase; Region: Recombinase; pfam07508
718255001664	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255001665	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255001666	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255001667	catalytic residues [active]
718255001668	catalytic nucleophile [active]
718255001669	Recombinase; Region: Recombinase; pfam07508
718255001670	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255001671	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
718255001672	nudix motif; other site
718255001673	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255001674	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
718255001675	FeoA domain; Region: FeoA; pfam04023
718255001676	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
718255001677	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
718255001678	G1 box; other site
718255001679	GTP/Mg2+ binding site [chemical binding]; other site
718255001680	Switch I region; other site
718255001681	G2 box; other site
718255001682	G3 box; other site
718255001683	Switch II region; other site
718255001684	G4 box; other site
718255001685	G5 box; other site
718255001686	Nucleoside recognition; Region: Gate; pfam07670
718255001687	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
718255001688	Nucleoside recognition; Region: Gate; pfam07670
718255001689	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
718255001690	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
718255001691	chaperone protein DnaJ; Provisional; Region: PRK14277
718255001692	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
718255001693	HSP70 interaction site [polypeptide binding]; other site
718255001694	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
718255001695	substrate binding site [polypeptide binding]; other site
718255001696	dimer interface [polypeptide binding]; other site
718255001697	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
718255001698	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
718255001699	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
718255001700	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718255001701	catalytic residue [active]
718255001702	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
718255001703	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255001704	motif II; other site
718255001705	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
718255001706	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255001707	Walker A/P-loop; other site
718255001708	ATP binding site [chemical binding]; other site
718255001709	Q-loop/lid; other site
718255001710	ABC transporter signature motif; other site
718255001711	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718255001712	ABC transporter; Region: ABC_tran_2; pfam12848
718255001713	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718255001714	PAS fold; Region: PAS_3; pfam08447
718255001715	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255001716	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255001717	metal binding site [ion binding]; metal-binding site
718255001718	active site
718255001719	I-site; other site
718255001720	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255001721	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255001722	metal binding site [ion binding]; metal-binding site
718255001723	active site
718255001724	I-site; other site
718255001725	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718255001726	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
718255001727	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
718255001728	dimer interface [polypeptide binding]; other site
718255001729	PYR/PP interface [polypeptide binding]; other site
718255001730	TPP binding site [chemical binding]; other site
718255001731	substrate binding site [chemical binding]; other site
718255001732	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
718255001733	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
718255001734	Domain of unknown function; Region: EKR; pfam10371
718255001735	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718255001736	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
718255001737	TPP-binding site [chemical binding]; other site
718255001738	dimer interface [polypeptide binding]; other site
718255001739	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
718255001740	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
718255001741	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718255001742	dimerization domain swap beta strand [polypeptide binding]; other site
718255001743	regulatory protein interface [polypeptide binding]; other site
718255001744	active site
718255001745	regulatory phosphorylation site [posttranslational modification]; other site
718255001746	transcriptional antiterminator BglG; Provisional; Region: PRK09772
718255001747	CAT RNA binding domain; Region: CAT_RBD; smart01061
718255001748	PRD domain; Region: PRD; pfam00874
718255001749	PRD domain; Region: PRD; pfam00874
718255001750	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
718255001751	PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826
718255001752	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
718255001753	active site turn [active]
718255001754	phosphorylation site [posttranslational modification]
718255001755	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
718255001756	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
718255001757	DRTGG domain; Region: DRTGG; pfam07085
718255001758	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
718255001759	DHH family; Region: DHH; pfam01368
718255001760	DHHA2 domain; Region: DHHA2; pfam02833
718255001761	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718255001762	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255001763	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255001764	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255001765	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
718255001766	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
718255001767	homodimer interface [polypeptide binding]; other site
718255001768	substrate-cofactor binding pocket; other site
718255001769	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255001770	catalytic residue [active]
718255001771	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
718255001772	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
718255001773	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
718255001774	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
718255001775	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
718255001776	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
718255001777	putative active site [active]
718255001778	putative catalytic site [active]
718255001779	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
718255001780	HemN C-terminal domain; Region: HemN_C; pfam06969
718255001781	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
718255001782	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
718255001783	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
718255001784	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
718255001785	4Fe-4S binding domain; Region: Fer4; pfam00037
718255001786	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
718255001787	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718255001788	4Fe-4S binding domain; Region: Fer4; pfam00037
718255001789	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
718255001790	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
718255001791	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
718255001792	[FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956
718255001793	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255001794	FeS/SAM binding site; other site
718255001795	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
718255001796	[FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955
718255001797	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255001798	FeS/SAM binding site; other site
718255001799	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
718255001800	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
718255001801	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
718255001802	G1 box; other site
718255001803	GTP/Mg2+ binding site [chemical binding]; other site
718255001804	Switch I region; other site
718255001805	G2 box; other site
718255001806	Switch II region; other site
718255001807	G3 box; other site
718255001808	G4 box; other site
718255001809	G5 box; other site
718255001810	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
718255001811	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
718255001812	dimer interface [polypeptide binding]; other site
718255001813	active site
718255001814	metal binding site [ion binding]; metal-binding site
718255001815	heat shock protein 90; Provisional; Region: PRK05218
718255001816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255001817	ATP binding site [chemical binding]; other site
718255001818	Mg2+ binding site [ion binding]; other site
718255001819	G-X-G motif; other site
718255001820	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
718255001821	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
718255001822	NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179
718255001823	putative active site [active]
718255001824	metal binding site [ion binding]; metal-binding site
718255001825	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
718255001826	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
718255001827	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
718255001828	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
718255001829	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
718255001830	pyruvate phosphate dikinase; Provisional; Region: PRK09279
718255001831	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
718255001832	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
718255001833	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
718255001834	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
718255001835	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718255001836	Flavodoxin domain; Region: Flavodoxin_5; cl17428
718255001837	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
718255001838	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
718255001839	Erythromycin esterase; Region: Erythro_esteras; pfam05139
718255001840	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
718255001841	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
718255001842	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
718255001843	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
718255001844	active site
718255001845	metal binding site [ion binding]; metal-binding site
718255001846	DNA binding site [nucleotide binding]
718255001847	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
718255001848	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255001849	AAA domain; Region: AAA_23; pfam13476
718255001850	Walker A/P-loop; other site
718255001851	ATP binding site [chemical binding]; other site
718255001852	Q-loop/lid; other site
718255001853	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
718255001854	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255001855	ABC transporter signature motif; other site
718255001856	Walker B; other site
718255001857	D-loop; other site
718255001858	H-loop/switch region; other site
718255001859	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
718255001860	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
718255001861	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718255001862	catalytic residue [active]
718255001863	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255001864	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255001865	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
718255001866	Walker A/P-loop; other site
718255001867	ATP binding site [chemical binding]; other site
718255001868	Q-loop/lid; other site
718255001869	ABC transporter signature motif; other site
718255001870	Walker B; other site
718255001871	D-loop; other site
718255001872	H-loop/switch region; other site
718255001873	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255001874	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255001875	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255001876	Walker A/P-loop; other site
718255001877	ATP binding site [chemical binding]; other site
718255001878	Q-loop/lid; other site
718255001879	ABC transporter signature motif; other site
718255001880	Walker B; other site
718255001881	D-loop; other site
718255001882	H-loop/switch region; other site
718255001883	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
718255001884	MarR family; Region: MarR_2; pfam12802
718255001885	Predicted permeases [General function prediction only]; Region: COG0730
718255001886	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
718255001887	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
718255001888	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
718255001889	DctM-like transporters; Region: DctM; pfam06808
718255001890	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
718255001891	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
718255001892	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255001893	dimerization interface [polypeptide binding]; other site
718255001894	Histidine kinase; Region: His_kinase; pfam06580
718255001895	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255001896	ATP binding site [chemical binding]; other site
718255001897	Mg2+ binding site [ion binding]; other site
718255001898	G-X-G motif; other site
718255001899	Response regulator receiver domain; Region: Response_reg; pfam00072
718255001900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255001901	active site
718255001902	phosphorylation site [posttranslational modification]
718255001903	intermolecular recognition site; other site
718255001904	dimerization interface [polypeptide binding]; other site
718255001905	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255001906	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255001907	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255001908	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
718255001909	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
718255001910	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
718255001911	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718255001912	putative substrate translocation pore; other site
718255001913	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
718255001914	prolyl-tRNA synthetase; Provisional; Region: PRK09194
718255001915	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
718255001916	motif 1; other site
718255001917	dimer interface [polypeptide binding]; other site
718255001918	active site
718255001919	motif 2; other site
718255001920	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
718255001921	putative deacylase active site [active]
718255001922	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
718255001923	active site
718255001924	motif 3; other site
718255001925	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
718255001926	anticodon binding site; other site
718255001927	Divergent AAA domain; Region: AAA_4; pfam04326
718255001928	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
718255001929	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718255001930	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255001931	homodimer interface [polypeptide binding]; other site
718255001932	catalytic residue [active]
718255001933	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
718255001934	Precorrin-8X methylmutase; Region: CbiC; pfam02570
718255001935	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
718255001936	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
718255001937	active site
718255001938	SAM binding site [chemical binding]; other site
718255001939	homodimer interface [polypeptide binding]; other site
718255001940	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
718255001941	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
718255001942	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
718255001943	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
718255001944	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
718255001945	active site
718255001946	SAM binding site [chemical binding]; other site
718255001947	homodimer interface [polypeptide binding]; other site
718255001948	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
718255001949	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
718255001950	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
718255001951	active site
718255001952	putative homodimer interface [polypeptide binding]; other site
718255001953	SAM binding site [chemical binding]; other site
718255001954	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
718255001955	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255001956	S-adenosylmethionine binding site [chemical binding]; other site
718255001957	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
718255001958	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
718255001959	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
718255001960	catalytic triad [active]
718255001961	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
718255001962	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
718255001963	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
718255001964	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255001965	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255001966	dimer interface [polypeptide binding]; other site
718255001967	phosphorylation site [posttranslational modification]
718255001968	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255001969	ATP binding site [chemical binding]; other site
718255001970	Mg2+ binding site [ion binding]; other site
718255001971	G-X-G motif; other site
718255001972	Response regulator receiver domain; Region: Response_reg; pfam00072
718255001973	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255001974	active site
718255001975	phosphorylation site [posttranslational modification]
718255001976	intermolecular recognition site; other site
718255001977	dimerization interface [polypeptide binding]; other site
718255001978	Coat F domain; Region: Coat_F; pfam07875
718255001979	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
718255001980	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
718255001981	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
718255001982	putative deacylase active site [active]
718255001983	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
718255001984	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
718255001985	active site
718255001986	metal binding site [ion binding]; metal-binding site
718255001987	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255001988	Coenzyme A binding pocket [chemical binding]; other site
718255001989	EDD domain protein, DegV family; Region: DegV; TIGR00762
718255001990	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
718255001991	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255001992	Radical SAM superfamily; Region: Radical_SAM; pfam04055
718255001993	FeS/SAM binding site; other site
718255001994	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255001995	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255001996	active site
718255001997	phosphorylation site [posttranslational modification]
718255001998	intermolecular recognition site; other site
718255001999	dimerization interface [polypeptide binding]; other site
718255002000	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255002001	DNA binding site [nucleotide binding]
718255002002	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
718255002003	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
718255002004	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
718255002005	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255002006	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255002007	dimerization interface [polypeptide binding]; other site
718255002008	Histidine kinase; Region: His_kinase; pfam06580
718255002009	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255002010	ATP binding site [chemical binding]; other site
718255002011	Mg2+ binding site [ion binding]; other site
718255002012	G-X-G motif; other site
718255002013	Response regulator receiver domain; Region: Response_reg; pfam00072
718255002014	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255002015	active site
718255002016	phosphorylation site [posttranslational modification]
718255002017	intermolecular recognition site; other site
718255002018	dimerization interface [polypeptide binding]; other site
718255002019	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718255002020	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255002021	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255002022	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718255002023	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718255002024	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255002025	dimer interface [polypeptide binding]; other site
718255002026	conserved gate region; other site
718255002027	putative PBP binding loops; other site
718255002028	ABC-ATPase subunit interface; other site
718255002029	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255002030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255002031	dimer interface [polypeptide binding]; other site
718255002032	conserved gate region; other site
718255002033	putative PBP binding loops; other site
718255002034	ABC-ATPase subunit interface; other site
718255002035	NifU-like domain; Region: NifU; cl00484
718255002036	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
718255002037	active site
718255002038	catalytic site [active]
718255002039	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
718255002040	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
718255002041	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
718255002042	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718255002043	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718255002044	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718255002045	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
718255002046	FeoA domain; Region: FeoA; pfam04023
718255002047	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
718255002048	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
718255002049	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
718255002050	G1 box; other site
718255002051	GTP/Mg2+ binding site [chemical binding]; other site
718255002052	Switch I region; other site
718255002053	G2 box; other site
718255002054	G3 box; other site
718255002055	Switch II region; other site
718255002056	G4 box; other site
718255002057	G5 box; other site
718255002058	Nucleoside recognition; Region: Gate; pfam07670
718255002059	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
718255002060	Nucleoside recognition; Region: Gate; pfam07670
718255002061	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
718255002062	metal binding site 2 [ion binding]; metal-binding site
718255002063	putative DNA binding helix; other site
718255002064	structural Zn2+ binding site [ion binding]; other site
718255002065	N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755
718255002066	catalytic domain interface [polypeptide binding]; other site
718255002067	putative homodimer interface [polypeptide binding]; other site
718255002068	Protein of unknown function, DUF608; Region: DUF608; pfam04685
718255002069	N-terminal-like domain of Paenibacillus sp. YM-1 Laminaribiose Phosphorylase and similar proteins; Region: GH94N_LBP_like; cd11749
718255002070	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
718255002071	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255002072	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255002073	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
718255002074	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255002075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255002076	dimer interface [polypeptide binding]; other site
718255002077	conserved gate region; other site
718255002078	putative PBP binding loops; other site
718255002079	ABC-ATPase subunit interface; other site
718255002080	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255002081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255002082	dimer interface [polypeptide binding]; other site
718255002083	conserved gate region; other site
718255002084	putative PBP binding loops; other site
718255002085	ABC-ATPase subunit interface; other site
718255002086	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
718255002087	classical (c) SDRs; Region: SDR_c; cd05233
718255002088	NAD(P) binding site [chemical binding]; other site
718255002089	active site
718255002090	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718255002091	metal-binding site [ion binding]
718255002092	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
718255002093	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718255002094	Soluble P-type ATPase [General function prediction only]; Region: COG4087
718255002095	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
718255002096	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718255002097	Soluble P-type ATPase [General function prediction only]; Region: COG4087
718255002098	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255002099	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255002100	metal binding site [ion binding]; metal-binding site
718255002101	active site
718255002102	I-site; other site
718255002103	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
718255002104	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
718255002105	4Fe-4S binding domain; Region: Fer4; pfam00037
718255002106	4Fe-4S binding domain; Region: Fer4; pfam00037
718255002107	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
718255002108	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255002109	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
718255002110	active site
718255002111	motif I; other site
718255002112	motif II; other site
718255002113	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255002114	motif II; other site
718255002115	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
718255002116	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
718255002117	oligomerisation interface [polypeptide binding]; other site
718255002118	mobile loop; other site
718255002119	roof hairpin; other site
718255002120	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
718255002121	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
718255002122	ring oligomerisation interface [polypeptide binding]; other site
718255002123	ATP/Mg binding site [chemical binding]; other site
718255002124	stacking interactions; other site
718255002125	hinge regions; other site
718255002126	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
718255002127	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718255002128	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255002129	homodimer interface [polypeptide binding]; other site
718255002130	catalytic residue [active]
718255002131	Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546
718255002132	dinuclear metal binding motif [ion binding]; other site
718255002133	CotJB protein; Region: CotJB; pfam12652
718255002134	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
718255002135	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718255002136	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
718255002137	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
718255002138	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
718255002139	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
718255002140	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255002141	dimer interface [polypeptide binding]; other site
718255002142	putative CheW interface [polypeptide binding]; other site
718255002143	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
718255002144	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
718255002145	active site
718255002146	HIGH motif; other site
718255002147	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
718255002148	active site
718255002149	KMSKS motif; other site
718255002150	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
718255002151	Part of AAA domain; Region: AAA_19; pfam13245
718255002152	AAA domain; Region: AAA_14; pfam13173
718255002153	Family description; Region: UvrD_C_2; pfam13538
718255002154	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
718255002155	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
718255002156	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
718255002157	active site
718255002158	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
718255002159	transcriptional repressor CodY; Validated; Region: PRK04158
718255002160	CodY GAF-like domain; Region: CodY; pfam06018
718255002161	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
718255002162	flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396
718255002163	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
718255002164	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
718255002165	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
718255002166	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
718255002167	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
718255002168	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
718255002169	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
718255002170	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
718255002171	MgtE intracellular N domain; Region: MgtE_N; cl15244
718255002172	FliG C-terminal domain; Region: FliG_C; pfam01706
718255002173	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
718255002174	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
718255002175	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
718255002176	Walker A motif/ATP binding site; other site
718255002177	Walker B motif; other site
718255002178	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
718255002179	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
718255002180	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
718255002181	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
718255002182	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
718255002183	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
718255002184	Flagellar protein (FlbD); Region: FlbD; pfam06289
718255002185	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
718255002186	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
718255002187	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
718255002188	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
718255002189	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
718255002190	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
718255002191	CheC-like family; Region: CheC; pfam04509
718255002192	CheC-like family; Region: CheC; pfam04509
718255002193	flagellar motor switch protein FliN; Region: fliN; TIGR02480
718255002194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255002195	Response regulator receiver domain; Region: Response_reg; pfam00072
718255002196	active site
718255002197	phosphorylation site [posttranslational modification]
718255002198	intermolecular recognition site; other site
718255002199	dimerization interface [polypeptide binding]; other site
718255002200	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
718255002201	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
718255002202	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
718255002203	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
718255002204	FHIPEP family; Region: FHIPEP; pfam00771
718255002205	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
718255002206	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
718255002207	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
718255002208	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
718255002209	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
718255002210	P-loop; other site
718255002211	Flagellar protein YcgR; Region: YcgR_2; pfam12945
718255002212	PilZ domain; Region: PilZ; pfam07238
718255002213	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
718255002214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255002215	active site
718255002216	phosphorylation site [posttranslational modification]
718255002217	intermolecular recognition site; other site
718255002218	dimerization interface [polypeptide binding]; other site
718255002219	CheB methylesterase; Region: CheB_methylest; pfam01339
718255002220	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
718255002221	putative binding surface; other site
718255002222	active site
718255002223	P2 response regulator binding domain; Region: P2; pfam07194
718255002224	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
718255002225	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
718255002226	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255002227	ATP binding site [chemical binding]; other site
718255002228	Mg2+ binding site [ion binding]; other site
718255002229	G-X-G motif; other site
718255002230	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
718255002231	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
718255002232	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
718255002233	CheC-like family; Region: CheC; pfam04509
718255002234	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
718255002235	CheC-like family; Region: CheC; pfam04509
718255002236	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488
718255002237	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
718255002238	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718255002239	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
718255002240	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255002241	DNA binding residues [nucleotide binding]
718255002242	YceG-like family; Region: YceG; pfam02618
718255002243	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
718255002244	rRNA interaction site [nucleotide binding]; other site
718255002245	S8 interaction site; other site
718255002246	putative laminin-1 binding site; other site
718255002247	elongation factor Ts; Provisional; Region: tsf; PRK09377
718255002248	UBA/TS-N domain; Region: UBA; pfam00627
718255002249	Elongation factor TS; Region: EF_TS; pfam00889
718255002250	Elongation factor TS; Region: EF_TS; pfam00889
718255002251	Cupin domain; Region: Cupin_2; pfam07883
718255002252	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255002253	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255002254	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255002255	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
718255002256	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
718255002257	Ca binding site [ion binding]; other site
718255002258	active site
718255002259	catalytic site [active]
718255002260	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
718255002261	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
718255002262	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
718255002263	PhoU domain; Region: PhoU; pfam01895
718255002264	PhoU domain; Region: PhoU; pfam01895
718255002265	Domain of unknown function (DUF368); Region: DUF368; pfam04018
718255002266	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
718255002267	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
718255002268	NodB motif; other site
718255002269	active site
718255002270	catalytic site [active]
718255002271	Zn binding site [ion binding]; other site
718255002272	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
718255002273	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
718255002274	putative nucleotide binding site [chemical binding]; other site
718255002275	uridine monophosphate binding site [chemical binding]; other site
718255002276	homohexameric interface [polypeptide binding]; other site
718255002277	ribosome recycling factor; Reviewed; Region: frr; PRK00083
718255002278	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
718255002279	hinge region; other site
718255002280	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
718255002281	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
718255002282	catalytic residue [active]
718255002283	putative FPP diphosphate  binding site; other site
718255002284	putative FPP binding hydrophobic cleft; other site
718255002285	dimer interface [polypeptide binding]; other site
718255002286	putative IPP diphosphate binding site; other site
718255002287	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
718255002288	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
718255002289	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
718255002290	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
718255002291	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
718255002292	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
718255002293	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
718255002294	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
718255002295	active site
718255002296	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
718255002297	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
718255002298	putative substrate binding region [chemical binding]; other site
718255002299	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
718255002300	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
718255002301	generic binding surface II; other site
718255002302	generic binding surface I; other site
718255002303	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
718255002304	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
718255002305	active site
718255002306	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
718255002307	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
718255002308	active site
718255002309	catalytic site [active]
718255002310	substrate binding site [chemical binding]; other site
718255002311	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
718255002312	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
718255002313	Chorismate mutase type II; Region: CM_2; pfam01817
718255002314	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
718255002315	Prephenate dehydratase; Region: PDT; pfam00800
718255002316	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
718255002317	putative L-Phe binding site [chemical binding]; other site
718255002318	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255002319	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
718255002320	Walker A motif; other site
718255002321	ATP binding site [chemical binding]; other site
718255002322	Walker B motif; other site
718255002323	exopolyphosphatase; Region: exo_poly_only; TIGR03706
718255002324	polyphosphate kinase; Provisional; Region: PRK05443
718255002325	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
718255002326	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
718255002327	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
718255002328	putative domain interface [polypeptide binding]; other site
718255002329	putative active site [active]
718255002330	catalytic site [active]
718255002331	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
718255002332	putative domain interface [polypeptide binding]; other site
718255002333	putative active site [active]
718255002334	catalytic site [active]
718255002335	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
718255002336	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255002337	active site
718255002338	motif I; other site
718255002339	motif II; other site
718255002340	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255002341	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
718255002342	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
718255002343	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
718255002344	active site
718255002345	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
718255002346	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
718255002347	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
718255002348	HAMP domain; Region: HAMP; pfam00672
718255002349	dimerization interface [polypeptide binding]; other site
718255002350	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255002351	dimer interface [polypeptide binding]; other site
718255002352	putative CheW interface [polypeptide binding]; other site
718255002353	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
718255002354	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
718255002355	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
718255002356	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
718255002357	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
718255002358	23S rRNA binding site [nucleotide binding]; other site
718255002359	L21 binding site [polypeptide binding]; other site
718255002360	L13 binding site [polypeptide binding]; other site
718255002361	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
718255002362	PHP domain; Region: PHP; pfam02811
718255002363	active site
718255002364	PHP-associated; Region: PHP_C; pfam13263
718255002365	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718255002366	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255002367	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255002368	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255002369	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
718255002370	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
718255002371	FMN binding site [chemical binding]; other site
718255002372	substrate binding site [chemical binding]; other site
718255002373	putative catalytic residue [active]
718255002374	chaperone protein DnaK; Region: prok_dnaK; TIGR02350
718255002375	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
718255002376	nucleotide binding site [chemical binding]; other site
718255002377	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
718255002378	HSP70 interaction site [polypeptide binding]; other site
718255002379	ribosome maturation protein RimP; Reviewed; Region: PRK00092
718255002380	Sm and related proteins; Region: Sm_like; cl00259
718255002381	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
718255002382	putative oligomer interface [polypeptide binding]; other site
718255002383	putative RNA binding site [nucleotide binding]; other site
718255002384	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
718255002385	NusA N-terminal domain; Region: NusA_N; pfam08529
718255002386	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
718255002387	RNA binding site [nucleotide binding]; other site
718255002388	homodimer interface [polypeptide binding]; other site
718255002389	NusA-like KH domain; Region: KH_5; pfam13184
718255002390	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
718255002391	G-X-X-G motif; other site
718255002392	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
718255002393	putative RNA binding cleft [nucleotide binding]; other site
718255002394	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
718255002395	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
718255002396	translation initiation factor IF-2; Region: IF-2; TIGR00487
718255002397	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
718255002398	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
718255002399	G1 box; other site
718255002400	putative GEF interaction site [polypeptide binding]; other site
718255002401	GTP/Mg2+ binding site [chemical binding]; other site
718255002402	Switch I region; other site
718255002403	G2 box; other site
718255002404	G3 box; other site
718255002405	Switch II region; other site
718255002406	G4 box; other site
718255002407	G5 box; other site
718255002408	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
718255002409	Translation-initiation factor 2; Region: IF-2; pfam11987
718255002410	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
718255002411	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
718255002412	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
718255002413	DHH family; Region: DHH; pfam01368
718255002414	DHHA1 domain; Region: DHHA1; pfam02272
718255002415	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
718255002416	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
718255002417	RNA binding site [nucleotide binding]; other site
718255002418	active site
718255002419	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
718255002420	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
718255002421	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
718255002422	active site
718255002423	Riboflavin kinase; Region: Flavokinase; pfam01687
718255002424	Bacterial SH3 domain; Region: SH3_3; pfam08239
718255002425	Bacterial SH3 domain; Region: SH3_3; pfam08239
718255002426	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718255002427	NlpC/P60 family; Region: NLPC_P60; pfam00877
718255002428	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
718255002429	16S/18S rRNA binding site [nucleotide binding]; other site
718255002430	S13e-L30e interaction site [polypeptide binding]; other site
718255002431	25S rRNA binding site [nucleotide binding]; other site
718255002432	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
718255002433	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
718255002434	RNase E interface [polypeptide binding]; other site
718255002435	trimer interface [polypeptide binding]; other site
718255002436	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
718255002437	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
718255002438	RNase E interface [polypeptide binding]; other site
718255002439	trimer interface [polypeptide binding]; other site
718255002440	active site
718255002441	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
718255002442	putative nucleic acid binding region [nucleotide binding]; other site
718255002443	G-X-X-G motif; other site
718255002444	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
718255002445	RNA binding site [nucleotide binding]; other site
718255002446	domain interface; other site
718255002447	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
718255002448	AAA domain; Region: AAA_14; pfam13173
718255002449	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
718255002450	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718255002451	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255002452	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255002453	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255002454	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255002455	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255002456	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255002457	Walker A/P-loop; other site
718255002458	ATP binding site [chemical binding]; other site
718255002459	Q-loop/lid; other site
718255002460	ABC transporter signature motif; other site
718255002461	Walker B; other site
718255002462	D-loop; other site
718255002463	H-loop/switch region; other site
718255002464	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255002465	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255002466	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
718255002467	Walker A/P-loop; other site
718255002468	ATP binding site [chemical binding]; other site
718255002469	Q-loop/lid; other site
718255002470	ABC transporter signature motif; other site
718255002471	Walker B; other site
718255002472	D-loop; other site
718255002473	H-loop/switch region; other site
718255002474	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
718255002475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255002476	active site
718255002477	phosphorylation site [posttranslational modification]
718255002478	intermolecular recognition site; other site
718255002479	dimerization interface [polypeptide binding]; other site
718255002480	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255002481	putative alpha-glucosidase; Provisional; Region: PRK10658
718255002482	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
718255002483	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
718255002484	active site
718255002485	homotrimer interface [polypeptide binding]; other site
718255002486	catalytic site [active]
718255002487	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
718255002488	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255002489	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718255002490	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
718255002491	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255002492	Response regulator receiver domain; Region: Response_reg; pfam00072
718255002493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255002494	active site
718255002495	phosphorylation site [posttranslational modification]
718255002496	intermolecular recognition site; other site
718255002497	dimerization interface [polypeptide binding]; other site
718255002498	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255002499	metal binding site [ion binding]; metal-binding site
718255002500	active site
718255002501	I-site; other site
718255002502	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718255002503	Hpt domain; Region: Hpt; pfam01627
718255002504	putative binding surface; other site
718255002505	active site
718255002506	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
718255002507	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
718255002508	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
718255002509	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
718255002510	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
718255002511	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
718255002512	FAD binding site [chemical binding]; other site
718255002513	Domain of unknown function (DUF4300); Region: DUF4300; pfam14133
718255002514	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
718255002515	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
718255002516	catalytic residues [active]
718255002517	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255002518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255002519	active site
718255002520	phosphorylation site [posttranslational modification]
718255002521	intermolecular recognition site; other site
718255002522	dimerization interface [polypeptide binding]; other site
718255002523	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255002524	DNA binding site [nucleotide binding]
718255002525	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
718255002526	dimer interface [polypeptide binding]; other site
718255002527	substrate binding site [chemical binding]; other site
718255002528	ATP binding site [chemical binding]; other site
718255002529	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
718255002530	Na binding site [ion binding]; other site
718255002531	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
718255002532	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
718255002533	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255002534	Coenzyme A binding pocket [chemical binding]; other site
718255002535	Protein of unknown function DUF111; Region: DUF111; cl03398
718255002536	High-affinity nickel-transport protein; Region: NicO; cl00964
718255002537	Protein of unknown function DUF111; Region: DUF111; pfam01969
718255002538	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
718255002539	AIR carboxylase; Region: AIRC; smart01001
718255002540	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
718255002541	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718255002542	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
718255002543	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718255002544	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718255002545	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718255002546	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
718255002547	MFS/sugar transport protein; Region: MFS_2; pfam13347
718255002548	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
718255002549	Melibiase; Region: Melibiase; pfam02065
718255002550	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
718255002551	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
718255002552	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
718255002553	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
718255002554	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
718255002555	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
718255002556	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
718255002557	glutamine binding [chemical binding]; other site
718255002558	catalytic triad [active]
718255002559	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
718255002560	active site
718255002561	ribulose/triose binding site [chemical binding]; other site
718255002562	phosphate binding site [ion binding]; other site
718255002563	substrate (anthranilate) binding pocket [chemical binding]; other site
718255002564	product (indole) binding pocket [chemical binding]; other site
718255002565	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
718255002566	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
718255002567	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255002568	catalytic residue [active]
718255002569	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
718255002570	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
718255002571	substrate binding site [chemical binding]; other site
718255002572	active site
718255002573	catalytic residues [active]
718255002574	heterodimer interface [polypeptide binding]; other site
718255002575	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
718255002576	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
718255002577	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
718255002578	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
718255002579	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
718255002580	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718255002581	catalytic residue [active]
718255002582	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
718255002583	active site
718255002584	homodimer interface [polypeptide binding]; other site
718255002585	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
718255002586	Protein of unknown function (DUF1284); Region: DUF1284; cl01419
718255002587	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
718255002588	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
718255002589	Cl- selectivity filter; other site
718255002590	Cl- binding residues [ion binding]; other site
718255002591	pore gating glutamate residue; other site
718255002592	dimer interface [polypeptide binding]; other site
718255002593	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
718255002594	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255002595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255002596	dimer interface [polypeptide binding]; other site
718255002597	conserved gate region; other site
718255002598	putative PBP binding loops; other site
718255002599	ABC-ATPase subunit interface; other site
718255002600	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255002601	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255002602	DNA binding site [nucleotide binding]
718255002603	domain linker motif; other site
718255002604	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
718255002605	ligand binding site [chemical binding]; other site
718255002606	dimerization interface [polypeptide binding]; other site
718255002607	4-alpha-glucanotransferase; Provisional; Region: PRK14508
718255002608	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
718255002609	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
718255002610	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
718255002611	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
718255002612	Predicted membrane protein [Function unknown]; Region: COG2364
718255002613	purine nucleoside phosphorylase; Provisional; Region: PRK08202
718255002614	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
718255002615	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
718255002616	active site
718255002617	putative substrate binding pocket [chemical binding]; other site
718255002618	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
718255002619	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
718255002620	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255002621	dimerization interface [polypeptide binding]; other site
718255002622	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255002623	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255002624	dimer interface [polypeptide binding]; other site
718255002625	putative CheW interface [polypeptide binding]; other site
718255002626	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
718255002627	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
718255002628	PilZ domain; Region: PilZ; pfam07238
718255002629	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
718255002630	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255002631	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255002632	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
718255002633	Walker A/P-loop; other site
718255002634	ATP binding site [chemical binding]; other site
718255002635	Q-loop/lid; other site
718255002636	ABC transporter signature motif; other site
718255002637	Walker B; other site
718255002638	D-loop; other site
718255002639	H-loop/switch region; other site
718255002640	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
718255002641	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
718255002642	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
718255002643	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
718255002644	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
718255002645	Hemerythrin; Region: Hemerythrin; cd12107
718255002646	Fe binding site [ion binding]; other site
718255002647	Hemerythrin; Region: Hemerythrin; cd12107
718255002648	Fe binding site [ion binding]; other site
718255002649	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
718255002650	zinc binding site [ion binding]; other site
718255002651	putative ligand binding site [chemical binding]; other site
718255002652	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718255002653	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
718255002654	TM-ABC transporter signature motif; other site
718255002655	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
718255002656	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255002657	Walker A/P-loop; other site
718255002658	ATP binding site [chemical binding]; other site
718255002659	Q-loop/lid; other site
718255002660	ABC transporter signature motif; other site
718255002661	Walker B; other site
718255002662	D-loop; other site
718255002663	H-loop/switch region; other site
718255002664	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
718255002665	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
718255002666	FAD binding pocket [chemical binding]; other site
718255002667	FAD binding motif [chemical binding]; other site
718255002668	phosphate binding motif [ion binding]; other site
718255002669	beta-alpha-beta structure motif; other site
718255002670	NAD binding pocket [chemical binding]; other site
718255002671	Iron coordination center [ion binding]; other site
718255002672	putative oxidoreductase; Provisional; Region: PRK12831
