-- dump date 20140620_040849 -- class Genbank::misc_feature -- table misc_feature_note -- id note 357808000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 357808000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 357808000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808000004 Walker A motif; other site 357808000005 ATP binding site [chemical binding]; other site 357808000006 Walker B motif; other site 357808000007 arginine finger; other site 357808000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 357808000009 DnaA box-binding interface [nucleotide binding]; other site 357808000010 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 357808000011 intersubunit interface [polypeptide binding]; other site 357808000012 active site 357808000013 Zn2+ binding site [ion binding]; other site 357808000014 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 357808000015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808000016 NAD(P) binding site [chemical binding]; other site 357808000017 active site 357808000018 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 357808000019 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 357808000020 ferredoxin-NADP+ reductase; Region: PLN02852 357808000021 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357808000022 conserved hypothetical protein; Region: TIGR03843 357808000023 conserved hypothetical protein; Region: TIGR03847 357808000024 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357808000025 catalytic core [active] 357808000026 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 357808000027 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 357808000028 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 357808000029 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 357808000030 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 357808000031 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 357808000032 putative acyl-acceptor binding pocket; other site 357808000033 DNA photolyase; Region: DNA_photolyase; pfam00875 357808000034 trehalose synthase; Region: treS_nterm; TIGR02456 357808000035 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 357808000036 Ca binding site [ion binding]; other site 357808000037 active site 357808000038 catalytic site [active] 357808000039 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 357808000040 short chain dehydrogenase; Provisional; Region: PRK06197 357808000041 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 357808000042 putative NAD(P) binding site [chemical binding]; other site 357808000043 active site 357808000044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357808000045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357808000046 WHG domain; Region: WHG; pfam13305 357808000047 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 357808000048 toxin interface [polypeptide binding]; other site 357808000049 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 357808000050 Zn binding site [ion binding]; other site 357808000051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357808000052 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 357808000053 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 357808000054 acyl-activating enzyme (AAE) consensus motif; other site 357808000055 putative AMP binding site [chemical binding]; other site 357808000056 putative active site [active] 357808000057 putative CoA binding site [chemical binding]; other site 357808000058 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357808000059 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 357808000060 substrate binding site [chemical binding]; other site 357808000061 oxyanion hole (OAH) forming residues; other site 357808000062 trimer interface [polypeptide binding]; other site 357808000063 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 357808000064 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 357808000065 dimer interface [polypeptide binding]; other site 357808000066 tetramer interface [polypeptide binding]; other site 357808000067 PYR/PP interface [polypeptide binding]; other site 357808000068 TPP binding site [chemical binding]; other site 357808000069 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357808000070 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 357808000071 TPP-binding site; other site 357808000072 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 357808000073 chorismate binding enzyme; Region: Chorismate_bind; cl10555 357808000074 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357808000075 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357808000076 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 357808000077 anti sigma factor interaction site; other site 357808000078 regulatory phosphorylation site [posttranslational modification]; other site 357808000079 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 357808000080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808000081 ATP binding site [chemical binding]; other site 357808000082 Mg2+ binding site [ion binding]; other site 357808000083 G-X-G motif; other site 357808000084 TPR repeat; Region: TPR_11; pfam13414 357808000085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808000086 binding surface 357808000087 TPR motif; other site 357808000088 TPR repeat; Region: TPR_11; pfam13414 357808000089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808000090 binding surface 357808000091 TPR motif; other site 357808000092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808000093 binding surface 357808000094 TPR motif; other site 357808000095 TPR repeat; Region: TPR_11; pfam13414 357808000096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808000097 binding surface 357808000098 TPR motif; other site 357808000099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808000100 binding surface 357808000101 TPR repeat; Region: TPR_11; pfam13414 357808000102 TPR motif; other site 357808000103 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 357808000104 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 357808000105 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 357808000106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808000107 S-adenosylmethionine binding site [chemical binding]; other site 357808000108 TPR repeat; Region: TPR_11; pfam13414 357808000109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808000110 binding surface 357808000111 TPR motif; other site 357808000112 TPR repeat; Region: TPR_11; pfam13414 357808000113 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 357808000114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808000115 active site 357808000116 phosphorylation site [posttranslational modification] 357808000117 intermolecular recognition site; other site 357808000118 dimerization interface [polypeptide binding]; other site 357808000119 CheB methylesterase; Region: CheB_methylest; pfam01339 357808000120 Response regulator receiver domain; Region: Response_reg; pfam00072 357808000121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808000122 active site 357808000123 phosphorylation site [posttranslational modification] 357808000124 intermolecular recognition site; other site 357808000125 dimerization interface [polypeptide binding]; other site 357808000126 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 357808000127 putative binding surface; other site 357808000128 active site 357808000129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808000130 ATP binding site [chemical binding]; other site 357808000131 Mg2+ binding site [ion binding]; other site 357808000132 G-X-G motif; other site 357808000133 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 357808000134 Response regulator receiver domain; Region: Response_reg; pfam00072 357808000135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808000136 active site 357808000137 phosphorylation site [posttranslational modification] 357808000138 intermolecular recognition site; other site 357808000139 dimerization interface [polypeptide binding]; other site 357808000140 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357808000141 dimer interface [polypeptide binding]; other site 357808000142 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 357808000143 putative CheW interface [polypeptide binding]; other site 357808000144 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 357808000145 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 357808000146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808000147 Walker A/P-loop; other site 357808000148 ATP binding site [chemical binding]; other site 357808000149 Q-loop/lid; other site 357808000150 ABC transporter signature motif; other site 357808000151 Walker B; other site 357808000152 D-loop; other site 357808000153 H-loop/switch region; other site 357808000154 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 357808000155 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357808000156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808000157 Walker A/P-loop; other site 357808000158 ATP binding site [chemical binding]; other site 357808000159 Q-loop/lid; other site 357808000160 ABC transporter signature motif; other site 357808000161 Walker B; other site 357808000162 D-loop; other site 357808000163 H-loop/switch region; other site 357808000164 Protein of unknown function (DUF454); Region: DUF454; pfam04304 357808000165 adenylosuccinate lyase; Provisional; Region: PRK09285 357808000166 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 357808000167 tetramer interface [polypeptide binding]; other site 357808000168 active site 357808000169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 357808000170 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808000171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357808000172 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 357808000173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808000174 ATP binding site [chemical binding]; other site 357808000175 Mg2+ binding site [ion binding]; other site 357808000176 G-X-G motif; other site 357808000177 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 357808000178 anchoring element; other site 357808000179 dimer interface [polypeptide binding]; other site 357808000180 ATP binding site [chemical binding]; other site 357808000181 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 357808000182 active site 357808000183 putative metal-binding site [ion binding]; other site 357808000184 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 357808000185 Isochorismatase family; Region: Isochorismatase; pfam00857 357808000186 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 357808000187 catalytic triad [active] 357808000188 substrate binding site [chemical binding]; other site 357808000189 domain interfaces; other site 357808000190 conserved cis-peptide bond; other site 357808000191 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 357808000192 active site 357808000193 catalytic residues [active] 357808000194 metal binding site [ion binding]; metal-binding site 357808000195 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 357808000196 CoA-transferase family III; Region: CoA_transf_3; pfam02515 357808000197 Transcriptional regulators [Transcription]; Region: FadR; COG2186 357808000198 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357808000199 DNA-binding site [nucleotide binding]; DNA binding site 357808000200 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 357808000201 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 357808000202 Peptidase family M23; Region: Peptidase_M23; pfam01551 357808000203 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808000204 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 357808000205 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 357808000206 AAA domain; Region: AAA_11; pfam13086 357808000207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808000208 Walker A motif; other site 357808000209 ATP binding site [chemical binding]; other site 357808000210 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 357808000211 AAA domain; Region: AAA_12; pfam13087 357808000212 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 357808000213 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 357808000214 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 357808000215 DNA binding residues [nucleotide binding] 357808000216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357808000217 non-specific DNA binding site [nucleotide binding]; other site 357808000218 salt bridge; other site 357808000219 sequence-specific DNA binding site [nucleotide binding]; other site 357808000220 Domain of unknown function (DUF955); Region: DUF955; pfam06114 357808000221 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 357808000222 Family description; Region: UvrD_C_2; pfam13538 357808000223 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357808000224 DNA binding site [nucleotide binding] 357808000225 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 357808000226 Bacterial transcriptional activator domain; Region: BTAD; smart01043 357808000227 Predicted ATPase [General function prediction only]; Region: COG3899 357808000228 AAA ATPase domain; Region: AAA_16; pfam13191 357808000229 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 357808000230 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 357808000231 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 357808000232 substrate binding pocket [chemical binding]; other site 357808000233 dimer interface [polypeptide binding]; other site 357808000234 inhibitor binding site; inhibition site 357808000235 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 357808000236 B12 binding site [chemical binding]; other site 357808000237 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 357808000238 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 357808000239 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 357808000240 active site 357808000241 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808000242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808000243 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808000244 Uncharacterized conserved protein [Function unknown]; Region: COG2445 357808000245 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808000246 active site 357808000247 NTP binding site [chemical binding]; other site 357808000248 metal binding triad [ion binding]; metal-binding site 357808000249 antibiotic binding site [chemical binding]; other site 357808000250 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 357808000251 HIT family signature motif; other site 357808000252 catalytic residue [active] 357808000253 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 357808000254 hypothetical protein; Provisional; Region: PRK08609 357808000255 active site 357808000256 primer binding site [nucleotide binding]; other site 357808000257 NTP binding site [chemical binding]; other site 357808000258 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 357808000259 active site 357808000260 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 357808000261 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 357808000262 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 357808000263 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 357808000264 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 357808000265 dimer interface [polypeptide binding]; other site 357808000266 putative anticodon binding site; other site 357808000267 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 357808000268 motif 1; other site 357808000269 active site 357808000270 motif 2; other site 357808000271 motif 3; other site 357808000272 Fic/DOC family; Region: Fic; cl00960 357808000273 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357808000274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808000275 NAD(P) binding site [chemical binding]; other site 357808000276 active site 357808000277 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 357808000278 putative acyl-acceptor binding pocket; other site 357808000279 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808000280 active site 357808000281 NTP binding site [chemical binding]; other site 357808000282 metal binding triad [ion binding]; metal-binding site 357808000283 antibiotic binding site [chemical binding]; other site 357808000284 HEPN domain; Region: HEPN; pfam05168 357808000285 HEPN domain; Region: HEPN; pfam05168 357808000286 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808000287 active site 357808000288 NTP binding site [chemical binding]; other site 357808000289 metal binding triad [ion binding]; metal-binding site 357808000290 antibiotic binding site [chemical binding]; other site 357808000291 hypothetical protein; Provisional; Region: PRK07233 357808000292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357808000293 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 357808000294 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 357808000295 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808000296 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808000297 DNA binding residues [nucleotide binding] 357808000298 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 357808000299 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 357808000300 active site 357808000301 PHP Thumb interface [polypeptide binding]; other site 357808000302 metal binding site [ion binding]; metal-binding site 357808000303 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 357808000304 generic binding surface II; other site 357808000305 generic binding surface I; other site 357808000306 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808000307 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 357808000308 peptide binding site [polypeptide binding]; other site 357808000309 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 357808000310 dimer interface [polypeptide binding]; other site 357808000311 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 357808000312 hypothetical protein; Provisional; Region: PRK06446 357808000313 metal binding site [ion binding]; metal-binding site 357808000314 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 357808000315 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 357808000316 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 357808000317 dimer interface [polypeptide binding]; other site 357808000318 putative functional site; other site 357808000319 putative MPT binding site; other site 357808000320 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 357808000321 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357808000322 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357808000323 Lamin Tail Domain; Region: LTD; pfam00932 357808000324 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 357808000325 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 357808000326 nucleotide binding site [chemical binding]; other site 357808000327 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 357808000328 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 357808000329 putative GEF interaction site [polypeptide binding]; other site 357808000330 G1 box; other site 357808000331 GTP/Mg2+ binding site [chemical binding]; other site 357808000332 Switch I region; other site 357808000333 G2 box; other site 357808000334 G3 box; other site 357808000335 Switch II region; other site 357808000336 G4 box; other site 357808000337 G5 box; other site 357808000338 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 357808000339 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 357808000340 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808000341 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808000342 Acyl CoA binding protein; Region: ACBP; pfam00887 357808000343 acyl-CoA binding pocket [chemical binding]; other site 357808000344 CoA binding site [chemical binding]; other site 357808000345 Asparaginase [Amino acid transport and metabolism]; Region: COG1446 357808000346 active site 357808000347 dimer interface [polypeptide binding]; other site 357808000348 catalytic nucleophile [active] 357808000349 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 357808000350 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 357808000351 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 357808000352 competence damage-inducible protein A; Provisional; Region: PRK00549 357808000353 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 357808000354 putative MPT binding site; other site 357808000355 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 357808000356 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 357808000357 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 357808000358 active site 357808000359 dimer interface [polypeptide binding]; other site 357808000360 motif 1; other site 357808000361 motif 2; other site 357808000362 motif 3; other site 357808000363 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 357808000364 anticodon binding site; other site 357808000365 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 357808000366 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 357808000367 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 357808000368 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 357808000369 Na binding site [ion binding]; other site 357808000370 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808000371 dimerization interface [polypeptide binding]; other site 357808000372 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808000373 dimer interface [polypeptide binding]; other site 357808000374 phosphorylation site [posttranslational modification] 357808000375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808000376 ATP binding site [chemical binding]; other site 357808000377 Mg2+ binding site [ion binding]; other site 357808000378 G-X-G motif; other site 357808000379 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808000380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808000381 active site 357808000382 phosphorylation site [posttranslational modification] 357808000383 intermolecular recognition site; other site 357808000384 dimerization interface [polypeptide binding]; other site 357808000385 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808000386 DNA binding site [nucleotide binding] 357808000387 Bifunctional nuclease; Region: DNase-RNase; pfam02577 357808000388 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 357808000389 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357808000390 P-loop; other site 357808000391 Magnesium ion binding site [ion binding]; other site 357808000392 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357808000393 Magnesium ion binding site [ion binding]; other site 357808000394 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357808000395 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 357808000396 ParB-like nuclease domain; Region: ParBc; pfam02195 357808000397 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 357808000398 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 357808000399 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 357808000400 Walker A/P-loop; other site 357808000401 ATP binding site [chemical binding]; other site 357808000402 Q-loop/lid; other site 357808000403 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 357808000404 ABC transporter signature motif; other site 357808000405 Walker B; other site 357808000406 D-loop; other site 357808000407 H-loop/switch region; other site 357808000408 O-Antigen ligase; Region: Wzy_C; cl04850 357808000409 O-Antigen ligase; Region: Wzy_C; cl04850 357808000410 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 357808000411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808000412 TPR motif; other site 357808000413 TPR repeat; Region: TPR_11; pfam13414 357808000414 binding surface 357808000415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808000416 binding surface 357808000417 TPR motif; other site 357808000418 Tetratricopeptide repeat; Region: TPR_16; pfam13432 357808000419 Membrane transport protein; Region: Mem_trans; cl09117 357808000420 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 357808000421 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 357808000422 DctM-like transporters; Region: DctM; pfam06808 357808000423 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 357808000424 DNA methylase; Region: N6_N4_Mtase; pfam01555 357808000425 Winged helix-turn helix; Region: HTH_29; pfam13551 357808000426 Homeodomain-like domain; Region: HTH_32; pfam13565 357808000427 Winged helix-turn helix; Region: HTH_33; pfam13592 357808000428 DDE superfamily endonuclease; Region: DDE_3; pfam13358 357808000429 Caspase domain; Region: Peptidase_C14; pfam00656 357808000430 AAA ATPase domain; Region: AAA_16; pfam13191 357808000431 NACHT domain; Region: NACHT; pfam05729 357808000432 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 357808000433 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357808000434 active site 357808000435 HIGH motif; other site 357808000436 nucleotide binding site [chemical binding]; other site 357808000437 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 357808000438 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 357808000439 active site 357808000440 KMSKS motif; other site 357808000441 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 357808000442 tRNA binding surface [nucleotide binding]; other site 357808000443 anticodon binding site; other site 357808000444 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 357808000445 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357808000446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808000447 NAD(P) binding site [chemical binding]; other site 357808000448 active site 357808000449 Transcriptional regulator [Transcription]; Region: LytR; COG1316 357808000450 integral membrane protein MviN; Region: mviN; TIGR01695 357808000451 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 357808000452 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808000453 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 357808000454 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 357808000455 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357808000456 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 357808000457 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 357808000458 active site 357808000459 catalytic site [active] 357808000460 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 357808000461 