-- dump date   	20140620_040640
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
657315000001	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657315000002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315000003	active site
657315000004	phosphorylation site [posttranslational modification]
657315000005	intermolecular recognition site; other site
657315000006	dimerization interface [polypeptide binding]; other site
657315000007	LytTr DNA-binding domain; Region: LytTR; pfam04397
657315000008	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
657315000009	Accessory gene regulator B; Region: AgrB; pfam04647
657315000010	Staphylococcal AgrD protein; Region: AgrD; cl05477
657315000011	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
657315000012	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
657315000013	putative active site [active]
657315000014	putative NTP binding site [chemical binding]; other site
657315000015	putative nucleic acid binding site [nucleotide binding]; other site
657315000016	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
657315000017	PemK-like protein; Region: PemK; pfam02452
657315000018	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315000019	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657315000020	catalytic residues [active]
657315000021	catalytic nucleophile [active]
657315000022	Recombinase; Region: Recombinase; pfam07508
657315000023	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315000024	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315000025	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657315000026	catalytic residues [active]
657315000027	catalytic nucleophile [active]
657315000028	Recombinase; Region: Recombinase; pfam07508
657315000029	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315000030	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657315000031	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315000032	catalytic residues [active]
657315000033	catalytic nucleophile [active]
657315000034	Recombinase; Region: Recombinase; pfam07508
657315000035	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315000036	hypothetical protein; Provisional; Region: PRK13685
657315000037	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
657315000038	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
657315000039	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
657315000040	putative dimer interface [polypeptide binding]; other site
657315000041	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315000042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315000043	active site
657315000044	phosphorylation site [posttranslational modification]
657315000045	intermolecular recognition site; other site
657315000046	dimerization interface [polypeptide binding]; other site
657315000047	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315000048	DNA binding site [nucleotide binding]
657315000049	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
657315000050	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315000051	dimerization interface [polypeptide binding]; other site
657315000052	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315000053	dimer interface [polypeptide binding]; other site
657315000054	phosphorylation site [posttranslational modification]
657315000055	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315000056	ATP binding site [chemical binding]; other site
657315000057	Mg2+ binding site [ion binding]; other site
657315000058	G-X-G motif; other site
657315000059	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
657315000060	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
657315000061	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
657315000062	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
657315000063	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657315000064	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315000065	active site
657315000066	phosphorylation site [posttranslational modification]
657315000067	intermolecular recognition site; other site
657315000068	dimerization interface [polypeptide binding]; other site
657315000069	LytTr DNA-binding domain; Region: LytTR; smart00850
657315000070	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
657315000071	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
657315000072	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
657315000073	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
657315000074	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
657315000075	GtrA-like protein; Region: GtrA; pfam04138
657315000076	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
657315000077	Flavin Reductases; Region: FlaRed; cl00801
657315000078	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
657315000079	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
657315000080	homodimer interface [polypeptide binding]; other site
657315000081	substrate-cofactor binding pocket; other site
657315000082	catalytic residue [active]
657315000083	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
657315000084	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
657315000085	active site
657315000086	Zn binding site [ion binding]; other site
657315000087	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
657315000088	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
657315000089	DHH family; Region: DHH; pfam01368
657315000090	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
657315000091	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657315000092	active site
657315000093	HIGH motif; other site
657315000094	nucleotide binding site [chemical binding]; other site
657315000095	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
657315000096	active site
657315000097	KMSKS motif; other site
657315000098	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
657315000099	tRNA binding surface [nucleotide binding]; other site
657315000100	anticodon binding site; other site
657315000101	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
657315000102	homodimer interface [polypeptide binding]; other site
657315000103	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
657315000104	active site pocket [active]
657315000105	Predicted membrane protein [Function unknown]; Region: COG4818
657315000106	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315000107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315000108	active site
657315000109	phosphorylation site [posttranslational modification]
657315000110	intermolecular recognition site; other site
657315000111	dimerization interface [polypeptide binding]; other site
657315000112	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315000113	DNA binding site [nucleotide binding]
657315000114	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
657315000115	RNA binding site [nucleotide binding]; other site
657315000116	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
657315000117	RNA binding site [nucleotide binding]; other site
657315000118	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
657315000119	RNA binding site [nucleotide binding]; other site
657315000120	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
657315000121	MarR family; Region: MarR; pfam01047
657315000122	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
657315000123	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
657315000124	N-acetyl-D-glucosamine binding site [chemical binding]; other site
657315000125	catalytic residue [active]
657315000126	AzlC protein; Region: AzlC; cl00570
657315000127	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
657315000128	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
657315000129	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
657315000130	active site
657315000131	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
657315000132	substrate binding site [chemical binding]; other site
657315000133	catalytic residues [active]
657315000134	dimer interface [polypeptide binding]; other site
657315000135	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
657315000136	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
657315000137	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
657315000138	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
657315000139	putative dimer interface [polypeptide binding]; other site
657315000140	putative anticodon binding site; other site
657315000141	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
657315000142	homodimer interface [polypeptide binding]; other site
657315000143	motif 1; other site
657315000144	motif 2; other site
657315000145	active site
657315000146	motif 3; other site
657315000147	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
657315000148	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
657315000149	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
657315000150	active site
657315000151	catalytic residues [active]
657315000152	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
657315000153	xanthine permease; Region: pbuX; TIGR03173
657315000154	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
657315000155	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
657315000156	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
657315000157	Protein export membrane protein; Region: SecD_SecF; pfam02355
657315000158	Predicted membrane protein [Function unknown]; Region: COG3326
657315000159	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
657315000160	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
657315000161	dimer interface [polypeptide binding]; other site
657315000162	active site
657315000163	glycine-pyridoxal phosphate binding site [chemical binding]; other site
657315000164	folate binding site [chemical binding]; other site
657315000165	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
657315000166	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
657315000167	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
657315000168	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
657315000169	ADP/pyrophosphate binding site [chemical binding]; other site
657315000170	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
657315000171	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
657315000172	Clp amino terminal domain; Region: Clp_N; pfam02861
657315000173	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315000174	Walker A motif; other site
657315000175	ATP binding site [chemical binding]; other site
657315000176	Walker B motif; other site
657315000177	arginine finger; other site
657315000178	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315000179	Walker A motif; other site
657315000180	ATP binding site [chemical binding]; other site
657315000181	Walker B motif; other site
657315000182	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
657315000183	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657315000184	Interdomain contacts; other site
657315000185	Cytokine receptor motif; other site
657315000186	DNA repair protein RadA; Provisional; Region: PRK11823
657315000187	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
657315000188	Walker A motif/ATP binding site; other site
657315000189	ATP binding site [chemical binding]; other site
657315000190	Walker B motif; other site
657315000191	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
657315000192	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
657315000193	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315000194	active site
657315000195	DNA binding site [nucleotide binding]
657315000196	Int/Topo IB signature motif; other site
657315000197	Putative transposase; Region: Y2_Tnp; pfam04986
657315000198	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657315000199	DNA binding residues [nucleotide binding]
657315000200	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
657315000201	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
657315000202	F0F1 ATP synthase subunit B; Provisional; Region: PRK13461
657315000203	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
657315000204	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
657315000205	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
657315000206	core domain interface [polypeptide binding]; other site
657315000207	delta subunit interface [polypeptide binding]; other site
657315000208	epsilon subunit interface [polypeptide binding]; other site
657315000209	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
657315000210	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
657315000211	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
657315000212	alpha subunit interaction interface [polypeptide binding]; other site
657315000213	Walker A motif; other site
657315000214	ATP binding site [chemical binding]; other site
657315000215	Walker B motif; other site
657315000216	inhibitor binding site; inhibition site
657315000217	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
657315000218	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450
657315000219	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
657315000220	gamma subunit interface [polypeptide binding]; other site
657315000221	epsilon subunit interface [polypeptide binding]; other site
657315000222	LBP interface [polypeptide binding]; other site
657315000223	Cupin domain; Region: Cupin_2; pfam07883
657315000224	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315000225	Helix-turn-helix domain; Region: HTH_18; pfam12833
657315000226	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
657315000227	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
657315000228	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
657315000229	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
657315000230	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
657315000231	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
657315000232	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
657315000233	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
657315000234	Carbohydrate binding module 27; Region: CBM27; pfam09212
657315000235	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
657315000236	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
657315000237	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657315000238	Interdomain contacts; other site
657315000239	Cytokine receptor motif; other site
657315000240	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
657315000241	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
657315000242	Walker A/P-loop; other site
657315000243	ATP binding site [chemical binding]; other site
657315000244	Q-loop/lid; other site
657315000245	ABC transporter signature motif; other site
657315000246	Walker B; other site
657315000247	D-loop; other site
657315000248	H-loop/switch region; other site
657315000249	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
657315000250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315000251	dimer interface [polypeptide binding]; other site
657315000252	conserved gate region; other site
657315000253	putative PBP binding loops; other site
657315000254	ABC-ATPase subunit interface; other site
657315000255	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
657315000256	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
657315000257	substrate binding pocket [chemical binding]; other site
657315000258	membrane-bound complex binding site; other site
657315000259	hinge residues; other site
657315000260	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
657315000261	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315000262	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315000263	dimer interface [polypeptide binding]; other site
657315000264	putative CheW interface [polypeptide binding]; other site
657315000265	PilZ domain; Region: PilZ; pfam07238
657315000266	Protein of unknown function (DUF419); Region: DUF419; cl15265
657315000267	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
657315000268	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
657315000269	nucleotide binding site [chemical binding]; other site
657315000270	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
657315000271	active site
657315000272	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657315000273	DNA-binding site [nucleotide binding]; DNA binding site
657315000274	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315000275	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657315000276	ligand binding site [chemical binding]; other site
657315000277	dimerization interface [polypeptide binding]; other site
657315000278	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
657315000279	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
657315000280	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315000281	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315000282	metal binding site [ion binding]; metal-binding site
657315000283	active site
657315000284	I-site; other site
657315000285	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
657315000286	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
657315000287	active site
657315000288	metal binding site [ion binding]; metal-binding site
657315000289	DNA binding site [nucleotide binding]
657315000290	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315000291	Walker A/P-loop; other site
657315000292	ATP binding site [chemical binding]; other site
657315000293	Transglycosylase; Region: Transgly; pfam00912
657315000294	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
657315000295	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
657315000296	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
657315000297	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
657315000298	nucleotide binding site [chemical binding]; other site
657315000299	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
657315000300	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
657315000301	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
657315000302	intersubunit interface [polypeptide binding]; other site
657315000303	siroheme synthase; Provisional; Region: cysG; PRK10637
657315000304	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
657315000305	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
657315000306	active site
657315000307	SAM binding site [chemical binding]; other site
657315000308	homodimer interface [polypeptide binding]; other site
657315000309	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
657315000310	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
657315000311	Walker A/P-loop; other site
657315000312	ATP binding site [chemical binding]; other site
657315000313	Q-loop/lid; other site
657315000314	ABC transporter signature motif; other site
657315000315	Walker B; other site
657315000316	D-loop; other site
657315000317	H-loop/switch region; other site
657315000318	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
657315000319	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
657315000320	ABC-ATPase subunit  interface; other site
657315000321	dimer interface [polypeptide binding]; other site
657315000322	putative PBP binding regions; other site
657315000323	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
657315000324	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
657315000325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657315000326	putative substrate translocation pore; other site
657315000327	Cupin domain; Region: Cupin_2; pfam07883
657315000328	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315000329	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315000330	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315000331	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144
657315000332	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
657315000333	Transcriptional regulators [Transcription]; Region: MarR; COG1846
657315000334	MarR family; Region: MarR_2; pfam12802
657315000335	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657315000336	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315000337	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
657315000338	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
657315000339	4Fe-4S binding domain; Region: Fer4; pfam00037
657315000340	4Fe-4S binding domain; Region: Fer4; pfam00037
657315000341	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
657315000342	CPxP  motif; other site
657315000343	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
657315000344	catalytic residues [active]
657315000345	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
657315000346	thiS-thiF/thiG interaction site; other site
657315000347	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
657315000348	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
657315000349	ATP binding site [chemical binding]; other site
657315000350	substrate interface [chemical binding]; other site
657315000351	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
657315000352	MPN+ (JAMM) motif; other site
657315000353	Zinc-binding site [ion binding]; other site
657315000354	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
657315000355	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657315000356	Coenzyme A binding pocket [chemical binding]; other site
657315000357	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315000358	Radical SAM superfamily; Region: Radical_SAM; pfam04055
657315000359	FeS/SAM binding site; other site
657315000360	acyl carrier protein; Provisional; Region: acpP; PRK00982
657315000361	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
657315000362	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
657315000363	FMN binding site [chemical binding]; other site
657315000364	substrate binding site [chemical binding]; other site
657315000365	putative catalytic residue [active]
657315000366	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
657315000367	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
657315000368	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
657315000369	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
657315000370	NAD(P) binding site [chemical binding]; other site
657315000371	homotetramer interface [polypeptide binding]; other site
657315000372	homodimer interface [polypeptide binding]; other site
657315000373	active site
657315000374	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
657315000375	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
657315000376	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
657315000377	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
657315000378	MarR family; Region: MarR; pfam01047
657315000379	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
657315000380	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
657315000381	NAD binding site [chemical binding]; other site
657315000382	dimer interface [polypeptide binding]; other site
657315000383	substrate binding site [chemical binding]; other site
657315000384	tetramer (dimer of dimers) interface [polypeptide binding]; other site
657315000385	SdpI/YhfL protein family; Region: SdpI; pfam13630
657315000386	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
657315000387	Domain of unknown function (DUF4321); Region: DUF4321; pfam14209
657315000388	glutamate dehydrogenase; Provisional; Region: PRK09414
657315000389	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
657315000390	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
657315000391	NAD(P) binding site [chemical binding]; other site
657315000392	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
657315000393	DNA binding site [nucleotide binding]
657315000394	active site
657315000395	Int/Topo IB signature motif; other site
657315000396	catalytic residues [active]
657315000397	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315000398	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315000399	sequence-specific DNA binding site [nucleotide binding]; other site
657315000400	salt bridge; other site
657315000401	Helix-turn-helix domain; Region: HTH_17; pfam12728
657315000402	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889
657315000403	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
657315000404	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
657315000405	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657315000406	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657315000407	DNA binding residues [nucleotide binding]
657315000408	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
657315000409	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
657315000410	Walker A/P-loop; other site
657315000411	ATP binding site [chemical binding]; other site
657315000412	Q-loop/lid; other site
657315000413	ABC transporter signature motif; other site
657315000414	Walker B; other site
657315000415	D-loop; other site
657315000416	H-loop/switch region; other site
657315000417	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
657315000418	chromosome segregation protein; Provisional; Region: PRK03918
657315000419	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
657315000420	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
657315000421	cofactor binding site; other site
657315000422	DNA binding site [nucleotide binding]
657315000423	substrate interaction site [chemical binding]; other site
657315000424	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
657315000425	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
657315000426	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315000427	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315000428	ATP binding site [chemical binding]; other site
657315000429	Mg2+ binding site [ion binding]; other site
657315000430	G-X-G motif; other site
657315000431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
657315000432	active site
657315000433	phosphorylation site [posttranslational modification]
657315000434	intermolecular recognition site; other site
657315000435	FOG: CBS domain [General function prediction only]; Region: COG0517
657315000436	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
657315000437	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315000438	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
657315000439	Sporulation and spore germination; Region: Germane; pfam10646
657315000440	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
657315000441	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
657315000442	putative transporter; Provisional; Region: PRK11660
657315000443	Sulfate transporter family; Region: Sulfate_transp; pfam00916
657315000444	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
657315000445	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
657315000446	DNA binding site [nucleotide binding]
657315000447	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
657315000448	active site
657315000449	Transcriptional regulator; Region: Rrf2; cl17282
657315000450	Rrf2 family protein; Region: rrf2_super; TIGR00738
657315000451	Domain of unknown function, E. rectale Gene description (DUF3877); Region: DUF3877; pfam12993
657315000452	2-isopropylmalate synthase; Validated; Region: PRK03739
657315000453	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
657315000454	active site
657315000455	catalytic residues [active]
657315000456	metal binding site [ion binding]; metal-binding site
657315000457	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
657315000458	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657315000459	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
657315000460	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315000461	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
657315000462	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
657315000463	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
657315000464	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
657315000465	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
657315000466	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657315000467	catalytic residue [active]
657315000468	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
657315000469	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
657315000470	trimerization site [polypeptide binding]; other site
657315000471	active site
657315000472	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
657315000473	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
657315000474	homodimer interface [polypeptide binding]; other site
657315000475	substrate-cofactor binding pocket; other site
657315000476	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315000477	catalytic residue [active]
657315000478	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
657315000479	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
657315000480	dimer interface [polypeptide binding]; other site
657315000481	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315000482	catalytic residue [active]
657315000483	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
657315000484	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
657315000485	Catalytic site [active]
657315000486	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
657315000487	Cation efflux family; Region: Cation_efflux; pfam01545
657315000488	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
657315000489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315000490	active site
657315000491	phosphorylation site [posttranslational modification]
657315000492	intermolecular recognition site; other site
657315000493	dimerization interface [polypeptide binding]; other site
657315000494	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315000495	Zn2+ binding site [ion binding]; other site
657315000496	Mg2+ binding site [ion binding]; other site
657315000497	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
657315000498	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315000499	dimer interface [polypeptide binding]; other site
657315000500	phosphorylation site [posttranslational modification]
657315000501	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315000502	ATP binding site [chemical binding]; other site
657315000503	Mg2+ binding site [ion binding]; other site
657315000504	G-X-G motif; other site
657315000505	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
657315000506	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315000507	active site
657315000508	phosphorylation site [posttranslational modification]
657315000509	intermolecular recognition site; other site
657315000510	dimerization interface [polypeptide binding]; other site
657315000511	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
657315000512	putative binding surface; other site
657315000513	active site
657315000514	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
657315000515	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315000516	dimer interface [polypeptide binding]; other site
657315000517	phosphorylation site [posttranslational modification]
657315000518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315000519	ATP binding site [chemical binding]; other site
657315000520	Mg2+ binding site [ion binding]; other site
657315000521	G-X-G motif; other site
657315000522	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
657315000523	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315000524	active site
657315000525	phosphorylation site [posttranslational modification]
657315000526	intermolecular recognition site; other site
657315000527	dimerization interface [polypeptide binding]; other site
657315000528	EDD domain protein, DegV family; Region: DegV; TIGR00762
657315000529	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
657315000530	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
657315000531	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
657315000532	catalytic motif [active]
657315000533	Zn binding site [ion binding]; other site
657315000534	RibD C-terminal domain; Region: RibD_C; cl17279
657315000535	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
657315000536	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
657315000537	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
657315000538	dimerization interface [polypeptide binding]; other site
657315000539	active site
657315000540	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
657315000541	homopentamer interface [polypeptide binding]; other site
657315000542	active site
657315000543	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
657315000544	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
657315000545	Sulfatase; Region: Sulfatase; pfam00884
657315000546	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
657315000547	trimer interface [polypeptide binding]; other site
657315000548	dimer interface [polypeptide binding]; other site
657315000549	putative active site [active]
657315000550	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
657315000551	MPT binding site; other site
657315000552	trimer interface [polypeptide binding]; other site
657315000553	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
657315000554	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
657315000555	CPxP  motif; other site
657315000556	DsrE/DsrF-like family; Region: DrsE; pfam02635
657315000557	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
657315000558	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
657315000559	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657315000560	catalytic residue [active]
657315000561	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
657315000562	selenophosphate synthetase; Provisional; Region: PRK00943
657315000563	dimerization interface [polypeptide binding]; other site
657315000564	putative ATP binding site [chemical binding]; other site
657315000565	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
657315000566	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
657315000567	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
657315000568	putative MPT binding site; other site
657315000569	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
657315000570	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315000571	FeS/SAM binding site; other site
657315000572	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
657315000573	MOSC domain; Region: MOSC; pfam03473
657315000574	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
657315000575	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
657315000576	XdhC Rossmann domain; Region: XdhC_C; pfam13478
657315000577	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
657315000578	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
657315000579	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
657315000580	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315000581	dimer interface [polypeptide binding]; other site
657315000582	conserved gate region; other site
657315000583	putative PBP binding loops; other site
657315000584	ABC-ATPase subunit interface; other site
657315000585	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315000586	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
657315000587	Walker A/P-loop; other site
657315000588	ATP binding site [chemical binding]; other site
657315000589	Q-loop/lid; other site
657315000590	ABC transporter signature motif; other site
657315000591	Walker B; other site
657315000592	D-loop; other site
657315000593	H-loop/switch region; other site
657315000594	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657315000595	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657315000596	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
657315000597	putative dimerization interface [polypeptide binding]; other site
657315000598	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
657315000599	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
657315000600	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
657315000601	putative L-serine binding site [chemical binding]; other site
657315000602	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
657315000603	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
657315000604	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657315000605	DNA-binding site [nucleotide binding]; DNA binding site
657315000606	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
657315000607	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
657315000608	Walker A/P-loop; other site
657315000609	ATP binding site [chemical binding]; other site
657315000610	Q-loop/lid; other site
657315000611	ABC transporter signature motif; other site
657315000612	Walker B; other site
657315000613	D-loop; other site
657315000614	H-loop/switch region; other site
657315000615	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
657315000616	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
657315000617	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
657315000618	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657315000619	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
657315000620	putative metal binding site; other site
657315000621	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
657315000622	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
657315000623	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
657315000624	putative RNA binding site [nucleotide binding]; other site
657315000625	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315000626	S-adenosylmethionine binding site [chemical binding]; other site
657315000627	Predicted transcriptional regulators [Transcription]; Region: COG1725
657315000628	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657315000629	DNA-binding site [nucleotide binding]; DNA binding site
657315000630	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
657315000631	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315000632	Walker A/P-loop; other site
657315000633	ATP binding site [chemical binding]; other site
657315000634	Q-loop/lid; other site
657315000635	ABC transporter signature motif; other site
657315000636	Walker B; other site
657315000637	D-loop; other site
657315000638	H-loop/switch region; other site
657315000639	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
657315000640	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
657315000641	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315000642	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315000643	non-specific DNA binding site [nucleotide binding]; other site
657315000644	salt bridge; other site
657315000645	sequence-specific DNA binding site [nucleotide binding]; other site
657315000646	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657315000647	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315000648	active site
657315000649	phosphorylation site [posttranslational modification]
657315000650	intermolecular recognition site; other site
657315000651	dimerization interface [polypeptide binding]; other site
657315000652	LytTr DNA-binding domain; Region: LytTR; pfam04397
657315000653	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
657315000654	Accessory gene regulator B; Region: AgrB; pfam04647
657315000655	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
657315000656	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657315000657	DNA binding residues [nucleotide binding]
657315000658	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315000659	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
657315000660	catalytic residues [active]
657315000661	catalytic nucleophile [active]
657315000662	Recombinase; Region: Recombinase; pfam07508
657315000663	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315000664	Recombinase; Region: Recombinase; pfam07508
657315000665	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315000666	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315000667	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
657315000668	catalytic residues [active]
657315000669	catalytic nucleophile [active]
657315000670	Recombinase; Region: Recombinase; pfam07508
657315000671	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315000672	AAA ATPase domain; Region: AAA_16; pfam13191
657315000673	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
657315000674	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
657315000675	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
657315000676	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
657315000677	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
657315000678	HsdM N-terminal domain; Region: HsdM_N; pfam12161
657315000679	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315000680	S-adenosylmethionine binding site [chemical binding]; other site
657315000681	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
657315000682	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
657315000683	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
657315000684	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
657315000685	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
657315000686	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
657315000687	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
657315000688	ATP binding site [chemical binding]; other site
657315000689	putative Mg++ binding site [ion binding]; other site
657315000690	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
657315000691	sequence-specific DNA binding site [nucleotide binding]; other site
657315000692	salt bridge; other site
657315000693	Uncharacterized conserved protein [Function unknown]; Region: COG1479
657315000694	Protein of unknown function DUF262; Region: DUF262; pfam03235
657315000695	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315000696	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
657315000697	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
657315000698	Int/Topo IB signature motif; other site
657315000699	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315000700	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315000701	non-specific DNA binding site [nucleotide binding]; other site
657315000702	salt bridge; other site
657315000703	sequence-specific DNA binding site [nucleotide binding]; other site
657315000704	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
657315000705	Accessory gene regulator B; Region: AgrB; pfam04647
657315000706	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657315000707	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315000708	active site
657315000709	phosphorylation site [posttranslational modification]
657315000710	intermolecular recognition site; other site
657315000711	dimerization interface [polypeptide binding]; other site
657315000712	LytTr DNA-binding domain; Region: LytTR; pfam04397
657315000713	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
657315000714	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
657315000715	active site
657315000716	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657315000717	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
657315000718	Walker A/P-loop; other site
657315000719	ATP binding site [chemical binding]; other site
657315000720	Q-loop/lid; other site
657315000721	ABC transporter signature motif; other site
657315000722	Walker B; other site
657315000723	D-loop; other site
657315000724	H-loop/switch region; other site
657315000725	Protein of unknown function (DUF419); Region: DUF419; pfam04237
657315000726	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657315000727	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657315000728	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315000729	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
657315000730	putative efflux protein, MATE family; Region: matE; TIGR00797
657315000731	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
657315000732	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
657315000733	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
657315000734	catalytic residues [active]
657315000735	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
657315000736	MarR family; Region: MarR; pfam01047
657315000737	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315000738	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315000739	dimer interface [polypeptide binding]; other site
657315000740	phosphorylation site [posttranslational modification]
657315000741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315000742	ATP binding site [chemical binding]; other site
657315000743	Mg2+ binding site [ion binding]; other site
657315000744	G-X-G motif; other site
657315000745	Response regulator receiver domain; Region: Response_reg; pfam00072
657315000746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315000747	active site
657315000748	phosphorylation site [posttranslational modification]
657315000749	intermolecular recognition site; other site
657315000750	dimerization interface [polypeptide binding]; other site
657315000751	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315000752	non-specific DNA binding site [nucleotide binding]; other site
657315000753	salt bridge; other site
657315000754	sequence-specific DNA binding site [nucleotide binding]; other site
657315000755	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657315000756	Major Facilitator Superfamily; Region: MFS_1; pfam07690
657315000757	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315000758	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657315000759	DNA binding site [nucleotide binding]
657315000760	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657315000761	dimerization interface [polypeptide binding]; other site
657315000762	ligand binding site [chemical binding]; other site
657315000763	4-alpha-glucanotransferase; Provisional; Region: PRK14508
657315000764	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315000765	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315000766	dimer interface [polypeptide binding]; other site
657315000767	conserved gate region; other site
657315000768	putative PBP binding loops; other site
657315000769	ABC-ATPase subunit interface; other site
657315000770	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
657315000771	Ca binding site [ion binding]; other site
657315000772	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
657315000773	active site
657315000774	catalytic site [active]
657315000775	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
657315000776	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
657315000777	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
657315000778	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
657315000779	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315000780	Walker A/P-loop; other site
657315000781	ATP binding site [chemical binding]; other site
657315000782	Q-loop/lid; other site
657315000783	ABC transporter signature motif; other site
657315000784	Walker B; other site
657315000785	D-loop; other site
657315000786	H-loop/switch region; other site
657315000787	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
657315000788	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
657315000789	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
657315000790	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315000791	active site
657315000792	DNA binding site [nucleotide binding]
657315000793	Int/Topo IB signature motif; other site
657315000794	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315000795	non-specific DNA binding site [nucleotide binding]; other site
657315000796	salt bridge; other site
657315000797	sequence-specific DNA binding site [nucleotide binding]; other site
657315000798	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315000799	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315000800	non-specific DNA binding site [nucleotide binding]; other site
657315000801	salt bridge; other site
657315000802	sequence-specific DNA binding site [nucleotide binding]; other site
657315000803	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315000804	non-specific DNA binding site [nucleotide binding]; other site
657315000805	salt bridge; other site
657315000806	sequence-specific DNA binding site [nucleotide binding]; other site
657315000807	Protein of unknown function (DUF2398); Region: DUF2398; pfam09661
657315000808	TIGR02680 family protein; Region: TIGR02680
657315000809	P-loop containing region of AAA domain; Region: AAA_29; cl17516
657315000810	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
657315000811	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
657315000812	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315000813	dimerization interface [polypeptide binding]; other site
657315000814	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315000815	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315000816	dimer interface [polypeptide binding]; other site
657315000817	putative CheW interface [polypeptide binding]; other site
657315000818	Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749
657315000819	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
657315000820	substrate binding site [chemical binding]; other site
657315000821	Peptidase family C69; Region: Peptidase_C69; pfam03577
657315000822	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
657315000823	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
657315000824	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
657315000825	substrate binding site [chemical binding]; other site
657315000826	ATP binding site [chemical binding]; other site
657315000827	Uncharacterized conserved protein [Function unknown]; Region: COG1284
657315000828	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
657315000829	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
657315000830	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657315000831	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657315000832	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657315000833	dimerization interface [polypeptide binding]; other site
657315000834	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
657315000835	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
657315000836	Walker A/P-loop; other site
657315000837	ATP binding site [chemical binding]; other site
657315000838	Q-loop/lid; other site
657315000839	ABC transporter signature motif; other site
657315000840	Walker B; other site
657315000841	D-loop; other site
657315000842	H-loop/switch region; other site
657315000843	NIL domain; Region: NIL; pfam09383
657315000844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315000845	dimer interface [polypeptide binding]; other site
657315000846	conserved gate region; other site
657315000847	ABC-ATPase subunit interface; other site
657315000848	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
657315000849	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
657315000850	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
657315000851	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
657315000852	Flagellin N-methylase; Region: FliB; pfam03692
657315000853	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
657315000854	LrgB-like family; Region: LrgB; pfam04172
657315000855	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
657315000856	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
657315000857	mannonate dehydratase; Provisional; Region: PRK03906
657315000858	mannonate dehydratase; Region: uxuA; TIGR00695
657315000859	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657315000860	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657315000861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893
657315000862	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315000863	MFS/sugar transport protein; Region: MFS_2; pfam13347
657315000864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657315000865	putative substrate translocation pore; other site
657315000866	Creatinine amidohydrolase; Region: Creatininase; cl00618
657315000867	Cupin domain; Region: Cupin_2; pfam07883
657315000868	Helix-turn-helix domain; Region: HTH_18; pfam12833
657315000869	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315000870	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
657315000871	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
657315000872	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
657315000873	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
657315000874	putative active site [active]
657315000875	putative metal binding site [ion binding]; other site
657315000876	aspartate kinase; Reviewed; Region: PRK09034
657315000877	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
657315000878	nucleotide binding site [chemical binding]; other site
657315000879	substrate binding site [chemical binding]; other site
657315000880	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
657315000881	allosteric regulatory residue; other site
657315000882	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
657315000883	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
657315000884	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
657315000885	NAD binding site [chemical binding]; other site
657315000886	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
657315000887	TSCPD domain; Region: TSCPD; cl14834
657315000888	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
657315000889	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
657315000890	ATP binding site [chemical binding]; other site
657315000891	putative Mg++ binding site [ion binding]; other site
657315000892	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
657315000893	SEC-C motif; Region: SEC-C; pfam02810
657315000894	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
657315000895	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
657315000896	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
657315000897	excinuclease ABC subunit B; Provisional; Region: PRK05298
657315000898	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
657315000899	ATP binding site [chemical binding]; other site
657315000900	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
657315000901	nucleotide binding region [chemical binding]; other site
657315000902	ATP-binding site [chemical binding]; other site
657315000903	Ultra-violet resistance protein B; Region: UvrB; pfam12344
657315000904	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
657315000905	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
657315000906	Acyltransferase family; Region: Acyl_transf_3; pfam01757
657315000907	rod shape-determining protein Mbl; Provisional; Region: PRK13928
657315000908	MreB and similar proteins; Region: MreB_like; cd10225
657315000909	nucleotide binding site [chemical binding]; other site
657315000910	Mg binding site [ion binding]; other site
657315000911	putative protofilament interaction site [polypeptide binding]; other site
657315000912	RodZ interaction site [polypeptide binding]; other site
657315000913	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818
657315000914	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
657315000915	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
657315000916	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
657315000917	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
657315000918	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
657315000919	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
657315000920	AAA domain; Region: AAA_30; pfam13604
657315000921	Family description; Region: UvrD_C_2; pfam13538
657315000922	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
657315000923	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315000924	Walker A/P-loop; other site
657315000925	ATP binding site [chemical binding]; other site
657315000926	Q-loop/lid; other site
657315000927	ABC transporter signature motif; other site
657315000928	Walker B; other site
657315000929	D-loop; other site
657315000930	H-loop/switch region; other site
657315000931	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
657315000932	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
657315000933	TM-ABC transporter signature motif; other site
657315000934	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
657315000935	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657315000936	zinc binding site [ion binding]; other site
657315000937	putative ligand binding site [chemical binding]; other site
657315000938	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
657315000939	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657315000940	active site
657315000941	flagellar operon protein TIGR03826; Region: YvyF
657315000942	Transposase; Region: HTH_Tnp_1; cl17663
657315000943	YibE/F-like protein; Region: YibE_F; cl02259
657315000944	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
657315000945	YbbR-like protein; Region: YbbR; pfam07949
657315000946	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
657315000947	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
657315000948	active site
657315000949	substrate binding site [chemical binding]; other site
657315000950	metal binding site [ion binding]; metal-binding site
657315000951	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
657315000952	dimerization domain swap beta strand [polypeptide binding]; other site
657315000953	regulatory protein interface [polypeptide binding]; other site
657315000954	active site
657315000955	regulatory phosphorylation site [posttranslational modification]; other site
657315000956	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
657315000957	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
657315000958	NADP binding site [chemical binding]; other site
657315000959	active site
657315000960	putative substrate binding site [chemical binding]; other site
657315000961	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
657315000962	Protein of unknown function (DUF998); Region: DUF998; pfam06197
657315000963	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
657315000964	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
657315000965	NAD binding site [chemical binding]; other site
657315000966	substrate binding site [chemical binding]; other site
657315000967	homodimer interface [polypeptide binding]; other site
657315000968	active site
657315000969	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
657315000970	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
657315000971	substrate binding site; other site
657315000972	tetramer interface; other site
657315000973	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
657315000974	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
657315000975	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
657315000976	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
657315000977	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
657315000978	Walker A/P-loop; other site
657315000979	ATP binding site [chemical binding]; other site
657315000980	Q-loop/lid; other site
657315000981	ABC transporter signature motif; other site
657315000982	Walker B; other site
657315000983	D-loop; other site
657315000984	H-loop/switch region; other site
657315000985	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
657315000986	putative carbohydrate binding site [chemical binding]; other site
657315000987	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
657315000988	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
657315000989	Bacterial sugar transferase; Region: Bac_transf; pfam02397
657315000990	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
657315000991	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
657315000992	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
657315000993	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
657315000994	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
657315000995	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
657315000996	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
657315000997	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
657315000998	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
657315000999	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
657315001000	NAD(P) binding site [chemical binding]; other site
657315001001	active site
657315001002	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
657315001003	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657315001004	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
657315001005	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657315001006	active site
657315001007	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657315001008	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
657315001009	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
657315001010	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657315001011	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
657315001012	Bacterial sugar transferase; Region: Bac_transf; pfam02397
657315001013	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
657315001014	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
657315001015	active site
657315001016	metal binding site [ion binding]; metal-binding site
657315001017	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657315001018	Interdomain contacts; other site
657315001019	Cytokine receptor motif; other site
657315001020	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657315001021	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
657315001022	Interdomain contacts; other site
657315001023	Cytokine receptor motif; other site
657315001024	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657315001025	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657315001026	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
657315001027	Interdomain contacts; other site
657315001028	Cytokine receptor motif; other site
657315001029	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
657315001030	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657315001031	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657315001032	active site
657315001033	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657315001034	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
657315001035	LicD family; Region: LicD; pfam04991
657315001036	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
657315001037	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
657315001038	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
657315001039	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
657315001040	Walker A/P-loop; other site
657315001041	ATP binding site [chemical binding]; other site
657315001042	Q-loop/lid; other site
657315001043	ABC transporter signature motif; other site
657315001044	Walker B; other site
657315001045	D-loop; other site
657315001046	H-loop/switch region; other site
657315001047	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
657315001048	substrate binding site; other site
657315001049	dimer interface; other site
657315001050	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
657315001051	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
657315001052	NAD(P) binding site [chemical binding]; other site
657315001053	active site
657315001054	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
657315001055	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
657315001056	Right handed beta helix region; Region: Beta_helix; pfam13229
657315001057	Right handed beta helix region; Region: Beta_helix; pfam13229
657315001058	Transposase [DNA replication, recombination, and repair]; Region: COG5421
657315001059	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
657315001060	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
657315001061	NAD(P) binding site [chemical binding]; other site
657315001062	homodimer interface [polypeptide binding]; other site
657315001063	substrate binding site [chemical binding]; other site
657315001064	active site
657315001065	AAA domain; Region: AAA_21; pfam13304
657315001066	AAA domain; Region: AAA_21; pfam13304
657315001067	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315001068	Walker A/P-loop; other site
657315001069	ATP binding site [chemical binding]; other site
657315001070	Q-loop/lid; other site
657315001071	ABC transporter signature motif; other site
657315001072	Walker B; other site
657315001073	D-loop; other site
657315001074	H-loop/switch region; other site
657315001075	Bacterial sugar transferase; Region: Bac_transf; pfam02397
657315001076	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
657315001077	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
657315001078	NAD(P) binding site [chemical binding]; other site
657315001079	active site
657315001080	Predicted ATPases [General function prediction only]; Region: COG1106
657315001081	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
657315001082	putative ADP-binding pocket [chemical binding]; other site
657315001083	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
657315001084	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
657315001085	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
657315001086	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
657315001087	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
657315001088	Walker A/P-loop; other site
657315001089	ATP binding site [chemical binding]; other site
657315001090	Q-loop/lid; other site
657315001091	ABC transporter signature motif; other site
657315001092	Walker B; other site
657315001093	D-loop; other site
657315001094	H-loop/switch region; other site
657315001095	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
657315001096	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
657315001097	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
657315001098	Ligand binding site; other site
657315001099	metal-binding site
657315001100	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
657315001101	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
657315001102	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
657315001103	Ligand binding site; other site
657315001104	metal-binding site
657315001105	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
657315001106	active site
657315001107	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657315001108	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
657315001109	active site
657315001110	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
657315001111	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315001112	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
657315001113	active site
657315001114	motif I; other site
657315001115	motif II; other site
657315001116	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657315001117	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
657315001118	Ligand binding site; other site
657315001119	Putative Catalytic site; other site
657315001120	DXD motif; other site
657315001121	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657315001122	active site
657315001123	AAA domain; Region: AAA_21; pfam13304
657315001124	AAA domain; Region: AAA_31; pfam13614
657315001125	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657315001126	P-loop; other site
657315001127	Magnesium ion binding site [ion binding]; other site
657315001128	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657315001129	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
657315001130	active site
657315001131	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
657315001132	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
657315001133	Ligand binding site; other site
657315001134	Putative Catalytic site; other site
657315001135	DXD motif; other site
657315001136	Transposase; Region: HTH_Tnp_1; cl17663
657315001137	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
657315001138	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
657315001139	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
657315001140	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
657315001141	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
657315001142	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
657315001143	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
657315001144	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
657315001145	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
657315001146	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315001147	non-specific DNA binding site [nucleotide binding]; other site
657315001148	salt bridge; other site
657315001149	sequence-specific DNA binding site [nucleotide binding]; other site
657315001150	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
657315001151	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
657315001152	putative dimer interface [polypeptide binding]; other site
657315001153	catalytic triad [active]
657315001154	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
657315001155	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
657315001156	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
657315001157	active site
657315001158	nucleophile elbow; other site
657315001159	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
657315001160	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
657315001161	putative ligand binding site [chemical binding]; other site
657315001162	putative NAD binding site [chemical binding]; other site
657315001163	catalytic site [active]
657315001164	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
657315001165	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
657315001166	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315001167	FeS/SAM binding site; other site
657315001168	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
657315001169	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
657315001170	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
657315001171	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
657315001172	nucleotide binding site [chemical binding]; other site
657315001173	Type III pantothenate kinase; Region: Pan_kinase; cl17198
657315001174	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
657315001175	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
657315001176	FMN binding site [chemical binding]; other site
657315001177	active site
657315001178	catalytic residues [active]
657315001179	substrate binding site [chemical binding]; other site
657315001180	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
657315001181	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
657315001182	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
657315001183	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
657315001184	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
657315001185	dimer interface [polypeptide binding]; other site
657315001186	putative anticodon binding site; other site
657315001187	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
657315001188	motif 1; other site
657315001189	active site
657315001190	motif 2; other site
657315001191	motif 3; other site
657315001192	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
657315001193	dimer interface [polypeptide binding]; other site
657315001194	putative tRNA-binding site [nucleotide binding]; other site
657315001195	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
657315001196	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
657315001197	DNA binding residues [nucleotide binding]
657315001198	dimer interface [polypeptide binding]; other site
657315001199	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
657315001200	Putative transposase; Region: Y2_Tnp; pfam04986
657315001201	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
657315001202	Domain of unknown function (DUF955); Region: DUF955; pfam06114
657315001203	YodL-like; Region: YodL; pfam14191
657315001204	Predicted membrane protein [Function unknown]; Region: COG2364
657315001205	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