718255002673	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718255002674	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
718255002675	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
718255002676	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718255002677	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255002678	motif II; other site
718255002679	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
718255002680	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
718255002681	Walker A/P-loop; other site
718255002682	ATP binding site [chemical binding]; other site
718255002683	Q-loop/lid; other site
718255002684	ABC transporter signature motif; other site
718255002685	Walker B; other site
718255002686	D-loop; other site
718255002687	H-loop/switch region; other site
718255002688	Predicted transcriptional regulators [Transcription]; Region: COG1725
718255002689	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718255002690	DNA-binding site [nucleotide binding]; DNA binding site
718255002691	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
718255002692	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
718255002693	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255002694	salt bridge; other site
718255002695	non-specific DNA binding site [nucleotide binding]; other site
718255002696	sequence-specific DNA binding site [nucleotide binding]; other site
718255002697	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
718255002698	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
718255002699	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
718255002700	putative ligand binding site [chemical binding]; other site
718255002701	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255002702	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255002703	dimer interface [polypeptide binding]; other site
718255002704	putative CheW interface [polypeptide binding]; other site
718255002705	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
718255002706	nudix motif; other site
718255002707	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
718255002708	active site
718255002709	dimer interfaces [polypeptide binding]; other site
718255002710	catalytic residues [active]
718255002711	EDD domain protein, DegV family; Region: DegV; TIGR00762
718255002712	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
718255002713	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255002714	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718255002715	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255002716	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255002717	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718255002718	dimerization interface [polypeptide binding]; other site
718255002719	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
718255002720	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
718255002721	GDP-binding site [chemical binding]; other site
718255002722	ACT binding site; other site
718255002723	IMP binding site; other site
718255002724	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
718255002725	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255002726	motif II; other site
718255002727	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
718255002728	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
718255002729	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
718255002730	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
718255002731	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
718255002732	MarR family; Region: MarR_2; pfam12802
718255002733	MarR family; Region: MarR_2; cl17246
718255002734	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
718255002735	dimer interface [polypeptide binding]; other site
718255002736	Citrate synthase; Region: Citrate_synt; pfam00285
718255002737	active site
718255002738	citrylCoA binding site [chemical binding]; other site
718255002739	oxalacetate/citrate binding site [chemical binding]; other site
718255002740	coenzyme A binding site [chemical binding]; other site
718255002741	catalytic triad [active]
718255002742	hypothetical protein; Provisional; Region: PRK05590
718255002743	SEC-C motif; Region: SEC-C; pfam02810
718255002744	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
718255002745	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
718255002746	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
718255002747	CHD5-like protein; Region: CHD5; pfam04420
718255002748	Septum formation initiator; Region: DivIC; cl17659
718255002749	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
718255002750	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
718255002751	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
718255002752	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
718255002753	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
718255002754	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
718255002755	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
718255002756	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
718255002757	Mg++ binding site [ion binding]; other site
718255002758	putative catalytic motif [active]
718255002759	putative substrate binding site [chemical binding]; other site
718255002760	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
718255002761	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718255002762	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718255002763	cell division protein FtsW; Region: ftsW; TIGR02614
718255002764	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
718255002765	sporulation sigma factor SigE; Reviewed; Region: PRK08301
718255002766	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718255002767	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255002768	DNA binding residues [nucleotide binding]
718255002769	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
718255002770	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
718255002771	Beta-Casp domain; Region: Beta-Casp; smart01027
718255002772	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
718255002773	sporulation sigma factor SigG; Reviewed; Region: PRK08215
718255002774	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718255002775	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
718255002776	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255002777	DNA binding residues [nucleotide binding]
718255002778	diaminopimelate epimerase; Provisional; Region: PRK13577
718255002779	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
718255002780	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
718255002781	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
718255002782	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718255002783	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
718255002784	NAD(P) binding site [chemical binding]; other site
718255002785	active site
718255002786	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
718255002787	GAF domain; Region: GAF_3; pfam13492
718255002788	Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960
718255002789	Domain of unknown function (DUF3492); Region: DUF3492; pfam11997
718255002790	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
718255002791	Predicted membrane protein [Function unknown]; Region: COG4267
718255002792	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
718255002793	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
718255002794	putative ADP-binding pocket [chemical binding]; other site
718255002795	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
718255002796	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
718255002797	Ligand binding site; other site
718255002798	Putative Catalytic site; other site
718255002799	DXD motif; other site
718255002800	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
718255002801	active site
718255002802	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
718255002803	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
718255002804	putative glycosyl transferase; Provisional; Region: PRK10073
718255002805	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
718255002806	active site
718255002807	Uncharacterized protein conserved in archaea (DUF2120); Region: DUF2120; cl01687
718255002808	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
718255002809	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255002810	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255002811	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255002812	Walker A/P-loop; other site
718255002813	ATP binding site [chemical binding]; other site
718255002814	Q-loop/lid; other site
718255002815	ABC transporter signature motif; other site
718255002816	Walker B; other site
718255002817	D-loop; other site
718255002818	H-loop/switch region; other site
718255002819	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
718255002820	Catalytic site [active]
718255002821	QueT transporter; Region: QueT; pfam06177
718255002822	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
718255002823	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
718255002824	putative active site cavity [active]
718255002825	fructuronate transporter; Provisional; Region: PRK10034; cl15264
718255002826	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
718255002827	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
718255002828	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
718255002829	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
718255002830	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
718255002831	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718255002832	nucleotide binding site [chemical binding]; other site
718255002833	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
718255002834	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
718255002835	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718255002836	active site
718255002837	HIGH motif; other site
718255002838	nucleotide binding site [chemical binding]; other site
718255002839	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
718255002840	KMSK motif region; other site
718255002841	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
718255002842	tRNA binding surface [nucleotide binding]; other site
718255002843	anticodon binding site; other site
718255002844	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
718255002845	Carbon starvation protein CstA; Region: CstA; pfam02554
718255002846	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
718255002847	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
718255002848	NTPase; Region: NTPase_1; cl17478
718255002849	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
718255002850	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
718255002851	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
718255002852	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
718255002853	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
718255002854	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
718255002855	phosphopentomutase; Provisional; Region: PRK05362
718255002856	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
718255002857	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
718255002858	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
718255002859	catalytic residues [active]
718255002860	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
718255002861	recombinase A; Provisional; Region: recA; PRK09354
718255002862	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
718255002863	hexamer interface [polypeptide binding]; other site
718255002864	Walker A motif; other site
718255002865	ATP binding site [chemical binding]; other site
718255002866	Walker B motif; other site
718255002867	Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137
718255002868	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
718255002869	dimer interface [polypeptide binding]; other site
718255002870	ADP-ribose binding site [chemical binding]; other site
718255002871	active site
718255002872	nudix motif; other site
718255002873	metal binding site [ion binding]; metal-binding site
718255002874	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255002875	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
718255002876	active site
718255002877	DNA binding site [nucleotide binding]
718255002878	Int/Topo IB signature motif; other site
718255002879	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
718255002880	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
718255002881	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
718255002882	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
718255002883	active site
718255002884	catalytic residue [active]
718255002885	dimer interface [polypeptide binding]; other site
718255002886	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
718255002887	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718255002888	putative Zn2+ binding site [ion binding]; other site
718255002889	putative DNA binding site [nucleotide binding]; other site
718255002890	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255002891	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255002892	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255002893	Walker A/P-loop; other site
718255002894	ATP binding site [chemical binding]; other site
718255002895	Q-loop/lid; other site
718255002896	ABC transporter signature motif; other site
718255002897	Walker B; other site
718255002898	D-loop; other site
718255002899	H-loop/switch region; other site
718255002900	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255002901	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255002902	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
718255002903	Walker A/P-loop; other site
718255002904	ATP binding site [chemical binding]; other site
718255002905	Q-loop/lid; other site
718255002906	ABC transporter signature motif; other site
718255002907	Walker B; other site
718255002908	D-loop; other site
718255002909	H-loop/switch region; other site
718255002910	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
718255002911	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
718255002912	NAD binding site [chemical binding]; other site
718255002913	dimer interface [polypeptide binding]; other site
718255002914	substrate binding site [chemical binding]; other site
718255002915	tetramer (dimer of dimers) interface [polypeptide binding]; other site
718255002916	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
718255002917	Bacterial SH3 domain; Region: SH3_3; pfam08239
718255002918	Bacterial SH3 domain; Region: SH3_3; pfam08239
718255002919	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
718255002920	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718255002921	RNA binding surface [nucleotide binding]; other site
718255002922	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
718255002923	probable active site [active]
718255002924	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
718255002925	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
718255002926	nucleotide binding pocket [chemical binding]; other site
718255002927	K-X-D-G motif; other site
718255002928	catalytic site [active]
718255002929	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
718255002930	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
718255002931	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
718255002932	Dimer interface [polypeptide binding]; other site
718255002933	Fic family protein [Function unknown]; Region: COG3177
718255002934	Asp23 family; Region: Asp23; pfam03780
718255002935	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
718255002936	putative RNA binding site [nucleotide binding]; other site
718255002937	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
718255002938	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
718255002939	generic binding surface II; other site
718255002940	generic binding surface I; other site
718255002941	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
718255002942	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
718255002943	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
718255002944	substrate binding pocket [chemical binding]; other site
718255002945	chain length determination region; other site
718255002946	substrate-Mg2+ binding site; other site
718255002947	catalytic residues [active]
718255002948	aspartate-rich region 1; other site
718255002949	active site lid residues [active]
718255002950	aspartate-rich region 2; other site
718255002951	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
718255002952	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
718255002953	TPP-binding site; other site
718255002954	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
718255002955	PYR/PP interface [polypeptide binding]; other site
718255002956	dimer interface [polypeptide binding]; other site
718255002957	TPP binding site [chemical binding]; other site
718255002958	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
718255002959	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
718255002960	ATP-NAD kinase; Region: NAD_kinase; pfam01513
718255002961	arginine repressor; Provisional; Region: argR; PRK00441
718255002962	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
718255002963	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
718255002964	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
718255002965	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
718255002966	Walker A/P-loop; other site
718255002967	ATP binding site [chemical binding]; other site
718255002968	Q-loop/lid; other site
718255002969	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
718255002970	ABC transporter signature motif; other site
718255002971	Walker B; other site
718255002972	D-loop; other site
718255002973	H-loop/switch region; other site
718255002974	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718255002975	TPR motif; other site
718255002976	Tetratricopeptide repeat; Region: TPR_12; pfam13424
718255002977	binding surface
718255002978	Tetratricopeptide repeat; Region: TPR_12; pfam13424
718255002979	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255002980	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255002981	metal binding site [ion binding]; metal-binding site
718255002982	active site
718255002983	I-site; other site
718255002984	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
718255002985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255002986	active site
718255002987	phosphorylation site [posttranslational modification]
718255002988	intermolecular recognition site; other site
718255002989	dimerization interface [polypeptide binding]; other site
718255002990	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
718255002991	glycogen synthase; Provisional; Region: glgA; PRK00654
718255002992	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
718255002993	ADP-binding pocket [chemical binding]; other site
718255002994	homodimer interface [polypeptide binding]; other site
718255002995	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
718255002996	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
718255002997	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
718255002998	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255002999	dimer interface [polypeptide binding]; other site
718255003000	conserved gate region; other site
718255003001	putative PBP binding loops; other site
718255003002	ABC-ATPase subunit interface; other site
718255003003	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255003004	dimer interface [polypeptide binding]; other site
718255003005	conserved gate region; other site
718255003006	putative PBP binding loops; other site
718255003007	ABC-ATPase subunit interface; other site
718255003008	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
718255003009	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255003010	Walker A/P-loop; other site
718255003011	ATP binding site [chemical binding]; other site
718255003012	Q-loop/lid; other site
718255003013	ABC transporter signature motif; other site
718255003014	Walker B; other site
718255003015	D-loop; other site
718255003016	H-loop/switch region; other site
718255003017	TOBE domain; Region: TOBE_2; pfam08402
718255003018	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
718255003019	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255003020	non-specific DNA binding site [nucleotide binding]; other site
718255003021	salt bridge; other site
718255003022	sequence-specific DNA binding site [nucleotide binding]; other site
718255003023	Cupin domain; Region: Cupin_2; pfam07883
718255003024	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
718255003025	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
718255003026	ATP-binding site [chemical binding]; other site
718255003027	Sugar specificity; other site
718255003028	Pyrimidine base specificity; other site
718255003029	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
718255003030	active site
718255003031	catalytic triad [active]
718255003032	oxyanion hole [active]
718255003033	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
718255003034	thiS-thiF/thiG interaction site; other site
718255003035	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
718255003036	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
718255003037	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
718255003038	thiamine phosphate binding site [chemical binding]; other site
718255003039	active site
718255003040	pyrophosphate binding site [ion binding]; other site
718255003041	septum formation inhibitor; Reviewed; Region: minC; PRK00513
718255003042	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
718255003043	septum site-determining protein MinD; Region: minD_bact; TIGR01968
718255003044	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
718255003045	Switch I; other site
718255003046	Switch II; other site
718255003047	Septum formation topological specificity factor MinE; Region: MinE; cl00538
718255003048	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
718255003049	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718255003050	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255003051	homodimer interface [polypeptide binding]; other site
718255003052	catalytic residue [active]
718255003053	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
718255003054	active site
718255003055	putative catalytic site [active]
718255003056	DNA binding site [nucleotide binding]
718255003057	putative phosphate binding site [ion binding]; other site
718255003058	metal binding site A [ion binding]; metal-binding site
718255003059	AP binding site [nucleotide binding]; other site
718255003060	metal binding site B [ion binding]; metal-binding site
718255003061	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
718255003062	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
718255003063	catalytic loop [active]
718255003064	iron binding site [ion binding]; other site
718255003065	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
718255003066	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718255003067	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255003068	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255003069	dimer interface [polypeptide binding]; other site
718255003070	conserved gate region; other site
718255003071	putative PBP binding loops; other site
718255003072	ABC-ATPase subunit interface; other site
718255003073	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255003074	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718255003075	Protein of unknown function, DUF624; Region: DUF624; pfam04854
718255003076	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
718255003077	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
718255003078	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
718255003079	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
718255003080	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
718255003081	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
718255003082	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
718255003083	HAMP domain; Region: HAMP; pfam00672
718255003084	dimerization interface [polypeptide binding]; other site
718255003085	Histidine kinase; Region: His_kinase; pfam06580
718255003086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255003087	ATP binding site [chemical binding]; other site
718255003088	Mg2+ binding site [ion binding]; other site
718255003089	G-X-G motif; other site
718255003090	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255003091	cobyric acid synthase; Provisional; Region: PRK00784
718255003092	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
718255003093	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
718255003094	catalytic triad [active]
718255003095	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
718255003096	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
718255003097	putative dimer interface [polypeptide binding]; other site
718255003098	active site pocket [active]
718255003099	putative cataytic base [active]
718255003100	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718255003101	Walker A motif; other site
718255003102	ATP binding site [chemical binding]; other site
718255003103	Walker B motif; other site
718255003104	cobalamin synthase; Reviewed; Region: cobS; PRK00235
718255003105	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
718255003106	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718255003107	catalytic core [active]
718255003108	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
718255003109	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
718255003110	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255003111	Zn2+ binding site [ion binding]; other site
718255003112	Mg2+ binding site [ion binding]; other site
718255003113	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
718255003114	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
718255003115	argininosuccinate lyase; Provisional; Region: PRK00855
718255003116	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
718255003117	active sites [active]
718255003118	tetramer interface [polypeptide binding]; other site
718255003119	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
718255003120	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
718255003121	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
718255003122	Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636
718255003123	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255003124	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255003125	dimer interface [polypeptide binding]; other site
718255003126	putative CheW interface [polypeptide binding]; other site
718255003127	YARHG domain; Region: YARHG; pfam13308
718255003128	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
718255003129	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
718255003130	GGGtGRT protein; Region: GGGtGRT; pfam14057
718255003131	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
718255003132	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
718255003133	active site
718255003134	DNA binding site [nucleotide binding]
718255003135	Predicted membrane protein [Function unknown]; Region: COG1511
718255003136	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
718255003137	Allexivirus 40kDa protein; Region: Allexi_40kDa; pfam05549
718255003138	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
718255003139	Predicted membrane protein [Function unknown]; Region: COG1511
718255003140	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
718255003141	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
718255003142	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
718255003143	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
718255003144	putative valine binding site [chemical binding]; other site
718255003145	dimer interface [polypeptide binding]; other site
718255003146	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
718255003147	ketol-acid reductoisomerase; Provisional; Region: PRK05479
718255003148	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
718255003149	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
718255003150	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
718255003151	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
718255003152	HIGH motif; other site
718255003153	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
718255003154	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718255003155	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718255003156	active site
718255003157	KMSKS motif; other site
718255003158	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
718255003159	tRNA binding surface [nucleotide binding]; other site
718255003160	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255003161	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718255003162	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255003163	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255003164	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718255003165	dimerization interface [polypeptide binding]; other site
718255003166	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
718255003167	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
718255003168	substrate binding site [chemical binding]; other site
718255003169	ligand binding site [chemical binding]; other site
718255003170	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
718255003171	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
718255003172	substrate binding site [chemical binding]; other site
718255003173	Cupin domain; Region: Cupin_2; pfam07883
718255003174	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255003175	1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336
718255003176	Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508
718255003177	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255003178	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718255003179	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
718255003180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255003181	dimer interface [polypeptide binding]; other site
718255003182	conserved gate region; other site
718255003183	putative PBP binding loops; other site
718255003184	ABC-ATPase subunit interface; other site
718255003185	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255003186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255003187	dimer interface [polypeptide binding]; other site
718255003188	conserved gate region; other site
718255003189	putative PBP binding loops; other site
718255003190	ABC-ATPase subunit interface; other site
718255003191	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
718255003192	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
718255003193	ApbE family; Region: ApbE; pfam02424
718255003194	gamma-glutamyl kinase; Provisional; Region: PRK05429
718255003195	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
718255003196	nucleotide binding site [chemical binding]; other site
718255003197	homotetrameric interface [polypeptide binding]; other site
718255003198	putative phosphate binding site [ion binding]; other site
718255003199	putative allosteric binding site; other site
718255003200	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
718255003201	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
718255003202	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
718255003203	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
718255003204	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
718255003205	putative catalytic cysteine [active]
718255003206	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
718255003207	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
718255003208	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255003209	FeS/SAM binding site; other site
718255003210	TRAM domain; Region: TRAM; pfam01938
718255003211	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
718255003212	trimer interface [polypeptide binding]; other site
718255003213	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
718255003214	RuvA N terminal domain; Region: RuvA_N; pfam01330
718255003215	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
718255003216	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
718255003217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255003218	Walker A motif; other site
718255003219	ATP binding site [chemical binding]; other site
718255003220	Walker B motif; other site
718255003221	arginine finger; other site
718255003222	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
718255003223	Cell division protein ZapA; Region: ZapA; pfam05164
718255003224	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
718255003225	Peptidase family U32; Region: Peptidase_U32; pfam01136
718255003226	Collagenase; Region: DUF3656; pfam12392
718255003227	Peptidase family U32; Region: Peptidase_U32; cl03113
718255003228	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
718255003229	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
718255003230	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
718255003231	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
718255003232	active site
718255003233	Ap6A binding site [chemical binding]; other site
718255003234	nudix motif; other site
718255003235	metal binding site [ion binding]; metal-binding site
718255003236	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; pfam09579
718255003237	hypothetical protein; Provisional; Region: PRK09273
718255003238	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
718255003239	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
718255003240	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
718255003241	Glucuronate isomerase; Region: UxaC; pfam02614
718255003242	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
718255003243	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255003244	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255003245	DNA binding site [nucleotide binding]
718255003246	domain linker motif; other site
718255003247	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
718255003248	dimerization interface [polypeptide binding]; other site
718255003249	ligand binding site [chemical binding]; other site
718255003250	altronate oxidoreductase; Provisional; Region: PRK03643
718255003251	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
718255003252	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
718255003253	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
718255003254	galactarate dehydratase; Region: galactar-dH20; TIGR03248
718255003255	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
718255003256	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
718255003257	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
718255003258	NADP binding site [chemical binding]; other site
718255003259	homodimer interface [polypeptide binding]; other site
718255003260	active site
718255003261	Beta-lactamase; Region: Beta-lactamase; pfam00144
718255003262	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
718255003263	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255003264	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255003265	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255003266	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718255003267	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255003268	dimer interface [polypeptide binding]; other site
718255003269	conserved gate region; other site
718255003270	putative PBP binding loops; other site
718255003271	ABC-ATPase subunit interface; other site
718255003272	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255003273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255003274	conserved gate region; other site
718255003275	ABC-ATPase subunit interface; other site
718255003276	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
718255003277	active site
718255003278	catalytic triad [active]
718255003279	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
718255003280	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
718255003281	active site
718255003282	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
718255003283	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
718255003284	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
718255003285	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
718255003286	inhibitor binding site; inhibition site
718255003287	active site
718255003288	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
718255003289	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
718255003290	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
718255003291	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
718255003292	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
718255003293	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
718255003294	Asp23 family; Region: Asp23; pfam03780
718255003295	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
718255003296	Y-family of DNA polymerases; Region: PolY; cl12025
718255003297	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
718255003298	ssDNA binding site; other site
718255003299	generic binding surface II; other site
718255003300	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718255003301	ATP binding site [chemical binding]; other site
718255003302	putative Mg++ binding site [ion binding]; other site
718255003303	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718255003304	nucleotide binding region [chemical binding]; other site
718255003305	ATP-binding site [chemical binding]; other site
718255003306	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
718255003307	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
718255003308	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
718255003309	Domain of unknown function (DUF814); Region: DUF814; pfam05670
718255003310	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
718255003311	Switch I region; other site
718255003312	G3 box; other site
718255003313	Switch II region; other site
718255003314	oligoendopeptidase F; Region: pepF; TIGR00181
718255003315	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
718255003316	active site
718255003317	Zn binding site [ion binding]; other site
718255003318	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
718255003319	Quinolinate synthetase A protein; Region: NadA; pfam02445
718255003320	L-aspartate oxidase; Provisional; Region: PRK06175
718255003321	FAD binding domain; Region: FAD_binding_2; pfam00890
718255003322	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
718255003323	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
718255003324	dimerization interface [polypeptide binding]; other site
718255003325	active site
718255003326	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
718255003327	HTH domain; Region: HTH_11; pfam08279
718255003328	3H domain; Region: 3H; pfam02829
718255003329	Domain of unknown function (DUF370); Region: DUF370; cl00898
718255003330	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
718255003331	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
718255003332	catalytic site [active]
718255003333	G-X2-G-X-G-K; other site
718255003334	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
718255003335	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
718255003336	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255003337	FeS/SAM binding site; other site
718255003338	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
718255003339	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
718255003340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255003341	S-adenosylmethionine binding site [chemical binding]; other site
718255003342	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
718255003343	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
718255003344	active site
718255003345	(T/H)XGH motif; other site
718255003346	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
718255003347	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
718255003348	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
718255003349	metal binding site [ion binding]; metal-binding site
718255003350	dimer interface [polypeptide binding]; other site
718255003351	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
718255003352	Peptidase family M23; Region: Peptidase_M23; pfam01551
718255003353	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
718255003354	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718255003355	RNA binding surface [nucleotide binding]; other site
718255003356	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
718255003357	active site
718255003358	uracil binding [chemical binding]; other site
718255003359	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
718255003360	hypothetical protein; Provisional; Region: PRK00955
718255003361	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
718255003362	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
718255003363	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718255003364	RNA binding surface [nucleotide binding]; other site
718255003365	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
718255003366	active site
718255003367	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
718255003368	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
718255003369	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
718255003370	dimer interface [polypeptide binding]; other site
718255003371	motif 1; other site
718255003372	active site
718255003373	motif 2; other site
718255003374	motif 3; other site
718255003375	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
718255003376	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
718255003377	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
718255003378	histidinol dehydrogenase; Region: hisD; TIGR00069
718255003379	NAD binding site [chemical binding]; other site
718255003380	dimerization interface [polypeptide binding]; other site
718255003381	product binding site; other site
718255003382	substrate binding site [chemical binding]; other site
718255003383	zinc binding site [ion binding]; other site
718255003384	catalytic residues [active]
718255003385	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
718255003386	putative active site pocket [active]
718255003387	4-fold oligomerization interface [polypeptide binding]; other site
718255003388	metal binding residues [ion binding]; metal-binding site
718255003389	3-fold/trimer interface [polypeptide binding]; other site
718255003390	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
718255003391	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
718255003392	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
718255003393	metal binding site [ion binding]; metal-binding site
718255003394	Divergent AAA domain; Region: AAA_4; pfam04326
718255003395	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
718255003396	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
718255003397	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
718255003398	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
718255003399	Acyltransferase family; Region: Acyl_transf_3; pfam01757
718255003400	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
718255003401	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
718255003402	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
718255003403	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
718255003404	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
718255003405	homodimer interface [polypeptide binding]; other site
718255003406	oligonucleotide binding site [chemical binding]; other site
718255003407	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
718255003408	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
718255003409	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
718255003410	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
718255003411	Protein of unknown function (DUF464); Region: DUF464; pfam04327
718255003412	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
718255003413	GTPase CgtA; Reviewed; Region: obgE; PRK12297
718255003414	GTP1/OBG; Region: GTP1_OBG; pfam01018
718255003415	Obg GTPase; Region: Obg; cd01898
718255003416	G1 box; other site
718255003417	GTP/Mg2+ binding site [chemical binding]; other site
718255003418	Switch I region; other site
718255003419	G2 box; other site
718255003420	G3 box; other site
718255003421	Switch II region; other site
718255003422	G4 box; other site
718255003423	G5 box; other site
718255003424	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
718255003425	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
718255003426	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
718255003427	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
718255003428	active site
718255003429	(T/H)XGH motif; other site
718255003430	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255003431	Zn2+ binding site [ion binding]; other site
718255003432	Mg2+ binding site [ion binding]; other site
718255003433	Oligomerisation domain; Region: Oligomerisation; pfam02410
718255003434	LexA repressor; Validated; Region: PRK00215
718255003435	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718255003436	putative DNA binding site [nucleotide binding]; other site
718255003437	putative Zn2+ binding site [ion binding]; other site
718255003438	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
718255003439	Catalytic site [active]
718255003440	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
718255003441	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
718255003442	putative acyl-acceptor binding pocket; other site
718255003443	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
718255003444	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255003445	active site
718255003446	Int/Topo IB signature motif; other site
718255003447	DNA binding site [nucleotide binding]
718255003448	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
718255003449	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
718255003450	lipoprotein signal peptidase; Provisional; Region: PRK14787
718255003451	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
718255003452	active site
718255003453	dimer interface [polypeptide binding]; other site
718255003454	metal binding site [ion binding]; metal-binding site
718255003455	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
718255003456	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718255003457	RNA binding surface [nucleotide binding]; other site
718255003458	Protein of unknown function (DUF552); Region: DUF552; pfam04472
718255003459	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
718255003460	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718255003461	catalytic residue [active]
718255003462	Uncharacterized conserved protein [Function unknown]; Region: COG2155
718255003463	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
718255003464	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
718255003465	methylglyoxal synthase; Validated; Region: mgsA; PRK05234
718255003466	substrate binding site [chemical binding]; other site
718255003467	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
718255003468	Septum formation topological specificity factor MinE; Region: MinE; cl00538
718255003469	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
718255003470	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
718255003471	Switch II; other site
718255003472	rod shape-determining protein MreC; Provisional; Region: PRK13922
718255003473	rod shape-determining protein MreC; Region: MreC; pfam04085
718255003474	rod shape-determining protein MreB; Provisional; Region: PRK13927
718255003475	MreB and similar proteins; Region: MreB_like; cd10225
718255003476	nucleotide binding site [chemical binding]; other site
718255003477	Mg binding site [ion binding]; other site
718255003478	putative protofilament interaction site [polypeptide binding]; other site
718255003479	RodZ interaction site [polypeptide binding]; other site
718255003480	hypothetical protein; Reviewed; Region: PRK00024
718255003481	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
718255003482	MPN+ (JAMM) motif; other site
718255003483	Zinc-binding site [ion binding]; other site
718255003484	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
718255003485	Aluminium resistance protein; Region: Alum_res; pfam06838
718255003486	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
718255003487	IPP transferase; Region: IPPT; pfam01715
718255003488	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
718255003489	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255003490	ATP binding site [chemical binding]; other site
718255003491	Mg2+ binding site [ion binding]; other site
718255003492	G-X-G motif; other site
718255003493	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
718255003494	ATP binding site [chemical binding]; other site
718255003495	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
718255003496	Thymidylate synthase complementing protein; Region: Thy1; cl03630
718255003497	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
718255003498	MutS domain I; Region: MutS_I; pfam01624
718255003499	MutS domain II; Region: MutS_II; pfam05188
718255003500	MutS domain III; Region: MutS_III; pfam05192
718255003501	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
718255003502	Walker A/P-loop; other site
718255003503	ATP binding site [chemical binding]; other site
718255003504	Q-loop/lid; other site
718255003505	ABC transporter signature motif; other site
718255003506	Walker B; other site
718255003507	D-loop; other site
718255003508	H-loop/switch region; other site
718255003509	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
718255003510	flavoprotein, HI0933 family; Region: TIGR00275
718255003511	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718255003512	BofC C-terminal domain; Region: BofC_C; pfam08955
718255003513	stage V sporulation protein B; Region: spore_V_B; TIGR02900
718255003514	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
718255003515	metal-binding heat shock protein; Provisional; Region: PRK00016
718255003516	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
718255003517	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
718255003518	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
718255003519	PhoH-like protein; Region: PhoH; pfam02562
718255003520	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
718255003521	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
718255003522	YabP family; Region: YabP; cl06766
718255003523	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
718255003524	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
718255003525	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
718255003526	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
718255003527	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
718255003528	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
718255003529	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
718255003530	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
718255003531	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
718255003532	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
718255003533	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
718255003534	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
718255003535	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
718255003536	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
718255003537	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
718255003538	minor groove reading motif; other site
718255003539	helix-hairpin-helix signature motif; other site
718255003540	substrate binding pocket [chemical binding]; other site
718255003541	active site
718255003542	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
718255003543	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
718255003544	Na binding site [ion binding]; other site
718255003545	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
718255003546	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
718255003547	inhibitor binding site; inhibition site
718255003548	active site
718255003549	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
718255003550	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
718255003551	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718255003552	binding surface
718255003553	Tetratricopeptide repeat; Region: TPR_16; pfam13432
718255003554	TPR motif; other site
718255003555	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
718255003556	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
718255003557	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
718255003558	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
718255003559	Potassium binding sites [ion binding]; other site
718255003560	Cesium cation binding sites [ion binding]; other site
718255003561	Bacitracin resistance protein BacA; Region: BacA; pfam02673
718255003562	Clp protease; Region: CLP_protease; pfam00574
718255003563	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
718255003564	active site
718255003565	glycogen synthase; Provisional; Region: glgA; PRK00654
718255003566	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
718255003567	ADP-binding pocket [chemical binding]; other site
718255003568	homodimer interface [polypeptide binding]; other site
718255003569	hypothetical protein; Validated; Region: PRK00110
718255003570	Transcriptional regulator; Region: Transcrip_reg; cl00361
718255003571	PemK-like protein; Region: PemK; pfam02452
718255003572	alanine racemase; Reviewed; Region: alr; PRK00053
718255003573	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
718255003574	active site
718255003575	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718255003576	dimer interface [polypeptide binding]; other site
718255003577	substrate binding site [chemical binding]; other site
718255003578	catalytic residues [active]
718255003579	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
718255003580	putative carbohydrate kinase; Provisional; Region: PRK10565
718255003581	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
718255003582	putative substrate binding site [chemical binding]; other site
718255003583	putative ATP binding site [chemical binding]; other site
718255003584	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
718255003585	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718255003586	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718255003587	ABC transporter; Region: ABC_tran_2; pfam12848
718255003588	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718255003589	isocitrate dehydrogenase; Validated; Region: PRK08299
718255003590	Transcriptional regulators [Transcription]; Region: FadR; COG2186
718255003591	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718255003592	DNA-binding site [nucleotide binding]; DNA binding site
718255003593	FCD domain; Region: FCD; pfam07729
718255003594	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
718255003595	Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947
718255003596	active site
718255003597	catalytic residues [active]
718255003598	metal binding site [ion binding]; metal-binding site
718255003599	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
718255003600	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
718255003601	elongation factor G; Reviewed; Region: PRK12740
718255003602	G1 box; other site
718255003603	putative GEF interaction site [polypeptide binding]; other site
718255003604	GTP/Mg2+ binding site [chemical binding]; other site
718255003605	Switch I region; other site
718255003606	G2 box; other site
718255003607	G3 box; other site
718255003608	Switch II region; other site
718255003609	G4 box; other site
718255003610	G5 box; other site
718255003611	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
718255003612	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
718255003613	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
718255003614	prephenate dehydrogenase; Validated; Region: PRK08507
718255003615	prephenate dehydrogenase; Validated; Region: PRK06545
718255003616	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
718255003617	AAA domain; Region: AAA_21; pfam13304
718255003618	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
718255003619	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
718255003620	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
718255003621	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
718255003622	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
718255003623	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
718255003624	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
718255003625	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
718255003626	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
718255003627	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
718255003628	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
718255003629	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
718255003630	putative tRNA-binding site [nucleotide binding]; other site
718255003631	B3/4 domain; Region: B3_4; pfam03483
718255003632	tRNA synthetase B5 domain; Region: B5; pfam03484
718255003633	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
718255003634	dimer interface [polypeptide binding]; other site
718255003635	motif 1; other site
718255003636	motif 3; other site
718255003637	motif 2; other site
718255003638	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
718255003639	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
718255003640	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
718255003641	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
718255003642	dimer interface [polypeptide binding]; other site
718255003643	motif 1; other site
718255003644	active site
718255003645	motif 2; other site
718255003646	motif 3; other site
718255003647	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
718255003648	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
718255003649	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
718255003650	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
718255003651	active site
718255003652	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
718255003653	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
718255003654	active site
718255003655	substrate-binding site [chemical binding]; other site
718255003656	metal-binding site [ion binding]
718255003657	ATP binding site [chemical binding]; other site
718255003658	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255003659	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255003660	dimer interface [polypeptide binding]; other site
718255003661	putative CheW interface [polypeptide binding]; other site
718255003662	Uncharacterized conserved protein [Function unknown]; Region: COG3287
718255003663	FIST N domain; Region: FIST; cl10701
718255003664	FIST C domain; Region: FIST_C; pfam10442
718255003665	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
718255003666	active site
718255003667	catalytic motif [active]
718255003668	Zn binding site [ion binding]; other site
718255003669	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
718255003670	dimer interface [polypeptide binding]; other site
718255003671	Citrate synthase; Region: Citrate_synt; pfam00285
718255003672	active site
718255003673	citrylCoA binding site [chemical binding]; other site
718255003674	oxalacetate/citrate binding site [chemical binding]; other site
718255003675	coenzyme A binding site [chemical binding]; other site
718255003676	catalytic triad [active]