substrate binding pocket [chemical binding]; other site 357808000462 substrate-Mg2+ binding site; other site 357808000463 aspartate-rich region 1; other site 357808000464 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 357808000465 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 357808000466 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 357808000467 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 357808000468 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 357808000469 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 357808000470 Part of AAA domain; Region: AAA_19; pfam13245 357808000471 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 357808000472 ADP-ribose binding site [chemical binding]; other site 357808000473 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 357808000474 catalytic triad [active] 357808000475 conserved cis-peptide bond; other site 357808000476 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 357808000477 nudix motif; other site 357808000478 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 357808000479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808000480 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 357808000481 FeS/SAM binding site; other site 357808000482 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 357808000483 AAA ATPase domain; Region: AAA_16; pfam13191 357808000484 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808000485 orc1/cdc6 family replication initiation protein; Region: TIGR02928 357808000486 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 357808000487 G1 box; other site 357808000488 GTP/Mg2+ binding site [chemical binding]; other site 357808000489 G2 box; other site 357808000490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 357808000491 DNA binding site [nucleotide binding] 357808000492 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808000493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808000494 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808000495 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808000496 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808000497 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 357808000498 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 357808000499 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 357808000500 Peptidase M16C associated; Region: M16C_assoc; pfam08367 357808000501 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 357808000502 NAD-dependent deacetylase; Provisional; Region: PRK00481 357808000503 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 357808000504 Pleckstrin homology-like domain; Region: PH-like; cl17171 357808000505 Response regulator receiver domain; Region: Response_reg; pfam00072 357808000506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808000507 active site 357808000508 phosphorylation site [posttranslational modification] 357808000509 intermolecular recognition site; other site 357808000510 dimerization interface [polypeptide binding]; other site 357808000511 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 357808000512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808000513 ATP binding site [chemical binding]; other site 357808000514 Mg2+ binding site [ion binding]; other site 357808000515 G-X-G motif; other site 357808000516 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808000517 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 357808000518 nudix motif; other site 357808000519 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 357808000520 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 357808000521 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 357808000522 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 357808000523 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357808000524 catalytic residue [active] 357808000525 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357808000526 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 357808000527 Walker A/P-loop; other site 357808000528 ATP binding site [chemical binding]; other site 357808000529 Q-loop/lid; other site 357808000530 ABC transporter signature motif; other site 357808000531 Walker B; other site 357808000532 D-loop; other site 357808000533 H-loop/switch region; other site 357808000534 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 357808000535 Protein of unknown function (DUF3680); Region: DUF3680; pfam12441 357808000536 Protein of unknown function (DUF497); Region: DUF497; cl01108 357808000537 cobalt transport protein CbiM; Validated; Region: PRK06265 357808000538 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 357808000539 PDGLE domain; Region: PDGLE; cl07986 357808000540 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 357808000541 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 357808000542 tetramer interface [polypeptide binding]; other site 357808000543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808000544 catalytic residue [active] 357808000545 H+ Antiporter protein; Region: 2A0121; TIGR00900 357808000546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808000547 putative substrate translocation pore; other site 357808000548 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357808000549 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 357808000550 HlyD family secretion protein; Region: HlyD_3; pfam13437 357808000551 FtsX-like permease family; Region: FtsX; pfam02687 357808000552 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357808000553 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357808000554 Walker A/P-loop; other site 357808000555 ATP binding site [chemical binding]; other site 357808000556 Q-loop/lid; other site 357808000557 ABC transporter signature motif; other site 357808000558 Walker B; other site 357808000559 D-loop; other site 357808000560 H-loop/switch region; other site 357808000561 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 357808000562 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357808000563 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357808000564 Walker A/P-loop; other site 357808000565 ATP binding site [chemical binding]; other site 357808000566 Q-loop/lid; other site 357808000567 ABC transporter signature motif; other site 357808000568 Walker B; other site 357808000569 D-loop; other site 357808000570 H-loop/switch region; other site 357808000571 AAA domain; Region: AAA_14; pfam13173 357808000572 AAA domain; Region: AAA_22; pfam13401 357808000573 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 357808000574 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 357808000575 putative active site [active] 357808000576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808000577 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 357808000578 Walker A motif; other site 357808000579 ATP binding site [chemical binding]; other site 357808000580 Walker B motif; other site 357808000581 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 357808000582 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808000583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808000584 active site 357808000585 phosphorylation site [posttranslational modification] 357808000586 intermolecular recognition site; other site 357808000587 dimerization interface [polypeptide binding]; other site 357808000588 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808000589 DNA binding site [nucleotide binding] 357808000590 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 357808000591 SmpB-tmRNA interface; other site 357808000592 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 357808000593 active site 357808000594 dimer interface [polypeptide binding]; other site 357808000595 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 357808000596 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 357808000597 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 357808000598 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808000599 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357808000600 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808000601 DNA binding residues [nucleotide binding] 357808000602 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 357808000603 aromatic arch; other site 357808000604 DCoH dimer interaction site [polypeptide binding]; other site 357808000605 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 357808000606 DCoH tetramer interaction site [polypeptide binding]; other site 357808000607 substrate binding site [chemical binding]; other site 357808000608 ScpA/B protein; Region: ScpA_ScpB; cl00598 357808000609 ScpA/B protein; Region: ScpA_ScpB; cl00598 357808000610 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808000611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808000612 active site 357808000613 phosphorylation site [posttranslational modification] 357808000614 intermolecular recognition site; other site 357808000615 dimerization interface [polypeptide binding]; other site 357808000616 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808000617 DNA binding site [nucleotide binding] 357808000618 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808000619 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808000620 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357808000621 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808000622 putative active site [active] 357808000623 heme pocket [chemical binding]; other site 357808000624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808000625 dimer interface [polypeptide binding]; other site 357808000626 phosphorylation site [posttranslational modification] 357808000627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808000628 ATP binding site [chemical binding]; other site 357808000629 Mg2+ binding site [ion binding]; other site 357808000630 G-X-G motif; other site 357808000631 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 357808000632 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 357808000633 putative dimer interface [polypeptide binding]; other site 357808000634 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 357808000635 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 357808000636 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 357808000637 G1 box; other site 357808000638 GTP/Mg2+ binding site [chemical binding]; other site 357808000639 G2 box; other site 357808000640 Switch I region; other site 357808000641 G3 box; other site 357808000642 Switch II region; other site 357808000643 G4 box; other site 357808000644 G5 box; other site 357808000645 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 357808000646 MarR family; Region: MarR_2; cl17246 357808000647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808000648 dimer interface [polypeptide binding]; other site 357808000649 phosphorylation site [posttranslational modification] 357808000650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808000651 ATP binding site [chemical binding]; other site 357808000652 Mg2+ binding site [ion binding]; other site 357808000653 G-X-G motif; other site 357808000654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808000655 active site 357808000656 phosphorylation site [posttranslational modification] 357808000657 intermolecular recognition site; other site 357808000658 dimerization interface [polypeptide binding]; other site 357808000659 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357808000660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808000661 active site 357808000662 phosphorylation site [posttranslational modification] 357808000663 intermolecular recognition site; other site 357808000664 dimerization interface [polypeptide binding]; other site 357808000665 Response regulator receiver domain; Region: Response_reg; pfam00072 357808000666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808000667 active site 357808000668 phosphorylation site [posttranslational modification] 357808000669 intermolecular recognition site; other site 357808000670 dimerization interface [polypeptide binding]; other site 357808000671 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 357808000672 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 357808000673 purine monophosphate binding site [chemical binding]; other site 357808000674 dimer interface [polypeptide binding]; other site 357808000675 putative catalytic residues [active] 357808000676 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 357808000677 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 357808000678 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 357808000679 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 357808000680 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 357808000681 metal binding site [ion binding]; metal-binding site 357808000682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808000683 dimer interface [polypeptide binding]; other site 357808000684 phosphorylation site [posttranslational modification] 357808000685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808000686 ATP binding site [chemical binding]; other site 357808000687 Mg2+ binding site [ion binding]; other site 357808000688 G-X-G motif; other site 357808000689 YGGT family; Region: YGGT; pfam02325 357808000690 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 357808000691 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 357808000692 hinge; other site 357808000693 active site 357808000694 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 357808000695 glyoxylate reductase; Reviewed; Region: PRK13243 357808000696 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 357808000697 dimerization interface [polypeptide binding]; other site 357808000698 ligand binding site [chemical binding]; other site 357808000699 NADP binding site [chemical binding]; other site 357808000700 catalytic site [active] 357808000701 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808000702 putative active site [active] 357808000703 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 357808000704 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 357808000705 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 357808000706 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 357808000707 Potassium binding sites [ion binding]; other site 357808000708 Cesium cation binding sites [ion binding]; other site 357808000709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808000710 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 357808000711 NAD(P) binding site [chemical binding]; other site 357808000712 active site 357808000713 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808000714 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 357808000715 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 357808000716 active site 357808000717 substrate binding site [chemical binding]; other site 357808000718 metal binding site [ion binding]; metal-binding site 357808000719 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 357808000720 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808000721 ATP binding site [chemical binding]; other site 357808000722 putative Mg++ binding site [ion binding]; other site 357808000723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808000724 ATP-binding site [chemical binding]; other site 357808000725 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 357808000726 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 357808000727 UbiA prenyltransferase family; Region: UbiA; pfam01040 357808000728 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357808000729 PGAP1-like protein; Region: PGAP1; pfam07819 357808000730 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 357808000731 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357808000732 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357808000733 Family description; Region: ACT_7; pfam13840 357808000734 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 357808000735 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 357808000736 acyl-activating enzyme (AAE) consensus motif; other site 357808000737 putative AMP binding site [chemical binding]; other site 357808000738 putative active site [active] 357808000739 putative CoA binding site [chemical binding]; other site 357808000740 Beta-lactamase; Region: Beta-lactamase; pfam00144 357808000741 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357808000742 PAS fold; Region: PAS_4; pfam08448 357808000743 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808000744 GAF domain; Region: GAF_3; pfam13492 357808000745 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808000746 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808000747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808000748 dimer interface [polypeptide binding]; other site 357808000749 phosphorylation site [posttranslational modification] 357808000750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808000751 ATP binding site [chemical binding]; other site 357808000752 G-X-G motif; other site 357808000753 Response regulator receiver domain; Region: Response_reg; pfam00072 357808000754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808000755 active site 357808000756 phosphorylation site [posttranslational modification] 357808000757 intermolecular recognition site; other site 357808000758 dimerization interface [polypeptide binding]; other site 357808000759 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 357808000760 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 357808000761 Dimer interface [polypeptide binding]; other site 357808000762 anticodon binding site; other site 357808000763 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 357808000764 homodimer interface [polypeptide binding]; other site 357808000765 motif 1; other site 357808000766 motif 2; other site 357808000767 active site 357808000768 motif 3; other site 357808000769 DNA adenine methylase (dam); Region: dam; TIGR00571 357808000770 aconitate hydratase; Validated; Region: PRK09277 357808000771 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 357808000772 substrate binding site [chemical binding]; other site 357808000773 ligand binding site [chemical binding]; other site 357808000774 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 357808000775 substrate binding site [chemical binding]; other site 357808000776 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357808000777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357808000778 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 357808000779 putative dimerization interface [polypeptide binding]; other site 357808000780 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 357808000781 Protein of unknown function (DUF499); Region: DUF499; pfam04465 357808000782 GxxExxY protein; Region: GxxExxY; TIGR04256 357808000783 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 357808000784 Methyltransferase domain; Region: Methyltransf_26; pfam13659 357808000785 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 357808000786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357808000787 DEAD-like helicases superfamily; Region: DEXDc; smart00487 357808000788 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808000789 ATP binding site [chemical binding]; other site 357808000790 putative Mg++ binding site [ion binding]; other site 357808000791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808000792 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 357808000793 nucleotide binding region [chemical binding]; other site 357808000794 ATP-binding site [chemical binding]; other site 357808000795 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 357808000796 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357808000797 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 357808000798 TIGR03663 family protein; Region: TIGR03663 357808000799 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 357808000800 NHL repeat; Region: NHL; pfam01436 357808000801 Uncharacterized conserved protein [Function unknown]; Region: COG3391 357808000802 NHL repeat; Region: NHL; pfam01436 357808000803 NHL repeat; Region: NHL; pfam01436 357808000804 NHL repeat; Region: NHL; pfam01436 357808000805 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 357808000806 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357808000807 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357808000808 ligand binding site [chemical binding]; other site 357808000809 flexible hinge region; other site 357808000810 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 357808000811 putative switch regulator; other site 357808000812 non-specific DNA interactions [nucleotide binding]; other site 357808000813 DNA binding site [nucleotide binding] 357808000814 sequence specific DNA binding site [nucleotide binding]; other site 357808000815 putative cAMP binding site [chemical binding]; other site 357808000816 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357808000817 catalytic core [active] 357808000818 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 357808000819 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808000820 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808000821 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 357808000822 putative active site [active] 357808000823 putative metal binding site [ion binding]; other site 357808000824 Transcriptional regulator [Transcription]; Region: LytR; COG1316 357808000825 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 357808000826 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 357808000827 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 357808000828 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 357808000829 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 357808000830 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808000831 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357808000832 Histidine kinase; Region: HisKA_3; pfam07730 357808000833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808000834 ATP binding site [chemical binding]; other site 357808000835 Mg2+ binding site [ion binding]; other site 357808000836 G-X-G motif; other site 357808000837 malate dehydrogenase; Reviewed; Region: PRK06223 357808000838 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 357808000839 NAD(P) binding site [chemical binding]; other site 357808000840 dimer interface [polypeptide binding]; other site 357808000841 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357808000842 substrate binding site [chemical binding]; other site 357808000843 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 357808000844 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357808000845 RNA binding surface [nucleotide binding]; other site 357808000846 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 357808000847 active site 357808000848 lipoprotein signal peptidase; Provisional; Region: PRK14790 357808000849 lipoprotein signal peptidase; Provisional; Region: PRK14787 357808000850 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 357808000851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357808000852 non-specific DNA binding site [nucleotide binding]; other site 357808000853 salt bridge; other site 357808000854 sequence-specific DNA binding site [nucleotide binding]; other site 357808000855 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 357808000856 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 357808000857 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357808000858 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808000859 putative active site [active] 357808000860 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 357808000861 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357808000862 NAD(P) binding site [chemical binding]; other site 357808000863 catalytic residues [active] 357808000864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357808000865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357808000866 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 357808000867 HlyD family secretion protein; Region: HlyD_3; pfam13437 357808000868 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357808000869 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357808000870 Walker A/P-loop; other site 357808000871 ATP binding site [chemical binding]; other site 357808000872 Q-loop/lid; other site 357808000873 ABC transporter signature motif; other site 357808000874 Walker B; other site 357808000875 D-loop; other site 357808000876 H-loop/switch region; other site 357808000877 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357808000878 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357808000879 FtsX-like permease family; Region: FtsX; pfam02687 357808000880 TAP-like protein; Region: Abhydrolase_4; pfam08386 357808000881 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 357808000882 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 357808000883 ligand binding site [chemical binding]; other site 357808000884 NAD binding site [chemical binding]; other site 357808000885 dimerization interface [polypeptide binding]; other site 357808000886 catalytic site [active] 357808000887 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 357808000888 putative L-serine binding site [chemical binding]; other site 357808000889 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 357808000890 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 357808000891 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 357808000892 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808000893 active site 357808000894 NTP binding site [chemical binding]; other site 357808000895 metal binding triad [ion binding]; metal-binding site 357808000896 antibiotic binding site [chemical binding]; other site 357808000897 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 357808000898 Fic family protein [Function unknown]; Region: COG3177 357808000899 Fic/DOC family; Region: Fic; pfam02661 357808000900 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 357808000901 Fic/DOC family; Region: Fic; cl00960 357808000902 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 357808000903 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 357808000904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808000905 ATP binding site [chemical binding]; other site 357808000906 putative Mg++ binding site [ion binding]; other site 357808000907 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 357808000908 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 357808000909 