657315001206	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657315001207	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
657315001208	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
657315001209	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
657315001210	oxyanion hole [active]
657315001211	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
657315001212	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
657315001213	active site
657315001214	catalytic site [active]
657315001215	Predicted transcriptional regulator [Transcription]; Region: COG2378
657315001216	WYL domain; Region: WYL; pfam13280
657315001217	Transposase; Region: DEDD_Tnp_IS110; pfam01548
657315001218	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
657315001219	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
657315001220	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
657315001221	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
657315001222	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
657315001223	active site
657315001224	hypothetical protein; Validated; Region: PRK00124
657315001225	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
657315001226	putative ADP-ribose binding site [chemical binding]; other site
657315001227	putative active site [active]
657315001228	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
657315001229	dimer interface [polypeptide binding]; other site
657315001230	putative tRNA-binding site [nucleotide binding]; other site
657315001231	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
657315001232	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
657315001233	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
657315001234	putative active site [active]
657315001235	catalytic site [active]
657315001236	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
657315001237	putative active site [active]
657315001238	catalytic site [active]
657315001239	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
657315001240	dimer interface [polypeptide binding]; other site
657315001241	Citrate synthase; Region: Citrate_synt; pfam00285
657315001242	active site
657315001243	citrylCoA binding site [chemical binding]; other site
657315001244	oxalacetate/citrate binding site [chemical binding]; other site
657315001245	coenzyme A binding site [chemical binding]; other site
657315001246	catalytic triad [active]
657315001247	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
657315001248	MarR family; Region: MarR_2; pfam12802
657315001249	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
657315001250	PLD-like domain; Region: PLDc_2; pfam13091
657315001251	putative active site [active]
657315001252	catalytic site [active]
657315001253	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
657315001254	PLD-like domain; Region: PLDc_2; pfam13091
657315001255	putative active site [active]
657315001256	catalytic site [active]
657315001257	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315001258	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315001259	dimerization interface [polypeptide binding]; other site
657315001260	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315001261	dimer interface [polypeptide binding]; other site
657315001262	phosphorylation site [posttranslational modification]
657315001263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315001264	ATP binding site [chemical binding]; other site
657315001265	Mg2+ binding site [ion binding]; other site
657315001266	G-X-G motif; other site
657315001267	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
657315001268	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
657315001269	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
657315001270	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
657315001271	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
657315001272	active site
657315001273	FtsH Extracellular; Region: FtsH_ext; pfam06480
657315001274	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
657315001275	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
657315001276	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315001277	Walker A motif; other site
657315001278	ATP binding site [chemical binding]; other site
657315001279	Walker B motif; other site
657315001280	arginine finger; other site
657315001281	Peptidase family M41; Region: Peptidase_M41; pfam01434
657315001282	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
657315001283	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
657315001284	Walker A/P-loop; other site
657315001285	ATP binding site [chemical binding]; other site
657315001286	Q-loop/lid; other site
657315001287	ABC transporter signature motif; other site
657315001288	Walker B; other site
657315001289	D-loop; other site
657315001290	H-loop/switch region; other site
657315001291	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
657315001292	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
657315001293	lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733
657315001294	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
657315001295	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315001296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315001297	active site
657315001298	phosphorylation site [posttranslational modification]
657315001299	intermolecular recognition site; other site
657315001300	dimerization interface [polypeptide binding]; other site
657315001301	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315001302	DNA binding site [nucleotide binding]
657315001303	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315001304	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315001305	dimer interface [polypeptide binding]; other site
657315001306	phosphorylation site [posttranslational modification]
657315001307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315001308	ATP binding site [chemical binding]; other site
657315001309	Mg2+ binding site [ion binding]; other site
657315001310	G-X-G motif; other site
657315001311	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
657315001312	AAA domain; Region: AAA_14; pfam13173
657315001313	MFS/sugar transport protein; Region: MFS_2; pfam13347
657315001314	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657315001315	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
657315001316	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
657315001317	active site
657315001318	FMN binding site [chemical binding]; other site
657315001319	substrate binding site [chemical binding]; other site
657315001320	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
657315001321	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
657315001322	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315001323	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315001324	active site
657315001325	phosphorylation site [posttranslational modification]
657315001326	intermolecular recognition site; other site
657315001327	dimerization interface [polypeptide binding]; other site
657315001328	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315001329	DNA binding site [nucleotide binding]
657315001330	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315001331	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315001332	ATP binding site [chemical binding]; other site
657315001333	Mg2+ binding site [ion binding]; other site
657315001334	G-X-G motif; other site
657315001335	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657315001336	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657315001337	Walker A/P-loop; other site
657315001338	ATP binding site [chemical binding]; other site
657315001339	Q-loop/lid; other site
657315001340	ABC transporter signature motif; other site
657315001341	Walker B; other site
657315001342	D-loop; other site
657315001343	H-loop/switch region; other site
657315001344	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657315001345	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
657315001346	FtsX-like permease family; Region: FtsX; pfam02687
657315001347	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657315001348	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
657315001349	FtsX-like permease family; Region: FtsX; pfam02687
657315001350	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
657315001351	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315001352	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315001353	metal binding site [ion binding]; metal-binding site
657315001354	active site
657315001355	I-site; other site
657315001356	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
657315001357	PAS fold; Region: PAS_3; pfam08447
657315001358	putative active site [active]
657315001359	heme pocket [chemical binding]; other site
657315001360	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315001361	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234
657315001362	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315001363	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657315001364	DNA binding site [nucleotide binding]
657315001365	domain linker motif; other site
657315001366	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657315001367	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657315001368	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315001369	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
657315001370	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
657315001371	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
657315001372	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315001373	Walker A/P-loop; other site
657315001374	ATP binding site [chemical binding]; other site
657315001375	Q-loop/lid; other site
657315001376	ABC transporter signature motif; other site
657315001377	Walker B; other site
657315001378	D-loop; other site
657315001379	H-loop/switch region; other site
657315001380	TOBE domain; Region: TOBE_2; pfam08402
657315001381	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
657315001382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315001383	dimer interface [polypeptide binding]; other site
657315001384	conserved gate region; other site
657315001385	putative PBP binding loops; other site
657315001386	ABC-ATPase subunit interface; other site
657315001387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315001388	dimer interface [polypeptide binding]; other site
657315001389	conserved gate region; other site
657315001390	putative PBP binding loops; other site
657315001391	ABC-ATPase subunit interface; other site
657315001392	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
657315001393	putative active site [active]
657315001394	catalytic site [active]
657315001395	putative metal binding site [ion binding]; other site
657315001396	oligomer interface [polypeptide binding]; other site
657315001397	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
657315001398	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
657315001399	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
657315001400	MgtC family; Region: MgtC; pfam02308
657315001401	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
657315001402	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
657315001403	active site
657315001404	catalytic site [active]
657315001405	metal binding site [ion binding]; metal-binding site
657315001406	dimer interface [polypeptide binding]; other site
657315001407	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
657315001408	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
657315001409	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315001410	non-specific DNA binding site [nucleotide binding]; other site
657315001411	salt bridge; other site
657315001412	sequence-specific DNA binding site [nucleotide binding]; other site
657315001413	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234
657315001414	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315001415	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315001416	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315001417	Walker A/P-loop; other site
657315001418	ATP binding site [chemical binding]; other site
657315001419	Q-loop/lid; other site
657315001420	ABC transporter signature motif; other site
657315001421	Walker B; other site
657315001422	D-loop; other site
657315001423	H-loop/switch region; other site
657315001424	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315001425	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315001426	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315001427	Walker A/P-loop; other site
657315001428	ATP binding site [chemical binding]; other site
657315001429	Q-loop/lid; other site
657315001430	ABC transporter signature motif; other site
657315001431	Walker B; other site
657315001432	D-loop; other site
657315001433	H-loop/switch region; other site
657315001434	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315001435	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
657315001436	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
657315001437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315001438	dimer interface [polypeptide binding]; other site
657315001439	conserved gate region; other site
657315001440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
657315001441	ABC-ATPase subunit interface; other site
657315001442	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315001443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315001444	dimer interface [polypeptide binding]; other site
657315001445	conserved gate region; other site
657315001446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
657315001447	ABC-ATPase subunit interface; other site
657315001448	Histidine kinase; Region: His_kinase; pfam06580
657315001449	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
657315001450	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
657315001451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315001452	active site
657315001453	phosphorylation site [posttranslational modification]
657315001454	intermolecular recognition site; other site
657315001455	dimerization interface [polypeptide binding]; other site
657315001456	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315001457	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
657315001458	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
657315001459	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
657315001460	Sulfatase; Region: Sulfatase; pfam00884
657315001461	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
657315001462	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
657315001463	active site
657315001464	catalytic tetrad [active]
657315001465	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
657315001466	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
657315001467	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315001468	motif II; other site
657315001469	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
657315001470	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
657315001471	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
657315001472	putative ATP binding site [chemical binding]; other site
657315001473	putative substrate interface [chemical binding]; other site
657315001474	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
657315001475	peptide binding site [polypeptide binding]; other site
657315001476	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
657315001477	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
657315001478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315001479	dimer interface [polypeptide binding]; other site
657315001480	conserved gate region; other site
657315001481	putative PBP binding loops; other site
657315001482	ABC-ATPase subunit interface; other site
657315001483	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
657315001484	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
657315001485	Walker A/P-loop; other site
657315001486	ATP binding site [chemical binding]; other site
657315001487	Q-loop/lid; other site
657315001488	ABC transporter signature motif; other site
657315001489	Walker B; other site
657315001490	D-loop; other site
657315001491	H-loop/switch region; other site
657315001492	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
657315001493	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
657315001494	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
657315001495	Walker A/P-loop; other site
657315001496	ATP binding site [chemical binding]; other site
657315001497	Q-loop/lid; other site
657315001498	ABC transporter signature motif; other site
657315001499	Walker B; other site
657315001500	D-loop; other site
657315001501	H-loop/switch region; other site
657315001502	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
657315001503	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315001504	dimerization interface [polypeptide binding]; other site
657315001505	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315001506	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315001507	dimer interface [polypeptide binding]; other site
657315001508	putative CheW interface [polypeptide binding]; other site
657315001509	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
657315001510	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
657315001511	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
657315001512	Na2 binding site [ion binding]; other site
657315001513	putative substrate binding site 1 [chemical binding]; other site
657315001514	Na binding site 1 [ion binding]; other site
657315001515	putative substrate binding site 2 [chemical binding]; other site
657315001516	Domain of unknown function (DUF4317); Region: DUF4317; pfam14199
657315001517	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315001518	Zn2+ binding site [ion binding]; other site
657315001519	Mg2+ binding site [ion binding]; other site
657315001520	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
657315001521	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315001522	Zn2+ binding site [ion binding]; other site
657315001523	Mg2+ binding site [ion binding]; other site
657315001524	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
657315001525	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
657315001526	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
657315001527	HAMP domain; Region: HAMP; pfam00672
657315001528	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315001529	dimer interface [polypeptide binding]; other site
657315001530	putative CheW interface [polypeptide binding]; other site
657315001531	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760
657315001532	heme-binding site [chemical binding]; other site
657315001533	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
657315001534	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
657315001535	intersubunit interface [polypeptide binding]; other site
657315001536	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
657315001537	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
657315001538	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
657315001539	ABC-ATPase subunit  interface; other site
657315001540	dimer interface [polypeptide binding]; other site
657315001541	putative PBP binding regions; other site
657315001542	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
657315001543	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
657315001544	Walker A/P-loop; other site
657315001545	ATP binding site [chemical binding]; other site
657315001546	Q-loop/lid; other site
657315001547	ABC transporter signature motif; other site
657315001548	Walker B; other site
657315001549	D-loop; other site
657315001550	H-loop/switch region; other site
657315001551	Part of AAA domain; Region: AAA_19; pfam13245
657315001552	AAA domain; Region: AAA_11; pfam13086
657315001553	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
657315001554	AAA domain; Region: AAA_12; pfam13087
657315001555	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
657315001556	Transcriptional regulators [Transcription]; Region: FadR; COG2186
657315001557	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657315001558	DNA-binding site [nucleotide binding]; DNA binding site
657315001559	FCD domain; Region: FCD; pfam07729
657315001560	fructuronate transporter; Provisional; Region: PRK10034; cl15264
657315001561	GntP family permease; Region: GntP_permease; pfam02447
657315001562	Dehydratase family; Region: ILVD_EDD; pfam00920
657315001563	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315001564	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315001565	non-specific DNA binding site [nucleotide binding]; other site
657315001566	salt bridge; other site
657315001567	sequence-specific DNA binding site [nucleotide binding]; other site
657315001568	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
657315001569	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
657315001570	nucleotide binding site [chemical binding]; other site
657315001571	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
657315001572	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
657315001573	active site
657315001574	trimer interface [polypeptide binding]; other site
657315001575	allosteric site; other site
657315001576	active site lid [active]
657315001577	hexamer (dimer of trimers) interface [polypeptide binding]; other site
657315001578	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
657315001579	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
657315001580	active site
657315001581	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095
657315001582	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
657315001583	active site
657315001584	dimer interface [polypeptide binding]; other site
657315001585	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
657315001586	dimer interface [polypeptide binding]; other site
657315001587	active site
657315001588	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
657315001589	MraW methylase family; Region: Methyltransf_5; cl17771
657315001590	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
657315001591	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
657315001592	active site
657315001593	multimer interface [polypeptide binding]; other site
657315001594	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315001595	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
657315001596	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
657315001597	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
657315001598	active site
657315001599	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657315001600	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657315001601	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
657315001602	putative dimerization interface [polypeptide binding]; other site
657315001603	Predicted membrane protein [Function unknown]; Region: COG2364
657315001604	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
657315001605	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
657315001606	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
657315001607	PA/protease or protease-like domain interface [polypeptide binding]; other site
657315001608	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
657315001609	Peptidase family M28; Region: Peptidase_M28; pfam04389
657315001610	metal binding site [ion binding]; metal-binding site
657315001611	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
657315001612	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657315001613	Coenzyme A binding pocket [chemical binding]; other site
657315001614	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
657315001615	FlgN protein; Region: FlgN; pfam05130
657315001616	Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256
657315001617	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
657315001618	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
657315001619	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
657315001620	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
657315001621	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
657315001622	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
657315001623	FliW protein; Region: FliW; cl00740
657315001624	Global regulator protein family; Region: CsrA; pfam02599
657315001625	FlaG protein; Region: FlaG; pfam03646
657315001626	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
657315001627	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
657315001628	Flagellar protein FliS; Region: FliS; cl00654
657315001629	flagellin; Provisional; Region: PRK12804
657315001630	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
657315001631	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
657315001632	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
657315001633	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
657315001634	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
657315001635	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
657315001636	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
657315001637	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
657315001638	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
657315001639	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657315001640	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
657315001641	active site
657315001642	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
657315001643	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
657315001644	Probable Catalytic site; other site
657315001645	metal-binding site
657315001646	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315001647	S-adenosylmethionine binding site [chemical binding]; other site
657315001648	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
657315001649	active site
657315001650	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
657315001651	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657315001652	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
657315001653	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
657315001654	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
657315001655	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
657315001656	Ligand binding site; other site
657315001657	metal-binding site
657315001658	WxcM-like, C-terminal; Region: FdtA; pfam05523
657315001659	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
657315001660	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
657315001661	active site
657315001662	substrate binding site [chemical binding]; other site
657315001663	cosubstrate binding site; other site
657315001664	catalytic site [active]
657315001665	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
657315001666	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657315001667	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
657315001668	active site
657315001669	Domain of unknown function (DUF1919); Region: DUF1919; cl01628
657315001670	LicD family; Region: LicD; cl01378
657315001671	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
657315001672	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
657315001673	active site
657315001674	metal-binding site
657315001675	BCCT family transporter; Region: BCCT; pfam02028
657315001676	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
657315001677	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
657315001678	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
657315001679	flagellin; Provisional; Region: PRK12804
657315001680	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
657315001681	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
657315001682	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
657315001683	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
657315001684	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
657315001685	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657315001686	putative metal binding site; other site
657315001687	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
657315001688	TPR motif; other site
657315001689	binding surface
657315001690	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
657315001691	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
657315001692	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
657315001693	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
657315001694	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
657315001695	flagellar capping protein; Provisional; Region: PRK12765
657315001696	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
657315001697	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
657315001698	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
657315001699	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
657315001700	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
657315001701	putative homodimer interface [polypeptide binding]; other site
657315001702	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
657315001703	heterodimer interface [polypeptide binding]; other site
657315001704	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
657315001705	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
657315001706	23S rRNA interface [nucleotide binding]; other site
657315001707	L7/L12 interface [polypeptide binding]; other site
657315001708	putative thiostrepton binding site; other site
657315001709	L25 interface [polypeptide binding]; other site
657315001710	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
657315001711	mRNA/rRNA interface [nucleotide binding]; other site
657315001712	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
657315001713	core dimer interface [polypeptide binding]; other site
657315001714	peripheral dimer interface [polypeptide binding]; other site
657315001715	L10 interface [polypeptide binding]; other site
657315001716	L11 interface [polypeptide binding]; other site
657315001717	putative EF-Tu interaction site [polypeptide binding]; other site
657315001718	putative EF-G interaction site [polypeptide binding]; other site
657315001719	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
657315001720	Flavoprotein; Region: Flavoprotein; pfam02441
657315001721	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
657315001722	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
657315001723	ligand binding site [chemical binding]; other site
657315001724	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
657315001725	active site residue [active]
657315001726	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
657315001727	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
657315001728	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
657315001729	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
657315001730	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
657315001731	active site
657315001732	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
657315001733	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
657315001734	active site
657315001735	metal binding site [ion binding]; metal-binding site
657315001736	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
657315001737	active site
657315001738	dimerization interface [polypeptide binding]; other site
657315001739	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
657315001740	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
657315001741	active site
657315001742	metal binding site [ion binding]; metal-binding site
657315001743	homotetramer interface [polypeptide binding]; other site
657315001744	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
657315001745	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310
657315001746	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
657315001747	PDGLE domain; Region: PDGLE; pfam13190
657315001748	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
657315001749	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
657315001750	Walker A/P-loop; other site
657315001751	ATP binding site [chemical binding]; other site
657315001752	Q-loop/lid; other site
657315001753	ABC transporter signature motif; other site
657315001754	Walker B; other site
657315001755	D-loop; other site
657315001756	H-loop/switch region; other site
657315001757	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
657315001758	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315001759	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315001760	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315001761	dimer interface [polypeptide binding]; other site
657315001762	putative CheW interface [polypeptide binding]; other site
657315001763	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315001764	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315001765	dimer interface [polypeptide binding]; other site
657315001766	putative CheW interface [polypeptide binding]; other site
657315001767	PilZ domain; Region: PilZ; pfam07238
657315001768	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
657315001769	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
657315001770	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
657315001771	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315001772	dimer interface [polypeptide binding]; other site
657315001773	conserved gate region; other site
657315001774	putative PBP binding loops; other site
657315001775	ABC-ATPase subunit interface; other site
657315001776	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
657315001777	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
657315001778	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
657315001779	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
657315001780	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
657315001781	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
657315001782	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315001783	dimer interface [polypeptide binding]; other site
657315001784	conserved gate region; other site
657315001785	putative PBP binding loops; other site
657315001786	ABC-ATPase subunit interface; other site
657315001787	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
657315001788	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
657315001789	Walker A/P-loop; other site
657315001790	ATP binding site [chemical binding]; other site
657315001791	Q-loop/lid; other site
657315001792	ABC transporter signature motif; other site
657315001793	Walker B; other site
657315001794	D-loop; other site
657315001795	H-loop/switch region; other site
657315001796	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
657315001797	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315001798	Walker A/P-loop; other site
657315001799	ATP binding site [chemical binding]; other site
657315001800	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
657315001801	Q-loop/lid; other site
657315001802	ABC transporter signature motif; other site
657315001803	Walker B; other site
657315001804	D-loop; other site
657315001805	H-loop/switch region; other site
657315001806	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
657315001807	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
657315001808	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
657315001809	putative ligand binding site [chemical binding]; other site
657315001810	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
657315001811	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
657315001812	TM-ABC transporter signature motif; other site
657315001813	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
657315001814	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
657315001815	TM-ABC transporter signature motif; other site
657315001816	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
657315001817	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
657315001818	Walker A/P-loop; other site
657315001819	ATP binding site [chemical binding]; other site
657315001820	Q-loop/lid; other site
657315001821	ABC transporter signature motif; other site
657315001822	Walker B; other site
657315001823	D-loop; other site
657315001824	H-loop/switch region; other site
657315001825	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
657315001826	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
657315001827	Walker A/P-loop; other site
657315001828	ATP binding site [chemical binding]; other site
657315001829	Q-loop/lid; other site
657315001830	ABC transporter signature motif; other site
657315001831	Walker B; other site
657315001832	D-loop; other site
657315001833	H-loop/switch region; other site
657315001834	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
657315001835	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
657315001836	active site
657315001837	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
657315001838	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
657315001839	active site
657315001840	catalytic tetrad [active]
657315001841	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657315001842	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
657315001843	TrkA-N domain; Region: TrkA_N; pfam02254
657315001844	TrkA-C domain; Region: TrkA_C; pfam02080
657315001845	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
657315001846	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
657315001847	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
657315001848	Methyltransferase domain; Region: Methyltransf_32; pfam13679
657315001849	Methyltransferase domain; Region: Methyltransf_31; pfam13847
657315001850	Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761
657315001851	putative active site [active]
657315001852	putative metal binding residues [ion binding]; other site
657315001853	signature motif; other site
657315001854	putative dimer interface [polypeptide binding]; other site
657315001855	putative phosphate binding site [ion binding]; other site
657315001856	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
657315001857	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
657315001858	Predicted membrane protein [Function unknown]; Region: COG2246
657315001859	GtrA-like protein; Region: GtrA; pfam04138
657315001860	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
657315001861	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
657315001862	Ligand binding site; other site
657315001863	Putative Catalytic site; other site
657315001864	DXD motif; other site
657315001865	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
657315001866	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
657315001867	Ligand binding site; other site
657315001868	Putative Catalytic site; other site
657315001869	DXD motif; other site
657315001870	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
657315001871	Fn3 associated; Region: Fn3_assoc; pfam13287
657315001872	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
657315001873	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
657315001874	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
657315001875	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
657315001876	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
657315001877	Acyltransferase family; Region: Acyl_transf_3; pfam01757
657315001878	Acyltransferase family; Region: Acyl_transf_3; pfam01757
657315001879	Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304
657315001880	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
657315001881	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
657315001882	GDP-Fucose binding site [chemical binding]; other site
657315001883	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315001884	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
657315001885	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315001886	Walker A/P-loop; other site
657315001887	ATP binding site [chemical binding]; other site
657315001888	Q-loop/lid; other site
657315001889	ABC transporter signature motif; other site
657315001890	Walker B; other site
657315001891	D-loop; other site
657315001892	H-loop/switch region; other site
657315001893	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
657315001894	GDP-fucose protein O-fucosyltransferase; Region: O-FucT; pfam10250
657315001895	GDP-Fucose binding site [chemical binding]; other site
657315001896	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
657315001897	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
657315001898	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
657315001899	active site
657315001900	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
657315001901	dimer interface [polypeptide binding]; other site
657315001902	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
657315001903	Ligand Binding Site [chemical binding]; other site
657315001904	Molecular Tunnel; other site
657315001905	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
657315001906	Acyltransferase family; Region: Acyl_transf_3; pfam01757
657315001907	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315001908	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315001909	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315001910	Cupin domain; Region: Cupin_2; cl17218
657315001911	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
657315001912	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
657315001913	NADP-binding site; other site
657315001914	homotetramer interface [polypeptide binding]; other site
657315001915	substrate binding site [chemical binding]; other site
657315001916	homodimer interface [polypeptide binding]; other site
657315001917	active site
657315001918	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
657315001919	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
657315001920	NADP binding site [chemical binding]; other site
657315001921	active site
657315001922	putative substrate binding site [chemical binding]; other site
657315001923	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
657315001924	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657315001925	active site
657315001926	Cupin domain; Region: Cupin_2; cl17218
657315001927	Penicillinase repressor; Region: Pencillinase_R; cl17580
657315001928	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
657315001929	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
657315001930	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
657315001931	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
657315001932	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
657315001933	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
657315001934	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
657315001935	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657315001936	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
657315001937	Probable Catalytic site; other site
657315001938	metal-binding site
657315001939	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
657315001940	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
657315001941	Probable Catalytic site; other site
657315001942	metal-binding site
657315001943	methyl coenzyme M reductase system, component A2; Region: met_CoM_red_A2; TIGR03269
657315001944	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657315001945	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
657315001946	Probable Catalytic site; other site
657315001947	metal-binding site
657315001948	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
657315001949	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
657315001950	Probable Catalytic site; other site
657315001951	metal-binding site
657315001952	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
657315001953	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
657315001954	Probable Catalytic site; other site
657315001955	metal-binding site
657315001956	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
657315001957	Bacterial sugar transferase; Region: Bac_transf; pfam02397
657315001958	Transcriptional regulator [Transcription]; Region: LytR; COG1316
657315001959	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657315001960	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
657315001961	active site
657315001962	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
657315001963	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
657315001964	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
657315001965	protein binding site [polypeptide binding]; other site
657315001966	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
657315001967	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
657315001968	recombination factor protein RarA; Reviewed; Region: PRK13342
657315001969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315001970	Walker A motif; other site
657315001971	ATP binding site [chemical binding]; other site
657315001972	Walker B motif; other site
657315001973	arginine finger; other site
657315001974	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
657315001975	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
657315001976	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
657315001977	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657315001978	catalytic residue [active]
657315001979	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
657315001980	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
657315001981	Transcriptional regulators [Transcription]; Region: GntR; COG1802
657315001982	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657315001983	DNA-binding site [nucleotide binding]; DNA binding site
657315001984	FCD domain; Region: FCD; pfam07729
657315001985	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
657315001986	Spore germination protein; Region: Spore_permease; cl17796
657315001987	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
657315001988	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
657315001989	Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353
657315001990	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
657315001991	active site
657315001992	catalytic site [active]
657315001993	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
657315001994	pyrroline-5-carboxylate reductase; Region: PLN02688
657315001995	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315001996	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
657315001997	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657315001998	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315001999	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315002000	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
657315002001	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
657315002002	substrate binding site [chemical binding]; other site
657315002003	oxyanion hole (OAH) forming residues; other site
657315002004	trimer interface [polypeptide binding]; other site
657315002005	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
657315002006	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
657315002007	minor groove reading motif; other site
657315002008	helix-hairpin-helix signature motif; other site
657315002009	substrate binding pocket [chemical binding]; other site
657315002010	active site
657315002011	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
657315002012	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
657315002013	DNA binding and oxoG recognition site [nucleotide binding]
657315002014	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
657315002015	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
657315002016	UDP-galactopyranose mutase; Region: GLF; pfam03275
657315002017	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657315002018	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
657315002019	active site
657315002020	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
657315002021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315002022	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
657315002023	Walker A/P-loop; other site
657315002024	ATP binding site [chemical binding]; other site
657315002025	Q-loop/lid; other site
657315002026	ABC transporter signature motif; other site
657315002027	Walker B; other site
657315002028	D-loop; other site
657315002029	H-loop/switch region; other site
657315002030	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
657315002031	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
657315002032	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
657315002033	reactive center loop; other site
657315002034	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657315002035	active site
657315002036	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
657315002037	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
657315002038	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
657315002039	putative active site [active]
657315002040	putative metal binding site [ion binding]; other site
657315002041	Response regulator receiver domain; Region: Response_reg; pfam00072
657315002042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315002043	active site
657315002044	phosphorylation site [posttranslational modification]
657315002045	intermolecular recognition site; other site
657315002046	dimerization interface [polypeptide binding]; other site
657315002047	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315002048	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
657315002049	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
657315002050	active site
657315002051	PAS fold; Region: PAS_3; pfam08447
657315002052	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315002053	metal binding site [ion binding]; metal-binding site
657315002054	active site
657315002055	I-site; other site
657315002056	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
657315002057	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657315002058	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657315002059	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315002060	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315002061	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
657315002062	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
657315002063	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657315002064	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657315002065	Transcriptional regulator PadR-like family; Region: PadR; cl17335
657315002066	Predicted transcriptional regulators [Transcription]; Region: COG1695
657315002067	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
657315002068	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
657315002069	active site
657315002070	dimer interface [polypeptide binding]; other site
657315002071	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
657315002072	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
657315002073	substrate binding site [chemical binding]; other site
657315002074	ATP binding site [chemical binding]; other site
657315002075	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
657315002076	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
657315002077	substrate binding site [chemical binding]; other site
657315002078	ATP binding site [chemical binding]; other site
657315002079	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
657315002080	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315002081	active site
657315002082	DNA binding site [nucleotide binding]
657315002083	Int/Topo IB signature motif; other site
657315002084	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
657315002085	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
657315002086	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
657315002087	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
657315002088	Domain of unknown function (DUF4317); Region: DUF4317; pfam14199
657315002089	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
657315002090	active site
657315002091	catalytic triad [active]
657315002092	oxyanion hole [active]
657315002093	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
657315002094	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
657315002095	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
657315002096	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657315002097	Coenzyme A binding pocket [chemical binding]; other site
657315002098	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
657315002099	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
657315002100	HflX GTPase family; Region: HflX; cd01878
657315002101	G1 box; other site
657315002102	GTP/Mg2+ binding site [chemical binding]; other site
657315002103	Switch I region; other site
657315002104	G2 box; other site
657315002105	G3 box; other site
657315002106	Switch II region; other site
657315002107	G4 box; other site
657315002108	G5 box; other site
657315002109	dihydroorotase; Validated; Region: pyrC; PRK09357
657315002110	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
657315002111	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
657315002112	active site
657315002113	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
657315002114	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
657315002115	FAD binding pocket [chemical binding]; other site
657315002116	FAD binding motif [chemical binding]; other site
657315002117	phosphate binding motif [ion binding]; other site
657315002118	beta-alpha-beta structure motif; other site
657315002119	NAD binding pocket [chemical binding]; other site
657315002120	Iron coordination center [ion binding]; other site
657315002121	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
657315002122	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
657315002123	heterodimer interface [polypeptide binding]; other site
657315002124	active site
657315002125	FMN binding site [chemical binding]; other site
657315002126	homodimer interface [polypeptide binding]; other site
657315002127	substrate binding site [chemical binding]; other site
657315002128	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657315002129	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
657315002130	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
657315002131	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
657315002132	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315002133	Zn2+ binding site [ion binding]; other site
657315002134	Mg2+ binding site [ion binding]; other site
657315002135	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
657315002136	synthetase active site [active]
657315002137	NTP binding site [chemical binding]; other site
657315002138	metal binding site [ion binding]; metal-binding site
657315002139	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
657315002140	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
657315002141	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
657315002142	coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994
657315002143	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315002144	FeS/SAM binding site; other site
657315002145	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
657315002146	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657315002147	P-loop; other site
657315002148	Magnesium ion binding site [ion binding]; other site
657315002149	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
657315002150	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657315002151	Magnesium ion binding site [ion binding]; other site
657315002152	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
657315002153	ParB-like nuclease domain; Region: ParBc; pfam02195
657315002154	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
657315002155	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
657315002156	Recombinase; Region: Recombinase; pfam07508
657315002157	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315002158	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
657315002159	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657315002160	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
657315002161	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657315002162	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
657315002163	Walker A/P-loop; other site
657315002164	ATP binding site [chemical binding]; other site
657315002165	Q-loop/lid; other site
657315002166	ABC transporter signature motif; other site
657315002167	Walker B; other site
657315002168	D-loop; other site
657315002169	H-loop/switch region; other site
657315002170	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
657315002171	MobA/MobL family; Region: MobA_MobL; pfam03389
657315002172	CHC2 zinc finger; Region: zf-CHC2; cl17510
657315002173	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
657315002174	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
657315002175	active site
657315002176	metal binding site [ion binding]; metal-binding site
657315002177	interdomain interaction site; other site
657315002178	AAA domain; Region: AAA_25; pfam13481
657315002179	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657315002180	ATP binding site [chemical binding]; other site
657315002181	Walker A motif; other site
657315002182	Walker B motif; other site
657315002183	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
657315002184	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657315002185	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
657315002186	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315002187	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315002188	non-specific DNA binding site [nucleotide binding]; other site
657315002189	salt bridge; other site
657315002190	sequence-specific DNA binding site [nucleotide binding]; other site
657315002191	CHC2 zinc finger; Region: zf-CHC2; cl17510
657315002192	Virulence-associated protein E; Region: VirE; pfam05272
657315002193	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315002194	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
657315002195	putative catalytic residues [active]
657315002196	catalytic nucleophile [active]
657315002197	Recombinase; Region: Recombinase; pfam07508
657315002198	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315002199	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
657315002200	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
657315002201	FtsX-like permease family; Region: FtsX; pfam02687
657315002202	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
657315002203	FtsX-like permease family; Region: FtsX; pfam02687
657315002204	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657315002205	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657315002206	Walker A/P-loop; other site
657315002207	ATP binding site [chemical binding]; other site
657315002208	Q-loop/lid; other site
657315002209	ABC transporter signature motif; other site
657315002210	Walker B; other site
657315002211	D-loop; other site
657315002212	H-loop/switch region; other site
657315002213	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315002214	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315002215	dimer interface [polypeptide binding]; other site
657315002216	phosphorylation site [posttranslational modification]
657315002217	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315002218	ATP binding site [chemical binding]; other site
657315002219	Mg2+ binding site [ion binding]; other site
657315002220	G-X-G motif; other site
657315002221	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315002222	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315002223	active site
657315002224	phosphorylation site [posttranslational modification]
657315002225	intermolecular recognition site; other site
657315002226	dimerization interface [polypeptide binding]; other site
657315002227	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315002228	DNA binding site [nucleotide binding]
657315002229	Helix-turn-helix domain; Region: HTH_17; pfam12728
657315002230	Maff2 family; Region: Maff2; pfam12750
657315002231	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315002232	non-specific DNA binding site [nucleotide binding]; other site
657315002233	salt bridge; other site
657315002234	sequence-specific DNA binding site [nucleotide binding]; other site
657315002235	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
657315002236	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
657315002237	DNA binding residues [nucleotide binding]
657315002238	Helix-turn-helix domain; Region: HTH_16; pfam12645
657315002239	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
657315002240	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
657315002241	hypothetical protein; Validated; Region: PRK08116
657315002242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315002243	Walker A motif; other site
657315002244	ATP binding site [chemical binding]; other site
657315002245	Walker B motif; other site
657315002246	arginine finger; other site
657315002247	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
657315002248	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315002249	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
657315002250	putative catalytic residues [active]
657315002251	catalytic nucleophile [active]
657315002252	Recombinase; Region: Recombinase; pfam07508
657315002253	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315002254	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
657315002255	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657315002256	integrase; Provisional; Region: int; PHA02601
657315002257	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315002258	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
657315002259	Int/Topo IB signature motif; other site
657315002260	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315002261	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315002262	non-specific DNA binding site [nucleotide binding]; other site
657315002263	salt bridge; other site
657315002264	sequence-specific DNA binding site [nucleotide binding]; other site
657315002265	Helix-turn-helix domain; Region: HTH_17; cl17695
657315002266	MobA/MobL family; Region: MobA_MobL; pfam03389
657315002267	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657315002268	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657315002269	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315002270	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315002271	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
657315002272	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
657315002273	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
657315002274	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
657315002275	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
657315002276	MFS/sugar transport protein; Region: MFS_2; pfam13347
657315002277	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
657315002278	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657315002279	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657315002280	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315002281	Helix-turn-helix domain; Region: HTH_18; pfam12833
657315002282	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315002283	histidyl-tRNA synthetase; Region: hisS; TIGR00442
657315002284	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
657315002285	dimer interface [polypeptide binding]; other site
657315002286	motif 1; other site
657315002287	active site
657315002288	motif 2; other site
657315002289	motif 3; other site
657315002290	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
657315002291	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
657315002292	dimer interface [polypeptide binding]; other site
657315002293	anticodon binding site; other site
657315002294	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
657315002295	homodimer interface [polypeptide binding]; other site
657315002296	motif 1; other site
657315002297	active site
657315002298	motif 2; other site
657315002299	GAD domain; Region: GAD; pfam02938
657315002300	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
657315002301	active site
657315002302	motif 3; other site
657315002303	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
657315002304	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
657315002305	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
657315002306	Cupin domain; Region: Cupin_2; cl17218
657315002307	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657315002308	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315002309	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
657315002310	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
657315002311	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
657315002312	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315002313	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657315002314	DNA binding site [nucleotide binding]
657315002315	domain linker motif; other site
657315002316	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657315002317	dimerization interface [polypeptide binding]; other site
657315002318	ligand binding site [chemical binding]; other site
657315002319	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
657315002320	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315002321	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
657315002322	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
657315002323	Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364
657315002324	Glycosyl hydrolase family 43; Region: GH43_4; cd08983
657315002325	active site
657315002326	beta-D-glucuronidase; Provisional; Region: PRK10150
657315002327	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
657315002328	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
657315002329	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
657315002330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
657315002331	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
657315002332	alpha-galactosidase; Region: PLN02808; cl17638
657315002333	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315002334	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315002335	active site
657315002336	phosphorylation site [posttranslational modification]
657315002337	intermolecular recognition site; other site
657315002338	dimerization interface [polypeptide binding]; other site
657315002339	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315002340	DNA binding site [nucleotide binding]
657315002341	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
657315002342	dimerization interface [polypeptide binding]; other site
657315002343	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315002344	dimer interface [polypeptide binding]; other site
657315002345	phosphorylation site [posttranslational modification]
657315002346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315002347	ATP binding site [chemical binding]; other site
657315002348	Mg2+ binding site [ion binding]; other site
657315002349	G-X-G motif; other site
657315002350	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
657315002351	Response regulator receiver domain; Region: Response_reg; pfam00072
657315002352	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315002353	active site
657315002354	phosphorylation site [posttranslational modification]
657315002355	intermolecular recognition site; other site
657315002356	dimerization interface [polypeptide binding]; other site
657315002357	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
657315002358	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
657315002359	putative active site [active]
657315002360	oxyanion strand; other site
657315002361	catalytic triad [active]
657315002362	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
657315002363	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
657315002364	substrate binding site [chemical binding]; other site
657315002365	glutamase interaction surface [polypeptide binding]; other site
657315002366	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
657315002367	ligand binding site [chemical binding]; other site
657315002368	active site
657315002369	UGI interface [polypeptide binding]; other site
657315002370	catalytic site [active]
657315002371	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
657315002372	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
657315002373	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
657315002374	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
657315002375	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
657315002376	substrate binding pocket [chemical binding]; other site
657315002377	dimer interface [polypeptide binding]; other site
657315002378	inhibitor binding site; inhibition site
657315002379	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
657315002380	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
657315002381	B12 binding site [chemical binding]; other site
657315002382	cobalt ligand [ion binding]; other site
657315002383	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
657315002384	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
657315002385	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
657315002386	homotrimer interaction site [polypeptide binding]; other site
657315002387	zinc binding site [ion binding]; other site
657315002388	CDP-binding sites; other site
657315002389	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657315002390	Interdomain contacts; other site
657315002391	Cytokine receptor motif; other site
657315002392	Response regulator receiver domain; Region: Response_reg; pfam00072
657315002393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315002394	active site
657315002395	phosphorylation site [posttranslational modification]
657315002396	intermolecular recognition site; other site
657315002397	dimerization interface [polypeptide binding]; other site
657315002398	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315002399	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315002400	metal binding site [ion binding]; metal-binding site
657315002401	active site
657315002402	I-site; other site
657315002403	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
657315002404	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
657315002405	active site
657315002406	HIGH motif; other site
657315002407	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657315002408	active site
657315002409	KMSKS motif; other site
657315002410	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
657315002411	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
657315002412	active site
657315002413	metal binding site [ion binding]; metal-binding site
657315002414	dimerization interface [polypeptide binding]; other site
657315002415	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
657315002416	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
657315002417	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
657315002418	RNA polymerase factor sigma-70; Validated; Region: PRK08295
657315002419	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657315002420	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
657315002421	DNA binding residues [nucleotide binding]
657315002422	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
657315002423	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
657315002424	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
657315002425	PA14 domain; Region: PA14; cl08459
657315002426	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
657315002427	active site
657315002428	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
657315002429	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
657315002430	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
657315002431	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
657315002432	active site
657315002433	DNA polymerase I; Provisional; Region: PRK05755
657315002434	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
657315002435	active site
657315002436	metal binding site 1 [ion binding]; metal-binding site
657315002437	putative 5' ssDNA interaction site; other site