718255003677	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255003678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255003679	active site
718255003680	phosphorylation site [posttranslational modification]
718255003681	intermolecular recognition site; other site
718255003682	dimerization interface [polypeptide binding]; other site
718255003683	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255003684	DNA binding site [nucleotide binding]
718255003685	Response regulator receiver domain; Region: Response_reg; pfam00072
718255003686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255003687	active site
718255003688	phosphorylation site [posttranslational modification]
718255003689	intermolecular recognition site; other site
718255003690	dimerization interface [polypeptide binding]; other site
718255003691	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
718255003692	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
718255003693	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
718255003694	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255003695	catalytic residue [active]
718255003696	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255003697	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255003698	dimer interface [polypeptide binding]; other site
718255003699	putative CheW interface [polypeptide binding]; other site
718255003700	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
718255003701	4Fe-4S binding domain; Region: Fer4; pfam00037
718255003702	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
718255003703	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255003704	dimer interface [polypeptide binding]; other site
718255003705	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
718255003706	putative CheW interface [polypeptide binding]; other site
718255003707	Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878
718255003708	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718255003709	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
718255003710	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
718255003711	electron transport complex RsxE subunit; Provisional; Region: PRK12405
718255003712	FMN-binding domain; Region: FMN_bind; cl01081
718255003713	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
718255003714	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
718255003715	SLBB domain; Region: SLBB; pfam10531
718255003716	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718255003717	RNase_H superfamily; Region: RNase_H_2; pfam13482
718255003718	active site
718255003719	catalytic site [active]
718255003720	substrate binding site [chemical binding]; other site
718255003721	Leucine rich repeat; Region: LRR_8; pfam13855
718255003722	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
718255003723	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
718255003724	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
718255003725	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
718255003726	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
718255003727	RNA binding site [nucleotide binding]; other site
718255003728	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
718255003729	RNA binding site [nucleotide binding]; other site
718255003730	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
718255003731	RNA binding site [nucleotide binding]; other site
718255003732	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
718255003733	RNA binding site [nucleotide binding]; other site
718255003734	LytB protein; Region: LYTB; cl00507
718255003735	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
718255003736	cytidylate kinase; Provisional; Region: cmk; PRK00023
718255003737	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
718255003738	CMP-binding site; other site
718255003739	The sites determining sugar specificity; other site
718255003740	flavoprotein, HI0933 family; Region: TIGR00275
718255003741	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
718255003742	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
718255003743	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
718255003744	putative active site [active]
718255003745	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255003746	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255003747	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255003748	Walker A/P-loop; other site
718255003749	ATP binding site [chemical binding]; other site
718255003750	Q-loop/lid; other site
718255003751	ABC transporter signature motif; other site
718255003752	Walker B; other site
718255003753	D-loop; other site
718255003754	H-loop/switch region; other site
718255003755	oxaloacetate decarboxylase; Provisional; Region: PRK12331
718255003756	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
718255003757	active site
718255003758	catalytic residues [active]
718255003759	metal binding site [ion binding]; metal-binding site
718255003760	homodimer binding site [polypeptide binding]; other site
718255003761	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
718255003762	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
718255003763	carboxyltransferase (CT) interaction site; other site
718255003764	biotinylation site [posttranslational modification]; other site
718255003765	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
718255003766	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
718255003767	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
718255003768	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
718255003769	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
718255003770	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
718255003771	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
718255003772	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
718255003773	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
718255003774	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
718255003775	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255003776	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255003777	catalytic residues [active]
718255003778	catalytic nucleophile [active]
718255003779	Recombinase; Region: Recombinase; pfam07508
718255003780	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255003781	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255003782	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255003783	catalytic residues [active]
718255003784	catalytic nucleophile [active]
718255003785	Recombinase; Region: Recombinase; pfam07508
718255003786	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255003787	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255003788	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255003789	catalytic residues [active]
718255003790	catalytic nucleophile [active]
718255003791	Recombinase; Region: Recombinase; pfam07508
718255003792	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255003793	Accessory gene regulator B; Region: AgrB; pfam04647
718255003794	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
718255003795	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
718255003796	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
718255003797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255003798	active site
718255003799	phosphorylation site [posttranslational modification]
718255003800	intermolecular recognition site; other site
718255003801	dimerization interface [polypeptide binding]; other site
718255003802	LytTr DNA-binding domain; Region: LytTR; pfam04397
718255003803	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255003804	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255003805	non-specific DNA binding site [nucleotide binding]; other site
718255003806	salt bridge; other site
718255003807	sequence-specific DNA binding site [nucleotide binding]; other site
718255003808	Transposase; Region: DEDD_Tnp_IS110; pfam01548
718255003809	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
718255003810	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
718255003811	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
718255003812	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
718255003813	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
718255003814	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
718255003815	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
718255003816	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
718255003817	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
718255003818	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
718255003819	Sel1-like repeats; Region: SEL1; smart00671
718255003820	Sel1-like repeats; Region: SEL1; smart00671
718255003821	Sel1-like repeats; Region: SEL1; smart00671
718255003822	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
718255003823	Sel1-like repeats; Region: SEL1; smart00671
718255003824	Sel1-like repeats; Region: SEL1; smart00671
718255003825	Sel1-like repeats; Region: SEL1; smart00671
718255003826	PIN domain; Region: PIN_3; pfam13470
718255003827	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718255003828	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
718255003829	cofactor binding site; other site
718255003830	DNA binding site [nucleotide binding]
718255003831	substrate interaction site [chemical binding]; other site
718255003832	Mor transcription activator family; Region: Mor; cl02360
718255003833	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
718255003834	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
718255003835	Transglycosylase; Region: Transgly; pfam00912
718255003836	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
718255003837	Uncharacterized conserved protein [Function unknown]; Region: COG1739
718255003838	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
718255003839	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
718255003840	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
718255003841	active site
718255003842	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
718255003843	S1 domain; Region: S1_2; pfam13509
718255003844	S1 domain; Region: S1_2; pfam13509
718255003845	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
718255003846	RNA binding site [nucleotide binding]; other site
718255003847	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
718255003848	homotrimer interaction site [polypeptide binding]; other site
718255003849	putative active site [active]
718255003850	Putative motility protein; Region: YjfB_motility; pfam14070
718255003851	Bacterial SH3 domain; Region: SH3_3; pfam08239
718255003852	Bacterial SH3 domain; Region: SH3_3; pfam08239
718255003853	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718255003854	NlpC/P60 family; Region: NLPC_P60; pfam00877
718255003855	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
718255003856	Carbon starvation protein CstA; Region: CstA; pfam02554
718255003857	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
718255003858	Glycosyl transferase WecB/TagA/CpsF family; Region: Glyco_tran_WecB; pfam03808
718255003859	Uncharacterized conserved protein [Function unknown]; Region: COG1284
718255003860	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
718255003861	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
718255003862	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
718255003863	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
718255003864	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255003865	Walker A/P-loop; other site
718255003866	ATP binding site [chemical binding]; other site
718255003867	Q-loop/lid; other site
718255003868	ABC transporter signature motif; other site
718255003869	Walker B; other site
718255003870	D-loop; other site
718255003871	H-loop/switch region; other site
718255003872	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
718255003873	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
718255003874	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
718255003875	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
718255003876	Peptidase family M23; Region: Peptidase_M23; pfam01551
718255003877	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
718255003878	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
718255003879	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
718255003880	protein binding site [polypeptide binding]; other site
718255003881	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
718255003882	Catalytic dyad [active]
718255003883	Predicted integral membrane protein [Function unknown]; Region: COG5652
718255003884	peptide chain release factor 2; Provisional; Region: PRK05589
718255003885	PCRF domain; Region: PCRF; pfam03462
718255003886	RF-1 domain; Region: RF-1; pfam00472
718255003887	Tim44-like domain; Region: Tim44; cl09208
718255003888	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
718255003889	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
718255003890	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
718255003891	Double zinc ribbon; Region: DZR; pfam12773
718255003892	Repair protein; Region: Repair_PSII; pfam04536
718255003893	hypothetical protein; Provisional; Region: PRK04435
718255003894	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
718255003895	DNA-binding interface [nucleotide binding]; DNA binding site
718255003896	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
718255003897	homoserine dehydrogenase; Provisional; Region: PRK06349
718255003898	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
718255003899	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
718255003900	carbamoyl-phosphate synthase, small subunit; Region: CPSaseIIsmall; TIGR01368
718255003901	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
718255003902	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
718255003903	catalytic site [active]
718255003904	subunit interface [polypeptide binding]; other site
718255003905	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
718255003906	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
718255003907	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
718255003908	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
718255003909	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
718255003910	ATP-grasp domain; Region: ATP-grasp_4; cl17255
718255003911	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
718255003912	IMP binding site; other site
718255003913	dimer interface [polypeptide binding]; other site
718255003914	interdomain contacts; other site
718255003915	partial ornithine binding site; other site
718255003916	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
718255003917	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255003918	Zn2+ binding site [ion binding]; other site
718255003919	Mg2+ binding site [ion binding]; other site
718255003920	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
718255003921	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
718255003922	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
718255003923	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
718255003924	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
718255003925	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
718255003926	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
718255003927	FAD binding site [chemical binding]; other site
718255003928	homotetramer interface [polypeptide binding]; other site
718255003929	substrate binding pocket [chemical binding]; other site
718255003930	catalytic base [active]
718255003931	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
718255003932	Ligand binding site [chemical binding]; other site
718255003933	Electron transfer flavoprotein domain; Region: ETF; pfam01012
718255003934	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
718255003935	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
718255003936	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
718255003937	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
718255003938	Predicted membrane protein [Function unknown]; Region: COG4684
718255003939	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
718255003940	ApbE family; Region: ApbE; pfam02424
718255003941	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
718255003942	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
718255003943	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255003944	non-specific DNA binding site [nucleotide binding]; other site
718255003945	salt bridge; other site
718255003946	sequence-specific DNA binding site [nucleotide binding]; other site
718255003947	AAA domain; Region: AAA_21; pfam13304
718255003948	RloB-like protein; Region: RloB; pfam13707
718255003949	AAA domain; Region: AAA_21; pfam13304
718255003950	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255003951	Walker B; other site
718255003952	D-loop; other site
718255003953	H-loop/switch region; other site
718255003954	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255003955	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
718255003956	catalytic residues [active]
718255003957	catalytic nucleophile [active]
718255003958	Recombinase; Region: Recombinase; pfam07508
718255003959	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255003960	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
718255003961	GMP synthase; Reviewed; Region: guaA; PRK00074
718255003962	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
718255003963	AMP/PPi binding site [chemical binding]; other site
718255003964	candidate oxyanion hole; other site
718255003965	catalytic triad [active]
718255003966	potential glutamine specificity residues [chemical binding]; other site
718255003967	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
718255003968	ATP Binding subdomain [chemical binding]; other site
718255003969	Ligand Binding sites [chemical binding]; other site
718255003970	Dimerization subdomain; other site
718255003971	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255003972	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255003973	non-specific DNA binding site [nucleotide binding]; other site
718255003974	salt bridge; other site
718255003975	sequence-specific DNA binding site [nucleotide binding]; other site
718255003976	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
718255003977	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
718255003978	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
718255003979	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
718255003980	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255003981	Coenzyme A binding pocket [chemical binding]; other site
718255003982	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718255003983	catalytic core [active]
718255003984	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
718255003985	Part of AAA domain; Region: AAA_19; pfam13245
718255003986	AAA domain; Region: AAA_12; pfam13087
718255003987	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
718255003988	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
718255003989	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
718255003990	nudix motif; other site
718255003991	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
718255003992	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255003993	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
718255003994	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255003995	DNA binding residues [nucleotide binding]
718255003996	hypothetical protein; Provisional; Region: PRK13795
718255003997	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
718255003998	Active Sites [active]
718255003999	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
718255004000	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255004001	metal binding site [ion binding]; metal-binding site
718255004002	active site
718255004003	I-site; other site
718255004004	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718255004005	FMN-binding domain; Region: FMN_bind; cl01081
718255004006	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
718255004007	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
718255004008	folate binding site [chemical binding]; other site
718255004009	NADP+ binding site [chemical binding]; other site
718255004010	Predicted permeases [General function prediction only]; Region: COG0679
718255004011	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
718255004012	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
718255004013	PYR/PP interface [polypeptide binding]; other site
718255004014	dimer interface [polypeptide binding]; other site
718255004015	TPP binding site [chemical binding]; other site
718255004016	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
718255004017	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
718255004018	TPP-binding site [chemical binding]; other site
718255004019	dimer interface [polypeptide binding]; other site
718255004020	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
718255004021	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
718255004022	putative valine binding site [chemical binding]; other site
718255004023	dimer interface [polypeptide binding]; other site
718255004024	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
718255004025	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
718255004026	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
718255004027	dimerization interface [polypeptide binding]; other site
718255004028	domain crossover interface; other site
718255004029	redox-dependent activation switch; other site
718255004030	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
718255004031	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718255004032	active site
718255004033	catalytic tetrad [active]
718255004034	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718255004035	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
718255004036	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
718255004037	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
718255004038	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
718255004039	stage V sporulation protein AD; Provisional; Region: PRK12404
718255004040	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
718255004041	SpoVA protein; Region: SpoVA; pfam03862
718255004042	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
718255004043	nucleotide binding site/active site [active]
718255004044	HIT family signature motif; other site
718255004045	catalytic residue [active]
718255004046	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
718255004047	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
718255004048	active site
718255004049	intersubunit interface [polypeptide binding]; other site
718255004050	catalytic residue [active]
718255004051	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
718255004052	Transcriptional regulator [Transcription]; Region: IclR; COG1414
718255004053	Bacterial transcriptional regulator; Region: IclR; pfam01614
718255004054	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
718255004055	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255004056	Walker A motif; other site
718255004057	ATP binding site [chemical binding]; other site
718255004058	Walker B motif; other site
718255004059	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
718255004060	Cache domain; Region: Cache_1; pfam02743
718255004061	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255004062	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255004063	dimer interface [polypeptide binding]; other site
718255004064	putative CheW interface [polypeptide binding]; other site
718255004065	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
718255004066	active site
718255004067	catalytic triad [active]
718255004068	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
718255004069	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718255004070	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718255004071	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718255004072	Walker A/P-loop; other site
718255004073	ATP binding site [chemical binding]; other site
718255004074	Q-loop/lid; other site
718255004075	ABC transporter signature motif; other site
718255004076	Walker B; other site
718255004077	D-loop; other site
718255004078	H-loop/switch region; other site
718255004079	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718255004080	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
718255004081	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718255004082	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
718255004083	FtsX-like permease family; Region: FtsX; pfam02687
718255004084	seryl-tRNA synthetase; Provisional; Region: PRK05431
718255004085	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
718255004086	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
718255004087	motif 1; other site
718255004088	dimer interface [polypeptide binding]; other site
718255004089	active site
718255004090	motif 2; other site
718255004091	motif 3; other site
718255004092	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
718255004093	active site
718255004094	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718255004095	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255004096	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
718255004097	V-type ATP synthase subunit I; Validated; Region: PRK05771
718255004098	ATP synthase subunit C; Region: ATP-synt_C; cl00466
718255004099	ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990
718255004100	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
718255004101	V-type ATP synthase subunit B; Provisional; Region: PRK04196
718255004102	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
718255004103	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
718255004104	Walker A motif homologous position; other site
718255004105	Walker B motif; other site
718255004106	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
718255004107	ATP synthase subunit D; Region: ATP-synt_D; pfam01813
718255004108	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
718255004109	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
718255004110	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
718255004111	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
718255004112	HD domain; Region: HD_3; pfam13023
718255004113	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
718255004114	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
718255004115	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
718255004116	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
718255004117	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
718255004118	active site
718255004119	substrate binding site [chemical binding]; other site
718255004120	cosubstrate binding site; other site
718255004121	catalytic site [active]
718255004122	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
718255004123	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
718255004124	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
718255004125	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
718255004126	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
718255004127	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
718255004128	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
718255004129	ligand binding site [chemical binding]; other site
718255004130	calcium binding site [ion binding]; other site
718255004131	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
718255004132	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
718255004133	Walker A/P-loop; other site
718255004134	ATP binding site [chemical binding]; other site
718255004135	Q-loop/lid; other site
718255004136	ABC transporter signature motif; other site
718255004137	Walker B; other site
718255004138	D-loop; other site
718255004139	H-loop/switch region; other site
718255004140	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
718255004141	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
718255004142	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718255004143	TM-ABC transporter signature motif; other site
718255004144	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
718255004145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255004146	active site
718255004147	phosphorylation site [posttranslational modification]
718255004148	intermolecular recognition site; other site
718255004149	dimerization interface [polypeptide binding]; other site
718255004150	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255004151	Cache domain; Region: Cache_1; pfam02743
718255004152	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255004153	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
718255004154	Histidine kinase; Region: His_kinase; pfam06580
718255004155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255004156	ATP binding site [chemical binding]; other site
718255004157	Mg2+ binding site [ion binding]; other site
718255004158	G-X-G motif; other site
718255004159	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
718255004160	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
718255004161	ligand binding site [chemical binding]; other site
718255004162	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
718255004163	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
718255004164	ligand binding site [chemical binding]; other site
718255004165	calcium binding site [ion binding]; other site
718255004166	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
718255004167	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
718255004168	glutaminase active site [active]
718255004169	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
718255004170	dimer interface [polypeptide binding]; other site
718255004171	active site
718255004172	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
718255004173	dimer interface [polypeptide binding]; other site
718255004174	active site
718255004175	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
718255004176	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
718255004177	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
718255004178	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
718255004179	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
718255004180	dimerization interface 3.5A [polypeptide binding]; other site
718255004181	active site
718255004182	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
718255004183	DHH family; Region: DHH; pfam01368
718255004184	DHHA1 domain; Region: DHHA1; pfam02272
718255004185	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255004186	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255004187	putative CheW interface [polypeptide binding]; other site
718255004188	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
718255004189	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
718255004190	Predicted secreted protein [Function unknown]; Region: COG4086
718255004191	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
718255004192	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
718255004193	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
718255004194	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
718255004195	active site
718255004196	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
718255004197	Predicted transcriptional regulators [Transcription]; Region: COG1695
718255004198	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
718255004199	Predicted membrane protein [Function unknown]; Region: COG4709
718255004200	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
718255004201	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
718255004202	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
718255004203	putative active site [active]
718255004204	putative metal binding site [ion binding]; other site
718255004205	CAAX protease self-immunity; Region: Abi; pfam02517
718255004206	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718255004207	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255004208	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255004209	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255004210	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
718255004211	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
718255004212	active site
718255004213	substrate binding site [chemical binding]; other site
718255004214	metal binding site [ion binding]; metal-binding site
718255004215	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
718255004216	Melibiase; Region: Melibiase; pfam02065
718255004217	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255004218	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255004219	DNA binding site [nucleotide binding]
718255004220	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718255004221	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255004222	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718255004223	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255004224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255004225	dimer interface [polypeptide binding]; other site
718255004226	conserved gate region; other site
718255004227	putative PBP binding loops; other site
718255004228	ABC-ATPase subunit interface; other site
718255004229	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255004230	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255004231	dimer interface [polypeptide binding]; other site
718255004232	conserved gate region; other site
718255004233	putative PBP binding loops; other site
718255004234	ABC-ATPase subunit interface; other site
718255004235	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
718255004236	putative active cleft [active]
718255004237	dimerization interface [polypeptide binding]; other site
718255004238	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
718255004239	active site
718255004240	Domain of unknown function (DUF377); Region: DUF377; pfam04041
718255004241	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
718255004242	active site
718255004243	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
718255004244	active site
718255004245	catalytic triad [active]
718255004246	oxyanion hole [active]
718255004247	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
718255004248	active site
718255004249	catalytic triad [active]
718255004250	oxyanion hole [active]
718255004251	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
718255004252	beta-galactosidase; Region: BGL; TIGR03356
718255004253	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
718255004254	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
718255004255	AAA domain; Region: AAA_14; pfam13173
718255004256	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
718255004257	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
718255004258	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
718255004259	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
718255004260	homodimer interface [polypeptide binding]; other site
718255004261	NADP binding site [chemical binding]; other site
718255004262	substrate binding site [chemical binding]; other site
718255004263	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
718255004264	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
718255004265	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
718255004266	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
718255004267	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255004268	Zn2+ binding site [ion binding]; other site
718255004269	Mg2+ binding site [ion binding]; other site
718255004270	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
718255004271	Mg binding site [ion binding]; other site
718255004272	nucleotide binding site [chemical binding]; other site
718255004273	putative protofilament interface [polypeptide binding]; other site
718255004274	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
718255004275	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
718255004276	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
718255004277	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
718255004278	integrase; Provisional; Region: int; PHA02601
718255004279	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255004280	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
718255004281	Int/Topo IB signature motif; other site
718255004282	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255004283	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255004284	non-specific DNA binding site [nucleotide binding]; other site
718255004285	salt bridge; other site
718255004286	sequence-specific DNA binding site [nucleotide binding]; other site
718255004287	Helix-turn-helix domain; Region: HTH_17; cl17695
718255004288	MobA/MobL family; Region: MobA_MobL; pfam03389
718255004289	Domain of unknown function, E. rectale Gene description (DUF3879); Region: DUF3879; pfam12995
718255004290	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
718255004291	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
718255004292	Transposase; Region: HTH_Tnp_1; cl17663
718255004293	putative transposase OrfB; Reviewed; Region: PHA02517
718255004294	Integrase core domain; Region: rve; pfam00665
718255004295	Integrase core domain; Region: rve_2; pfam13333
718255004296	DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207
718255004297	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718255004298	NlpC/P60 family; Region: NLPC_P60; cl17555
718255004299	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
718255004300	AAA-like domain; Region: AAA_10; pfam12846
718255004301	Domain of unknown function DUF87; Region: DUF87; pfam01935
718255004302	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
718255004303	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
718255004304	PrgI family protein; Region: PrgI; pfam12666
718255004305	Domain of unknown function (DUF4313); Region: DUF4313; pfam14190
718255004306	Domain of unknown function, E. rectale Gene description (DUF3879); Region: DUF3879; pfam12995
718255004307	MFS/sugar transport protein; Region: MFS_2; pfam13347
718255004308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718255004309	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255004310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255004311	active site
718255004312	phosphorylation site [posttranslational modification]
718255004313	intermolecular recognition site; other site
718255004314	dimerization interface [polypeptide binding]; other site
718255004315	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255004316	DNA binding site [nucleotide binding]
718255004317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255004318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255004319	dimer interface [polypeptide binding]; other site
718255004320	phosphorylation site [posttranslational modification]
718255004321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255004322	ATP binding site [chemical binding]; other site
718255004323	Mg2+ binding site [ion binding]; other site
718255004324	G-X-G motif; other site
718255004325	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718255004326	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718255004327	Walker A/P-loop; other site
718255004328	ATP binding site [chemical binding]; other site
718255004329	Q-loop/lid; other site
718255004330	ABC transporter signature motif; other site
718255004331	Walker B; other site
718255004332	D-loop; other site
718255004333	H-loop/switch region; other site
718255004334	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718255004335	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
718255004336	FtsX-like permease family; Region: FtsX; pfam02687
718255004337	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718255004338	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
718255004339	FtsX-like permease family; Region: FtsX; pfam02687
718255004340	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
718255004341	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255004342	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255004343	metal binding site [ion binding]; metal-binding site
718255004344	active site
718255004345	I-site; other site
718255004346	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
718255004347	PAS fold; Region: PAS_3; pfam08447
718255004348	putative active site [active]
718255004349	heme pocket [chemical binding]; other site
718255004350	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234
718255004351	active site
718255004352	catalytic residues [active]
718255004353	metal binding site [ion binding]; metal-binding site
718255004354	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255004355	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255004356	DNA binding site [nucleotide binding]
718255004357	domain linker motif; other site
718255004358	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718255004359	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718255004360	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255004361	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
718255004362	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
718255004363	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
718255004364	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255004365	Walker A/P-loop; other site
718255004366	ATP binding site [chemical binding]; other site
718255004367	Q-loop/lid; other site
718255004368	ABC transporter signature motif; other site
718255004369	Walker B; other site
718255004370	D-loop; other site
718255004371	H-loop/switch region; other site
718255004372	TOBE domain; Region: TOBE_2; pfam08402
718255004373	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
718255004374	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255004375	dimer interface [polypeptide binding]; other site
718255004376	conserved gate region; other site
718255004377	putative PBP binding loops; other site
718255004378	ABC-ATPase subunit interface; other site
718255004379	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255004380	dimer interface [polypeptide binding]; other site
718255004381	conserved gate region; other site
718255004382	putative PBP binding loops; other site
718255004383	ABC-ATPase subunit interface; other site
718255004384	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
718255004385	putative active site [active]
718255004386	catalytic site [active]
718255004387	putative metal binding site [ion binding]; other site
718255004388	oligomer interface [polypeptide binding]; other site
718255004389	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
718255004390	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
718255004391	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
718255004392	MgtC family; Region: MgtC; pfam02308
718255004393	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
718255004394	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
718255004395	active site
718255004396	catalytic site [active]
718255004397	metal binding site [ion binding]; metal-binding site
718255004398	dimer interface [polypeptide binding]; other site
718255004399	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
718255004400	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255004401	non-specific DNA binding site [nucleotide binding]; other site
718255004402	salt bridge; other site
718255004403	sequence-specific DNA binding site [nucleotide binding]; other site
718255004404	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234
718255004405	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255004406	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255004407	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255004408	Walker A/P-loop; other site
718255004409	ATP binding site [chemical binding]; other site
718255004410	Q-loop/lid; other site
718255004411	ABC transporter signature motif; other site
718255004412	Walker B; other site
718255004413	D-loop; other site
718255004414	H-loop/switch region; other site
718255004415	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255004416	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255004417	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255004418	Walker A/P-loop; other site
718255004419	ATP binding site [chemical binding]; other site
718255004420	Q-loop/lid; other site
718255004421	ABC transporter signature motif; other site
718255004422	Walker B; other site
718255004423	D-loop; other site
718255004424	H-loop/switch region; other site
718255004425	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255004426	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718255004427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255004428	dimer interface [polypeptide binding]; other site
718255004429	conserved gate region; other site
718255004430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
718255004431	ABC-ATPase subunit interface; other site
718255004432	Response regulator receiver domain; Region: Response_reg; pfam00072
718255004433	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255004434	active site
718255004435	phosphorylation site [posttranslational modification]
718255004436	intermolecular recognition site; other site
718255004437	dimerization interface [polypeptide binding]; other site
718255004438	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718255004439	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
718255004440	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255004441	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255004442	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
718255004443	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255004444	dimer interface [polypeptide binding]; other site
718255004445	phosphorylation site [posttranslational modification]
718255004446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255004447	ATP binding site [chemical binding]; other site
718255004448	Mg2+ binding site [ion binding]; other site
718255004449	G-X-G motif; other site
718255004450	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255004451	Response regulator receiver domain; Region: Response_reg; pfam00072
718255004452	active site
718255004453	phosphorylation site [posttranslational modification]
718255004454	intermolecular recognition site; other site
718255004455	dimerization interface [polypeptide binding]; other site
718255004456	Hpt domain; Region: Hpt; pfam01627
718255004457	Sulfatase; Region: Sulfatase; pfam00884
718255004458	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
718255004459	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718255004460	active site
718255004461	catalytic tetrad [active]
718255004462	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
718255004463	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
718255004464	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255004465	motif II; other site
718255004466	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
718255004467	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
718255004468	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
718255004469	Ligand Binding Site [chemical binding]; other site
718255004470	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
718255004471	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
718255004472	putative ATP binding site [chemical binding]; other site
718255004473	putative substrate interface [chemical binding]; other site
718255004474	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
718255004475	peptide binding site [polypeptide binding]; other site
718255004476	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
718255004477	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
718255004478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255004479	dimer interface [polypeptide binding]; other site
718255004480	conserved gate region; other site
718255004481	putative PBP binding loops; other site
718255004482	ABC-ATPase subunit interface; other site
718255004483	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
718255004484	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718255004485	Walker A/P-loop; other site
718255004486	ATP binding site [chemical binding]; other site
718255004487	Q-loop/lid; other site
718255004488	ABC transporter signature motif; other site
718255004489	Walker B; other site
718255004490	D-loop; other site
718255004491	H-loop/switch region; other site
718255004492	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718255004493	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
718255004494	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718255004495	Walker A/P-loop; other site
718255004496	ATP binding site [chemical binding]; other site
718255004497	Q-loop/lid; other site
718255004498	ABC transporter signature motif; other site
718255004499	Walker B; other site
718255004500	D-loop; other site
718255004501	H-loop/switch region; other site
718255004502	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718255004503	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255004504	dimerization interface [polypeptide binding]; other site
718255004505	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255004506	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255004507	dimer interface [polypeptide binding]; other site
718255004508	putative CheW interface [polypeptide binding]; other site
718255004509	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
718255004510	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
718255004511	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
718255004512	Na2 binding site [ion binding]; other site
718255004513	putative substrate binding site 1 [chemical binding]; other site
718255004514	Na binding site 1 [ion binding]; other site
718255004515	putative substrate binding site 2 [chemical binding]; other site
718255004516	Domain of unknown function (DUF4317); Region: DUF4317; pfam14199
718255004517	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255004518	Zn2+ binding site [ion binding]; other site
718255004519	Mg2+ binding site [ion binding]; other site
718255004520	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
718255004521	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255004522	Zn2+ binding site [ion binding]; other site
718255004523	Mg2+ binding site [ion binding]; other site
718255004524	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
718255004525	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
718255004526	HAMP domain; Region: HAMP; pfam00672
718255004527	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255004528	dimer interface [polypeptide binding]; other site
718255004529	putative CheW interface [polypeptide binding]; other site
718255004530	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
718255004531	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
718255004532	active site
718255004533	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
718255004534	active site
718255004535	N-terminal domain interface [polypeptide binding]; other site
718255004536	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760
718255004537	heme-binding site [chemical binding]; other site
718255004538	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
718255004539	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
718255004540	intersubunit interface [polypeptide binding]; other site
718255004541	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
718255004542	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
718255004543	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718255004544	ABC-ATPase subunit  interface; other site
718255004545	dimer interface [polypeptide binding]; other site
718255004546	putative PBP binding regions; other site
718255004547	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
718255004548	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
718255004549	Walker A/P-loop; other site
718255004550	ATP binding site [chemical binding]; other site
718255004551	Q-loop/lid; other site
718255004552	ABC transporter signature motif; other site
718255004553	Walker B; other site
718255004554	D-loop; other site
718255004555	H-loop/switch region; other site
718255004556	Part of AAA domain; Region: AAA_19; pfam13245
718255004557	AAA domain; Region: AAA_11; pfam13086
718255004558	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
718255004559	AAA domain; Region: AAA_12; pfam13087
718255004560	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
718255004561	Transcriptional regulators [Transcription]; Region: FadR; COG2186
718255004562	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718255004563	DNA-binding site [nucleotide binding]; DNA binding site
718255004564	FCD domain; Region: FCD; pfam07729
718255004565	fructuronate transporter; Provisional; Region: PRK10034; cl15264
718255004566	GntP family permease; Region: GntP_permease; pfam02447
718255004567	Dehydratase family; Region: ILVD_EDD; pfam00920
718255004568	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255004569	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255004570	non-specific DNA binding site [nucleotide binding]; other site
718255004571	salt bridge; other site
718255004572	sequence-specific DNA binding site [nucleotide binding]; other site
718255004573	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
718255004574	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718255004575	nucleotide binding site [chemical binding]; other site
718255004576	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
718255004577	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
718255004578	active site
718255004579	trimer interface [polypeptide binding]; other site
718255004580	allosteric site; other site
718255004581	active site lid [active]
718255004582	hexamer (dimer of trimers) interface [polypeptide binding]; other site
718255004583	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
718255004584	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
718255004585	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
718255004586	active site
718255004587	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095
718255004588	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
718255004589	active site
718255004590	dimer interface [polypeptide binding]; other site
718255004591	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
718255004592	dimer interface [polypeptide binding]; other site
718255004593	active site
718255004594	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
718255004595	MraW methylase family; Region: Methyltransf_5; cl17771
718255004596	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
718255004597	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
718255004598	active site
718255004599	multimer interface [polypeptide binding]; other site
718255004600	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
718255004601	predicted active site [active]
718255004602	catalytic triad [active]
718255004603	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255004604	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
718255004605	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
718255004606	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
718255004607	active site
718255004608	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255004609	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255004610	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
718255004611	putative dimerization interface [polypeptide binding]; other site
718255004612	Predicted membrane protein [Function unknown]; Region: COG2364
718255004613	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
718255004614	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
718255004615	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
718255004616	PA/protease or protease-like domain interface [polypeptide binding]; other site
718255004617	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
718255004618	Peptidase family M28; Region: Peptidase_M28; pfam04389
718255004619	metal binding site [ion binding]; metal-binding site
718255004620	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
718255004621	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255004622	Coenzyme A binding pocket [chemical binding]; other site
718255004623	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
718255004624	FlgN protein; Region: FlgN; pfam05130
718255004625	Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256
718255004626	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
718255004627	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
718255004628	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665
718255004629	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
718255004630	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
718255004631	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
718255004632	Global regulator protein family; Region: CsrA; pfam02599
718255004633	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
718255004634	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
718255004635	Flagellar protein FliS; Region: FliS; cl00654
718255004636	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4306
718255004637	flagellin; Provisional; Region: PRK12804
718255004638	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
718255004639	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
718255004640	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
718255004641	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
718255004642	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
718255004643	NeuB family; Region: NeuB; pfam03102
718255004644	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
718255004645	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
718255004646	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
718255004647	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
718255004648	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
718255004649	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
718255004650	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
718255004651	LicD family; Region: LicD; pfam04991
718255004652	Sulfatase; Region: Sulfatase; cl17466
718255004653	LicD family; Region: LicD; pfam04991
718255004654	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
718255004655	ligand binding site; other site
718255004656	tetramer interface; other site
718255004657	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
718255004658	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255004659	active site
718255004660	motif I; other site
718255004661	motif II; other site
718255004662	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
718255004663	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
718255004664	active site
718255004665	metal binding site [ion binding]; metal-binding site
718255004666	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718255004667	active site
718255004668	HIGH motif; other site
718255004669	nucleotide binding site [chemical binding]; other site
718255004670	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
718255004671	tetramer interface [polypeptide binding]; other site
718255004672	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
718255004673	active site
718255004674	Mg2+/Mn2+ binding site [ion binding]; other site
718255004675	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718255004676	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
718255004677	NAD(P) binding site [chemical binding]; other site
718255004678	active site
718255004679	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718255004680	active site
718255004681	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
718255004682	LicD family; Region: LicD; pfam04991