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 357808000910 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 357808000911 GTP binding site; other site 357808000912 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 357808000913 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 357808000914 HSP70 interaction site [polypeptide binding]; other site 357808000915 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 357808000916 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 357808000917 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 357808000918 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808000919 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357808000920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808000921 DNA binding residues [nucleotide binding] 357808000922 DNA primase; Validated; Region: dnaG; PRK05667 357808000923 CHC2 zinc finger; Region: zf-CHC2; pfam01807 357808000924 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 357808000925 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 357808000926 active site 357808000927 metal binding site [ion binding]; metal-binding site 357808000928 interdomain interaction site; other site 357808000929 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 357808000930 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 357808000931 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357808000932 Zn2+ binding site [ion binding]; other site 357808000933 Mg2+ binding site [ion binding]; other site 357808000934 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 357808000935 Ferredoxin [Energy production and conversion]; Region: COG1146 357808000936 4Fe-4S binding domain; Region: Fer4; cl02805 357808000937 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357808000938 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357808000939 ligand binding site [chemical binding]; other site 357808000940 flexible hinge region; other site 357808000941 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 357808000942 non-specific DNA interactions [nucleotide binding]; other site 357808000943 DNA binding site [nucleotide binding] 357808000944 sequence specific DNA binding site [nucleotide binding]; other site 357808000945 putative cAMP binding site [chemical binding]; other site 357808000946 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 357808000947 Zn binding site [ion binding]; other site 357808000948 Predicted transcriptional regulator [Transcription]; Region: COG1959 357808000949 Transcriptional regulator; Region: Rrf2; pfam02082 357808000950 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 357808000951 ADP-ribose binding site [chemical binding]; other site 357808000952 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 357808000953 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 357808000954 PLD-like domain; Region: PLDc_2; pfam13091 357808000955 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 357808000956 putative homodimer interface [polypeptide binding]; other site 357808000957 putative active site [active] 357808000958 catalytic site [active] 357808000959 DEAD-like helicases superfamily; Region: DEXDc; smart00487 357808000960 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808000961 putative Mg++ binding site [ion binding]; other site 357808000962 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 357808000963 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808000964 nucleotide binding region [chemical binding]; other site 357808000965 ATP-binding site [chemical binding]; other site 357808000966 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 357808000967 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 357808000968 Transposase IS200 like; Region: Y1_Tnp; cl00848 357808000969 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808000970 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808000971 Uncharacterized conserved protein [Function unknown]; Region: COG5483 357808000972 Protein of unknown function, DUF488; Region: DUF488; pfam04343 357808000973 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 357808000974 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 357808000975 Glyco_18 domain; Region: Glyco_18; smart00636 357808000976 active site 357808000977 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 357808000978 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 357808000979 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808000980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808000981 DNA binding residues [nucleotide binding] 357808000982 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 357808000983 PhoU domain; Region: PhoU; pfam01895 357808000984 PhoU domain; Region: PhoU; pfam01895 357808000985 acylphosphatase; Provisional; Region: PRK14444 357808000986 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 357808000987 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357808000988 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 357808000989 active site 357808000990 Response regulator receiver domain; Region: Response_reg; pfam00072 357808000991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808000992 active site 357808000993 phosphorylation site [posttranslational modification] 357808000994 intermolecular recognition site; other site 357808000995 dimerization interface [polypeptide binding]; other site 357808000996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808000997 dimer interface [polypeptide binding]; other site 357808000998 phosphorylation site [posttranslational modification] 357808000999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808001000 ATP binding site [chemical binding]; other site 357808001001 Mg2+ binding site [ion binding]; other site 357808001002 G-X-G motif; other site 357808001003 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 357808001004 Fe-S cluster binding site [ion binding]; other site 357808001005 active site 357808001006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357808001007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357808001008 active site 357808001009 tyrosine phenol-lyase; Provisional; Region: PRK13237 357808001010 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 357808001011 substrate binding site [chemical binding]; other site 357808001012 tetramer interface [polypeptide binding]; other site 357808001013 catalytic residue [active] 357808001014 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 357808001015 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 357808001016 Ligand Binding Site [chemical binding]; other site 357808001017 TilS substrate C-terminal domain; Region: TilS_C; smart00977 357808001018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357808001019 active site 357808001020 Bacterial PH domain; Region: DUF304; pfam03703 357808001021 cytidylate kinase; Provisional; Region: cmk; PRK00023 357808001022 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 357808001023 CMP-binding site; other site 357808001024 The sites determining sugar specificity; other site 357808001025 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 357808001026 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357808001027 catalytic residues [active] 357808001028 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 357808001029 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 357808001030 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 357808001031 Uncharacterized conserved protein [Function unknown]; Region: COG1656 357808001032 Protein of unknown function DUF82; Region: DUF82; pfam01927 357808001033 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 357808001034 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 357808001035 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 357808001036 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 357808001037 phosphodiesterase; Provisional; Region: PRK12704 357808001038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357808001039 Zn2+ binding site [ion binding]; other site 357808001040 Mg2+ binding site [ion binding]; other site 357808001041 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 357808001042 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 357808001043 Walker A/P-loop; other site 357808001044 ATP binding site [chemical binding]; other site 357808001045 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 357808001046 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 357808001047 Q-loop/lid; other site 357808001048 ABC transporter signature motif; other site 357808001049 Walker B; other site 357808001050 D-loop; other site 357808001051 H-loop/switch region; other site 357808001052 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 357808001053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808001054 motif II; other site 357808001055 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 357808001056 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 357808001057 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 357808001058 active site 357808001059 nucleophile elbow; other site 357808001060 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 357808001061 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 357808001062 active site 357808001063 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 357808001064 Response regulator receiver domain; Region: Response_reg; pfam00072 357808001065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808001066 active site 357808001067 phosphorylation site [posttranslational modification] 357808001068 intermolecular recognition site; other site 357808001069 dimerization interface [polypeptide binding]; other site 357808001070 Response regulator receiver domain; Region: Response_reg; pfam00072 357808001071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808001072 active site 357808001073 phosphorylation site [posttranslational modification] 357808001074 intermolecular recognition site; other site 357808001075 dimerization interface [polypeptide binding]; other site 357808001076 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808001077 GAF domain; Region: GAF_3; pfam13492 357808001078 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 357808001079 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357808001080 Zn2+ binding site [ion binding]; other site 357808001081 Mg2+ binding site [ion binding]; other site 357808001082 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 357808001083 putative hydrophobic ligand binding site [chemical binding]; other site 357808001084 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 357808001085 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357808001086 catalytic loop [active] 357808001087 iron binding site [ion binding]; other site 357808001088 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 357808001089 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 357808001090 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 357808001091 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 357808001092 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 357808001093 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 357808001094 TPR repeat; Region: TPR_11; pfam13414 357808001095 Methyltransferase domain; Region: Methyltransf_12; pfam08242 357808001096 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 357808001097 nucleotide binding site/active site [active] 357808001098 HIT family signature motif; other site 357808001099 catalytic residue [active] 357808001100 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 357808001101 active site 357808001102 Helix-turn-helix domain; Region: HTH_17; pfam12728 357808001103 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 357808001104 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 357808001105 oligomer interface [polypeptide binding]; other site 357808001106 active site 357808001107 metal binding site [ion binding]; metal-binding site 357808001108 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808001109 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 357808001110 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 357808001111 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357808001112 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 357808001113 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 357808001114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808001115 S-adenosylmethionine binding site [chemical binding]; other site 357808001116 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 357808001117 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 357808001118 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 357808001119 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 357808001120 NHL repeat; Region: NHL; pfam01436 357808001121 Uncharacterized conserved protein [Function unknown]; Region: COG3391 357808001122 NHL repeat; Region: NHL; pfam01436 357808001123 NHL repeat; Region: NHL; pfam01436 357808001124 NHL repeat; Region: NHL; pfam01436 357808001125 NHL repeat; Region: NHL; pfam01436 357808001126 NHL repeat; Region: NHL; pfam01436 357808001127 NHL repeat; Region: NHL; pfam01436 357808001128 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 357808001129 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357808001130 extended (e) SDRs; Region: SDR_e; cd08946 357808001131 NAD(P) binding site [chemical binding]; other site 357808001132 active site 357808001133 substrate binding site [chemical binding]; other site 357808001134 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 357808001135 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 357808001136 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 357808001137 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 357808001138 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 357808001139 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 357808001140 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 357808001141 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 357808001142 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 357808001143 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 357808001144 Staphylococcal nuclease homologues; Region: SNc; smart00318 357808001145 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 357808001146 Catalytic site; other site 357808001147 Lamin Tail Domain; Region: LTD; pfam00932 357808001148 Homeodomain-like domain; Region: HTH_23; pfam13384 357808001149 Winged helix-turn helix; Region: HTH_29; pfam13551 357808001150 Winged helix-turn helix; Region: HTH_33; pfam13592 357808001151 Staphylococcal nuclease homologues; Region: SNc; smart00318 357808001152 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 357808001153 Catalytic site; other site 357808001154 Lamin Tail Domain; Region: LTD; pfam00932 357808001155 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 357808001156 DNA methylase; Region: N6_N4_Mtase; pfam01555 357808001157 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357808001158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808001159 S-adenosylmethionine binding site [chemical binding]; other site 357808001160 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 357808001161 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 357808001162 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 357808001163 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 357808001164 SPFH domain / Band 7 family; Region: Band_7; pfam01145 357808001165 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 357808001166 SPFH domain / Band 7 family; Region: Band_7; pfam01145 357808001167 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 357808001168 active site 357808001169 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 357808001170 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 357808001171 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 357808001172 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 357808001173 classical (c) SDRs; Region: SDR_c; cd05233 357808001174 NAD(P) binding site [chemical binding]; other site 357808001175 active site 357808001176 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 357808001177 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 357808001178 dimer interface [polypeptide binding]; other site 357808001179 active site 357808001180 glycine-pyridoxal phosphate binding site [chemical binding]; other site 357808001181 folate binding site [chemical binding]; other site 357808001182 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 357808001183 pyrroline-5-carboxylate reductase; Region: PLN02688 357808001184 Bacterial SH3 domain; Region: SH3_3; pfam08239 357808001185 Bacterial SH3 domain; Region: SH3_3; pfam08239 357808001186 Bacterial SH3 domain; Region: SH3_3; pfam08239 357808001187 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 357808001188 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 357808001189 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 357808001190 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 357808001191 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 357808001192 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 357808001193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808001194 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357808001195 putative substrate translocation pore; other site 357808001196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808001197 S-adenosylmethionine binding site [chemical binding]; other site 357808001198 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 357808001199 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 357808001200 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 357808001201 Bacterial sugar transferase; Region: Bac_transf; pfam02397 357808001202 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357808001203 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 357808001204 inhibitor-cofactor binding pocket; inhibition site 357808001205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808001206 catalytic residue [active] 357808001207 diaminopimelate decarboxylase; Region: lysA; TIGR01048 357808001208 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 357808001209 active site 357808001210 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357808001211 substrate binding site [chemical binding]; other site 357808001212 catalytic residues [active] 357808001213 dimer interface [polypeptide binding]; other site 357808001214 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 357808001215 TrkA-C domain; Region: TrkA_C; pfam02080 357808001216 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 357808001217 dimer interface [polypeptide binding]; other site 357808001218 catalytic triad [active] 357808001219 peroxidatic and resolving cysteines [active] 357808001220 PAS domain; Region: PAS_8; pfam13188 357808001221 PAS fold; Region: PAS_4; pfam08448 357808001222 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808001223 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 357808001224 Restriction endonuclease; Region: Mrr_cat; pfam04471 357808001225 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808001226 GAF domain; Region: GAF; pfam01590 357808001227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808001228 dimer interface [polypeptide binding]; other site 357808001229 phosphorylation site [posttranslational modification] 357808001230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808001231 ATP binding site [chemical binding]; other site 357808001232 Mg2+ binding site [ion binding]; other site 357808001233 G-X-G motif; other site 357808001234 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 357808001235 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 357808001236 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 357808001237 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 357808001238 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 357808001239 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 357808001240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808001241 dimer interface [polypeptide binding]; other site 357808001242 conserved gate region; other site 357808001243 putative PBP binding loops; other site 357808001244 ABC-ATPase subunit interface; other site 357808001245 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 357808001246 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 357808001247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808001248 dimer interface [polypeptide binding]; other site 357808001249 conserved gate region; other site 357808001250 putative PBP binding loops; other site 357808001251 ABC-ATPase subunit interface; other site 357808001252 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 357808001253 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357808001254 Walker A/P-loop; other site 357808001255 ATP binding site [chemical binding]; other site 357808001256 Q-loop/lid; other site 357808001257 ABC transporter signature motif; other site 357808001258 Walker B; other site 357808001259 D-loop; other site 357808001260 H-loop/switch region; other site 357808001261 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357808001262 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 357808001263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357808001264 Walker A/P-loop; other site 357808001265 ATP binding site [chemical binding]; other site 357808001266 Q-loop/lid; other site 357808001267 ABC transporter signature motif; other site 357808001268 Walker B; other site 357808001269 D-loop; other site 357808001270 H-loop/switch region; other site 357808001271 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 357808001272 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 357808001273 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357808001274 Walker A/P-loop; other site 357808001275 ATP binding site [chemical binding]; other site 357808001276 Q-loop/lid; other site 357808001277 ABC transporter signature motif; other site 357808001278 Walker B; other site 357808001279 D-loop; other site 357808001280 H-loop/switch region; other site 357808001281 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357808001282 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 357808001283 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357808001284 Walker A/P-loop; other site 357808001285 ATP binding site [chemical binding]; other site 357808001286 Q-loop/lid; other site 357808001287 ABC transporter signature motif; other site 357808001288 Walker B; other site 357808001289 D-loop; other site 357808001290 H-loop/switch region; other site 357808001291 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 357808001292 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808001293 putative active site [active] 357808001294 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808001295 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 357808001296 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808001297 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808001298 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 357808001299 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808001300 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 357808001301 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808001302 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 357808001303 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 357808001304 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808001305 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808001306 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 357808001307 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808001308 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808001309 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 357808001310 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 357808001311 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808001312 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 357808001313 putative active site [active] 357808001314 YdjC motif; other site 357808001315 Mg binding site [ion binding]; other site 357808001316 homodimer interface [polypeptide binding]; other site 357808001317 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 357808001318 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 357808001319 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 357808001320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808001321 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 357808001322 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 357808001323 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357808001324 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 357808001325 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 357808001326 5S rRNA interface [nucleotide binding]; other site 357808001327 CTC domain interface [polypeptide binding]; other site 357808001328 L16 interface [polypeptide binding]; other site 357808001329 LexA repressor; Validated; Region: PRK00215 357808001330 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 357808001331 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 357808001332 Catalytic site [active] 357808001333 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 357808001334 DUF35 OB-fold domain; Region: DUF35; pfam01796 357808001335 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 357808001336 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 357808001337 active site 357808001338 hypothetical protein; Provisional; Region: PRK04262 357808001339 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 357808001340 dimer interface [polypeptide binding]; other site 357808001341 active site 357808001342 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 357808001343 homodimer interface [polypeptide binding]; other site 357808001344 catalytic residues [active] 357808001345 NAD binding site [chemical binding]; other site 357808001346 substrate binding pocket [chemical binding]; other site 357808001347 flexible flap; other site 357808001348 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808001349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808001350 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808001351 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 357808001352 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357808001353 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 357808001354 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 357808001355 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 357808001356 