657315002438	metal binding site 3; metal-binding site
657315002439	metal binding site 2 [ion binding]; metal-binding site
657315002440	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
657315002441	putative DNA binding site [nucleotide binding]; other site
657315002442	putative metal binding site [ion binding]; other site
657315002443	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
657315002444	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
657315002445	active site
657315002446	DNA binding site [nucleotide binding]
657315002447	catalytic site [active]
657315002448	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
657315002449	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
657315002450	CoA-binding site [chemical binding]; other site
657315002451	ATP-binding [chemical binding]; other site
657315002452	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
657315002453	Cell division protein FtsA; Region: FtsA; smart00842
657315002454	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
657315002455	nucleotide binding site [chemical binding]; other site
657315002456	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
657315002457	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
657315002458	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
657315002459	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
657315002460	IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330
657315002461	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
657315002462	AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138
657315002463	hypothetical protein; Provisional; Region: PRK13670
657315002464	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
657315002465	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
657315002466	propionate/acetate kinase; Provisional; Region: PRK12379
657315002467	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
657315002468	Protein of unknown function, DUF624; Region: DUF624; pfam04854
657315002469	putative phosphate acyltransferase; Provisional; Region: PRK05331
657315002470	acyl carrier protein; Provisional; Region: acpP; PRK00982
657315002471	ribonuclease III; Reviewed; Region: rnc; PRK00102
657315002472	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
657315002473	dimerization interface [polypeptide binding]; other site
657315002474	active site
657315002475	metal binding site [ion binding]; metal-binding site
657315002476	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
657315002477	dsRNA binding site [nucleotide binding]; other site
657315002478	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
657315002479	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
657315002480	Walker A/P-loop; other site
657315002481	ATP binding site [chemical binding]; other site
657315002482	Q-loop/lid; other site
657315002483	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
657315002484	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
657315002485	ABC transporter signature motif; other site
657315002486	Walker B; other site
657315002487	D-loop; other site
657315002488	H-loop/switch region; other site
657315002489	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
657315002490	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
657315002491	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657315002492	threonine dehydratase; Provisional; Region: PRK08198
657315002493	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
657315002494	tetramer interface [polypeptide binding]; other site
657315002495	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315002496	catalytic residue [active]
657315002497	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
657315002498	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
657315002499	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
657315002500	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
657315002501	GTP binding site [chemical binding]; other site
657315002502	Signal peptide binding domain; Region: SRP_SPB; pfam02978
657315002503	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
657315002504	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
657315002505	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
657315002506	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
657315002507	RimM N-terminal domain; Region: RimM; pfam01782
657315002508	PRC-barrel domain; Region: PRC; pfam05239
657315002509	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
657315002510	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
657315002511	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
657315002512	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
657315002513	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
657315002514	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657315002515	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315002516	homodimer interface [polypeptide binding]; other site
657315002517	catalytic residue [active]
657315002518	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315002519	Zn2+ binding site [ion binding]; other site
657315002520	Mg2+ binding site [ion binding]; other site
657315002521	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
657315002522	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
657315002523	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
657315002524	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
657315002525	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
657315002526	S-ribosylhomocysteinase; Provisional; Region: PRK02260
657315002527	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
657315002528	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
657315002529	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
657315002530	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
657315002531	membrane-bound complex binding site; other site
657315002532	hinge residues; other site
657315002533	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
657315002534	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
657315002535	substrate binding pocket [chemical binding]; other site
657315002536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315002537	dimer interface [polypeptide binding]; other site
657315002538	conserved gate region; other site
657315002539	ABC-ATPase subunit interface; other site
657315002540	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
657315002541	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
657315002542	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
657315002543	Walker A/P-loop; other site
657315002544	ATP binding site [chemical binding]; other site
657315002545	Q-loop/lid; other site
657315002546	ABC transporter signature motif; other site
657315002547	Walker B; other site
657315002548	D-loop; other site
657315002549	H-loop/switch region; other site
657315002550	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
657315002551	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315002552	S-adenosylmethionine binding site [chemical binding]; other site
657315002553	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
657315002554	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
657315002555	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657315002556	catalytic residue [active]
657315002557	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
657315002558	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
657315002559	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
657315002560	Ligand Binding Site [chemical binding]; other site
657315002561	PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381
657315002562	regulatory protein interface [polypeptide binding]; other site
657315002563	regulatory phosphorylation site [posttranslational modification]; other site
657315002564	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
657315002565	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
657315002566	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315002567	FeS/SAM binding site; other site
657315002568	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
657315002569	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
657315002570	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
657315002571	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
657315002572	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
657315002573	Protein of unknown function (DUF964); Region: DUF964; pfam06133
657315002574	YceG-like family; Region: YceG; pfam02618
657315002575	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
657315002576	Peptidase family U32; Region: Peptidase_U32; pfam01136
657315002577	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
657315002578	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
657315002579	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
657315002580	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
657315002581	putative ligand binding site [chemical binding]; other site
657315002582	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
657315002583	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
657315002584	TM-ABC transporter signature motif; other site
657315002585	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
657315002586	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
657315002587	TM-ABC transporter signature motif; other site
657315002588	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657315002589	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657315002590	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657315002591	dimerization interface [polypeptide binding]; other site
657315002592	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
657315002593	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
657315002594	GDP-binding site [chemical binding]; other site
657315002595	ACT binding site; other site
657315002596	IMP binding site; other site
657315002597	Uncharacterized conserved protein [Function unknown]; Region: COG2966
657315002598	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
657315002599	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
657315002600	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
657315002601	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
657315002602	active site
657315002603	HIGH motif; other site
657315002604	dimer interface [polypeptide binding]; other site
657315002605	KMSKS motif; other site
657315002606	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
657315002607	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
657315002608	GTP/Mg2+ binding site [chemical binding]; other site
657315002609	G4 box; other site
657315002610	G5 box; other site
657315002611	G1 box; other site
657315002612	Switch I region; other site
657315002613	G2 box; other site
657315002614	G3 box; other site
657315002615	Switch II region; other site
657315002616	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
657315002617	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
657315002618	Catalytic site [active]
657315002619	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
657315002620	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
657315002621	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
657315002622	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
657315002623	Walker A/P-loop; other site
657315002624	ATP binding site [chemical binding]; other site
657315002625	Q-loop/lid; other site
657315002626	ABC transporter signature motif; other site
657315002627	Walker B; other site
657315002628	D-loop; other site
657315002629	H-loop/switch region; other site
657315002630	GTP-binding protein Der; Reviewed; Region: PRK00093
657315002631	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
657315002632	G1 box; other site
657315002633	GTP/Mg2+ binding site [chemical binding]; other site
657315002634	Switch I region; other site
657315002635	G2 box; other site
657315002636	Switch II region; other site
657315002637	G3 box; other site
657315002638	G4 box; other site
657315002639	G5 box; other site
657315002640	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
657315002641	G1 box; other site
657315002642	GTP/Mg2+ binding site [chemical binding]; other site
657315002643	Switch I region; other site
657315002644	G2 box; other site
657315002645	G3 box; other site
657315002646	Switch II region; other site
657315002647	G4 box; other site
657315002648	G5 box; other site
657315002649	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
657315002650	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
657315002651	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
657315002652	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
657315002653	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
657315002654	trimer interface [polypeptide binding]; other site
657315002655	active site
657315002656	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
657315002657	classical (c) SDRs; Region: SDR_c; cd05233
657315002658	NAD(P) binding site [chemical binding]; other site
657315002659	active site
657315002660	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
657315002661	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
657315002662	Walker A/P-loop; other site
657315002663	ATP binding site [chemical binding]; other site
657315002664	Q-loop/lid; other site
657315002665	ABC transporter signature motif; other site
657315002666	Walker B; other site
657315002667	D-loop; other site
657315002668	H-loop/switch region; other site
657315002669	TOBE domain; Region: TOBE; pfam03459
657315002670	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
657315002671	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315002672	ATP binding site [chemical binding]; other site
657315002673	Mg2+ binding site [ion binding]; other site
657315002674	G-X-G motif; other site
657315002675	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
657315002676	anchoring element; other site
657315002677	dimer interface [polypeptide binding]; other site
657315002678	ATP binding site [chemical binding]; other site
657315002679	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
657315002680	active site
657315002681	putative metal-binding site [ion binding]; other site
657315002682	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
657315002683	DNA gyrase subunit A; Validated; Region: PRK05560
657315002684	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
657315002685	CAP-like domain; other site
657315002686	active site
657315002687	primary dimer interface [polypeptide binding]; other site
657315002688	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657315002689	CAAX protease self-immunity; Region: Abi; pfam02517
657315002690	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
657315002691	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657315002692	Coenzyme A binding pocket [chemical binding]; other site
657315002693	Cna protein B-type domain; Region: Cna_B; pfam05738
657315002694	Cna protein B-type domain; Region: Cna_B; pfam05738
657315002695	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
657315002696	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
657315002697	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
657315002698	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
657315002699	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315002700	non-specific DNA binding site [nucleotide binding]; other site
657315002701	salt bridge; other site
657315002702	sequence-specific DNA binding site [nucleotide binding]; other site
657315002703	Replication initiation factor; Region: Rep_trans; pfam02486
657315002704	Protein of unknown function (DUF3789); Region: DUF3789; pfam12664
657315002705	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
657315002706	Antirestriction protein (ArdA); Region: ArdA; cl01953
657315002707	Antirestriction protein (ArdA); Region: ArdA; pfam07275
657315002708	AAA-like domain; Region: AAA_10; pfam12846
657315002709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657315002710	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
657315002711	N-acetyl-D-glucosamine binding site [chemical binding]; other site
657315002712	catalytic residue [active]
657315002713	NlpC/P60 family; Region: NLPC_P60; pfam00877
657315002714	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
657315002715	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315002716	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315002717	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
657315002718	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657315002719	Coenzyme A binding pocket [chemical binding]; other site
657315002720	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315002721	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
657315002722	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315002723	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315002724	dimer interface [polypeptide binding]; other site
657315002725	phosphorylation site [posttranslational modification]
657315002726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315002727	ATP binding site [chemical binding]; other site
657315002728	Mg2+ binding site [ion binding]; other site
657315002729	G-X-G motif; other site
657315002730	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315002731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315002732	active site
657315002733	phosphorylation site [posttranslational modification]
657315002734	intermolecular recognition site; other site
657315002735	dimerization interface [polypeptide binding]; other site
657315002736	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315002737	DNA binding site [nucleotide binding]
657315002738	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
657315002739	FtsX-like permease family; Region: FtsX; pfam02687
657315002740	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657315002741	FtsX-like permease family; Region: FtsX; pfam02687
657315002742	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657315002743	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657315002744	Walker A/P-loop; other site
657315002745	ATP binding site [chemical binding]; other site
657315002746	Q-loop/lid; other site
657315002747	ABC transporter signature motif; other site
657315002748	Walker B; other site
657315002749	D-loop; other site
657315002750	H-loop/switch region; other site
657315002751	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
657315002752	Helix-turn-helix domain; Region: HTH_16; pfam12645
657315002753	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
657315002754	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
657315002755	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315002756	active site
657315002757	DNA binding site [nucleotide binding]
657315002758	Int/Topo IB signature motif; other site
657315002759	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
657315002760	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
657315002761	active site
657315002762	dimer interface [polypeptide binding]; other site
657315002763	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
657315002764	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
657315002765	active site
657315002766	FMN binding site [chemical binding]; other site
657315002767	substrate binding site [chemical binding]; other site
657315002768	3Fe-4S cluster binding site [ion binding]; other site
657315002769	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
657315002770	domain interface; other site
657315002771	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
657315002772	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
657315002773	Response regulator receiver domain; Region: Response_reg; pfam00072
657315002774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315002775	active site
657315002776	phosphorylation site [posttranslational modification]
657315002777	intermolecular recognition site; other site
657315002778	dimerization interface [polypeptide binding]; other site
657315002779	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657315002780	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315002781	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315002782	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315002783	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315002784	dimerization interface [polypeptide binding]; other site
657315002785	Histidine kinase; Region: His_kinase; pfam06580
657315002786	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315002787	ATP binding site [chemical binding]; other site
657315002788	Mg2+ binding site [ion binding]; other site
657315002789	G-X-G motif; other site
657315002790	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657315002791	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
657315002792	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
657315002793	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
657315002794	Walker A/P-loop; other site
657315002795	ATP binding site [chemical binding]; other site
657315002796	Q-loop/lid; other site
657315002797	ABC transporter signature motif; other site
657315002798	Walker B; other site
657315002799	D-loop; other site
657315002800	H-loop/switch region; other site
657315002801	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
657315002802	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
657315002803	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
657315002804	TM-ABC transporter signature motif; other site
657315002805	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
657315002806	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
657315002807	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
657315002808	TM-ABC transporter signature motif; other site
657315002809	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
657315002810	putative ligand binding site [chemical binding]; other site
657315002811	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
657315002812	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
657315002813	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
657315002814	active site
657315002815	Zn binding site [ion binding]; other site
657315002816	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
657315002817	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
657315002818	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
657315002819	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315002820	FeS/SAM binding site; other site
657315002821	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
657315002822	Malic enzyme, N-terminal domain; Region: malic; pfam00390
657315002823	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
657315002824	putative NAD(P) binding site [chemical binding]; other site
657315002825	Putative catalytic domain of type II restriction enzyme NgoFVII and similar proteins; Region: PLDc_RE_NgoFVII; cd09177
657315002826	PLD-like domain; Region: PLDc_2; pfam13091
657315002827	putative homodimer interface [polypeptide binding]; other site
657315002828	putative active site [active]
657315002829	catalytic site [active]
657315002830	Z1 domain; Region: Z1; pfam10593
657315002831	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
657315002832	Winged helix-turn helix; Region: HTH_29; pfam13551
657315002833	Helix-turn-helix domain; Region: HTH_28; pfam13518
657315002834	DDE superfamily endonuclease; Region: DDE_3; pfam13358
657315002835	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
657315002836	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
657315002837	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
657315002838	cofactor binding site; other site
657315002839	DNA binding site [nucleotide binding]
657315002840	substrate interaction site [chemical binding]; other site
657315002841	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
657315002842	additional DNA contacts [nucleotide binding]; other site
657315002843	mismatch recognition site; other site
657315002844	active site
657315002845	zinc binding site [ion binding]; other site
657315002846	DNA intercalation site [nucleotide binding]; other site
657315002847	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
657315002848	Methyltransferase domain; Region: Methyltransf_23; pfam13489
657315002849	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315002850	S-adenosylmethionine binding site [chemical binding]; other site
657315002851	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205
657315002852	PLD-like domain; Region: PLDc_2; pfam13091
657315002853	putative homodimer interface [polypeptide binding]; other site
657315002854	putative active site [active]
657315002855	catalytic site [active]
657315002856	DEAD-like helicases superfamily; Region: DEXDc; smart00487
657315002857	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
657315002858	ATP binding site [chemical binding]; other site
657315002859	putative Mg++ binding site [ion binding]; other site
657315002860	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
657315002861	nucleotide binding region [chemical binding]; other site
657315002862	ATP-binding site [chemical binding]; other site
657315002863	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
657315002864	FMN binding site [chemical binding]; other site
657315002865	dimer interface [polypeptide binding]; other site
657315002866	Transglutaminase/protease-like homologues; Region: TGc; smart00460
657315002867	Predicted transcriptional regulator [Transcription]; Region: COG2378
657315002868	WYL domain; Region: WYL; pfam13280
657315002869	RelB antitoxin; Region: RelB; cl01171
657315002870	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
657315002871	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
657315002872	Beta-lactamase; Region: Beta-lactamase; pfam00144
657315002873	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315002874	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657315002875	catalytic residues [active]
657315002876	catalytic nucleophile [active]
657315002877	Recombinase; Region: Recombinase; pfam07508
657315002878	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315002879	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
657315002880	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657315002881	DNA binding residues [nucleotide binding]
657315002882	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
657315002883	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
657315002884	putative active site [active]
657315002885	putative metal binding site [ion binding]; other site
657315002886	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657315002887	FtsX-like permease family; Region: FtsX; pfam02687
657315002888	FtsX-like permease family; Region: FtsX; pfam02687
657315002889	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657315002890	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657315002891	Walker A/P-loop; other site
657315002892	ATP binding site [chemical binding]; other site
657315002893	Q-loop/lid; other site
657315002894	ABC transporter signature motif; other site
657315002895	Walker B; other site
657315002896	D-loop; other site
657315002897	H-loop/switch region; other site
657315002898	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315002899	Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705
657315002900	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315002901	dimer interface [polypeptide binding]; other site
657315002902	phosphorylation site [posttranslational modification]
657315002903	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315002904	ATP binding site [chemical binding]; other site
657315002905	Mg2+ binding site [ion binding]; other site
657315002906	G-X-G motif; other site
657315002907	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315002908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315002909	active site
657315002910	phosphorylation site [posttranslational modification]
657315002911	intermolecular recognition site; other site
657315002912	dimerization interface [polypeptide binding]; other site
657315002913	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315002914	DNA binding site [nucleotide binding]
657315002915	Helix-turn-helix domain; Region: HTH_17; pfam12728
657315002916	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315002917	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315002918	non-specific DNA binding site [nucleotide binding]; other site
657315002919	salt bridge; other site
657315002920	sequence-specific DNA binding site [nucleotide binding]; other site
657315002921	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
657315002922	AAA domain; Region: AAA_18; pfam13238
657315002923	active site
657315002924	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
657315002925	Domain of unknown function (DUF4316); Region: DUF4316; pfam14195
657315002926	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
657315002927	Domain of unknown function (DUF4315); Region: DUF4315; pfam14193
657315002928	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
657315002929	NlpC/P60 family; Region: NLPC_P60; pfam00877
657315002930	PrgI family protein; Region: PrgI; pfam12666
657315002931	MT-A70; Region: MT-A70; cl01947
657315002932	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
657315002933	DNA methylase; Region: N6_N4_Mtase; cl17433
657315002934	DNA methylase; Region: N6_N4_Mtase; pfam01555
657315002935	SpoVG; Region: SpoVG; cl00915
657315002936	Maff2 family; Region: Maff2; pfam12750
657315002937	Antirestriction protein (ArdA); Region: ArdA; pfam07275
657315002938	ParB-like nuclease domain; Region: ParBc; pfam02195
657315002939	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
657315002940	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
657315002941	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
657315002942	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
657315002943	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
657315002944	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
657315002945	Part of AAA domain; Region: AAA_19; pfam13245
657315002946	Family description; Region: UvrD_C_2; pfam13538
657315002947	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
657315002948	Maf-like protein; Region: Maf; pfam02545
657315002949	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
657315002950	active site
657315002951	dimer interface [polypeptide binding]; other site
657315002952	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
657315002953	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
657315002954	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
657315002955	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315002956	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657315002957	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
657315002958	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657315002959	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657315002960	ABC transporter; Region: ABC_tran_2; pfam12848
657315002961	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657315002962	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
657315002963	Cupin domain; Region: Cupin_2; cl17218
657315002964	EDD domain protein, DegV family; Region: DegV; TIGR00762
657315002965	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
657315002966	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
657315002967	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657315002968	Walker A motif; other site
657315002969	ATP binding site [chemical binding]; other site
657315002970	Walker B motif; other site
657315002971	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
657315002972	nucleotide binding site [chemical binding]; other site
657315002973	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
657315002974	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
657315002975	nucleotide binding site [chemical binding]; other site
657315002976	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
657315002977	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
657315002978	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
657315002979	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
657315002980	Rhomboid family; Region: Rhomboid; cl11446
657315002981	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
657315002982	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
657315002983	putative NADH binding site [chemical binding]; other site
657315002984	putative active site [active]
657315002985	nudix motif; other site
657315002986	putative metal binding site [ion binding]; other site
657315002987	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
657315002988	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
657315002989	HlyD family secretion protein; Region: HlyD_3; pfam13437
657315002990	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657315002991	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
657315002992	FtsX-like permease family; Region: FtsX; pfam02687
657315002993	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
657315002994	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
657315002995	NodB motif; other site
657315002996	active site
657315002997	catalytic site [active]
657315002998	Cd binding site [ion binding]; other site
657315002999	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
657315003000	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
657315003001	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
657315003002	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
657315003003	active site
657315003004	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
657315003005	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
657315003006	active site
657315003007	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
657315003008	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
657315003009	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
657315003010	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323
657315003011	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
657315003012	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
657315003013	Tetramer interface [polypeptide binding]; other site
657315003014	active site
657315003015	FMN-binding site [chemical binding]; other site
657315003016	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
657315003017	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
657315003018	hinge; other site
657315003019	active site
657315003020	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
657315003021	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
657315003022	Preprotein translocase subunit; Region: YajC; pfam02699
657315003023	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315003024	non-specific DNA binding site [nucleotide binding]; other site
657315003025	salt bridge; other site
657315003026	sequence-specific DNA binding site [nucleotide binding]; other site
657315003027	Radical SAM superfamily; Region: Radical_SAM; pfam04055
657315003028	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315003029	FeS/SAM binding site; other site
657315003030	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
657315003031	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315003032	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315003033	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315003034	Walker A/P-loop; other site
657315003035	ATP binding site [chemical binding]; other site
657315003036	Q-loop/lid; other site
657315003037	ABC transporter signature motif; other site
657315003038	Walker B; other site
657315003039	D-loop; other site
657315003040	H-loop/switch region; other site
657315003041	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
657315003042	tartrate dehydrogenase; Region: TTC; TIGR02089
657315003043	Dehydratase family; Region: ILVD_EDD; cl00340
657315003044	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
657315003045	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
657315003046	PYR/PP interface [polypeptide binding]; other site
657315003047	dimer interface [polypeptide binding]; other site
657315003048	TPP binding site [chemical binding]; other site
657315003049	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
657315003050	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
657315003051	TPP-binding site [chemical binding]; other site
657315003052	dimer interface [polypeptide binding]; other site
657315003053	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
657315003054	homodimer interface [polypeptide binding]; other site
657315003055	substrate-cofactor binding pocket; other site
657315003056	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315003057	catalytic residue [active]
657315003058	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
657315003059	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
657315003060	putative ligand binding site [chemical binding]; other site
657315003061	putative NAD binding site [chemical binding]; other site
657315003062	putative catalytic site [active]
657315003063	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
657315003064	L-serine binding site [chemical binding]; other site
657315003065	ACT domain interface; other site
657315003066	Uncharacterized conserved protein [Function unknown]; Region: COG4198
657315003067	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
657315003068	mechanosensitive channel MscS; Provisional; Region: PRK10334
657315003069	Mechanosensitive ion channel; Region: MS_channel; pfam00924
657315003070	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
657315003071	DNA-binding site [nucleotide binding]; DNA binding site
657315003072	RNA-binding motif; other site
657315003073	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
657315003074	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
657315003075	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
657315003076	Peptidase M16C associated; Region: M16C_assoc; pfam08367
657315003077	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
657315003078	GTPase Era; Reviewed; Region: era; PRK00089
657315003079	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
657315003080	G1 box; other site
657315003081	GTP/Mg2+ binding site [chemical binding]; other site
657315003082	Switch I region; other site
657315003083	G2 box; other site
657315003084	Switch II region; other site
657315003085	G3 box; other site
657315003086	G4 box; other site
657315003087	G5 box; other site
657315003088	KH domain; Region: KH_2; pfam07650
657315003089	Recombination protein O N terminal; Region: RecO_N; pfam11967
657315003090	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
657315003091	Recombination protein O C terminal; Region: RecO_C; pfam02565
657315003092	glycyl-tRNA synthetase; Provisional; Region: PRK04173
657315003093	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
657315003094	motif 1; other site
657315003095	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
657315003096	active site
657315003097	motif 2; other site
657315003098	motif 3; other site
657315003099	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
657315003100	anticodon binding site; other site
657315003101	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
657315003102	Acyltransferase family; Region: Acyl_transf_3; pfam01757
657315003103	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
657315003104	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
657315003105	HTH domain; Region: HTH_11; cl17392
657315003106	GrpE; Region: GrpE; pfam01025
657315003107	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
657315003108	dimer interface [polypeptide binding]; other site
657315003109	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
657315003110	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
657315003111	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
657315003112	nucleotide binding site [chemical binding]; other site
657315003113	NEF interaction site [polypeptide binding]; other site
657315003114	SBD interface [polypeptide binding]; other site
657315003115	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
657315003116	chaperone protein DnaJ; Provisional; Region: PRK10767
657315003117	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
657315003118	HSP70 interaction site [polypeptide binding]; other site
657315003119	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
657315003120	substrate binding site [polypeptide binding]; other site
657315003121	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
657315003122	Zn binding sites [ion binding]; other site
657315003123	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
657315003124	dimer interface [polypeptide binding]; other site
657315003125	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
657315003126	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
657315003127	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
657315003128	metal binding site 2 [ion binding]; metal-binding site
657315003129	putative DNA binding helix; other site
657315003130	metal binding site 1 [ion binding]; metal-binding site
657315003131	dimer interface [polypeptide binding]; other site
657315003132	structural Zn2+ binding site [ion binding]; other site
657315003133	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
657315003134	Peptidase family M23; Region: Peptidase_M23; pfam01551
657315003135	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657315003136	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315003137	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315003138	metal binding site [ion binding]; metal-binding site
657315003139	active site
657315003140	I-site; other site
657315003141	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
657315003142	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
657315003143	G1 box; other site
657315003144	putative GEF interaction site [polypeptide binding]; other site
657315003145	GTP/Mg2+ binding site [chemical binding]; other site
657315003146	Switch I region; other site
657315003147	G2 box; other site
657315003148	G3 box; other site
657315003149	Switch II region; other site
657315003150	G4 box; other site
657315003151	G5 box; other site
657315003152	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
657315003153	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
657315003154	single-stranded DNA-binding protein; Provisional; Region: PRK05813
657315003155	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
657315003156	dimer interface [polypeptide binding]; other site
657315003157	ssDNA binding site [nucleotide binding]; other site
657315003158	tetramer (dimer of dimers) interface [polypeptide binding]; other site
657315003159	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
657315003160	dihydrodipicolinate synthase; Region: dapA; TIGR00674
657315003161	dimer interface [polypeptide binding]; other site
657315003162	active site
657315003163	catalytic residue [active]
657315003164	dihydrodipicolinate reductase; Provisional; Region: PRK00048
657315003165	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
657315003166	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
657315003167	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
657315003168	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
657315003169	endonuclease IV; Provisional; Region: PRK01060
657315003170	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
657315003171	AP (apurinic/apyrimidinic) site pocket; other site
657315003172	DNA interaction; other site
657315003173	Metal-binding active site; metal-binding site
657315003174	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
657315003175	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
657315003176	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657315003177	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
657315003178	spermidine synthase; Provisional; Region: PRK00811
657315003179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315003180	S-adenosylmethionine binding site [chemical binding]; other site
657315003181	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
657315003182	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
657315003183	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
657315003184	dimer interface [polypeptide binding]; other site
657315003185	active site
657315003186	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
657315003187	catalytic residues [active]
657315003188	substrate binding site [chemical binding]; other site
657315003189	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
657315003190	agmatine deiminase; Region: agmatine_aguA; TIGR03380
657315003191	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
657315003192	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
657315003193	putative active site; other site
657315003194	catalytic triad [active]
657315003195	putative dimer interface [polypeptide binding]; other site
657315003196	asparagine synthetase AsnA; Provisional; Region: PRK05425
657315003197	motif 1; other site
657315003198	dimer interface [polypeptide binding]; other site
657315003199	active site
657315003200	motif 2; other site
657315003201	motif 3; other site
657315003202	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
657315003203	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315003204	dimerization interface [polypeptide binding]; other site
657315003205	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315003206	dimer interface [polypeptide binding]; other site
657315003207	putative CheW interface [polypeptide binding]; other site
657315003208	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657315003209	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657315003210	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
657315003211	putative active site [active]
657315003212	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
657315003213	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657315003214	Walker A/P-loop; other site
657315003215	ATP binding site [chemical binding]; other site
657315003216	ABC transporter; Region: ABC_tran; pfam00005
657315003217	Q-loop/lid; other site
657315003218	ABC transporter signature motif; other site
657315003219	Walker B; other site
657315003220	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315003221	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
657315003222	catalytic residues [active]
657315003223	catalytic nucleophile [active]
657315003224	Recombinase; Region: Recombinase; pfam07508
657315003225	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315003226	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315003227	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315003228	non-specific DNA binding site [nucleotide binding]; other site
657315003229	salt bridge; other site
657315003230	sequence-specific DNA binding site [nucleotide binding]; other site
657315003231	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
657315003232	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
657315003233	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
657315003234	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
657315003235	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
657315003236	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
657315003237	RPB1 interaction site [polypeptide binding]; other site
657315003238	RPB10 interaction site [polypeptide binding]; other site
657315003239	RPB11 interaction site [polypeptide binding]; other site
657315003240	RPB3 interaction site [polypeptide binding]; other site
657315003241	RPB12 interaction site [polypeptide binding]; other site
657315003242	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
657315003243	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
657315003244	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
657315003245	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
657315003246	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
657315003247	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
657315003248	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
657315003249	G-loop; other site
657315003250	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
657315003251	DNA binding site [nucleotide binding]
657315003252	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
657315003253	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
657315003254	S17 interaction site [polypeptide binding]; other site
657315003255	S8 interaction site; other site
657315003256	16S rRNA interaction site [nucleotide binding]; other site
657315003257	streptomycin interaction site [chemical binding]; other site
657315003258	23S rRNA interaction site [nucleotide binding]; other site
657315003259	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
657315003260	elongation factor Tu; Reviewed; Region: PRK00049
657315003261	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
657315003262	G1 box; other site
657315003263	GEF interaction site [polypeptide binding]; other site
657315003264	GTP/Mg2+ binding site [chemical binding]; other site
657315003265	Switch I region; other site
657315003266	G2 box; other site
657315003267	G3 box; other site
657315003268	Switch II region; other site
657315003269	G4 box; other site
657315003270	G5 box; other site
657315003271	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
657315003272	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
657315003273	Antibiotic Binding Site [chemical binding]; other site
657315003274	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
657315003275	EamA-like transporter family; Region: EamA; pfam00892
657315003276	EamA-like transporter family; Region: EamA; pfam00892
657315003277	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
657315003278	CAAX protease self-immunity; Region: Abi; pfam02517
657315003279	putative pectinesterase; Region: PLN02432; cl01911
657315003280	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
657315003281	intersubunit interface [polypeptide binding]; other site
657315003282	active site
657315003283	Zn2+ binding site [ion binding]; other site
657315003284	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
657315003285	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234
657315003286	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
657315003287	active site
657315003288	catalytic site [active]
657315003289	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
657315003290	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
657315003291	NAD(P) binding site [chemical binding]; other site
657315003292	active site
657315003293	Cache domain; Region: Cache_1; pfam02743
657315003294	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315003295	dimerization interface [polypeptide binding]; other site
657315003296	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315003297	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315003298	dimer interface [polypeptide binding]; other site
657315003299	putative CheW interface [polypeptide binding]; other site
657315003300	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
657315003301	active site
657315003302	dimer interface [polypeptide binding]; other site
657315003303	TraX protein; Region: TraX; pfam05857
657315003304	conjugal transfer protein TrbP; Provisional; Region: PRK13882
657315003305	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
657315003306	substrate binding site [chemical binding]; other site
657315003307	multimerization interface [polypeptide binding]; other site
657315003308	ATP binding site [chemical binding]; other site
657315003309	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
657315003310	thiamine phosphate binding site [chemical binding]; other site
657315003311	active site
657315003312	pyrophosphate binding site [ion binding]; other site
657315003313	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
657315003314	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315003315	motif II; other site
657315003316	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
657315003317	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657315003318	Coenzyme A binding pocket [chemical binding]; other site
657315003319	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
657315003320	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
657315003321	Cl binding site [ion binding]; other site
657315003322	oligomer interface [polypeptide binding]; other site
657315003323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315003324	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
657315003325	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
657315003326	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
657315003327	TrkA-N domain; Region: TrkA_N; pfam02254
657315003328	TrkA-C domain; Region: TrkA_C; pfam02080
657315003329	TrkA-N domain; Region: TrkA_N; pfam02254
657315003330	TrkA-C domain; Region: TrkA_C; pfam02080
657315003331	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
657315003332	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
657315003333	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
657315003334	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
657315003335	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
657315003336	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
657315003337	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
657315003338	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
657315003339	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
657315003340	protein-rRNA interface [nucleotide binding]; other site
657315003341	putative translocon binding site; other site
657315003342	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
657315003343	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
657315003344	G-X-X-G motif; other site
657315003345	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
657315003346	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
657315003347	23S rRNA interface [nucleotide binding]; other site
657315003348	5S rRNA interface [nucleotide binding]; other site
657315003349	putative antibiotic binding site [chemical binding]; other site
657315003350	L25 interface [polypeptide binding]; other site
657315003351	L27 interface [polypeptide binding]; other site
657315003352	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
657315003353	putative translocon interaction site; other site
657315003354	23S rRNA interface [nucleotide binding]; other site
657315003355	signal recognition particle (SRP54) interaction site; other site
657315003356	L23 interface [polypeptide binding]; other site
657315003357	trigger factor interaction site; other site
657315003358	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
657315003359	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
657315003360	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
657315003361	RNA binding site [nucleotide binding]; other site
657315003362	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
657315003363	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
657315003364	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
657315003365	5S rRNA interface [nucleotide binding]; other site
657315003366	L27 interface [polypeptide binding]; other site
657315003367	23S rRNA interface [nucleotide binding]; other site
657315003368	L5 interface [polypeptide binding]; other site
657315003369	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
657315003370	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
657315003371	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
657315003372	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30_like; cd00355
657315003373	23S rRNA binding site - archaea [nucleotide binding]; other site
657315003374	23S rRNA binding site - prokaryotes [nucleotide binding]; other site
657315003375	5S rRNA binding site - archaea; other site
657315003376	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
657315003377	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
657315003378	SecY translocase; Region: SecY; pfam00344
657315003379	adenylate kinase; Reviewed; Region: adk; PRK00279
657315003380	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
657315003381	AMP-binding site [chemical binding]; other site
657315003382	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
657315003383	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
657315003384	active site
657315003385	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
657315003386	RNA binding site [nucleotide binding]; other site
657315003387	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
657315003388	rRNA binding site [nucleotide binding]; other site
657315003389	predicted 30S ribosome binding site; other site
657315003390	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
657315003391	30S ribosomal protein S13; Region: bact_S13; TIGR03631
657315003392	30S ribosomal protein S11; Validated; Region: PRK05309
657315003393	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
657315003394	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
657315003395	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
657315003396	RNA binding surface [nucleotide binding]; other site
657315003397	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
657315003398	Protein of unknown function (DUF1706); Region: DUF1706; cl01748
657315003399	TIGR04076 family protein; Region: TIGR04076
657315003400	TfoX N-terminal domain; Region: TfoX_N; pfam04993
657315003401	Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958
657315003402	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315003403	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315003404	dimerization interface [polypeptide binding]; other site
657315003405	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315003406	dimer interface [polypeptide binding]; other site
657315003407	phosphorylation site [posttranslational modification]
657315003408	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315003409	ATP binding site [chemical binding]; other site
657315003410	Mg2+ binding site [ion binding]; other site
657315003411	G-X-G motif; other site
657315003412	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315003413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315003414	active site
657315003415	phosphorylation site [posttranslational modification]
657315003416	intermolecular recognition site; other site
657315003417	dimerization interface [polypeptide binding]; other site
657315003418	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315003419	DNA binding site [nucleotide binding]
657315003420	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
657315003421	MutS domain III; Region: MutS_III; pfam05192
657315003422	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
657315003423	Walker A/P-loop; other site
657315003424	ATP binding site [chemical binding]; other site
657315003425	Q-loop/lid; other site
657315003426	ABC transporter signature motif; other site
657315003427	Walker B; other site
657315003428	D-loop; other site
657315003429	H-loop/switch region; other site
657315003430	Smr domain; Region: Smr; pfam01713
657315003431	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
657315003432	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
657315003433	generic binding surface II; other site
657315003434	generic binding surface I; other site
657315003435	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315003436	Zn2+ binding site [ion binding]; other site
657315003437	Mg2+ binding site [ion binding]; other site
657315003438	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
657315003439	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
657315003440	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315003441	S-adenosylmethionine binding site [chemical binding]; other site
657315003442	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657315003443	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
657315003444	hypothetical protein; Validated; Region: PRK08116
657315003445	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315003446	Walker A motif; other site
657315003447	ATP binding site [chemical binding]; other site
657315003448	Walker B motif; other site
657315003449	arginine finger; other site
657315003450	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
657315003451	PRTRC system protein D; Region: PRTRC_D; TIGR03739
657315003452	Mg binding site [ion binding]; other site
657315003453	nucleotide binding site [chemical binding]; other site
657315003454	putative protofilament interface [polypeptide binding]; other site
657315003455	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315003456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315003457	active site
657315003458	phosphorylation site [posttranslational modification]
657315003459	intermolecular recognition site; other site
657315003460	dimerization interface [polypeptide binding]; other site
657315003461	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315003462	DNA binding site [nucleotide binding]
657315003463	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315003464	HAMP domain; Region: HAMP; pfam00672
657315003465	dimerization interface [polypeptide binding]; other site
657315003466	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315003467	dimer interface [polypeptide binding]; other site
657315003468	phosphorylation site [posttranslational modification]
657315003469	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315003470	ATP binding site [chemical binding]; other site
657315003471	Mg2+ binding site [ion binding]; other site
657315003472	G-X-G motif; other site
657315003473	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
657315003474	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
657315003475	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315003476	Walker A/P-loop; other site
657315003477	ATP binding site [chemical binding]; other site
657315003478	ABC transporter; Region: ABC_tran; pfam00005
657315003479	Q-loop/lid; other site
657315003480	ABC transporter signature motif; other site
657315003481	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315003482	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
657315003483	Walker A motif; other site
657315003484	ATP binding site [chemical binding]; other site
657315003485	Walker B motif; other site
657315003486	Tetratricopeptide repeat; Region: TPR_12; pfam13424
657315003487	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
657315003488	binding surface
657315003489	TPR motif; other site
657315003490	Tetratricopeptide repeat; Region: TPR_12; pfam13424
657315003491	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315003492	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
657315003493	catalytic residues [active]
657315003494	catalytic nucleophile [active]
657315003495	Recombinase; Region: Recombinase; pfam07508
657315003496	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315003497	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
657315003498	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657315003499	P-loop; other site
657315003500	Magnesium ion binding site [ion binding]; other site
657315003501	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657315003502	Magnesium ion binding site [ion binding]; other site
657315003503	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
657315003504	Cna protein B-type domain; Region: Cna_B; pfam05738
657315003505	Cna protein B-type domain; Region: Cna_B; pfam05738
657315003506	Methyltransferase domain; Region: Methyltransf_26; pfam13659
657315003507	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
657315003508	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
657315003509	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
657315003510	ATP binding site [chemical binding]; other site
657315003511	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
657315003512	nucleotide binding region [chemical binding]; other site
657315003513	helicase superfamily c-terminal domain; Region: HELICc; smart00490
657315003514	ATP-binding site [chemical binding]; other site
657315003515	Ycf1; Region: Ycf1; pfam05758
657315003516	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
657315003517	active site
657315003518	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
657315003519	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
657315003520	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
657315003521	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
657315003522	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
657315003523	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657315003524	Walker A motif; other site
657315003525	ATP binding site [chemical binding]; other site
657315003526	Walker B motif; other site
657315003527	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
657315003528	AAA-like domain; Region: AAA_10; pfam12846
657315003529	Domain of unknown function DUF87; Region: DUF87; pfam01935
657315003530	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
657315003531	active site
657315003532	catalytic site [active]
657315003533	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
657315003534	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
657315003535	N-acetyl-D-glucosamine binding site [chemical binding]; other site
657315003536	catalytic residue [active]
657315003537	CHAP domain; Region: CHAP; cl17642
657315003538	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315003539	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315003540	non-specific DNA binding site [nucleotide binding]; other site
657315003541	salt bridge; other site
657315003542	sequence-specific DNA binding site [nucleotide binding]; other site
657315003543	Helix-turn-helix domain; Region: HTH_17; pfam12728
657315003544	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315003545	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315003546	dimerization interface [polypeptide binding]; other site
657315003547	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315003548	dimer interface [polypeptide binding]; other site
657315003549	phosphorylation site [posttranslational modification]
657315003550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315003551	ATP binding site [chemical binding]; other site
657315003552	Mg2+ binding site [ion binding]; other site
657315003553	G-X-G motif; other site
657315003554	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
657315003555	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
657315003556	DNA binding residues [nucleotide binding]
657315003557	PemK-like protein; Region: PemK; pfam02452
657315003558	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315003559	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
657315003560	catalytic residues [active]
657315003561	catalytic nucleophile [active]
657315003562	Recombinase; Region: Recombinase; pfam07508
657315003563	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315003564	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
657315003565	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
657315003566	Cytochrome c oxidase subunit VIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_VIc; cl02795
657315003567	Subunit VIc/IV interface [polypeptide binding]; other site
657315003568	TfoX N-terminal domain; Region: TfoX_N; cl17592
657315003569	ORF6N domain; Region: ORF6N; pfam10543
657315003570	ORF6N domain; Region: ORF6N; pfam10543
657315003571	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
657315003572	ArsC family; Region: ArsC; pfam03960
657315003573	putative ArsC-like catalytic residues; other site
657315003574	putative TRX-like catalytic residues [active]
657315003575	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
657315003576	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
657315003577	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
657315003578	trimer interface [polypeptide binding]; other site
657315003579	putative metal binding site [ion binding]; other site
657315003580	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
657315003581	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
657315003582	homodimer interface [polypeptide binding]; other site
657315003583	substrate-cofactor binding pocket; other site
657315003584	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315003585	catalytic residue [active]
657315003586	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
657315003587	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
657315003588	Sulfate transporter family; Region: Sulfate_transp; pfam00916
657315003589	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
657315003590	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
657315003591	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
657315003592	Rhomboid family; Region: Rhomboid; pfam01694
657315003593	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
657315003594	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
657315003595	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
657315003596	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
657315003597	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
657315003598	putative metal binding site [ion binding]; other site
657315003599	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
657315003600	Tellurium resistance protein; Region: Tellurium_res; pfam10138
657315003601	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
657315003602	putative metal binding site [ion binding]; other site
657315003603	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
657315003604	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
657315003605	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
657315003606	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
657315003607	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315003608	motif II; other site
657315003609	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
657315003610	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
657315003611	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
657315003612	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
657315003613	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
657315003614	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
657315003615	putative metal binding site [ion binding]; other site
657315003616	hypothetical protein; Validated; Region: PRK00124
657315003617	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
657315003618	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
657315003619	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
657315003620	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
657315003621	enolase; Provisional; Region: eno; PRK00077
657315003622	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
657315003623	dimer interface [polypeptide binding]; other site
657315003624	metal binding site [ion binding]; metal-binding site
657315003625	substrate binding pocket [chemical binding]; other site
657315003626	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
657315003627	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657315003628	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657315003629	Walker A/P-loop; other site
657315003630	ATP binding site [chemical binding]; other site
657315003631	Q-loop/lid; other site
657315003632	ABC transporter signature motif; other site
657315003633	Walker B; other site
657315003634	D-loop; other site
657315003635	H-loop/switch region; other site
657315003636	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657315003637	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
657315003638	PspA/IM30 family; Region: PspA_IM30; pfam04012
657315003639	Fungal protein of unknown function (DUF1742); Region: DUF1742; pfam08432
657315003640	FtsX-like permease family; Region: FtsX; pfam02687
657315003641	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657315003642	FtsX-like permease family; Region: FtsX; pfam02687