718255004683	Methyltransferase domain; Region: Methyltransf_23; pfam13489
718255004684	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255004685	S-adenosylmethionine binding site [chemical binding]; other site
718255004686	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
718255004687	LicD family; Region: LicD; cl01378
718255004688	LicD family; Region: LicD; pfam04991
718255004689	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
718255004690	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
718255004691	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
718255004692	active site
718255004693	metal-binding site
718255004694	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
718255004695	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718255004696	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255004697	homodimer interface [polypeptide binding]; other site
718255004698	catalytic residue [active]
718255004699	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
718255004700	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
718255004701	active site
718255004702	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
718255004703	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
718255004704	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
718255004705	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
718255004706	putative metal binding site; other site
718255004707	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
718255004708	TPR motif; other site
718255004709	binding surface
718255004710	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
718255004711	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
718255004712	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
718255004713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
718255004714	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
718255004715	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
718255004716	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
718255004717	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
718255004718	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
718255004719	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
718255004720	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
718255004721	putative homodimer interface [polypeptide binding]; other site
718255004722	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
718255004723	heterodimer interface [polypeptide binding]; other site
718255004724	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
718255004725	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
718255004726	23S rRNA interface [nucleotide binding]; other site
718255004727	L7/L12 interface [polypeptide binding]; other site
718255004728	putative thiostrepton binding site; other site
718255004729	L25 interface [polypeptide binding]; other site
718255004730	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
718255004731	mRNA/rRNA interface [nucleotide binding]; other site
718255004732	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
718255004733	core dimer interface [polypeptide binding]; other site
718255004734	peripheral dimer interface [polypeptide binding]; other site
718255004735	L10 interface [polypeptide binding]; other site
718255004736	L11 interface [polypeptide binding]; other site
718255004737	putative EF-Tu interaction site [polypeptide binding]; other site
718255004738	putative EF-G interaction site [polypeptide binding]; other site
718255004739	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
718255004740	Flavoprotein; Region: Flavoprotein; pfam02441
718255004741	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
718255004742	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
718255004743	ligand binding site [chemical binding]; other site
718255004744	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
718255004745	active site residue [active]
718255004746	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
718255004747	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
718255004748	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
718255004749	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
718255004750	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
718255004751	active site
718255004752	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
718255004753	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
718255004754	active site
718255004755	metal binding site [ion binding]; metal-binding site
718255004756	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
718255004757	active site
718255004758	dimerization interface [polypeptide binding]; other site
718255004759	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
718255004760	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
718255004761	active site
718255004762	metal binding site [ion binding]; metal-binding site
718255004763	homotetramer interface [polypeptide binding]; other site
718255004764	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
718255004765	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310
718255004766	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
718255004767	PDGLE domain; Region: PDGLE; pfam13190
718255004768	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
718255004769	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
718255004770	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
718255004771	Walker A/P-loop; other site
718255004772	ATP binding site [chemical binding]; other site
718255004773	Q-loop/lid; other site
718255004774	ABC transporter signature motif; other site
718255004775	Walker B; other site
718255004776	D-loop; other site
718255004777	H-loop/switch region; other site
718255004778	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
718255004779	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255004780	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255004781	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255004782	dimer interface [polypeptide binding]; other site
718255004783	putative CheW interface [polypeptide binding]; other site
718255004784	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255004785	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255004786	dimer interface [polypeptide binding]; other site
718255004787	putative CheW interface [polypeptide binding]; other site
718255004788	PilZ domain; Region: PilZ; pfam07238
718255004789	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
718255004790	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
718255004791	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
718255004792	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255004793	dimer interface [polypeptide binding]; other site
718255004794	conserved gate region; other site
718255004795	putative PBP binding loops; other site
718255004796	ABC-ATPase subunit interface; other site
718255004797	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
718255004798	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
718255004799	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
718255004800	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
718255004801	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
718255004802	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255004803	dimer interface [polypeptide binding]; other site
718255004804	conserved gate region; other site
718255004805	putative PBP binding loops; other site
718255004806	ABC-ATPase subunit interface; other site
718255004807	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
718255004808	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718255004809	Walker A/P-loop; other site
718255004810	ATP binding site [chemical binding]; other site
718255004811	Q-loop/lid; other site
718255004812	ABC transporter signature motif; other site
718255004813	Walker B; other site
718255004814	D-loop; other site
718255004815	H-loop/switch region; other site
718255004816	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
718255004817	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255004818	Walker A/P-loop; other site
718255004819	ATP binding site [chemical binding]; other site
718255004820	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718255004821	Q-loop/lid; other site
718255004822	ABC transporter signature motif; other site
718255004823	Walker B; other site
718255004824	D-loop; other site
718255004825	H-loop/switch region; other site
718255004826	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
718255004827	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
718255004828	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
718255004829	putative ligand binding site [chemical binding]; other site
718255004830	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718255004831	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
718255004832	TM-ABC transporter signature motif; other site
718255004833	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
718255004834	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
718255004835	TM-ABC transporter signature motif; other site
718255004836	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
718255004837	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
718255004838	Walker A/P-loop; other site
718255004839	ATP binding site [chemical binding]; other site
718255004840	Q-loop/lid; other site
718255004841	ABC transporter signature motif; other site
718255004842	Walker B; other site
718255004843	D-loop; other site
718255004844	H-loop/switch region; other site
718255004845	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
718255004846	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
718255004847	Walker A/P-loop; other site
718255004848	ATP binding site [chemical binding]; other site
718255004849	Q-loop/lid; other site
718255004850	ABC transporter signature motif; other site
718255004851	Walker B; other site
718255004852	D-loop; other site
718255004853	H-loop/switch region; other site
718255004854	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
718255004855	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
718255004856	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718255004857	active site
718255004858	catalytic tetrad [active]
718255004859	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718255004860	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
718255004861	TrkA-N domain; Region: TrkA_N; pfam02254
718255004862	TrkA-C domain; Region: TrkA_C; pfam02080
718255004863	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
718255004864	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
718255004865	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
718255004866	Methyltransferase domain; Region: Methyltransf_32; pfam13679
718255004867	Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761
718255004868	putative active site [active]
718255004869	putative metal binding residues [ion binding]; other site
718255004870	signature motif; other site
718255004871	putative dimer interface [polypeptide binding]; other site
718255004872	putative phosphate binding site [ion binding]; other site
718255004873	DJ-1 family protein; Region: not_thiJ; TIGR01383
718255004874	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
718255004875	conserved cys residue [active]
718255004876	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
718255004877	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
718255004878	Predicted membrane protein [Function unknown]; Region: COG2246
718255004879	GtrA-like protein; Region: GtrA; pfam04138
718255004880	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
718255004881	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
718255004882	Ligand binding site; other site
718255004883	Putative Catalytic site; other site
718255004884	DXD motif; other site
718255004885	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
718255004886	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
718255004887	Ligand binding site; other site
718255004888	Putative Catalytic site; other site
718255004889	DXD motif; other site
718255004890	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
718255004891	Fn3 associated; Region: Fn3_assoc; pfam13287
718255004892	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
718255004893	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
718255004894	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
718255004895	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
718255004896	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
718255004897	Acyltransferase family; Region: Acyl_transf_3; pfam01757
718255004898	Acyltransferase family; Region: Acyl_transf_3; pfam01757
718255004899	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
718255004900	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
718255004901	Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531
718255004902	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
718255004903	GDP-Fucose binding site [chemical binding]; other site
718255004904	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255004905	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
718255004906	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255004907	Walker A/P-loop; other site
718255004908	ATP binding site [chemical binding]; other site
718255004909	Q-loop/lid; other site
718255004910	ABC transporter signature motif; other site
718255004911	Walker B; other site
718255004912	D-loop; other site
718255004913	H-loop/switch region; other site
718255004914	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
718255004915	GDP-fucose protein O-fucosyltransferase; Region: O-FucT; pfam10250
718255004916	GDP-Fucose binding site [chemical binding]; other site
718255004917	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
718255004918	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
718255004919	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
718255004920	active site
718255004921	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
718255004922	dimer interface [polypeptide binding]; other site
718255004923	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
718255004924	Ligand Binding Site [chemical binding]; other site
718255004925	Molecular Tunnel; other site
718255004926	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255004927	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255004928	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255004929	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
718255004930	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
718255004931	NADP-binding site; other site
718255004932	homotetramer interface [polypeptide binding]; other site
718255004933	substrate binding site [chemical binding]; other site
718255004934	homodimer interface [polypeptide binding]; other site
718255004935	active site
718255004936	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
718255004937	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718255004938	active site
718255004939	Cupin domain; Region: Cupin_2; cl17218
718255004940	Penicillinase repressor; Region: Pencillinase_R; cl17580
718255004941	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
718255004942	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
718255004943	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
718255004944	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
718255004945	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
718255004946	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
718255004947	methyl coenzyme M reductase system, component A2; Region: met_CoM_red_A2; TIGR03269
718255004948	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
718255004949	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
718255004950	Probable Catalytic site; other site
718255004951	metal-binding site
718255004952	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
718255004953	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
718255004954	Probable Catalytic site; other site
718255004955	metal-binding site
718255004956	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
718255004957	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
718255004958	Probable Catalytic site; other site
718255004959	metal-binding site
718255004960	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
718255004961	Bacterial sugar transferase; Region: Bac_transf; pfam02397
718255004962	Transcriptional regulator [Transcription]; Region: LytR; COG1316
718255004963	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
718255004964	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
718255004965	active site
718255004966	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
718255004967	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
718255004968	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
718255004969	protein binding site [polypeptide binding]; other site
718255004970	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
718255004971	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718255004972	recombination factor protein RarA; Reviewed; Region: PRK13342
718255004973	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255004974	Walker A motif; other site
718255004975	ATP binding site [chemical binding]; other site
718255004976	Walker B motif; other site
718255004977	arginine finger; other site
718255004978	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
718255004979	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
718255004980	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
718255004981	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718255004982	catalytic residue [active]
718255004983	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
718255004984	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
718255004985	Transcriptional regulators [Transcription]; Region: GntR; COG1802
718255004986	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718255004987	DNA-binding site [nucleotide binding]; DNA binding site
718255004988	FCD domain; Region: FCD; pfam07729
718255004989	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
718255004990	Spore germination protein; Region: Spore_permease; cl17796
718255004991	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
718255004992	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
718255004993	Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353
718255004994	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
718255004995	active site
718255004996	catalytic site [active]
718255004997	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
718255004998	pyrroline-5-carboxylate reductase; Region: PLN02688
718255004999	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255005000	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
718255005001	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718255005002	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255005003	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255005004	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
718255005005	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
718255005006	substrate binding site [chemical binding]; other site
718255005007	oxyanion hole (OAH) forming residues; other site
718255005008	trimer interface [polypeptide binding]; other site
718255005009	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
718255005010	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
718255005011	minor groove reading motif; other site
718255005012	helix-hairpin-helix signature motif; other site
718255005013	substrate binding pocket [chemical binding]; other site
718255005014	active site
718255005015	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
718255005016	DNA binding and oxoG recognition site [nucleotide binding]
718255005017	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
718255005018	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
718255005019	active site
718255005020	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
718255005021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255005022	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
718255005023	Walker A/P-loop; other site
718255005024	ATP binding site [chemical binding]; other site
718255005025	Q-loop/lid; other site
718255005026	ABC transporter signature motif; other site
718255005027	Walker B; other site
718255005028	D-loop; other site
718255005029	H-loop/switch region; other site
718255005030	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
718255005031	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
718255005032	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
718255005033	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
718255005034	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
718255005035	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
718255005036	reactive center loop; other site
718255005037	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
718255005038	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
718255005039	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
718255005040	putative active site [active]
718255005041	putative metal binding site [ion binding]; other site
718255005042	Response regulator receiver domain; Region: Response_reg; pfam00072
718255005043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255005044	active site
718255005045	phosphorylation site [posttranslational modification]
718255005046	intermolecular recognition site; other site
718255005047	dimerization interface [polypeptide binding]; other site
718255005048	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255005049	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
718255005050	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
718255005051	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
718255005052	active site
718255005053	PAS fold; Region: PAS_3; pfam08447
718255005054	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255005055	metal binding site [ion binding]; metal-binding site
718255005056	active site
718255005057	I-site; other site
718255005058	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718255005059	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718255005060	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718255005061	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255005062	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255005063	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
718255005064	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
718255005065	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255005066	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255005067	Transcriptional regulator PadR-like family; Region: PadR; cl17335
718255005068	Predicted transcriptional regulators [Transcription]; Region: COG1695
718255005069	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
718255005070	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
718255005071	active site
718255005072	dimer interface [polypeptide binding]; other site
718255005073	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718255005074	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
718255005075	substrate binding site [chemical binding]; other site
718255005076	ATP binding site [chemical binding]; other site
718255005077	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718255005078	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
718255005079	substrate binding site [chemical binding]; other site
718255005080	ATP binding site [chemical binding]; other site
718255005081	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
718255005082	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255005083	active site
718255005084	DNA binding site [nucleotide binding]
718255005085	Int/Topo IB signature motif; other site
718255005086	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
718255005087	Domain of unknown function (DUF4317); Region: DUF4317; pfam14199
718255005088	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
718255005089	active site
718255005090	catalytic triad [active]
718255005091	oxyanion hole [active]
718255005092	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
718255005093	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
718255005094	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
718255005095	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718255005096	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255005097	DNA binding residues [nucleotide binding]
718255005098	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
718255005099	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255005100	Coenzyme A binding pocket [chemical binding]; other site
718255005101	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718255005102	binding surface
718255005103	TPR motif; other site
718255005104	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718255005105	TPR motif; other site
718255005106	binding surface
718255005107	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
718255005108	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
718255005109	HflX GTPase family; Region: HflX; cd01878
718255005110	G1 box; other site
718255005111	GTP/Mg2+ binding site [chemical binding]; other site
718255005112	Switch I region; other site
718255005113	G2 box; other site
718255005114	G3 box; other site
718255005115	Switch II region; other site
718255005116	G4 box; other site
718255005117	G5 box; other site
718255005118	dihydroorotase; Validated; Region: pyrC; PRK09357
718255005119	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
718255005120	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
718255005121	active site
718255005122	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
718255005123	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
718255005124	FAD binding pocket [chemical binding]; other site
718255005125	FAD binding motif [chemical binding]; other site
718255005126	phosphate binding motif [ion binding]; other site
718255005127	beta-alpha-beta structure motif; other site
718255005128	NAD binding pocket [chemical binding]; other site
718255005129	Iron coordination center [ion binding]; other site
718255005130	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
718255005131	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
718255005132	heterodimer interface [polypeptide binding]; other site
718255005133	active site
718255005134	FMN binding site [chemical binding]; other site
718255005135	homodimer interface [polypeptide binding]; other site
718255005136	substrate binding site [chemical binding]; other site
718255005137	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255005138	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
718255005139	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
718255005140	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
718255005141	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255005142	Zn2+ binding site [ion binding]; other site
718255005143	Mg2+ binding site [ion binding]; other site
718255005144	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
718255005145	synthetase active site [active]
718255005146	NTP binding site [chemical binding]; other site
718255005147	metal binding site [ion binding]; metal-binding site
718255005148	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
718255005149	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
718255005150	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
718255005151	coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994
718255005152	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255005153	FeS/SAM binding site; other site
718255005154	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255005155	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255005156	sequence-specific DNA binding site [nucleotide binding]; other site
718255005157	salt bridge; other site
718255005158	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718255005159	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718255005160	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255005161	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255005162	MFS/sugar transport protein; Region: MFS_2; pfam13347
718255005163	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
718255005164	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718255005165	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718255005166	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255005167	Helix-turn-helix domain; Region: HTH_18; pfam12833
718255005168	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255005169	histidyl-tRNA synthetase; Region: hisS; TIGR00442
718255005170	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
718255005171	dimer interface [polypeptide binding]; other site
718255005172	motif 1; other site
718255005173	active site
718255005174	motif 2; other site
718255005175	motif 3; other site
718255005176	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
718255005177	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
718255005178	dimer interface [polypeptide binding]; other site
718255005179	anticodon binding site; other site
718255005180	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
718255005181	homodimer interface [polypeptide binding]; other site
718255005182	motif 1; other site
718255005183	active site
718255005184	motif 2; other site
718255005185	GAD domain; Region: GAD; pfam02938
718255005186	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
718255005187	active site
718255005188	motif 3; other site
718255005189	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
718255005190	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
718255005191	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
718255005192	Cupin domain; Region: Cupin_2; cl17218
718255005193	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718255005194	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255005195	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718255005196	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718255005197	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718255005198	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255005199	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255005200	DNA binding site [nucleotide binding]
718255005201	domain linker motif; other site
718255005202	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
718255005203	dimerization interface [polypeptide binding]; other site
718255005204	ligand binding site [chemical binding]; other site
718255005205	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255005206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255005207	dimer interface [polypeptide binding]; other site
718255005208	ABC-ATPase subunit interface; other site
718255005209	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255005210	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
718255005211	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
718255005212	Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364
718255005213	Glycosyl hydrolase family 43; Region: GH43_4; cd08983
718255005214	active site
718255005215	beta-D-glucuronidase; Provisional; Region: PRK10150
718255005216	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718255005217	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718255005218	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718255005219	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255005220	sequence-specific DNA binding site [nucleotide binding]; other site
718255005221	salt bridge; other site
718255005222	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
718255005223	HsdM N-terminal domain; Region: HsdM_N; pfam12161
718255005224	Virulence protein [General function prediction only]; Region: COG3943
718255005225	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255005226	dimerization interface [polypeptide binding]; other site
718255005227	Histidine kinase; Region: His_kinase; pfam06580
718255005228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255005229	ATP binding site [chemical binding]; other site
718255005230	Mg2+ binding site [ion binding]; other site
718255005231	G-X-G motif; other site
718255005232	Response regulator receiver domain; Region: Response_reg; pfam00072
718255005233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255005234	active site
718255005235	phosphorylation site [posttranslational modification]
718255005236	intermolecular recognition site; other site
718255005237	dimerization interface [polypeptide binding]; other site
718255005238	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255005239	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255005240	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255005241	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255005242	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718255005243	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255005244	dimer interface [polypeptide binding]; other site
718255005245	conserved gate region; other site
718255005246	putative PBP binding loops; other site
718255005247	ABC-ATPase subunit interface; other site
718255005248	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255005249	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255005250	dimer interface [polypeptide binding]; other site
718255005251	conserved gate region; other site
718255005252	putative PBP binding loops; other site
718255005253	ABC-ATPase subunit interface; other site
718255005254	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
718255005255	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
718255005256	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
718255005257	alpha-galactosidase; Region: PLN02808; cl17638
718255005258	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
718255005259	dimerization interface [polypeptide binding]; other site
718255005260	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255005261	dimer interface [polypeptide binding]; other site
718255005262	phosphorylation site [posttranslational modification]
718255005263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255005264	ATP binding site [chemical binding]; other site
718255005265	Mg2+ binding site [ion binding]; other site
718255005266	G-X-G motif; other site
718255005267	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
718255005268	Response regulator receiver domain; Region: Response_reg; pfam00072
718255005269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255005270	active site
718255005271	phosphorylation site [posttranslational modification]
718255005272	intermolecular recognition site; other site
718255005273	dimerization interface [polypeptide binding]; other site
718255005274	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
718255005275	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
718255005276	putative active site [active]
718255005277	oxyanion strand; other site
718255005278	catalytic triad [active]
718255005279	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
718255005280	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
718255005281	substrate binding site [chemical binding]; other site
718255005282	glutamase interaction surface [polypeptide binding]; other site
718255005283	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
718255005284	ligand binding site [chemical binding]; other site
718255005285	active site
718255005286	UGI interface [polypeptide binding]; other site
718255005287	catalytic site [active]
718255005288	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
718255005289	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
718255005290	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
718255005291	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
718255005292	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
718255005293	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
718255005294	substrate binding pocket [chemical binding]; other site
718255005295	dimer interface [polypeptide binding]; other site
718255005296	inhibitor binding site; inhibition site
718255005297	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
718255005298	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
718255005299	B12 binding site [chemical binding]; other site
718255005300	cobalt ligand [ion binding]; other site
718255005301	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
718255005302	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
718255005303	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
718255005304	homotrimer interaction site [polypeptide binding]; other site
718255005305	zinc binding site [ion binding]; other site
718255005306	CDP-binding sites; other site
718255005307	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255005308	Interdomain contacts; other site
718255005309	Cytokine receptor motif; other site
718255005310	Response regulator receiver domain; Region: Response_reg; pfam00072
718255005311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255005312	active site
718255005313	phosphorylation site [posttranslational modification]
718255005314	intermolecular recognition site; other site
718255005315	dimerization interface [polypeptide binding]; other site
718255005316	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255005317	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255005318	metal binding site [ion binding]; metal-binding site
718255005319	active site
718255005320	I-site; other site
718255005321	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
718255005322	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
718255005323	trimer interface [polypeptide binding]; other site
718255005324	active site
718255005325	substrate binding site [chemical binding]; other site
718255005326	CoA binding site [chemical binding]; other site
718255005327	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
718255005328	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
718255005329	active site
718255005330	HIGH motif; other site
718255005331	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718255005332	active site
718255005333	KMSKS motif; other site
718255005334	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
718255005335	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
718255005336	active site
718255005337	metal binding site [ion binding]; metal-binding site
718255005338	dimerization interface [polypeptide binding]; other site
718255005339	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
718255005340	RNA polymerase factor sigma-70; Validated; Region: PRK08295
718255005341	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718255005342	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
718255005343	DNA binding residues [nucleotide binding]
718255005344	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
718255005345	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
718255005346	hypothetical protein; Provisional; Region: PHA03169
718255005347	Sulfatase; Region: Sulfatase; pfam00884
718255005348	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
718255005349	PA14 domain; Region: PA14; cl08459
718255005350	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
718255005351	active site
718255005352	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
718255005353	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
718255005354	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
718255005355	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
718255005356	active site
718255005357	DNA polymerase I; Provisional; Region: PRK05755
718255005358	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
718255005359	active site
718255005360	metal binding site 1 [ion binding]; metal-binding site
718255005361	putative 5' ssDNA interaction site; other site
718255005362	metal binding site 3; metal-binding site
718255005363	metal binding site 2 [ion binding]; metal-binding site
718255005364	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
718255005365	putative DNA binding site [nucleotide binding]; other site
718255005366	putative metal binding site [ion binding]; other site
718255005367	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
718255005368	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
718255005369	active site
718255005370	DNA binding site [nucleotide binding]
718255005371	catalytic site [active]
718255005372	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
718255005373	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
718255005374	CoA-binding site [chemical binding]; other site
718255005375	ATP-binding [chemical binding]; other site
718255005376	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
718255005377	Cell division protein FtsA; Region: FtsA; smart00842
718255005378	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
718255005379	nucleotide binding site [chemical binding]; other site
718255005380	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
718255005381	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
718255005382	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
718255005383	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
718255005384	IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330
718255005385	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
718255005386	AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138
718255005387	hypothetical protein; Provisional; Region: PRK13670
718255005388	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
718255005389	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
718255005390	propionate/acetate kinase; Provisional; Region: PRK12379
718255005391	Protein of unknown function, DUF624; Region: DUF624; pfam04854
718255005392	putative phosphate acyltransferase; Provisional; Region: PRK05331
718255005393	acyl carrier protein; Provisional; Region: acpP; PRK00982
718255005394	ribonuclease III; Reviewed; Region: rnc; PRK00102
718255005395	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
718255005396	dimerization interface [polypeptide binding]; other site
718255005397	active site
718255005398	metal binding site [ion binding]; metal-binding site
718255005399	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
718255005400	dsRNA binding site [nucleotide binding]; other site
718255005401	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
718255005402	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
718255005403	Walker A/P-loop; other site
718255005404	ATP binding site [chemical binding]; other site
718255005405	Q-loop/lid; other site
718255005406	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
718255005407	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
718255005408	ABC transporter signature motif; other site
718255005409	Walker B; other site
718255005410	D-loop; other site
718255005411	H-loop/switch region; other site
718255005412	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
718255005413	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
718255005414	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
718255005415	threonine dehydratase; Provisional; Region: PRK08198
718255005416	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
718255005417	tetramer interface [polypeptide binding]; other site
718255005418	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255005419	catalytic residue [active]
718255005420	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
718255005421	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
718255005422	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
718255005423	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
718255005424	GTP binding site [chemical binding]; other site
718255005425	Signal peptide binding domain; Region: SRP_SPB; pfam02978
718255005426	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
718255005427	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
718255005428	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
718255005429	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
718255005430	RimM N-terminal domain; Region: RimM; pfam01782
718255005431	PRC-barrel domain; Region: PRC; pfam05239
718255005432	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
718255005433	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
718255005434	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718255005435	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
718255005436	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
718255005437	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718255005438	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255005439	homodimer interface [polypeptide binding]; other site
718255005440	catalytic residue [active]
718255005441	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255005442	Zn2+ binding site [ion binding]; other site
718255005443	Mg2+ binding site [ion binding]; other site
718255005444	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
718255005445	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
718255005446	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
718255005447	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
718255005448	S-ribosylhomocysteinase; Provisional; Region: PRK02260
718255005449	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
718255005450	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
718255005451	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
718255005452	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718255005453	membrane-bound complex binding site; other site
718255005454	hinge residues; other site
718255005455	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718255005456	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
718255005457	substrate binding pocket [chemical binding]; other site
718255005458	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
718255005459	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255005460	dimer interface [polypeptide binding]; other site
718255005461	conserved gate region; other site
718255005462	putative PBP binding loops; other site
718255005463	ABC-ATPase subunit interface; other site
718255005464	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
718255005465	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
718255005466	Walker A/P-loop; other site
718255005467	ATP binding site [chemical binding]; other site
718255005468	Q-loop/lid; other site
718255005469	ABC transporter signature motif; other site
718255005470	Walker B; other site
718255005471	D-loop; other site
718255005472	H-loop/switch region; other site
718255005473	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
718255005474	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255005475	S-adenosylmethionine binding site [chemical binding]; other site
718255005476	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
718255005477	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
718255005478	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
718255005479	Ligand Binding Site [chemical binding]; other site
718255005480	PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381
718255005481	regulatory protein interface [polypeptide binding]; other site
718255005482	regulatory phosphorylation site [posttranslational modification]; other site
718255005483	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
718255005484	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
718255005485	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255005486	FeS/SAM binding site; other site
718255005487	hypothetical protein; Provisional; Region: PRK05473
718255005488	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
718255005489	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
718255005490	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
718255005491	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
718255005492	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
718255005493	Protein of unknown function (DUF964); Region: DUF964; pfam06133
718255005494	YceG-like family; Region: YceG; pfam02618
718255005495	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
718255005496	Peptidase family U32; Region: Peptidase_U32; pfam01136
718255005497	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
718255005498	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
718255005499	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
718255005500	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
718255005501	putative ligand binding site [chemical binding]; other site
718255005502	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718255005503	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
718255005504	TM-ABC transporter signature motif; other site
718255005505	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718255005506	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
718255005507	TM-ABC transporter signature motif; other site
718255005508	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255005509	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255005510	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718255005511	dimerization interface [polypeptide binding]; other site
718255005512	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
718255005513	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
718255005514	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
718255005515	GDP-binding site [chemical binding]; other site
718255005516	ACT binding site; other site
718255005517	IMP binding site; other site
718255005518	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
718255005519	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
718255005520	active site
718255005521	HIGH motif; other site
718255005522	dimer interface [polypeptide binding]; other site
718255005523	KMSKS motif; other site
718255005524	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
718255005525	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
718255005526	Catalytic site [active]
718255005527	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
718255005528	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
718255005529	GTP/Mg2+ binding site [chemical binding]; other site
718255005530	G4 box; other site
718255005531	G5 box; other site
718255005532	G1 box; other site
718255005533	Switch I region; other site
718255005534	G2 box; other site
718255005535	G3 box; other site
718255005536	Switch II region; other site
718255005537	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
718255005538	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
718255005539	Catalytic site [active]
718255005540	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
718255005541	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
718255005542	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
718255005543	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
718255005544	putative oligomer interface [polypeptide binding]; other site
718255005545	putative active site [active]
718255005546	metal binding site [ion binding]; metal-binding site
718255005547	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
718255005548	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
718255005549	Walker A/P-loop; other site
718255005550	ATP binding site [chemical binding]; other site
718255005551	Q-loop/lid; other site
718255005552	ABC transporter signature motif; other site
718255005553	Walker B; other site
718255005554	D-loop; other site
718255005555	H-loop/switch region; other site
718255005556	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
718255005557	GTP-binding protein Der; Reviewed; Region: PRK00093
718255005558	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
718255005559	G1 box; other site
718255005560	GTP/Mg2+ binding site [chemical binding]; other site
718255005561	Switch I region; other site
718255005562	G2 box; other site
718255005563	Switch II region; other site
718255005564	G3 box; other site
718255005565	G4 box; other site
718255005566	G5 box; other site
718255005567	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
718255005568	G1 box; other site
718255005569	GTP/Mg2+ binding site [chemical binding]; other site
718255005570	Switch I region; other site
718255005571	G2 box; other site
718255005572	G3 box; other site
718255005573	Switch II region; other site
718255005574	G4 box; other site
718255005575	G5 box; other site
718255005576	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
718255005577	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
718255005578	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
718255005579	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
718255005580	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
718255005581	trimer interface [polypeptide binding]; other site
718255005582	active site
718255005583	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
718255005584	classical (c) SDRs; Region: SDR_c; cd05233
718255005585	NAD(P) binding site [chemical binding]; other site
718255005586	active site
718255005587	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
718255005588	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
718255005589	Walker A/P-loop; other site
718255005590	ATP binding site [chemical binding]; other site
718255005591	Q-loop/lid; other site
718255005592	ABC transporter signature motif; other site
718255005593	Walker B; other site
718255005594	D-loop; other site
718255005595	H-loop/switch region; other site
718255005596	TOBE domain; Region: TOBE; pfam03459
718255005597	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
718255005598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255005599	ATP binding site [chemical binding]; other site
718255005600	Mg2+ binding site [ion binding]; other site
718255005601	G-X-G motif; other site
718255005602	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
718255005603	anchoring element; other site
718255005604	dimer interface [polypeptide binding]; other site
718255005605	ATP binding site [chemical binding]; other site
718255005606	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
718255005607	active site
718255005608	putative metal-binding site [ion binding]; other site
718255005609	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
718255005610	DNA gyrase subunit A; Validated; Region: PRK05560
718255005611	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
718255005612	CAP-like domain; other site
718255005613	active site
718255005614	primary dimer interface [polypeptide binding]; other site
718255005615	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718255005616	CAAX protease self-immunity; Region: Abi; pfam02517
718255005617	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
718255005618	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255005619	Coenzyme A binding pocket [chemical binding]; other site
718255005620	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
718255005621	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
718255005622	active site
718255005623	dimer interface [polypeptide binding]; other site
718255005624	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
718255005625	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
718255005626	active site
718255005627	FMN binding site [chemical binding]; other site
718255005628	substrate binding site [chemical binding]; other site
718255005629	3Fe-4S cluster binding site [ion binding]; other site
718255005630	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
718255005631	domain interface; other site
718255005632	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
718255005633	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
718255005634	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
718255005635	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
718255005636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255005637	active site
718255005638	phosphorylation site [posttranslational modification]
718255005639	intermolecular recognition site; other site
718255005640	dimerization interface [polypeptide binding]; other site
718255005641	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255005642	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255005643	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255005644	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255005645	dimerization interface [polypeptide binding]; other site
718255005646	Histidine kinase; Region: His_kinase; pfam06580
718255005647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255005648	ATP binding site [chemical binding]; other site
718255005649	Mg2+ binding site [ion binding]; other site
718255005650	G-X-G motif; other site
718255005651	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718255005652	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
718255005653	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
718255005654	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
718255005655	Walker A/P-loop; other site
718255005656	ATP binding site [chemical binding]; other site
718255005657	Q-loop/lid; other site
718255005658	ABC transporter signature motif; other site
718255005659	Walker B; other site
718255005660	D-loop; other site
718255005661	H-loop/switch region; other site
718255005662	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
718255005663	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718255005664	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
718255005665	TM-ABC transporter signature motif; other site
718255005666	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
718255005667	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
718255005668	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718255005669	TM-ABC transporter signature motif; other site
718255005670	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
718255005671	putative ligand binding site [chemical binding]; other site
718255005672	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
718255005673	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
718255005674	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
718255005675	active site
718255005676	Zn binding site [ion binding]; other site
718255005677	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
718255005678	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
718255005679	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
718255005680	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255005681	FeS/SAM binding site; other site
718255005682	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
718255005683	Malic enzyme, N-terminal domain; Region: malic; pfam00390
718255005684	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
718255005685	putative NAD(P) binding site [chemical binding]; other site
718255005686	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
718255005687	PLD-like domain; Region: PLDc_2; pfam13091
718255005688	putative homodimer interface [polypeptide binding]; other site
718255005689	putative active site [active]
718255005690	catalytic site [active]
718255005691	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
718255005692	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
718255005693	Mg binding site [ion binding]; other site
718255005694	nucleotide binding site [chemical binding]; other site
718255005695	putative protofilament interface [polypeptide binding]; other site
718255005696	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
718255005697	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
718255005698	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
718255005699	Helix-turn-helix domain; Region: HTH_17; cl17695
718255005700	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
718255005701	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718255005702	cofactor binding site; other site
718255005703	DNA binding site [nucleotide binding]