carboxyltransferase (CT) interaction site; other site 357808001357 biotinylation site [posttranslational modification]; other site 357808001358 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 357808001359 L-aspartate oxidase; Provisional; Region: PRK06175 357808001360 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 357808001361 Quinolinate synthetase A protein; Region: NadA; pfam02445 357808001362 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 357808001363 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 357808001364 dimerization interface [polypeptide binding]; other site 357808001365 active site 357808001366 Winged helix-turn helix; Region: HTH_29; pfam13551 357808001367 Homeodomain-like domain; Region: HTH_32; pfam13565 357808001368 Winged helix-turn helix; Region: HTH_33; pfam13592 357808001369 DDE superfamily endonuclease; Region: DDE_3; pfam13358 357808001370 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808001371 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 357808001372 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 357808001373 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 357808001374 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357808001375 putative DNA binding site [nucleotide binding]; other site 357808001376 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 357808001377 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 357808001378 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 357808001379 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808001380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808001381 active site 357808001382 phosphorylation site [posttranslational modification] 357808001383 intermolecular recognition site; other site 357808001384 dimerization interface [polypeptide binding]; other site 357808001385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808001386 DNA binding residues [nucleotide binding] 357808001387 dimerization interface [polypeptide binding]; other site 357808001388 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 357808001389 Predicted membrane protein [Function unknown]; Region: COG2311 357808001390 Protein of unknown function (DUF418); Region: DUF418; pfam04235 357808001391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357808001392 Histidine kinase; Region: HisKA_3; pfam07730 357808001393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808001394 ATP binding site [chemical binding]; other site 357808001395 Mg2+ binding site [ion binding]; other site 357808001396 G-X-G motif; other site 357808001397 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 357808001398 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 357808001399 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 357808001400 DEAD-like helicases superfamily; Region: DEXDc; smart00487 357808001401 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808001402 ATP binding site [chemical binding]; other site 357808001403 putative Mg++ binding site [ion binding]; other site 357808001404 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 357808001405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808001406 nucleotide binding region [chemical binding]; other site 357808001407 ATP-binding site [chemical binding]; other site 357808001408 histidinol-phosphate aminotransferase; Provisional; Region: PRK03967 357808001409 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 357808001410 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357808001411 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 357808001412 Predicted transcriptional regulators [Transcription]; Region: COG1378 357808001413 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 357808001414 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 357808001415 C-terminal domain interface [polypeptide binding]; other site 357808001416 sugar binding site [chemical binding]; other site 357808001417 Uncharacterized conserved protein [Function unknown]; Region: COG3379 357808001418 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 357808001419 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357808001420 active site 357808001421 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808001422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808001423 S-adenosylmethionine binding site [chemical binding]; other site 357808001424 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808001425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808001426 S-adenosylmethionine binding site [chemical binding]; other site 357808001427 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 357808001428 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 357808001429 Uncharacterized conserved protein [Function unknown]; Region: COG3379 357808001430 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 357808001431 Methyltransferase domain; Region: Methyltransf_12; pfam08242 357808001432 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808001433 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808001434 DNA binding residues [nucleotide binding] 357808001435 dimerization interface [polypeptide binding]; other site 357808001436 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 357808001437 Kelch motif; Region: Kelch_1; pfam01344 357808001438 Kelch domain; Region: Kelch; smart00612 357808001439 Kelch motif; Region: Kelch_1; pfam01344 357808001440 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 357808001441 Kelch motif; Region: Kelch_1; pfam01344 357808001442 Galactose oxidase, central domain; Region: Kelch_3; cl02701 357808001443 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 357808001444 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 357808001445 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 357808001446 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 357808001447 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 357808001448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808001449 NAD(P) binding site [chemical binding]; other site 357808001450 active site 357808001451 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357808001452 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 357808001453 dimer interface [polypeptide binding]; other site 357808001454 substrate binding site [chemical binding]; other site 357808001455 metal binding site [ion binding]; metal-binding site 357808001456 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 357808001457 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808001458 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808001459 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808001460 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808001461 GAF domain; Region: GAF_2; pfam13185 357808001462 GAF domain; Region: GAF_3; pfam13492 357808001463 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 357808001464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808001465 dimer interface [polypeptide binding]; other site 357808001466 phosphorylation site [posttranslational modification] 357808001467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808001468 ATP binding site [chemical binding]; other site 357808001469 Mg2+ binding site [ion binding]; other site 357808001470 G-X-G motif; other site 357808001471 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 357808001472 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 357808001473 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 357808001474 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357808001475 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 357808001476 substrate binding site [chemical binding]; other site 357808001477 ATP binding site [chemical binding]; other site 357808001478 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 357808001479 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 357808001480 homotetramer interface [polypeptide binding]; other site 357808001481 ligand binding site [chemical binding]; other site 357808001482 catalytic site [active] 357808001483 NAD binding site [chemical binding]; other site 357808001484 S-adenosylmethionine synthetase; Validated; Region: PRK05250 357808001485 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 357808001486 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 357808001487 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 357808001488 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 357808001489 nudix motif; other site 357808001490 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808001491 Double zinc ribbon; Region: DZR; pfam12773 357808001492 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357808001493 catalytic residues [active] 357808001494 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 357808001495 substrate binding site [chemical binding]; other site 357808001496 putative active site [active] 357808001497 redox center [active] 357808001498 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357808001499 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357808001500 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 357808001501 Walker A/P-loop; other site 357808001502 ATP binding site [chemical binding]; other site 357808001503 Q-loop/lid; other site 357808001504 ABC transporter signature motif; other site 357808001505 Walker B; other site 357808001506 D-loop; other site 357808001507 H-loop/switch region; other site 357808001508 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357808001509 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357808001510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808001511 Walker A/P-loop; other site 357808001512 ATP binding site [chemical binding]; other site 357808001513 Q-loop/lid; other site 357808001514 ABC transporter signature motif; other site 357808001515 Walker B; other site 357808001516 D-loop; other site 357808001517 H-loop/switch region; other site 357808001518 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 357808001519 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 357808001520 NADP binding site [chemical binding]; other site 357808001521 homodimer interface [polypeptide binding]; other site 357808001522 active site 357808001523 KduI/IolB family; Region: KduI; pfam04962 357808001524 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357808001525 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 357808001526 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 357808001527 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 357808001528 XdhC Rossmann domain; Region: XdhC_C; pfam13478 357808001529 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 357808001530 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357808001531 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 357808001532 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 357808001533 NodB motif; other site 357808001534 active site 357808001535 metal binding site [ion binding]; metal-binding site 357808001536 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808001537 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808001538 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808001539 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808001540 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808001541 Protein of unknown function (DUF402); Region: DUF402; pfam04167 357808001542 Methyltransferase domain; Region: Methyltransf_11; pfam08241 357808001543 rod shape-determining protein MreB; Provisional; Region: PRK13930 357808001544 MreB and similar proteins; Region: MreB_like; cd10225 357808001545 nucleotide binding site [chemical binding]; other site 357808001546 Mg binding site [ion binding]; other site 357808001547 putative protofilament interaction site [polypeptide binding]; other site 357808001548 RodZ interaction site [polypeptide binding]; other site 357808001549 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 357808001550 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 357808001551 gamma subunit interface [polypeptide binding]; other site 357808001552 epsilon subunit interface [polypeptide binding]; other site 357808001553 LBP interface [polypeptide binding]; other site 357808001554 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 357808001555 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357808001556 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 357808001557 alpha subunit interaction interface [polypeptide binding]; other site 357808001558 Walker A motif; other site 357808001559 ATP binding site [chemical binding]; other site 357808001560 Walker B motif; other site 357808001561 inhibitor binding site; inhibition site 357808001562 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357808001563 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 357808001564 core domain interface [polypeptide binding]; other site 357808001565 delta subunit interface [polypeptide binding]; other site 357808001566 epsilon subunit interface [polypeptide binding]; other site 357808001567 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 357808001568 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357808001569 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 357808001570 beta subunit interaction interface [polypeptide binding]; other site 357808001571 Walker A motif; other site 357808001572 ATP binding site [chemical binding]; other site 357808001573 Walker B motif; other site 357808001574 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357808001575 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 357808001576 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 357808001577 F0F1 ATP synthase subunit B; Provisional; Region: PRK14473 357808001578 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 357808001579 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636 357808001580 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 357808001581 Response regulator receiver domain; Region: Response_reg; pfam00072 357808001582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808001583 phosphorylation site [posttranslational modification] 357808001584 intermolecular recognition site; other site 357808001585 Response regulator receiver domain; Region: Response_reg; pfam00072 357808001586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808001587 active site 357808001588 phosphorylation site [posttranslational modification] 357808001589 intermolecular recognition site; other site 357808001590 dimerization interface [polypeptide binding]; other site 357808001591 GAF domain; Region: GAF_3; pfam13492 357808001592 GAF domain; Region: GAF_2; pfam13185 357808001593 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808001594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808001595 dimer interface [polypeptide binding]; other site 357808001596 phosphorylation site [posttranslational modification] 357808001597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808001598 ATP binding site [chemical binding]; other site 357808001599 Mg2+ binding site [ion binding]; other site 357808001600 G-X-G motif; other site 357808001601 PspC domain; Region: PspC; pfam04024 357808001602 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 357808001603 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357808001604 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357808001605 DNA binding site [nucleotide binding] 357808001606 domain linker motif; other site 357808001607 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357808001608 dimerization interface [polypeptide binding]; other site 357808001609 ligand binding site [chemical binding]; other site 357808001610 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 357808001611 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 357808001612 Walker A/P-loop; other site 357808001613 ATP binding site [chemical binding]; other site 357808001614 Q-loop/lid; other site 357808001615 ABC transporter signature motif; other site 357808001616 Walker B; other site 357808001617 D-loop; other site 357808001618 H-loop/switch region; other site 357808001619 TOBE domain; Region: TOBE; cl01440 357808001620 TOBE domain; Region: TOBE; pfam03459 357808001621 Domain of unknown function (DUF385); Region: DUF385; cl04387 357808001622 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 357808001623 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 357808001624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357808001625 non-specific DNA binding site [nucleotide binding]; other site 357808001626 salt bridge; other site 357808001627 sequence-specific DNA binding site [nucleotide binding]; other site 357808001628 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 357808001629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 357808001630 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 357808001631 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 357808001632 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 357808001633 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808001634 FeS/SAM binding site; other site 357808001635 TRAM domain; Region: TRAM; pfam01938 357808001636 Penicillinase repressor; Region: Pencillinase_R; pfam03965 357808001637 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 357808001638 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 357808001639 substrate binding pocket [chemical binding]; other site 357808001640 chain length determination region; other site 357808001641 substrate-Mg2+ binding site; other site 357808001642 catalytic residues [active] 357808001643 aspartate-rich region 1; other site 357808001644 active site lid residues [active] 357808001645 aspartate-rich region 2; other site 357808001646 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 357808001647 Protein of unknown function (DUF1626); Region: DUF1626; pfam07788 357808001648 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 357808001649 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 357808001650 metal ion-dependent adhesion site (MIDAS); other site 357808001651 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 357808001652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808001653 Walker A motif; other site 357808001654 ATP binding site [chemical binding]; other site 357808001655 Walker B motif; other site 357808001656 arginine finger; other site 357808001657 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 357808001658 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357808001659 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808001660 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808001661 BtpA family; Region: BtpA; cl00440 357808001662 pteridine reductase; Provisional; Region: PRK09135 357808001663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808001664 NAD(P) binding site [chemical binding]; other site 357808001665 active site 357808001666 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 357808001667 trimer interface [polypeptide binding]; other site 357808001668 dimer interface [polypeptide binding]; other site 357808001669 putative active site [active] 357808001670 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 357808001671 heterodimer interface [polypeptide binding]; other site 357808001672 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 357808001673 substrate interaction site [chemical binding]; other site 357808001674 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 357808001675 B12 binding site [chemical binding]; other site 357808001676 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 357808001677 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 357808001678 active site 357808001679 substrate binding site [chemical binding]; other site 357808001680 coenzyme B12 binding site [chemical binding]; other site 357808001681 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 357808001682 B12 binding site [chemical binding]; other site 357808001683 cobalt ligand [ion binding]; other site 357808001684 membrane ATPase/protein kinase; Provisional; Region: PRK09435 357808001685 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 357808001686 Walker A; other site 357808001687 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808001688 active site 357808001689 NTP binding site [chemical binding]; other site 357808001690 metal binding triad [ion binding]; metal-binding site 357808001691 antibiotic binding site [chemical binding]; other site 357808001692 Uncharacterized conserved protein [Function unknown]; Region: COG2361 357808001693 DinB superfamily; Region: DinB_2; pfam12867 357808001694 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 357808001695 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 357808001696 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 357808001697 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 357808001698 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 357808001699 FeoA domain; Region: FeoA; pfam04023 357808001700 FeoA domain; Region: FeoA; pfam04023 357808001701 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 357808001702 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 357808001703 G1 box; other site 357808001704 GTP/Mg2+ binding site [chemical binding]; other site 357808001705 Switch I region; other site 357808001706 G2 box; other site 357808001707 G3 box; other site 357808001708 Switch II region; other site 357808001709 G4 box; other site 357808001710 G5 box; other site 357808001711 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 357808001712 Nucleoside recognition; Region: Gate; pfam07670 357808001713 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 357808001714 FeoC like transcriptional regulator; Region: FeoC; pfam09012 357808001715 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 357808001716 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 357808001717 homodimer interface [polypeptide binding]; other site 357808001718 Walker A motif; other site 357808001719 ATP binding site [chemical binding]; other site 357808001720 hydroxycobalamin binding site [chemical binding]; other site 357808001721 Walker B motif; other site 357808001722 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 357808001723 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 357808001724 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 357808001725 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 357808001726 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 357808001727 putative dimer interface [polypeptide binding]; other site 357808001728 active site pocket [active] 357808001729 putative cataytic base [active] 357808001730 cobalt transport protein CbiM; Validated; Region: PRK08319 357808001731 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 357808001732 cobalt transport protein CbiN; Provisional; Region: PRK02898 357808001733 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 357808001734 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357808001735 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 357808001736 Walker A/P-loop; other site 357808001737 ATP binding site [chemical binding]; other site 357808001738 Q-loop/lid; other site 357808001739 ABC transporter signature motif; other site 357808001740 Walker B; other site 357808001741 D-loop; other site 357808001742 H-loop/switch region; other site 357808001743 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 357808001744 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 357808001745 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 357808001746 putative active site [active] 357808001747 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 357808001748 putative active site [active] 357808001749 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 357808001750 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 357808001751 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 357808001752 Precorrin-8X methylmutase; Region: CbiC; pfam02570 357808001753 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 357808001754 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 357808001755 active site 357808001756 putative homodimer interface [polypeptide binding]; other site 357808001757 SAM binding site [chemical binding]; other site 357808001758 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 357808001759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808001760 S-adenosylmethionine binding site [chemical binding]; other site 357808001761 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 357808001762 active site 357808001763 SAM binding site [chemical binding]; other site 357808001764 homodimer interface [polypeptide binding]; other site 357808001765 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 357808001766 active site 357808001767 SAM binding site [chemical binding]; other site 357808001768 homodimer interface [polypeptide binding]; other site 357808001769 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 357808001770 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 357808001771 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 357808001772 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 357808001773 active site 357808001774 SAM binding site [chemical binding]; other site 357808001775 homodimer interface [polypeptide binding]; other site 357808001776 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 357808001777 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 357808001778 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 357808001779 active site 357808001780 SAM binding site [chemical binding]; other site 357808001781 homodimer interface [polypeptide binding]; other site 357808001782 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 357808001783 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 357808001784 catalytic triad [active] 357808001785 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 357808001786 homotrimer interface [polypeptide binding]; other site 357808001787 Walker A motif; other site 357808001788 GTP binding site [chemical binding]; other site 357808001789 Walker B motif; other site 357808001790 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 357808001791 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357808001792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808001793 homodimer interface [polypeptide binding]; other site 357808001794 catalytic residue [active] 357808001795 cobyric acid synthase; Provisional; Region: PRK00784 357808001796 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 357808001797 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 357808001798 catalytic triad [active] 357808001799 