657315003643	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
657315003644	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
657315003645	active site
657315003646	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u1; cd12826
657315003647	Cl binding site [ion binding]; other site
657315003648	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
657315003649	oligomer interface [polypeptide binding]; other site
657315003650	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
657315003651	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
657315003652	Walker A/P-loop; other site
657315003653	ATP binding site [chemical binding]; other site
657315003654	Q-loop/lid; other site
657315003655	ABC transporter signature motif; other site
657315003656	Walker B; other site
657315003657	D-loop; other site
657315003658	H-loop/switch region; other site
657315003659	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
657315003660	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315003661	dimer interface [polypeptide binding]; other site
657315003662	conserved gate region; other site
657315003663	putative PBP binding loops; other site
657315003664	ABC-ATPase subunit interface; other site
657315003665	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
657315003666	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
657315003667	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
657315003668	trimer interface [polypeptide binding]; other site
657315003669	active site
657315003670	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
657315003671	catalytic site [active]
657315003672	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
657315003673	dimerization domain swap beta strand [polypeptide binding]; other site
657315003674	regulatory protein interface [polypeptide binding]; other site
657315003675	active site
657315003676	regulatory phosphorylation site [posttranslational modification]; other site
657315003677	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
657315003678	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
657315003679	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657315003680	active site
657315003681	DNA replication protein DnaC; Validated; Region: PRK06835
657315003682	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315003683	Walker A motif; other site
657315003684	ATP binding site [chemical binding]; other site
657315003685	Walker B motif; other site
657315003686	arginine finger; other site
657315003687	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
657315003688	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
657315003689	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
657315003690	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
657315003691	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
657315003692	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
657315003693	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
657315003694	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
657315003695	ligand binding site; other site
657315003696	oligomer interface; other site
657315003697	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
657315003698	dimer interface [polypeptide binding]; other site
657315003699	N-terminal domain interface [polypeptide binding]; other site
657315003700	sulfate 1 binding site; other site
657315003701	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
657315003702	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
657315003703	ligand binding site; other site
657315003704	oligomer interface; other site
657315003705	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
657315003706	dimer interface [polypeptide binding]; other site
657315003707	N-terminal domain interface [polypeptide binding]; other site
657315003708	regulatory protein SpoVG; Reviewed; Region: PRK13259
657315003709	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
657315003710	Substrate binding site; other site
657315003711	Mg++ binding site; other site
657315003712	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
657315003713	putative active site [active]
657315003714	catalytic residue [active]
657315003715	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
657315003716	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
657315003717	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
657315003718	ATP binding site [chemical binding]; other site
657315003719	putative Mg++ binding site [ion binding]; other site
657315003720	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
657315003721	nucleotide binding region [chemical binding]; other site
657315003722	ATP-binding site [chemical binding]; other site
657315003723	TRCF domain; Region: TRCF; pfam03461
657315003724	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
657315003725	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
657315003726	shikimate kinase; Reviewed; Region: aroK; PRK00131
657315003727	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
657315003728	ADP binding site [chemical binding]; other site
657315003729	magnesium binding site [ion binding]; other site
657315003730	putative shikimate binding site; other site
657315003731	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
657315003732	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
657315003733	G5 domain; Region: G5; pfam07501
657315003734	Peptidase family M23; Region: Peptidase_M23; pfam01551
657315003735	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
657315003736	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
657315003737	hinge; other site
657315003738	active site
657315003739	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
657315003740	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
657315003741	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315003742	Zn2+ binding site [ion binding]; other site
657315003743	Mg2+ binding site [ion binding]; other site
657315003744	S-adenosylmethionine synthetase; Validated; Region: PRK05250
657315003745	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
657315003746	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
657315003747	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
657315003748	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315003749	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315003750	dimerization interface [polypeptide binding]; other site
657315003751	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315003752	dimer interface [polypeptide binding]; other site
657315003753	phosphorylation site [posttranslational modification]
657315003754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315003755	ATP binding site [chemical binding]; other site
657315003756	Mg2+ binding site [ion binding]; other site
657315003757	G-X-G motif; other site
657315003758	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315003759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315003760	active site
657315003761	phosphorylation site [posttranslational modification]
657315003762	intermolecular recognition site; other site
657315003763	dimerization interface [polypeptide binding]; other site
657315003764	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315003765	DNA binding site [nucleotide binding]
657315003766	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
657315003767	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
657315003768	active site
657315003769	prolyl-tRNA synthetase; Provisional; Region: PRK08661
657315003770	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
657315003771	dimer interface [polypeptide binding]; other site
657315003772	motif 1; other site
657315003773	active site
657315003774	motif 2; other site
657315003775	motif 3; other site
657315003776	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
657315003777	anticodon binding site; other site
657315003778	zinc-binding site [ion binding]; other site
657315003779	Tetratricopeptide repeat; Region: TPR_12; pfam13424
657315003780	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315003781	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315003782	metal binding site [ion binding]; metal-binding site
657315003783	active site
657315003784	I-site; other site
657315003785	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
657315003786	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
657315003787	active site
657315003788	NTP binding site [chemical binding]; other site
657315003789	metal binding triad [ion binding]; metal-binding site
657315003790	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
657315003791	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315003792	Zn2+ binding site [ion binding]; other site
657315003793	Mg2+ binding site [ion binding]; other site
657315003794	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
657315003795	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
657315003796	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
657315003797	active site
657315003798	ATP binding site [chemical binding]; other site
657315003799	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
657315003800	IHF dimer interface [polypeptide binding]; other site
657315003801	IHF - DNA interface [nucleotide binding]; other site
657315003802	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
657315003803	RNA binding surface [nucleotide binding]; other site
657315003804	YabP family; Region: YabP; cl06766
657315003805	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578
657315003806	Septum formation initiator; Region: DivIC; cl17659
657315003807	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
657315003808	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
657315003809	active site
657315003810	catalytic tetrad [active]
657315003811	stage II sporulation protein E; Region: spore_II_E; TIGR02865
657315003812	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
657315003813	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
657315003814	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
657315003815	Ligand Binding Site [chemical binding]; other site
657315003816	TilS substrate C-terminal domain; Region: TilS_C; smart00977
657315003817	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
657315003818	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
657315003819	membrane-bound complex binding site; other site
657315003820	hinge residues; other site
657315003821	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
657315003822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315003823	dimer interface [polypeptide binding]; other site
657315003824	conserved gate region; other site
657315003825	putative PBP binding loops; other site
657315003826	ABC-ATPase subunit interface; other site
657315003827	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
657315003828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315003829	dimer interface [polypeptide binding]; other site
657315003830	conserved gate region; other site
657315003831	putative PBP binding loops; other site
657315003832	ABC-ATPase subunit interface; other site
657315003833	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
657315003834	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315003835	Walker A/P-loop; other site
657315003836	ATP binding site [chemical binding]; other site
657315003837	Q-loop/lid; other site
657315003838	ABC transporter signature motif; other site
657315003839	Walker B; other site
657315003840	D-loop; other site
657315003841	H-loop/switch region; other site
657315003842	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
657315003843	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
657315003844	Active Sites [active]
657315003845	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
657315003846	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
657315003847	CysD dimerization site [polypeptide binding]; other site
657315003848	G1 box; other site
657315003849	putative GEF interaction site [polypeptide binding]; other site
657315003850	GTP/Mg2+ binding site [chemical binding]; other site
657315003851	Switch I region; other site
657315003852	G2 box; other site
657315003853	G3 box; other site
657315003854	Switch II region; other site
657315003855	G4 box; other site
657315003856	G5 box; other site
657315003857	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
657315003858	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
657315003859	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
657315003860	homodimer interface [polypeptide binding]; other site
657315003861	maltodextrin glucosidase; Provisional; Region: PRK10785
657315003862	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
657315003863	active site
657315003864	homodimer interface [polypeptide binding]; other site
657315003865	catalytic site [active]
657315003866	golgi membrane calcium-translocating P-type ATPase; Region: ATPase-IIA2_Ca; TIGR01522
657315003867	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
657315003868	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
657315003869	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315003870	motif II; other site
657315003871	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
657315003872	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
657315003873	putative deacylase active site [active]
657315003874	Short repeat of unknown function (DUF308); Region: DUF308; pfam03729
657315003875	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315003876	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315003877	metal binding site [ion binding]; metal-binding site
657315003878	active site
657315003879	I-site; other site
657315003880	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
657315003881	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315003882	Zn2+ binding site [ion binding]; other site
657315003883	Mg2+ binding site [ion binding]; other site
657315003884	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
657315003885	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315003886	Zn2+ binding site [ion binding]; other site
657315003887	Mg2+ binding site [ion binding]; other site
657315003888	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
657315003889	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
657315003890	Predicted membrane protein [Function unknown]; Region: COG1511
657315003891	Predicted membrane protein [Function unknown]; Region: COG1971
657315003892	B12 binding domain; Region: B12-binding; pfam02310
657315003893	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
657315003894	B12 binding site [chemical binding]; other site
657315003895	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315003896	FeS/SAM binding site; other site
657315003897	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
657315003898	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
657315003899	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
657315003900	active site
657315003901	catalytic site [active]
657315003902	substrate binding site [chemical binding]; other site
657315003903	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
657315003904	VanW like protein; Region: VanW; pfam04294
657315003905	G5 domain; Region: G5; pfam07501
657315003906	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
657315003907	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
657315003908	dimerization interface [polypeptide binding]; other site
657315003909	putative ATP binding site [chemical binding]; other site
657315003910	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
657315003911	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
657315003912	AsnC family; Region: AsnC_trans_reg; pfam01037
657315003913	hypothetical protein; Validated; Region: PRK07682
657315003914	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657315003915	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315003916	homodimer interface [polypeptide binding]; other site
657315003917	catalytic residue [active]
657315003918	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
657315003919	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
657315003920	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
657315003921	Walker A/P-loop; other site
657315003922	ATP binding site [chemical binding]; other site
657315003923	Q-loop/lid; other site
657315003924	ABC transporter signature motif; other site
657315003925	Walker B; other site
657315003926	D-loop; other site
657315003927	H-loop/switch region; other site
657315003928	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
657315003929	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
657315003930	Walker A/P-loop; other site
657315003931	ATP binding site [chemical binding]; other site
657315003932	Q-loop/lid; other site
657315003933	ABC transporter signature motif; other site
657315003934	Walker B; other site
657315003935	D-loop; other site
657315003936	H-loop/switch region; other site
657315003937	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
657315003938	Helix-turn-helix domain; Region: HTH_31; pfam13560
657315003939	non-specific DNA binding site [nucleotide binding]; other site
657315003940	salt bridge; other site
657315003941	sequence-specific DNA binding site [nucleotide binding]; other site
657315003942	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
657315003943	Catalytic domain of Protein Kinases; Region: PKc; cd00180
657315003944	active site
657315003945	ATP binding site [chemical binding]; other site
657315003946	substrate binding site [chemical binding]; other site
657315003947	activation loop (A-loop); other site
657315003948	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
657315003949	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
657315003950	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
657315003951	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
657315003952	23S rRNA interface [nucleotide binding]; other site
657315003953	L3 interface [polypeptide binding]; other site
657315003954	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
657315003955	Leucine carboxyl methyltransferase; Region: LCM; cl01306
657315003956	putative phosphoketolase; Provisional; Region: PRK05261
657315003957	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
657315003958	TPP-binding site; other site
657315003959	XFP C-terminal domain; Region: XFP_C; pfam09363
657315003960	Cupin domain; Region: Cupin_2; pfam07883
657315003961	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315003962	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315003963	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315003964	dimer interface [polypeptide binding]; other site
657315003965	putative CheW interface [polypeptide binding]; other site
657315003966	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657315003967	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315003968	active site
657315003969	phosphorylation site [posttranslational modification]
657315003970	intermolecular recognition site; other site
657315003971	dimerization interface [polypeptide binding]; other site
657315003972	LytTr DNA-binding domain; Region: LytTR; pfam04397
657315003973	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
657315003974	ATP binding site [chemical binding]; other site
657315003975	Mg2+ binding site [ion binding]; other site
657315003976	G-X-G motif; other site
657315003977	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
657315003978	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
657315003979	Walker A/P-loop; other site
657315003980	ATP binding site [chemical binding]; other site
657315003981	Q-loop/lid; other site
657315003982	ABC transporter signature motif; other site
657315003983	Walker B; other site
657315003984	D-loop; other site
657315003985	H-loop/switch region; other site
657315003986	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315003987	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
657315003988	Walker A/P-loop; other site
657315003989	ATP binding site [chemical binding]; other site
657315003990	Q-loop/lid; other site
657315003991	ABC transporter signature motif; other site
657315003992	Walker B; other site
657315003993	D-loop; other site
657315003994	H-loop/switch region; other site
657315003995	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657315003996	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657315003997	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657315003998	Interdomain contacts; other site
657315003999	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
657315004000	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
657315004001	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
657315004002	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
657315004003	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
657315004004	FMN binding site [chemical binding]; other site
657315004005	active site
657315004006	catalytic residues [active]
657315004007	substrate binding site [chemical binding]; other site
657315004008	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
657315004009	substrate binding site [chemical binding]; other site
657315004010	active site
657315004011	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
657315004012	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
657315004013	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
657315004014	active site
657315004015	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
657315004016	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
657315004017	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
657315004018	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
657315004019	active site
657315004020	metal binding site [ion binding]; metal-binding site
657315004021	homotetramer interface [polypeptide binding]; other site
657315004022	PAS domain; Region: PAS_9; pfam13426
657315004023	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
657315004024	putative active site [active]
657315004025	heme pocket [chemical binding]; other site
657315004026	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315004027	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315004028	metal binding site [ion binding]; metal-binding site
657315004029	active site
657315004030	I-site; other site
657315004031	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
657315004032	Pyruvate formate lyase 1; Region: PFL1; cd01678
657315004033	coenzyme A binding site [chemical binding]; other site
657315004034	active site
657315004035	catalytic residues [active]
657315004036	glycine loop; other site
657315004037	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
657315004038	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315004039	FeS/SAM binding site; other site
657315004040	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
657315004041	30S subunit binding site; other site
657315004042	EDD domain protein, DegV family; Region: DegV; TIGR00762
657315004043	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
657315004044	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
657315004045	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
657315004046	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
657315004047	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
657315004048	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
657315004049	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
657315004050	putative acyl-acceptor binding pocket; other site
657315004051	PrcB C-terminal; Region: PrcB_C; pfam14343
657315004052	Protein of unknown function (DUF1021); Region: DUF1021; cl01852
657315004053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
657315004054	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
657315004055	NlpC/P60 family; Region: NLPC_P60; pfam00877
657315004056	Yqey-like protein; Region: YqeY; cl17540
657315004057	methionine aminopeptidase; Provisional; Region: PRK12318
657315004058	SEC-C motif; Region: SEC-C; pfam02810
657315004059	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
657315004060	active site
657315004061	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
657315004062	monogalactosyldiacylglycerol synthase; Region: PLN02605
657315004063	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
657315004064	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
657315004065	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315004066	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657315004067	DNA binding site [nucleotide binding]
657315004068	domain linker motif; other site
657315004069	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657315004070	ligand binding site [chemical binding]; other site
657315004071	dimerization interface [polypeptide binding]; other site
657315004072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
657315004073	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
657315004074	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315004075	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657315004076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315004077	dimer interface [polypeptide binding]; other site
657315004078	conserved gate region; other site
657315004079	putative PBP binding loops; other site
657315004080	ABC-ATPase subunit interface; other site
657315004081	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315004082	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315004083	dimer interface [polypeptide binding]; other site
657315004084	conserved gate region; other site
657315004085	putative PBP binding loops; other site
657315004086	ABC-ATPase subunit interface; other site
657315004087	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
657315004088	Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891
657315004089	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
657315004090	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
657315004091	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
657315004092	myosin-cross-reactive antigen; Provisional; Region: PRK13977
657315004093	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657315004094	Coenzyme A binding pocket [chemical binding]; other site
657315004095	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
657315004096	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
657315004097	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
657315004098	shikimate binding site; other site
657315004099	NAD(P) binding site [chemical binding]; other site
657315004100	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
657315004101	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657315004102	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657315004103	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
657315004104	putative dimerization interface [polypeptide binding]; other site
657315004105	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657315004106	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657315004107	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
657315004108	dimerization interface [polypeptide binding]; other site
657315004109	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
657315004110	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
657315004111	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
657315004112	shikimate binding site; other site
657315004113	NAD(P) binding site [chemical binding]; other site
657315004114	Major Facilitator Superfamily; Region: MFS_1; pfam07690
657315004115	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
657315004116	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
657315004117	active site
657315004118	catalytic residue [active]
657315004119	dimer interface [polypeptide binding]; other site
657315004120	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
657315004121	DctM-like transporters; Region: DctM; pfam06808
657315004122	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
657315004123	Chorismate mutase type II; Region: CM_2; cl00693
657315004124	shikimate kinase; Reviewed; Region: aroK; PRK00131
657315004125	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
657315004126	ADP binding site [chemical binding]; other site
657315004127	magnesium binding site [ion binding]; other site
657315004128	putative shikimate binding site; other site
657315004129	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
657315004130	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
657315004131	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
657315004132	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
657315004133	Beta-lactamase; Region: Beta-lactamase; pfam00144
657315004134	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
657315004135	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
657315004136	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
657315004137	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
657315004138	LytTr DNA-binding domain; Region: LytTR; smart00850
657315004139	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
657315004140	Protein of unknown function (DUF975); Region: DUF975; cl10504
657315004141	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
657315004142	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
657315004143	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
657315004144	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
657315004145	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
657315004146	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
657315004147	RNA binding site [nucleotide binding]; other site
657315004148	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
657315004149	Predicted membrane protein [Function unknown]; Region: COG3601
657315004150	YcxB-like protein; Region: YcxB; pfam14317
657315004151	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
657315004152	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
657315004153	Glycoprotease family; Region: Peptidase_M22; pfam00814
657315004154	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
657315004155	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657315004156	Coenzyme A binding pocket [chemical binding]; other site
657315004157	ribonuclease Z; Reviewed; Region: PRK00055
657315004158	UGMP family protein; Validated; Region: PRK09604
657315004159	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
657315004160	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
657315004161	substrate binding site; other site
657315004162	dimer interface; other site
657315004163	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
657315004164	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657315004165	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
657315004166	FtsX-like permease family; Region: FtsX; pfam02687
657315004167	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657315004168	FtsX-like permease family; Region: FtsX; pfam02687
657315004169	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315004170	Walker A/P-loop; other site
657315004171	ATP binding site [chemical binding]; other site
657315004172	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315004173	H-loop/switch region; other site
657315004174	ABC transporter; Region: ABC_tran_2; pfam12848
657315004175	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
657315004176	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
657315004177	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
657315004178	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315004179	Walker A/P-loop; other site
657315004180	ATP binding site [chemical binding]; other site
657315004181	Q-loop/lid; other site
657315004182	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657315004183	ABC transporter signature motif; other site
657315004184	Walker B; other site
657315004185	ABC transporter; Region: ABC_tran_2; pfam12848
657315004186	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657315004187	Predicted transcriptional regulators [Transcription]; Region: COG1725
657315004188	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657315004189	DNA-binding site [nucleotide binding]; DNA binding site
657315004190	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
657315004191	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
657315004192	Walker A/P-loop; other site
657315004193	ATP binding site [chemical binding]; other site
657315004194	Q-loop/lid; other site
657315004195	ABC transporter signature motif; other site
657315004196	Walker B; other site
657315004197	D-loop; other site
657315004198	H-loop/switch region; other site
657315004199	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
657315004200	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315004201	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315004202	metal binding site [ion binding]; metal-binding site
657315004203	active site
657315004204	I-site; other site
657315004205	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
657315004206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657315004207	putative substrate translocation pore; other site
657315004208	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
657315004209	Na2 binding site [ion binding]; other site
657315004210	putative substrate binding site 1 [chemical binding]; other site
657315004211	Na binding site 1 [ion binding]; other site
657315004212	putative substrate binding site 2 [chemical binding]; other site
657315004213	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315004214	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
657315004215	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657315004216	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657315004217	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657315004218	dimerization interface [polypeptide binding]; other site
657315004219	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
657315004220	active site
657315004221	catalytic triad [active]
657315004222	oxyanion hole [active]
657315004223	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
657315004224	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315004225	motif II; other site
657315004226	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
657315004227	Part of AAA domain; Region: AAA_19; pfam13245
657315004228	Family description; Region: UvrD_C_2; pfam13538
657315004229	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
657315004230	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
657315004231	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315004232	DNA binding site [nucleotide binding]
657315004233	active site
657315004234	Int/Topo IB signature motif; other site
657315004235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315004236	S-adenosylmethionine binding site [chemical binding]; other site
657315004237	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657315004238	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
657315004239	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315004240	non-specific DNA binding site [nucleotide binding]; other site
657315004241	salt bridge; other site
657315004242	sequence-specific DNA binding site [nucleotide binding]; other site
657315004243	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315004244	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
657315004245	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
657315004246	transcription termination factor Rho; Provisional; Region: PRK12608
657315004247	RNA binding site [nucleotide binding]; other site
657315004248	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657315004249	Walker A motif; other site
657315004250	ATP binding site [chemical binding]; other site
657315004251	Walker B motif; other site
657315004252	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
657315004253	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
657315004254	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
657315004255	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315004256	S-adenosylmethionine binding site [chemical binding]; other site
657315004257	peptide chain release factor 1; Validated; Region: prfA; PRK00591
657315004258	This domain is found in peptide chain release factors; Region: PCRF; smart00937
657315004259	RF-1 domain; Region: RF-1; pfam00472
657315004260	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
657315004261	Divergent AAA domain; Region: AAA_4; pfam04326
657315004262	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
657315004263	putative DNA binding site [nucleotide binding]; other site
657315004264	putative Zn2+ binding site [ion binding]; other site
657315004265	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
657315004266	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657315004267	active site
657315004268	HIGH motif; other site
657315004269	nucleotide binding site [chemical binding]; other site
657315004270	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657315004271	active site
657315004272	KMSKS motif; other site
657315004273	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
657315004274	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
657315004275	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
657315004276	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
657315004277	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657315004278	DNA-binding site [nucleotide binding]; DNA binding site
657315004279	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657315004280	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315004281	homodimer interface [polypeptide binding]; other site
657315004282	catalytic residue [active]
657315004283	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
657315004284	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
657315004285	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
657315004286	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
657315004287	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
657315004288	Walker A/P-loop; other site
657315004289	ATP binding site [chemical binding]; other site
657315004290	Q-loop/lid; other site
657315004291	ABC transporter signature motif; other site
657315004292	Walker B; other site
657315004293	D-loop; other site
657315004294	H-loop/switch region; other site
657315004295	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
657315004296	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
657315004297	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
657315004298	Walker A/P-loop; other site
657315004299	ATP binding site [chemical binding]; other site
657315004300	Q-loop/lid; other site
657315004301	ABC transporter signature motif; other site
657315004302	Walker B; other site
657315004303	D-loop; other site
657315004304	H-loop/switch region; other site
657315004305	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
657315004306	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
657315004307	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315004308	dimer interface [polypeptide binding]; other site
657315004309	conserved gate region; other site
657315004310	putative PBP binding loops; other site
657315004311	ABC-ATPase subunit interface; other site
657315004312	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
657315004313	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315004314	dimer interface [polypeptide binding]; other site
657315004315	conserved gate region; other site
657315004316	putative PBP binding loops; other site
657315004317	ABC-ATPase subunit interface; other site
657315004318	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
657315004319	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
657315004320	metal binding site [ion binding]; metal-binding site
657315004321	argininosuccinate synthase; Provisional; Region: PRK13820
657315004322	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
657315004323	ANP binding site [chemical binding]; other site
657315004324	Substrate Binding Site II [chemical binding]; other site
657315004325	Substrate Binding Site I [chemical binding]; other site
657315004326	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
657315004327	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
657315004328	putative acetyltransferase; Provisional; Region: PRK03624
657315004329	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657315004330	Coenzyme A binding pocket [chemical binding]; other site
657315004331	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
657315004332	heterotetramer interface [polypeptide binding]; other site
657315004333	active site pocket [active]
657315004334	cleavage site
657315004335	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
657315004336	feedback inhibition sensing region; other site
657315004337	homohexameric interface [polypeptide binding]; other site
657315004338	nucleotide binding site [chemical binding]; other site
657315004339	N-acetyl-L-glutamate binding site [chemical binding]; other site
657315004340	acetylornithine aminotransferase; Provisional; Region: PRK02627
657315004341	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
657315004342	inhibitor-cofactor binding pocket; inhibition site
657315004343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315004344	catalytic residue [active]
657315004345	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
657315004346	SLBB domain; Region: SLBB; pfam10531
657315004347	comEA protein; Region: comE; TIGR01259
657315004348	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315004349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315004350	active site
657315004351	phosphorylation site [posttranslational modification]
657315004352	intermolecular recognition site; other site
657315004353	dimerization interface [polypeptide binding]; other site
657315004354	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315004355	DNA binding site [nucleotide binding]
657315004356	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
657315004357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315004358	dimer interface [polypeptide binding]; other site
657315004359	phosphorylation site [posttranslational modification]
657315004360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315004361	ATP binding site [chemical binding]; other site
657315004362	Mg2+ binding site [ion binding]; other site
657315004363	G-X-G motif; other site
657315004364	Sporulation and spore germination; Region: Germane; pfam10646
657315004365	Sporulation and spore germination; Region: Germane; pfam10646
657315004366	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
657315004367	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
657315004368	germination protease; Provisional; Region: PRK12362
657315004369	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
657315004370	stage II sporulation protein P; Region: spore_II_P; TIGR02867
657315004371	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
657315004372	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
657315004373	active site
657315004374	dimer interface [polypeptide binding]; other site
657315004375	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
657315004376	Ligand Binding Site [chemical binding]; other site
657315004377	Molecular Tunnel; other site
657315004378	Protein of unknown function (DUF975); Region: DUF975; cl10504
657315004379	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
657315004380	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
657315004381	active site
657315004382	catalytic triad [active]
657315004383	AAA domain; Region: AAA_31; pfam13614
657315004384	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657315004385	P-loop; other site
657315004386	Magnesium ion binding site [ion binding]; other site
657315004387	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657315004388	Magnesium ion binding site [ion binding]; other site
657315004389	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315004390	sequence-specific DNA binding site [nucleotide binding]; other site
657315004391	salt bridge; other site
657315004392	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657315004393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315004394	active site
657315004395	phosphorylation site [posttranslational modification]
657315004396	intermolecular recognition site; other site
657315004397	dimerization interface [polypeptide binding]; other site
657315004398	LytTr DNA-binding domain; Region: LytTR; pfam04397
657315004399	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315004400	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315004401	ATP binding site [chemical binding]; other site
657315004402	Mg2+ binding site [ion binding]; other site
657315004403	G-X-G motif; other site
657315004404	Accessory gene regulator B; Region: AgrB; pfam04647
657315004405	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
657315004406	HSP70 interaction site [polypeptide binding]; other site
657315004407	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
657315004408	phosphopeptide binding site; other site
657315004409	active site
657315004410	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
657315004411	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
657315004412	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
657315004413	nucleotide binding site [chemical binding]; other site
657315004414	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
657315004415	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
657315004416	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
657315004417	Transposase domain (DUF772); Region: DUF772; pfam05598
657315004418	Domain of unknown function (DUF1910); Region: DUF1910; pfam08928
657315004419	GAD-like domain; Region: GAD-like; pfam08887
657315004420	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
657315004421	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
657315004422	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
657315004423	Transposase IS200 like; Region: Y1_Tnp; pfam01797
657315004424	Transposase IS200 like; Region: Y1_Tnp; cl00848
657315004425	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
657315004426	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315004427	salt bridge; other site
657315004428	non-specific DNA binding site [nucleotide binding]; other site
657315004429	sequence-specific DNA binding site [nucleotide binding]; other site
657315004430	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657315004431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315004432	active site
657315004433	phosphorylation site [posttranslational modification]
657315004434	intermolecular recognition site; other site
657315004435	dimerization interface [polypeptide binding]; other site
657315004436	LytTr DNA-binding domain; Region: LytTR; cl04498
657315004437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315004438	ATP binding site [chemical binding]; other site
657315004439	Mg2+ binding site [ion binding]; other site
657315004440	G-X-G motif; other site
657315004441	sporulation sigma factor SigF; Validated; Region: PRK05572
657315004442	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
657315004443	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315004444	active site
657315004445	Int/Topo IB signature motif; other site
657315004446	DNA binding site [nucleotide binding]
657315004447	TIR domain; Region: TIR_2; pfam13676
657315004448	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
657315004449	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
657315004450	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657315004451	catalytic residues [active]
657315004452	catalytic nucleophile [active]
657315004453	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315004454	Recombinase; Region: Recombinase; pfam07508
657315004455	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315004456	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315004457	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657315004458	catalytic residues [active]
657315004459	catalytic nucleophile [active]
657315004460	Recombinase; Region: Recombinase; pfam07508
657315004461	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315004462	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315004463	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657315004464	catalytic residues [active]
657315004465	catalytic nucleophile [active]
657315004466	Recombinase; Region: Recombinase; pfam07508
657315004467	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315004468	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
657315004469	nudix motif; other site
657315004470	FeoA domain; Region: FeoA; pfam04023
657315004471	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
657315004472	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
657315004473	G1 box; other site
657315004474	GTP/Mg2+ binding site [chemical binding]; other site
657315004475	Switch I region; other site
657315004476	G2 box; other site
657315004477	G3 box; other site
657315004478	Switch II region; other site
657315004479	G4 box; other site
657315004480	G5 box; other site
657315004481	Nucleoside recognition; Region: Gate; pfam07670
657315004482	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
657315004483	Nucleoside recognition; Region: Gate; pfam07670
657315004484	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
657315004485	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
657315004486	chaperone protein DnaJ; Provisional; Region: PRK14277
657315004487	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
657315004488	HSP70 interaction site [polypeptide binding]; other site
657315004489	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
657315004490	substrate binding site [polypeptide binding]; other site
657315004491	dimer interface [polypeptide binding]; other site
657315004492	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
657315004493	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
657315004494	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657315004495	catalytic residue [active]
657315004496	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
657315004497	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315004498	motif II; other site
657315004499	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
657315004500	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315004501	Walker A/P-loop; other site
657315004502	ATP binding site [chemical binding]; other site
657315004503	Q-loop/lid; other site
657315004504	ABC transporter signature motif; other site
657315004505	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657315004506	ABC transporter; Region: ABC_tran_2; pfam12848
657315004507	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657315004508	PAS domain; Region: PAS_9; pfam13426
657315004509	PAS fold; Region: PAS_3; pfam08447
657315004510	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315004511	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315004512	metal binding site [ion binding]; metal-binding site
657315004513	active site
657315004514	I-site; other site
657315004515	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315004516	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315004517	metal binding site [ion binding]; metal-binding site
657315004518	active site
657315004519	I-site; other site
657315004520	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
657315004521	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
657315004522	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
657315004523	dimer interface [polypeptide binding]; other site
657315004524	PYR/PP interface [polypeptide binding]; other site
657315004525	TPP binding site [chemical binding]; other site
657315004526	substrate binding site [chemical binding]; other site
657315004527	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
657315004528	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
657315004529	Domain of unknown function; Region: EKR; pfam10371
657315004530	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657315004531	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
657315004532	TPP-binding site [chemical binding]; other site
657315004533	dimer interface [polypeptide binding]; other site
657315004534	phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417
657315004535	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
657315004536	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
657315004537	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
657315004538	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
657315004539	dimerization domain swap beta strand [polypeptide binding]; other site
657315004540	regulatory protein interface [polypeptide binding]; other site
657315004541	active site
657315004542	regulatory phosphorylation site [posttranslational modification]; other site
657315004543	transcriptional antiterminator BglG; Provisional; Region: PRK09772
657315004544	CAT RNA binding domain; Region: CAT_RBD; smart01061
657315004545	PRD domain; Region: PRD; pfam00874
657315004546	PRD domain; Region: PRD; pfam00874
657315004547	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
657315004548	HPr interaction site; other site
657315004549	glycerol kinase (GK) interaction site [polypeptide binding]; other site
657315004550	active site
657315004551	phosphorylation site [posttranslational modification]
657315004552	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
657315004553	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
657315004554	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
657315004555	active site turn [active]
657315004556	phosphorylation site [posttranslational modification]
657315004557	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
657315004558	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
657315004559	DRTGG domain; Region: DRTGG; pfam07085
657315004560	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
657315004561	DHH family; Region: DHH; pfam01368
657315004562	DHHA2 domain; Region: DHHA2; pfam02833
657315004563	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657315004564	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315004565	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315004566	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315004567	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
657315004568	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
657315004569	homodimer interface [polypeptide binding]; other site
657315004570	substrate-cofactor binding pocket; other site
657315004571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315004572	catalytic residue [active]
657315004573	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
657315004574	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
657315004575	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
657315004576	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
657315004577	active site residue [active]
657315004578	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
657315004579	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
657315004580	Ligand Binding Site [chemical binding]; other site
657315004581	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
657315004582	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
657315004583	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
657315004584	putative active site [active]
657315004585	putative catalytic site [active]
657315004586	GTP-binding protein LepA; Provisional; Region: PRK05433
657315004587	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
657315004588	G1 box; other site
657315004589	putative GEF interaction site [polypeptide binding]; other site
657315004590	GTP/Mg2+ binding site [chemical binding]; other site
657315004591	Switch I region; other site
657315004592	G2 box; other site
657315004593	G3 box; other site
657315004594	Switch II region; other site
657315004595	G4 box; other site
657315004596	G5 box; other site
657315004597	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
657315004598	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
657315004599	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
657315004600	TspO/MBR family; Region: TspO_MBR; cl01379
657315004601	TspO/MBR family; Region: TspO_MBR; cl01379
657315004602	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657315004603	4Fe-4S binding domain; Region: Fer4; pfam00037
657315004604	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
657315004605	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
657315004606	4Fe-4S binding domain; Region: Fer4; pfam00037
657315004607	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
657315004608	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
657315004609	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
657315004610	[FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956
657315004611	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315004612	FeS/SAM binding site; other site
657315004613	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
657315004614	[FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955
657315004615	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315004616	FeS/SAM binding site; other site
657315004617	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
657315004618	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
657315004619	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
657315004620	G1 box; other site
657315004621	GTP/Mg2+ binding site [chemical binding]; other site
657315004622	Switch I region; other site
657315004623	G2 box; other site
657315004624	Switch II region; other site
657315004625	G3 box; other site
657315004626	G4 box; other site
657315004627	G5 box; other site
657315004628	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
657315004629	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
657315004630	dimer interface [polypeptide binding]; other site
657315004631	active site
657315004632	metal binding site [ion binding]; metal-binding site
657315004633	heat shock protein 90; Provisional; Region: PRK05218
657315004634	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315004635	ATP binding site [chemical binding]; other site
657315004636	Mg2+ binding site [ion binding]; other site
657315004637	G-X-G motif; other site
657315004638	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
657315004639	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
657315004640	NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179
657315004641	putative active site [active]
657315004642	metal binding site [ion binding]; metal-binding site
657315004643	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
657315004644	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657315004645	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
657315004646	pyruvate phosphate dikinase; Provisional; Region: PRK09279
657315004647	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
657315004648	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
657315004649	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
657315004650	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
657315004651	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
657315004652	Flavodoxin domain; Region: Flavodoxin_5; cl17428
657315004653	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
657315004654	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
657315004655	Erythromycin esterase; Region: Erythro_esteras; pfam05139
657315004656	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
657315004657	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
657315004658	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
657315004659	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
657315004660	active site
657315004661	metal binding site [ion binding]; metal-binding site
657315004662	DNA binding site [nucleotide binding]
657315004663	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
657315004664	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315004665	AAA domain; Region: AAA_23; pfam13476
657315004666	Walker A/P-loop; other site
657315004667	ATP binding site [chemical binding]; other site
657315004668	Q-loop/lid; other site
657315004669	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
657315004670	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315004671	ABC transporter signature motif; other site
657315004672	Walker B; other site
657315004673	D-loop; other site
657315004674	H-loop/switch region; other site
657315004675	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
657315004676	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
657315004677	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657315004678	catalytic residue [active]
657315004679	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
657315004680	MarR family; Region: MarR_2; pfam12802
657315004681	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
657315004682	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315004683	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315004684	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315004685	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315004686	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315004687	Walker A/P-loop; other site
657315004688	ATP binding site [chemical binding]; other site
657315004689	Q-loop/lid; other site
657315004690	ABC transporter signature motif; other site
657315004691	Walker B; other site
657315004692	D-loop; other site
657315004693	H-loop/switch region; other site
657315004694	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
657315004695	MarR family; Region: MarR_2; pfam12802
657315004696	Predicted permeases [General function prediction only]; Region: COG0730
657315004697	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
657315004698	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
657315004699	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
657315004700	DctM-like transporters; Region: DctM; pfam06808
657315004701	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
657315004702	YcxB-like protein; Region: YcxB; pfam14317
657315004703	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
657315004704	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315004705	dimerization interface [polypeptide binding]; other site
657315004706	Histidine kinase; Region: His_kinase; pfam06580
657315004707	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315004708	ATP binding site [chemical binding]; other site
657315004709	Mg2+ binding site [ion binding]; other site
657315004710	G-X-G motif; other site
657315004711	Response regulator receiver domain; Region: Response_reg; pfam00072
657315004712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315004713	active site
657315004714	phosphorylation site [posttranslational modification]
657315004715	intermolecular recognition site; other site
657315004716	dimerization interface [polypeptide binding]; other site
657315004717	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315004718	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315004719	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315004720	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
657315004721	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
657315004722	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
657315004723	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657315004724	putative substrate translocation pore; other site
657315004725	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
657315004726	prolyl-tRNA synthetase; Provisional; Region: PRK09194
657315004727	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
657315004728	motif 1; other site
657315004729	dimer interface [polypeptide binding]; other site
657315004730	active site
657315004731	motif 2; other site
657315004732	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
657315004733	putative deacylase active site [active]
657315004734	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
657315004735	active site
657315004736	motif 3; other site
657315004737	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
657315004738	anticodon binding site; other site
657315004739	Divergent AAA domain; Region: AAA_4; pfam04326
657315004740	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
657315004741	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
657315004742	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
657315004743	active site
657315004744	SAM binding site [chemical binding]; other site
657315004745	homodimer interface [polypeptide binding]; other site
657315004746	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
657315004747	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
657315004748	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
657315004749	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
657315004750	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
657315004751	active site
657315004752	SAM binding site [chemical binding]; other site
657315004753	homodimer interface [polypeptide binding]; other site
657315004754	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
657315004755	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
657315004756	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
657315004757	active site
657315004758	putative homodimer interface [polypeptide binding]; other site
657315004759	SAM binding site [chemical binding]; other site
657315004760	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
657315004761	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315004762	S-adenosylmethionine binding site [chemical binding]; other site
657315004763	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
657315004764	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657315004765	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
657315004766	catalytic triad [active]
657315004767	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
657315004768	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315004769	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315004770	dimer interface [polypeptide binding]; other site
657315004771	phosphorylation site [posttranslational modification]
657315004772	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315004773	ATP binding site [chemical binding]; other site
657315004774	Mg2+ binding site [ion binding]; other site
657315004775	G-X-G motif; other site
657315004776	Response regulator receiver domain; Region: Response_reg; pfam00072
657315004777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315004778	active site
657315004779	phosphorylation site [posttranslational modification]
657315004780	intermolecular recognition site; other site
657315004781	dimerization interface [polypeptide binding]; other site
657315004782	Coat F domain; Region: Coat_F; pfam07875
657315004783	hypothetical protein; Provisional; Region: PRK10410
657315004784	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
657315004785	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315004786	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315004787	Walker A/P-loop; other site
657315004788	ATP binding site [chemical binding]; other site
657315004789	Q-loop/lid; other site
657315004790	ABC transporter signature motif; other site
657315004791	Walker B; other site
657315004792	D-loop; other site
657315004793	H-loop/switch region; other site
657315004794	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315004795	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315004796	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315004797	Walker A/P-loop; other site
657315004798	ATP binding site [chemical binding]; other site
657315004799	Q-loop/lid; other site
657315004800	ABC transporter signature motif; other site
657315004801	Walker B; other site
657315004802	D-loop; other site
657315004803	H-loop/switch region; other site
657315004804	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
657315004805	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
657315004806	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
657315004807	putative deacylase active site [active]
657315004808	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
657315004809	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
657315004810	active site
657315004811	metal binding site [ion binding]; metal-binding site
657315004812	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
657315004813	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657315004814	Coenzyme A binding pocket [chemical binding]; other site
657315004815	EDD domain protein, DegV family; Region: DegV; TIGR00762
657315004816	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
657315004817	SdpI/YhfL protein family; Region: SdpI; pfam13630
657315004818	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315004819	Radical SAM superfamily; Region: Radical_SAM; pfam04055
657315004820	FeS/SAM binding site; other site
657315004821	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315004822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315004823	active site
657315004824	phosphorylation site [posttranslational modification]
657315004825	intermolecular recognition site; other site
657315004826	dimerization interface [polypeptide binding]; other site
657315004827	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315004828	DNA binding site [nucleotide binding]
657315004829	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
657315004830	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
657315004831	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
657315004832	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315004833	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315004834	dimerization interface [polypeptide binding]; other site
657315004835	Histidine kinase; Region: His_kinase; pfam06580
657315004836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315004837	ATP binding site [chemical binding]; other site
657315004838	Mg2+ binding site [ion binding]; other site
657315004839	G-X-G motif; other site
657315004840	Response regulator receiver domain; Region: Response_reg; pfam00072
657315004841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315004842	active site
657315004843	phosphorylation site [posttranslational modification]
657315004844	intermolecular recognition site; other site
657315004845	dimerization interface [polypeptide binding]; other site
657315004846	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657315004847	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315004848	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315004849	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657315004850	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
657315004851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315004852	dimer interface [polypeptide binding]; other site
657315004853	conserved gate region; other site
657315004854	putative PBP binding loops; other site
657315004855	ABC-ATPase subunit interface; other site
657315004856	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315004857	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315004858	dimer interface [polypeptide binding]; other site
657315004859	conserved gate region; other site
657315004860	putative PBP binding loops; other site
657315004861	ABC-ATPase subunit interface; other site
657315004862	NifU-like domain; Region: NifU; cl00484
657315004863	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
657315004864	active site
657315004865	catalytic site [active]
657315004866	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
657315004867	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
657315004868	FeoA domain; Region: FeoA; pfam04023
657315004869	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
657315004870	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
657315004871	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
657315004872	G1 box; other site