718255005704	substrate interaction site [chemical binding]; other site
718255005705	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
718255005706	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718255005707	cofactor binding site; other site
718255005708	DNA binding site [nucleotide binding]
718255005709	substrate interaction site [chemical binding]; other site
718255005710	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718255005711	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
718255005712	cofactor binding site; other site
718255005713	DNA binding site [nucleotide binding]
718255005714	substrate interaction site [chemical binding]; other site
718255005715	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
718255005716	Sel1-like repeats; Region: SEL1; smart00671
718255005717	Sel1-like repeats; Region: SEL1; smart00671
718255005718	Sel1-like repeats; Region: SEL1; smart00671
718255005719	Sel1-like repeats; Region: SEL1; smart00671
718255005720	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
718255005721	Sel1-like repeats; Region: SEL1; smart00671
718255005722	Sel1-like repeats; Region: SEL1; smart00671
718255005723	type III secretion system protein InvA; Provisional; Region: PRK15337
718255005724	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255005725	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
718255005726	ATP binding site [chemical binding]; other site
718255005727	Mg2+ binding site [ion binding]; other site
718255005728	G-X-G motif; other site
718255005729	Transposase domain (DUF772); Region: DUF772; pfam05598
718255005730	MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane...; Region: MATH; cl02446
718255005731	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
718255005732	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255005733	FeS/SAM binding site; other site
718255005734	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
718255005735	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255005736	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255005737	non-specific DNA binding site [nucleotide binding]; other site
718255005738	salt bridge; other site
718255005739	sequence-specific DNA binding site [nucleotide binding]; other site
718255005740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255005741	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
718255005742	Walker A motif; other site
718255005743	ATP binding site [chemical binding]; other site
718255005744	Walker B motif; other site
718255005745	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
718255005746	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
718255005747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255005748	active site
718255005749	phosphorylation site [posttranslational modification]
718255005750	intermolecular recognition site; other site
718255005751	dimerization interface [polypeptide binding]; other site
718255005752	LytTr DNA-binding domain; Region: LytTR; pfam04397
718255005753	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
718255005754	ATP binding site [chemical binding]; other site
718255005755	Mg2+ binding site [ion binding]; other site
718255005756	G-X-G motif; other site
718255005757	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
718255005758	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
718255005759	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
718255005760	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
718255005761	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718255005762	substrate interaction site [chemical binding]; other site
718255005763	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718255005764	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
718255005765	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718255005766	cofactor binding site; other site
718255005767	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
718255005768	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255005769	active site
718255005770	phosphorylation site [posttranslational modification]
718255005771	intermolecular recognition site; other site
718255005772	dimerization interface [polypeptide binding]; other site
718255005773	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718255005774	DNA binding residues [nucleotide binding]
718255005775	dimerization interface [polypeptide binding]; other site
718255005776	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
718255005777	Histidine kinase; Region: HisKA_3; pfam07730
718255005778	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255005779	ATP binding site [chemical binding]; other site
718255005780	Mg2+ binding site [ion binding]; other site
718255005781	G-X-G motif; other site
718255005782	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
718255005783	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255005784	S-adenosylmethionine binding site [chemical binding]; other site
718255005785	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
718255005786	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
718255005787	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
718255005788	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
718255005789	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
718255005790	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
718255005791	trmE is a tRNA modification GTPase; Region: trmE; cd04164
718255005792	G1 box; other site
718255005793	GTP/Mg2+ binding site [chemical binding]; other site
718255005794	Switch I region; other site
718255005795	G2 box; other site
718255005796	Switch II region; other site
718255005797	G3 box; other site
718255005798	G4 box; other site
718255005799	G5 box; other site
718255005800	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
718255005801	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
718255005802	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
718255005803	G-X-X-G motif; other site
718255005804	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
718255005805	RxxxH motif; other site
718255005806	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
718255005807	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
718255005808	ribonuclease P; Reviewed; Region: rnpA; PRK00499
718255005809	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
718255005810	DnaA N-terminal domain; Region: DnaA_N; pfam11638
718255005811	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
718255005812	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255005813	Walker A motif; other site
718255005814	ATP binding site [chemical binding]; other site
718255005815	Walker B motif; other site
718255005816	arginine finger; other site
718255005817	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
718255005818	DnaA box-binding interface [nucleotide binding]; other site
718255005819	DNA polymerase III subunit beta; Validated; Region: PRK05643
718255005820	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
718255005821	putative DNA binding surface [nucleotide binding]; other site
718255005822	dimer interface [polypeptide binding]; other site
718255005823	beta-clamp/clamp loader binding surface; other site
718255005824	beta-clamp/translesion DNA polymerase binding surface; other site
718255005825	S4 domain; Region: S4_2; pfam13275
718255005826	recombination protein F; Reviewed; Region: recF; PRK00064
718255005827	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
718255005828	Walker A/P-loop; other site
718255005829	ATP binding site [chemical binding]; other site
718255005830	Q-loop/lid; other site
718255005831	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255005832	ABC transporter signature motif; other site
718255005833	Walker B; other site
718255005834	D-loop; other site
718255005835	H-loop/switch region; other site
718255005836	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
718255005837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255005838	Mg2+ binding site [ion binding]; other site
718255005839	G-X-G motif; other site
718255005840	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
718255005841	anchoring element; other site
718255005842	dimer interface [polypeptide binding]; other site
718255005843	ATP binding site [chemical binding]; other site
718255005844	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
718255005845	active site
718255005846	putative metal-binding site [ion binding]; other site
718255005847	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
718255005848	DNA gyrase subunit A; Validated; Region: PRK05560
718255005849	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
718255005850	CAP-like domain; other site
718255005851	active site
718255005852	primary dimer interface [polypeptide binding]; other site
718255005853	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718255005854	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718255005855	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718255005856	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718255005857	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718255005858	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718255005859	HipA-like C-terminal domain; Region: HipA_C; pfam07804
718255005860	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255005861	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
718255005862	Walker A/P-loop; other site
718255005863	ATP binding site [chemical binding]; other site
718255005864	Q-loop/lid; other site
718255005865	ABC transporter signature motif; other site
718255005866	Walker B; other site
718255005867	D-loop; other site
718255005868	H-loop/switch region; other site
718255005869	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
718255005870	LytTr DNA-binding domain; Region: LytTR; smart00850
718255005871	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
718255005872	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255005873	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
718255005874	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255005875	Uncharacterized conserved protein [Function unknown]; Region: COG5495
718255005876	Rossmann-like domain; Region: Rossmann-like; pfam10727
718255005877	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
718255005878	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
718255005879	oligomerization interface [polypeptide binding]; other site
718255005880	active site
718255005881	metal binding site [ion binding]; metal-binding site
718255005882	pantoate--beta-alanine ligase; Region: panC; TIGR00018
718255005883	Pantoate-beta-alanine ligase; Region: PanC; cd00560
718255005884	active site
718255005885	ATP-binding site [chemical binding]; other site
718255005886	pantoate-binding site; other site
718255005887	HXXH motif; other site
718255005888	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
718255005889	tetramerization interface [polypeptide binding]; other site
718255005890	active site
718255005891	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
718255005892	CsbD-like; Region: CsbD; cl17424
718255005893	fumarate hydratase; Provisional; Region: PRK06246
718255005894	Fumarase C-terminus; Region: Fumerase_C; cl00795
718255005895	AAA ATPase domain; Region: AAA_16; pfam13191
718255005896	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
718255005897	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
718255005898	active site
718255005899	ATP binding site [chemical binding]; other site
718255005900	substrate binding site [chemical binding]; other site
718255005901	activation loop (A-loop); other site
718255005902	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
718255005903	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255005904	active site
718255005905	Int/Topo IB signature motif; other site
718255005906	DNA binding site [nucleotide binding]
718255005907	D5 N terminal like; Region: D5_N; cl07360
718255005908	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
718255005909	multiple promoter invertase; Provisional; Region: mpi; PRK13413
718255005910	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255005911	catalytic residues [active]
718255005912	catalytic nucleophile [active]
718255005913	Mor transcription activator family; Region: Mor; cl02360
718255005914	Helix-turn-helix domain; Region: HTH_17; pfam12728
718255005915	ammonium transporter; Region: amt; TIGR00836
718255005916	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
718255005917	Nitrogen regulatory protein P-II; Region: P-II; smart00938
718255005918	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
718255005919	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
718255005920	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
718255005921	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
718255005922	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
718255005923	intersubunit interface [polypeptide binding]; other site
718255005924	active site
718255005925	zinc binding site [ion binding]; other site
718255005926	Na+ binding site [ion binding]; other site
718255005927	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
718255005928	putative lipid kinase; Reviewed; Region: PRK13337
718255005929	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718255005930	dimerization domain swap beta strand [polypeptide binding]; other site
718255005931	regulatory protein interface [polypeptide binding]; other site
718255005932	active site
718255005933	regulatory phosphorylation site [posttranslational modification]; other site
718255005934	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
718255005935	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
718255005936	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
718255005937	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
718255005938	FAD binding domain; Region: FAD_binding_4; pfam01565
718255005939	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
718255005940	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
718255005941	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
718255005942	oligomer interface [polypeptide binding]; other site
718255005943	putative active site [active]
718255005944	metal binding site [ion binding]; metal-binding site
718255005945	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
718255005946	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
718255005947	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
718255005948	Hpr binding site; other site
718255005949	active site
718255005950	homohexamer subunit interaction site [polypeptide binding]; other site
718255005951	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
718255005952	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
718255005953	GIY-YIG motif/motif A; other site
718255005954	active site
718255005955	catalytic site [active]
718255005956	putative DNA binding site [nucleotide binding]; other site
718255005957	metal binding site [ion binding]; metal-binding site
718255005958	UvrB/uvrC motif; Region: UVR; pfam02151
718255005959	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
718255005960	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
718255005961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255005962	Walker A motif; other site
718255005963	ATP binding site [chemical binding]; other site
718255005964	Walker B motif; other site
718255005965	arginine finger; other site
718255005966	Peptidase family M41; Region: Peptidase_M41; pfam01434
718255005967	CTP synthetase; Validated; Region: pyrG; PRK05380
718255005968	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
718255005969	Catalytic site [active]
718255005970	active site
718255005971	UTP binding site [chemical binding]; other site
718255005972	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
718255005973	active site
718255005974	putative oxyanion hole; other site
718255005975	catalytic triad [active]
718255005976	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
718255005977	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
718255005978	active site
718255005979	metal binding site [ion binding]; metal-binding site
718255005980	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
718255005981	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
718255005982	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
718255005983	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
718255005984	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255005985	Walker A/P-loop; other site
718255005986	ATP binding site [chemical binding]; other site
718255005987	Q-loop/lid; other site
718255005988	ABC transporter signature motif; other site
718255005989	Walker B; other site
718255005990	D-loop; other site
718255005991	H-loop/switch region; other site
718255005992	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
718255005993	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
718255005994	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
718255005995	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
718255005996	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718255005997	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
718255005998	Ca binding site [ion binding]; other site
718255005999	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
718255006000	active site
718255006001	catalytic site [active]
718255006002	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
718255006003	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255006004	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255006005	dimer interface [polypeptide binding]; other site
718255006006	conserved gate region; other site
718255006007	putative PBP binding loops; other site
718255006008	ABC-ATPase subunit interface; other site
718255006009	4-alpha-glucanotransferase; Provisional; Region: PRK14508
718255006010	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255006011	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255006012	DNA binding site [nucleotide binding]
718255006013	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
718255006014	dimerization interface [polypeptide binding]; other site
718255006015	ligand binding site [chemical binding]; other site
718255006016	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718255006017	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718255006018	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255006019	non-specific DNA binding site [nucleotide binding]; other site
718255006020	salt bridge; other site
718255006021	sequence-specific DNA binding site [nucleotide binding]; other site
718255006022	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255006023	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255006024	dimer interface [polypeptide binding]; other site
718255006025	phosphorylation site [posttranslational modification]
718255006026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255006027	ATP binding site [chemical binding]; other site
718255006028	Mg2+ binding site [ion binding]; other site
718255006029	G-X-G motif; other site
718255006030	Response regulator receiver domain; Region: Response_reg; pfam00072
718255006031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255006032	active site
718255006033	phosphorylation site [posttranslational modification]
718255006034	intermolecular recognition site; other site
718255006035	dimerization interface [polypeptide binding]; other site
718255006036	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
718255006037	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255006038	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
718255006039	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255006040	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718255006041	Protein of unknown function (DUF419); Region: DUF419; pfam04237
718255006042	Transposase domain (DUF772); Region: DUF772; pfam05598
718255006043	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
718255006044	Staphylococcal AgrD protein; Region: AgrD; cl05477
718255006045	Accessory gene regulator B; Region: AgrB; pfam04647
718255006046	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
718255006047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255006048	active site
718255006049	phosphorylation site [posttranslational modification]
718255006050	intermolecular recognition site; other site
718255006051	LytTr DNA-binding domain; Region: LytTR; pfam04397
718255006052	Staphylococcal AgrD protein; Region: AgrD; cl05477
718255006053	TFIIF-interacting CTD phosphatases, including NLI-interacting factor [Transcription]; Region: FCP1; COG5190
718255006054	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255006055	non-specific DNA binding site [nucleotide binding]; other site
718255006056	salt bridge; other site
718255006057	sequence-specific DNA binding site [nucleotide binding]; other site
718255006058	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
718255006059	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255006060	sequence-specific DNA binding site [nucleotide binding]; other site
718255006061	salt bridge; other site
718255006062	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255006063	PemK-like protein; Region: PemK; pfam02452
718255006064	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255006065	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255006066	catalytic residues [active]
718255006067	catalytic nucleophile [active]
718255006068	Recombinase; Region: Recombinase; pfam07508
718255006069	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255006070	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255006071	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255006072	catalytic residues [active]
718255006073	catalytic nucleophile [active]
718255006074	Recombinase; Region: Recombinase; pfam07508
718255006075	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255006076	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255006077	catalytic residues [active]
718255006078	catalytic nucleophile [active]
718255006079	Recombinase; Region: Recombinase; pfam07508
718255006080	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
718255006081	Clp amino terminal domain; Region: Clp_N; pfam02861
718255006082	Clp amino terminal domain; Region: Clp_N; pfam02861
718255006083	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255006084	Walker A motif; other site
718255006085	ATP binding site [chemical binding]; other site
718255006086	Walker B motif; other site
718255006087	arginine finger; other site
718255006088	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255006089	Walker A motif; other site
718255006090	ATP binding site [chemical binding]; other site
718255006091	Walker B motif; other site
718255006092	arginine finger; other site
718255006093	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
718255006094	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255006095	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718255006096	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
718255006097	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
718255006098	active site
718255006099	nucleophile elbow; other site
718255006100	beta-phosphoglucomutase; Region: bPGM; TIGR01990
718255006101	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255006102	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255006103	DNA binding site [nucleotide binding]
718255006104	domain linker motif; other site
718255006105	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
718255006106	dimerization interface [polypeptide binding]; other site
718255006107	ligand binding site [chemical binding]; other site
718255006108	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
718255006109	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
718255006110	putative active site [active]
718255006111	putative catalytic site [active]
718255006112	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
718255006113	Ca binding site [ion binding]; other site
718255006114	active site
718255006115	catalytic site [active]
718255006116	pullulanase, type I; Region: pulA_typeI; TIGR02104
718255006117	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
718255006118	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
718255006119	Ca binding site [ion binding]; other site
718255006120	active site
718255006121	catalytic site [active]
718255006122	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
718255006123	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
718255006124	active site
718255006125	PHP Thumb interface [polypeptide binding]; other site
718255006126	metal binding site [ion binding]; metal-binding site
718255006127	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
718255006128	generic binding surface II; other site
718255006129	generic binding surface I; other site
718255006130	6-phosphofructokinase; Provisional; Region: PRK03202
718255006131	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
718255006132	active site
718255006133	ADP/pyrophosphate binding site [chemical binding]; other site
718255006134	dimerization interface [polypeptide binding]; other site
718255006135	allosteric effector site; other site
718255006136	fructose-1,6-bisphosphate binding site; other site
718255006137	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
718255006138	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
718255006139	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
718255006140	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
718255006141	Fic/DOC family; Region: Fic; cl00960
718255006142	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
718255006143	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
718255006144	CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578
718255006145	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
718255006146	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
718255006147	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
718255006148	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
718255006149	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
718255006150	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
718255006151	P-loop containing region of AAA domain; Region: AAA_29; cl17516
718255006152	AAA domain; Region: AAA_21; pfam13304
718255006153	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
718255006154	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
718255006155	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
718255006156	synthetase active site [active]
718255006157	NTP binding site [chemical binding]; other site
718255006158	metal binding site [ion binding]; metal-binding site
718255006159	Acyltransferase family; Region: Acyl_transf_3; pfam01757
718255006160	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718255006161	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
718255006162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255006163	active site
718255006164	phosphorylation site [posttranslational modification]
718255006165	intermolecular recognition site; other site
718255006166	dimerization interface [polypeptide binding]; other site
718255006167	LytTr DNA-binding domain; Region: LytTR; pfam04397
718255006168	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
718255006169	ATP binding site [chemical binding]; other site
718255006170	Mg2+ binding site [ion binding]; other site
718255006171	G-X-G motif; other site
718255006172	LemA family; Region: LemA; cl00742
718255006173	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
718255006174	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
718255006175	hypothetical protein; Provisional; Region: PRK13663
718255006176	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
718255006177	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718255006178	ABC transporter; Region: ABC_tran_2; pfam12848
718255006179	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255006180	Walker A/P-loop; other site
718255006181	ATP binding site [chemical binding]; other site
718255006182	Q-loop/lid; other site
718255006183	ABC transporter signature motif; other site
718255006184	Walker B; other site
718255006185	D-loop; other site
718255006186	H-loop/switch region; other site
718255006187	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
718255006188	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255006189	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255006190	metal binding site [ion binding]; metal-binding site
718255006191	active site
718255006192	I-site; other site
718255006193	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255006194	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255006195	dimer interface [polypeptide binding]; other site
718255006196	phosphorylation site [posttranslational modification]
718255006197	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
718255006198	Uncharacterized conserved protein [Function unknown]; Region: COG2966
718255006199	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
718255006200	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
718255006201	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
718255006202	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
718255006203	Domain of unknown function (DUF3837); Region: DUF3837; pfam12939
718255006204	SpoVA protein; Region: SpoVA; pfam03862
718255006205	cheY-homologous receiver domain; Region: REC; smart00448
718255006206	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
718255006207	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
718255006208	active site
718255006209	NAD binding site [chemical binding]; other site
718255006210	metal binding site [ion binding]; metal-binding site
718255006211	hybrid cluster protein; Provisional; Region: PRK05290
718255006212	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718255006213	ACS interaction site; other site
718255006214	CODH interaction site; other site
718255006215	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718255006216	ACS interaction site; other site
718255006217	CODH interaction site; other site
718255006218	metal cluster binding site [ion binding]; other site
718255006219	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255006220	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
718255006221	active site
718255006222	motif I; other site
718255006223	motif II; other site
718255006224	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
718255006225	putative substrate binding pocket [chemical binding]; other site
718255006226	AC domain interface; other site
718255006227	catalytic triad [active]
718255006228	AB domain interface; other site
718255006229	interchain disulfide; other site
718255006230	HlyD family secretion protein; Region: HlyD_3; pfam13437
718255006231	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
718255006232	HlyD family secretion protein; Region: HlyD_3; pfam13437
718255006233	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718255006234	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718255006235	FtsX-like permease family; Region: FtsX; pfam02687
718255006236	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718255006237	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718255006238	Walker A/P-loop; other site
718255006239	ATP binding site [chemical binding]; other site
718255006240	Q-loop/lid; other site
718255006241	ABC transporter signature motif; other site
718255006242	Walker B; other site
718255006243	D-loop; other site
718255006244	H-loop/switch region; other site
718255006245	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
718255006246	A new structural DNA glycosylase; Region: AlkD_like; cd06561
718255006247	active site
718255006248	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
718255006249	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
718255006250	active site
718255006251	dimerization interface [polypeptide binding]; other site
718255006252	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
718255006253	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
718255006254	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
718255006255	Probable beta-xylosidase; Provisional; Region: PLN03080
718255006256	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255006257	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255006258	HAMP domain; Region: HAMP; pfam00672
718255006259	Histidine kinase; Region: His_kinase; pfam06580
718255006260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255006261	ATP binding site [chemical binding]; other site
718255006262	Mg2+ binding site [ion binding]; other site
718255006263	G-X-G motif; other site
718255006264	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
718255006265	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255006266	active site
718255006267	phosphorylation site [posttranslational modification]
718255006268	intermolecular recognition site; other site
718255006269	dimerization interface [polypeptide binding]; other site
718255006270	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255006271	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255006272	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718255006273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255006274	dimer interface [polypeptide binding]; other site
718255006275	conserved gate region; other site
718255006276	putative PBP binding loops; other site
718255006277	ABC-ATPase subunit interface; other site
718255006278	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255006279	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255006280	conserved gate region; other site
718255006281	ABC-ATPase subunit interface; other site
718255006282	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
718255006283	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
718255006284	active site
718255006285	catalytic triad [active]
718255006286	oxyanion hole [active]
718255006287	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
718255006288	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
718255006289	inhibitor binding site; inhibition site
718255006290	active site
718255006291	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255006292	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255006293	DNA binding site [nucleotide binding]
718255006294	domain linker motif; other site
718255006295	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
718255006296	dimerization interface [polypeptide binding]; other site
718255006297	ligand binding site [chemical binding]; other site
718255006298	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
718255006299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255006300	dimer interface [polypeptide binding]; other site
718255006301	conserved gate region; other site
718255006302	putative PBP binding loops; other site
718255006303	ABC-ATPase subunit interface; other site
718255006304	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255006305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255006306	dimer interface [polypeptide binding]; other site
718255006307	conserved gate region; other site
718255006308	putative PBP binding loops; other site
718255006309	ABC-ATPase subunit interface; other site
718255006310	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255006311	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255006312	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255006313	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
718255006314	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718255006315	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718255006316	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718255006317	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
718255006318	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
718255006319	galactokinase; Provisional; Region: PRK05322
718255006320	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
718255006321	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
718255006322	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
718255006323	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
718255006324	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
718255006325	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
718255006326	aspartate aminotransferase; Provisional; Region: PRK06836
718255006327	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718255006328	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255006329	homodimer interface [polypeptide binding]; other site
718255006330	catalytic residue [active]
718255006331	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
718255006332	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718255006333	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255006334	homodimer interface [polypeptide binding]; other site
718255006335	catalytic residue [active]
718255006336	CAAX protease self-immunity; Region: Abi; pfam02517
718255006337	Trp repressor protein; Region: Trp_repressor; cl17266
718255006338	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
718255006339	Part of AAA domain; Region: AAA_19; pfam13245
718255006340	Family description; Region: UvrD_C_2; pfam13538
718255006341	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
718255006342	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255006343	S-adenosylmethionine binding site [chemical binding]; other site
718255006344	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255006345	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255006346	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718255006347	dimerization interface [polypeptide binding]; other site
718255006348	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
718255006349	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
718255006350	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718255006351	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
718255006352	active site
718255006353	catalytic tetrad [active]
718255006354	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
718255006355	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
718255006356	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
718255006357	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718255006358	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
718255006359	active site
718255006360	catalytic tetrad [active]
718255006361	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
718255006362	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
718255006363	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
718255006364	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
718255006365	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
718255006366	Flavoprotein; Region: Flavoprotein; pfam02441
718255006367	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255006368	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255006369	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718255006370	dimerization interface [polypeptide binding]; other site
718255006371	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
718255006372	MFS/sugar transport protein; Region: MFS_2; pfam13347
718255006373	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
718255006374	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255006375	Coenzyme A binding pocket [chemical binding]; other site
718255006376	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
718255006377	HSP70 interaction site [polypeptide binding]; other site
718255006378	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718255006379	catalytic core [active]
718255006380	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
718255006381	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
718255006382	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
718255006383	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
718255006384	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255006385	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255006386	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255006387	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255006388	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
718255006389	Walker A/P-loop; other site
718255006390	ATP binding site [chemical binding]; other site
718255006391	Q-loop/lid; other site
718255006392	ABC transporter signature motif; other site
718255006393	Walker B; other site
718255006394	D-loop; other site
718255006395	H-loop/switch region; other site
718255006396	Transcriptional regulators [Transcription]; Region: FadR; COG2186
718255006397	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718255006398	DNA-binding site [nucleotide binding]; DNA binding site
718255006399	FCD domain; Region: FCD; pfam07729
718255006400	Cache domain; Region: Cache_1; pfam02743
718255006401	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255006402	dimerization interface [polypeptide binding]; other site
718255006403	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255006404	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255006405	metal binding site [ion binding]; metal-binding site
718255006406	active site
718255006407	I-site; other site
718255006408	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255006409	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255006410	dimer interface [polypeptide binding]; other site
718255006411	putative CheW interface [polypeptide binding]; other site
718255006412	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
718255006413	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
718255006414	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
718255006415	putative active site [active]
718255006416	catalytic site [active]
718255006417	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
718255006418	putative active site [active]
718255006419	catalytic site [active]
718255006420	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
718255006421	synthetase active site [active]
718255006422	NTP binding site [chemical binding]; other site
718255006423	metal binding site [ion binding]; metal-binding site
718255006424	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
718255006425	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718255006426	catalytic residue [active]
718255006427	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
718255006428	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
718255006429	DNA-binding site [nucleotide binding]; DNA binding site
718255006430	RNA-binding motif; other site
718255006431	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
718255006432	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
718255006433	active site
718255006434	metal binding site [ion binding]; metal-binding site
718255006435	EDD domain protein, DegV family; Region: DegV; TIGR00762
718255006436	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
718255006437	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
718255006438	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718255006439	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
718255006440	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
718255006441	active site
718255006442	catalytic triad [active]
718255006443	oxyanion hole [active]
718255006444	enolase; Provisional; Region: eno; PRK00077
718255006445	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
718255006446	dimer interface [polypeptide binding]; other site
718255006447	metal binding site [ion binding]; metal-binding site
718255006448	substrate binding pocket [chemical binding]; other site
718255006449	ribonuclease R; Region: RNase_R; TIGR02063
718255006450	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
718255006451	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
718255006452	RNB domain; Region: RNB; pfam00773
718255006453	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
718255006454	RNA binding site [nucleotide binding]; other site
718255006455	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
718255006456	SmpB-tmRNA interface; other site
718255006457	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
718255006458	putative active site [active]
718255006459	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255006460	DNA binding site [nucleotide binding]
718255006461	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
718255006462	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
718255006463	ligand binding site [chemical binding]; other site
718255006464	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
718255006465	N- and C-terminal domain interface [polypeptide binding]; other site
718255006466	D-xylulose kinase; Region: XylB; TIGR01312
718255006467	active site
718255006468	MgATP binding site [chemical binding]; other site
718255006469	catalytic site [active]
718255006470	metal binding site [ion binding]; metal-binding site
718255006471	xylulose binding site [chemical binding]; other site
718255006472	homodimer interface [polypeptide binding]; other site
718255006473	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
718255006474	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
718255006475	hexamer (dimer of trimers) interface [polypeptide binding]; other site
718255006476	substrate binding site [chemical binding]; other site
718255006477	trimer interface [polypeptide binding]; other site
718255006478	Mn binding site [ion binding]; other site
718255006479	Bacterial SH3 domain; Region: SH3_3; pfam08239
718255006480	Bacterial SH3 domain; Region: SH3_3; pfam08239
718255006481	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718255006482	NlpC/P60 family; Region: NLPC_P60; pfam00877
718255006483	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
718255006484	regulatory protein interface [polypeptide binding]; other site
718255006485	regulatory phosphorylation site [posttranslational modification]; other site
718255006486	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
718255006487	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
718255006488	DEAD_2; Region: DEAD_2; pfam06733
718255006489	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
718255006490	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255006491	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255006492	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718255006493	dimerization interface [polypeptide binding]; other site
718255006494	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
718255006495	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
718255006496	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
718255006497	dimerization interface [polypeptide binding]; other site
718255006498	ATP binding site [chemical binding]; other site
718255006499	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
718255006500	dimerization interface [polypeptide binding]; other site
718255006501	ATP binding site [chemical binding]; other site
718255006502	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
718255006503	putative active site [active]
718255006504	catalytic triad [active]
718255006505	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
718255006506	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
718255006507	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
718255006508	DHHW protein; Region: DHHW; pfam14286
718255006509	DHHW protein; Region: DHHW; pfam14286
718255006510	histidinol-phosphatase; Provisional; Region: PRK05588
718255006511	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
718255006512	active site
718255006513	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
718255006514	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
718255006515	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
718255006516	Phosphoglycerate kinase; Region: PGK; pfam00162
718255006517	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
718255006518	substrate binding site [chemical binding]; other site
718255006519	hinge regions; other site
718255006520	ADP binding site [chemical binding]; other site
718255006521	catalytic site [active]
718255006522	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
718255006523	dimer interface [polypeptide binding]; other site
718255006524	catalytic triad [active]
718255006525	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
718255006526	phosphoglyceromutase; Provisional; Region: PRK05434
718255006527	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
718255006528	ATP binding site [chemical binding]; other site
718255006529	active site
718255006530	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
718255006531	substrate binding site [chemical binding]; other site
718255006532	amidophosphoribosyltransferase; Provisional; Region: PRK05793
718255006533	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
718255006534	active site
718255006535	tetramer interface [polypeptide binding]; other site
718255006536	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718255006537	active site
718255006538	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
718255006539	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
718255006540	tetramer interface [polypeptide binding]; other site
718255006541	active site
718255006542	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
718255006543	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
718255006544	dimer interface [polypeptide binding]; other site
718255006545	active site
718255006546	metal binding site [ion binding]; metal-binding site
718255006547	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
718255006548	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718255006549	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
718255006550	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
718255006551	putative N- and C-terminal domain interface [polypeptide binding]; other site
718255006552	putative active site [active]
718255006553	MgATP binding site [chemical binding]; other site
718255006554	catalytic site [active]
718255006555	metal binding site [ion binding]; metal-binding site
718255006556	putative carbohydrate binding site [chemical binding]; other site
718255006557	L-arabinose isomerase; Provisional; Region: PRK02929
718255006558	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
718255006559	hexamer (dimer of trimers) interface [polypeptide binding]; other site
718255006560	trimer interface [polypeptide binding]; other site
718255006561	substrate binding site [chemical binding]; other site
718255006562	Mn binding site [ion binding]; other site
718255006563	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
718255006564	active site
718255006565	intersubunit interactions; other site
718255006566	catalytic residue [active]
718255006567	transketolase; Reviewed; Region: PRK05899
718255006568	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
718255006569	TPP-binding site [chemical binding]; other site
718255006570	dimer interface [polypeptide binding]; other site
718255006571	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
718255006572	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
718255006573	PYR/PP interface [polypeptide binding]; other site
718255006574	dimer interface [polypeptide binding]; other site
718255006575	TPP binding site [chemical binding]; other site
718255006576	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
718255006577	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
718255006578	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
718255006579	intersubunit interface [polypeptide binding]; other site
718255006580	active site
718255006581	Zn2+ binding site [ion binding]; other site
718255006582	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
718255006583	active site
718255006584	catalytic residues [active]
718255006585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255006586	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255006587	ATP binding site [chemical binding]; other site
718255006588	G-X-G motif; other site
718255006589	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
718255006590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255006591	active site
718255006592	dimerization interface [polypeptide binding]; other site
718255006593	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
718255006594	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
718255006595	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
718255006596	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
718255006597	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
718255006598	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
718255006599	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
718255006600	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
718255006601	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
718255006602	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
718255006603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255006604	ATP binding site [chemical binding]; other site
718255006605	Walker A motif; other site
718255006606	Walker B motif; other site
718255006607	Integrase core domain; Region: rve; pfam00665
718255006608	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
718255006609	Domain of unknown function, E. rectale Gene description (DUF3879); Region: DUF3879; pfam12995
718255006610	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255006611	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
718255006612	active site
718255006613	phosphorylation site [posttranslational modification]
718255006614	intermolecular recognition site; other site
718255006615	dimerization interface [polypeptide binding]; other site
718255006616	LytTr DNA-binding domain; Region: LytTR; smart00850
718255006617	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
718255006618	ATP binding site [chemical binding]; other site
718255006619	Mg2+ binding site [ion binding]; other site
718255006620	G-X-G motif; other site
718255006621	Transposase; Region: DEDD_Tnp_IS110; pfam01548
718255006622	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
718255006623	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
718255006624	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255006625	dimerization interface [polypeptide binding]; other site
718255006626	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255006627	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
718255006628	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
718255006629	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718255006630	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718255006631	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255006632	DNA binding residues [nucleotide binding]
718255006633	Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112
718255006634	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
718255006635	MFS/sugar transport protein; Region: MFS_2; pfam13347
718255006636	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
718255006637	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718255006638	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718255006639	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718255006640	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
718255006641	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
718255006642	active site
718255006643	dimer interfaces [polypeptide binding]; other site
718255006644	catalytic residues [active]
718255006645	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255006646	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255006647	non-specific DNA binding site [nucleotide binding]; other site
718255006648	salt bridge; other site
718255006649	sequence-specific DNA binding site [nucleotide binding]; other site
718255006650	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
718255006651	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255006652	active site
718255006653	phosphorylation site [posttranslational modification]
718255006654	intermolecular recognition site; other site
718255006655	dimerization interface [polypeptide binding]; other site
718255006656	LytTr DNA-binding domain; Region: LytTR; pfam04397
718255006657	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
718255006658	catalytic site [active]
718255006659	YcfA-like protein; Region: YcfA; pfam07927
718255006660	Double zinc ribbon; Region: DZR; pfam12773
718255006661	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
718255006662	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
718255006663	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255006664	non-specific DNA binding site [nucleotide binding]; other site
718255006665	salt bridge; other site
718255006666	sequence-specific DNA binding site [nucleotide binding]; other site
718255006667	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
718255006668	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255006669	Walker A/P-loop; other site
718255006670	ATP binding site [chemical binding]; other site
718255006671	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
718255006672	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
718255006673	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
718255006674	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
718255006675	active site
718255006676	ATP binding site [chemical binding]; other site
718255006677	substrate binding site [chemical binding]; other site
718255006678	activation loop (A-loop); other site
718255006679	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
718255006680	metal ion-dependent adhesion site (MIDAS); other site
718255006681	Protein phosphatase 2C; Region: PP2C_2; pfam13672
718255006682	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
718255006683	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
718255006684	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
718255006685	active site
718255006686	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
718255006687	hypothetical protein; Validated; Region: PRK00124
718255006688	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
718255006689	ArsC family; Region: ArsC; pfam03960
718255006690	catalytic residue [active]
718255006691	Y-family of DNA polymerases; Region: PolY; cl12025
718255006692	active site
718255006693	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
718255006694	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
718255006695	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
718255006696	G1 box; other site
718255006697	putative GEF interaction site [polypeptide binding]; other site
718255006698	GTP/Mg2+ binding site [chemical binding]; other site
718255006699	Switch I region; other site
718255006700	G2 box; other site
718255006701	G3 box; other site
718255006702	Switch II region; other site
718255006703	G4 box; other site
718255006704	G5 box; other site
718255006705	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
718255006706	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
718255006707	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
718255006708	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255006709	DNA binding residues [nucleotide binding]
718255006710	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718255006711	AAA domain; Region: AAA_25; pfam13481
718255006712	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718255006713	Walker A motif; other site
718255006714	ATP binding site [chemical binding]; other site
718255006715	Walker B motif; other site
718255006716	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
718255006717	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
718255006718	ParB-like nuclease domain; Region: ParBc; pfam02195
718255006719	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
718255006720	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255006721	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
718255006722	putative catalytic residues [active]