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 357808001800 ABC1 family; Region: ABC1; cl17513 357808001801 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 357808001802 substrate binding site [chemical binding]; other site 357808001803 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 357808001804 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 357808001805 Mg++ binding site [ion binding]; other site 357808001806 putative catalytic motif [active] 357808001807 substrate binding site [chemical binding]; other site 357808001808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357808001809 active site 357808001810 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 357808001811 C-terminal peptidase (prc); Region: prc; TIGR00225 357808001812 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 357808001813 protein binding site [polypeptide binding]; other site 357808001814 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 357808001815 Catalytic dyad [active] 357808001816 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808001817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808001818 binding surface 357808001819 TPR motif; other site 357808001820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808001821 TPR repeat; Region: TPR_11; pfam13414 357808001822 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808001823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808001824 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808001825 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 357808001826 Protein of unknown function DUF58; Region: DUF58; pfam01882 357808001827 MoxR-like ATPases [General function prediction only]; Region: COG0714 357808001828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808001829 Walker A motif; other site 357808001830 ATP binding site [chemical binding]; other site 357808001831 Walker B motif; other site 357808001832 arginine finger; other site 357808001833 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 357808001834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808001835 PAS domain; Region: PAS_9; pfam13426 357808001836 putative active site [active] 357808001837 heme pocket [chemical binding]; other site 357808001838 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357808001839 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357808001840 metal binding site [ion binding]; metal-binding site 357808001841 active site 357808001842 I-site; other site 357808001843 Protein of unknown function DUF111; Region: DUF111; pfam01969 357808001844 Predicted permease; Region: DUF318; cl17795 357808001845 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 357808001846 metal binding site 2 [ion binding]; metal-binding site 357808001847 putative DNA binding helix; other site 357808001848 metal binding site 1 [ion binding]; metal-binding site 357808001849 dimer interface [polypeptide binding]; other site 357808001850 structural Zn2+ binding site [ion binding]; other site 357808001851 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357808001852 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357808001853 ligand binding site [chemical binding]; other site 357808001854 flexible hinge region; other site 357808001855 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 357808001856 putative switch regulator; other site 357808001857 non-specific DNA interactions [nucleotide binding]; other site 357808001858 DNA binding site [nucleotide binding] 357808001859 sequence specific DNA binding site [nucleotide binding]; other site 357808001860 putative cAMP binding site [chemical binding]; other site 357808001861 Probable zinc-binding domain; Region: zf-trcl; pfam13451 357808001862 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 357808001863 RNA binding site [nucleotide binding]; other site 357808001864 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 357808001865 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 357808001866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808001867 S-adenosylmethionine binding site [chemical binding]; other site 357808001868 PAS domain; Region: PAS; smart00091 357808001869 PAS domain; Region: PAS_9; pfam13426 357808001870 putative active site [active] 357808001871 heme pocket [chemical binding]; other site 357808001872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808001873 PAS domain; Region: PAS_9; pfam13426 357808001874 putative active site [active] 357808001875 heme pocket [chemical binding]; other site 357808001876 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808001877 translocation protein TolB; Provisional; Region: tolB; PRK00178 357808001878 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 357808001879 acyl-CoA synthetase; Validated; Region: PRK08162 357808001880 acyl-activating enzyme (AAE) consensus motif; other site 357808001881 putative active site [active] 357808001882 AMP binding site [chemical binding]; other site 357808001883 putative CoA binding site [chemical binding]; other site 357808001884 Haem-binding domain; Region: Haem_bd; pfam14376 357808001885 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 357808001886 ApbE family; Region: ApbE; pfam02424 357808001887 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 357808001888 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808001889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808001890 active site 357808001891 phosphorylation site [posttranslational modification] 357808001892 intermolecular recognition site; other site 357808001893 dimerization interface [polypeptide binding]; other site 357808001894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808001895 DNA binding site [nucleotide binding] 357808001896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808001897 dimer interface [polypeptide binding]; other site 357808001898 phosphorylation site [posttranslational modification] 357808001899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808001900 ATP binding site [chemical binding]; other site 357808001901 Mg2+ binding site [ion binding]; other site 357808001902 G-X-G motif; other site 357808001903 endonuclease IV; Provisional; Region: PRK01060 357808001904 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 357808001905 AP (apurinic/apyrimidinic) site pocket; other site 357808001906 DNA interaction; other site 357808001907 Metal-binding active site; metal-binding site 357808001908 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 357808001909 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 357808001910 active site 357808001911 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808001912 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808001913 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808001914 CHAT domain; Region: CHAT; cl17868 357808001915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357808001916 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 357808001917 putative active site [active] 357808001918 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 357808001919 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 357808001920 Walker A/P-loop; other site 357808001921 ATP binding site [chemical binding]; other site 357808001922 Q-loop/lid; other site 357808001923 ABC transporter signature motif; other site 357808001924 Walker B; other site 357808001925 D-loop; other site 357808001926 H-loop/switch region; other site 357808001927 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 357808001928 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357808001929 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 357808001930 acyl-activating enzyme (AAE) consensus motif; other site 357808001931 putative AMP binding site [chemical binding]; other site 357808001932 putative active site [active] 357808001933 putative CoA binding site [chemical binding]; other site 357808001934 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357808001935 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 357808001936 TM-ABC transporter signature motif; other site 357808001937 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 357808001938 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 357808001939 TM-ABC transporter signature motif; other site 357808001940 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 357808001941 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 357808001942 putative ligand binding site [chemical binding]; other site 357808001943 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 357808001944 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 357808001945 Walker A/P-loop; other site 357808001946 ATP binding site [chemical binding]; other site 357808001947 Q-loop/lid; other site 357808001948 ABC transporter signature motif; other site 357808001949 Walker B; other site 357808001950 D-loop; other site 357808001951 H-loop/switch region; other site 357808001952 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 357808001953 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357808001954 acyl-activating enzyme (AAE) consensus motif; other site 357808001955 active site 357808001956 AMP binding site [chemical binding]; other site 357808001957 CoA binding site [chemical binding]; other site 357808001958 Homeodomain-like domain; Region: HTH_23; pfam13384 357808001959 Winged helix-turn helix; Region: HTH_29; pfam13551 357808001960 Homeodomain-like domain; Region: HTH_32; pfam13565 357808001961 Winged helix-turn helix; Region: HTH_33; pfam13592 357808001962 DDE superfamily endonuclease; Region: DDE_3; pfam13358 357808001963 Helix-turn-helix domain; Region: HTH_28; pfam13518 357808001964 Winged helix-turn helix; Region: HTH_29; pfam13551 357808001965 Homeodomain-like domain; Region: HTH_32; pfam13565 357808001966 DDE superfamily endonuclease; Region: DDE_3; pfam13358 357808001967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 357808001968 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 357808001969 Interdomain contacts; other site 357808001970 Cytokine receptor motif; other site 357808001971 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808001972 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808001973 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 357808001974 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 357808001975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357808001976 non-specific DNA binding site [nucleotide binding]; other site 357808001977 salt bridge; other site 357808001978 sequence-specific DNA binding site [nucleotide binding]; other site 357808001979 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808001980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808001981 TPR motif; other site 357808001982 binding surface 357808001983 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808001984 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808001985 binding surface 357808001986 TPR motif; other site 357808001987 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808001988 Tetratricopeptide repeat; Region: TPR_10; pfam13374 357808001989 Tetratricopeptide repeat; Region: TPR_10; cl17452 357808001990 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 357808001991 Proline racemase; Region: Pro_racemase; pfam05544 357808001992 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 357808001993 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 357808001994 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 357808001995 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 357808001996 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 357808001997 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 357808001998 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 357808001999 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 357808002000 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 357808002001 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 357808002002 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 357808002003 Predicted transcriptional regulator [Transcription]; Region: COG2378 357808002004 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 357808002005 WYL domain; Region: WYL; pfam13280 357808002006 Protein of unknown function (DUF433); Region: DUF433; pfam04255 357808002007 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 357808002008 putative catalytic site [active] 357808002009 putative metal binding site [ion binding]; other site 357808002010 putative phosphate binding site [ion binding]; other site 357808002011 TPR repeat; Region: TPR_11; pfam13414 357808002012 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 357808002013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 357808002014 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 357808002015 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 357808002016 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 357808002017 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 357808002018 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 357808002019 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 357808002020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002021 TPR motif; other site 357808002022 Tetratricopeptide repeat; Region: TPR_16; pfam13432 357808002023 binding surface 357808002024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002025 TPR motif; other site 357808002026 binding surface 357808002027 TPR repeat; Region: TPR_11; pfam13414 357808002028 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 357808002029 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 357808002030 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 357808002031 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 357808002032 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357808002033 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357808002034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808002035 Walker A/P-loop; other site 357808002036 ATP binding site [chemical binding]; other site 357808002037 Q-loop/lid; other site 357808002038 ABC transporter signature motif; other site 357808002039 Walker B; other site 357808002040 D-loop; other site 357808002041 H-loop/switch region; other site 357808002042 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 357808002043 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 357808002044 active site 357808002045 catalytic triad [active] 357808002046 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808002047 MFS_1 like family; Region: MFS_1_like; pfam12832 357808002048 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808002049 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808002050 active site 357808002051 ATP binding site [chemical binding]; other site 357808002052 substrate binding site [chemical binding]; other site 357808002053 activation loop (A-loop); other site 357808002054 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 357808002055 TPR repeat; Region: TPR_11; pfam13414 357808002056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002057 binding surface 357808002058 TPR motif; other site 357808002059 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 357808002060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002061 binding surface 357808002062 TPR motif; other site 357808002063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002064 binding surface 357808002065 TPR motif; other site 357808002066 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 357808002067 Domain of unknown function DUF77; Region: DUF77; pfam01910 357808002068 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 357808002069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808002070 dimer interface [polypeptide binding]; other site 357808002071 conserved gate region; other site 357808002072 putative PBP binding loops; other site 357808002073 ABC-ATPase subunit interface; other site 357808002074 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 357808002075 NMT1/THI5 like; Region: NMT1; pfam09084 357808002076 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 357808002077 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 357808002078 Walker A/P-loop; other site 357808002079 ATP binding site [chemical binding]; other site 357808002080 Q-loop/lid; other site 357808002081 ABC transporter signature motif; other site 357808002082 Walker B; other site 357808002083 D-loop; other site 357808002084 H-loop/switch region; other site 357808002085 Protein of unknown function (DUF433); Region: DUF433; pfam04255 357808002086 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 357808002087 active site 357808002088 catalytic triad [active] 357808002089 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808002090 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808002091 phosphopeptide binding site; other site 357808002092 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357808002093 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 357808002094 putative active site [active] 357808002095 putative metal binding site [ion binding]; other site 357808002096 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 357808002097 nudix motif; other site 357808002098 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808002099 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808002100 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808002101 putative active site [active] 357808002102 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808002103 putative active site [active] 357808002104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808002105 Walker A/P-loop; other site 357808002106 ATP binding site [chemical binding]; other site 357808002107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002108 TPR motif; other site 357808002109 binding surface 357808002110 TPR repeat; Region: TPR_11; pfam13414 357808002111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002112 binding surface 357808002113 TPR motif; other site 357808002114 TPR repeat; Region: TPR_11; pfam13414 357808002115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002116 binding surface 357808002117 TPR motif; other site 357808002118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002119 binding surface 357808002120 TPR motif; other site 357808002121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002122 TPR motif; other site 357808002123 binding surface 357808002124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002125 TPR motif; other site 357808002126 binding surface 357808002127 TPR repeat; Region: TPR_11; pfam13414 357808002128 TPR repeat; Region: TPR_11; pfam13414 357808002129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002130 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808002131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002132 binding surface 357808002133 TPR motif; other site 357808002134 TPR repeat; Region: TPR_11; pfam13414 357808002135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002136 binding surface 357808002137 TPR motif; other site 357808002138 TPR repeat; Region: TPR_11; pfam13414 357808002139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002140 binding surface 357808002141 TPR motif; other site 357808002142 TPR repeat; Region: TPR_11; pfam13414 357808002143 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 357808002144 amidase catalytic site [active] 357808002145 Zn binding residues [ion binding]; other site 357808002146 substrate binding site [chemical binding]; other site 357808002147 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808002148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808002149 active site 357808002150 phosphorylation site [posttranslational modification] 357808002151 intermolecular recognition site; other site 357808002152 dimerization interface [polypeptide binding]; other site 357808002153 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808002154 DNA binding residues [nucleotide binding] 357808002155 dimerization interface [polypeptide binding]; other site 357808002156 MoxR-like ATPases [General function prediction only]; Region: COG0714 357808002157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808002158 Walker A motif; other site 357808002159 ATP binding site [chemical binding]; other site 357808002160 Walker B motif; other site 357808002161 arginine finger; other site 357808002162 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 357808002163 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 357808002164 putative substrate binding site [chemical binding]; other site 357808002165 putative ATP binding site [chemical binding]; other site 357808002166 Protein of unknown function (DUF433); Region: DUF433; pfam04255 357808002167 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 357808002168 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 357808002169 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 357808002170 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 357808002171 active site 357808002172 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 357808002173 metal-binding site [ion binding] 357808002174 multifunctional aminopeptidase A; Provisional; Region: PRK00913 357808002175 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 357808002176 interface (dimer of trimers) [polypeptide binding]; other site 357808002177 Substrate-binding/catalytic site; other site 357808002178 Zn-binding sites [ion binding]; other site 357808002179 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 357808002180 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 357808002181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808002182 active site 357808002183 phosphorylation site [posttranslational modification] 357808002184 intermolecular recognition site; other site 357808002185 dimerization interface [polypeptide binding]; other site 357808002186 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357808002187 Zn2+ binding site [ion binding]; other site 357808002188 Mg2+ binding site [ion binding]; other site 357808002189 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 357808002190 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357808002191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808002192 homodimer interface [polypeptide binding]; other site 357808002193 catalytic residue [active] 357808002194 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 357808002195 active site 357808002196 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 357808002197 active site 357808002198 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 357808002199 homodecamer interface [polypeptide binding]; other site 357808002200 GTP cyclohydrolase I; Provisional; Region: PLN03044 357808002201 active site 357808002202 putative catalytic site residues [active] 357808002203 zinc binding site [ion binding]; other site 357808002204 GTP-CH-I/GFRP interaction surface; other site 357808002205 short chain dehydrogenase; Provisional; Region: PRK07454 357808002206 classical (c) SDRs; Region: SDR_c; cd05233 357808002207 NAD(P) binding site [chemical binding]; other site 357808002208 active site 357808002209 Predicted transcriptional regulator [Transcription]; Region: COG2345 357808002210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357808002211 putative Zn2+ binding site [ion binding]; other site 357808002212 putative DNA binding site [nucleotide binding]; other site 357808002213 FeS assembly ATPase SufC; Region: sufC; TIGR01978 357808002214 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 357808002215 Walker A/P-loop; other site 357808002216 ATP binding site [chemical binding]; other site 357808002217 Q-loop/lid; other site 357808002218 ABC transporter signature motif; other site 357808002219 Walker B; other site 357808002220 D-loop; other site 357808002221 H-loop/switch region; other site 357808002222 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 357808002223 FeS assembly protein SufD; Region: sufD; TIGR01981 357808002224 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 357808002225 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 357808002226 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357808002227 catalytic residue [active] 357808002228 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 357808002229 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 357808002230 trimerization site [polypeptide binding]; other site 357808002231 active site 357808002232 FeS assembly protein SufB; Region: sufB; TIGR01980 357808002233 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 357808002234 Protein of unknown function (DUF497); Region: DUF497; pfam04365 357808002235 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 357808002236 [2Fe-2S] cluster binding site [ion binding]; other site 357808002237 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 357808002238 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 357808002239 active site residue [active] 357808002240 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 357808002241 active site residue [active] 357808002242 Fe-S metabolism associated domain; Region: SufE; cl00951 357808002243 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 357808002244 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 357808002245 trimerization site [polypeptide binding]; other site 357808002246 active site 357808002247 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 357808002248 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 357808002249 dimer interface [polypeptide binding]; other site 357808002250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808002251 catalytic residue [active] 357808002252 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 357808002253 MPN+ (JAMM) motif; other site 357808002254 Zinc-binding site [ion binding]; other site 357808002255 Molybdopterin converting factor, small subunit [Coenzyme metabolism]; Region: MoaD; COG1977 357808002256 charged pocket; other site 357808002257 hydrophobic patch; other site 357808002258 hypothetical protein; Validated; Region: PRK07411 357808002259 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 357808002260 ATP binding site [chemical binding]; other site 357808002261 substrate interface [chemical binding]; other site 357808002262 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 357808002263 active site residue [active] 357808002264 Preprotein translocase SecG subunit; Region: SecG; cl09123 357808002265 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 357808002266 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 357808002267 peptide binding site [polypeptide binding]; other site 357808002268 dimer interface [polypeptide