657315004873	GTP/Mg2+ binding site [chemical binding]; other site
657315004874	Switch I region; other site
657315004875	G2 box; other site
657315004876	G3 box; other site
657315004877	Switch II region; other site
657315004878	G4 box; other site
657315004879	G5 box; other site
657315004880	Nucleoside recognition; Region: Gate; pfam07670
657315004881	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
657315004882	Nucleoside recognition; Region: Gate; pfam07670
657315004883	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
657315004884	metal binding site 2 [ion binding]; metal-binding site
657315004885	putative DNA binding helix; other site
657315004886	structural Zn2+ binding site [ion binding]; other site
657315004887	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
657315004888	metal-binding site [ion binding]
657315004889	N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755
657315004890	catalytic domain interface [polypeptide binding]; other site
657315004891	putative homodimer interface [polypeptide binding]; other site
657315004892	Protein of unknown function, DUF608; Region: DUF608; pfam04685
657315004893	N-terminal-like domain of Paenibacillus sp. YM-1 Laminaribiose Phosphorylase and similar proteins; Region: GH94N_LBP_like; cd11749
657315004894	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
657315004895	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315004896	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315004897	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315004898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315004899	dimer interface [polypeptide binding]; other site
657315004900	conserved gate region; other site
657315004901	putative PBP binding loops; other site
657315004902	ABC-ATPase subunit interface; other site
657315004903	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315004904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315004905	dimer interface [polypeptide binding]; other site
657315004906	conserved gate region; other site
657315004907	putative PBP binding loops; other site
657315004908	ABC-ATPase subunit interface; other site
657315004909	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
657315004910	classical (c) SDRs; Region: SDR_c; cd05233
657315004911	NAD(P) binding site [chemical binding]; other site
657315004912	active site
657315004913	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
657315004914	metal-binding site [ion binding]
657315004915	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
657315004916	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
657315004917	Soluble P-type ATPase [General function prediction only]; Region: COG4087
657315004918	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
657315004919	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
657315004920	Soluble P-type ATPase [General function prediction only]; Region: COG4087
657315004921	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
657315004922	Serine hydrolase (FSH1); Region: FSH1; pfam03959
657315004923	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315004924	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315004925	metal binding site [ion binding]; metal-binding site
657315004926	active site
657315004927	I-site; other site
657315004928	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
657315004929	4Fe-4S binding domain; Region: Fer4; pfam00037
657315004930	4Fe-4S binding domain; Region: Fer4; pfam00037
657315004931	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
657315004932	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315004933	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
657315004934	active site
657315004935	motif I; other site
657315004936	motif II; other site
657315004937	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315004938	motif II; other site
657315004939	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
657315004940	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
657315004941	oligomerisation interface [polypeptide binding]; other site
657315004942	mobile loop; other site
657315004943	roof hairpin; other site
657315004944	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
657315004945	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
657315004946	ring oligomerisation interface [polypeptide binding]; other site
657315004947	ATP/Mg binding site [chemical binding]; other site
657315004948	stacking interactions; other site
657315004949	hinge regions; other site
657315004950	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
657315004951	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657315004952	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315004953	homodimer interface [polypeptide binding]; other site
657315004954	catalytic residue [active]
657315004955	Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546
657315004956	dinuclear metal binding motif [ion binding]; other site
657315004957	CotJB protein; Region: CotJB; pfam12652
657315004958	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
657315004959	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657315004960	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
657315004961	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
657315004962	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
657315004963	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
657315004964	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315004965	dimer interface [polypeptide binding]; other site
657315004966	putative CheW interface [polypeptide binding]; other site
657315004967	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
657315004968	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
657315004969	active site
657315004970	HIGH motif; other site
657315004971	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
657315004972	active site
657315004973	KMSKS motif; other site
657315004974	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
657315004975	Part of AAA domain; Region: AAA_19; pfam13245
657315004976	AAA domain; Region: AAA_14; pfam13173
657315004977	Family description; Region: UvrD_C_2; pfam13538
657315004978	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
657315004979	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
657315004980	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
657315004981	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
657315004982	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
657315004983	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
657315004984	active site
657315004985	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
657315004986	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657315004987	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657315004988	DNA binding residues [nucleotide binding]
657315004989	DNA topoisomerase I; Validated; Region: PRK05582
657315004990	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
657315004991	active site
657315004992	interdomain interaction site; other site
657315004993	putative metal-binding site [ion binding]; other site
657315004994	nucleotide binding site [chemical binding]; other site
657315004995	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
657315004996	domain I; other site
657315004997	DNA binding groove [nucleotide binding]
657315004998	phosphate binding site [ion binding]; other site
657315004999	domain II; other site
657315005000	domain III; other site
657315005001	nucleotide binding site [chemical binding]; other site
657315005002	catalytic site [active]
657315005003	domain IV; other site
657315005004	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
657315005005	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
657315005006	transcriptional repressor CodY; Validated; Region: PRK04158
657315005007	CodY GAF-like domain; Region: CodY; pfam06018
657315005008	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
657315005009	flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396
657315005010	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
657315005011	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
657315005012	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
657315005013	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
657315005014	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
657315005015	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
657315005016	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
657315005017	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
657315005018	MgtE intracellular N domain; Region: MgtE_N; cl15244
657315005019	FliG C-terminal domain; Region: FliG_C; pfam01706
657315005020	Flagellar assembly protein FliH; Region: FliH; pfam02108
657315005021	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
657315005022	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
657315005023	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
657315005024	Walker A motif/ATP binding site; other site
657315005025	Walker B motif; other site
657315005026	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
657315005027	Uncharacterized conserved protein [Function unknown]; Region: COG3334
657315005028	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
657315005029	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
657315005030	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
657315005031	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
657315005032	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
657315005033	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
657315005034	Flagellar protein (FlbD); Region: FlbD; pfam06289
657315005035	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
657315005036	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
657315005037	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
657315005038	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
657315005039	CheC-like family; Region: CheC; pfam04509
657315005040	CheC-like family; Region: CheC; pfam04509
657315005041	flagellar motor switch protein FliN; Region: fliN; TIGR02480
657315005042	Response regulator receiver domain; Region: Response_reg; pfam00072
657315005043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315005044	active site
657315005045	phosphorylation site [posttranslational modification]
657315005046	intermolecular recognition site; other site
657315005047	dimerization interface [polypeptide binding]; other site
657315005048	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
657315005049	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
657315005050	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
657315005051	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
657315005052	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
657315005053	FHIPEP family; Region: FHIPEP; pfam00771
657315005054	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
657315005055	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657315005056	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
657315005057	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
657315005058	P-loop; other site
657315005059	Flagellar protein YcgR; Region: YcgR_2; pfam12945
657315005060	PilZ domain; Region: PilZ; pfam07238
657315005061	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
657315005062	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315005063	active site
657315005064	phosphorylation site [posttranslational modification]
657315005065	intermolecular recognition site; other site
657315005066	dimerization interface [polypeptide binding]; other site
657315005067	CheB methylesterase; Region: CheB_methylest; pfam01339
657315005068	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
657315005069	putative binding surface; other site
657315005070	active site
657315005071	P2 response regulator binding domain; Region: P2; pfam07194
657315005072	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
657315005073	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
657315005074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315005075	ATP binding site [chemical binding]; other site
657315005076	Mg2+ binding site [ion binding]; other site
657315005077	G-X-G motif; other site
657315005078	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
657315005079	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
657315005080	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
657315005081	CheC-like family; Region: CheC; pfam04509
657315005082	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
657315005083	CheC-like family; Region: CheC; pfam04509
657315005084	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488
657315005085	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
657315005086	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657315005087	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
657315005088	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657315005089	DNA binding residues [nucleotide binding]
657315005090	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
657315005091	rRNA interaction site [nucleotide binding]; other site
657315005092	S8 interaction site; other site
657315005093	putative laminin-1 binding site; other site
657315005094	elongation factor Ts; Provisional; Region: tsf; PRK09377
657315005095	UBA/TS-N domain; Region: UBA; pfam00627
657315005096	Elongation factor TS; Region: EF_TS; pfam00889
657315005097	Elongation factor TS; Region: EF_TS; pfam00889
657315005098	Cupin domain; Region: Cupin_2; pfam07883
657315005099	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315005100	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315005101	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315005102	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
657315005103	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
657315005104	Ca binding site [ion binding]; other site
657315005105	active site
657315005106	catalytic site [active]
657315005107	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
657315005108	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
657315005109	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
657315005110	PhoU domain; Region: PhoU; pfam01895
657315005111	PhoU domain; Region: PhoU; pfam01895
657315005112	Domain of unknown function (DUF368); Region: DUF368; pfam04018
657315005113	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
657315005114	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
657315005115	NodB motif; other site
657315005116	active site
657315005117	catalytic site [active]
657315005118	Zn binding site [ion binding]; other site
657315005119	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
657315005120	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
657315005121	putative nucleotide binding site [chemical binding]; other site
657315005122	uridine monophosphate binding site [chemical binding]; other site
657315005123	homohexameric interface [polypeptide binding]; other site
657315005124	ribosome recycling factor; Reviewed; Region: frr; PRK00083
657315005125	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
657315005126	hinge region; other site
657315005127	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
657315005128	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
657315005129	catalytic residue [active]
657315005130	putative FPP diphosphate  binding site; other site
657315005131	putative FPP binding hydrophobic cleft; other site
657315005132	dimer interface [polypeptide binding]; other site
657315005133	putative IPP diphosphate binding site; other site
657315005134	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
657315005135	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
657315005136	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
657315005137	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
657315005138	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
657315005139	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
657315005140	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
657315005141	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
657315005142	active site
657315005143	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
657315005144	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
657315005145	putative substrate binding region [chemical binding]; other site
657315005146	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
657315005147	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
657315005148	generic binding surface II; other site
657315005149	generic binding surface I; other site
657315005150	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
657315005151	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
657315005152	active site
657315005153	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
657315005154	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
657315005155	active site
657315005156	catalytic site [active]
657315005157	substrate binding site [chemical binding]; other site
657315005158	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
657315005159	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
657315005160	Chorismate mutase type II; Region: CM_2; pfam01817
657315005161	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
657315005162	Prephenate dehydratase; Region: PDT; pfam00800
657315005163	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
657315005164	putative L-Phe binding site [chemical binding]; other site
657315005165	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315005166	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
657315005167	Walker A motif; other site
657315005168	ATP binding site [chemical binding]; other site
657315005169	Walker B motif; other site
657315005170	exopolyphosphatase; Region: exo_poly_only; TIGR03706
657315005171	polyphosphate kinase; Provisional; Region: PRK05443
657315005172	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
657315005173	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
657315005174	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
657315005175	putative domain interface [polypeptide binding]; other site
657315005176	putative active site [active]
657315005177	catalytic site [active]
657315005178	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
657315005179	putative domain interface [polypeptide binding]; other site
657315005180	putative active site [active]
657315005181	catalytic site [active]
657315005182	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
657315005183	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315005184	active site
657315005185	motif I; other site
657315005186	motif II; other site
657315005187	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315005188	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
657315005189	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
657315005190	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
657315005191	active site
657315005192	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
657315005193	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
657315005194	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
657315005195	HAMP domain; Region: HAMP; pfam00672
657315005196	dimerization interface [polypeptide binding]; other site
657315005197	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315005198	dimer interface [polypeptide binding]; other site
657315005199	putative CheW interface [polypeptide binding]; other site
657315005200	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
657315005201	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
657315005202	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
657315005203	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
657315005204	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
657315005205	23S rRNA binding site [nucleotide binding]; other site
657315005206	L21 binding site [polypeptide binding]; other site
657315005207	L13 binding site [polypeptide binding]; other site
657315005208	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
657315005209	PHP domain; Region: PHP; pfam02811
657315005210	active site
657315005211	PHP-associated; Region: PHP_C; pfam13263
657315005212	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657315005213	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315005214	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315005215	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315005216	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
657315005217	UDP-glucose 4-epimerase; Region: PLN02240
657315005218	NAD binding site [chemical binding]; other site
657315005219	homodimer interface [polypeptide binding]; other site
657315005220	active site
657315005221	substrate binding site [chemical binding]; other site
657315005222	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
657315005223	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
657315005224	FMN binding site [chemical binding]; other site
657315005225	substrate binding site [chemical binding]; other site
657315005226	putative catalytic residue [active]
657315005227	ribosome maturation protein RimP; Reviewed; Region: PRK00092
657315005228	Sm and related proteins; Region: Sm_like; cl00259
657315005229	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
657315005230	putative oligomer interface [polypeptide binding]; other site
657315005231	putative RNA binding site [nucleotide binding]; other site
657315005232	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
657315005233	NusA N-terminal domain; Region: NusA_N; pfam08529
657315005234	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
657315005235	RNA binding site [nucleotide binding]; other site
657315005236	homodimer interface [polypeptide binding]; other site
657315005237	NusA-like KH domain; Region: KH_5; pfam13184
657315005238	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
657315005239	G-X-X-G motif; other site
657315005240	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
657315005241	putative RNA binding cleft [nucleotide binding]; other site
657315005242	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
657315005243	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
657315005244	DHH family; Region: DHH; pfam01368
657315005245	DHHA1 domain; Region: DHHA1; pfam02272
657315005246	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
657315005247	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
657315005248	RNA binding site [nucleotide binding]; other site
657315005249	active site
657315005250	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
657315005251	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
657315005252	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
657315005253	active site
657315005254	Riboflavin kinase; Region: Flavokinase; pfam01687
657315005255	Bacterial SH3 domain; Region: SH3_3; pfam08239
657315005256	Bacterial SH3 domain; Region: SH3_3; pfam08239
657315005257	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
657315005258	NlpC/P60 family; Region: NLPC_P60; pfam00877
657315005259	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
657315005260	16S/18S rRNA binding site [nucleotide binding]; other site
657315005261	S13e-L30e interaction site [polypeptide binding]; other site
657315005262	25S rRNA binding site [nucleotide binding]; other site
657315005263	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
657315005264	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
657315005265	RNase E interface [polypeptide binding]; other site
657315005266	trimer interface [polypeptide binding]; other site
657315005267	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
657315005268	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
657315005269	RNase E interface [polypeptide binding]; other site
657315005270	trimer interface [polypeptide binding]; other site
657315005271	active site
657315005272	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
657315005273	putative nucleic acid binding region [nucleotide binding]; other site
657315005274	G-X-X-G motif; other site
657315005275	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
657315005276	RNA binding site [nucleotide binding]; other site
657315005277	domain interface; other site
657315005278	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
657315005279	active site
657315005280	catalytic triad [active]
657315005281	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
657315005282	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
657315005283	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
657315005284	putative active site [active]
657315005285	catalytic site [active]
657315005286	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
657315005287	putative active site [active]
657315005288	catalytic site [active]
657315005289	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
657315005290	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
657315005291	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
657315005292	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
657315005293	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
657315005294	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
657315005295	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
657315005296	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
657315005297	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
657315005298	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
657315005299	carboxyltransferase (CT) interaction site; other site
657315005300	biotinylation site [posttranslational modification]; other site
657315005301	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
657315005302	oxaloacetate decarboxylase; Provisional; Region: PRK12331
657315005303	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
657315005304	active site
657315005305	catalytic residues [active]
657315005306	metal binding site [ion binding]; metal-binding site
657315005307	homodimer binding site [polypeptide binding]; other site
657315005308	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315005309	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315005310	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315005311	Walker A/P-loop; other site
657315005312	ATP binding site [chemical binding]; other site
657315005313	Q-loop/lid; other site
657315005314	ABC transporter signature motif; other site
657315005315	Walker B; other site
657315005316	D-loop; other site
657315005317	H-loop/switch region; other site
657315005318	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
657315005319	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
657315005320	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
657315005321	putative active site [active]
657315005322	flavoprotein, HI0933 family; Region: TIGR00275
657315005323	cytidylate kinase; Provisional; Region: cmk; PRK00023
657315005324	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
657315005325	CMP-binding site; other site
657315005326	The sites determining sugar specificity; other site
657315005327	LytB protein; Region: LYTB; cl00507
657315005328	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
657315005329	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
657315005330	RNA binding site [nucleotide binding]; other site
657315005331	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
657315005332	RNA binding site [nucleotide binding]; other site
657315005333	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
657315005334	RNA binding site [nucleotide binding]; other site
657315005335	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
657315005336	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
657315005337	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
657315005338	RNase_H superfamily; Region: RNase_H_2; pfam13482
657315005339	active site
657315005340	catalytic site [active]
657315005341	substrate binding site [chemical binding]; other site
657315005342	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
657315005343	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
657315005344	SLBB domain; Region: SLBB; pfam10531
657315005345	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657315005346	FMN-binding domain; Region: FMN_bind; cl01081
657315005347	electron transport complex RsxE subunit; Provisional; Region: PRK12405
657315005348	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
657315005349	Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878
657315005350	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657315005351	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
657315005352	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
657315005353	4Fe-4S binding domain; Region: Fer4; pfam00037
657315005354	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
657315005355	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315005356	dimer interface [polypeptide binding]; other site
657315005357	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
657315005358	putative CheW interface [polypeptide binding]; other site
657315005359	Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188
657315005360	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315005361	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315005362	dimer interface [polypeptide binding]; other site
657315005363	putative CheW interface [polypeptide binding]; other site
657315005364	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
657315005365	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
657315005366	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315005367	catalytic residue [active]
657315005368	Chemotaxis phosphatase CheX; Region: CheX; cl15816
657315005369	Response regulator receiver domain; Region: Response_reg; pfam00072
657315005370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315005371	active site
657315005372	phosphorylation site [posttranslational modification]
657315005373	intermolecular recognition site; other site
657315005374	dimerization interface [polypeptide binding]; other site
657315005375	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315005376	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315005377	active site
657315005378	phosphorylation site [posttranslational modification]
657315005379	intermolecular recognition site; other site
657315005380	dimerization interface [polypeptide binding]; other site
657315005381	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315005382	DNA binding site [nucleotide binding]
657315005383	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
657315005384	dimer interface [polypeptide binding]; other site
657315005385	Citrate synthase; Region: Citrate_synt; pfam00285
657315005386	active site
657315005387	citrylCoA binding site [chemical binding]; other site
657315005388	oxalacetate/citrate binding site [chemical binding]; other site
657315005389	coenzyme A binding site [chemical binding]; other site
657315005390	catalytic triad [active]
657315005391	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
657315005392	active site
657315005393	catalytic motif [active]
657315005394	Zn binding site [ion binding]; other site
657315005395	Uncharacterized conserved protein [Function unknown]; Region: COG3287
657315005396	FIST N domain; Region: FIST; cl10701
657315005397	FIST C domain; Region: FIST_C; pfam10442
657315005398	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315005399	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315005400	dimer interface [polypeptide binding]; other site
657315005401	putative CheW interface [polypeptide binding]; other site
657315005402	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
657315005403	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
657315005404	active site
657315005405	substrate-binding site [chemical binding]; other site
657315005406	metal-binding site [ion binding]
657315005407	ATP binding site [chemical binding]; other site
657315005408	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
657315005409	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
657315005410	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
657315005411	active site
657315005412	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
657315005413	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
657315005414	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
657315005415	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
657315005416	dimer interface [polypeptide binding]; other site
657315005417	motif 1; other site
657315005418	active site
657315005419	motif 2; other site
657315005420	motif 3; other site
657315005421	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
657315005422	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
657315005423	putative tRNA-binding site [nucleotide binding]; other site
657315005424	B3/4 domain; Region: B3_4; pfam03483
657315005425	tRNA synthetase B5 domain; Region: B5; pfam03484
657315005426	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
657315005427	dimer interface [polypeptide binding]; other site
657315005428	motif 1; other site
657315005429	motif 3; other site
657315005430	motif 2; other site
657315005431	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
657315005432	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
657315005433	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
657315005434	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
657315005435	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
657315005436	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
657315005437	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
657315005438	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
657315005439	prephenate dehydrogenase; Validated; Region: PRK08507
657315005440	prephenate dehydrogenase; Validated; Region: PRK06545
657315005441	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
657315005442	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
657315005443	G1 box; other site
657315005444	GTP/Mg2+ binding site [chemical binding]; other site
657315005445	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
657315005446	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
657315005447	Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947
657315005448	active site
657315005449	catalytic residues [active]
657315005450	metal binding site [ion binding]; metal-binding site
657315005451	Transcriptional regulators [Transcription]; Region: FadR; COG2186
657315005452	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657315005453	DNA-binding site [nucleotide binding]; DNA binding site
657315005454	FCD domain; Region: FCD; pfam07729
657315005455	isocitrate dehydrogenase; Validated; Region: PRK08299
657315005456	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
657315005457	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657315005458	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657315005459	ABC transporter; Region: ABC_tran_2; pfam12848
657315005460	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657315005461	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
657315005462	putative carbohydrate kinase; Provisional; Region: PRK10565
657315005463	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
657315005464	putative substrate binding site [chemical binding]; other site
657315005465	putative ATP binding site [chemical binding]; other site
657315005466	alanine racemase; Reviewed; Region: alr; PRK00053
657315005467	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
657315005468	active site
657315005469	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
657315005470	dimer interface [polypeptide binding]; other site
657315005471	substrate binding site [chemical binding]; other site
657315005472	catalytic residues [active]
657315005473	PemK-like protein; Region: PemK; pfam02452
657315005474	hypothetical protein; Validated; Region: PRK00110
657315005475	glycogen synthase; Provisional; Region: glgA; PRK00654
657315005476	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
657315005477	ADP-binding pocket [chemical binding]; other site
657315005478	homodimer interface [polypeptide binding]; other site
657315005479	Clp protease; Region: CLP_protease; pfam00574
657315005480	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
657315005481	active site
657315005482	Bacitracin resistance protein BacA; Region: BacA; pfam02673
657315005483	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
657315005484	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
657315005485	Potassium binding sites [ion binding]; other site
657315005486	Cesium cation binding sites [ion binding]; other site
657315005487	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
657315005488	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
657315005489	binding surface
657315005490	Tetratricopeptide repeat; Region: TPR_16; pfam13432
657315005491	TPR motif; other site
657315005492	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
657315005493	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
657315005494	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
657315005495	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
657315005496	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
657315005497	inhibitor binding site; inhibition site
657315005498	active site
657315005499	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
657315005500	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
657315005501	Na binding site [ion binding]; other site
657315005502	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
657315005503	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
657315005504	minor groove reading motif; other site
657315005505	helix-hairpin-helix signature motif; other site
657315005506	substrate binding pocket [chemical binding]; other site
657315005507	active site
657315005508	Signal peptide peptidase; Region: Peptidase_A22B; cl01342
657315005509	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
657315005510	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
657315005511	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
657315005512	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
657315005513	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
657315005514	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
657315005515	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
657315005516	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
657315005517	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
657315005518	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
657315005519	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
657315005520	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
657315005521	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
657315005522	YabP family; Region: YabP; cl06766
657315005523	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
657315005524	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
657315005525	PhoH-like protein; Region: PhoH; pfam02562
657315005526	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
657315005527	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
657315005528	metal-binding heat shock protein; Provisional; Region: PRK00016
657315005529	stage V sporulation protein B; Region: spore_V_B; TIGR02900
657315005530	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
657315005531	BofC C-terminal domain; Region: BofC_C; pfam08955
657315005532	flavoprotein, HI0933 family; Region: TIGR00275
657315005533	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
657315005534	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
657315005535	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
657315005536	MutS domain I; Region: MutS_I; pfam01624
657315005537	MutS domain II; Region: MutS_II; pfam05188
657315005538	MutS domain III; Region: MutS_III; pfam05192
657315005539	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
657315005540	Walker A/P-loop; other site
657315005541	ATP binding site [chemical binding]; other site
657315005542	Q-loop/lid; other site
657315005543	ABC transporter signature motif; other site
657315005544	Walker B; other site
657315005545	D-loop; other site
657315005546	H-loop/switch region; other site
657315005547	Thymidylate synthase complementing protein; Region: Thy1; cl03630
657315005548	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
657315005549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315005550	ATP binding site [chemical binding]; other site
657315005551	Mg2+ binding site [ion binding]; other site
657315005552	G-X-G motif; other site
657315005553	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
657315005554	ATP binding site [chemical binding]; other site
657315005555	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
657315005556	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
657315005557	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
657315005558	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
657315005559	Aluminium resistance protein; Region: Alum_res; pfam06838
657315005560	hypothetical protein; Reviewed; Region: PRK00024
657315005561	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
657315005562	MPN+ (JAMM) motif; other site
657315005563	Zinc-binding site [ion binding]; other site
657315005564	rod shape-determining protein MreB; Provisional; Region: PRK13927
657315005565	MreB and similar proteins; Region: MreB_like; cd10225
657315005566	nucleotide binding site [chemical binding]; other site
657315005567	Mg binding site [ion binding]; other site
657315005568	putative protofilament interaction site [polypeptide binding]; other site
657315005569	RodZ interaction site [polypeptide binding]; other site
657315005570	rod shape-determining protein MreC; Provisional; Region: PRK13922
657315005571	rod shape-determining protein MreC; Region: MreC; pfam04085
657315005572	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
657315005573	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
657315005574	Switch II; other site
657315005575	Septum formation topological specificity factor MinE; Region: MinE; cl00538
657315005576	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
657315005577	methylglyoxal synthase; Validated; Region: mgsA; PRK05234
657315005578	substrate binding site [chemical binding]; other site
657315005579	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
657315005580	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
657315005581	Uncharacterized conserved protein [Function unknown]; Region: COG2155
657315005582	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
657315005583	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
657315005584	catalytic residue [active]
657315005585	Protein of unknown function (DUF552); Region: DUF552; pfam04472
657315005586	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
657315005587	active site
657315005588	dimer interface [polypeptide binding]; other site
657315005589	metal binding site [ion binding]; metal-binding site
657315005590	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
657315005591	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
657315005592	lipoprotein signal peptidase; Provisional; Region: PRK14787
657315005593	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
657315005594	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
657315005595	RNA binding surface [nucleotide binding]; other site
657315005596	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
657315005597	active site
657315005598	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
657315005599	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
657315005600	putative active site [active]
657315005601	dimerization interface [polypeptide binding]; other site
657315005602	putative tRNAtyr binding site [nucleotide binding]; other site
657315005603	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
657315005604	Ligand Binding Site [chemical binding]; other site
657315005605	LexA repressor; Validated; Region: PRK00215
657315005606	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
657315005607	putative DNA binding site [nucleotide binding]; other site
657315005608	putative Zn2+ binding site [ion binding]; other site
657315005609	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
657315005610	Catalytic site [active]
657315005611	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315005612	Zn2+ binding site [ion binding]; other site
657315005613	Mg2+ binding site [ion binding]; other site
657315005614	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
657315005615	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
657315005616	active site
657315005617	(T/H)XGH motif; other site
657315005618	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
657315005619	GTPase CgtA; Reviewed; Region: obgE; PRK12297
657315005620	GTP1/OBG; Region: GTP1_OBG; pfam01018
657315005621	Obg GTPase; Region: Obg; cd01898
657315005622	G1 box; other site
657315005623	GTP/Mg2+ binding site [chemical binding]; other site
657315005624	Switch I region; other site
657315005625	G2 box; other site
657315005626	G3 box; other site
657315005627	Switch II region; other site
657315005628	G4 box; other site
657315005629	G5 box; other site
657315005630	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
657315005631	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
657315005632	Protein of unknown function (DUF464); Region: DUF464; pfam04327
657315005633	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
657315005634	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
657315005635	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
657315005636	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
657315005637	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
657315005638	homodimer interface [polypeptide binding]; other site
657315005639	oligonucleotide binding site [chemical binding]; other site
657315005640	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
657315005641	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
657315005642	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
657315005643	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315005644	FeS/SAM binding site; other site
657315005645	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
657315005646	Acyltransferase family; Region: Acyl_transf_3; pfam01757
657315005647	Divergent AAA domain; Region: AAA_4; pfam04326
657315005648	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
657315005649	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
657315005650	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
657315005651	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
657315005652	metal binding site [ion binding]; metal-binding site
657315005653	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
657315005654	putative active site pocket [active]
657315005655	4-fold oligomerization interface [polypeptide binding]; other site
657315005656	metal binding residues [ion binding]; metal-binding site
657315005657	3-fold/trimer interface [polypeptide binding]; other site
657315005658	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
657315005659	histidinol dehydrogenase; Region: hisD; TIGR00069
657315005660	NAD binding site [chemical binding]; other site
657315005661	dimerization interface [polypeptide binding]; other site
657315005662	product binding site; other site
657315005663	substrate binding site [chemical binding]; other site
657315005664	zinc binding site [ion binding]; other site
657315005665	catalytic residues [active]
657315005666	ATP phosphoribosyltransferase; Region: HisG; cl15266
657315005667	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
657315005668	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
657315005669	dimer interface [polypeptide binding]; other site
657315005670	motif 1; other site
657315005671	active site
657315005672	motif 2; other site
657315005673	motif 3; other site
657315005674	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
657315005675	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
657315005676	hypothetical protein; Provisional; Region: PRK00955
657315005677	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
657315005678	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
657315005679	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
657315005680	RNA binding surface [nucleotide binding]; other site
657315005681	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
657315005682	active site
657315005683	uracil binding [chemical binding]; other site
657315005684	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
657315005685	Peptidase family M23; Region: Peptidase_M23; pfam01551
657315005686	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
657315005687	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
657315005688	metal binding site [ion binding]; metal-binding site
657315005689	dimer interface [polypeptide binding]; other site
657315005690	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
657315005691	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
657315005692	active site
657315005693	(T/H)XGH motif; other site
657315005694	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
657315005695	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315005696	S-adenosylmethionine binding site [chemical binding]; other site
657315005697	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
657315005698	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
657315005699	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
657315005700	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315005701	FeS/SAM binding site; other site
657315005702	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
657315005703	Domain of unknown function (DUF370); Region: DUF370; cl00898
657315005704	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315005705	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315005706	non-specific DNA binding site [nucleotide binding]; other site
657315005707	salt bridge; other site
657315005708	sequence-specific DNA binding site [nucleotide binding]; other site
657315005709	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
657315005710	HTH domain; Region: HTH_11; pfam08279
657315005711	3H domain; Region: 3H; pfam02829
657315005712	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
657315005713	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
657315005714	dimerization interface [polypeptide binding]; other site
657315005715	active site
657315005716	L-aspartate oxidase; Provisional; Region: PRK06175
657315005717	FAD binding domain; Region: FAD_binding_2; pfam00890
657315005718	Quinolinate synthetase A protein; Region: NadA; pfam02445
657315005719	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
657315005720	oligoendopeptidase F; Region: pepF; TIGR00181
657315005721	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
657315005722	active site
657315005723	Zn binding site [ion binding]; other site
657315005724	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
657315005725	Switch I region; other site
657315005726	G3 box; other site
657315005727	Switch II region; other site
657315005728	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
657315005729	Domain of unknown function (DUF814); Region: DUF814; pfam05670
657315005730	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
657315005731	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
657315005732	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
657315005733	Y-family of DNA polymerases; Region: PolY; cl12025
657315005734	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
657315005735	ssDNA binding site; other site
657315005736	generic binding surface II; other site
657315005737	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
657315005738	ATP binding site [chemical binding]; other site
657315005739	putative Mg++ binding site [ion binding]; other site
657315005740	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
657315005741	nucleotide binding region [chemical binding]; other site
657315005742	ATP-binding site [chemical binding]; other site
657315005743	Asp23 family; Region: Asp23; pfam03780
657315005744	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
657315005745	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
657315005746	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
657315005747	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
657315005748	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
657315005749	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
657315005750	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
657315005751	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
657315005752	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
657315005753	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
657315005754	inhibitor binding site; inhibition site
657315005755	active site
657315005756	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
657315005757	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
657315005758	active site
657315005759	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
657315005760	active site
657315005761	catalytic triad [active]
657315005762	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315005763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315005764	conserved gate region; other site
657315005765	ABC-ATPase subunit interface; other site
657315005766	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
657315005767	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315005768	dimer interface [polypeptide binding]; other site
657315005769	conserved gate region; other site
657315005770	putative PBP binding loops; other site
657315005771	ABC-ATPase subunit interface; other site
657315005772	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315005773	Beta-lactamase; Region: Beta-lactamase; pfam00144
657315005774	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
657315005775	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
657315005776	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
657315005777	NADP binding site [chemical binding]; other site
657315005778	homodimer interface [polypeptide binding]; other site
657315005779	active site
657315005780	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
657315005781	galactarate dehydratase; Region: galactar-dH20; TIGR03248
657315005782	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
657315005783	altronate oxidoreductase; Provisional; Region: PRK03643
657315005784	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
657315005785	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
657315005786	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315005787	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657315005788	DNA binding site [nucleotide binding]
657315005789	domain linker motif; other site
657315005790	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657315005791	dimerization interface [polypeptide binding]; other site
657315005792	ligand binding site [chemical binding]; other site
657315005793	Glucuronate isomerase; Region: UxaC; pfam02614
657315005794	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
657315005795	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
657315005796	hypothetical protein; Provisional; Region: PRK09273
657315005797	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
657315005798	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
657315005799	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; pfam09579
657315005800	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
657315005801	active site
657315005802	Ap6A binding site [chemical binding]; other site
657315005803	nudix motif; other site
657315005804	metal binding site [ion binding]; metal-binding site
657315005805	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
657315005806	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
657315005807	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
657315005808	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
657315005809	Peptidase family U32; Region: Peptidase_U32; pfam01136
657315005810	Collagenase; Region: DUF3656; pfam12392
657315005811	Peptidase family U32; Region: Peptidase_U32; cl03113
657315005812	Cell division protein ZapA; Region: ZapA; pfam05164
657315005813	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
657315005814	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315005815	Walker A motif; other site
657315005816	ATP binding site [chemical binding]; other site
657315005817	Walker B motif; other site
657315005818	arginine finger; other site
657315005819	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
657315005820	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
657315005821	RuvA N terminal domain; Region: RuvA_N; pfam01330
657315005822	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
657315005823	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
657315005824	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
657315005825	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315005826	FeS/SAM binding site; other site
657315005827	TRAM domain; Region: TRAM; pfam01938
657315005828	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
657315005829	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
657315005830	putative catalytic cysteine [active]
657315005831	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
657315005832	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
657315005833	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
657315005834	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
657315005835	ApbE family; Region: ApbE; pfam02424
657315005836	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
657315005837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315005838	dimer interface [polypeptide binding]; other site
657315005839	conserved gate region; other site
657315005840	putative PBP binding loops; other site
657315005841	ABC-ATPase subunit interface; other site
657315005842	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315005843	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657315005844	1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336
657315005845	Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508
657315005846	Cupin domain; Region: Cupin_2; pfam07883
657315005847	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315005848	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
657315005849	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
657315005850	substrate binding site [chemical binding]; other site
657315005851	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
657315005852	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
657315005853	substrate binding site [chemical binding]; other site
657315005854	ligand binding site [chemical binding]; other site
657315005855	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657315005856	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657315005857	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657315005858	dimerization interface [polypeptide binding]; other site
657315005859	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315005860	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657315005861	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
657315005862	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
657315005863	HIGH motif; other site
657315005864	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
657315005865	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657315005866	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657315005867	active site
657315005868	KMSKS motif; other site
657315005869	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
657315005870	tRNA binding surface [nucleotide binding]; other site
657315005871	ketol-acid reductoisomerase; Provisional; Region: PRK05479
657315005872	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
657315005873	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
657315005874	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
657315005875	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
657315005876	putative valine binding site [chemical binding]; other site
657315005877	dimer interface [polypeptide binding]; other site
657315005878	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
657315005879	Predicted membrane protein [Function unknown]; Region: COG1511
657315005880	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
657315005881	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
657315005882	Predicted membrane protein [Function unknown]; Region: COG1511
657315005883	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
657315005884	Allexivirus 40kDa protein; Region: Allexi_40kDa; pfam05549
657315005885	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
657315005886	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
657315005887	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
657315005888	active site
657315005889	DNA binding site [nucleotide binding]
657315005890	GGGtGRT protein; Region: GGGtGRT; pfam14057
657315005891	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
657315005892	YARHG domain; Region: YARHG; pfam13308
657315005893	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315005894	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315005895	dimer interface [polypeptide binding]; other site
657315005896	putative CheW interface [polypeptide binding]; other site
657315005897	Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636
657315005898	Archaeal ATPase; Region: Arch_ATPase; pfam01637
657315005899	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
657315005900	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
657315005901	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
657315005902	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
657315005903	argininosuccinate lyase; Provisional; Region: PRK00855
657315005904	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
657315005905	active sites [active]
657315005906	tetramer interface [polypeptide binding]; other site
657315005907	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
657315005908	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315005909	Zn2+ binding site [ion binding]; other site
657315005910	Mg2+ binding site [ion binding]; other site
657315005911	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
657315005912	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
657315005913	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
657315005914	catalytic core [active]
657315005915	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
657315005916	cobalamin synthase; Reviewed; Region: cobS; PRK00235
657315005917	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657315005918	Walker A motif; other site
657315005919	ATP binding site [chemical binding]; other site
657315005920	Walker B motif; other site
657315005921	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
657315005922	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
657315005923	putative dimer interface [polypeptide binding]; other site
657315005924	active site pocket [active]
657315005925	putative cataytic base [active]
657315005926	cobyric acid synthase; Provisional; Region: PRK00784
657315005927	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
657315005928	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
657315005929	catalytic triad [active]
657315005930	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315005931	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
657315005932	HAMP domain; Region: HAMP; pfam00672
657315005933	dimerization interface [polypeptide binding]; other site
657315005934	Histidine kinase; Region: His_kinase; pfam06580
657315005935	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315005936	ATP binding site [chemical binding]; other site
657315005937	Mg2+ binding site [ion binding]; other site
657315005938	G-X-G motif; other site
657315005939	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
657315005940	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
657315005941	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
657315005942	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
657315005943	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
657315005944	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
657315005945	Protein of unknown function, DUF624; Region: DUF624; pfam04854
657315005946	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315005947	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657315005948	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315005949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315005950	dimer interface [polypeptide binding]; other site
657315005951	conserved gate region; other site
657315005952	putative PBP binding loops; other site
657315005953	ABC-ATPase subunit interface; other site
657315005954	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
657315005955	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
657315005956	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
657315005957	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
657315005958	catalytic loop [active]
657315005959	iron binding site [ion binding]; other site
657315005960	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
657315005961	active site
657315005962	DNA binding site [nucleotide binding]
657315005963	putative catalytic site [active]
657315005964	putative phosphate binding site [ion binding]; other site
657315005965	metal binding site A [ion binding]; metal-binding site
657315005966	AP binding site [nucleotide binding]; other site
657315005967	metal binding site B [ion binding]; metal-binding site
657315005968	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
657315005969	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657315005970	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315005971	homodimer interface [polypeptide binding]; other site
657315005972	catalytic residue [active]
657315005973	Septum formation topological specificity factor MinE; Region: MinE; cl00538
657315005974	septum site-determining protein MinD; Region: minD_bact; TIGR01968
657315005975	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
657315005976	Switch I; other site
657315005977	Switch II; other site
657315005978	septum formation inhibitor; Reviewed; Region: minC; PRK00513
657315005979	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
657315005980	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
657315005981	thiamine phosphate binding site [chemical binding]; other site
657315005982	active site
657315005983	pyrophosphate binding site [ion binding]; other site
657315005984	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
657315005985	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
657315005986	thiazole synthase; Reviewed; Region: thiG; PRK00208
657315005987	phosphate binding site [ion binding]; other site
657315005988	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
657315005989	thiS-thiF/thiG interaction site; other site
657315005990	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
657315005991	active site
657315005992	catalytic triad [active]
657315005993	oxyanion hole [active]
657315005994	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
657315005995	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
657315005996	ATP-binding site [chemical binding]; other site
657315005997	Sugar specificity; other site
657315005998	Pyrimidine base specificity; other site
657315005999	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
657315006000	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315006001	non-specific DNA binding site [nucleotide binding]; other site
657315006002	salt bridge; other site
657315006003	sequence-specific DNA binding site [nucleotide binding]; other site
657315006004	Cupin domain; Region: Cupin_2; pfam07883
657315006005	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
657315006006	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315006007	Walker A/P-loop; other site
657315006008	ATP binding site [chemical binding]; other site
657315006009	Q-loop/lid; other site
657315006010	ABC transporter signature motif; other site
657315006011	Walker B; other site
657315006012	D-loop; other site
657315006013	H-loop/switch region; other site
657315006014	TOBE domain; Region: TOBE_2; pfam08402
657315006015	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315006016	dimer interface [polypeptide binding]; other site
657315006017	conserved gate region; other site
657315006018	putative PBP binding loops; other site
657315006019	ABC-ATPase subunit interface; other site
657315006020	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
657315006021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315006022	dimer interface [polypeptide binding]; other site
657315006023	conserved gate region; other site
657315006024	putative PBP binding loops; other site
657315006025	ABC-ATPase subunit interface; other site
657315006026	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
657315006027	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
657315006028	glycogen synthase; Provisional; Region: glgA; PRK00654
657315006029	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
657315006030	ADP-binding pocket [chemical binding]; other site
657315006031	homodimer interface [polypeptide binding]; other site
657315006032	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
657315006033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315006034	active site
657315006035	phosphorylation site [posttranslational modification]
657315006036	intermolecular recognition site; other site
657315006037	dimerization interface [polypeptide binding]; other site
657315006038	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
657315006039	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
657315006040	binding surface
657315006041	TPR motif; other site
657315006042	Tetratricopeptide repeat; Region: TPR_12; pfam13424
657315006043	Tetratricopeptide repeat; Region: TPR_12; pfam13424
657315006044	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315006045	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315006046	metal binding site [ion binding]; metal-binding site
657315006047	active site
657315006048	I-site; other site
657315006049	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
657315006050	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
657315006051	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
657315006052	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
657315006053	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
657315006054	Walker A/P-loop; other site
657315006055	ATP binding site [chemical binding]; other site
657315006056	Q-loop/lid; other site
657315006057	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
657315006058	ABC transporter signature motif; other site
657315006059	Walker B; other site
657315006060	D-loop; other site
657315006061	H-loop/switch region; other site
657315006062	arginine repressor; Provisional; Region: argR; PRK00441
657315006063	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
657315006064	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
657315006065	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
657315006066	ATP-NAD kinase; Region: NAD_kinase; pfam01513
657315006067	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
657315006068	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
657315006069	TPP-binding site; other site
657315006070	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
657315006071	PYR/PP interface [polypeptide binding]; other site
657315006072	dimer interface [polypeptide binding]; other site
657315006073	TPP binding site [chemical binding]; other site
657315006074	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
657315006075	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
657315006076	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