718255006723	catalytic nucleophile [active]
718255006724	Recombinase; Region: Recombinase; pfam07508
718255006725	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255006726	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
718255006727	Domain of unknown function (DUF955); Region: DUF955; pfam06114
718255006728	YodL-like; Region: YodL; pfam14191
718255006729	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
718255006730	active site
718255006731	NTP binding site [chemical binding]; other site
718255006732	metal binding triad [ion binding]; metal-binding site
718255006733	antibiotic binding site [chemical binding]; other site
718255006734	Domain of unknown function (DUF4316); Region: DUF4316; pfam14195
718255006735	Domain of unknown function (DUF4319); Region: DUF4319; pfam14203
718255006736	Abi-like protein; Region: Abi_2; pfam07751
718255006737	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
718255006738	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
718255006739	Response regulator receiver domain; Region: Response_reg; pfam00072
718255006740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255006741	active site
718255006742	phosphorylation site [posttranslational modification]
718255006743	intermolecular recognition site; other site
718255006744	dimerization interface [polypeptide binding]; other site
718255006745	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
718255006746	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255006747	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255006748	DNA binding site [nucleotide binding]
718255006749	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
718255006750	ADP-ribose binding site [chemical binding]; other site
718255006751	Uncharacterized conserved protein (DUF2369); Region: DUF2369; pfam10179
718255006752	Sortase family; Region: Sortase; pfam04203
718255006753	active site
718255006754	catalytic site [active]
718255006755	Methyltransferase domain; Region: Methyltransf_26; pfam13659
718255006756	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
718255006757	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
718255006758	DEAD-like helicases superfamily; Region: DEXDc; smart00487
718255006759	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
718255006760	helicase superfamily c-terminal domain; Region: HELICc; smart00490
718255006761	nucleotide binding region [chemical binding]; other site
718255006762	ATP-binding site [chemical binding]; other site
718255006763	DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207
718255006764	PrgI family protein; Region: PrgI; pfam12666
718255006765	Domain of unknown function (DUF4313); Region: DUF4313; pfam14190
718255006766	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
718255006767	Myosin heavy chain [Cytoskeleton]; Region: COG5022
718255006768	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
718255006769	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
718255006770	Toprim-like; Region: Toprim_2; pfam13155
718255006771	active site
718255006772	metal binding site [ion binding]; metal-binding site
718255006773	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
718255006774	MPN+ (JAMM) motif; other site
718255006775	Zinc-binding site [ion binding]; other site
718255006776	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255006777	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255006778	non-specific DNA binding site [nucleotide binding]; other site
718255006779	salt bridge; other site
718255006780	sequence-specific DNA binding site [nucleotide binding]; other site
718255006781	AAA domain; Region: AAA_21; pfam13304
718255006782	AAA domain; Region: AAA_21; pfam13304
718255006783	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
718255006784	active site
718255006785	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
718255006786	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
718255006787	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
718255006788	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
718255006789	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255006790	active site
718255006791	DNA binding site [nucleotide binding]
718255006792	Int/Topo IB signature motif; other site
718255006793	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
718255006794	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
718255006795	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255006796	S-adenosylmethionine binding site [chemical binding]; other site
718255006797	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
718255006798	Helix-turn-helix domain; Region: HTH_17; cl17695
718255006799	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
718255006800	ParB-like nuclease domain; Region: ParB; smart00470
718255006801	Helix-turn-helix domain; Region: HTH_17; pfam12728
718255006802	Fic family protein [Function unknown]; Region: COG3177
718255006803	Fic/DOC family; Region: Fic; pfam02661
718255006804	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
718255006805	non-specific DNA interactions [nucleotide binding]; other site
718255006806	DNA binding site [nucleotide binding]
718255006807	sequence specific DNA binding site [nucleotide binding]; other site
718255006808	putative cAMP binding site [chemical binding]; other site
718255006809	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255006810	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255006811	active site
718255006812	phosphorylation site [posttranslational modification]
718255006813	intermolecular recognition site; other site
718255006814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255006815	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255006816	dimerization interface [polypeptide binding]; other site
718255006817	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255006818	dimer interface [polypeptide binding]; other site
718255006819	phosphorylation site [posttranslational modification]
718255006820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255006821	ATP binding site [chemical binding]; other site
718255006822	Mg2+ binding site [ion binding]; other site
718255006823	G-X-G motif; other site
718255006824	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
718255006825	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
718255006826	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
718255006827	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
718255006828	Walker A/P-loop; other site
718255006829	ATP binding site [chemical binding]; other site
718255006830	Q-loop/lid; other site
718255006831	ABC transporter signature motif; other site
718255006832	Walker B; other site
718255006833	D-loop; other site
718255006834	H-loop/switch region; other site
718255006835	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
718255006836	CpXC protein; Region: CpXC; pfam14353
718255006837	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255006838	non-specific DNA binding site [nucleotide binding]; other site
718255006839	salt bridge; other site
718255006840	sequence-specific DNA binding site [nucleotide binding]; other site
718255006841	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
718255006842	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718255006843	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
718255006844	active site
718255006845	catalytic tetrad [active]
718255006846	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
718255006847	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255006848	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718255006849	Right handed beta helix region; Region: Beta_helix; pfam13229
718255006850	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
718255006851	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
718255006852	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
718255006853	inhibitor binding site; inhibition site
718255006854	active site
718255006855	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
718255006856	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
718255006857	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
718255006858	catalytic tetrad [active]
718255006859	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
718255006860	Beta-lactamase; Region: Beta-lactamase; pfam00144
718255006861	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
718255006862	Beta-lactamase; Region: Beta-lactamase; pfam00144
718255006863	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
718255006864	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255006865	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
718255006866	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718255006867	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255006868	dimer interface [polypeptide binding]; other site
718255006869	conserved gate region; other site
718255006870	putative PBP binding loops; other site
718255006871	ABC-ATPase subunit interface; other site
718255006872	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255006873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255006874	dimer interface [polypeptide binding]; other site
718255006875	conserved gate region; other site
718255006876	putative PBP binding loops; other site
718255006877	ABC-ATPase subunit interface; other site
718255006878	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255006879	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255006880	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255006881	DNA binding site [nucleotide binding]
718255006882	domain linker motif; other site
718255006883	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
718255006884	dimerization interface [polypeptide binding]; other site
718255006885	ligand binding site [chemical binding]; other site
718255006886	N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858
718255006887	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
718255006888	Putative esterase; Region: Esterase; pfam00756
718255006889	N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858
718255006890	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
718255006891	Putative esterase; Region: Esterase; pfam00756
718255006892	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
718255006893	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
718255006894	Putative esterase; Region: Esterase; pfam00756
718255006895	Putative esterase; Region: Esterase; pfam00756
718255006896	S-formylglutathione hydrolase; Region: PLN02442
718255006897	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255006898	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
718255006899	Right handed beta helix region; Region: Beta_helix; pfam13229
718255006900	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
718255006901	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
718255006902	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
718255006903	substrate binding site [chemical binding]; other site
718255006904	active site
718255006905	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
718255006906	ligand binding site [chemical binding]; other site
718255006907	metal binding site [ion binding]; metal-binding site
718255006908	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
718255006909	binding surface
718255006910	TPR motif; other site
718255006911	Tetratricopeptide repeat; Region: TPR_12; pfam13424
718255006912	Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194
718255006913	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
718255006914	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
718255006915	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
718255006916	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255006917	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255006918	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
718255006919	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
718255006920	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
718255006921	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255006922	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255006923	non-specific DNA binding site [nucleotide binding]; other site
718255006924	salt bridge; other site
718255006925	sequence-specific DNA binding site [nucleotide binding]; other site
718255006926	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255006927	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255006928	non-specific DNA binding site [nucleotide binding]; other site
718255006929	salt bridge; other site
718255006930	sequence-specific DNA binding site [nucleotide binding]; other site
718255006931	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
718255006932	AAA domain; Region: AAA_14; pfam13173
718255006933	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
718255006934	active site
718255006935	putative interdomain interaction site [polypeptide binding]; other site
718255006936	putative metal-binding site [ion binding]; other site
718255006937	putative nucleotide binding site [chemical binding]; other site
718255006938	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
718255006939	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
718255006940	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718255006941	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718255006942	Walker A/P-loop; other site
718255006943	ATP binding site [chemical binding]; other site
718255006944	Q-loop/lid; other site
718255006945	ABC transporter signature motif; other site
718255006946	Walker B; other site
718255006947	D-loop; other site
718255006948	H-loop/switch region; other site
718255006949	FtsX-like permease family; Region: FtsX; pfam02687
718255006950	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
718255006951	FtsX-like permease family; Region: FtsX; pfam02687
718255006952	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
718255006953	active site
718255006954	metal binding site [ion binding]; metal-binding site
718255006955	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
718255006956	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
718255006957	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255006958	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255006959	dimer interface [polypeptide binding]; other site
718255006960	putative CheW interface [polypeptide binding]; other site
718255006961	Flavodoxin domain; Region: Flavodoxin_3; pfam12641
718255006962	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
718255006963	homodimer interface [polypeptide binding]; other site
718255006964	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
718255006965	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
718255006966	active site
718255006967	homodimer interface [polypeptide binding]; other site
718255006968	catalytic site [active]
718255006969	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255006970	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
718255006971	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718255006972	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255006973	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255006974	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
718255006975	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
718255006976	transmembrane helices; other site
718255006977	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
718255006978	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
718255006979	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
718255006980	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718255006981	dimerization interface [polypeptide binding]; other site
718255006982	putative Zn2+ binding site [ion binding]; other site
718255006983	putative DNA binding site [nucleotide binding]; other site
718255006984	hypothetical protein; Provisional; Region: PHA03169
718255006985	peptidase T; Region: peptidase-T; TIGR01882
718255006986	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
718255006987	metal binding site [ion binding]; metal-binding site
718255006988	dimer interface [polypeptide binding]; other site
718255006989	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255006990	S-adenosylmethionine binding site [chemical binding]; other site
718255006991	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
718255006992	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
718255006993	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
718255006994	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
718255006995	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
718255006996	GTP binding site; other site
718255006997	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
718255006998	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
718255006999	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718255007000	catalytic residue [active]
718255007001	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
718255007002	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
718255007003	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
718255007004	active site
718255007005	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
718255007006	DNA polymerase III subunit delta'; Validated; Region: PRK08485
718255007007	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
718255007008	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
718255007009	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
718255007010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255007011	S-adenosylmethionine binding site [chemical binding]; other site
718255007012	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
718255007013	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255007014	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255007015	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
718255007016	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
718255007017	putative ligand binding residues [chemical binding]; other site
718255007018	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
718255007019	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718255007020	ABC-ATPase subunit  interface; other site
718255007021	dimer interface [polypeptide binding]; other site
718255007022	putative PBP binding regions; other site
718255007023	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
718255007024	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718255007025	ABC-ATPase subunit  interface; other site
718255007026	dimer interface [polypeptide binding]; other site
718255007027	putative PBP binding regions; other site
718255007028	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
718255007029	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
718255007030	Walker A/P-loop; other site
718255007031	ATP binding site [chemical binding]; other site
718255007032	Q-loop/lid; other site
718255007033	ABC transporter signature motif; other site
718255007034	Walker B; other site
718255007035	D-loop; other site
718255007036	H-loop/switch region; other site
718255007037	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
718255007038	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
718255007039	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
718255007040	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
718255007041	Isochorismatase family; Region: Isochorismatase; pfam00857
718255007042	catalytic triad [active]
718255007043	conserved cis-peptide bond; other site
718255007044	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
718255007045	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718255007046	DNA binding residues [nucleotide binding]
718255007047	dimerization interface [polypeptide binding]; other site
718255007048	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
718255007049	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
718255007050	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
718255007051	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
718255007052	urea carboxylase; Region: urea_carbox; TIGR02712
718255007053	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
718255007054	ATP-grasp domain; Region: ATP-grasp_4; cl17255
718255007055	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
718255007056	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
718255007057	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
718255007058	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
718255007059	carboxyltransferase (CT) interaction site; other site
718255007060	biotinylation site [posttranslational modification]; other site
718255007061	Amidase; Region: Amidase; cl11426
718255007062	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
718255007063	Nitrogen regulatory protein P-II; Region: P-II; smart00938
718255007064	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
718255007065	Nitrogen regulatory protein P-II; Region: P-II; smart00938
718255007066	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
718255007067	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718255007068	substrate binding pocket [chemical binding]; other site
718255007069	membrane-bound complex binding site; other site
718255007070	hinge residues; other site
718255007071	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
718255007072	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
718255007073	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
718255007074	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
718255007075	Walker A/P-loop; other site
718255007076	ATP binding site [chemical binding]; other site
718255007077	Q-loop/lid; other site
718255007078	ABC transporter signature motif; other site
718255007079	Walker B; other site
718255007080	D-loop; other site
718255007081	H-loop/switch region; other site
718255007082	Predicted methyltransferases [General function prediction only]; Region: COG0313
718255007083	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
718255007084	putative SAM binding site [chemical binding]; other site
718255007085	putative homodimer interface [polypeptide binding]; other site
718255007086	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
718255007087	Response regulator receiver domain; Region: Response_reg; pfam00072
718255007088	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255007089	active site
718255007090	phosphorylation site [posttranslational modification]
718255007091	intermolecular recognition site; other site
718255007092	dimerization interface [polypeptide binding]; other site
718255007093	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255007094	metal binding site [ion binding]; metal-binding site
718255007095	active site
718255007096	I-site; other site
718255007097	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718255007098	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
718255007099	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
718255007100	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
718255007101	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255007102	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255007103	dimer interface [polypeptide binding]; other site
718255007104	putative CheW interface [polypeptide binding]; other site
718255007105	NAD-dependent deacetylase; Provisional; Region: PRK00481
718255007106	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
718255007107	Tubby C 2; Region: Tub_2; cl02043
718255007108	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
718255007109	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
718255007110	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
718255007111	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
718255007112	dimer interface [polypeptide binding]; other site
718255007113	ssDNA binding site [nucleotide binding]; other site
718255007114	tetramer (dimer of dimers) interface [polypeptide binding]; other site
718255007115	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
718255007116	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
718255007117	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
718255007118	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
718255007119	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
718255007120	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
718255007121	DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005
718255007122	Ca binding site [ion binding]; other site
718255007123	carbohydrate binding site [chemical binding]; other site
718255007124	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
718255007125	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
718255007126	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
718255007127	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
718255007128	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255007129	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255007130	dimer interface [polypeptide binding]; other site
718255007131	conserved gate region; other site
718255007132	putative PBP binding loops; other site
718255007133	ABC-ATPase subunit interface; other site
718255007134	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
718255007135	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
718255007136	active site
718255007137	homodimer interface [polypeptide binding]; other site
718255007138	catalytic site [active]
718255007139	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
718255007140	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
718255007141	substrate binding [chemical binding]; other site
718255007142	active site
718255007143	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255007144	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255007145	DNA binding site [nucleotide binding]
718255007146	domain linker motif; other site
718255007147	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718255007148	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
718255007149	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
718255007150	Ca binding site [ion binding]; other site
718255007151	active site
718255007152	catalytic site [active]
718255007153	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
718255007154	Melibiase; Region: Melibiase; pfam02065
718255007155	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718255007156	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
718255007157	putative substrate binding site [chemical binding]; other site
718255007158	putative ATP binding site [chemical binding]; other site
718255007159	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
718255007160	DHH family; Region: DHH; pfam01368
718255007161	DHHA1 domain; Region: DHHA1; pfam02272
718255007162	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
718255007163	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
718255007164	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
718255007165	replicative DNA helicase; Region: DnaB; TIGR00665
718255007166	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
718255007167	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
718255007168	Walker A motif; other site
718255007169	ATP binding site [chemical binding]; other site
718255007170	Walker B motif; other site
718255007171	DNA binding loops [nucleotide binding]
718255007172	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552
718255007173	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
718255007174	active site
718255007175	NTP binding site [chemical binding]; other site
718255007176	metal binding triad [ion binding]; metal-binding site
718255007177	antibiotic binding site [chemical binding]; other site
718255007178	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255007179	Walker A motif; other site
718255007180	ATP binding site [chemical binding]; other site
718255007181	Walker B motif; other site
718255007182	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
718255007183	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
718255007184	active site
718255007185	catalytic residues [active]
718255007186	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
718255007187	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
718255007188	Low molecular weight phosphatase family; Region: LMWPc; cl00105
718255007189	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
718255007190	active site
718255007191	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718255007192	active site
718255007193	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
718255007194	catalytic motif [active]
718255007195	Zn binding site [ion binding]; other site
718255007196	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
718255007197	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
718255007198	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
718255007199	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
718255007200	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
718255007201	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
718255007202	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
718255007203	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
718255007204	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
718255007205	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
718255007206	beta subunit interaction interface [polypeptide binding]; other site
718255007207	Walker A motif; other site
718255007208	ATP binding site [chemical binding]; other site
718255007209	Walker B motif; other site
718255007210	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
718255007211	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
718255007212	core domain interface [polypeptide binding]; other site
718255007213	delta subunit interface [polypeptide binding]; other site
718255007214	epsilon subunit interface [polypeptide binding]; other site
718255007215	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
718255007216	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
718255007217	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
718255007218	alpha subunit interaction interface [polypeptide binding]; other site
718255007219	Walker A motif; other site
718255007220	ATP binding site [chemical binding]; other site
718255007221	Walker B motif; other site
718255007222	inhibitor binding site; inhibition site
718255007223	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
718255007224	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
718255007225	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
718255007226	gamma subunit interface [polypeptide binding]; other site
718255007227	epsilon subunit interface [polypeptide binding]; other site
718255007228	LBP interface [polypeptide binding]; other site
718255007229	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
718255007230	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255007231	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
718255007232	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718255007233	catalytic core [active]
718255007234	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
718255007235	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
718255007236	putative substrate binding site [chemical binding]; other site
718255007237	putative ATP binding site [chemical binding]; other site
718255007238	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
718255007239	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
718255007240	active site
718255007241	phosphorylation site [posttranslational modification]
718255007242	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
718255007243	active site
718255007244	P-loop; other site
718255007245	phosphorylation site [posttranslational modification]
718255007246	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
718255007247	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718255007248	dimerization domain swap beta strand [polypeptide binding]; other site
718255007249	regulatory protein interface [polypeptide binding]; other site
718255007250	active site
718255007251	regulatory phosphorylation site [posttranslational modification]; other site
718255007252	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
718255007253	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
718255007254	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
718255007255	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
718255007256	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
718255007257	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
718255007258	active site
718255007259	VanW like protein; Region: VanW; pfam04294
718255007260	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
718255007261	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
718255007262	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
718255007263	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
718255007264	Walker A/P-loop; other site
718255007265	ATP binding site [chemical binding]; other site
718255007266	Q-loop/lid; other site
718255007267	ABC transporter signature motif; other site
718255007268	Walker B; other site
718255007269	D-loop; other site
718255007270	H-loop/switch region; other site
718255007271	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
718255007272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255007273	dimer interface [polypeptide binding]; other site
718255007274	conserved gate region; other site
718255007275	putative PBP binding loops; other site
718255007276	ABC-ATPase subunit interface; other site
718255007277	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
718255007278	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255007279	dimer interface [polypeptide binding]; other site
718255007280	conserved gate region; other site
718255007281	ABC-ATPase subunit interface; other site
718255007282	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
718255007283	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
718255007284	active site
718255007285	metal binding site [ion binding]; metal-binding site
718255007286	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
718255007287	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
718255007288	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
718255007289	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
718255007290	active site
718255007291	dimer interface [polypeptide binding]; other site
718255007292	motif 1; other site
718255007293	motif 2; other site
718255007294	motif 3; other site
718255007295	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
718255007296	anticodon binding site; other site
718255007297	HAMP domain; Region: HAMP; pfam00672
718255007298	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255007299	dimer interface [polypeptide binding]; other site
718255007300	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
718255007301	putative CheW interface [polypeptide binding]; other site
718255007302	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
718255007303	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
718255007304	active site
718255007305	metal binding site [ion binding]; metal-binding site
718255007306	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
718255007307	AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271
718255007308	Transcriptional regulator [Transcription]; Region: LytR; COG1316
718255007309	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255007310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255007311	active site
718255007312	phosphorylation site [posttranslational modification]
718255007313	intermolecular recognition site; other site
718255007314	dimerization interface [polypeptide binding]; other site
718255007315	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255007316	DNA binding site [nucleotide binding]
718255007317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255007318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255007319	dimer interface [polypeptide binding]; other site
718255007320	phosphorylation site [posttranslational modification]
718255007321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255007322	ATP binding site [chemical binding]; other site
718255007323	Mg2+ binding site [ion binding]; other site
718255007324	G-X-G motif; other site
718255007325	putative hydratase; Provisional; Region: PRK11413
718255007326	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
718255007327	substrate binding site [chemical binding]; other site
718255007328	ligand binding site [chemical binding]; other site
718255007329	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
718255007330	substrate binding site [chemical binding]; other site
718255007331	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
718255007332	Domain of unknown function DUF20; Region: UPF0118; pfam01594
718255007333	glycogen branching enzyme; Provisional; Region: PRK12313
718255007334	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
718255007335	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
718255007336	active site
718255007337	catalytic site [active]
718255007338	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
718255007339	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
718255007340	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
718255007341	active site
718255007342	metal binding site [ion binding]; metal-binding site
718255007343	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
718255007344	active site
718255007345	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
718255007346	Catalytic domain of Protein Kinases; Region: PKc; cd00180
718255007347	active site
718255007348	ATP binding site [chemical binding]; other site
718255007349	substrate binding site [chemical binding]; other site
718255007350	activation loop (A-loop); other site
718255007351	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
718255007352	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
718255007353	flagellin; Provisional; Region: PRK12806
718255007354	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
718255007355	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
718255007356	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
718255007357	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
718255007358	ATP binding site [chemical binding]; other site
718255007359	Walker A motif; other site
718255007360	hexamer interface [polypeptide binding]; other site
718255007361	Walker B motif; other site
718255007362	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
718255007363	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
718255007364	TadE-like protein; Region: TadE; pfam07811
718255007365	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
718255007366	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
718255007367	phosphopeptide binding site; other site
718255007368	Rhomboid family; Region: Rhomboid; pfam01694
718255007369	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
718255007370	SCP-2 sterol transfer family; Region: SCP2; pfam02036
718255007371	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
718255007372	HIT family signature motif; other site
718255007373	catalytic residue [active]
718255007374	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
718255007375	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
718255007376	active site
718255007377	homodimer interface [polypeptide binding]; other site
718255007378	Bacterial SH3 domain; Region: SH3_3; cl17532
718255007379	Bacterial SH3 domain; Region: SH3_3; pfam08239
718255007380	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
718255007381	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
718255007382	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
718255007383	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255007384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255007385	ATP binding site [chemical binding]; other site
718255007386	Mg2+ binding site [ion binding]; other site
718255007387	G-X-G motif; other site
718255007388	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718255007389	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718255007390	Walker A/P-loop; other site
718255007391	ATP binding site [chemical binding]; other site
718255007392	Q-loop/lid; other site
718255007393	ABC transporter signature motif; other site
718255007394	Walker B; other site
718255007395	D-loop; other site
718255007396	H-loop/switch region; other site
718255007397	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
718255007398	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255007399	motif II; other site
718255007400	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255007401	DNA binding site [nucleotide binding]
718255007402	Int/Topo IB signature motif; other site
718255007403	active site
718255007404	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
718255007405	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255007406	non-specific DNA binding site [nucleotide binding]; other site
718255007407	salt bridge; other site
718255007408	sequence-specific DNA binding site [nucleotide binding]; other site
718255007409	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255007410	salt bridge; other site
718255007411	non-specific DNA binding site [nucleotide binding]; other site
718255007412	sequence-specific DNA binding site [nucleotide binding]; other site
718255007413	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255007414	non-specific DNA binding site [nucleotide binding]; other site
718255007415	salt bridge; other site
718255007416	sequence-specific DNA binding site [nucleotide binding]; other site
718255007417	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255007418	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255007419	non-specific DNA binding site [nucleotide binding]; other site
718255007420	salt bridge; other site
718255007421	sequence-specific DNA binding site [nucleotide binding]; other site
718255007422	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
718255007423	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718255007424	Walker A motif; other site
718255007425	ATP binding site [chemical binding]; other site
718255007426	Walker B motif; other site
718255007427	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
718255007428	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
718255007429	Protein of unknown function (DUF497); Region: DUF497; pfam04365
718255007430	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
718255007431	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255007432	non-specific DNA binding site [nucleotide binding]; other site
718255007433	salt bridge; other site
718255007434	sequence-specific DNA binding site [nucleotide binding]; other site
718255007435	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
718255007436	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
718255007437	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
718255007438	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255007439	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
718255007440	Walker A motif; other site
718255007441	ATP binding site [chemical binding]; other site
718255007442	Walker B motif; other site
718255007443	arginine finger; other site
718255007444	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
718255007445	Replication initiation factor; Region: Rep_trans; pfam02486
718255007446	TcpE family; Region: TcpE; pfam12648
718255007447	AAA-like domain; Region: AAA_10; pfam12846
718255007448	Protein of unknown function, DUF624; Region: DUF624; cl02369
718255007449	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
718255007450	N-acetyl-D-glucosamine binding site [chemical binding]; other site
718255007451	catalytic residue [active]
718255007452	NlpC/P60 family; Region: NLPC_P60; pfam00877
718255007453	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
718255007454	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
718255007455	putative dimer interface [polypeptide binding]; other site
718255007456	catalytic triad [active]
718255007457	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
718255007458	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
718255007459	active site
718255007460	nucleophile elbow; other site
718255007461	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
718255007462	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
718255007463	putative ligand binding site [chemical binding]; other site
718255007464	putative NAD binding site [chemical binding]; other site
718255007465	catalytic site [active]
718255007466	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
718255007467	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
718255007468	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
718255007469	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
718255007470	ornithine carbamoyltransferase; Validated; Region: PRK02102
718255007471	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
718255007472	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
718255007473	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
718255007474	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718255007475	DNA-binding site [nucleotide binding]; DNA binding site
718255007476	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
718255007477	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
718255007478	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718255007479	nucleotide binding site [chemical binding]; other site
718255007480	Type III pantothenate kinase; Region: Pan_kinase; cl17198
718255007481	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
718255007482	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
718255007483	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
718255007484	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
718255007485	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
718255007486	dimer interface [polypeptide binding]; other site
718255007487	putative anticodon binding site; other site
718255007488	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
718255007489	motif 1; other site
718255007490	active site
718255007491	motif 2; other site
718255007492	motif 3; other site
718255007493	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
718255007494	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718255007495	P-loop; other site
718255007496	Magnesium ion binding site [ion binding]; other site
718255007497	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718255007498	Magnesium ion binding site [ion binding]; other site
718255007499	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
718255007500	ParB-like nuclease domain; Region: ParBc; pfam02195
718255007501	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
718255007502	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
718255007503	dimer interface [polypeptide binding]; other site
718255007504	putative tRNA-binding site [nucleotide binding]; other site
718255007505	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
718255007506	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255007507	putative catalytic residues [active]
718255007508	catalytic nucleophile [active]
718255007509	Recombinase; Region: Recombinase; pfam07508
718255007510	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255007511	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
718255007512	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
718255007513	Helix-turn-helix domain; Region: HTH_17; pfam12728
718255007514	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255007515	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255007516	active site
718255007517	phosphorylation site [posttranslational modification]
718255007518	intermolecular recognition site; other site
718255007519	dimerization interface [polypeptide binding]; other site
718255007520	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255007521	DNA binding site [nucleotide binding]
718255007522	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255007523	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255007524	dimer interface [polypeptide binding]; other site
718255007525	phosphorylation site [posttranslational modification]
718255007526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255007527	ATP binding site [chemical binding]; other site
718255007528	Mg2+ binding site [ion binding]; other site
718255007529	G-X-G motif; other site
718255007530	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
718255007531	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
718255007532	DNA binding residues [nucleotide binding]
718255007533	RNA polymerase sigma factor; Provisional; Region: PRK11924
718255007534	RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989
718255007535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
718255007536	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
718255007537	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
718255007538	hypothetical protein; Validated; Region: PRK08116
718255007539	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255007540	Walker A motif; other site
718255007541	ATP binding site [chemical binding]; other site
718255007542	Walker B motif; other site
718255007543	arginine finger; other site
718255007544	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
718255007545	Maff2 family; Region: Maff2; pfam12750
718255007546	YfkD-like protein; Region: YfkD; pfam14167
718255007547	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
718255007548	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
718255007549	hypothetical protein; Validated; Region: PRK08116
718255007550	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255007551	Walker A motif; other site
718255007552	ATP binding site [chemical binding]; other site
718255007553	Walker B motif; other site
718255007554	arginine finger; other site
718255007555	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
718255007556	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255007557	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
718255007558	putative catalytic residues [active]
718255007559	catalytic nucleophile [active]
718255007560	Recombinase; Region: Recombinase; pfam07508
718255007561	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255007562	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
718255007563	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
718255007564	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718255007565	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
718255007566	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
718255007567	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
718255007568	PhoU domain; Region: PhoU; pfam01895
718255007569	PhoU domain; Region: PhoU; pfam01895
718255007570	PBP superfamily domain; Region: PBP_like_2; cl17296
718255007571	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
718255007572	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
718255007573	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
718255007574	dimer interface [polypeptide binding]; other site
718255007575	ssDNA binding site [nucleotide binding]; other site
718255007576	tetramer (dimer of dimers) interface [polypeptide binding]; other site
718255007577	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
718255007578	non-specific DNA binding site [nucleotide binding]; other site
718255007579	salt bridge; other site
718255007580	sequence-specific DNA binding site [nucleotide binding]; other site
718255007581	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255007582	Coenzyme A binding pocket [chemical binding]; other site
718255007583	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
718255007584	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255007585	Coenzyme A binding pocket [chemical binding]; other site
718255007586	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
718255007587	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
718255007588	MobA/MobL family; Region: MobA_MobL; pfam03389
718255007589	Sec8 exocyst complex component specific domain; Region: Sec8_exocyst; pfam04048
718255007590	CHC2 zinc finger; Region: zf-CHC2; cl17510
718255007591	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
718255007592	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
718255007593	active site
718255007594	metal binding site [ion binding]; metal-binding site
718255007595	interdomain interaction site; other site
718255007596	AAA domain; Region: AAA_25; pfam13481
718255007597	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718255007598	ATP binding site [chemical binding]; other site
718255007599	Walker A motif; other site
718255007600	Walker B motif; other site
718255007601	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255007602	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
718255007603	putative catalytic residues [active]
718255007604	catalytic nucleophile [active]
718255007605	Recombinase; Region: Recombinase; pfam07508
718255007606	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255007607	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
718255007608	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
718255007609	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
718255007610	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
718255007611	active site
718255007612	metal binding site [ion binding]; metal-binding site
718255007613	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
718255007614	hypothetical protein; Validated; Region: PRK00124
718255007615	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
718255007616	putative ADP-ribose binding site [chemical binding]; other site
718255007617	putative active site [active]
718255007618	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
718255007619	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
718255007620	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
718255007621	putative active site [active]
718255007622	catalytic site [active]
718255007623	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
718255007624	putative active site [active]
718255007625	catalytic site [active]
718255007626	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
718255007627	dimer interface [polypeptide binding]; other site
718255007628	Citrate synthase; Region: Citrate_synt; pfam00285
718255007629	active site
718255007630	citrylCoA binding site [chemical binding]; other site
718255007631	oxalacetate/citrate binding site [chemical binding]; other site
718255007632	coenzyme A binding site [chemical binding]; other site
718255007633	catalytic triad [active]
718255007634	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255007635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255007636	active site
718255007637	phosphorylation site [posttranslational modification]
718255007638	intermolecular recognition site; other site
718255007639	dimerization interface [polypeptide binding]; other site
718255007640	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255007641	DNA binding site [nucleotide binding]
718255007642	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255007643	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255007644	ATP binding site [chemical binding]; other site
718255007645	G-X-G motif; other site
718255007646	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
718255007647	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
718255007648	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
718255007649	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
718255007650	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
718255007651	active site
718255007652	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
718255007653	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
718255007654	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255007655	Walker A motif; other site
718255007656	ATP binding site [chemical binding]; other site
718255007657	Walker B motif; other site
718255007658	arginine finger; other site
718255007659	Peptidase family M41; Region: Peptidase_M41; pfam01434
718255007660	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
718255007661	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
718255007662	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
718255007663	Walker A/P-loop; other site
718255007664	ATP binding site [chemical binding]; other site
718255007665	Q-loop/lid; other site
718255007666	ABC transporter signature motif; other site
718255007667	Walker B; other site
718255007668	D-loop; other site
718255007669	H-loop/switch region; other site
718255007670	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
718255007671	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
718255007672	lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733
718255007673	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
718255007674	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
718255007675	TIGR02677 family protein; Region: TIGR02677
718255007676	Protein of unknown function (DUF2398); Region: DUF2398; pfam09661
718255007677	TIGR02680 family protein; Region: TIGR02680
718255007678	P-loop containing region of AAA domain; Region: AAA_29; cl17516
718255007679	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
718255007680	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255007681	dimerization interface [polypeptide binding]; other site
718255007682	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255007683	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255007684	dimer interface [polypeptide binding]; other site
718255007685	putative CheW interface [polypeptide binding]; other site
718255007686	Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749
718255007687	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
718255007688	substrate binding site [chemical binding]; other site
718255007689	Peptidase family C69; Region: Peptidase_C69; pfam03577
718255007690	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
718255007691	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
718255007692	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
718255007693	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
718255007694	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718255007695	substrate binding site [chemical binding]; other site
718255007696	ATP binding site [chemical binding]; other site
718255007697	Uncharacterized conserved protein [Function unknown]; Region: COG1284
718255007698	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
718255007699	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
718255007700	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255007701	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255007702	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718255007703	dimerization interface [polypeptide binding]; other site
718255007704	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
718255007705	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
718255007706	Walker A/P-loop; other site
718255007707	ATP binding site [chemical binding]; other site
718255007708	Q-loop/lid; other site
718255007709	ABC transporter signature motif; other site
718255007710	Walker B; other site
718255007711	D-loop; other site
718255007712	H-loop/switch region; other site
718255007713	NIL domain; Region: NIL; pfam09383
718255007714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255007715	dimer interface [polypeptide binding]; other site
718255007716	conserved gate region; other site
718255007717	ABC-ATPase subunit interface; other site
718255007718	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
718255007719	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
718255007720	Inter-alpha-trypsin inhibitor heavy chain C-terminus; Region: ITI_HC_C; pfam06668
718255007721	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