binding]; other site 357808002269 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 357808002270 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 357808002271 active site residue [active] 357808002272 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 357808002273 active site residue [active] 357808002274 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 357808002275 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357808002276 active site 357808002277 HIGH motif; other site 357808002278 nucleotide binding site [chemical binding]; other site 357808002279 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 357808002280 active site 357808002281 KMSKS motif; other site 357808002282 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 357808002283 tRNA binding surface [nucleotide binding]; other site 357808002284 anticodon binding site; other site 357808002285 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808002286 putative active site [active] 357808002287 DNA gyrase subunit A; Validated; Region: PRK05560 357808002288 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 357808002289 CAP-like domain; other site 357808002290 active site 357808002291 primary dimer interface [polypeptide binding]; other site 357808002292 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357808002293 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357808002294 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357808002295 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357808002296 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357808002297 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357808002298 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357808002299 active site 357808002300 metal binding site [ion binding]; metal-binding site 357808002301 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 357808002302 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 357808002303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808002304 ATP binding site [chemical binding]; other site 357808002305 putative Mg++ binding site [ion binding]; other site 357808002306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808002307 nucleotide binding region [chemical binding]; other site 357808002308 ATP-binding site [chemical binding]; other site 357808002309 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808002310 Transposase IS200 like; Region: Y1_Tnp; pfam01797 357808002311 HsdM N-terminal domain; Region: HsdM_N; pfam12161 357808002312 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 357808002313 Methyltransferase domain; Region: Methyltransf_26; pfam13659 357808002314 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 357808002315 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 357808002316 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 357808002317 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 357808002318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808002319 S-adenosylmethionine binding site [chemical binding]; other site 357808002320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808002321 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 357808002322 active site 357808002323 Walker A/P-loop; other site 357808002324 ATP binding site [chemical binding]; other site 357808002325 AAA domain; Region: AAA_21; pfam13304 357808002326 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 357808002327 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 357808002328 Active Sites [active] 357808002329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357808002330 active site 357808002331 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 357808002332 pantoate--beta-alanine ligase; Region: panC; TIGR00018 357808002333 Pantoate-beta-alanine ligase; Region: PanC; cd00560 357808002334 active site 357808002335 ATP-binding site [chemical binding]; other site 357808002336 pantoate-binding site; other site 357808002337 HXXH motif; other site 357808002338 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 357808002339 oligomerization interface [polypeptide binding]; other site 357808002340 active site 357808002341 metal binding site [ion binding]; metal-binding site 357808002342 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 357808002343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357808002344 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357808002345 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 357808002346 active site 357808002347 dimer interface [polypeptide binding]; other site 357808002348 catalytic nucleophile [active] 357808002349 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808002350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808002351 S-adenosylmethionine binding site [chemical binding]; other site 357808002352 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 357808002353 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 357808002354 dimer interface [polypeptide binding]; other site 357808002355 active site 357808002356 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808002357 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808002358 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 357808002359 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 357808002360 NAD binding site [chemical binding]; other site 357808002361 substrate binding site [chemical binding]; other site 357808002362 catalytic Zn binding site [ion binding]; other site 357808002363 tetramer interface [polypeptide binding]; other site 357808002364 structural Zn binding site [ion binding]; other site 357808002365 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 357808002366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808002367 Walker A/P-loop; other site 357808002368 ATP binding site [chemical binding]; other site 357808002369 Q-loop/lid; other site 357808002370 ABC transporter signature motif; other site 357808002371 Walker B; other site 357808002372 D-loop; other site 357808002373 CcmB protein; Region: CcmB; cl17444 357808002374 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 357808002375 CcmE; Region: CcmE; cl00994 357808002376 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 357808002377 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 357808002378 HSP70 interaction site [polypeptide binding]; other site 357808002379 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 357808002380 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357808002381 catalytic residues [active] 357808002382 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808002383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808002384 active site 357808002385 phosphorylation site [posttranslational modification] 357808002386 intermolecular recognition site; other site 357808002387 dimerization interface [polypeptide binding]; other site 357808002388 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808002389 DNA binding site [nucleotide binding] 357808002390 gamma-glutamyl kinase; Provisional; Region: PRK05429 357808002391 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 357808002392 nucleotide binding site [chemical binding]; other site 357808002393 homotetrameric interface [polypeptide binding]; other site 357808002394 putative phosphate binding site [ion binding]; other site 357808002395 putative allosteric binding site; other site 357808002396 PUA domain; Region: PUA; pfam01472 357808002397 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 357808002398 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 357808002399 putative catalytic cysteine [active] 357808002400 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 357808002401 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 357808002402 phosphate binding site [ion binding]; other site 357808002403 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 357808002404 Cytochrome P450; Region: p450; cl12078 357808002405 hypothetical protein; Reviewed; Region: PRK00024 357808002406 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 357808002407 MPN+ (JAMM) motif; other site 357808002408 Zinc-binding site [ion binding]; other site 357808002409 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 357808002410 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 357808002411 VanW like protein; Region: VanW; pfam04294 357808002412 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808002413 active site 357808002414 NTP binding site [chemical binding]; other site 357808002415 metal binding triad [ion binding]; metal-binding site 357808002416 antibiotic binding site [chemical binding]; other site 357808002417 Protein of unknown function DUF86; Region: DUF86; pfam01934 357808002418 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 357808002419 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 357808002420 active site 357808002421 multimer interface [polypeptide binding]; other site 357808002422 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 357808002423 TPR repeat; Region: TPR_11; pfam13414 357808002424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002425 binding surface 357808002426 TPR repeat; Region: TPR_11; pfam13414 357808002427 TPR motif; other site 357808002428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808002429 binding surface 357808002430 Tetratricopeptide repeat; Region: TPR_16; pfam13432 357808002431 TPR motif; other site 357808002432 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 357808002433 hydrophobic ligand binding site; other site 357808002434 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808002435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808002436 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808002437 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 357808002438 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 357808002439 Substrate-binding site [chemical binding]; other site 357808002440 Substrate specificity [chemical binding]; other site 357808002441 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 357808002442 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808002443 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808002444 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808002445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808002446 S-adenosylmethionine binding site [chemical binding]; other site 357808002447 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 357808002448 apolar tunnel; other site 357808002449 heme binding site [chemical binding]; other site 357808002450 dimerization interface [polypeptide binding]; other site 357808002451 FOG: CBS domain [General function prediction only]; Region: COG0517 357808002452 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 357808002453 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 357808002454 isocitrate dehydrogenase; Validated; Region: PRK06451 357808002455 Right handed beta helix region; Region: Beta_helix; pfam13229 357808002456 Right handed beta helix region; Region: Beta_helix; pfam13229 357808002457 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808002458 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808002459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808002460 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808002461 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 357808002462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357808002463 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 357808002464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808002465 Walker A/P-loop; other site 357808002466 ATP binding site [chemical binding]; other site 357808002467 Q-loop/lid; other site 357808002468 ABC transporter signature motif; other site 357808002469 Walker B; other site 357808002470 D-loop; other site 357808002471 H-loop/switch region; other site 357808002472 TOBE domain; Region: TOBE_2; pfam08402 357808002473 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357808002474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808002475 dimer interface [polypeptide binding]; other site 357808002476 conserved gate region; other site 357808002477 putative PBP binding loops; other site 357808002478 ABC-ATPase subunit interface; other site 357808002479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808002480 putative PBP binding loops; other site 357808002481 ABC-ATPase subunit interface; other site 357808002482 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 357808002483 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 357808002484 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 357808002485 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 357808002486 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357808002487 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357808002488 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 357808002489 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 357808002490 Walker A/P-loop; other site 357808002491 ATP binding site [chemical binding]; other site 357808002492 Q-loop/lid; other site 357808002493 ABC transporter signature motif; other site 357808002494 Walker B; other site 357808002495 D-loop; other site 357808002496 H-loop/switch region; other site 357808002497 TOBE domain; Region: TOBE_2; pfam08402 357808002498 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 357808002499 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 357808002500 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357808002501 protein binding site [polypeptide binding]; other site 357808002502 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 357808002503 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357808002504 protein binding site [polypeptide binding]; other site 357808002505 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808002506 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808002507 DNA binding residues [nucleotide binding] 357808002508 dimerization interface [polypeptide binding]; other site 357808002509 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 357808002510 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 357808002511 dimerization interface [polypeptide binding]; other site 357808002512 DPS ferroxidase diiron center [ion binding]; other site 357808002513 ion pore; other site 357808002514 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357808002515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808002516 dimer interface [polypeptide binding]; other site 357808002517 conserved gate region; other site 357808002518 putative PBP binding loops; other site 357808002519 ABC-ATPase subunit interface; other site 357808002520 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357808002521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808002522 ABC-ATPase subunit interface; other site 357808002523 putative PBP binding loops; other site 357808002524 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357808002525 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357808002526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808002527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808002528 dimerization interface [polypeptide binding]; other site 357808002529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808002530 dimer interface [polypeptide binding]; other site 357808002531 phosphorylation site [posttranslational modification] 357808002532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808002533 ATP binding site [chemical binding]; other site 357808002534 Mg2+ binding site [ion binding]; other site 357808002535 G-X-G motif; other site 357808002536 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808002537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808002538 active site 357808002539 phosphorylation site [posttranslational modification] 357808002540 intermolecular recognition site; other site 357808002541 dimerization interface [polypeptide binding]; other site 357808002542 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808002543 DNA binding site [nucleotide binding] 357808002544 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 357808002545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808002546 S-adenosylmethionine binding site [chemical binding]; other site 357808002547 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 357808002548 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808002549 FeS/SAM binding site; other site 357808002550 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 357808002551 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 357808002552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808002553 Walker A/P-loop; other site 357808002554 ATP binding site [chemical binding]; other site 357808002555 Q-loop/lid; other site 357808002556 ABC transporter signature motif; other site 357808002557 Walker B; other site 357808002558 D-loop; other site 357808002559 H-loop/switch region; other site 357808002560 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 357808002561 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 357808002562 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 357808002563 high affinity sulphate transporter 1; Region: sulP; TIGR00815 357808002564 Sulfate transporter family; Region: Sulfate_transp; pfam00916 357808002565 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 357808002566 Putative phosphatase (DUF442); Region: DUF442; cl17385 357808002567 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 357808002568 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 357808002569 CPxP motif; other site 357808002570 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 357808002571 active site residue [active] 357808002572 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357808002573 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808002574 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808002575 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808002576 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 357808002577 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 357808002578 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 357808002579 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 357808002580 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 357808002581 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 357808002582 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808002583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808002584 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808002585 phosphoglyceromutase; Provisional; Region: PRK05434 357808002586 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 357808002587 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 357808002588 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 357808002589 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 357808002590 nucleotide binding region [chemical binding]; other site 357808002591 SEC-C motif; Region: SEC-C; pfam02810 357808002592 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 357808002593 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 357808002594 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 357808002595 Ligand binding site; other site 357808002596 metal-binding site 357808002597 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 357808002598 putative MPT binding site; other site 357808002599 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 357808002600 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 357808002601 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 357808002602 active site 357808002603 catalytic site [active] 357808002604 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 357808002605 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 357808002606 dimer interface [polypeptide binding]; other site 357808002607 ssDNA binding site [nucleotide binding]; other site 357808002608 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357808002609 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 357808002610 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357808002611 NAD binding site [chemical binding]; other site 357808002612 catalytic residues [active] 357808002613 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357808002614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808002615 S-adenosylmethionine binding site [chemical binding]; other site 357808002616 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 357808002617 ParB-like nuclease domain; Region: ParBc; pfam02195 357808002618 Protein of unknown function (DUF497); Region: DUF497; pfam04365 357808002619 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808002620 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808002621 Methylamine utilisation protein MauE; Region: MauE; pfam07291 357808002622 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 357808002623 integron integrase; Region: integrase_gron; TIGR02249 357808002624 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357808002625 active site 357808002626 DNA binding site [nucleotide binding] 357808002627 Int/Topo IB signature motif; other site 357808002628 acetylornithine aminotransferase; Provisional; Region: PRK02627 357808002629 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357808002630 inhibitor-cofactor binding pocket; inhibition site 357808002631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808002632 catalytic residue [active] 357808002633 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 357808002634 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 357808002635 active site 357808002636 metal binding site [ion binding]; metal-binding site 357808002637 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 357808002638 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808002639 active site 357808002640 NTP binding site [chemical binding]; other site 357808002641 metal binding triad [ion binding]; metal-binding site 357808002642 antibiotic binding site [chemical binding]; other site 357808002643 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808002644 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808002645 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808002646 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808002647 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 357808002648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808002649 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808002650 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 357808002651 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 357808002652 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 357808002653 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 357808002654 Predicted membrane protein [Function unknown]; Region: COG3463 357808002655 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808002656 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808002657 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 357808002658 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808002659 PAS domain; Region: PAS_9; pfam13426 357808002660 putative active site [active] 357808002661 heme pocket [chemical binding]; other site 357808002662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808002663 PAS fold; Region: PAS_3; pfam08447 357808002664 putative active site [active] 357808002665 heme pocket [chemical binding]; other site 357808002666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808002667 dimer interface [polypeptide binding]; other site 357808002668 phosphorylation site [posttranslational modification] 357808002669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808002670 ATP binding site [chemical binding]; other site 357808002671 Mg2+ binding site [ion binding]; other site 357808002672 G-X-G motif; other site 357808002673 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357808002674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808002675 active site 357808002676 phosphorylation site [posttranslational modification] 357808002677 intermolecular recognition site; other site 357808002678 dimerization interface [polypeptide binding]; other site 357808002679 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 357808002680 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 357808002681 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 357808002682 Walker A/P-loop; other site 357808002683 ATP binding site [chemical binding]; other site 357808002684 Q-loop/lid; other site 357808002685 ABC transporter signature motif; other site 357808002686 Walker B; other site 357808002687 D-loop; other site 357808002688 H-loop/switch region; other site 357808002689 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 357808002690 putative carbohydrate binding site [chemical binding]; other site 357808002691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 357808002692 DNA-binding site [nucleotide binding]; DNA binding site 357808002693 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357808002694 active site 357808002695 DNA binding site [nucleotide binding] 357808002696 Int/Topo IB signature motif; other site 357808002697 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 357808002698 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357808002699 NAD binding site [chemical binding]; other site 357808002700 substrate binding site [chemical binding]; other site 357808002701 active site 357808002702 glycyl-tRNA synthetase; Provisional; Region: PRK14894 357808002703 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 357808002704 dimer interface [polypeptide binding]; other site 357808002705 motif 1; other site 357808002706 active site 357808002707 motif 2; other site 357808002708 motif 3; other site 357808002709 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 357808002710 anticodon binding site; other site 357808002711 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357808002712 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 357808002713 active site 357808002714 DNA binding site [nucleotide binding] 357808002715 Int/Topo IB signature motif; other site 357808002716 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 357808002717 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 357808002718 FMN binding site [chemical binding]; other site 357808002719 active site 357808002720 catalytic residues [active] 357808002721 substrate binding site [chemical binding]; other site 357808002722 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 357808002723 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 357808002724 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 