657315006077	substrate binding pocket [chemical binding]; other site
657315006078	chain length determination region; other site
657315006079	substrate-Mg2+ binding site; other site
657315006080	catalytic residues [active]
657315006081	aspartate-rich region 1; other site
657315006082	active site lid residues [active]
657315006083	aspartate-rich region 2; other site
657315006084	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
657315006085	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
657315006086	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
657315006087	generic binding surface II; other site
657315006088	generic binding surface I; other site
657315006089	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
657315006090	putative RNA binding site [nucleotide binding]; other site
657315006091	Asp23 family; Region: Asp23; pfam03780
657315006092	Homoserine O-succinyltransferase; Region: HTS; pfam04204
657315006093	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
657315006094	proposed active site lysine [active]
657315006095	conserved cys residue [active]
657315006096	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
657315006097	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
657315006098	nucleotide binding pocket [chemical binding]; other site
657315006099	K-X-D-G motif; other site
657315006100	catalytic site [active]
657315006101	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
657315006102	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
657315006103	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
657315006104	Dimer interface [polypeptide binding]; other site
657315006105	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
657315006106	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
657315006107	RNA binding surface [nucleotide binding]; other site
657315006108	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
657315006109	probable active site [active]
657315006110	Bacterial SH3 domain; Region: SH3_3; pfam08239
657315006111	Bacterial SH3 domain; Region: SH3_3; pfam08239
657315006112	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
657315006113	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
657315006114	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
657315006115	NAD binding site [chemical binding]; other site
657315006116	dimer interface [polypeptide binding]; other site
657315006117	substrate binding site [chemical binding]; other site
657315006118	tetramer (dimer of dimers) interface [polypeptide binding]; other site
657315006119	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315006120	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315006121	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
657315006122	Walker A/P-loop; other site
657315006123	ATP binding site [chemical binding]; other site
657315006124	Q-loop/lid; other site
657315006125	ABC transporter signature motif; other site
657315006126	Walker B; other site
657315006127	D-loop; other site
657315006128	H-loop/switch region; other site
657315006129	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315006130	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315006131	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315006132	Walker A/P-loop; other site
657315006133	ATP binding site [chemical binding]; other site
657315006134	Q-loop/lid; other site
657315006135	ABC transporter signature motif; other site
657315006136	Walker B; other site
657315006137	D-loop; other site
657315006138	H-loop/switch region; other site
657315006139	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
657315006140	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
657315006141	putative Zn2+ binding site [ion binding]; other site
657315006142	putative DNA binding site [nucleotide binding]; other site
657315006143	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
657315006144	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
657315006145	active site
657315006146	catalytic residue [active]
657315006147	dimer interface [polypeptide binding]; other site
657315006148	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
657315006149	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
657315006150	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315006151	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
657315006152	active site
657315006153	DNA binding site [nucleotide binding]
657315006154	Int/Topo IB signature motif; other site
657315006155	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
657315006156	dimer interface [polypeptide binding]; other site
657315006157	ADP-ribose binding site [chemical binding]; other site
657315006158	active site
657315006159	nudix motif; other site
657315006160	metal binding site [ion binding]; metal-binding site
657315006161	Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137
657315006162	recombinase A; Provisional; Region: recA; PRK09354
657315006163	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
657315006164	hexamer interface [polypeptide binding]; other site
657315006165	Walker A motif; other site
657315006166	ATP binding site [chemical binding]; other site
657315006167	Walker B motif; other site
657315006168	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
657315006169	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
657315006170	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
657315006171	catalytic residues [active]
657315006172	phosphopentomutase; Provisional; Region: PRK05362
657315006173	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
657315006174	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657315006175	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657315006176	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657315006177	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657315006178	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315006179	non-specific DNA binding site [nucleotide binding]; other site
657315006180	salt bridge; other site
657315006181	sequence-specific DNA binding site [nucleotide binding]; other site
657315006182	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
657315006183	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
657315006184	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
657315006185	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
657315006186	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
657315006187	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
657315006188	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
657315006189	Carbon starvation protein CstA; Region: CstA; pfam02554
657315006190	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
657315006191	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
657315006192	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
657315006193	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657315006194	active site
657315006195	HIGH motif; other site
657315006196	nucleotide binding site [chemical binding]; other site
657315006197	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
657315006198	KMSK motif region; other site
657315006199	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
657315006200	tRNA binding surface [nucleotide binding]; other site
657315006201	anticodon binding site; other site
657315006202	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
657315006203	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
657315006204	nucleotide binding site [chemical binding]; other site
657315006205	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
657315006206	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
657315006207	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
657315006208	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
657315006209	fructuronate transporter; Provisional; Region: PRK10034; cl15264
657315006210	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
657315006211	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
657315006212	putative active site cavity [active]
657315006213	QueT transporter; Region: QueT; pfam06177
657315006214	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
657315006215	Catalytic site [active]
657315006216	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
657315006217	putative glycosyl transferase; Provisional; Region: PRK10073
657315006218	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
657315006219	active site
657315006220	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
657315006221	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657315006222	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
657315006223	active site
657315006224	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657315006225	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
657315006226	Ligand binding site; other site
657315006227	Putative Catalytic site; other site
657315006228	DXD motif; other site
657315006229	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
657315006230	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
657315006231	putative ADP-binding pocket [chemical binding]; other site
657315006232	Predicted membrane protein [Function unknown]; Region: COG4267
657315006233	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
657315006234	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
657315006235	Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960
657315006236	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
657315006237	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
657315006238	NAD(P) binding site [chemical binding]; other site
657315006239	active site
657315006240	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
657315006241	GAF domain; Region: GAF_3; pfam13492
657315006242	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
657315006243	diaminopimelate epimerase; Provisional; Region: PRK13577
657315006244	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
657315006245	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
657315006246	sporulation sigma factor SigG; Reviewed; Region: PRK08215
657315006247	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657315006248	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
657315006249	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657315006250	DNA binding residues [nucleotide binding]
657315006251	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
657315006252	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
657315006253	Beta-Casp domain; Region: Beta-Casp; smart01027
657315006254	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
657315006255	sporulation sigma factor SigE; Reviewed; Region: PRK08301
657315006256	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657315006257	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657315006258	DNA binding residues [nucleotide binding]
657315006259	cell division protein FtsW; Region: ftsW; TIGR02614
657315006260	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
657315006261	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
657315006262	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
657315006263	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
657315006264	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
657315006265	Mg++ binding site [ion binding]; other site
657315006266	putative catalytic motif [active]
657315006267	putative substrate binding site [chemical binding]; other site
657315006268	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
657315006269	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
657315006270	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
657315006271	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
657315006272	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
657315006273	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
657315006274	Septum formation initiator; Region: DivIC; cl17659
657315006275	CHD5-like protein; Region: CHD5; pfam04420
657315006276	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
657315006277	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
657315006278	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
657315006279	hypothetical protein; Provisional; Region: PRK05590
657315006280	SEC-C motif; Region: SEC-C; pfam02810
657315006281	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
657315006282	dimer interface [polypeptide binding]; other site
657315006283	Citrate synthase; Region: Citrate_synt; pfam00285
657315006284	active site
657315006285	citrylCoA binding site [chemical binding]; other site
657315006286	oxalacetate/citrate binding site [chemical binding]; other site
657315006287	coenzyme A binding site [chemical binding]; other site
657315006288	catalytic triad [active]
657315006289	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
657315006290	MarR family; Region: MarR_2; pfam12802
657315006291	MarR family; Region: MarR_2; cl17246
657315006292	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
657315006293	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
657315006294	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
657315006295	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
657315006296	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
657315006297	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315006298	motif II; other site
657315006299	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
657315006300	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
657315006301	GDP-binding site [chemical binding]; other site
657315006302	ACT binding site; other site
657315006303	IMP binding site; other site
657315006304	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657315006305	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657315006306	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657315006307	dimerization interface [polypeptide binding]; other site
657315006308	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315006309	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657315006310	EDD domain protein, DegV family; Region: DegV; TIGR00762
657315006311	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
657315006312	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
657315006313	active site
657315006314	dimer interfaces [polypeptide binding]; other site
657315006315	catalytic residues [active]
657315006316	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
657315006317	nudix motif; other site
657315006318	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315006319	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315006320	dimer interface [polypeptide binding]; other site
657315006321	putative CheW interface [polypeptide binding]; other site
657315006322	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
657315006323	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315006324	salt bridge; other site
657315006325	non-specific DNA binding site [nucleotide binding]; other site
657315006326	sequence-specific DNA binding site [nucleotide binding]; other site
657315006327	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
657315006328	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
657315006329	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
657315006330	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
657315006331	Predicted transcriptional regulators [Transcription]; Region: COG1725
657315006332	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657315006333	DNA-binding site [nucleotide binding]; DNA binding site
657315006334	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
657315006335	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
657315006336	Walker A/P-loop; other site
657315006337	ATP binding site [chemical binding]; other site
657315006338	Q-loop/lid; other site
657315006339	ABC transporter signature motif; other site
657315006340	Walker B; other site
657315006341	D-loop; other site
657315006342	H-loop/switch region; other site
657315006343	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
657315006344	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
657315006345	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315006346	motif II; other site
657315006347	putative oxidoreductase; Provisional; Region: PRK12831
657315006348	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657315006349	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
657315006350	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
657315006351	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
657315006352	FAD binding pocket [chemical binding]; other site
657315006353	FAD binding motif [chemical binding]; other site
657315006354	phosphate binding motif [ion binding]; other site
657315006355	beta-alpha-beta structure motif; other site
657315006356	NAD binding pocket [chemical binding]; other site
657315006357	Iron coordination center [ion binding]; other site
657315006358	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
657315006359	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315006360	Walker A/P-loop; other site
657315006361	ATP binding site [chemical binding]; other site
657315006362	Q-loop/lid; other site
657315006363	ABC transporter signature motif; other site
657315006364	Walker B; other site
657315006365	D-loop; other site
657315006366	H-loop/switch region; other site
657315006367	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
657315006368	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
657315006369	TM-ABC transporter signature motif; other site
657315006370	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
657315006371	zinc binding site [ion binding]; other site
657315006372	putative ligand binding site [chemical binding]; other site
657315006373	Hemerythrin; Region: Hemerythrin; cd12107
657315006374	Fe binding site [ion binding]; other site
657315006375	Hemerythrin; Region: Hemerythrin; cd12107
657315006376	Fe binding site [ion binding]; other site
657315006377	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657315006378	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
657315006379	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
657315006380	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
657315006381	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
657315006382	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315006383	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315006384	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
657315006385	Walker A/P-loop; other site
657315006386	ATP binding site [chemical binding]; other site
657315006387	Q-loop/lid; other site
657315006388	ABC transporter signature motif; other site
657315006389	Walker B; other site
657315006390	D-loop; other site
657315006391	H-loop/switch region; other site
657315006392	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
657315006393	PilZ domain; Region: PilZ; pfam07238
657315006394	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
657315006395	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315006396	dimerization interface [polypeptide binding]; other site
657315006397	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315006398	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315006399	dimer interface [polypeptide binding]; other site
657315006400	putative CheW interface [polypeptide binding]; other site
657315006401	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
657315006402	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
657315006403	active site
657315006404	putative substrate binding pocket [chemical binding]; other site
657315006405	purine nucleoside phosphorylase; Provisional; Region: PRK08202
657315006406	Predicted membrane protein [Function unknown]; Region: COG2364
657315006407	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
657315006408	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
657315006409	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
657315006410	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
657315006411	4-alpha-glucanotransferase; Provisional; Region: PRK14508
657315006412	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315006413	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657315006414	DNA binding site [nucleotide binding]
657315006415	domain linker motif; other site
657315006416	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657315006417	ligand binding site [chemical binding]; other site
657315006418	dimerization interface [polypeptide binding]; other site
657315006419	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315006420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315006421	dimer interface [polypeptide binding]; other site
657315006422	conserved gate region; other site
657315006423	putative PBP binding loops; other site
657315006424	ABC-ATPase subunit interface; other site
657315006425	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
657315006426	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
657315006427	Cl- selectivity filter; other site
657315006428	Cl- binding residues [ion binding]; other site
657315006429	pore gating glutamate residue; other site
657315006430	dimer interface [polypeptide binding]; other site
657315006431	Protein of unknown function (DUF1284); Region: DUF1284; cl01419
657315006432	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
657315006433	BioY family; Region: BioY; pfam02632
657315006434	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
657315006435	active site
657315006436	homodimer interface [polypeptide binding]; other site
657315006437	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
657315006438	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
657315006439	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657315006440	catalytic residue [active]
657315006441	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
657315006442	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
657315006443	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
657315006444	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
657315006445	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
657315006446	substrate binding site [chemical binding]; other site
657315006447	active site
657315006448	catalytic residues [active]
657315006449	heterodimer interface [polypeptide binding]; other site
657315006450	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
657315006451	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657315006452	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
657315006453	catalytic residue [active]
657315006454	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
657315006455	active site
657315006456	ribulose/triose binding site [chemical binding]; other site
657315006457	phosphate binding site [ion binding]; other site
657315006458	substrate (anthranilate) binding pocket [chemical binding]; other site
657315006459	product (indole) binding pocket [chemical binding]; other site
657315006460	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
657315006461	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
657315006462	glutamine binding [chemical binding]; other site
657315006463	catalytic triad [active]
657315006464	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
657315006465	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
657315006466	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657315006467	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
657315006468	Melibiase; Region: Melibiase; pfam02065
657315006469	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
657315006470	MFS/sugar transport protein; Region: MFS_2; pfam13347
657315006471	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
657315006472	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
657315006473	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
657315006474	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
657315006475	AIR carboxylase; Region: AIRC; smart01001
657315006476	Protein of unknown function DUF111; Region: DUF111; cl03398
657315006477	Protein of unknown function DUF111; Region: DUF111; pfam01969
657315006478	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
657315006479	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657315006480	Coenzyme A binding pocket [chemical binding]; other site
657315006481	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
657315006482	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
657315006483	Na binding site [ion binding]; other site
657315006484	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
657315006485	dimer interface [polypeptide binding]; other site
657315006486	substrate binding site [chemical binding]; other site
657315006487	ATP binding site [chemical binding]; other site
657315006488	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315006489	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315006490	dimerization interface [polypeptide binding]; other site
657315006491	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315006492	dimer interface [polypeptide binding]; other site
657315006493	phosphorylation site [posttranslational modification]
657315006494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315006495	ATP binding site [chemical binding]; other site
657315006496	Mg2+ binding site [ion binding]; other site
657315006497	G-X-G motif; other site
657315006498	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315006499	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315006500	active site
657315006501	phosphorylation site [posttranslational modification]
657315006502	intermolecular recognition site; other site
657315006503	dimerization interface [polypeptide binding]; other site
657315006504	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315006505	DNA binding site [nucleotide binding]
657315006506	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
657315006507	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
657315006508	catalytic residues [active]
657315006509	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
657315006510	FAD binding site [chemical binding]; other site
657315006511	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
657315006512	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
657315006513	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
657315006514	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
657315006515	putative binding surface; other site
657315006516	active site
657315006517	Response regulator receiver domain; Region: Response_reg; pfam00072
657315006518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315006519	active site
657315006520	phosphorylation site [posttranslational modification]
657315006521	intermolecular recognition site; other site
657315006522	dimerization interface [polypeptide binding]; other site
657315006523	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315006524	metal binding site [ion binding]; metal-binding site
657315006525	active site
657315006526	I-site; other site
657315006527	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
657315006528	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
657315006529	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
657315006530	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
657315006531	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
657315006532	putative alpha-glucosidase; Provisional; Region: PRK10658
657315006533	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
657315006534	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
657315006535	active site
657315006536	homotrimer interface [polypeptide binding]; other site
657315006537	catalytic site [active]
657315006538	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
657315006539	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
657315006540	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315006541	active site
657315006542	phosphorylation site [posttranslational modification]
657315006543	intermolecular recognition site; other site
657315006544	dimerization interface [polypeptide binding]; other site
657315006545	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315006546	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315006547	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315006548	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
657315006549	Walker A/P-loop; other site
657315006550	ATP binding site [chemical binding]; other site
657315006551	Q-loop/lid; other site
657315006552	ABC transporter signature motif; other site
657315006553	Walker B; other site
657315006554	D-loop; other site
657315006555	H-loop/switch region; other site
657315006556	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315006557	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315006558	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
657315006559	Walker A/P-loop; other site
657315006560	ATP binding site [chemical binding]; other site
657315006561	Q-loop/lid; other site
657315006562	ABC transporter signature motif; other site
657315006563	Walker B; other site
657315006564	D-loop; other site
657315006565	H-loop/switch region; other site
657315006566	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657315006567	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315006568	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315006569	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315006570	AAA domain; Region: AAA_14; pfam13173
657315006571	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
657315006572	Domain of unknown function, E. rectale Gene description (DUF3879); Region: DUF3879; pfam12995
657315006573	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
657315006574	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315006575	ATP binding site [chemical binding]; other site
657315006576	Mg2+ binding site [ion binding]; other site
657315006577	G-X-G motif; other site
657315006578	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657315006579	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315006580	active site
657315006581	phosphorylation site [posttranslational modification]
657315006582	intermolecular recognition site; other site
657315006583	dimerization interface [polypeptide binding]; other site
657315006584	LytTr DNA-binding domain; Region: LytTR; smart00850
657315006585	hypothetical protein; Validated; Region: PRK07668
657315006586	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
657315006587	ATP binding site [chemical binding]; other site
657315006588	Mg2+ binding site [ion binding]; other site
657315006589	G-X-G motif; other site
657315006590	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315006591	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
657315006592	putative catalytic residues [active]
657315006593	catalytic nucleophile [active]
657315006594	Recombinase; Region: Recombinase; pfam07508
657315006595	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315006596	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
657315006597	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657315006598	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657315006599	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
657315006600	catalytic tetrad [active]
657315006601	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315006602	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315006603	metal binding site [ion binding]; metal-binding site
657315006604	active site
657315006605	I-site; other site
657315006606	Uncharacterized conserved protein [Function unknown]; Region: COG1284
657315006607	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
657315006608	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
657315006609	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
657315006610	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315006611	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657315006612	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
657315006613	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315006614	Walker A/P-loop; other site
657315006615	ATP binding site [chemical binding]; other site
657315006616	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
657315006617	hypothetical protein; Provisional; Region: PRK09609
657315006618	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
657315006619	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315006620	S-adenosylmethionine binding site [chemical binding]; other site
657315006621	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
657315006622	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
657315006623	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
657315006624	G1 box; other site
657315006625	putative GEF interaction site [polypeptide binding]; other site
657315006626	GTP/Mg2+ binding site [chemical binding]; other site
657315006627	Switch I region; other site
657315006628	G2 box; other site
657315006629	G3 box; other site
657315006630	Switch II region; other site
657315006631	G4 box; other site
657315006632	G5 box; other site
657315006633	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
657315006634	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
657315006635	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
657315006636	YacP-like NYN domain; Region: NYN_YacP; pfam05991
657315006637	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
657315006638	MgtE intracellular N domain; Region: MgtE_N; pfam03448
657315006639	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
657315006640	Divalent cation transporter; Region: MgtE; pfam01769
657315006641	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315006642	Walker A/P-loop; other site
657315006643	ATP binding site [chemical binding]; other site
657315006644	Q-loop/lid; other site
657315006645	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315006646	ABC transporter signature motif; other site
657315006647	Walker B; other site
657315006648	D-loop; other site
657315006649	H-loop/switch region; other site
657315006650	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315006651	AAA domain; Region: AAA_21; pfam13304
657315006652	Walker A/P-loop; other site
657315006653	ATP binding site [chemical binding]; other site
657315006654	Q-loop/lid; other site
657315006655	ABC transporter signature motif; other site
657315006656	Walker B; other site
657315006657	D-loop; other site
657315006658	H-loop/switch region; other site
657315006659	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
657315006660	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
657315006661	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
657315006662	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
657315006663	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
657315006664	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
657315006665	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
657315006666	active site
657315006667	MoxR-like ATPases [General function prediction only]; Region: COG0714
657315006668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315006669	Walker A motif; other site
657315006670	ATP binding site [chemical binding]; other site
657315006671	Walker B motif; other site
657315006672	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
657315006673	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
657315006674	metal ion-dependent adhesion site (MIDAS); other site
657315006675	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657315006676	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
657315006677	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657315006678	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
657315006679	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
657315006680	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
657315006681	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
657315006682	active site
657315006683	Zn binding site [ion binding]; other site
657315006684	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
657315006685	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657315006686	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315006687	dimerization interface [polypeptide binding]; other site
657315006688	ligand binding site [chemical binding]; other site
657315006689	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315006690	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315006691	metal binding site [ion binding]; metal-binding site
657315006692	active site
657315006693	I-site; other site
657315006694	elongation factor P; Validated; Region: PRK00529
657315006695	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
657315006696	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
657315006697	RNA binding site [nucleotide binding]; other site
657315006698	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
657315006699	RNA binding site [nucleotide binding]; other site
657315006700	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
657315006701	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
657315006702	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315006703	active site
657315006704	motif I; other site
657315006705	motif II; other site
657315006706	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
657315006707	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
657315006708	ATP cone domain; Region: ATP-cone; pfam03477
657315006709	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
657315006710	GTP-binding protein YchF; Reviewed; Region: PRK09601
657315006711	YchF GTPase; Region: YchF; cd01900
657315006712	G1 box; other site
657315006713	GTP/Mg2+ binding site [chemical binding]; other site
657315006714	Switch I region; other site
657315006715	G2 box; other site
657315006716	Switch II region; other site
657315006717	G3 box; other site
657315006718	G4 box; other site
657315006719	G5 box; other site
657315006720	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
657315006721	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315006722	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
657315006723	Thiamine pyrophosphokinase; Region: TPK; cd07995
657315006724	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
657315006725	active site
657315006726	dimerization interface [polypeptide binding]; other site
657315006727	thiamine binding site [chemical binding]; other site
657315006728	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
657315006729	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
657315006730	substrate binding site [chemical binding]; other site
657315006731	hexamer interface [polypeptide binding]; other site
657315006732	metal binding site [ion binding]; metal-binding site
657315006733	GTPase RsgA; Reviewed; Region: PRK00098
657315006734	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
657315006735	RNA binding site [nucleotide binding]; other site
657315006736	homodimer interface [polypeptide binding]; other site
657315006737	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
657315006738	GTPase/Zn-binding domain interface [polypeptide binding]; other site
657315006739	GTP/Mg2+ binding site [chemical binding]; other site
657315006740	G4 box; other site
657315006741	G5 box; other site
657315006742	G1 box; other site
657315006743	Switch I region; other site
657315006744	G2 box; other site
657315006745	G3 box; other site
657315006746	Switch II region; other site
657315006747	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
657315006748	Catalytic domain of Protein Kinases; Region: PKc; cd00180
657315006749	active site
657315006750	ATP binding site [chemical binding]; other site
657315006751	substrate binding site [chemical binding]; other site
657315006752	activation loop (A-loop); other site
657315006753	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
657315006754	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
657315006755	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
657315006756	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
657315006757	active site
657315006758	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
657315006759	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315006760	FeS/SAM binding site; other site
657315006761	16S rRNA methyltransferase B; Provisional; Region: PRK14902
657315006762	NusB family; Region: NusB; pfam01029
657315006763	putative RNA binding site [nucleotide binding]; other site
657315006764	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
657315006765	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
657315006766	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
657315006767	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
657315006768	putative active site [active]
657315006769	substrate binding site [chemical binding]; other site
657315006770	putative cosubstrate binding site; other site
657315006771	catalytic site [active]
657315006772	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
657315006773	substrate binding site [chemical binding]; other site
657315006774	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
657315006775	active site
657315006776	catalytic residues [active]
657315006777	metal binding site [ion binding]; metal-binding site
657315006778	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
657315006779	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
657315006780	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
657315006781	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
657315006782	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
657315006783	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
657315006784	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
657315006785	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
657315006786	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
657315006787	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
657315006788	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
657315006789	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
657315006790	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
657315006791	HSP70 interaction site [polypeptide binding]; other site
657315006792	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
657315006793	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
657315006794	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
657315006795	active site
657315006796	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
657315006797	Family of unknown function (DUF633); Region: DUF633; pfam04816
657315006798	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
657315006799	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
657315006800	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657315006801	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
657315006802	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657315006803	DNA binding residues [nucleotide binding]
657315006804	DNA primase; Validated; Region: dnaG; PRK05667
657315006805	CHC2 zinc finger; Region: zf-CHC2; pfam01807
657315006806	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
657315006807	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
657315006808	active site
657315006809	metal binding site [ion binding]; metal-binding site
657315006810	interdomain interaction site; other site
657315006811	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
657315006812	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
657315006813	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315006814	Zn2+ binding site [ion binding]; other site
657315006815	Mg2+ binding site [ion binding]; other site
657315006816	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
657315006817	Region found in RelA / SpoT proteins; Region: RelA_SpoT; smart00954
657315006818	PAS domain S-box; Region: sensory_box; TIGR00229
657315006819	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315006820	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315006821	metal binding site [ion binding]; metal-binding site
657315006822	active site
657315006823	I-site; other site
657315006824	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
657315006825	Methyltransferase domain; Region: Methyltransf_31; pfam13847
657315006826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315006827	S-adenosylmethionine binding site [chemical binding]; other site
657315006828	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
657315006829	amidase catalytic site [active]
657315006830	Zn binding residues [ion binding]; other site
657315006831	substrate binding site [chemical binding]; other site
657315006832	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
657315006833	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315006834	FeS/SAM binding site; other site
657315006835	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
657315006836	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657315006837	DNA-binding site [nucleotide binding]; DNA binding site
657315006838	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315006839	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657315006840	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
657315006841	Uncharacterized conserved protein [Function unknown]; Region: COG1434
657315006842	putative active site [active]
657315006843	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
657315006844	active site 1 [active]
657315006845	active site 2 [active]
657315006846	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
657315006847	ATP cone domain; Region: ATP-cone; pfam03477
657315006848	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
657315006849	Transcriptional regulators [Transcription]; Region: MarR; COG1846
657315006850	MarR family; Region: MarR_2; pfam12802
657315006851	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315006852	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315006853	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315006854	Walker A/P-loop; other site
657315006855	ATP binding site [chemical binding]; other site
657315006856	Q-loop/lid; other site
657315006857	ABC transporter signature motif; other site
657315006858	Walker B; other site
657315006859	D-loop; other site
657315006860	H-loop/switch region; other site
657315006861	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315006862	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315006863	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
657315006864	Walker A/P-loop; other site
657315006865	ATP binding site [chemical binding]; other site
657315006866	Q-loop/lid; other site
657315006867	ABC transporter signature motif; other site
657315006868	Walker B; other site
657315006869	D-loop; other site
657315006870	H-loop/switch region; other site
657315006871	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315006872	Zn2+ binding site [ion binding]; other site
657315006873	Mg2+ binding site [ion binding]; other site
657315006874	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
657315006875	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
657315006876	GatB domain; Region: GatB_Yqey; smart00845
657315006877	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
657315006878	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
657315006879	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
657315006880	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
657315006881	Dimer interface [polypeptide binding]; other site
657315006882	anticodon binding site; other site
657315006883	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
657315006884	motif 1; other site
657315006885	dimer interface [polypeptide binding]; other site
657315006886	active site
657315006887	motif 2; other site
657315006888	motif 3; other site
657315006889	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
657315006890	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
657315006891	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
657315006892	active site
657315006893	homodimer interface [polypeptide binding]; other site
657315006894	catalytic site [active]
657315006895	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
657315006896	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
657315006897	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
657315006898	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
657315006899	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
657315006900	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315006901	non-specific DNA binding site [nucleotide binding]; other site
657315006902	salt bridge; other site
657315006903	sequence-specific DNA binding site [nucleotide binding]; other site
657315006904	Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205
657315006905	short chain dehydrogenase; Provisional; Region: PRK05650
657315006906	classical (c) SDRs; Region: SDR_c; cd05233
657315006907	NAD(P) binding site [chemical binding]; other site
657315006908	active site
657315006909	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
657315006910	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
657315006911	Domain of unknown function (DUF4316); Region: DUF4316; pfam14195
657315006912	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315006913	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315006914	non-specific DNA binding site [nucleotide binding]; other site
657315006915	salt bridge; other site
657315006916	sequence-specific DNA binding site [nucleotide binding]; other site
657315006917	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
657315006918	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
657315006919	putative active site [active]
657315006920	putative metal binding site [ion binding]; other site
657315006921	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657315006922	Predicted transcriptional regulators [Transcription]; Region: COG1725
657315006923	DNA-binding site [nucleotide binding]; DNA binding site
657315006924	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
657315006925	FtsX-like permease family; Region: FtsX; pfam02687
657315006926	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
657315006927	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
657315006928	Mg++ binding site [ion binding]; other site
657315006929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315006930	ATP binding site [chemical binding]; other site
657315006931	Mg2+ binding site [ion binding]; other site
657315006932	G-X-G motif; other site
657315006933	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
657315006934	Phage capsid family; Region: Phage_capsid; pfam05065
657315006935	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
657315006936	Uncharacterized conserved protein [Function unknown]; Region: COG4983
657315006937	Phage associated DNA primase [General function prediction only]; Region: COG3378
657315006938	D5 N terminal like; Region: D5_N; smart00885
657315006939	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
657315006940	Helix-turn-helix domain; Region: HTH_17; cl17695
657315006941	Prismane/CO dehydrogenase family; Region: Prismane; pfam03063
657315006942	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
657315006943	homodimer interface [polypeptide binding]; other site
657315006944	putative active site [active]
657315006945	catalytic site [active]
657315006946	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315006947	non-specific DNA binding site [nucleotide binding]; other site
657315006948	salt bridge; other site
657315006949	sequence-specific DNA binding site [nucleotide binding]; other site
657315006950	Winged helix-turn helix; Region: HTH_29; pfam13551
657315006951	Homeodomain-like domain; Region: HTH_32; pfam13565
657315006952	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
657315006953	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
657315006954	active site
657315006955	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315006956	Walker B; other site
657315006957	D-loop; other site
657315006958	H-loop/switch region; other site
657315006959	Domain of unknown function (DUF3825); Region: DUF3825; pfam12873
657315006960	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315006961	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315006962	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315006963	Walker A/P-loop; other site
657315006964	ATP binding site [chemical binding]; other site
657315006965	Q-loop/lid; other site
657315006966	ABC transporter signature motif; other site
657315006967	Walker B; other site
657315006968	D-loop; other site
657315006969	H-loop/switch region; other site
657315006970	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315006971	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315006972	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
657315006973	Walker A/P-loop; other site
657315006974	ATP binding site [chemical binding]; other site
657315006975	Q-loop/lid; other site
657315006976	ABC transporter signature motif; other site
657315006977	Walker B; other site
657315006978	D-loop; other site
657315006979	H-loop/switch region; other site
657315006980	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
657315006981	putative active site [active]
657315006982	nucleotide binding site [chemical binding]; other site
657315006983	nudix motif; other site
657315006984	putative metal binding site [ion binding]; other site
657315006985	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
657315006986	nudix motif; other site
657315006987	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
657315006988	putative active site [active]
657315006989	trigger factor; Provisional; Region: tig; PRK01490
657315006990	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
657315006991	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
657315006992	Clp protease; Region: CLP_protease; pfam00574
657315006993	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
657315006994	oligomer interface [polypeptide binding]; other site
657315006995	active site residues [active]
657315006996	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
657315006997	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
657315006998	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315006999	Walker A motif; other site
657315007000	ATP binding site [chemical binding]; other site
657315007001	Walker B motif; other site
657315007002	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
657315007003	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
657315007004	G1 box; other site
657315007005	GTP/Mg2+ binding site [chemical binding]; other site
657315007006	Switch I region; other site
657315007007	G2 box; other site
657315007008	G3 box; other site
657315007009	Switch II region; other site
657315007010	G4 box; other site
657315007011	G5 box; other site
657315007012	carbamate kinase; Reviewed; Region: PRK12686
657315007013	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
657315007014	putative substrate binding site [chemical binding]; other site
657315007015	nucleotide binding site [chemical binding]; other site
657315007016	nucleotide binding site [chemical binding]; other site
657315007017	homodimer interface [polypeptide binding]; other site
657315007018	pyruvate kinase; Provisional; Region: PRK06354
657315007019	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
657315007020	domain interfaces; other site
657315007021	active site
657315007022	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
657315007023	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657315007024	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315007025	Cupin domain; Region: Cupin_2; pfam07883
657315007026	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315007027	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315007028	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
657315007029	N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754
657315007030	catalytic domain interface [polypeptide binding]; other site
657315007031	homodimer interface [polypeptide binding]; other site
657315007032	putative active site [active]
657315007033	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315007034	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657315007035	DNA binding site [nucleotide binding]
657315007036	domain linker motif; other site
657315007037	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657315007038	dimerization interface [polypeptide binding]; other site
657315007039	ligand binding site [chemical binding]; other site
657315007040	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315007041	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315007042	dimer interface [polypeptide binding]; other site
657315007043	conserved gate region; other site
657315007044	putative PBP binding loops; other site
657315007045	ABC-ATPase subunit interface; other site
657315007046	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315007047	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315007048	dimer interface [polypeptide binding]; other site
657315007049	conserved gate region; other site
657315007050	putative PBP binding loops; other site
657315007051	ABC-ATPase subunit interface; other site
657315007052	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
657315007053	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657315007054	active site
657315007055	HIGH motif; other site
657315007056	nucleotide binding site [chemical binding]; other site
657315007057	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
657315007058	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
657315007059	active site
657315007060	KMSKS motif; other site
657315007061	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
657315007062	tRNA binding surface [nucleotide binding]; other site
657315007063	anticodon binding site; other site
657315007064	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
657315007065	Protein of unknown function (DUF342); Region: DUF342; pfam03961
657315007066	Tetratricopeptide repeat; Region: TPR_16; pfam13432
657315007067	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
657315007068	binding surface
657315007069	TPR motif; other site
657315007070	Tetratricopeptide repeat; Region: TPR_12; pfam13424
657315007071	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
657315007072	binding surface
657315007073	TPR motif; other site
657315007074	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
657315007075	anti sigma factor interaction site; other site
657315007076	regulatory phosphorylation site [posttranslational modification]; other site
657315007077	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
657315007078	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315007079	ATP binding site [chemical binding]; other site
657315007080	Mg2+ binding site [ion binding]; other site
657315007081	G-X-G motif; other site
657315007082	sporulation sigma factor SigF; Validated; Region: PRK05572
657315007083	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657315007084	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
657315007085	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657315007086	DNA binding residues [nucleotide binding]
657315007087	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
657315007088	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315007089	motif II; other site
657315007090	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
657315007091	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315007092	Zn2+ binding site [ion binding]; other site
657315007093	Mg2+ binding site [ion binding]; other site
657315007094	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
657315007095	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
657315007096	ligand binding site [chemical binding]; other site
657315007097	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
657315007098	4Fe-4S binding domain; Region: Fer4_6; pfam12837
657315007099	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
657315007100	hybrid cluster protein; Provisional; Region: PRK05290
657315007101	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657315007102	ACS interaction site; other site
657315007103	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
657315007104	hybrid metal cluster; other site
657315007105	PAS domain; Region: PAS_9; pfam13426
657315007106	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
657315007107	GAF domain; Region: GAF_3; pfam13492
657315007108	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315007109	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315007110	metal binding site [ion binding]; metal-binding site
657315007111	active site
657315007112	I-site; other site
657315007113	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
657315007114	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
657315007115	active site
657315007116	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315007117	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315007118	non-specific DNA binding site [nucleotide binding]; other site
657315007119	salt bridge; other site
657315007120	sequence-specific DNA binding site [nucleotide binding]; other site
657315007121	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
657315007122	Mg binding site [ion binding]; other site
657315007123	nucleotide binding site [chemical binding]; other site
657315007124	putative protofilament interface [polypeptide binding]; other site
657315007125	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
657315007126	MPN+ (JAMM) motif; other site
657315007127	Zinc-binding site [ion binding]; other site
657315007128	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
657315007129	Toprim-like; Region: Toprim_2; pfam13155
657315007130	active site
657315007131	metal binding site [ion binding]; metal-binding site
657315007132	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
657315007133	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
657315007134	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
657315007135	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657315007136	Walker A motif; other site
657315007137	ATP binding site [chemical binding]; other site
657315007138	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
657315007139	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
657315007140	Domain of unknown function (DUF4313); Region: DUF4313; pfam14190
657315007141	PrgI family protein; Region: PrgI; pfam12666
657315007142	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
657315007143	AAA-like domain; Region: AAA_10; pfam12846
657315007144	Domain of unknown function DUF87; Region: DUF87; pfam01935
657315007145	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
657315007146	NlpC/P60 family; Region: NLPC_P60; cl17555
657315007147	DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207
657315007148	Methyltransferase domain; Region: Methyltransf_26; pfam13659
657315007149	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
657315007150	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
657315007151	DEAD-like helicases superfamily; Region: DEXDc; smart00487
657315007152	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
657315007153	ATP binding site [chemical binding]; other site
657315007154	putative Mg++ binding site [ion binding]; other site
657315007155	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
657315007156	helicase superfamily c-terminal domain; Region: HELICc; smart00490
657315007157	nucleotide binding region [chemical binding]; other site
657315007158	ATP-binding site [chemical binding]; other site
657315007159	Sortase family; Region: Sortase; pfam04203
657315007160	active site
657315007161	catalytic site [active]
657315007162	SpoVG; Region: SpoVG; cl00915
657315007163	SpoVG; Region: SpoVG; pfam04026
657315007164	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657315007165	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315007166	catalytic residues [active]
657315007167	catalytic nucleophile [active]
657315007168	Recombinase; Region: Recombinase; pfam07508
657315007169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
657315007170	H+ Antiporter protein; Region: 2A0121; TIGR00900
657315007171	putative substrate translocation pore; other site
657315007172	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
657315007173	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
657315007174	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
657315007175	metal binding site [ion binding]; metal-binding site
657315007176	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
657315007177	Methyltransferase domain; Region: Methyltransf_11; pfam08241
657315007178	Methyltransferase domain; Region: Methyltransf_12; pfam08242
657315007179	Methyltransferase domain; Region: Methyltransf_23; pfam13489
657315007180	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
657315007181	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
657315007182	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315007183	S-adenosylmethionine binding site [chemical binding]; other site
657315007184	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
657315007185	Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068
657315007186	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315007187	FeS/SAM binding site; other site
657315007188	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
657315007189	Peptidase S8 family domain, uncharacterized subfamily 8; Region: Peptidases_S8_8; cd07492
657315007190	active site
657315007191	catalytic triad [active]
657315007192	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315007193	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315007194	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315007195	Walker A/P-loop; other site
657315007196	ATP binding site [chemical binding]; other site
657315007197	Q-loop/lid; other site
657315007198	ABC transporter signature motif; other site
657315007199	Walker B; other site
657315007200	D-loop; other site
657315007201	H-loop/switch region; other site
657315007202	Protein of unknown function (DUF419); Region: DUF419; cl15265
657315007203	Protein of unknown function DUF45; Region: DUF45; pfam01863
657315007204	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
657315007205	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
657315007206	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
657315007207	active site
657315007208	metal binding site [ion binding]; metal-binding site
657315007209	CTP synthetase; Validated; Region: pyrG; PRK05380
657315007210	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
657315007211	Catalytic site [active]
657315007212	active site
657315007213	UTP binding site [chemical binding]; other site
657315007214	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
657315007215	active site
657315007216	putative oxyanion hole; other site
657315007217	catalytic triad [active]
657315007218	FtsH Extracellular; Region: FtsH_ext; pfam06480
657315007219	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
657315007220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315007221	Walker A motif; other site
657315007222	ATP binding site [chemical binding]; other site
657315007223	Walker B motif; other site
657315007224	arginine finger; other site
657315007225	Peptidase family M41; Region: Peptidase_M41; pfam01434
657315007226	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
657315007227	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
657315007228	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
657315007229	Hpr binding site; other site
657315007230	active site
657315007231	homohexamer subunit interaction site [polypeptide binding]; other site
657315007232	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
657315007233	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
657315007234	oligomer interface [polypeptide binding]; other site
657315007235	putative active site [active]
657315007236	metal binding site [ion binding]; metal-binding site
657315007237	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
657315007238	FAD binding domain; Region: FAD_binding_4; pfam01565
657315007239	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
657315007240	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
657315007241	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
657315007242	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
657315007243	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
657315007244	dimerization domain swap beta strand [polypeptide binding]; other site
657315007245	regulatory protein interface [polypeptide binding]; other site
657315007246	active site
657315007247	regulatory phosphorylation site [posttranslational modification]; other site
657315007248	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
657315007249	putative lipid kinase; Reviewed; Region: PRK13337
657315007250	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
657315007251	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
657315007252	intersubunit interface [polypeptide binding]; other site
657315007253	active site
657315007254	zinc binding site [ion binding]; other site
657315007255	Na+ binding site [ion binding]; other site
657315007256	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
657315007257	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
657315007258	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
657315007259	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
657315007260	Nitrogen regulatory protein P-II; Region: P-II; smart00938
657315007261	ammonium transporter; Region: amt; TIGR00836
657315007262	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
657315007263	active site
657315007264	NTP binding site [chemical binding]; other site
657315007265	metal binding triad [ion binding]; metal-binding site
657315007266	antibiotic binding site [chemical binding]; other site
657315007267	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
657315007268	active site
657315007269	NTP binding site [chemical binding]; other site
657315007270	metal binding triad [ion binding]; metal-binding site
657315007271	antibiotic binding site [chemical binding]; other site
657315007272	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
657315007273	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
657315007274	active site
657315007275	ATP binding site [chemical binding]; other site
657315007276	substrate binding site [chemical binding]; other site
657315007277	activation loop (A-loop); other site
657315007278	AAA ATPase domain; Region: AAA_16; pfam13191
657315007279	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
657315007280	Mor transcription activator family; Region: Mor; cl02360
657315007281	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
657315007282	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
657315007283	Transglycosylase; Region: Transgly; pfam00912
657315007284	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
657315007285	Uncharacterized conserved protein [Function unknown]; Region: COG1739
657315007286	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
657315007287	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
657315007288	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
657315007289	active site
657315007290	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
657315007291	S1 domain; Region: S1_2; pfam13509
657315007292	S1 domain; Region: S1_2; pfam13509
657315007293	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
657315007294	RNA binding site [nucleotide binding]; other site
657315007295	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
657315007296	homotrimer interaction site [polypeptide binding]; other site
657315007297	putative active site [active]
657315007298	Putative motility protein; Region: YjfB_motility; pfam14070
657315007299	Bacterial SH3 domain; Region: SH3_3; pfam08239
657315007300	Bacterial SH3 domain; Region: SH3_3; pfam08239
657315007301	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
657315007302	NlpC/P60 family; Region: NLPC_P60; pfam00877