718255007722	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
718255007723	Flagellin N-methylase; Region: FliB; pfam03692
718255007724	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
718255007725	LrgB-like family; Region: LrgB; pfam04172
718255007726	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718255007727	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
718255007728	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718255007729	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718255007730	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893
718255007731	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255007732	MFS/sugar transport protein; Region: MFS_2; pfam13347
718255007733	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718255007734	putative substrate translocation pore; other site
718255007735	Creatinine amidohydrolase; Region: Creatininase; cl00618
718255007736	Cupin domain; Region: Cupin_2; pfam07883
718255007737	Helix-turn-helix domain; Region: HTH_18; pfam12833
718255007738	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255007739	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
718255007740	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
718255007741	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
718255007742	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
718255007743	putative active site [active]
718255007744	putative metal binding site [ion binding]; other site
718255007745	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
718255007746	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
718255007747	NAD binding site [chemical binding]; other site
718255007748	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
718255007749	TSCPD domain; Region: TSCPD; cl14834
718255007750	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
718255007751	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
718255007752	ATP binding site [chemical binding]; other site
718255007753	putative Mg++ binding site [ion binding]; other site
718255007754	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
718255007755	SEC-C motif; Region: SEC-C; pfam02810
718255007756	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
718255007757	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
718255007758	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
718255007759	excinuclease ABC subunit B; Provisional; Region: PRK05298
718255007760	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718255007761	ATP binding site [chemical binding]; other site
718255007762	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718255007763	nucleotide binding region [chemical binding]; other site
718255007764	ATP-binding site [chemical binding]; other site
718255007765	Ultra-violet resistance protein B; Region: UvrB; pfam12344
718255007766	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
718255007767	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
718255007768	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
718255007769	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
718255007770	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
718255007771	Acyltransferase family; Region: Acyl_transf_3; pfam01757
718255007772	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
718255007773	Acyltransferase family; Region: Acyl_transf_3; pfam01757
718255007774	rod shape-determining protein Mbl; Provisional; Region: PRK13928
718255007775	MreB and similar proteins; Region: MreB_like; cd10225
718255007776	nucleotide binding site [chemical binding]; other site
718255007777	Mg binding site [ion binding]; other site
718255007778	putative protofilament interaction site [polypeptide binding]; other site
718255007779	RodZ interaction site [polypeptide binding]; other site
718255007780	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818
718255007781	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
718255007782	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
718255007783	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
718255007784	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
718255007785	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
718255007786	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
718255007787	AAA domain; Region: AAA_30; pfam13604
718255007788	Family description; Region: UvrD_C_2; pfam13538
718255007789	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
718255007790	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255007791	Walker A/P-loop; other site
718255007792	ATP binding site [chemical binding]; other site
718255007793	Q-loop/lid; other site
718255007794	ABC transporter signature motif; other site
718255007795	Walker B; other site
718255007796	D-loop; other site
718255007797	H-loop/switch region; other site
718255007798	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718255007799	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
718255007800	TM-ABC transporter signature motif; other site
718255007801	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
718255007802	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
718255007803	zinc binding site [ion binding]; other site
718255007804	putative ligand binding site [chemical binding]; other site
718255007805	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
718255007806	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718255007807	active site
718255007808	flagellar operon protein TIGR03826; Region: YvyF
718255007809	YibE/F-like protein; Region: YibE_F; cl02259
718255007810	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
718255007811	YbbR-like protein; Region: YbbR; pfam07949
718255007812	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
718255007813	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
718255007814	active site
718255007815	substrate binding site [chemical binding]; other site
718255007816	metal binding site [ion binding]; metal-binding site
718255007817	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718255007818	dimerization domain swap beta strand [polypeptide binding]; other site
718255007819	regulatory protein interface [polypeptide binding]; other site
718255007820	active site
718255007821	regulatory phosphorylation site [posttranslational modification]; other site
718255007822	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
718255007823	NADP binding site [chemical binding]; other site
718255007824	active site
718255007825	putative substrate binding site [chemical binding]; other site
718255007826	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718255007827	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
718255007828	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
718255007829	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
718255007830	NAD binding site [chemical binding]; other site
718255007831	substrate binding site [chemical binding]; other site
718255007832	homodimer interface [polypeptide binding]; other site
718255007833	active site
718255007834	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
718255007835	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
718255007836	substrate binding site; other site
718255007837	tetramer interface; other site
718255007838	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
718255007839	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
718255007840	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
718255007841	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
718255007842	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
718255007843	Walker A/P-loop; other site
718255007844	ATP binding site [chemical binding]; other site
718255007845	Q-loop/lid; other site
718255007846	ABC transporter signature motif; other site
718255007847	Walker B; other site
718255007848	D-loop; other site
718255007849	H-loop/switch region; other site
718255007850	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
718255007851	putative carbohydrate binding site [chemical binding]; other site
718255007852	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
718255007853	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
718255007854	Bacterial sugar transferase; Region: Bac_transf; pfam02397
718255007855	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
718255007856	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
718255007857	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
718255007858	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
718255007859	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
718255007860	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
718255007861	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
718255007862	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
718255007863	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718255007864	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
718255007865	NAD(P) binding site [chemical binding]; other site
718255007866	active site
718255007867	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
718255007868	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718255007869	active site
718255007870	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718255007871	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
718255007872	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
718255007873	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255007874	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
718255007875	Bacterial sugar transferase; Region: Bac_transf; pfam02397
718255007876	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
718255007877	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
718255007878	active site
718255007879	metal binding site [ion binding]; metal-binding site
718255007880	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255007881	Interdomain contacts; other site
718255007882	Cytokine receptor motif; other site
718255007883	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255007884	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
718255007885	Interdomain contacts; other site
718255007886	Cytokine receptor motif; other site
718255007887	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255007888	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255007889	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
718255007890	Interdomain contacts; other site
718255007891	Cytokine receptor motif; other site
718255007892	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718255007893	active site
718255007894	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718255007895	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
718255007896	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
718255007897	YacP-like NYN domain; Region: NYN_YacP; cl01491
718255007898	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
718255007899	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
718255007900	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
718255007901	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
718255007902	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
718255007903	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
718255007904	Walker A/P-loop; other site
718255007905	ATP binding site [chemical binding]; other site
718255007906	Q-loop/lid; other site
718255007907	ABC transporter signature motif; other site
718255007908	Walker B; other site
718255007909	D-loop; other site
718255007910	H-loop/switch region; other site
718255007911	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
718255007912	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718255007913	NAD(P) binding site [chemical binding]; other site
718255007914	active site
718255007915	Right handed beta helix region; Region: Beta_helix; pfam13229
718255007916	Right handed beta helix region; Region: Beta_helix; pfam13229
718255007917	Right handed beta helix region; Region: Beta_helix; pfam13229
718255007918	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
718255007919	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
718255007920	NAD(P) binding site [chemical binding]; other site
718255007921	homodimer interface [polypeptide binding]; other site
718255007922	substrate binding site [chemical binding]; other site
718255007923	active site
718255007924	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
718255007925	AAA domain; Region: AAA_21; pfam13304
718255007926	AAA domain; Region: AAA_21; pfam13304
718255007927	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255007928	Walker B; other site
718255007929	D-loop; other site
718255007930	H-loop/switch region; other site
718255007931	Bacterial sugar transferase; Region: Bac_transf; pfam02397
718255007932	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
718255007933	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718255007934	NAD(P) binding site [chemical binding]; other site
718255007935	active site
718255007936	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
718255007937	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
718255007938	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
718255007939	active site
718255007940	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718255007941	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
718255007942	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
718255007943	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
718255007944	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
718255007945	Walker A/P-loop; other site
718255007946	ATP binding site [chemical binding]; other site
718255007947	Q-loop/lid; other site
718255007948	ABC transporter signature motif; other site
718255007949	Walker B; other site
718255007950	D-loop; other site
718255007951	H-loop/switch region; other site
718255007952	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
718255007953	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
718255007954	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
718255007955	Ligand binding site; other site
718255007956	metal-binding site
718255007957	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
718255007958	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
718255007959	UDP-galactopyranose mutase; Region: GLF; pfam03275
718255007960	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
718255007961	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
718255007962	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
718255007963	Ligand binding site; other site
718255007964	metal-binding site
718255007965	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
718255007966	Acyltransferase family; Region: Acyl_transf_3; pfam01757
718255007967	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255007968	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
718255007969	active site
718255007970	motif I; other site
718255007971	motif II; other site
718255007972	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718255007973	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255007974	DNA binding residues [nucleotide binding]
718255007975	Recombinase; Region: Recombinase; pfam07508
718255007976	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255007977	Zn2+ binding site [ion binding]; other site
718255007978	Mg2+ binding site [ion binding]; other site
718255007979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255007980	ATP binding site [chemical binding]; other site
718255007981	Mg2+ binding site [ion binding]; other site
718255007982	G-X-G motif; other site
718255007983	putative transposase OrfB; Reviewed; Region: PHA02517
718255007984	HTH-like domain; Region: HTH_21; pfam13276
718255007985	Integrase core domain; Region: rve; pfam00665
718255007986	Integrase core domain; Region: rve_3; pfam13683
718255007987	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
718255007988	Helix-turn-helix domain; Region: HTH_28; pfam13518
718255007989	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
718255007990	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718255007991	P-loop; other site
718255007992	Magnesium ion binding site [ion binding]; other site
718255007993	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718255007994	Magnesium ion binding site [ion binding]; other site
718255007995	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
718255007996	ParB-like nuclease domain; Region: ParB; smart00470
718255007997	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
718255007998	MT-A70; Region: MT-A70; cl01947
718255007999	MT-A70; Region: MT-A70; cl01947
718255008000	PrgI family protein; Region: PrgI; pfam12666
718255008001	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
718255008002	L-rhamnose isomerase; Provisional; Region: PRK01076
718255008003	Cupin domain; Region: Cupin_2; pfam07883
718255008004	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718255008005	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255008006	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
718255008007	putative hydrolase; Provisional; Region: PRK11460
718255008008	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
718255008009	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255008010	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255008011	MFS/sugar transport protein; Region: MFS_2; pfam13347
718255008012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718255008013	putative substrate translocation pore; other site
718255008014	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
718255008015	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
718255008016	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
718255008017	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
718255008018	active site
718255008019	catalytic triad [active]
718255008020	oxyanion hole [active]
718255008021	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
718255008022	MFS/sugar transport protein; Region: MFS_2; pfam13347
718255008023	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
718255008024	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255008025	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255008026	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
718255008027	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
718255008028	phosphate binding site [ion binding]; other site
718255008029	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718255008030	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
718255008031	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718255008032	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718255008033	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
718255008034	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
718255008035	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255008036	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
718255008037	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255008038	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255008039	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718255008040	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
718255008041	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
718255008042	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718255008043	transcriptional repressor DicA; Reviewed; Region: PRK09706
718255008044	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255008045	non-specific DNA binding site [nucleotide binding]; other site
718255008046	salt bridge; other site
718255008047	sequence-specific DNA binding site [nucleotide binding]; other site
718255008048	ORF6N domain; Region: ORF6N; pfam10543
718255008049	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
718255008050	ArsC family; Region: ArsC; pfam03960
718255008051	putative ArsC-like catalytic residues; other site
718255008052	putative TRX-like catalytic residues [active]
718255008053	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
718255008054	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
718255008055	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
718255008056	trimer interface [polypeptide binding]; other site
718255008057	putative metal binding site [ion binding]; other site
718255008058	PAS fold; Region: PAS_3; pfam08447
718255008059	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255008060	metal binding site [ion binding]; metal-binding site
718255008061	active site
718255008062	I-site; other site
718255008063	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718255008064	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
718255008065	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
718255008066	homodimer interface [polypeptide binding]; other site
718255008067	substrate-cofactor binding pocket; other site
718255008068	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255008069	catalytic residue [active]
718255008070	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
718255008071	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
718255008072	Sulfate transporter family; Region: Sulfate_transp; pfam00916
718255008073	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
718255008074	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255008075	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255008076	non-specific DNA binding site [nucleotide binding]; other site
718255008077	salt bridge; other site
718255008078	sequence-specific DNA binding site [nucleotide binding]; other site
718255008079	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
718255008080	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
718255008081	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
718255008082	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
718255008083	Rhomboid family; Region: Rhomboid; pfam01694
718255008084	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
718255008085	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
718255008086	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
718255008087	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
718255008088	putative metal binding site [ion binding]; other site
718255008089	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
718255008090	Tellurium resistance protein; Region: Tellurium_res; pfam10138
718255008091	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
718255008092	putative metal binding site [ion binding]; other site
718255008093	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
718255008094	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
718255008095	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718255008096	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
718255008097	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255008098	motif II; other site
718255008099	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
718255008100	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
718255008101	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
718255008102	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
718255008103	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
718255008104	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
718255008105	putative metal binding site [ion binding]; other site
718255008106	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718255008107	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
718255008108	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718255008109	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
718255008110	enolase; Provisional; Region: eno; PRK00077
718255008111	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
718255008112	dimer interface [polypeptide binding]; other site
718255008113	metal binding site [ion binding]; metal-binding site
718255008114	substrate binding pocket [chemical binding]; other site
718255008115	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
718255008116	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718255008117	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718255008118	Walker A/P-loop; other site
718255008119	ATP binding site [chemical binding]; other site
718255008120	Q-loop/lid; other site
718255008121	ABC transporter signature motif; other site
718255008122	Walker B; other site
718255008123	D-loop; other site
718255008124	H-loop/switch region; other site
718255008125	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718255008126	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
718255008127	PspA/IM30 family; Region: PspA_IM30; pfam04012
718255008128	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
718255008129	FtsX-like permease family; Region: FtsX; pfam02687
718255008130	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718255008131	FtsX-like permease family; Region: FtsX; pfam02687
718255008132	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
718255008133	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
718255008134	active site
718255008135	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u1; cd12826
718255008136	Cl binding site [ion binding]; other site
718255008137	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
718255008138	oligomer interface [polypeptide binding]; other site
718255008139	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
718255008140	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
718255008141	Walker A/P-loop; other site
718255008142	ATP binding site [chemical binding]; other site
718255008143	Q-loop/lid; other site
718255008144	ABC transporter signature motif; other site
718255008145	Walker B; other site
718255008146	D-loop; other site
718255008147	H-loop/switch region; other site
718255008148	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
718255008149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255008150	dimer interface [polypeptide binding]; other site
718255008151	conserved gate region; other site
718255008152	putative PBP binding loops; other site
718255008153	ABC-ATPase subunit interface; other site
718255008154	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
718255008155	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
718255008156	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
718255008157	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
718255008158	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
718255008159	trimer interface [polypeptide binding]; other site
718255008160	active site
718255008161	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
718255008162	catalytic site [active]
718255008163	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718255008164	dimerization domain swap beta strand [polypeptide binding]; other site
718255008165	regulatory protein interface [polypeptide binding]; other site
718255008166	active site
718255008167	regulatory phosphorylation site [posttranslational modification]; other site
718255008168	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
718255008169	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
718255008170	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718255008171	active site
718255008172	DNA replication protein DnaC; Validated; Region: PRK06835
718255008173	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255008174	Walker A motif; other site
718255008175	ATP binding site [chemical binding]; other site
718255008176	Walker B motif; other site
718255008177	arginine finger; other site
718255008178	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
718255008179	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
718255008180	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
718255008181	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
718255008182	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718255008183	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718255008184	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
718255008185	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
718255008186	ligand binding site; other site
718255008187	oligomer interface; other site
718255008188	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
718255008189	dimer interface [polypeptide binding]; other site
718255008190	N-terminal domain interface [polypeptide binding]; other site
718255008191	sulfate 1 binding site; other site
718255008192	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
718255008193	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
718255008194	ligand binding site; other site
718255008195	oligomer interface; other site
718255008196	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
718255008197	dimer interface [polypeptide binding]; other site
718255008198	N-terminal domain interface [polypeptide binding]; other site
718255008199	regulatory protein SpoVG; Reviewed; Region: PRK13259
718255008200	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
718255008201	Substrate binding site; other site
718255008202	Mg++ binding site; other site
718255008203	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
718255008204	putative active site [active]
718255008205	catalytic residue [active]
718255008206	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
718255008207	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
718255008208	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
718255008209	shikimate kinase; Reviewed; Region: aroK; PRK00131
718255008210	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
718255008211	ADP binding site [chemical binding]; other site
718255008212	magnesium binding site [ion binding]; other site
718255008213	putative shikimate binding site; other site
718255008214	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
718255008215	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718255008216	G5 domain; Region: G5; pfam07501
718255008217	Peptidase family M23; Region: Peptidase_M23; pfam01551
718255008218	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
718255008219	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
718255008220	hinge; other site
718255008221	active site
718255008222	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
718255008223	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
718255008224	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255008225	Zn2+ binding site [ion binding]; other site
718255008226	Mg2+ binding site [ion binding]; other site
718255008227	S-adenosylmethionine synthetase; Validated; Region: PRK05250
718255008228	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
718255008229	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
718255008230	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
718255008231	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255008232	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255008233	dimerization interface [polypeptide binding]; other site
718255008234	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255008235	dimer interface [polypeptide binding]; other site
718255008236	phosphorylation site [posttranslational modification]
718255008237	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255008238	ATP binding site [chemical binding]; other site
718255008239	Mg2+ binding site [ion binding]; other site
718255008240	G-X-G motif; other site
718255008241	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255008242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255008243	active site
718255008244	phosphorylation site [posttranslational modification]
718255008245	intermolecular recognition site; other site
718255008246	dimerization interface [polypeptide binding]; other site
718255008247	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255008248	DNA binding site [nucleotide binding]
718255008249	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
718255008250	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
718255008251	active site
718255008252	prolyl-tRNA synthetase; Provisional; Region: PRK08661
718255008253	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
718255008254	dimer interface [polypeptide binding]; other site
718255008255	motif 1; other site
718255008256	active site
718255008257	motif 2; other site
718255008258	motif 3; other site
718255008259	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
718255008260	anticodon binding site; other site
718255008261	zinc-binding site [ion binding]; other site
718255008262	Tetratricopeptide repeat; Region: TPR_12; pfam13424
718255008263	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255008264	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255008265	metal binding site [ion binding]; metal-binding site
718255008266	active site
718255008267	I-site; other site
718255008268	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
718255008269	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
718255008270	active site
718255008271	NTP binding site [chemical binding]; other site
718255008272	metal binding triad [ion binding]; metal-binding site
718255008273	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
718255008274	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255008275	Zn2+ binding site [ion binding]; other site
718255008276	Mg2+ binding site [ion binding]; other site
718255008277	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
718255008278	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
718255008279	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
718255008280	active site
718255008281	ATP binding site [chemical binding]; other site
718255008282	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
718255008283	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
718255008284	active site
718255008285	substrate binding site [chemical binding]; other site
718255008286	metal binding site [ion binding]; metal-binding site
718255008287	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
718255008288	IHF dimer interface [polypeptide binding]; other site
718255008289	IHF - DNA interface [nucleotide binding]; other site
718255008290	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718255008291	RNA binding surface [nucleotide binding]; other site
718255008292	YabP family; Region: YabP; cl06766
718255008293	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578
718255008294	Septum formation initiator; Region: DivIC; cl17659
718255008295	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718255008296	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
718255008297	active site
718255008298	catalytic tetrad [active]
718255008299	stage II sporulation protein E; Region: spore_II_E; TIGR02865
718255008300	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
718255008301	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
718255008302	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
718255008303	Ligand Binding Site [chemical binding]; other site
718255008304	TilS substrate C-terminal domain; Region: TilS_C; smart00977
718255008305	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
718255008306	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718255008307	membrane-bound complex binding site; other site
718255008308	hinge residues; other site
718255008309	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
718255008310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255008311	dimer interface [polypeptide binding]; other site
718255008312	conserved gate region; other site
718255008313	putative PBP binding loops; other site
718255008314	ABC-ATPase subunit interface; other site
718255008315	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
718255008316	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255008317	dimer interface [polypeptide binding]; other site
718255008318	conserved gate region; other site
718255008319	putative PBP binding loops; other site
718255008320	ABC-ATPase subunit interface; other site
718255008321	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
718255008322	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255008323	Walker A/P-loop; other site
718255008324	ATP binding site [chemical binding]; other site
718255008325	Q-loop/lid; other site
718255008326	ABC transporter signature motif; other site
718255008327	Walker B; other site
718255008328	D-loop; other site
718255008329	H-loop/switch region; other site
718255008330	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
718255008331	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
718255008332	Active Sites [active]
718255008333	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
718255008334	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
718255008335	CysD dimerization site [polypeptide binding]; other site
718255008336	G1 box; other site
718255008337	putative GEF interaction site [polypeptide binding]; other site
718255008338	GTP/Mg2+ binding site [chemical binding]; other site
718255008339	Switch I region; other site
718255008340	G2 box; other site
718255008341	G3 box; other site
718255008342	Switch II region; other site
718255008343	G4 box; other site
718255008344	G5 box; other site
718255008345	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
718255008346	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
718255008347	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
718255008348	homodimer interface [polypeptide binding]; other site
718255008349	maltodextrin glucosidase; Provisional; Region: PRK10785
718255008350	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
718255008351	active site
718255008352	homodimer interface [polypeptide binding]; other site
718255008353	catalytic site [active]
718255008354	HAMP domain; Region: HAMP; pfam00672
718255008355	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255008356	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255008357	dimer interface [polypeptide binding]; other site
718255008358	putative CheW interface [polypeptide binding]; other site
718255008359	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
718255008360	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718255008361	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718255008362	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
718255008363	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
718255008364	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255008365	motif II; other site
718255008366	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
718255008367	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
718255008368	putative deacylase active site [active]
718255008369	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
718255008370	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255008371	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255008372	metal binding site [ion binding]; metal-binding site
718255008373	active site
718255008374	I-site; other site
718255008375	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
718255008376	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255008377	Zn2+ binding site [ion binding]; other site
718255008378	Mg2+ binding site [ion binding]; other site
718255008379	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
718255008380	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255008381	Zn2+ binding site [ion binding]; other site
718255008382	Mg2+ binding site [ion binding]; other site
718255008383	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
718255008384	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
718255008385	Predicted membrane protein [Function unknown]; Region: COG1971
718255008386	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
718255008387	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
718255008388	active site
718255008389	catalytic site [active]
718255008390	substrate binding site [chemical binding]; other site
718255008391	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
718255008392	VanW like protein; Region: VanW; pfam04294
718255008393	G5 domain; Region: G5; pfam07501
718255008394	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
718255008395	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
718255008396	dimerization interface [polypeptide binding]; other site
718255008397	putative ATP binding site [chemical binding]; other site
718255008398	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
718255008399	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
718255008400	AsnC family; Region: AsnC_trans_reg; pfam01037
718255008401	hypothetical protein; Validated; Region: PRK07682
718255008402	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718255008403	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255008404	homodimer interface [polypeptide binding]; other site
718255008405	catalytic residue [active]
718255008406	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
718255008407	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
718255008408	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
718255008409	Walker A/P-loop; other site
718255008410	ATP binding site [chemical binding]; other site
718255008411	Q-loop/lid; other site
718255008412	ABC transporter signature motif; other site
718255008413	Walker B; other site
718255008414	D-loop; other site
718255008415	H-loop/switch region; other site
718255008416	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
718255008417	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
718255008418	Walker A/P-loop; other site
718255008419	ATP binding site [chemical binding]; other site
718255008420	Q-loop/lid; other site
718255008421	ABC transporter signature motif; other site
718255008422	Walker B; other site
718255008423	D-loop; other site
718255008424	H-loop/switch region; other site
718255008425	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
718255008426	Helix-turn-helix domain; Region: HTH_31; pfam13560
718255008427	non-specific DNA binding site [nucleotide binding]; other site
718255008428	salt bridge; other site
718255008429	sequence-specific DNA binding site [nucleotide binding]; other site
718255008430	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
718255008431	Catalytic domain of Protein Kinases; Region: PKc; cd00180
718255008432	active site
718255008433	ATP binding site [chemical binding]; other site
718255008434	substrate binding site [chemical binding]; other site
718255008435	activation loop (A-loop); other site
718255008436	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
718255008437	Double zinc ribbon; Region: DZR; pfam12773
718255008438	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
718255008439	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
718255008440	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
718255008441	23S rRNA interface [nucleotide binding]; other site
718255008442	L3 interface [polypeptide binding]; other site
718255008443	Divergent AAA domain; Region: AAA_4; pfam04326
718255008444	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
718255008445	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
718255008446	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255008447	non-specific DNA binding site [nucleotide binding]; other site
718255008448	salt bridge; other site
718255008449	sequence-specific DNA binding site [nucleotide binding]; other site
718255008450	Helix-turn-helix domain; Region: HTH_17; pfam12728
718255008451	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255008452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255008453	active site
718255008454	phosphorylation site [posttranslational modification]
718255008455	intermolecular recognition site; other site
718255008456	dimerization interface [polypeptide binding]; other site
718255008457	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255008458	DNA binding site [nucleotide binding]
718255008459	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255008460	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255008461	dimer interface [polypeptide binding]; other site
718255008462	phosphorylation site [posttranslational modification]
718255008463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255008464	ATP binding site [chemical binding]; other site
718255008465	Mg2+ binding site [ion binding]; other site
718255008466	G-X-G motif; other site
718255008467	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718255008468	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718255008469	Walker A/P-loop; other site
718255008470	ATP binding site [chemical binding]; other site
718255008471	Q-loop/lid; other site
718255008472	ABC transporter signature motif; other site
718255008473	Walker B; other site
718255008474	D-loop; other site
718255008475	H-loop/switch region; other site
718255008476	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718255008477	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718255008478	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
718255008479	FtsX-like permease family; Region: FtsX; pfam02687
718255008480	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
718255008481	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
718255008482	putative active site [active]
718255008483	putative NTP binding site [chemical binding]; other site
718255008484	putative nucleic acid binding site [nucleotide binding]; other site
718255008485	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
718255008486	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718255008487	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255008488	DNA binding residues [nucleotide binding]
718255008489	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
718255008490	HsdM N-terminal domain; Region: HsdM_N; pfam12161
718255008491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255008492	S-adenosylmethionine binding site [chemical binding]; other site
718255008493	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
718255008494	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
718255008495	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
718255008496	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
718255008497	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
718255008498	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718255008499	ATP binding site [chemical binding]; other site
718255008500	putative Mg++ binding site [ion binding]; other site
718255008501	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
718255008502	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718255008503	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255008504	DNA binding residues [nucleotide binding]
718255008505	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255008506	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255008507	dimer interface [polypeptide binding]; other site
718255008508	phosphorylation site [posttranslational modification]
718255008509	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255008510	ATP binding site [chemical binding]; other site
718255008511	Mg2+ binding site [ion binding]; other site
718255008512	G-X-G motif; other site
718255008513	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718255008514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255008515	active site
718255008516	phosphorylation site [posttranslational modification]
718255008517	intermolecular recognition site; other site
718255008518	dimerization interface [polypeptide binding]; other site
718255008519	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718255008520	DNA binding site [nucleotide binding]
718255008521	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
718255008522	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
718255008523	Walker A/P-loop; other site
718255008524	ATP binding site [chemical binding]; other site
718255008525	Q-loop/lid; other site
718255008526	ABC transporter signature motif; other site
718255008527	Walker B; other site
718255008528	D-loop; other site
718255008529	H-loop/switch region; other site
718255008530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
718255008531	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
718255008532	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
718255008533	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
718255008534	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
718255008535	putative phosphoketolase; Provisional; Region: PRK05261
718255008536	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
718255008537	TPP-binding site; other site
718255008538	XFP C-terminal domain; Region: XFP_C; pfam09363
718255008539	Cupin domain; Region: Cupin_2; pfam07883
718255008540	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255008541	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255008542	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255008543	dimer interface [polypeptide binding]; other site
718255008544	putative CheW interface [polypeptide binding]; other site
718255008545	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
718255008546	ATP binding site [chemical binding]; other site
718255008547	Mg2+ binding site [ion binding]; other site
718255008548	G-X-G motif; other site
718255008549	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255008550	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
718255008551	Walker A/P-loop; other site
718255008552	ATP binding site [chemical binding]; other site
718255008553	Q-loop/lid; other site
718255008554	ABC transporter signature motif; other site
718255008555	Walker B; other site
718255008556	D-loop; other site
718255008557	H-loop/switch region; other site
718255008558	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255008559	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
718255008560	Walker A/P-loop; other site
718255008561	ATP binding site [chemical binding]; other site
718255008562	Q-loop/lid; other site
718255008563	ABC transporter signature motif; other site
718255008564	Walker B; other site
718255008565	D-loop; other site
718255008566	H-loop/switch region; other site
718255008567	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255008568	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255008569	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255008570	Interdomain contacts; other site
718255008571	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255008572	Interdomain contacts; other site
718255008573	Cytokine receptor motif; other site
718255008574	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255008575	Interdomain contacts; other site
718255008576	Cytokine receptor motif; other site
718255008577	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255008578	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
718255008579	Interdomain contacts; other site
718255008580	Cytokine receptor motif; other site
718255008581	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255008582	Interdomain contacts; other site
718255008583	Cytokine receptor motif; other site
718255008584	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
718255008585	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
718255008586	active site
718255008587	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
718255008588	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
718255008589	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
718255008590	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
718255008591	substrate binding site [chemical binding]; other site
718255008592	active site
718255008593	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
718255008594	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
718255008595	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
718255008596	active site
718255008597	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
718255008598	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
718255008599	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
718255008600	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
718255008601	active site
718255008602	metal binding site [ion binding]; metal-binding site
718255008603	homotetramer interface [polypeptide binding]; other site
718255008604	PAS domain; Region: PAS_9; pfam13426
718255008605	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
718255008606	putative active site [active]
718255008607	heme pocket [chemical binding]; other site
718255008608	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255008609	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255008610	metal binding site [ion binding]; metal-binding site
718255008611	active site
718255008612	I-site; other site
718255008613	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
718255008614	Pyruvate formate lyase 1; Region: PFL1; cd01678
718255008615	coenzyme A binding site [chemical binding]; other site
718255008616	active site
718255008617	catalytic residues [active]
718255008618	glycine loop; other site
718255008619	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
718255008620	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255008621	FeS/SAM binding site; other site
718255008622	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
718255008623	30S subunit binding site; other site
718255008624	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
718255008625	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
718255008626	ATP-grasp domain; Region: ATP-grasp_4; cl17255
718255008627	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
718255008628	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
718255008629	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718255008630	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718255008631	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
718255008632	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
718255008633	putative acyl-acceptor binding pocket; other site
718255008634	PrcB C-terminal; Region: PrcB_C; pfam14343
718255008635	Protein of unknown function (DUF1021); Region: DUF1021; cl01852
718255008636	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
718255008637	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
718255008638	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
718255008639	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
718255008640	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718255008641	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
718255008642	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718255008643	NlpC/P60 family; Region: NLPC_P60; pfam00877
718255008644	Yqey-like protein; Region: YqeY; cl17540
718255008645	methionine aminopeptidase; Provisional; Region: PRK12318
718255008646	SEC-C motif; Region: SEC-C; pfam02810
718255008647	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
718255008648	active site
718255008649	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
718255008650	monogalactosyldiacylglycerol synthase; Region: PLN02605
718255008651	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
718255008652	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
718255008653	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255008654	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255008655	DNA binding site [nucleotide binding]
718255008656	domain linker motif; other site
718255008657	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
718255008658	ligand binding site [chemical binding]; other site
718255008659	dimerization interface [polypeptide binding]; other site
718255008660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
718255008661	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
718255008662	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255008663	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718255008664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255008665	dimer interface [polypeptide binding]; other site
718255008666	conserved gate region; other site
718255008667	putative PBP binding loops; other site
718255008668	ABC-ATPase subunit interface; other site
718255008669	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255008670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255008671	dimer interface [polypeptide binding]; other site
718255008672	conserved gate region; other site
718255008673	putative PBP binding loops; other site
718255008674	ABC-ATPase subunit interface; other site
718255008675	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
718255008676	Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891
718255008677	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
718255008678	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
718255008679	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718255008680	myosin-cross-reactive antigen; Provisional; Region: PRK13977
718255008681	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255008682	Coenzyme A binding pocket [chemical binding]; other site
718255008683	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
718255008684	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
718255008685	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
718255008686	shikimate binding site; other site
718255008687	NAD(P) binding site [chemical binding]; other site
718255008688	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
718255008689	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
718255008690	active site
718255008691	FMN binding site [chemical binding]; other site
718255008692	substrate binding site [chemical binding]; other site
718255008693	putative catalytic residue [active]
718255008694	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
718255008695	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
718255008696	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718255008697	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255008698	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255008699	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
718255008700	putative dimerization interface [polypeptide binding]; other site
718255008701	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255008702	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255008703	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718255008704	dimerization interface [polypeptide binding]; other site
718255008705	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
718255008706	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
718255008707	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
718255008708	shikimate binding site; other site
718255008709	NAD(P) binding site [chemical binding]; other site
718255008710	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718255008711	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
718255008712	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
718255008713	active site
718255008714	catalytic residue [active]
718255008715	dimer interface [polypeptide binding]; other site
718255008716	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
718255008717	DctM-like transporters; Region: DctM; pfam06808
718255008718	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
718255008719	Chorismate mutase type II; Region: CM_2; cl00693
718255008720	shikimate kinase; Reviewed; Region: aroK; PRK00131
718255008721	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
718255008722	ADP binding site [chemical binding]; other site
718255008723	magnesium binding site [ion binding]; other site
718255008724	putative shikimate binding site; other site
718255008725	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
718255008726	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
718255008727	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
718255008728	Beta-lactamase; Region: Beta-lactamase; pfam00144
718255008729	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
718255008730	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
718255008731	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
718255008732	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
718255008733	LytTr DNA-binding domain; Region: LytTR; smart00850
718255008734	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
718255008735	Protein of unknown function (DUF975); Region: DUF975; cl10504