357808002725 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 357808002726 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 357808002727 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 357808002728 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808002729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808002730 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808002731 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 357808002732 active site 357808002733 Fe-S cluster binding site [ion binding]; other site 357808002734 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 357808002735 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 357808002736 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 357808002737 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 357808002738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808002739 Coenzyme A binding pocket [chemical binding]; other site 357808002740 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 357808002741 PGAP1-like protein; Region: PGAP1; pfam07819 357808002742 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357808002743 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 357808002744 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 357808002745 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 357808002746 active site 357808002747 Substrate binding site; other site 357808002748 Mg++ binding site; other site 357808002749 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 357808002750 AAA domain; Region: AAA_18; pfam13238 357808002751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808002752 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 357808002753 Walker A motif; other site 357808002754 ATP binding site [chemical binding]; other site 357808002755 Walker B motif; other site 357808002756 arginine finger; other site 357808002757 Protein of unknown function (DUF503); Region: DUF503; pfam04456 357808002758 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 357808002759 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 357808002760 heterotetramer interface [polypeptide binding]; other site 357808002761 active site pocket [active] 357808002762 cleavage site 357808002763 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 357808002764 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 357808002765 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 357808002766 putative RNA binding site [nucleotide binding]; other site 357808002767 Methyltransferase domain; Region: Methyltransf_26; pfam13659 357808002768 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 357808002769 WD domain, G-beta repeat; Region: WD40; pfam00400 357808002770 FOG: WD40 repeat [General function prediction only]; Region: COG2319 357808002771 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 357808002772 structural tetrad; other site 357808002773 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 357808002774 structural tetrad; other site 357808002775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 357808002776 Protein of unknown function (DUF433); Region: DUF433; pfam04255 357808002777 short chain dehydrogenase; Provisional; Region: PRK05693 357808002778 Uncharacterized conserved protein [Function unknown]; Region: COG2361 357808002779 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808002780 active site 357808002781 NTP binding site [chemical binding]; other site 357808002782 metal binding triad [ion binding]; metal-binding site 357808002783 antibiotic binding site [chemical binding]; other site 357808002784 Protein of unknown function DUF82; Region: DUF82; pfam01927 357808002785 Methylamine utilisation protein MauE; Region: MauE; pfam07291 357808002786 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 357808002787 putative active site [active] 357808002788 Uncharacterized conserved protein [Function unknown]; Region: COG1262 357808002789 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 357808002790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808002791 AAA domain; Region: AAA_23; pfam13476 357808002792 Walker A/P-loop; other site 357808002793 ATP binding site [chemical binding]; other site 357808002794 Q-loop/lid; other site 357808002795 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 357808002796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808002797 ABC transporter signature motif; other site 357808002798 Walker B; other site 357808002799 D-loop; other site 357808002800 H-loop/switch region; other site 357808002801 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 357808002802 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 357808002803 homodimer interface [polypeptide binding]; other site 357808002804 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 357808002805 active site 357808002806 TDP-binding site; other site 357808002807 acceptor substrate-binding pocket; other site 357808002808 oxidative damage protection protein; Provisional; Region: PRK05408 357808002809 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 357808002810 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 357808002811 hexamer interface [polypeptide binding]; other site 357808002812 ligand binding site [chemical binding]; other site 357808002813 putative active site [active] 357808002814 NAD(P) binding site [chemical binding]; other site 357808002815 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 357808002816 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 357808002817 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 357808002818 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357808002819 Ligand Binding Site [chemical binding]; other site 357808002820 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357808002821 Ligand Binding Site [chemical binding]; other site 357808002822 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357808002823 Ligand Binding Site [chemical binding]; other site 357808002824 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357808002825 Ligand Binding Site [chemical binding]; other site 357808002826 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357808002827 Ligand Binding Site [chemical binding]; other site 357808002828 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 357808002829 FOG: CBS domain [General function prediction only]; Region: COG0517 357808002830 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 357808002831 FOG: CBS domain [General function prediction only]; Region: COG0517 357808002832 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 357808002833 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808002834 putative active site [active] 357808002835 S-adenosylmethionine synthetase; Validated; Region: PRK05250 357808002836 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 357808002837 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 357808002838 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 357808002839 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 357808002840 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 357808002841 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357808002842 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 357808002843 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808002844 motif II; other site 357808002845 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 357808002846 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 357808002847 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357808002848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357808002849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808002850 homodimer interface [polypeptide binding]; other site 357808002851 catalytic residue [active] 357808002852 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808002853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808002854 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808002855 Thymidylate synthase complementing protein; Region: Thy1; cl03630 357808002856 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 357808002857 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 357808002858 active site 357808002859 catalytic triad [active] 357808002860 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 357808002861 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 357808002862 P loop; other site 357808002863 Nucleotide binding site [chemical binding]; other site 357808002864 DTAP/Switch II; other site 357808002865 Switch I; other site 357808002866 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 357808002867 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 357808002868 putative active site [active] 357808002869 homotetrameric interface [polypeptide binding]; other site 357808002870 metal binding site [ion binding]; metal-binding site 357808002871 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 357808002872 Cu(I) binding site [ion binding]; other site 357808002873 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 357808002874 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 357808002875 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 357808002876 Low-spin heme binding site [chemical binding]; other site 357808002877 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 357808002878 D-pathway; other site 357808002879 Putative water exit pathway; other site 357808002880 Binuclear center (active site) [active] 357808002881 K-pathway; other site 357808002882 Putative proton exit pathway; other site 357808002883 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 357808002884 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357808002885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357808002886 non-specific DNA binding site [nucleotide binding]; other site 357808002887 salt bridge; other site 357808002888 sequence-specific DNA binding site [nucleotide binding]; other site 357808002889 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 357808002890 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 357808002891 peptide binding site [polypeptide binding]; other site 357808002892 dimer interface [polypeptide binding]; other site 357808002893 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808002894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808002895 active site 357808002896 phosphorylation site [posttranslational modification] 357808002897 intermolecular recognition site; other site 357808002898 dimerization interface [polypeptide binding]; other site 357808002899 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808002900 DNA binding residues [nucleotide binding] 357808002901 dimerization interface [polypeptide binding]; other site 357808002902 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357808002903 Histidine kinase; Region: HisKA_3; pfam07730 357808002904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808002905 ATP binding site [chemical binding]; other site 357808002906 Mg2+ binding site [ion binding]; other site 357808002907 G-X-G motif; other site 357808002908 V4R domain; Region: V4R; cl15268 357808002909 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 357808002910 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808002911 FeS/SAM binding site; other site 357808002912 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 357808002913 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 357808002914 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 357808002915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808002916 FeS/SAM binding site; other site 357808002917 phytoene desaturase; Region: crtI_fam; TIGR02734 357808002918 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357808002919 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 357808002920 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 357808002921 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 357808002922 putative active site [active] 357808002923 glyoxylate reductase; Reviewed; Region: PRK13243 357808002924 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 357808002925 ligand binding site [chemical binding]; other site 357808002926 NAD binding site [chemical binding]; other site 357808002927 dimerization interface [polypeptide binding]; other site 357808002928 catalytic site [active] 357808002929 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 357808002930 putative active site; other site 357808002931 putative metal binding residues [ion binding]; other site 357808002932 signature motif; other site 357808002933 putative triphosphate binding site [ion binding]; other site 357808002934 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 357808002935 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 357808002936 16S/18S rRNA binding site [nucleotide binding]; other site 357808002937 S13e-L30e interaction site [polypeptide binding]; other site 357808002938 25S rRNA binding site [nucleotide binding]; other site 357808002939 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 357808002940 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 357808002941 RNase E interface [polypeptide binding]; other site 357808002942 trimer interface [polypeptide binding]; other site 357808002943 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 357808002944 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 357808002945 RNase E interface [polypeptide binding]; other site 357808002946 trimer interface [polypeptide binding]; other site 357808002947 active site 357808002948 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 357808002949 putative nucleic acid binding region [nucleotide binding]; other site 357808002950 G-X-X-G motif; other site 357808002951 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 357808002952 RNA binding site [nucleotide binding]; other site 357808002953 domain interface; other site 357808002954 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 357808002955 transmembrane helices; other site 357808002956 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 357808002957 CAAX protease self-immunity; Region: Abi; pfam02517 357808002958 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 357808002959 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 357808002960 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 357808002961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808002962 S-adenosylmethionine binding site [chemical binding]; other site 357808002963 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 357808002964 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357808002965 PYR/PP interface [polypeptide binding]; other site 357808002966 dimer interface [polypeptide binding]; other site 357808002967 TPP binding site [chemical binding]; other site 357808002968 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357808002969 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 357808002970 TPP-binding site; other site 357808002971 dimer interface [polypeptide binding]; other site 357808002972 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 357808002973 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 357808002974 Ligand binding site [chemical binding]; other site 357808002975 Electron transfer flavoprotein domain; Region: ETF; pfam01012 357808002976 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 357808002977 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 357808002978 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 357808002979 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 357808002980 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 357808002981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808002982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808002983 ATP binding site [chemical binding]; other site 357808002984 Mg2+ binding site [ion binding]; other site 357808002985 G-X-G motif; other site 357808002986 Response regulator receiver domain; Region: Response_reg; pfam00072 357808002987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808002988 active site 357808002989 phosphorylation site [posttranslational modification] 357808002990 intermolecular recognition site; other site 357808002991 dimerization interface [polypeptide binding]; other site 357808002992 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 357808002993 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357808002994 Zn2+ binding site [ion binding]; other site 357808002995 Mg2+ binding site [ion binding]; other site 357808002996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357808002997 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808002998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808002999 S-adenosylmethionine binding site [chemical binding]; other site 357808003000 Ras-mediated vulval-induction antagonist; Region: Lin-8; pfam03353 357808003001 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 357808003002 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 357808003003 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 357808003004 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357808003005 active site 357808003006 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 357808003007 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 357808003008 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 357808003009 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 357808003010 Lumazine binding domain; Region: Lum_binding; pfam00677 357808003011 Lumazine binding domain; Region: Lum_binding; pfam00677 357808003012 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 357808003013 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 357808003014 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 357808003015 homopentamer interface [polypeptide binding]; other site 357808003016 active site 357808003017 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 357808003018 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357808003019 HupF/HypC family; Region: HupF_HypC; pfam01455 357808003020 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 357808003021 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 357808003022 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 357808003023 dimerization interface [polypeptide binding]; other site 357808003024 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 357808003025 ATP binding site [chemical binding]; other site 357808003026 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 357808003027 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 357808003028 [2Fe-2S] cluster binding site [ion binding]; other site 357808003029 C-terminal catalytic domain of plant choline monooxygenase (CMO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_CMO-like; cd08883 357808003030 putative alpha subunit interface [polypeptide binding]; other site 357808003031 putative active site [active] 357808003032 putative substrate binding site [chemical binding]; other site 357808003033 Fe binding site [ion binding]; other site 357808003034 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808003035 putative active site [active] 357808003036 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808003037 putative active site [active] 357808003038 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 357808003039 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 357808003040 acyl carrier protein; Provisional; Region: acpP; PRK00982 357808003041 transcription antitermination factor NusB; Region: nusB; TIGR01951 357808003042 putative RNA binding site [nucleotide binding]; other site 357808003043 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 357808003044 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 357808003045 NAD(P) binding site [chemical binding]; other site 357808003046 homotetramer interface [polypeptide binding]; other site 357808003047 homodimer interface [polypeptide binding]; other site 357808003048 active site 357808003049 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 357808003050 Restriction endonuclease; Region: Mrr_cat; pfam04471 357808003051 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 357808003052 ATP cone domain; Region: ATP-cone; pfam03477 357808003053 Uncharacterized conserved protein [Function unknown]; Region: COG4715 357808003054 SWIM zinc finger; Region: SWIM; pfam04434 357808003055 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 357808003056 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 357808003057 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 357808003058 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 357808003059 PhoU domain; Region: PhoU; pfam01895 357808003060 PhoU domain; Region: PhoU; pfam01895 357808003061 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 357808003062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808003063 S-adenosylmethionine binding site [chemical binding]; other site 357808003064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808003065 TPR motif; other site 357808003066 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808003067 binding surface 357808003068 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 357808003069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808003070 active site 357808003071 phosphorylation site [posttranslational modification] 357808003072 intermolecular recognition site; other site 357808003073 dimerization interface [polypeptide binding]; other site 357808003074 CheB methylesterase; Region: CheB_methylest; pfam01339 357808003075 CheW-like domain; Region: CheW; pfam01584 357808003076 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 357808003077 Response regulator receiver domain; Region: Response_reg; pfam00072 357808003078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808003079 active site 357808003080 phosphorylation site [posttranslational modification] 357808003081 intermolecular recognition site; other site 357808003082 dimerization interface [polypeptide binding]; other site 357808003083 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 357808003084 putative binding surface; other site 357808003085 active site 357808003086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808003087 ATP binding site [chemical binding]; other site 357808003088 Mg2+ binding site [ion binding]; other site 357808003089 G-X-G motif; other site 357808003090 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 357808003091 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357808003092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808003093 active site 357808003094 phosphorylation site [posttranslational modification] 357808003095 intermolecular recognition site; other site 357808003096 dimerization interface [polypeptide binding]; other site 357808003097 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 357808003098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808003099 dimerization interface [polypeptide binding]; other site 357808003100 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 357808003101 dimerization interface [polypeptide binding]; other site 357808003102 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357808003103 dimer interface [polypeptide binding]; other site 357808003104 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 357808003105 putative CheW interface [polypeptide binding]; other site 357808003106 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 357808003107 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 357808003108 putative active site [active] 357808003109 catalytic residue [active] 357808003110 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 357808003111 active site 357808003112 catalytic site [active] 357808003113 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 357808003114 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357808003115 catalytic residues [active] 357808003116 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357808003117 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357808003118 catalytic residues [active] 357808003119 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 357808003120 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 357808003121 acyl-activating enzyme (AAE) consensus motif; other site 357808003122 putative AMP binding site [chemical binding]; other site 357808003123 putative active site [active] 357808003124 putative CoA binding site [chemical binding]; other site 357808003125 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 357808003126 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 357808003127 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 357808003128 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 357808003129 minor groove reading motif; other site 357808003130 helix-hairpin-helix signature motif; other site 357808003131 active site 357808003132 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 357808003133 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357808003134 catalytic core [active] 357808003135 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 357808003136 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 357808003137 RNA/DNA hybrid binding site [nucleotide binding]; other site 357808003138 active site 357808003139 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 357808003140 Bacterial transcriptional activator domain; Region: BTAD; smart01043 357808003141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808003142 TPR motif; other site 357808003143 binding surface 357808003144 AAA ATPase domain; Region: AAA_16; pfam13191 357808003145 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808003146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808003147 binding surface 357808003148 TPR motif; other site 357808003149 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 357808003150 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 357808003151 CHAT domain; Region: CHAT; cl17868 357808003152 CHAT domain; Region: CHAT; pfam12770 357808003153 CpXC protein; Region: CpXC; pfam14353 357808003154 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 357808003155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357808003156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357808003157 Walker A motif; other site 357808003158 ATP binding site [chemical binding]; other site 357808003159 WYL domain; Region: WYL; pfam13280 357808003160 Putative transcription activator [Transcription]; Region: TenA; COG0819 357808003161 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 357808003162 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 357808003163 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 357808003164 translation initiation factor