657315007303	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
657315007304	Carbon starvation protein CstA; Region: CstA; pfam02554
657315007305	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
657315007306	Glycosyl transferase WecB/TagA/CpsF family; Region: Glyco_tran_WecB; pfam03808
657315007307	Uncharacterized conserved protein [Function unknown]; Region: COG1284
657315007308	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
657315007309	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
657315007310	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
657315007311	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
657315007312	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315007313	Walker A/P-loop; other site
657315007314	ATP binding site [chemical binding]; other site
657315007315	Q-loop/lid; other site
657315007316	ABC transporter signature motif; other site
657315007317	Walker B; other site
657315007318	D-loop; other site
657315007319	H-loop/switch region; other site
657315007320	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
657315007321	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
657315007322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
657315007323	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
657315007324	Peptidase family M23; Region: Peptidase_M23; pfam01551
657315007325	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
657315007326	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
657315007327	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
657315007328	protein binding site [polypeptide binding]; other site
657315007329	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
657315007330	Catalytic dyad [active]
657315007331	Predicted integral membrane protein [Function unknown]; Region: COG5652
657315007332	peptide chain release factor 2; Provisional; Region: PRK05589
657315007333	PCRF domain; Region: PCRF; pfam03462
657315007334	RF-1 domain; Region: RF-1; pfam00472
657315007335	Tim44-like domain; Region: Tim44; cl09208
657315007336	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
657315007337	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
657315007338	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
657315007339	Double zinc ribbon; Region: DZR; pfam12773
657315007340	Repair protein; Region: Repair_PSII; pfam04536
657315007341	hypothetical protein; Provisional; Region: PRK04435
657315007342	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
657315007343	DNA-binding interface [nucleotide binding]; DNA binding site
657315007344	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
657315007345	homoserine dehydrogenase; Provisional; Region: PRK06349
657315007346	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
657315007347	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
657315007348	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
657315007349	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838
657315007350	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
657315007351	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
657315007352	catalytic site [active]
657315007353	subunit interface [polypeptide binding]; other site
657315007354	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
657315007355	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
657315007356	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
657315007357	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
657315007358	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
657315007359	ATP-grasp domain; Region: ATP-grasp_4; cl17255
657315007360	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
657315007361	IMP binding site; other site
657315007362	dimer interface [polypeptide binding]; other site
657315007363	interdomain contacts; other site
657315007364	partial ornithine binding site; other site
657315007365	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
657315007366	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315007367	Zn2+ binding site [ion binding]; other site
657315007368	Mg2+ binding site [ion binding]; other site
657315007369	putative acyltransferase; Provisional; Region: PRK05790
657315007370	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
657315007371	dimer interface [polypeptide binding]; other site
657315007372	active site
657315007373	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
657315007374	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
657315007375	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
657315007376	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
657315007377	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
657315007378	FAD binding site [chemical binding]; other site
657315007379	homotetramer interface [polypeptide binding]; other site
657315007380	substrate binding pocket [chemical binding]; other site
657315007381	catalytic base [active]
657315007382	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
657315007383	Ligand binding site [chemical binding]; other site
657315007384	Electron transfer flavoprotein domain; Region: ETF; pfam01012
657315007385	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
657315007386	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
657315007387	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
657315007388	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
657315007389	Predicted membrane protein [Function unknown]; Region: COG4684
657315007390	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
657315007391	Predicted membrane protein [Function unknown]; Region: COG4684
657315007392	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
657315007393	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
657315007394	ApbE family; Region: ApbE; pfam02424
657315007395	FMN-binding domain; Region: FMN_bind; cl01081
657315007396	FMN-binding domain; Region: FMN_bind; cl01081
657315007397	FMN-binding domain; Region: FMN_bind; cl01081
657315007398	FMN-binding domain; Region: FMN_bind; cl01081
657315007399	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
657315007400	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
657315007401	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
657315007402	GMP synthase; Reviewed; Region: guaA; PRK00074
657315007403	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
657315007404	AMP/PPi binding site [chemical binding]; other site
657315007405	candidate oxyanion hole; other site
657315007406	catalytic triad [active]
657315007407	potential glutamine specificity residues [chemical binding]; other site
657315007408	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
657315007409	ATP Binding subdomain [chemical binding]; other site
657315007410	Ligand Binding sites [chemical binding]; other site
657315007411	Dimerization subdomain; other site
657315007412	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315007413	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315007414	non-specific DNA binding site [nucleotide binding]; other site
657315007415	salt bridge; other site
657315007416	sequence-specific DNA binding site [nucleotide binding]; other site
657315007417	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
657315007418	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
657315007419	Int/Topo IB signature motif; other site
657315007420	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657315007421	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
657315007422	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
657315007423	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
657315007424	Transposase; Region: DEDD_Tnp_IS110; pfam01548
657315007425	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
657315007426	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
657315007427	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
657315007428	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
657315007429	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315007430	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
657315007431	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
657315007432	Mg binding site [ion binding]; other site
657315007433	nucleotide binding site [chemical binding]; other site
657315007434	putative protofilament interface [polypeptide binding]; other site
657315007435	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
657315007436	Toprim-like; Region: Toprim_2; pfam13155
657315007437	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
657315007438	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
657315007439	AAA-like domain; Region: AAA_10; pfam12846
657315007440	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657315007441	Walker A motif; other site
657315007442	ATP binding site [chemical binding]; other site
657315007443	Walker B motif; other site
657315007444	Domain of unknown function (DUF4313); Region: DUF4313; pfam14190
657315007445	PrgI family protein; Region: PrgI; pfam12666
657315007446	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
657315007447	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
657315007448	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
657315007449	AAA-like domain; Region: AAA_10; pfam12846
657315007450	Domain of unknown function DUF87; Region: DUF87; pfam01935
657315007451	DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207
657315007452	SpoVG; Region: SpoVG; cl00915
657315007453	SpoVG; Region: SpoVG; pfam04026
657315007454	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
657315007455	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
657315007456	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
657315007457	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657315007458	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657315007459	DNA binding residues [nucleotide binding]
657315007460	Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112
657315007461	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
657315007462	MFS/sugar transport protein; Region: MFS_2; pfam13347
657315007463	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
657315007464	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
657315007465	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
657315007466	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
657315007467	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
657315007468	methylglyoxal synthase; Validated; Region: mgsA; PRK05234
657315007469	substrate binding site [chemical binding]; other site
657315007470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315007471	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657315007472	active site
657315007473	phosphorylation site [posttranslational modification]
657315007474	intermolecular recognition site; other site
657315007475	dimerization interface [polypeptide binding]; other site
657315007476	LytTr DNA-binding domain; Region: LytTR; pfam04397
657315007477	Staphylococcal AgrD protein; Region: AgrD; cl05477
657315007478	Accessory gene regulator B; Region: AgrB; pfam04647
657315007479	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657315007480	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315007481	active site
657315007482	phosphorylation site [posttranslational modification]
657315007483	intermolecular recognition site; other site
657315007484	LytTr DNA-binding domain; Region: LytTR; pfam04397
657315007485	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
657315007486	Accessory gene regulator B; Region: AgrB; pfam04647
657315007487	Staphylococcal AgrD protein; Region: AgrD; cl05477
657315007488	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
657315007489	Transposase; Region: DEDD_Tnp_IS110; pfam01548
657315007490	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
657315007491	TFIIF-interacting CTD phosphatases, including NLI-interacting factor [Transcription]; Region: FCP1; COG5190
657315007492	PemK-like protein; Region: PemK; pfam02452
657315007493	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315007494	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657315007495	catalytic residues [active]
657315007496	catalytic nucleophile [active]
657315007497	Recombinase; Region: Recombinase; pfam07508
657315007498	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657315007499	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315007500	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657315007501	catalytic residues [active]
657315007502	catalytic nucleophile [active]
657315007503	Recombinase; Region: Recombinase; pfam07508
657315007504	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657315007505	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657315007506	catalytic residues [active]
657315007507	catalytic nucleophile [active]
657315007508	Recombinase; Region: Recombinase; pfam07508
657315007509	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
657315007510	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
657315007511	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
657315007512	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
657315007513	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
657315007514	dimer interface [polypeptide binding]; other site
657315007515	active site
657315007516	metal binding site [ion binding]; metal-binding site
657315007517	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315007518	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315007519	non-specific DNA binding site [nucleotide binding]; other site
657315007520	salt bridge; other site
657315007521	sequence-specific DNA binding site [nucleotide binding]; other site
657315007522	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
657315007523	Int/Topo IB signature motif; other site
657315007524	AAA domain; Region: AAA_25; pfam13481
657315007525	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657315007526	Walker A motif; other site
657315007527	ATP binding site [chemical binding]; other site
657315007528	Walker B motif; other site
657315007529	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657315007530	Helix-turn-helix domain; Region: HTH_17; pfam12728
657315007531	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
657315007532	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
657315007533	cofactor binding site; other site
657315007534	DNA binding site [nucleotide binding]
657315007535	substrate interaction site [chemical binding]; other site
657315007536	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
657315007537	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315007538	S-adenosylmethionine binding site [chemical binding]; other site
657315007539	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
657315007540	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
657315007541	active site
657315007542	integrase; Provisional; Region: int; PHA02601
657315007543	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
657315007544	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
657315007545	Int/Topo IB signature motif; other site
657315007546	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315007547	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315007548	non-specific DNA binding site [nucleotide binding]; other site
657315007549	salt bridge; other site
657315007550	sequence-specific DNA binding site [nucleotide binding]; other site
657315007551	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
657315007552	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
657315007553	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
657315007554	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
657315007555	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
657315007556	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657315007557	Coenzyme A binding pocket [chemical binding]; other site
657315007558	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
657315007559	catalytic core [active]
657315007560	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
657315007561	Part of AAA domain; Region: AAA_19; pfam13245
657315007562	AAA domain; Region: AAA_12; pfam13087
657315007563	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
657315007564	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
657315007565	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
657315007566	nudix motif; other site
657315007567	AAA ATPase domain; Region: AAA_15; pfam13175
657315007568	P-loop containing region of AAA domain; Region: AAA_29; cl17516
657315007569	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
657315007570	putative active site [active]
657315007571	putative metal-binding site [ion binding]; other site
657315007572	Part of AAA domain; Region: AAA_19; pfam13245
657315007573	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
657315007574	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
657315007575	Divergent AAA domain; Region: AAA_4; pfam04326
657315007576	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
657315007577	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315007578	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
657315007579	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
657315007580	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
657315007581	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
657315007582	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
657315007583	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
657315007584	Fumarase C-terminus; Region: Fumerase_C; cl00795
657315007585	fumarate hydratase; Provisional; Region: PRK06246
657315007586	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
657315007587	CsbD-like; Region: CsbD; cl17424
657315007588	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
657315007589	tetramerization interface [polypeptide binding]; other site
657315007590	active site
657315007591	pantoate--beta-alanine ligase; Region: panC; TIGR00018
657315007592	Pantoate-beta-alanine ligase; Region: PanC; cd00560
657315007593	active site
657315007594	ATP-binding site [chemical binding]; other site
657315007595	pantoate-binding site; other site
657315007596	HXXH motif; other site
657315007597	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
657315007598	oligomerization interface [polypeptide binding]; other site
657315007599	active site
657315007600	metal binding site [ion binding]; metal-binding site
657315007601	Uncharacterized conserved protein [Function unknown]; Region: COG5495
657315007602	Rossmann-like domain; Region: Rossmann-like; pfam10727
657315007603	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
657315007604	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
657315007605	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
657315007606	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
657315007607	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
657315007608	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657315007609	LytTr DNA-binding domain; Region: LytTR; smart00850
657315007610	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315007611	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
657315007612	Walker A/P-loop; other site
657315007613	ATP binding site [chemical binding]; other site
657315007614	Q-loop/lid; other site
657315007615	ABC transporter signature motif; other site
657315007616	Walker B; other site
657315007617	D-loop; other site
657315007618	H-loop/switch region; other site
657315007619	HipA-like C-terminal domain; Region: HipA_C; pfam07804
657315007620	DNA gyrase subunit A; Validated; Region: PRK05560
657315007621	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
657315007622	CAP-like domain; other site
657315007623	active site
657315007624	primary dimer interface [polypeptide binding]; other site
657315007625	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657315007626	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657315007627	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657315007628	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657315007629	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657315007630	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657315007631	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
657315007632	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315007633	Mg2+ binding site [ion binding]; other site
657315007634	G-X-G motif; other site
657315007635	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
657315007636	anchoring element; other site
657315007637	dimer interface [polypeptide binding]; other site
657315007638	ATP binding site [chemical binding]; other site
657315007639	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
657315007640	active site
657315007641	putative metal-binding site [ion binding]; other site
657315007642	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
657315007643	recombination protein F; Reviewed; Region: recF; PRK00064
657315007644	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
657315007645	Walker A/P-loop; other site
657315007646	ATP binding site [chemical binding]; other site
657315007647	Q-loop/lid; other site
657315007648	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315007649	ABC transporter signature motif; other site
657315007650	Walker B; other site
657315007651	D-loop; other site
657315007652	H-loop/switch region; other site
657315007653	S4 domain; Region: S4_2; pfam13275
657315007654	DNA polymerase III subunit beta; Validated; Region: PRK05643
657315007655	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
657315007656	putative DNA binding surface [nucleotide binding]; other site
657315007657	dimer interface [polypeptide binding]; other site
657315007658	beta-clamp/clamp loader binding surface; other site
657315007659	beta-clamp/translesion DNA polymerase binding surface; other site
657315007660	DnaA N-terminal domain; Region: DnaA_N; pfam11638
657315007661	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
657315007662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315007663	Walker A motif; other site
657315007664	ATP binding site [chemical binding]; other site
657315007665	Walker B motif; other site
657315007666	arginine finger; other site
657315007667	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
657315007668	DnaA box-binding interface [nucleotide binding]; other site
657315007669	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
657315007670	ribonuclease P; Reviewed; Region: rnpA; PRK00499
657315007671	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
657315007672	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
657315007673	G-X-X-G motif; other site
657315007674	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
657315007675	RxxxH motif; other site
657315007676	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
657315007677	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
657315007678	trmE is a tRNA modification GTPase; Region: trmE; cd04164
657315007679	G1 box; other site
657315007680	GTP/Mg2+ binding site [chemical binding]; other site
657315007681	Switch I region; other site
657315007682	G2 box; other site
657315007683	Switch II region; other site
657315007684	G3 box; other site
657315007685	G4 box; other site
657315007686	G5 box; other site
657315007687	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
657315007688	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
657315007689	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
657315007690	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
657315007691	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
657315007692	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
657315007693	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315007694	S-adenosylmethionine binding site [chemical binding]; other site
657315007695	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
657315007696	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
657315007697	Histidine kinase; Region: HisKA_3; pfam07730
657315007698	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315007699	ATP binding site [chemical binding]; other site
657315007700	Mg2+ binding site [ion binding]; other site
657315007701	G-X-G motif; other site
657315007702	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
657315007703	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315007704	active site
657315007705	phosphorylation site [posttranslational modification]
657315007706	intermolecular recognition site; other site
657315007707	dimerization interface [polypeptide binding]; other site
657315007708	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
657315007709	DNA binding residues [nucleotide binding]
657315007710	dimerization interface [polypeptide binding]; other site
657315007711	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
657315007712	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657315007713	P-loop; other site
657315007714	Magnesium ion binding site [ion binding]; other site
657315007715	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657315007716	Magnesium ion binding site [ion binding]; other site
657315007717	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
657315007718	ParB-like nuclease domain; Region: ParB; smart00470
657315007719	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
657315007720	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315007721	Zn2+ binding site [ion binding]; other site
657315007722	Mg2+ binding site [ion binding]; other site
657315007723	Domain of unknown function, E. rectale Gene description (DUF3881); Region: DUF3881; pfam12997
657315007724	Fic family protein [Function unknown]; Region: COG3177
657315007725	Fic/DOC family; Region: Fic; pfam02661
657315007726	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
657315007727	non-specific DNA interactions [nucleotide binding]; other site
657315007728	DNA binding site [nucleotide binding]
657315007729	sequence specific DNA binding site [nucleotide binding]; other site
657315007730	putative cAMP binding site [chemical binding]; other site
657315007731	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315007732	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315007733	dimer interface [polypeptide binding]; other site
657315007734	putative CheW interface [polypeptide binding]; other site
657315007735	Transposase domain (DUF772); Region: DUF772; pfam05598
657315007736	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
657315007737	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
657315007738	ParB-like nuclease domain; Region: ParBc; pfam02195
657315007739	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
657315007740	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
657315007741	inhibitor binding site; inhibition site
657315007742	active site
657315007743	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
657315007744	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
657315007745	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
657315007746	catalytic tetrad [active]
657315007747	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
657315007748	Beta-lactamase; Region: Beta-lactamase; pfam00144
657315007749	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
657315007750	Beta-lactamase; Region: Beta-lactamase; pfam00144
657315007751	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
657315007752	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315007753	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
657315007754	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
657315007755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315007756	dimer interface [polypeptide binding]; other site
657315007757	conserved gate region; other site
657315007758	putative PBP binding loops; other site
657315007759	ABC-ATPase subunit interface; other site
657315007760	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315007761	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315007762	dimer interface [polypeptide binding]; other site
657315007763	conserved gate region; other site
657315007764	putative PBP binding loops; other site
657315007765	ABC-ATPase subunit interface; other site
657315007766	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315007767	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315007768	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657315007769	DNA binding site [nucleotide binding]
657315007770	domain linker motif; other site
657315007771	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657315007772	dimerization interface [polypeptide binding]; other site
657315007773	ligand binding site [chemical binding]; other site
657315007774	N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858
657315007775	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
657315007776	Putative esterase; Region: Esterase; pfam00756
657315007777	N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858
657315007778	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
657315007779	Putative esterase; Region: Esterase; pfam00756
657315007780	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
657315007781	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
657315007782	Putative esterase; Region: Esterase; pfam00756
657315007783	Putative esterase; Region: Esterase; pfam00756
657315007784	S-formylglutathione hydrolase; Region: PLN02442
657315007785	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315007786	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657315007787	Right handed beta helix region; Region: Beta_helix; pfam13229
657315007788	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
657315007789	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
657315007790	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
657315007791	substrate binding site [chemical binding]; other site
657315007792	active site
657315007793	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
657315007794	ligand binding site [chemical binding]; other site
657315007795	metal binding site [ion binding]; metal-binding site
657315007796	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
657315007797	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
657315007798	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
657315007799	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315007800	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315007801	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
657315007802	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
657315007803	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
657315007804	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
657315007805	hypothetical protein; Reviewed; Region: PRK09588
657315007806	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315007807	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315007808	non-specific DNA binding site [nucleotide binding]; other site
657315007809	salt bridge; other site
657315007810	sequence-specific DNA binding site [nucleotide binding]; other site
657315007811	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315007812	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315007813	non-specific DNA binding site [nucleotide binding]; other site
657315007814	salt bridge; other site
657315007815	sequence-specific DNA binding site [nucleotide binding]; other site
657315007816	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
657315007817	AAA domain; Region: AAA_14; pfam13173
657315007818	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
657315007819	active site
657315007820	putative interdomain interaction site [polypeptide binding]; other site
657315007821	putative metal-binding site [ion binding]; other site
657315007822	putative nucleotide binding site [chemical binding]; other site
657315007823	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
657315007824	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
657315007825	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657315007826	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657315007827	Q-loop/lid; other site
657315007828	ABC transporter signature motif; other site
657315007829	Walker B; other site
657315007830	D-loop; other site
657315007831	H-loop/switch region; other site
657315007832	FtsX-like permease family; Region: FtsX; pfam02687
657315007833	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
657315007834	FtsX-like permease family; Region: FtsX; pfam02687
657315007835	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
657315007836	active site
657315007837	metal binding site [ion binding]; metal-binding site
657315007838	Bacterial DNA topoisomerase I DNA-binding domain; Region: TOP1Ac; smart00437
657315007839	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
657315007840	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
657315007841	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315007842	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315007843	dimer interface [polypeptide binding]; other site
657315007844	putative CheW interface [polypeptide binding]; other site
657315007845	Flavodoxin domain; Region: Flavodoxin_3; pfam12641
657315007846	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
657315007847	homodimer interface [polypeptide binding]; other site
657315007848	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
657315007849	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
657315007850	active site
657315007851	homodimer interface [polypeptide binding]; other site
657315007852	catalytic site [active]
657315007853	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315007854	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
657315007855	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657315007856	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657315007857	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657315007858	dimerization interface [polypeptide binding]; other site
657315007859	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
657315007860	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
657315007861	transmembrane helices; other site
657315007862	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
657315007863	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
657315007864	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
657315007865	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
657315007866	dimerization interface [polypeptide binding]; other site
657315007867	putative Zn2+ binding site [ion binding]; other site
657315007868	putative DNA binding site [nucleotide binding]; other site
657315007869	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315007870	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657315007871	hypothetical protein; Provisional; Region: PHA03169
657315007872	peptidase T; Region: peptidase-T; TIGR01882
657315007873	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
657315007874	metal binding site [ion binding]; metal-binding site
657315007875	dimer interface [polypeptide binding]; other site
657315007876	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315007877	S-adenosylmethionine binding site [chemical binding]; other site
657315007878	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
657315007879	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
657315007880	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
657315007881	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
657315007882	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
657315007883	GTP binding site; other site
657315007884	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
657315007885	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
657315007886	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657315007887	catalytic residue [active]
657315007888	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
657315007889	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
657315007890	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
657315007891	active site
657315007892	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
657315007893	DNA polymerase III subunit delta'; Validated; Region: PRK08485
657315007894	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
657315007895	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
657315007896	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
657315007897	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
657315007898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315007899	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
657315007900	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315007901	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315007902	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
657315007903	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
657315007904	putative ligand binding residues [chemical binding]; other site
657315007905	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
657315007906	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
657315007907	ABC-ATPase subunit  interface; other site
657315007908	dimer interface [polypeptide binding]; other site
657315007909	putative PBP binding regions; other site
657315007910	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
657315007911	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
657315007912	ABC-ATPase subunit  interface; other site
657315007913	dimer interface [polypeptide binding]; other site
657315007914	putative PBP binding regions; other site
657315007915	iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231
657315007916	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
657315007917	Walker A/P-loop; other site
657315007918	ATP binding site [chemical binding]; other site
657315007919	Q-loop/lid; other site
657315007920	ABC transporter signature motif; other site
657315007921	Walker B; other site
657315007922	D-loop; other site
657315007923	H-loop/switch region; other site
657315007924	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
657315007925	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
657315007926	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
657315007927	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
657315007928	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
657315007929	DNA binding residues [nucleotide binding]
657315007930	dimerization interface [polypeptide binding]; other site
657315007931	Isochorismatase family; Region: Isochorismatase; pfam00857
657315007932	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
657315007933	catalytic triad [active]
657315007934	conserved cis-peptide bond; other site
657315007935	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
657315007936	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
657315007937	substrate binding pocket [chemical binding]; other site
657315007938	membrane-bound complex binding site; other site
657315007939	hinge residues; other site
657315007940	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
657315007941	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
657315007942	DNA binding residues [nucleotide binding]
657315007943	dimerization interface [polypeptide binding]; other site
657315007944	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
657315007945	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
657315007946	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
657315007947	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
657315007948	urea carboxylase; Region: urea_carbox; TIGR02712
657315007949	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
657315007950	ATP-grasp domain; Region: ATP-grasp_4; cl17255
657315007951	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
657315007952	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
657315007953	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
657315007954	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
657315007955	carboxyltransferase (CT) interaction site; other site
657315007956	biotinylation site [posttranslational modification]; other site
657315007957	allophanate hydrolase; Provisional; Region: PRK08186
657315007958	Amidase; Region: Amidase; cl11426
657315007959	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
657315007960	Nitrogen regulatory protein P-II; Region: P-II; smart00938
657315007961	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
657315007962	Nitrogen regulatory protein P-II; Region: P-II; smart00938
657315007963	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
657315007964	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
657315007965	substrate binding pocket [chemical binding]; other site
657315007966	membrane-bound complex binding site; other site
657315007967	hinge residues; other site
657315007968	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
657315007969	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
657315007970	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
657315007971	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
657315007972	Walker A/P-loop; other site
657315007973	ATP binding site [chemical binding]; other site
657315007974	Q-loop/lid; other site
657315007975	ABC transporter signature motif; other site
657315007976	Walker B; other site
657315007977	D-loop; other site
657315007978	H-loop/switch region; other site
657315007979	Predicted methyltransferases [General function prediction only]; Region: COG0313
657315007980	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
657315007981	putative SAM binding site [chemical binding]; other site
657315007982	putative homodimer interface [polypeptide binding]; other site
657315007983	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
657315007984	Response regulator receiver domain; Region: Response_reg; pfam00072
657315007985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315007986	active site
657315007987	phosphorylation site [posttranslational modification]
657315007988	intermolecular recognition site; other site
657315007989	dimerization interface [polypeptide binding]; other site
657315007990	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315007991	metal binding site [ion binding]; metal-binding site
657315007992	active site
657315007993	I-site; other site
657315007994	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
657315007995	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
657315007996	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
657315007997	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315007998	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315007999	dimer interface [polypeptide binding]; other site
657315008000	putative CheW interface [polypeptide binding]; other site
657315008001	NAD-dependent deacetylase; Provisional; Region: PRK00481
657315008002	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
657315008003	Tubby C 2; Region: Tub_2; cl02043
657315008004	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
657315008005	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
657315008006	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
657315008007	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
657315008008	dimer interface [polypeptide binding]; other site
657315008009	ssDNA binding site [nucleotide binding]; other site
657315008010	tetramer (dimer of dimers) interface [polypeptide binding]; other site
657315008011	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
657315008012	Cache domain; Region: Cache_1; pfam02743
657315008013	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315008014	dimerization interface [polypeptide binding]; other site
657315008015	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315008016	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315008017	dimer interface [polypeptide binding]; other site
657315008018	putative CheW interface [polypeptide binding]; other site
657315008019	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
657315008020	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
657315008021	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
657315008022	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
657315008023	substrate binding [chemical binding]; other site
657315008024	active site
657315008025	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315008026	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657315008027	DNA binding site [nucleotide binding]
657315008028	domain linker motif; other site
657315008029	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657315008030	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
657315008031	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
657315008032	Ca binding site [ion binding]; other site
657315008033	active site
657315008034	catalytic site [active]
657315008035	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
657315008036	Melibiase; Region: Melibiase; pfam02065
657315008037	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
657315008038	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
657315008039	putative substrate binding site [chemical binding]; other site
657315008040	putative ATP binding site [chemical binding]; other site
657315008041	Protein of unknown function (DUF805); Region: DUF805; pfam05656
657315008042	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
657315008043	DHH family; Region: DHH; pfam01368
657315008044	DHHA1 domain; Region: DHHA1; pfam02272
657315008045	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
657315008046	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
657315008047	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
657315008048	replicative DNA helicase; Region: DnaB; TIGR00665
657315008049	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
657315008050	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
657315008051	Walker A motif; other site
657315008052	ATP binding site [chemical binding]; other site
657315008053	Walker B motif; other site
657315008054	DNA binding loops [nucleotide binding]
657315008055	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
657315008056	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764
657315008057	DNA binding residues [nucleotide binding]
657315008058	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552
657315008059	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
657315008060	active site
657315008061	NTP binding site [chemical binding]; other site
657315008062	metal binding triad [ion binding]; metal-binding site
657315008063	antibiotic binding site [chemical binding]; other site
657315008064	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315008065	Walker A motif; other site
657315008066	ATP binding site [chemical binding]; other site
657315008067	Walker B motif; other site
657315008068	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
657315008069	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
657315008070	active site
657315008071	catalytic residues [active]
657315008072	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
657315008073	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
657315008074	Low molecular weight phosphatase family; Region: LMWPc; cl00105
657315008075	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
657315008076	active site
657315008077	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657315008078	active site
657315008079	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
657315008080	catalytic motif [active]
657315008081	Zn binding site [ion binding]; other site
657315008082	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
657315008083	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
657315008084	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
657315008085	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
657315008086	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
657315008087	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
657315008088	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
657315008089	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
657315008090	beta subunit interaction interface [polypeptide binding]; other site
657315008091	Walker A motif; other site
657315008092	ATP binding site [chemical binding]; other site
657315008093	Walker B motif; other site
657315008094	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
657315008095	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
657315008096	core domain interface [polypeptide binding]; other site
657315008097	delta subunit interface [polypeptide binding]; other site
657315008098	epsilon subunit interface [polypeptide binding]; other site
657315008099	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
657315008100	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
657315008101	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
657315008102	alpha subunit interaction interface [polypeptide binding]; other site
657315008103	Walker A motif; other site
657315008104	ATP binding site [chemical binding]; other site
657315008105	Walker B motif; other site
657315008106	inhibitor binding site; inhibition site
657315008107	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
657315008108	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
657315008109	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
657315008110	gamma subunit interface [polypeptide binding]; other site
657315008111	epsilon subunit interface [polypeptide binding]; other site
657315008112	LBP interface [polypeptide binding]; other site
657315008113	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657315008114	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315008115	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315008116	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657315008117	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
657315008118	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315008119	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315008120	non-specific DNA binding site [nucleotide binding]; other site
657315008121	salt bridge; other site
657315008122	sequence-specific DNA binding site [nucleotide binding]; other site
657315008123	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657315008124	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657315008125	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657315008126	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657315008127	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
657315008128	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657315008129	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657315008130	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
657315008131	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
657315008132	catalytic core [active]
657315008133	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
657315008134	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
657315008135	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
657315008136	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
657315008137	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
657315008138	putative substrate binding site [chemical binding]; other site
657315008139	putative ATP binding site [chemical binding]; other site
657315008140	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
657315008141	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
657315008142	active site
657315008143	phosphorylation site [posttranslational modification]
657315008144	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
657315008145	active site
657315008146	P-loop; other site
657315008147	phosphorylation site [posttranslational modification]
657315008148	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
657315008149	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
657315008150	dimerization domain swap beta strand [polypeptide binding]; other site
657315008151	regulatory protein interface [polypeptide binding]; other site
657315008152	active site
657315008153	regulatory phosphorylation site [posttranslational modification]; other site
657315008154	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
657315008155	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
657315008156	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
657315008157	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
657315008158	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
657315008159	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
657315008160	active site
657315008161	VanW like protein; Region: VanW; pfam04294
657315008162	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
657315008163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315008164	S-adenosylmethionine binding site [chemical binding]; other site
657315008165	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
657315008166	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
657315008167	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
657315008168	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
657315008169	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
657315008170	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
657315008171	Walker A/P-loop; other site
657315008172	ATP binding site [chemical binding]; other site
657315008173	Q-loop/lid; other site
657315008174	ABC transporter signature motif; other site
657315008175	Walker B; other site
657315008176	D-loop; other site
657315008177	H-loop/switch region; other site
657315008178	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
657315008179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315008180	dimer interface [polypeptide binding]; other site
657315008181	conserved gate region; other site
657315008182	putative PBP binding loops; other site
657315008183	ABC-ATPase subunit interface; other site
657315008184	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
657315008185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315008186	dimer interface [polypeptide binding]; other site
657315008187	conserved gate region; other site
657315008188	ABC-ATPase subunit interface; other site
657315008189	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
657315008190	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
657315008191	active site
657315008192	metal binding site [ion binding]; metal-binding site
657315008193	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
657315008194	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
657315008195	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
657315008196	active site
657315008197	dimer interface [polypeptide binding]; other site
657315008198	motif 1; other site
657315008199	motif 2; other site
657315008200	motif 3; other site
657315008201	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
657315008202	anticodon binding site; other site
657315008203	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
657315008204	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
657315008205	active site
657315008206	metal binding site [ion binding]; metal-binding site
657315008207	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
657315008208	Transcriptional regulator [Transcription]; Region: LytR; COG1316
657315008209	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315008210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315008211	active site
657315008212	phosphorylation site [posttranslational modification]
657315008213	intermolecular recognition site; other site
657315008214	dimerization interface [polypeptide binding]; other site
657315008215	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315008216	DNA binding site [nucleotide binding]
657315008217	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315008218	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315008219	dimer interface [polypeptide binding]; other site
657315008220	phosphorylation site [posttranslational modification]
657315008221	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315008222	ATP binding site [chemical binding]; other site
657315008223	Mg2+ binding site [ion binding]; other site
657315008224	G-X-G motif; other site
657315008225	putative hydratase; Provisional; Region: PRK11413
657315008226	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
657315008227	substrate binding site [chemical binding]; other site
657315008228	ligand binding site [chemical binding]; other site
657315008229	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
657315008230	substrate binding site [chemical binding]; other site
657315008231	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
657315008232	Domain of unknown function DUF20; Region: UPF0118; pfam01594
657315008233	glycogen branching enzyme; Provisional; Region: PRK12313
657315008234	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
657315008235	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
657315008236	active site
657315008237	catalytic site [active]
657315008238	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
657315008239	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
657315008240	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
657315008241	active site
657315008242	metal binding site [ion binding]; metal-binding site
657315008243	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
657315008244	active site
657315008245	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
657315008246	Catalytic domain of Protein Kinases; Region: PKc; cd00180
657315008247	active site
657315008248	ATP binding site [chemical binding]; other site
657315008249	substrate binding site [chemical binding]; other site
657315008250	activation loop (A-loop); other site
657315008251	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
657315008252	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
657315008253	flagellin; Provisional; Region: PRK12806
657315008254	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
657315008255	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
657315008256	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
657315008257	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
657315008258	ATP binding site [chemical binding]; other site
657315008259	Walker A motif; other site
657315008260	hexamer interface [polypeptide binding]; other site
657315008261	Walker B motif; other site
657315008262	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
657315008263	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
657315008264	TadE-like protein; Region: TadE; pfam07811
657315008265	Rhomboid family; Region: Rhomboid; pfam01694
657315008266	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
657315008267	SCP-2 sterol transfer family; Region: SCP2; pfam02036
657315008268	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
657315008269	HIT family signature motif; other site
657315008270	catalytic residue [active]
657315008271	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
657315008272	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
657315008273	active site
657315008274	homodimer interface [polypeptide binding]; other site
657315008275	Bacterial SH3 domain; Region: SH3_3; cl17532
657315008276	Bacterial SH3 domain; Region: SH3_3; pfam08239
657315008277	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
657315008278	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
657315008279	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
657315008280	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315008281	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315008282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315008283	ATP binding site [chemical binding]; other site
657315008284	G-X-G motif; other site
657315008285	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657315008286	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657315008287	Walker A/P-loop; other site
657315008288	ATP binding site [chemical binding]; other site
657315008289	Q-loop/lid; other site
657315008290	ABC transporter signature motif; other site
657315008291	Walker B; other site
657315008292	D-loop; other site
657315008293	H-loop/switch region; other site
657315008294	FtsX-like permease family; Region: FtsX; pfam02687
657315008295	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
657315008296	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315008297	motif II; other site
657315008298	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315008299	DNA binding site [nucleotide binding]
657315008300	Int/Topo IB signature motif; other site
657315008301	active site
657315008302	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
657315008303	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315008304	non-specific DNA binding site [nucleotide binding]; other site
657315008305	salt bridge; other site
657315008306	sequence-specific DNA binding site [nucleotide binding]; other site
657315008307	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315008308	salt bridge; other site
657315008309	non-specific DNA binding site [nucleotide binding]; other site
657315008310	sequence-specific DNA binding site [nucleotide binding]; other site
657315008311	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315008312	non-specific DNA binding site [nucleotide binding]; other site
657315008313	salt bridge; other site
657315008314	sequence-specific DNA binding site [nucleotide binding]; other site
657315008315	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315008316	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315008317	non-specific DNA binding site [nucleotide binding]; other site
657315008318	salt bridge; other site
657315008319	sequence-specific DNA binding site [nucleotide binding]; other site
657315008320	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
657315008321	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
657315008322	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
657315008323	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
657315008324	N-acetyl-D-glucosamine binding site [chemical binding]; other site
657315008325	catalytic residue [active]
657315008326	NlpC/P60 family; Region: NLPC_P60; pfam00877
657315008327	hypothetical protein; Provisional; Region: PRK13795
657315008328	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
657315008329	Active Sites [active]
657315008330	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
657315008331	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
657315008332	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
657315008333	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657315008334	catalytic residue [active]
657315008335	Protein of unknown function DUF262; Region: DUF262; pfam03235
657315008336	Uncharacterized conserved protein [Function unknown]; Region: COG3472
657315008337	Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513
657315008338	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
657315008339	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
657315008340	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315008341	metal binding site [ion binding]; metal-binding site
657315008342	active site
657315008343	I-site; other site
657315008344	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
657315008345	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
657315008346	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
657315008347	folate binding site [chemical binding]; other site
657315008348	NADP+ binding site [chemical binding]; other site
657315008349	Predicted permeases [General function prediction only]; Region: COG0679
657315008350	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
657315008351	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
657315008352	PYR/PP interface [polypeptide binding]; other site
657315008353	dimer interface [polypeptide binding]; other site
657315008354	TPP binding site [chemical binding]; other site
657315008355	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
657315008356	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
657315008357	TPP-binding site [chemical binding]; other site
657315008358	dimer interface [polypeptide binding]; other site
657315008359	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
657315008360	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
657315008361	putative valine binding site [chemical binding]; other site
657315008362	dimer interface [polypeptide binding]; other site
657315008363	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
657315008364	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
657315008365	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
657315008366	dimerization interface [polypeptide binding]; other site
657315008367	domain crossover interface; other site
657315008368	redox-dependent activation switch; other site
657315008369	NAD synthetase; Reviewed; Region: nadE; PRK02628
657315008370	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
657315008371	multimer interface [polypeptide binding]; other site
657315008372	active site
657315008373	catalytic triad [active]
657315008374	protein interface 1 [polypeptide binding]; other site
657315008375	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
657315008376	homodimer interface [polypeptide binding]; other site
657315008377	NAD binding pocket [chemical binding]; other site
657315008378	ATP binding pocket [chemical binding]; other site
657315008379	Mg binding site [ion binding]; other site
657315008380	active-site loop [active]
657315008381	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
657315008382	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
657315008383	active site
657315008384	catalytic tetrad [active]
657315008385	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657315008386	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
657315008387	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
657315008388	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
657315008389	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315008390	non-specific DNA binding site [nucleotide binding]; other site
657315008391	salt bridge; other site
657315008392	sequence-specific DNA binding site [nucleotide binding]; other site
657315008393	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
657315008394	SpoVA protein; Region: SpoVA; pfam03862
657315008395	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
657315008396	nucleotide binding site/active site [active]
657315008397	HIT family signature motif; other site
657315008398	catalytic residue [active]
657315008399	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
657315008400	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
657315008401	active site
657315008402	intersubunit interface [polypeptide binding]; other site
657315008403	catalytic residue [active]
657315008404	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
657315008405	Transcriptional regulator [Transcription]; Region: IclR; COG1414
657315008406	Bacterial transcriptional regulator; Region: IclR; pfam01614
657315008407	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
657315008408	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315008409	Walker A motif; other site
657315008410	ATP binding site [chemical binding]; other site
657315008411	Walker B motif; other site
657315008412	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
657315008413	Cache domain; Region: Cache_1; pfam02743
657315008414	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315008415	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315008416	dimer interface [polypeptide binding]; other site
657315008417	putative CheW interface [polypeptide binding]; other site
657315008418	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
657315008419	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
657315008420	active site
657315008421	catalytic triad [active]
657315008422	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
657315008423	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
657315008424	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657315008425	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657315008426	Walker A/P-loop; other site
657315008427	ATP binding site [chemical binding]; other site
657315008428	Q-loop/lid; other site
657315008429	ABC transporter signature motif; other site
657315008430	Walker B; other site
657315008431	D-loop; other site
657315008432	H-loop/switch region; other site
657315008433	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
657315008434	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
657315008435	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657315008436	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
657315008437	FtsX-like permease family; Region: FtsX; pfam02687
657315008438	seryl-tRNA synthetase; Provisional; Region: PRK05431
657315008439	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
657315008440	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
657315008441	motif 1; other site
657315008442	dimer interface [polypeptide binding]; other site
657315008443	active site
657315008444	motif 2; other site
657315008445	motif 3; other site
657315008446	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
657315008447	active site
657315008448	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
657315008449	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
657315008450	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
657315008451	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
657315008452	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
657315008453	ATP synthase subunit C; Region: ATP-synt_C; cl00466
657315008454	ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990
657315008455	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
657315008456	V-type ATP synthase subunit A; Provisional; Region: PRK04192
657315008457	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
657315008458	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
657315008459	Walker A motif/ATP binding site; other site
657315008460	Walker B motif; other site
657315008461	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
657315008462	V-type ATP synthase subunit B; Provisional; Region: PRK04196
657315008463	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
657315008464	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
657315008465	Walker A motif homologous position; other site
657315008466	Walker B motif; other site
657315008467	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
657315008468	ATP synthase subunit D; Region: ATP-synt_D; pfam01813
657315008469	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
657315008470	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
657315008471	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
657315008472	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
657315008473	HD domain; Region: HD_3; pfam13023
657315008474	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
657315008475	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
657315008476	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
657315008477	dimerization interface [polypeptide binding]; other site
657315008478	putative ATP binding site [chemical binding]; other site
657315008479	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
657315008480	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
657315008481	active site
657315008482	substrate binding site [chemical binding]; other site
657315008483	cosubstrate binding site; other site
657315008484	catalytic site [active]
657315008485	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
657315008486	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
657315008487	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
657315008488	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
657315008489	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
657315008490	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
657315008491	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
657315008492	ligand binding site [chemical binding]; other site
657315008493	calcium binding site [ion binding]; other site