718255008736	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
718255008737	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
718255008738	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
718255008739	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
718255008740	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
718255008741	RNA binding site [nucleotide binding]; other site
718255008742	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
718255008743	Predicted membrane protein [Function unknown]; Region: COG3601
718255008744	YcxB-like protein; Region: YcxB; pfam14317
718255008745	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
718255008746	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
718255008747	Glycoprotease family; Region: Peptidase_M22; pfam00814
718255008748	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
718255008749	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255008750	Coenzyme A binding pocket [chemical binding]; other site
718255008751	ribonuclease Z; Reviewed; Region: PRK00055
718255008752	UGMP family protein; Validated; Region: PRK09604
718255008753	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
718255008754	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
718255008755	substrate binding site; other site
718255008756	dimer interface; other site
718255008757	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255008758	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255008759	non-specific DNA binding site [nucleotide binding]; other site
718255008760	salt bridge; other site
718255008761	sequence-specific DNA binding site [nucleotide binding]; other site
718255008762	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255008763	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
718255008764	catalytic residues [active]
718255008765	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255008766	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255008767	non-specific DNA binding site [nucleotide binding]; other site
718255008768	salt bridge; other site
718255008769	sequence-specific DNA binding site [nucleotide binding]; other site
718255008770	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718255008771	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
718255008772	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
718255008773	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
718255008774	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255008775	active site
718255008776	DNA binding site [nucleotide binding]
718255008777	Int/Topo IB signature motif; other site
718255008778	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
718255008779	Low molecular weight phosphatase family; Region: LMWPc; cl00105
718255008780	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
718255008781	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
718255008782	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
718255008783	active site
718255008784	homodimer interface [polypeptide binding]; other site
718255008785	catalytic site [active]
718255008786	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
718255008787	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
718255008788	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
718255008789	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
718255008790	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
718255008791	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
718255008792	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
718255008793	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
718255008794	Dimer interface [polypeptide binding]; other site
718255008795	anticodon binding site; other site
718255008796	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
718255008797	motif 1; other site
718255008798	dimer interface [polypeptide binding]; other site
718255008799	active site
718255008800	motif 2; other site
718255008801	motif 3; other site
718255008802	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
718255008803	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
718255008804	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
718255008805	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
718255008806	GatB domain; Region: GatB_Yqey; smart00845
718255008807	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255008808	Zn2+ binding site [ion binding]; other site
718255008809	Mg2+ binding site [ion binding]; other site
718255008810	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255008811	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255008812	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
718255008813	Walker A/P-loop; other site
718255008814	ATP binding site [chemical binding]; other site
718255008815	Q-loop/lid; other site
718255008816	ABC transporter signature motif; other site
718255008817	Walker B; other site
718255008818	D-loop; other site
718255008819	H-loop/switch region; other site
718255008820	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718255008821	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718255008822	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255008823	Walker A/P-loop; other site
718255008824	ATP binding site [chemical binding]; other site
718255008825	Q-loop/lid; other site
718255008826	ABC transporter signature motif; other site
718255008827	Walker B; other site
718255008828	D-loop; other site
718255008829	H-loop/switch region; other site
718255008830	Transcriptional regulators [Transcription]; Region: MarR; COG1846
718255008831	MarR family; Region: MarR_2; pfam12802
718255008832	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
718255008833	ATP cone domain; Region: ATP-cone; pfam03477
718255008834	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
718255008835	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
718255008836	active site 1 [active]
718255008837	active site 2 [active]
718255008838	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
718255008839	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
718255008840	Uncharacterized conserved protein [Function unknown]; Region: COG1434
718255008841	putative active site [active]
718255008842	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
718255008843	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718255008844	DNA-binding site [nucleotide binding]; DNA binding site
718255008845	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255008846	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718255008847	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
718255008848	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255008849	FeS/SAM binding site; other site
718255008850	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
718255008851	amidase catalytic site [active]
718255008852	Zn binding residues [ion binding]; other site
718255008853	substrate binding site [chemical binding]; other site
718255008854	Methyltransferase domain; Region: Methyltransf_31; pfam13847
718255008855	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255008856	S-adenosylmethionine binding site [chemical binding]; other site
718255008857	PAS domain S-box; Region: sensory_box; TIGR00229
718255008858	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255008859	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255008860	metal binding site [ion binding]; metal-binding site
718255008861	active site
718255008862	I-site; other site
718255008863	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718255008864	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
718255008865	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255008866	Zn2+ binding site [ion binding]; other site
718255008867	Mg2+ binding site [ion binding]; other site
718255008868	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
718255008869	DNA primase; Validated; Region: dnaG; PRK05667
718255008870	CHC2 zinc finger; Region: zf-CHC2; pfam01807
718255008871	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
718255008872	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
718255008873	active site
718255008874	metal binding site [ion binding]; metal-binding site
718255008875	interdomain interaction site; other site
718255008876	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
718255008877	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
718255008878	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
718255008879	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718255008880	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
718255008881	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255008882	DNA binding residues [nucleotide binding]
718255008883	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
718255008884	Family of unknown function (DUF633); Region: DUF633; pfam04816
718255008885	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
718255008886	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
718255008887	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
718255008888	active site
718255008889	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
718255008890	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
718255008891	HSP70 interaction site [polypeptide binding]; other site
718255008892	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
718255008893	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
718255008894	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
718255008895	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
718255008896	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
718255008897	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
718255008898	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
718255008899	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
718255008900	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
718255008901	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718255008902	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718255008903	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
718255008904	active site
718255008905	catalytic residues [active]
718255008906	metal binding site [ion binding]; metal-binding site
718255008907	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
718255008908	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
718255008909	putative active site [active]
718255008910	substrate binding site [chemical binding]; other site
718255008911	putative cosubstrate binding site; other site
718255008912	catalytic site [active]
718255008913	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
718255008914	substrate binding site [chemical binding]; other site
718255008915	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
718255008916	16S rRNA methyltransferase B; Provisional; Region: PRK14902
718255008917	NusB family; Region: NusB; pfam01029
718255008918	putative RNA binding site [nucleotide binding]; other site
718255008919	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
718255008920	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
718255008921	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255008922	FeS/SAM binding site; other site
718255008923	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
718255008924	active site
718255008925	Protein phosphatase 2C; Region: PP2C; pfam00481
718255008926	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
718255008927	Catalytic domain of Protein Kinases; Region: PKc; cd00180
718255008928	active site
718255008929	ATP binding site [chemical binding]; other site
718255008930	substrate binding site [chemical binding]; other site
718255008931	activation loop (A-loop); other site
718255008932	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
718255008933	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
718255008934	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
718255008935	GTPase RsgA; Reviewed; Region: PRK00098
718255008936	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
718255008937	RNA binding site [nucleotide binding]; other site
718255008938	homodimer interface [polypeptide binding]; other site
718255008939	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
718255008940	GTPase/Zn-binding domain interface [polypeptide binding]; other site
718255008941	GTP/Mg2+ binding site [chemical binding]; other site
718255008942	G4 box; other site
718255008943	G5 box; other site
718255008944	G1 box; other site
718255008945	Switch I region; other site
718255008946	G2 box; other site
718255008947	G3 box; other site
718255008948	Switch II region; other site
718255008949	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
718255008950	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
718255008951	substrate binding site [chemical binding]; other site
718255008952	hexamer interface [polypeptide binding]; other site
718255008953	metal binding site [ion binding]; metal-binding site
718255008954	Thiamine pyrophosphokinase; Region: TPK; cd07995
718255008955	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
718255008956	active site
718255008957	dimerization interface [polypeptide binding]; other site
718255008958	thiamine binding site [chemical binding]; other site
718255008959	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
718255008960	GTP-binding protein YchF; Reviewed; Region: PRK09601
718255008961	YchF GTPase; Region: YchF; cd01900
718255008962	G1 box; other site
718255008963	GTP/Mg2+ binding site [chemical binding]; other site
718255008964	Switch I region; other site
718255008965	G2 box; other site
718255008966	Switch II region; other site
718255008967	G3 box; other site
718255008968	G4 box; other site
718255008969	G5 box; other site
718255008970	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
718255008971	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
718255008972	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
718255008973	ATP cone domain; Region: ATP-cone; pfam03477
718255008974	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
718255008975	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
718255008976	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718255008977	active site
718255008978	motif I; other site
718255008979	motif II; other site
718255008980	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
718255008981	elongation factor P; Validated; Region: PRK00529
718255008982	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
718255008983	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
718255008984	RNA binding site [nucleotide binding]; other site
718255008985	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
718255008986	RNA binding site [nucleotide binding]; other site
718255008987	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
718255008988	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255008989	dimerization interface [polypeptide binding]; other site
718255008990	ligand binding site [chemical binding]; other site
718255008991	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255008992	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255008993	metal binding site [ion binding]; metal-binding site
718255008994	active site
718255008995	I-site; other site
718255008996	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
718255008997	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
718255008998	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718255008999	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
718255009000	active site
718255009001	Zn binding site [ion binding]; other site
718255009002	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
718255009003	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
718255009004	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
718255009005	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
718255009006	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
718255009007	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
718255009008	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
718255009009	metal ion-dependent adhesion site (MIDAS); other site
718255009010	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718255009011	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718255009012	AAA domain; Region: AAA_14; pfam13173
718255009013	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
718255009014	putative metal binding site [ion binding]; other site
718255009015	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
718255009016	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255009017	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718255009018	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718255009019	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255009020	dimer interface [polypeptide binding]; other site
718255009021	conserved gate region; other site
718255009022	putative PBP binding loops; other site
718255009023	ABC-ATPase subunit interface; other site
718255009024	NHL repeat; Region: NHL; pfam01436
718255009025	NHL repeat; Region: NHL; pfam01436
718255009026	TPR repeat; Region: TPR_11; pfam13414
718255009027	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718255009028	binding surface
718255009029	TPR motif; other site
718255009030	Yip1 domain; Region: Yip1; pfam04893
718255009031	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718255009032	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255009033	ABC-ATPase subunit interface; other site
718255009034	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255009035	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718255009036	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255009037	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255009038	DNA binding site [nucleotide binding]
718255009039	domain linker motif; other site
718255009040	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718255009041	Domain of unknown function (DUF377); Region: DUF377; pfam04041
718255009042	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
718255009043	active site
718255009044	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
718255009045	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
718255009046	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255009047	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
718255009048	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
718255009049	MoxR-like ATPases [General function prediction only]; Region: COG0714
718255009050	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718255009051	Walker A motif; other site
718255009052	ATP binding site [chemical binding]; other site
718255009053	Walker B motif; other site
718255009054	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
718255009055	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
718255009056	active site
718255009057	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
718255009058	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
718255009059	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
718255009060	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
718255009061	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
718255009062	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255009063	Walker A/P-loop; other site
718255009064	ATP binding site [chemical binding]; other site
718255009065	Q-loop/lid; other site
718255009066	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255009067	ABC transporter signature motif; other site
718255009068	Walker B; other site
718255009069	D-loop; other site
718255009070	H-loop/switch region; other site
718255009071	AAA domain; Region: AAA_23; pfam13476
718255009072	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255009073	AAA domain; Region: AAA_21; pfam13304
718255009074	Walker A/P-loop; other site
718255009075	ATP binding site [chemical binding]; other site
718255009076	Q-loop/lid; other site
718255009077	ABC transporter signature motif; other site
718255009078	Walker B; other site
718255009079	D-loop; other site
718255009080	H-loop/switch region; other site
718255009081	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
718255009082	MgtE intracellular N domain; Region: MgtE_N; pfam03448
718255009083	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
718255009084	Divalent cation transporter; Region: MgtE; pfam01769
718255009085	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
718255009086	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
718255009087	G1 box; other site
718255009088	putative GEF interaction site [polypeptide binding]; other site
718255009089	GTP/Mg2+ binding site [chemical binding]; other site
718255009090	Switch I region; other site
718255009091	G2 box; other site
718255009092	G3 box; other site
718255009093	Switch II region; other site
718255009094	G4 box; other site
718255009095	G5 box; other site
718255009096	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
718255009097	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
718255009098	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
718255009099	YacP-like NYN domain; Region: NYN_YacP; pfam05991
718255009100	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
718255009101	YheO-like PAS domain; Region: PAS_6; pfam08348
718255009102	HTH domain; Region: HTH_22; pfam13309
718255009103	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
718255009104	homotrimer interaction site [polypeptide binding]; other site
718255009105	putative active site [active]
718255009106	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
718255009107	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
718255009108	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718255009109	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255009110	homodimer interface [polypeptide binding]; other site
718255009111	catalytic residue [active]
718255009112	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
718255009113	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
718255009114	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
718255009115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255009116	S-adenosylmethionine binding site [chemical binding]; other site
718255009117	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
718255009118	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
718255009119	hypothetical protein; Provisional; Region: PRK09609
718255009120	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
718255009121	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255009122	Walker A/P-loop; other site
718255009123	ATP binding site [chemical binding]; other site
718255009124	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255009125	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718255009126	Uncharacterized conserved protein [Function unknown]; Region: COG1284
718255009127	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
718255009128	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
718255009129	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718255009130	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718255009131	metal binding site [ion binding]; metal-binding site
718255009132	active site
718255009133	I-site; other site
718255009134	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
718255009135	catalytic tetrad [active]
718255009136	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
718255009137	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255009138	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
718255009139	putative catalytic residues [active]
718255009140	catalytic nucleophile [active]
718255009141	Recombinase; Region: Recombinase; pfam07508
718255009142	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255009143	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
718255009144	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
718255009145	ATP binding site [chemical binding]; other site
718255009146	Mg2+ binding site [ion binding]; other site
718255009147	G-X-G motif; other site
718255009148	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
718255009149	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718255009150	active site
718255009151	DNA binding site [nucleotide binding]
718255009152	Int/Topo IB signature motif; other site
718255009153	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
718255009154	Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978
718255009155	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
718255009156	TM2 domain; Region: TM2; pfam05154
718255009157	Restriction endonuclease; Region: Mrr_cat; pfam04471
718255009158	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255009159	non-specific DNA binding site [nucleotide binding]; other site
718255009160	salt bridge; other site
718255009161	sequence-specific DNA binding site [nucleotide binding]; other site
718255009162	Helix-turn-helix domain; Region: HTH_17; pfam12728
718255009163	AAA domain; Region: AAA_23; pfam13476
718255009164	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255009165	Walker A/P-loop; other site
718255009166	ATP binding site [chemical binding]; other site
718255009167	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
718255009168	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
718255009169	Protein of unknown function (DUF551); Region: DUF551; pfam04448
718255009170	YopX protein; Region: YopX; pfam09643
718255009171	Domain of unknown function (DUF4417); Region: DUF4417; pfam14386
718255009172	phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
718255009173	Minor capsid protein; Region: Minor_capsid_2; pfam11114
718255009174	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
718255009175	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255009176	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255009177	non-specific DNA binding site [nucleotide binding]; other site
718255009178	salt bridge; other site
718255009179	sequence-specific DNA binding site [nucleotide binding]; other site
718255009180	AntA/AntB antirepressor; Region: AntA; cl01430
718255009181	Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053
718255009182	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
718255009183	Phage-related protein [Function unknown]; Region: COG5412
718255009184	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
718255009185	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
718255009186	basic region leucin zipper; Region: BRLZ; smart00338
718255009187	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
718255009188	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
718255009189	active site
718255009190	metal binding site [ion binding]; metal-binding site
718255009191	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
718255009192	DNA binding site [nucleotide binding]
718255009193	active site
718255009194	Int/Topo IB signature motif; other site
718255009195	catalytic residues [active]
718255009196	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
718255009197	Interdomain contacts; other site
718255009198	Cytokine receptor motif; other site
718255009199	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
718255009200	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
718255009201	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
718255009202	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
718255009203	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
718255009204	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
718255009205	core domain interface [polypeptide binding]; other site
718255009206	delta subunit interface [polypeptide binding]; other site
718255009207	epsilon subunit interface [polypeptide binding]; other site
718255009208	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
718255009209	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
718255009210	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
718255009211	alpha subunit interaction interface [polypeptide binding]; other site
718255009212	Walker A motif; other site
718255009213	ATP binding site [chemical binding]; other site
718255009214	Walker B motif; other site
718255009215	inhibitor binding site; inhibition site
718255009216	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
718255009217	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450
718255009218	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
718255009219	gamma subunit interface [polypeptide binding]; other site
718255009220	epsilon subunit interface [polypeptide binding]; other site
718255009221	LBP interface [polypeptide binding]; other site
718255009222	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255009223	Helix-turn-helix domain; Region: HTH_18; pfam12833
718255009224	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
718255009225	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255009226	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718255009227	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255009228	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
718255009229	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255009230	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718255009231	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255009232	Carbohydrate binding module 27; Region: CBM27; pfam09212
718255009233	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
718255009234	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
718255009235	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718255009236	Interdomain contacts; other site
718255009237	Cytokine receptor motif; other site
718255009238	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
718255009239	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
718255009240	Walker A/P-loop; other site
718255009241	ATP binding site [chemical binding]; other site
718255009242	Q-loop/lid; other site
718255009243	ABC transporter signature motif; other site
718255009244	Walker B; other site
718255009245	D-loop; other site
718255009246	H-loop/switch region; other site
718255009247	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
718255009248	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718255009249	substrate binding pocket [chemical binding]; other site
718255009250	membrane-bound complex binding site; other site
718255009251	hinge residues; other site
718255009252	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718255009253	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255009254	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255009255	dimer interface [polypeptide binding]; other site
718255009256	putative CheW interface [polypeptide binding]; other site
718255009257	PilZ domain; Region: PilZ; pfam07238
718255009258	Protein of unknown function (DUF419); Region: DUF419; cl15265
718255009259	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718255009260	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255009261	dimer interface [polypeptide binding]; other site
718255009262	phosphorylation site [posttranslational modification]
718255009263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255009264	ATP binding site [chemical binding]; other site
718255009265	Mg2+ binding site [ion binding]; other site
718255009266	G-X-G motif; other site
718255009267	Response regulator receiver domain; Region: Response_reg; pfam00072
718255009268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255009269	active site
718255009270	phosphorylation site [posttranslational modification]
718255009271	intermolecular recognition site; other site
718255009272	dimerization interface [polypeptide binding]; other site
718255009273	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718255009274	dimerization interface [polypeptide binding]; other site
718255009275	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718255009276	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718255009277	dimer interface [polypeptide binding]; other site
718255009278	putative CheW interface [polypeptide binding]; other site
718255009279	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
718255009280	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718255009281	nucleotide binding site [chemical binding]; other site
718255009282	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
718255009283	active site
718255009284	Uncharacterized conserved protein [Function unknown]; Region: COG3538
718255009285	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
718255009286	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
718255009287	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
718255009288	active site
718255009289	metal binding site [ion binding]; metal-binding site
718255009290	homodimer interface [polypeptide binding]; other site
718255009291	catalytic site [active]
718255009292	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
718255009293	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
718255009294	Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins.  The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547
718255009295	putative active site [active]
718255009296	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
718255009297	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
718255009298	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718255009299	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718255009300	DNA binding site [nucleotide binding]
718255009301	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718255009302	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718255009303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255009304	dimer interface [polypeptide binding]; other site
718255009305	conserved gate region; other site
718255009306	putative PBP binding loops; other site
718255009307	ABC-ATPase subunit interface; other site
718255009308	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718255009309	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255009310	dimer interface [polypeptide binding]; other site
718255009311	ABC-ATPase subunit interface; other site
718255009312	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718255009313	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
718255009314	Domain of unknown function (DUF377); Region: DUF377; pfam04041
718255009315	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
718255009316	active site
718255009317	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
718255009318	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718255009319	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
718255009320	active site
718255009321	catalytic site [active]
718255009322	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
718255009323	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
718255009324	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718255009325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718255009326	putative substrate translocation pore; other site
718255009327	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
718255009328	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718255009329	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718255009330	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
718255009331	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
718255009332	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
718255009333	putative active site [active]
718255009334	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255009335	Walker A/P-loop; other site
718255009336	ATP binding site [chemical binding]; other site
718255009337	Transglycosylase; Region: Transgly; pfam00912
718255009338	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
718255009339	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
718255009340	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
718255009341	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718255009342	nucleotide binding site [chemical binding]; other site
718255009343	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
718255009344	siroheme synthase; Provisional; Region: cysG; PRK10637
718255009345	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
718255009346	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
718255009347	active site
718255009348	SAM binding site [chemical binding]; other site
718255009349	homodimer interface [polypeptide binding]; other site
718255009350	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
718255009351	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
718255009352	Walker A/P-loop; other site
718255009353	ATP binding site [chemical binding]; other site
718255009354	Q-loop/lid; other site
718255009355	ABC transporter signature motif; other site
718255009356	Walker B; other site
718255009357	D-loop; other site
718255009358	H-loop/switch region; other site
718255009359	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
718255009360	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718255009361	ABC-ATPase subunit  interface; other site
718255009362	dimer interface [polypeptide binding]; other site
718255009363	putative PBP binding regions; other site
718255009364	Predicted transcriptional regulators [Transcription]; Region: COG1733
718255009365	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
718255009366	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
718255009367	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
718255009368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718255009369	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
718255009370	putative substrate translocation pore; other site
718255009371	Cupin domain; Region: Cupin_2; pfam07883
718255009372	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718255009373	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255009374	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255009375	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144
718255009376	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
718255009377	Transcriptional regulators [Transcription]; Region: MarR; COG1846
718255009378	MarR family; Region: MarR_2; pfam12802
718255009379	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255009380	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
718255009381	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
718255009382	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
718255009383	4Fe-4S binding domain; Region: Fer4; pfam00037
718255009384	4Fe-4S binding domain; Region: Fer4; pfam00037
718255009385	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
718255009386	CPxP  motif; other site
718255009387	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
718255009388	catalytic residues [active]
718255009389	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
718255009390	thiS-thiF/thiG interaction site; other site
718255009391	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
718255009392	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
718255009393	ATP binding site [chemical binding]; other site
718255009394	substrate interface [chemical binding]; other site
718255009395	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
718255009396	MPN+ (JAMM) motif; other site
718255009397	Zinc-binding site [ion binding]; other site
718255009398	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
718255009399	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718255009400	Coenzyme A binding pocket [chemical binding]; other site
718255009401	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255009402	Radical SAM superfamily; Region: Radical_SAM; pfam04055
718255009403	FeS/SAM binding site; other site
718255009404	acyl carrier protein; Provisional; Region: acpP; PRK00982
718255009405	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
718255009406	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
718255009407	FMN binding site [chemical binding]; other site
718255009408	substrate binding site [chemical binding]; other site
718255009409	putative catalytic residue [active]
718255009410	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
718255009411	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
718255009412	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
718255009413	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
718255009414	NAD(P) binding site [chemical binding]; other site
718255009415	homotetramer interface [polypeptide binding]; other site
718255009416	homodimer interface [polypeptide binding]; other site
718255009417	active site
718255009418	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
718255009419	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
718255009420	dimer interface [polypeptide binding]; other site
718255009421	active site
718255009422	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
718255009423	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
718255009424	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
718255009425	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
718255009426	dimer interface [polypeptide binding]; other site
718255009427	active site
718255009428	CoA binding pocket [chemical binding]; other site
718255009429	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
718255009430	MarR family; Region: MarR; pfam01047
718255009431	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
718255009432	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
718255009433	NAD binding site [chemical binding]; other site
718255009434	dimer interface [polypeptide binding]; other site
718255009435	substrate binding site [chemical binding]; other site
718255009436	tetramer (dimer of dimers) interface [polypeptide binding]; other site
718255009437	Domain of unknown function (DUF4321); Region: DUF4321; pfam14209
718255009438	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
718255009439	glutamate dehydrogenase; Provisional; Region: PRK09414
718255009440	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
718255009441	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
718255009442	NAD(P) binding site [chemical binding]; other site
718255009443	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
718255009444	DNA binding site [nucleotide binding]
718255009445	active site
718255009446	Int/Topo IB signature motif; other site
718255009447	catalytic residues [active]
718255009448	Helix-turn-helix domain; Region: HTH_17; pfam12728
718255009449	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889
718255009450	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
718255009451	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
718255009452	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718255009453	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255009454	DNA binding residues [nucleotide binding]
718255009455	chromosome segregation protein; Provisional; Region: PRK03918
718255009456	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
718255009457	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718255009458	cofactor binding site; other site
718255009459	DNA binding site [nucleotide binding]
718255009460	substrate interaction site [chemical binding]; other site
718255009461	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718255009462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
718255009463	active site
718255009464	phosphorylation site [posttranslational modification]
718255009465	intermolecular recognition site; other site
718255009466	FOG: CBS domain [General function prediction only]; Region: COG0517
718255009467	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
718255009468	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718255009469	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
718255009470	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
718255009471	putative transporter; Provisional; Region: PRK11660
718255009472	Sulfate transporter family; Region: Sulfate_transp; pfam00916
718255009473	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
718255009474	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
718255009475	DNA binding site [nucleotide binding]
718255009476	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
718255009477	active site
718255009478	Transcriptional regulator; Region: Rrf2; cl17282
718255009479	Rrf2 family protein; Region: rrf2_super; TIGR00738
718255009480	Domain of unknown function, E. rectale Gene description (DUF3877); Region: DUF3877; pfam12993
718255009481	2-isopropylmalate synthase; Validated; Region: PRK03739
718255009482	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
718255009483	active site
718255009484	catalytic residues [active]
718255009485	metal binding site [ion binding]; metal-binding site
718255009486	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
718255009487	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718255009488	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
718255009489	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718255009490	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
718255009491	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
718255009492	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
718255009493	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
718255009494	Domain of unknown function DUF21; Region: DUF21; pfam01595
718255009495	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
718255009496	Transporter associated domain; Region: CorC_HlyC; pfam03471
718255009497	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
718255009498	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
718255009499	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718255009500	catalytic residue [active]
718255009501	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
718255009502	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
718255009503	trimerization site [polypeptide binding]; other site
718255009504	active site
718255009505	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
718255009506	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
718255009507	homodimer interface [polypeptide binding]; other site
718255009508	substrate-cofactor binding pocket; other site
718255009509	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255009510	catalytic residue [active]
718255009511	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
718255009512	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
718255009513	dimer interface [polypeptide binding]; other site
718255009514	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718255009515	catalytic residue [active]
718255009516	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
718255009517	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
718255009518	Catalytic site [active]
718255009519	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
718255009520	Cation efflux family; Region: Cation_efflux; pfam01545
718255009521	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
718255009522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255009523	active site
718255009524	phosphorylation site [posttranslational modification]
718255009525	intermolecular recognition site; other site
718255009526	dimerization interface [polypeptide binding]; other site
718255009527	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718255009528	Zn2+ binding site [ion binding]; other site
718255009529	Mg2+ binding site [ion binding]; other site
718255009530	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
718255009531	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255009532	dimer interface [polypeptide binding]; other site
718255009533	phosphorylation site [posttranslational modification]
718255009534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255009535	ATP binding site [chemical binding]; other site
718255009536	Mg2+ binding site [ion binding]; other site
718255009537	G-X-G motif; other site
718255009538	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
718255009539	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255009540	active site
718255009541	phosphorylation site [posttranslational modification]
718255009542	intermolecular recognition site; other site
718255009543	dimerization interface [polypeptide binding]; other site
718255009544	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
718255009545	putative binding surface; other site
718255009546	active site
718255009547	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
718255009548	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718255009549	dimer interface [polypeptide binding]; other site
718255009550	phosphorylation site [posttranslational modification]
718255009551	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718255009552	ATP binding site [chemical binding]; other site
718255009553	Mg2+ binding site [ion binding]; other site
718255009554	G-X-G motif; other site
718255009555	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
718255009556	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718255009557	active site
718255009558	phosphorylation site [posttranslational modification]
718255009559	intermolecular recognition site; other site
718255009560	dimerization interface [polypeptide binding]; other site
718255009561	EDD domain protein, DegV family; Region: DegV; TIGR00762
718255009562	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
718255009563	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
718255009564	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
718255009565	catalytic motif [active]
718255009566	Zn binding site [ion binding]; other site
718255009567	RibD C-terminal domain; Region: RibD_C; cl17279
718255009568	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
718255009569	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
718255009570	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
718255009571	dimerization interface [polypeptide binding]; other site
718255009572	active site
718255009573	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
718255009574	homopentamer interface [polypeptide binding]; other site
718255009575	active site
718255009576	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
718255009577	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
718255009578	Sulfatase; Region: Sulfatase; pfam00884
718255009579	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
718255009580	trimer interface [polypeptide binding]; other site
718255009581	dimer interface [polypeptide binding]; other site
718255009582	putative active site [active]
718255009583	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
718255009584	MPT binding site; other site
718255009585	trimer interface [polypeptide binding]; other site
718255009586	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
718255009587	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
718255009588	CPxP  motif; other site
718255009589	DsrE/DsrF-like family; Region: DrsE; pfam02635
718255009590	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
718255009591	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
718255009592	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718255009593	catalytic residue [active]
718255009594	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
718255009595	selenophosphate synthetase; Provisional; Region: PRK00943
718255009596	dimerization interface [polypeptide binding]; other site
718255009597	putative ATP binding site [chemical binding]; other site
718255009598	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
718255009599	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
718255009600	putative MPT binding site; other site
718255009601	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
718255009602	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718255009603	FeS/SAM binding site; other site
718255009604	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
718255009605	MOSC domain; Region: MOSC; pfam03473
718255009606	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
718255009607	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
718255009608	XdhC Rossmann domain; Region: XdhC_C; pfam13478
718255009609	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
718255009610	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
718255009611	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
718255009612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718255009613	dimer interface [polypeptide binding]; other site
718255009614	conserved gate region; other site
718255009615	putative PBP binding loops; other site
718255009616	ABC-ATPase subunit interface; other site
718255009617	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255009618	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
718255009619	Walker A/P-loop; other site
718255009620	ATP binding site [chemical binding]; other site
718255009621	Q-loop/lid; other site
718255009622	ABC transporter signature motif; other site
718255009623	Walker B; other site
718255009624	D-loop; other site
718255009625	H-loop/switch region; other site
718255009626	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718255009627	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718255009628	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
718255009629	putative dimerization interface [polypeptide binding]; other site
718255009630	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
718255009631	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
718255009632	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
718255009633	putative L-serine binding site [chemical binding]; other site
718255009634	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
718255009635	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
718255009636	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718255009637	DNA-binding site [nucleotide binding]; DNA binding site
718255009638	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
718255009639	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
718255009640	Walker A/P-loop; other site
718255009641	ATP binding site [chemical binding]; other site
718255009642	Q-loop/lid; other site
718255009643	ABC transporter signature motif; other site
718255009644	Walker B; other site
718255009645	D-loop; other site
718255009646	H-loop/switch region; other site
718255009647	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
718255009648	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
718255009649	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
718255009650	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
718255009651	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
718255009652	putative metal binding site; other site
718255009653	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
718255009654	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
718255009655	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
718255009656	putative RNA binding site [nucleotide binding]; other site
718255009657	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255009658	S-adenosylmethionine binding site [chemical binding]; other site
718255009659	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
718255009660	putative FMN binding site [chemical binding]; other site
718255009661	Predicted transcriptional regulators [Transcription]; Region: COG1733
718255009662	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
718255009663	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
718255009664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255009665	S-adenosylmethionine binding site [chemical binding]; other site
718255009666	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
718255009667	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718255009668	P-loop; other site
718255009669	Magnesium ion binding site [ion binding]; other site
718255009670	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718255009671	Magnesium ion binding site [ion binding]; other site
718255009672	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
718255009673	Cna protein B-type domain; Region: Cna_B; pfam05738
718255009674	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
718255009675	Cna protein B-type domain; Region: Cna_B; pfam05738
718255009676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718255009677	S-adenosylmethionine binding site [chemical binding]; other site
718255009678	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
718255009679	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
718255009680	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
718255009681	nucleotide binding region [chemical binding]; other site
718255009682	helicase superfamily c-terminal domain; Region: HELICc; smart00490
718255009683	ATP-binding site [chemical binding]; other site
718255009684	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
718255009685	Toprim-like; Region: Toprim_2; pfam13155
718255009686	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
718255009687	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
718255009688	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
718255009689	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
718255009690	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718255009691	Walker A motif; other site
718255009692	ATP binding site [chemical binding]; other site
718255009693	Walker B motif; other site
718255009694	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
718255009695	Domain of unknown function DUF87; Region: DUF87; pfam01935
718255009696	AAA-like domain; Region: AAA_10; pfam12846
718255009697	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
718255009698	active site
718255009699	catalytic site [active]
718255009700	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
718255009701	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
718255009702	N-acetyl-D-glucosamine binding site [chemical binding]; other site
718255009703	catalytic residue [active]
718255009704	CHAP domain; Region: CHAP; cl17642
718255009705	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718255009706	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718255009707	non-specific DNA binding site [nucleotide binding]; other site
718255009708	salt bridge; other site
718255009709	sequence-specific DNA binding site [nucleotide binding]; other site
718255009710	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
718255009711	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718255009712	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255009713	DNA binding residues [nucleotide binding]
718255009714	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
718255009715	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255009716	Walker A/P-loop; other site
718255009717	ATP binding site [chemical binding]; other site
718255009718	Q-loop/lid; other site
718255009719	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718255009720	ABC transporter signature motif; other site
718255009721	Walker B; other site
718255009722	D-loop; other site
718255009723	H-loop/switch region; other site
718255009724	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
718255009725	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
718255009726	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718255009727	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718255009728	DNA binding residues [nucleotide binding]
718255009729	PemK-like protein; Region: PemK; pfam02452
718255009730	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718255009731	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
718255009732	catalytic residues [active]
718255009733	catalytic nucleophile [active]
718255009734	Recombinase; Region: Recombinase; pfam07508
718255009735	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718255009736	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
718255009737	SpoVG; Region: SpoVG; cl00915
718255009738	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
718255009739	YodL-like; Region: YodL; pfam14191
718255009740	SpoVG; Region: SpoVG; cl00915