657315008494	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
657315008495	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
657315008496	Walker A/P-loop; other site
657315008497	ATP binding site [chemical binding]; other site
657315008498	Q-loop/lid; other site
657315008499	ABC transporter signature motif; other site
657315008500	Walker B; other site
657315008501	D-loop; other site
657315008502	H-loop/switch region; other site
657315008503	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
657315008504	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
657315008505	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
657315008506	TM-ABC transporter signature motif; other site
657315008507	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
657315008508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315008509	active site
657315008510	phosphorylation site [posttranslational modification]
657315008511	intermolecular recognition site; other site
657315008512	dimerization interface [polypeptide binding]; other site
657315008513	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315008514	Cache domain; Region: Cache_1; pfam02743
657315008515	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315008516	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
657315008517	Histidine kinase; Region: His_kinase; pfam06580
657315008518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315008519	ATP binding site [chemical binding]; other site
657315008520	Mg2+ binding site [ion binding]; other site
657315008521	G-X-G motif; other site
657315008522	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657315008523	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
657315008524	ligand binding site [chemical binding]; other site
657315008525	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
657315008526	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
657315008527	ligand binding site [chemical binding]; other site
657315008528	calcium binding site [ion binding]; other site
657315008529	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
657315008530	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
657315008531	glutaminase active site [active]
657315008532	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
657315008533	dimer interface [polypeptide binding]; other site
657315008534	active site
657315008535	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
657315008536	dimer interface [polypeptide binding]; other site
657315008537	active site
657315008538	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
657315008539	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
657315008540	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
657315008541	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
657315008542	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
657315008543	dimerization interface 3.5A [polypeptide binding]; other site
657315008544	active site
657315008545	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
657315008546	DHH family; Region: DHH; pfam01368
657315008547	DHHA1 domain; Region: DHHA1; pfam02272
657315008548	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315008549	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315008550	putative CheW interface [polypeptide binding]; other site
657315008551	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
657315008552	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
657315008553	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
657315008554	Predicted secreted protein [Function unknown]; Region: COG4086
657315008555	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
657315008556	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
657315008557	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
657315008558	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
657315008559	active site
657315008560	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
657315008561	Predicted transcriptional regulators [Transcription]; Region: COG1695
657315008562	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
657315008563	Predicted membrane protein [Function unknown]; Region: COG4709
657315008564	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
657315008565	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
657315008566	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
657315008567	putative active site [active]
657315008568	putative metal binding site [ion binding]; other site
657315008569	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
657315008570	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
657315008571	CAAX protease self-immunity; Region: Abi; pfam02517
657315008572	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657315008573	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315008574	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315008575	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315008576	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
657315008577	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
657315008578	active site
657315008579	substrate binding site [chemical binding]; other site
657315008580	metal binding site [ion binding]; metal-binding site
657315008581	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
657315008582	Melibiase; Region: Melibiase; pfam02065
657315008583	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315008584	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657315008585	DNA binding site [nucleotide binding]
657315008586	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657315008587	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315008588	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657315008589	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315008590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315008591	dimer interface [polypeptide binding]; other site
657315008592	conserved gate region; other site
657315008593	putative PBP binding loops; other site
657315008594	ABC-ATPase subunit interface; other site
657315008595	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315008596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315008597	dimer interface [polypeptide binding]; other site
657315008598	conserved gate region; other site
657315008599	putative PBP binding loops; other site
657315008600	ABC-ATPase subunit interface; other site
657315008601	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
657315008602	putative active cleft [active]
657315008603	dimerization interface [polypeptide binding]; other site
657315008604	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
657315008605	active site
657315008606	Domain of unknown function (DUF377); Region: DUF377; pfam04041
657315008607	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
657315008608	active site
657315008609	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
657315008610	active site
657315008611	catalytic triad [active]
657315008612	oxyanion hole [active]
657315008613	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
657315008614	active site
657315008615	catalytic triad [active]
657315008616	oxyanion hole [active]
657315008617	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
657315008618	beta-galactosidase; Region: BGL; TIGR03356
657315008619	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
657315008620	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
657315008621	AAA domain; Region: AAA_14; pfam13173
657315008622	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
657315008623	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
657315008624	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
657315008625	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
657315008626	homodimer interface [polypeptide binding]; other site
657315008627	NADP binding site [chemical binding]; other site
657315008628	substrate binding site [chemical binding]; other site
657315008629	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
657315008630	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
657315008631	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
657315008632	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315008633	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315008634	non-specific DNA binding site [nucleotide binding]; other site
657315008635	salt bridge; other site
657315008636	sequence-specific DNA binding site [nucleotide binding]; other site
657315008637	Integrase core domain; Region: rve; pfam00665
657315008638	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
657315008639	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315008640	non-specific DNA binding site [nucleotide binding]; other site
657315008641	salt bridge; other site
657315008642	sequence-specific DNA binding site [nucleotide binding]; other site
657315008643	AAA domain; Region: AAA_22; pfam13401
657315008644	Protein of unknown function (DUF1018); Region: DUF1018; cl01815
657315008645	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
657315008646	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
657315008647	amidase catalytic site [active]
657315008648	Zn binding residues [ion binding]; other site
657315008649	substrate binding site [chemical binding]; other site
657315008650	Bacterial SH3 domain; Region: SH3_3; pfam08239
657315008651	Mor transcription activator family; Region: Mor; cl02360
657315008652	Ketol-acid reductoisomerase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvC; COG0059
657315008653	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
657315008654	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
657315008655	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
657315008656	Protein of unknown function (DUF935); Region: DUF935; pfam06074
657315008657	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
657315008658	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
657315008659	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
657315008660	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
657315008661	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
657315008662	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
657315008663	Protein of unknown function (DUF2586); Region: DUF2586; pfam10758
657315008664	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
657315008665	Phage-related protein [Function unknown]; Region: COG5412
657315008666	Baseplate J-like protein; Region: Baseplate_J; pfam04865
657315008667	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
657315008668	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
657315008669	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
657315008670	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657315008671	Zn2+ binding site [ion binding]; other site
657315008672	Mg2+ binding site [ion binding]; other site
657315008673	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
657315008674	Clp amino terminal domain; Region: Clp_N; pfam02861
657315008675	Clp amino terminal domain; Region: Clp_N; pfam02861
657315008676	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315008677	Walker A motif; other site
657315008678	ATP binding site [chemical binding]; other site
657315008679	Walker B motif; other site
657315008680	arginine finger; other site
657315008681	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315008682	Walker A motif; other site
657315008683	ATP binding site [chemical binding]; other site
657315008684	Walker B motif; other site
657315008685	arginine finger; other site
657315008686	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
657315008687	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315008688	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657315008689	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
657315008690	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
657315008691	active site
657315008692	nucleophile elbow; other site
657315008693	beta-phosphoglucomutase; Region: bPGM; TIGR01990
657315008694	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315008695	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315008696	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657315008697	DNA binding site [nucleotide binding]
657315008698	domain linker motif; other site
657315008699	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657315008700	dimerization interface [polypeptide binding]; other site
657315008701	ligand binding site [chemical binding]; other site
657315008702	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315008703	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
657315008704	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315008705	dimer interface [polypeptide binding]; other site
657315008706	conserved gate region; other site
657315008707	putative PBP binding loops; other site
657315008708	ABC-ATPase subunit interface; other site
657315008709	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315008710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315008711	dimer interface [polypeptide binding]; other site
657315008712	conserved gate region; other site
657315008713	putative PBP binding loops; other site
657315008714	ABC-ATPase subunit interface; other site
657315008715	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
657315008716	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
657315008717	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
657315008718	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
657315008719	Protein of unknown function, DUF624; Region: DUF624; cl02369
657315008720	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
657315008721	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
657315008722	putative active site [active]
657315008723	putative catalytic site [active]
657315008724	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
657315008725	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
657315008726	Ca binding site [ion binding]; other site
657315008727	active site
657315008728	catalytic site [active]
657315008729	pullulanase, type I; Region: pulA_typeI; TIGR02104
657315008730	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
657315008731	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
657315008732	Ca binding site [ion binding]; other site
657315008733	active site
657315008734	catalytic site [active]
657315008735	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
657315008736	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
657315008737	active site
657315008738	PHP Thumb interface [polypeptide binding]; other site
657315008739	metal binding site [ion binding]; metal-binding site
657315008740	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
657315008741	generic binding surface II; other site
657315008742	generic binding surface I; other site
657315008743	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315008744	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315008745	non-specific DNA binding site [nucleotide binding]; other site
657315008746	salt bridge; other site
657315008747	sequence-specific DNA binding site [nucleotide binding]; other site
657315008748	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
657315008749	AAA-like domain; Region: AAA_10; pfam12846
657315008750	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657315008751	CpXC protein; Region: CpXC; pfam14353
657315008752	6-phosphofructokinase; Provisional; Region: PRK03202
657315008753	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
657315008754	active site
657315008755	ADP/pyrophosphate binding site [chemical binding]; other site
657315008756	dimerization interface [polypeptide binding]; other site
657315008757	allosteric effector site; other site
657315008758	fructose-1,6-bisphosphate binding site; other site
657315008759	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
657315008760	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
657315008761	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
657315008762	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
657315008763	Fic/DOC family; Region: Fic; cl00960
657315008764	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
657315008765	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
657315008766	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
657315008767	synthetase active site [active]
657315008768	NTP binding site [chemical binding]; other site
657315008769	metal binding site [ion binding]; metal-binding site
657315008770	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657315008771	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315008772	active site
657315008773	phosphorylation site [posttranslational modification]
657315008774	intermolecular recognition site; other site
657315008775	dimerization interface [polypeptide binding]; other site
657315008776	LytTr DNA-binding domain; Region: LytTR; pfam04397
657315008777	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
657315008778	ATP binding site [chemical binding]; other site
657315008779	Mg2+ binding site [ion binding]; other site
657315008780	G-X-G motif; other site
657315008781	LemA family; Region: LemA; cl00742
657315008782	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
657315008783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
657315008784	hypothetical protein; Provisional; Region: PRK13663
657315008785	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
657315008786	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657315008787	ABC transporter; Region: ABC_tran_2; pfam12848
657315008788	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315008789	Walker A/P-loop; other site
657315008790	ATP binding site [chemical binding]; other site
657315008791	Q-loop/lid; other site
657315008792	ABC transporter signature motif; other site
657315008793	Walker B; other site
657315008794	D-loop; other site
657315008795	H-loop/switch region; other site
657315008796	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
657315008797	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315008798	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315008799	metal binding site [ion binding]; metal-binding site
657315008800	active site
657315008801	I-site; other site
657315008802	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315008803	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315008804	dimer interface [polypeptide binding]; other site
657315008805	phosphorylation site [posttranslational modification]
657315008806	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
657315008807	Uncharacterized conserved protein [Function unknown]; Region: COG2966
657315008808	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
657315008809	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
657315008810	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
657315008811	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
657315008812	Domain of unknown function (DUF3837); Region: DUF3837; pfam12939
657315008813	Cupin domain; Region: Cupin_2; cl17218
657315008814	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657315008815	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
657315008816	SpoVA protein; Region: SpoVA; pfam03862
657315008817	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
657315008818	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
657315008819	active site
657315008820	NAD binding site [chemical binding]; other site
657315008821	metal binding site [ion binding]; metal-binding site
657315008822	hybrid cluster protein; Provisional; Region: PRK05290
657315008823	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657315008824	ACS interaction site; other site
657315008825	CODH interaction site; other site
657315008826	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657315008827	ACS interaction site; other site
657315008828	CODH interaction site; other site
657315008829	metal cluster binding site [ion binding]; other site
657315008830	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315008831	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
657315008832	active site
657315008833	motif I; other site
657315008834	motif II; other site
657315008835	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
657315008836	putative substrate binding pocket [chemical binding]; other site
657315008837	AC domain interface; other site
657315008838	catalytic triad [active]
657315008839	AB domain interface; other site
657315008840	interchain disulfide; other site
657315008841	HlyD family secretion protein; Region: HlyD_3; pfam13437
657315008842	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
657315008843	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
657315008844	HlyD family secretion protein; Region: HlyD_3; pfam13437
657315008845	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657315008846	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657315008847	FtsX-like permease family; Region: FtsX; pfam02687
657315008848	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657315008849	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657315008850	Walker A/P-loop; other site
657315008851	ATP binding site [chemical binding]; other site
657315008852	Q-loop/lid; other site
657315008853	ABC transporter signature motif; other site
657315008854	Walker B; other site
657315008855	D-loop; other site
657315008856	H-loop/switch region; other site
657315008857	A new structural DNA glycosylase; Region: AlkD_like; cd06561
657315008858	active site
657315008859	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
657315008860	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
657315008861	active site
657315008862	dimerization interface [polypeptide binding]; other site
657315008863	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315008864	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315008865	non-specific DNA binding site [nucleotide binding]; other site
657315008866	salt bridge; other site
657315008867	sequence-specific DNA binding site [nucleotide binding]; other site
657315008868	NPCBM/NEW2 domain; Region: NPCBM; cl07060
657315008869	Surface antigen [General function prediction only]; Region: COG3942
657315008870	CHAP domain; Region: CHAP; pfam05257
657315008871	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
657315008872	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
657315008873	Double zinc ribbon; Region: DZR; pfam12773
657315008874	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
657315008875	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
657315008876	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
657315008877	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
657315008878	Probable beta-xylosidase; Provisional; Region: PLN03080
657315008879	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
657315008880	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
657315008881	HAMP domain; Region: HAMP; pfam00672
657315008882	Histidine kinase; Region: His_kinase; pfam06580
657315008883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315008884	ATP binding site [chemical binding]; other site
657315008885	Mg2+ binding site [ion binding]; other site
657315008886	G-X-G motif; other site
657315008887	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
657315008888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315008889	active site
657315008890	phosphorylation site [posttranslational modification]
657315008891	intermolecular recognition site; other site
657315008892	dimerization interface [polypeptide binding]; other site
657315008893	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315008894	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657315008895	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
657315008896	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315008897	dimer interface [polypeptide binding]; other site
657315008898	conserved gate region; other site
657315008899	putative PBP binding loops; other site
657315008900	ABC-ATPase subunit interface; other site
657315008901	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315008902	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315008903	conserved gate region; other site
657315008904	ABC-ATPase subunit interface; other site
657315008905	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
657315008906	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
657315008907	active site
657315008908	catalytic triad [active]
657315008909	oxyanion hole [active]
657315008910	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
657315008911	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
657315008912	inhibitor binding site; inhibition site
657315008913	active site
657315008914	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315008915	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657315008916	DNA binding site [nucleotide binding]
657315008917	domain linker motif; other site
657315008918	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657315008919	dimerization interface [polypeptide binding]; other site
657315008920	ligand binding site [chemical binding]; other site
657315008921	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
657315008922	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315008923	dimer interface [polypeptide binding]; other site
657315008924	conserved gate region; other site
657315008925	putative PBP binding loops; other site
657315008926	ABC-ATPase subunit interface; other site
657315008927	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315008928	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315008929	dimer interface [polypeptide binding]; other site
657315008930	conserved gate region; other site
657315008931	putative PBP binding loops; other site
657315008932	ABC-ATPase subunit interface; other site
657315008933	Cupin domain; Region: Cupin_2; cl17218
657315008934	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315008935	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657315008936	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657315008937	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
657315008938	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
657315008939	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
657315008940	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
657315008941	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
657315008942	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
657315008943	galactokinase; Provisional; Region: PRK05322
657315008944	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
657315008945	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
657315008946	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
657315008947	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
657315008948	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
657315008949	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
657315008950	aspartate aminotransferase; Provisional; Region: PRK06836
657315008951	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657315008952	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315008953	homodimer interface [polypeptide binding]; other site
657315008954	catalytic residue [active]
657315008955	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
657315008956	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657315008957	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315008958	homodimer interface [polypeptide binding]; other site
657315008959	catalytic residue [active]
657315008960	CAAX protease self-immunity; Region: Abi; pfam02517
657315008961	Trp repressor protein; Region: Trp_repressor; cl17266
657315008962	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
657315008963	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
657315008964	Part of AAA domain; Region: AAA_19; pfam13245
657315008965	Family description; Region: UvrD_C_2; pfam13538
657315008966	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
657315008967	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315008968	S-adenosylmethionine binding site [chemical binding]; other site
657315008969	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657315008970	hypothetical protein; Validated; Region: PRK08116
657315008971	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315008972	Walker A motif; other site
657315008973	ATP binding site [chemical binding]; other site
657315008974	Walker B motif; other site
657315008975	arginine finger; other site
657315008976	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
657315008977	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
657315008978	nucleotide binding site [chemical binding]; other site
657315008979	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
657315008980	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
657315008981	putative NAD(P) binding site [chemical binding]; other site
657315008982	catalytic Zn binding site [ion binding]; other site
657315008983	structural Zn binding site [ion binding]; other site
657315008984	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
657315008985	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
657315008986	active site
657315008987	metal binding site [ion binding]; metal-binding site
657315008988	MFS/sugar transport protein; Region: MFS_2; pfam13347
657315008989	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657315008990	putative substrate translocation pore; other site
657315008991	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
657315008992	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
657315008993	putative substrate binding site [chemical binding]; other site
657315008994	putative ATP binding site [chemical binding]; other site
657315008995	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657315008996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315008997	dimer interface [polypeptide binding]; other site
657315008998	conserved gate region; other site
657315008999	putative PBP binding loops; other site
657315009000	ABC-ATPase subunit interface; other site
657315009001	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
657315009002	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657315009003	Coenzyme A binding pocket [chemical binding]; other site
657315009004	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
657315009005	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
657315009006	putative active site [active]
657315009007	PhoH-like protein; Region: PhoH; pfam02562
657315009008	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
657315009009	HSP70 interaction site [polypeptide binding]; other site
657315009010	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
657315009011	catalytic core [active]
657315009012	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
657315009013	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657315009014	ligand binding site [chemical binding]; other site
657315009015	dimerization interface [polypeptide binding]; other site
657315009016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315009017	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
657315009018	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
657315009019	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
657315009020	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
657315009021	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315009022	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315009023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657315009024	Walker A/P-loop; other site
657315009025	ATP binding site [chemical binding]; other site
657315009026	Q-loop/lid; other site
657315009027	ABC transporter signature motif; other site
657315009028	Walker B; other site
657315009029	D-loop; other site
657315009030	H-loop/switch region; other site
657315009031	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657315009032	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657315009033	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
657315009034	Walker A/P-loop; other site
657315009035	ATP binding site [chemical binding]; other site
657315009036	Q-loop/lid; other site
657315009037	ABC transporter signature motif; other site
657315009038	Walker B; other site
657315009039	D-loop; other site
657315009040	H-loop/switch region; other site
657315009041	Transcriptional regulators [Transcription]; Region: FadR; COG2186
657315009042	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657315009043	DNA-binding site [nucleotide binding]; DNA binding site
657315009044	FCD domain; Region: FCD; pfam07729
657315009045	Cache domain; Region: Cache_1; pfam02743
657315009046	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657315009047	dimerization interface [polypeptide binding]; other site
657315009048	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315009049	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315009050	metal binding site [ion binding]; metal-binding site
657315009051	active site
657315009052	I-site; other site
657315009053	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315009054	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315009055	dimer interface [polypeptide binding]; other site
657315009056	putative CheW interface [polypeptide binding]; other site
657315009057	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
657315009058	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
657315009059	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
657315009060	putative active site [active]
657315009061	catalytic site [active]
657315009062	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
657315009063	putative active site [active]
657315009064	catalytic site [active]
657315009065	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
657315009066	synthetase active site [active]
657315009067	NTP binding site [chemical binding]; other site
657315009068	metal binding site [ion binding]; metal-binding site
657315009069	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
657315009070	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657315009071	catalytic residue [active]
657315009072	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
657315009073	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
657315009074	DNA-binding site [nucleotide binding]; DNA binding site
657315009075	RNA-binding motif; other site
657315009076	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
657315009077	EDD domain protein, DegV family; Region: DegV; TIGR00762
657315009078	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
657315009079	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
657315009080	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
657315009081	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
657315009082	enolase; Provisional; Region: eno; PRK00077
657315009083	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
657315009084	dimer interface [polypeptide binding]; other site
657315009085	metal binding site [ion binding]; metal-binding site
657315009086	substrate binding pocket [chemical binding]; other site
657315009087	ribonuclease R; Region: RNase_R; TIGR02063
657315009088	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
657315009089	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
657315009090	RNB domain; Region: RNB; pfam00773
657315009091	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
657315009092	RNA binding site [nucleotide binding]; other site
657315009093	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
657315009094	SmpB-tmRNA interface; other site
657315009095	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
657315009096	putative active site [active]
657315009097	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657315009098	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657315009099	DNA binding site [nucleotide binding]
657315009100	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
657315009101	ligand binding site [chemical binding]; other site
657315009102	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
657315009103	N- and C-terminal domain interface [polypeptide binding]; other site
657315009104	D-xylulose kinase; Region: XylB; TIGR01312
657315009105	active site
657315009106	MgATP binding site [chemical binding]; other site
657315009107	catalytic site [active]
657315009108	metal binding site [ion binding]; metal-binding site
657315009109	xylulose binding site [chemical binding]; other site
657315009110	homodimer interface [polypeptide binding]; other site
657315009111	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
657315009112	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
657315009113	hexamer (dimer of trimers) interface [polypeptide binding]; other site
657315009114	substrate binding site [chemical binding]; other site
657315009115	trimer interface [polypeptide binding]; other site
657315009116	Mn binding site [ion binding]; other site
657315009117	Bacterial SH3 domain; Region: SH3_3; pfam08239
657315009118	Bacterial SH3 domain; Region: SH3_3; pfam08239
657315009119	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
657315009120	NlpC/P60 family; Region: NLPC_P60; pfam00877
657315009121	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
657315009122	regulatory protein interface [polypeptide binding]; other site
657315009123	regulatory phosphorylation site [posttranslational modification]; other site
657315009124	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
657315009125	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
657315009126	DEAD_2; Region: DEAD_2; pfam06733
657315009127	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
657315009128	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657315009129	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657315009130	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657315009131	dimerization interface [polypeptide binding]; other site
657315009132	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
657315009133	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
657315009134	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
657315009135	dimerization interface [polypeptide binding]; other site
657315009136	ATP binding site [chemical binding]; other site
657315009137	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
657315009138	dimerization interface [polypeptide binding]; other site
657315009139	ATP binding site [chemical binding]; other site
657315009140	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
657315009141	putative active site [active]
657315009142	catalytic triad [active]
657315009143	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
657315009144	DHHW protein; Region: DHHW; pfam14286
657315009145	DHHW protein; Region: DHHW; pfam14286
657315009146	histidinol-phosphatase; Provisional; Region: PRK05588
657315009147	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
657315009148	active site
657315009149	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
657315009150	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
657315009151	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
657315009152	Phosphoglycerate kinase; Region: PGK; pfam00162
657315009153	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
657315009154	substrate binding site [chemical binding]; other site
657315009155	hinge regions; other site
657315009156	ADP binding site [chemical binding]; other site
657315009157	catalytic site [active]
657315009158	triosephosphate isomerase; Provisional; Region: PRK14567
657315009159	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
657315009160	substrate binding site [chemical binding]; other site
657315009161	dimer interface [polypeptide binding]; other site
657315009162	catalytic triad [active]
657315009163	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
657315009164	phosphoglyceromutase; Provisional; Region: PRK05434
657315009165	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
657315009166	ATP binding site [chemical binding]; other site
657315009167	active site
657315009168	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
657315009169	substrate binding site [chemical binding]; other site
657315009170	amidophosphoribosyltransferase; Provisional; Region: PRK05793
657315009171	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
657315009172	active site
657315009173	tetramer interface [polypeptide binding]; other site
657315009174	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657315009175	active site
657315009176	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
657315009177	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
657315009178	tetramer interface [polypeptide binding]; other site
657315009179	active site
657315009180	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
657315009181	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
657315009182	dimer interface [polypeptide binding]; other site
657315009183	active site
657315009184	metal binding site [ion binding]; metal-binding site
657315009185	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
657315009186	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
657315009187	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
657315009188	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
657315009189	putative N- and C-terminal domain interface [polypeptide binding]; other site
657315009190	putative active site [active]
657315009191	MgATP binding site [chemical binding]; other site
657315009192	catalytic site [active]
657315009193	metal binding site [ion binding]; metal-binding site
657315009194	putative carbohydrate binding site [chemical binding]; other site
657315009195	L-arabinose isomerase; Provisional; Region: PRK02929
657315009196	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
657315009197	hexamer (dimer of trimers) interface [polypeptide binding]; other site
657315009198	trimer interface [polypeptide binding]; other site
657315009199	substrate binding site [chemical binding]; other site
657315009200	Mn binding site [ion binding]; other site
657315009201	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
657315009202	active site
657315009203	intersubunit interactions; other site
657315009204	catalytic residue [active]
657315009205	transketolase; Reviewed; Region: PRK05899
657315009206	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
657315009207	TPP-binding site [chemical binding]; other site
657315009208	dimer interface [polypeptide binding]; other site
657315009209	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
657315009210	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
657315009211	PYR/PP interface [polypeptide binding]; other site
657315009212	dimer interface [polypeptide binding]; other site
657315009213	TPP binding site [chemical binding]; other site
657315009214	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
657315009215	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
657315009216	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
657315009217	intersubunit interface [polypeptide binding]; other site
657315009218	active site
657315009219	Zn2+ binding site [ion binding]; other site
657315009220	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
657315009221	active site
657315009222	catalytic residues [active]
657315009223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315009224	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315009225	ATP binding site [chemical binding]; other site
657315009226	G-X-G motif; other site
657315009227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315009228	active site
657315009229	dimerization interface [polypeptide binding]; other site
657315009230	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
657315009231	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
657315009232	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
657315009233	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
657315009234	DNA binding residues [nucleotide binding]
657315009235	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315009236	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315009237	active site
657315009238	phosphorylation site [posttranslational modification]
657315009239	intermolecular recognition site; other site
657315009240	dimerization interface [polypeptide binding]; other site
657315009241	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315009242	DNA binding site [nucleotide binding]
657315009243	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315009244	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315009245	dimer interface [polypeptide binding]; other site
657315009246	phosphorylation site [posttranslational modification]
657315009247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315009248	ATP binding site [chemical binding]; other site
657315009249	Mg2+ binding site [ion binding]; other site
657315009250	G-X-G motif; other site
657315009251	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657315009252	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657315009253	Walker A/P-loop; other site
657315009254	ATP binding site [chemical binding]; other site
657315009255	Q-loop/lid; other site
657315009256	ABC transporter signature motif; other site
657315009257	Walker B; other site
657315009258	D-loop; other site
657315009259	H-loop/switch region; other site
657315009260	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657315009261	FtsX-like permease family; Region: FtsX; pfam02687
657315009262	FtsX-like permease family; Region: FtsX; pfam02687
657315009263	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
657315009264	MobA/MobL family; Region: MobA_MobL; pfam03389
657315009265	Helix-turn-helix domain; Region: HTH_17; cl17695
657315009266	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657315009267	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657315009268	non-specific DNA binding site [nucleotide binding]; other site
657315009269	salt bridge; other site
657315009270	sequence-specific DNA binding site [nucleotide binding]; other site
657315009271	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315009272	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
657315009273	Int/Topo IB signature motif; other site
657315009274	Domain of unknown function (DUF4176); Region: DUF4176; cl01867
657315009275	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
657315009276	Transposase IS200 like; Region: Y1_Tnp; pfam01797
657315009277	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315009278	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315009279	dimer interface [polypeptide binding]; other site
657315009280	phosphorylation site [posttranslational modification]
657315009281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315009282	ATP binding site [chemical binding]; other site
657315009283	Mg2+ binding site [ion binding]; other site
657315009284	G-X-G motif; other site
657315009285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315009286	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
657315009287	active site
657315009288	phosphorylation site [posttranslational modification]
657315009289	intermolecular recognition site; other site
657315009290	dimerization interface [polypeptide binding]; other site
657315009291	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315009292	DNA binding site [nucleotide binding]
657315009293	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
657315009294	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
657315009295	Walker A/P-loop; other site
657315009296	ATP binding site [chemical binding]; other site
657315009297	Q-loop/lid; other site
657315009298	ABC transporter signature motif; other site
657315009299	Walker B; other site
657315009300	D-loop; other site
657315009301	H-loop/switch region; other site
657315009302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
657315009303	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
657315009304	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
657315009305	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
657315009306	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
657315009307	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657315009308	Walker A motif; other site
657315009309	ATP binding site [chemical binding]; other site
657315009310	Walker B motif; other site
657315009311	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
657315009312	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
657315009313	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
657315009314	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
657315009315	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
657315009316	dimerization interface [polypeptide binding]; other site
657315009317	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
657315009318	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315009319	dimer interface [polypeptide binding]; other site
657315009320	putative CheW interface [polypeptide binding]; other site
657315009321	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
657315009322	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
657315009323	CHC2 zinc finger; Region: zf-CHC2; cl17510
657315009324	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
657315009325	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315009326	ATP binding site [chemical binding]; other site
657315009327	Mg2+ binding site [ion binding]; other site
657315009328	G-X-G motif; other site
657315009329	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657315009330	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315009331	active site
657315009332	phosphorylation site [posttranslational modification]
657315009333	intermolecular recognition site; other site
657315009334	dimerization interface [polypeptide binding]; other site
657315009335	LytTr DNA-binding domain; Region: LytTR; smart00850
657315009336	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
657315009337	intermolecular recognition site; other site
657315009338	active site
657315009339	dimerization interface [polypeptide binding]; other site
657315009340	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
657315009341	Uncharacterized conserved protein [Function unknown]; Region: COG5361
657315009342	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
657315009343	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
657315009344	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
657315009345	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
657315009346	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
657315009347	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657315009348	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657315009349	DNA binding residues [nucleotide binding]
657315009350	Beta propeller domain; Region: Beta_propel; pfam09826
657315009351	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
657315009352	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
657315009353	substrate binding pocket [chemical binding]; other site
657315009354	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
657315009355	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
657315009356	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
657315009357	active site
657315009358	HIGH motif; other site
657315009359	dimer interface [polypeptide binding]; other site
657315009360	KMSKS motif; other site
657315009361	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
657315009362	RNA binding surface [nucleotide binding]; other site
657315009363	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
657315009364	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657315009365	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657315009366	DNA binding residues [nucleotide binding]
657315009367	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
657315009368	MarR family; Region: MarR_2; pfam12802
657315009369	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315009370	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
657315009371	active site
657315009372	motif I; other site
657315009373	motif II; other site
657315009374	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657315009375	BioY family; Region: BioY; pfam02632
657315009376	biotin synthase; Region: bioB; TIGR00433
657315009377	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315009378	FeS/SAM binding site; other site
657315009379	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
657315009380	AAA domain; Region: AAA_26; pfam13500
657315009381	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
657315009382	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
657315009383	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
657315009384	inhibitor-cofactor binding pocket; inhibition site
657315009385	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657315009386	catalytic residue [active]
657315009387	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674
657315009388	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
657315009389	dimer interface [polypeptide binding]; other site
657315009390	PYR/PP interface [polypeptide binding]; other site
657315009391	TPP binding site [chemical binding]; other site
657315009392	substrate binding site [chemical binding]; other site
657315009393	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
657315009394	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
657315009395	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
657315009396	2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179
657315009397	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657315009398	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
657315009399	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
657315009400	transmembrane helices; other site
657315009401	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
657315009402	EamA-like transporter family; Region: EamA; pfam00892
657315009403	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
657315009404	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
657315009405	active site
657315009406	catalytic site [active]
657315009407	metal binding site [ion binding]; metal-binding site
657315009408	dimer interface [polypeptide binding]; other site
657315009409	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
657315009410	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
657315009411	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
657315009412	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657315009413	putative substrate translocation pore; other site
657315009414	polyphosphate kinase; Provisional; Region: PRK05443
657315009415	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
657315009416	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
657315009417	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
657315009418	putative active site [active]
657315009419	catalytic site [active]
657315009420	Catalytic C-terminal domain, second repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C2_unchar; cd09169
657315009421	putative domain interface [polypeptide binding]; other site
657315009422	putative active site [active]
657315009423	catalytic site [active]
657315009424	PBP superfamily domain; Region: PBP_like_2; cl17296
657315009425	PBP superfamily domain; Region: PBP_like_2; cl17296
657315009426	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
657315009427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315009428	dimer interface [polypeptide binding]; other site
657315009429	conserved gate region; other site
657315009430	putative PBP binding loops; other site
657315009431	ABC-ATPase subunit interface; other site
657315009432	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
657315009433	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657315009434	dimer interface [polypeptide binding]; other site
657315009435	conserved gate region; other site
657315009436	putative PBP binding loops; other site
657315009437	ABC-ATPase subunit interface; other site
657315009438	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
657315009439	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
657315009440	Walker A/P-loop; other site
657315009441	ATP binding site [chemical binding]; other site
657315009442	Q-loop/lid; other site
657315009443	ABC transporter signature motif; other site
657315009444	Walker B; other site
657315009445	D-loop; other site
657315009446	H-loop/switch region; other site
657315009447	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
657315009448	PhoU domain; Region: PhoU; pfam01895
657315009449	PhoU domain; Region: PhoU; pfam01895
657315009450	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
657315009451	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
657315009452	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
657315009453	PhoU domain; Region: PhoU; pfam01895
657315009454	PhoU domain; Region: PhoU; pfam01895
657315009455	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657315009456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315009457	active site
657315009458	phosphorylation site [posttranslational modification]
657315009459	intermolecular recognition site; other site
657315009460	dimerization interface [polypeptide binding]; other site
657315009461	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657315009462	DNA binding site [nucleotide binding]
657315009463	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315009464	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315009465	dimer interface [polypeptide binding]; other site
657315009466	phosphorylation site [posttranslational modification]
657315009467	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315009468	ATP binding site [chemical binding]; other site
657315009469	Mg2+ binding site [ion binding]; other site
657315009470	G-X-G motif; other site
657315009471	SWIM zinc finger; Region: SWIM; pfam04434
657315009472	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
657315009473	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
657315009474	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
657315009475	ATP binding site [chemical binding]; other site
657315009476	putative Mg++ binding site [ion binding]; other site
657315009477	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
657315009478	nucleotide binding region [chemical binding]; other site
657315009479	ATP-binding site [chemical binding]; other site
657315009480	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
657315009481	Domain of unknown function DUF; Region: DUF204; pfam02659
657315009482	Domain of unknown function DUF; Region: DUF204; pfam02659
657315009483	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
657315009484	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
657315009485	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
657315009486	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
657315009487	active site
657315009488	catalytic residues [active]
657315009489	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
657315009490	Double zinc ribbon; Region: DZR; pfam12773
657315009491	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
657315009492	active site
657315009493	catalytic triad [active]
657315009494	oxyanion hole [active]
657315009495	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
657315009496	glycerol kinase; Provisional; Region: glpK; PRK00047
657315009497	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
657315009498	N- and C-terminal domain interface [polypeptide binding]; other site
657315009499	active site
657315009500	MgATP binding site [chemical binding]; other site
657315009501	catalytic site [active]
657315009502	metal binding site [ion binding]; metal-binding site
657315009503	glycerol binding site [chemical binding]; other site
657315009504	homotetramer interface [polypeptide binding]; other site
657315009505	homodimer interface [polypeptide binding]; other site
657315009506	FBP binding site [chemical binding]; other site
657315009507	protein IIAGlc interface [polypeptide binding]; other site
657315009508	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
657315009509	amphipathic channel; other site
657315009510	Asn-Pro-Ala signature motifs; other site
657315009511	Predicted dehydrogenase [General function prediction only]; Region: COG0579
657315009512	hydroxyglutarate oxidase; Provisional; Region: PRK11728
657315009513	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
657315009514	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
657315009515	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
657315009516	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
657315009517	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
657315009518	Protein of unknown function (DUF1667); Region: DUF1667; pfam07892
657315009519	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
657315009520	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
657315009521	active site
657315009522	HIGH motif; other site
657315009523	KMSKS motif; other site
657315009524	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
657315009525	tRNA binding surface [nucleotide binding]; other site
657315009526	anticodon binding site; other site
657315009527	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
657315009528	dimer interface [polypeptide binding]; other site
657315009529	putative tRNA-binding site [nucleotide binding]; other site
657315009530	phosphodiesterase; Provisional; Region: PRK12704
657315009531	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
657315009532	active site
657315009533	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
657315009534	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
657315009535	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
657315009536	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657315009537	FeS/SAM binding site; other site
657315009538	Cache domain; Region: Cache_1; pfam02743
657315009539	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
657315009540	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
657315009541	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
657315009542	dimer interface [polypeptide binding]; other site
657315009543	putative CheW interface [polypeptide binding]; other site
657315009544	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
657315009545	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657315009546	S-adenosylmethionine binding site [chemical binding]; other site
657315009547	stage II sporulation protein D; Region: spore_II_D; TIGR02870
657315009548	Stage II sporulation protein; Region: SpoIID; pfam08486
657315009549	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
657315009550	Peptidase family M23; Region: Peptidase_M23; pfam01551
657315009551	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657315009552	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657315009553	metal binding site [ion binding]; metal-binding site
657315009554	active site
657315009555	I-site; other site
657315009556	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
657315009557	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
657315009558	ATP binding site [chemical binding]; other site
657315009559	Mg++ binding site [ion binding]; other site
657315009560	motif III; other site
657315009561	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
657315009562	nucleotide binding region [chemical binding]; other site
657315009563	ATP-binding site [chemical binding]; other site
657315009564	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
657315009565	RNA binding site [nucleotide binding]; other site
657315009566	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144
657315009567	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315009568	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
657315009569	Rubredoxin; Region: Rubredoxin; pfam00301
657315009570	iron binding site [ion binding]; other site
657315009571	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
657315009572	Rubrerythrin [Energy production and conversion]; Region: COG1592
657315009573	diiron binding motif [ion binding]; other site
657315009574	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
657315009575	metal binding site 2 [ion binding]; metal-binding site
657315009576	putative DNA binding helix; other site
657315009577	metal binding site 1 [ion binding]; metal-binding site
657315009578	dimer interface [polypeptide binding]; other site
657315009579	structural Zn2+ binding site [ion binding]; other site
657315009580	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
657315009581	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
657315009582	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
657315009583	nucleoside/Zn binding site; other site
657315009584	dimer interface [polypeptide binding]; other site
657315009585	catalytic motif [active]
657315009586	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
657315009587	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315009588	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
657315009589	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
657315009590	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
657315009591	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
657315009592	transmembrane helices; other site
657315009593	6-phosphofructokinase; Provisional; Region: PRK03202
657315009594	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
657315009595	active site
657315009596	ADP/pyrophosphate binding site [chemical binding]; other site
657315009597	dimerization interface [polypeptide binding]; other site
657315009598	allosteric effector site; other site
657315009599	fructose-1,6-bisphosphate binding site; other site
657315009600	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
657315009601	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657315009602	Walker A motif; other site
657315009603	ATP binding site [chemical binding]; other site
657315009604	Walker B motif; other site
657315009605	arginine finger; other site
657315009606	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
657315009607	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
657315009608	hypothetical protein; Validated; Region: PRK00153
657315009609	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657315009610	active site
657315009611	DNA binding site [nucleotide binding]
657315009612	Int/Topo IB signature motif; other site
657315009613	Global regulator protein family; Region: CsrA; pfam02599
657315009614	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
657315009615	flagellin; Validated; Region: PRK08026
657315009616	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
657315009617	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
657315009618	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
657315009619	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
657315009620	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
657315009621	catalytic core [active]
657315009622	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
657315009623	active site
657315009624	catalytic site [active]
657315009625	substrate binding site [chemical binding]; other site
657315009626	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
657315009627	Acylphosphatase; Region: Acylphosphatase; pfam00708
657315009628	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657315009629	Helix-turn-helix domain; Region: HTH_18; pfam12833
657315009630	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
657315009631	MFS/sugar transport protein; Region: MFS_2; pfam13347
657315009632	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
657315009633	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
657315009634	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
657315009635	Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545
657315009636	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
657315009637	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657315009638	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657315009639	dimer interface [polypeptide binding]; other site
657315009640	phosphorylation site [posttranslational modification]
657315009641	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657315009642	ATP binding site [chemical binding]; other site
657315009643	Mg2+ binding site [ion binding]; other site
657315009644	G-X-G motif; other site
657315009645	Response regulator receiver domain; Region: Response_reg; pfam00072
657315009646	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657315009647	active site
657315009648	phosphorylation site [posttranslational modification]
657315009649	intermolecular recognition site; other site
657315009650	dimerization interface [polypeptide binding]; other site
657315009651	Uncharacterized conserved protein [Function unknown]; Region: COG1284
657315009652	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
657315009653	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
657315009654	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
657315009655	substrate binding site; other site
657315009656	dimerization interface; other site
657315009657	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
657315009658	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
657315009659	synthetase active site [active]
657315009660	NTP binding site [chemical binding]; other site
657315009661	metal binding site [ion binding]; metal-binding site
657315009662	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
657315009663	putative catalytic site [active]
657315009664	putative phosphate binding site [ion binding]; other site
657315009665	putative metal binding site [ion binding]; other site
657315009666	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
657315009667	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
657315009668	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
657315009669	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657315009670	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
657315009671	C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156
657315009672	putative homodimer interface [polypeptide binding]; other site
657315009673	putative homotetramer interface [polypeptide binding]; other site
657315009674	putative allosteric switch controlling residues; other site
657315009675	putative metal binding site [ion binding]; other site
657315009676	putative homodimer-homodimer interface [polypeptide binding]; other site
657315009677	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
657315009678	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
657315009679	metal-binding site [ion binding]
657315009680	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
657315009681	Soluble P-type ATPase [General function prediction only]; Region: COG4087
657315009682	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
657315009683	metal-binding site [ion binding]
657315009684	recombination protein RecR; Reviewed; Region: recR; PRK00076
657315009685	RecR protein; Region: RecR; pfam02132
657315009686	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
657315009687	putative active site [active]
657315009688	putative metal-binding site [ion binding]; other site
657315009689	tetramer interface [polypeptide binding]; other site
657315009690	transketolase; Reviewed; Region: PRK05899
657315009691	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
657315009692	TPP-binding site [chemical binding]; other site
657315009693	dimer interface [polypeptide binding]; other site
657315009694	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
657315009695	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
657315009696	PYR/PP interface [polypeptide binding]; other site
657315009697	dimer interface [polypeptide binding]; other site
657315009698	TPP binding site [chemical binding]; other site
657315009699	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
657315009700	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
657315009701	Colicin V production protein; Region: Colicin_V; pfam02674