IF-3; Region: infC; TIGR00168 357808003165 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 357808003166 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 357808003167 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 357808003168 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 357808003169 23S rRNA binding site [nucleotide binding]; other site 357808003170 L21 binding site [polypeptide binding]; other site 357808003171 L13 binding site [polypeptide binding]; other site 357808003172 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 357808003173 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 357808003174 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 357808003175 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 357808003176 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 357808003177 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 357808003178 dimer interface [polypeptide binding]; other site 357808003179 motif 1; other site 357808003180 active site 357808003181 motif 2; other site 357808003182 motif 3; other site 357808003183 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 357808003184 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 357808003185 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 357808003186 putative tRNA-binding site [nucleotide binding]; other site 357808003187 B3/4 domain; Region: B3_4; pfam03483 357808003188 tRNA synthetase B5 domain; Region: B5; pfam03484 357808003189 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 357808003190 dimer interface [polypeptide binding]; other site 357808003191 motif 1; other site 357808003192 motif 3; other site 357808003193 motif 2; other site 357808003194 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 357808003195 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808003196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808003197 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808003198 lipoyl synthase; Provisional; Region: PRK05481 357808003199 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 357808003200 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 357808003201 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 357808003202 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 357808003203 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 357808003204 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 357808003205 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 357808003206 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 357808003207 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 357808003208 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 357808003209 P loop; other site 357808003210 GTP binding site [chemical binding]; other site 357808003211 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 357808003212 active site 357808003213 catalytic residues [active] 357808003214 metal binding site [ion binding]; metal-binding site 357808003215 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 357808003216 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 357808003217 substrate binding site [chemical binding]; other site 357808003218 ligand binding site [chemical binding]; other site 357808003219 LysE type translocator; Region: LysE; cl00565 357808003220 cystathionine gamma-synthase; Provisional; Region: PRK07811 357808003221 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 357808003222 homodimer interface [polypeptide binding]; other site 357808003223 substrate-cofactor binding pocket; other site 357808003224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808003225 catalytic residue [active] 357808003226 homoaconitate hydratase small subunit; Provisional; Region: PRK14023 357808003227 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 357808003228 substrate binding site [chemical binding]; other site 357808003229 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 357808003230 tartrate dehydrogenase; Region: TTC; TIGR02089 357808003231 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 357808003232 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 357808003233 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357808003234 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 357808003235 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 357808003236 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 357808003237 active site 357808003238 metal binding site [ion binding]; metal-binding site 357808003239 AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251 357808003240 putative nucleotide binding site [chemical binding]; other site 357808003241 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 357808003242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808003243 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357808003244 putative substrate translocation pore; other site 357808003245 pyruvate phosphate dikinase; Provisional; Region: PRK09279 357808003246 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 357808003247 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 357808003248 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 357808003249 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808003250 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808003251 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 357808003252 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 357808003253 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 357808003254 Cna protein B-type domain; Region: Cna_B; pfam05738 357808003255 Cna protein B-type domain; Region: Cna_B; pfam05738 357808003256 Cna protein B-type domain; Region: Cna_B; pfam05738 357808003257 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808003258 putative active site [active] 357808003259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357808003260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357808003261 MFS/sugar transport protein; Region: MFS_2; pfam13347 357808003262 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 357808003263 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 357808003264 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 357808003265 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357808003266 catalytic residue [active] 357808003267 short chain dehydrogenase; Provisional; Region: PRK06180 357808003268 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 357808003269 NADP binding site [chemical binding]; other site 357808003270 active site 357808003271 steroid binding site; other site 357808003272 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 357808003273 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357808003274 PYR/PP interface [polypeptide binding]; other site 357808003275 dimer interface [polypeptide binding]; other site 357808003276 TPP binding site [chemical binding]; other site 357808003277 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357808003278 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 357808003279 TPP-binding site; other site 357808003280 dimer interface [polypeptide binding]; other site 357808003281 hypothetical protein; Provisional; Region: PRK08201 357808003282 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 357808003283 metal binding site [ion binding]; metal-binding site 357808003284 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357808003285 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357808003286 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 357808003287 FtsX-like permease family; Region: FtsX; pfam02687 357808003288 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 357808003289 oligomerisation interface [polypeptide binding]; other site 357808003290 mobile loop; other site 357808003291 roof hairpin; other site 357808003292 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 357808003293 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 357808003294 ring oligomerisation interface [polypeptide binding]; other site 357808003295 ATP/Mg binding site [chemical binding]; other site 357808003296 stacking interactions; other site 357808003297 hinge regions; other site 357808003298 Protein of unknown function (DUF507); Region: DUF507; cl01112 357808003299 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 357808003300 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 357808003301 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 357808003302 glycogen synthase; Provisional; Region: glgA; PRK00654 357808003303 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 357808003304 ADP-binding pocket [chemical binding]; other site 357808003305 homodimer interface [polypeptide binding]; other site 357808003306 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 357808003307 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 357808003308 intersubunit interface [polypeptide binding]; other site 357808003309 active site 357808003310 catalytic residue [active] 357808003311 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808003312 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808003313 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808003314 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 357808003315 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 357808003316 Metal-binding active site; metal-binding site 357808003317 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 357808003318 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 357808003319 Moco binding site; other site 357808003320 metal coordination site [ion binding]; other site 357808003321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808003322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808003323 active site 357808003324 phosphorylation site [posttranslational modification] 357808003325 intermolecular recognition site; other site 357808003326 dimerization interface [polypeptide binding]; other site 357808003327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808003328 DNA binding site [nucleotide binding] 357808003329 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 357808003330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357808003331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808003332 homodimer interface [polypeptide binding]; other site 357808003333 catalytic residue [active] 357808003334 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 357808003335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808003336 S-adenosylmethionine binding site [chemical binding]; other site 357808003337 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 357808003338 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 357808003339 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 357808003340 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 357808003341 protein binding site [polypeptide binding]; other site 357808003342 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 357808003343 Domain interface; other site 357808003344 Peptide binding site; other site 357808003345 Active site tetrad [active] 357808003346 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 357808003347 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 357808003348 peptide binding site [polypeptide binding]; other site 357808003349 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 357808003350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808003351 dimer interface [polypeptide binding]; other site 357808003352 conserved gate region; other site 357808003353 putative PBP binding loops; other site 357808003354 ABC-ATPase subunit interface; other site 357808003355 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 357808003356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808003357 dimer interface [polypeptide binding]; other site 357808003358 conserved gate region; other site 357808003359 putative PBP binding loops; other site 357808003360 ABC-ATPase subunit interface; other site 357808003361 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 357808003362 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 357808003363 Bacterial Ig-like domain; Region: Big_5; pfam13205 357808003364 Bacterial Ig-like domain; Region: Big_5; pfam13205 357808003365 Bacterial Ig-like domain; Region: Big_5; pfam13205 357808003366 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 357808003367 MG2 domain; Region: A2M_N; pfam01835 357808003368 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 357808003369 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 357808003370 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808003371 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 357808003372 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 357808003373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808003374 S-adenosylmethionine binding site [chemical binding]; other site 357808003375 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808003376 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 357808003377 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 357808003378 active site 357808003379 catalytic residues [active] 357808003380 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357808003381 AsnC family; Region: AsnC_trans_reg; pfam01037 357808003382 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 357808003383 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 357808003384 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 357808003385 GatB domain; Region: GatB_Yqey; smart00845 357808003386 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 357808003387 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 357808003388 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 357808003389 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357808003390 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 357808003391 Walker A/P-loop; other site 357808003392 ATP binding site [chemical binding]; other site 357808003393 Q-loop/lid; other site 357808003394 ABC transporter signature motif; other site 357808003395 Walker B; other site 357808003396 D-loop; other site 357808003397 H-loop/switch region; other site 357808003398 Predicted periplasmic protein [Function unknown]; Region: COG3698 357808003399 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 357808003400 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 357808003401 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 357808003402 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 357808003403 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357808003404 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 357808003405 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357808003406 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 357808003407 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 357808003408 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 357808003409 protein binding site [polypeptide binding]; other site 357808003410 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 357808003411 Domain interface; other site 357808003412 Peptide binding site; other site 357808003413 Active site tetrad [active] 357808003414 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 357808003415 putative active site pocket [active] 357808003416 4-fold oligomerization interface [polypeptide binding]; other site 357808003417 metal binding residues [ion binding]; metal-binding site 357808003418 3-fold/trimer interface [polypeptide binding]; other site 357808003419 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 357808003420 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 357808003421 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 357808003422 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 357808003423 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 357808003424 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 357808003425 classical (c) SDRs; Region: SDR_c; cd05233 357808003426 NAD(P) binding site [chemical binding]; other site 357808003427 active site 357808003428 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 357808003429 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 357808003430 acyl-activating enzyme (AAE) consensus motif; other site 357808003431 active site 357808003432 AMP binding site [chemical binding]; other site 357808003433 CoA binding site [chemical binding]; other site 357808003434 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 357808003435 putative active site [active] 357808003436 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 357808003437 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 357808003438 trimer interface [polypeptide binding]; other site 357808003439 active site 357808003440 substrate binding site [chemical binding]; other site 357808003441 CoA binding site [chemical binding]; other site 357808003442 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 357808003443 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 357808003444 Ligand binding site; other site 357808003445 Putative Catalytic site; other site 357808003446 DXD motif; other site 357808003447 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 357808003448 active site 357808003449 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 357808003450 homodimer interface [polypeptide binding]; other site 357808003451 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 357808003452 hypothetical protein; Provisional; Region: PRK07233 357808003453 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 357808003454 Bacterial sugar transferase; Region: Bac_transf; pfam02397 357808003455 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808003456 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808003457 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808003458 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 357808003459 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 357808003460 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 357808003461 putative FMN binding site [chemical binding]; other site 357808003462 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 357808003463 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 357808003464 phosphate binding site [ion binding]; other site 357808003465 dimer interface [polypeptide binding]; other site 357808003466 substrate binding site [chemical binding]; other site 357808003467 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 357808003468 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 357808003469 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 357808003470 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 357808003471 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 357808003472 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 357808003473 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 357808003474 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 357808003475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 357808003476 Uncharacterized conserved protein [Function unknown]; Region: COG1624 357808003477 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 357808003478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 357808003479 TPR motif; other site 357808003480 binding surface 357808003481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808003482 TPR motif; other site 357808003483 binding surface 357808003484 TPR repeat; Region: TPR_11; pfam13414 357808003485 TPR repeat; Region: TPR_11; pfam13414 357808003486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808003487 TPR motif; other site 357808003488 binding surface 357808003489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 357808003490 binding surface 357808003491 TPR motif; other site 357808003492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808003493 binding surface 357808003494 TPR motif; other site 357808003495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808003496 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 357808003497 Walker A motif; other site 357808003498 ATP binding site [chemical binding]; other site 357808003499 Walker B motif; other site 357808003500 arginine finger; other site 357808003501 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 357808003502 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 357808003503 replicative DNA helicase; Region: DnaB; TIGR00665 357808003504 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 357808003505 Walker A motif; other site 357808003506 ATP binding site [chemical binding]; other site 357808003507 Walker B motif; other site 357808003508 DNA binding loops [nucleotide binding] 357808003509 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 357808003510 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 357808003511 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 357808003512 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 357808003513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808003514 motif II; other site 357808003515 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357808003516 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 357808003517 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 357808003518 active site 357808003519 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 357808003520 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 357808003521 23S rRNA interface [nucleotide binding]; other site 357808003522 L3 interface [polypeptide binding]; other site 357808003523 tRNA pseudouridine synthase ACD; Provisional; Region: PRK14588 357808003524 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 357808003525 dimerization interface 3.5A [polypeptide binding]; other site 357808003526 active site 357808003527 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 357808003528 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 357808003529 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 357808003530 alphaNTD homodimer interface [polypeptide binding]; other site 357808003531 alphaNTD - beta interaction site [polypeptide binding]; other site 357808003532 alphaNTD - beta' interaction site [polypeptide binding]; other site 357808003533 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 357808003534 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 357808003535 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 357808003536 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357808003537 RNA binding surface [nucleotide binding]; other site 357808003538 30S ribosomal protein S11; Validated; Region: PRK05309 357808003539 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 357808003540 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 357808003541 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 357808003542 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 357808003543 rRNA binding site [nucleotide binding]; other site 357808003544 predicted 30S ribosome binding site; other site 357808003545 adenylate kinase; Reviewed; Region: adk; PRK00279 357808003546 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 357808003547 AMP-binding site [chemical binding]; other site 357808003548 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 357808003549 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 357808003550 SecY translocase; Region: SecY; pfam00344 357808003551 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 357808003552 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 357808003553 23S rRNA binding site [nucleotide binding]; other site 357808003554 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 357808003555 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 357808003556 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 357808003557 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 357808003558 5S rRNA interface [nucleotide binding]; other site 357808003559 L27 interface [polypeptide binding]; other site 357808003560 23S rRNA interface [nucleotide binding]; other site 357808003561 L5 interface [polypeptide binding]; other site 357808003562 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 357808003563 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 357808003564 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 357808003565 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 357808003566 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 357808003567 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 357808003568 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 357808003569 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 357808003570 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 357808003571 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 357808003572 RNA binding site [nucleotide binding]; other site 357808003573 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 357808003574 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 357808003575 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 357808003576 putative translocon interaction site; other site 357808003577 23S rRNA interface [nucleotide binding]; other site 357808003578 signal recognition particle (SRP54) interaction site; other site 357808003579 L23 interface [polypeptide binding]; other site 357808003580 trigger factor interaction site; other site 357808003581 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 357808003582 23S rRNA interface [nucleotide binding]; other site 357808003583 5S rRNA interface [nucleotide binding]; other site 357808003584 putative antibiotic binding site [chemical binding]; other site 357808003585 L25 interface [polypeptide binding]; other site 357808003586 L27 interface [polypeptide binding]; other site 357808003587 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 357808003588 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 357808003589 G-X-X-G motif; other site 357808003590 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 357808003591 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 357808003592 putative translocon binding site; other site 357808003593 protein-rRNA interface [nucleotide binding]; other site 357808003594 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 357808003595 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 357808003596 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 357808003597 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 357808003598 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 357808003599 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 357808003600 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 357808003601 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 357808003602 elongation factor Tu; Reviewed; Region: PRK00049 357808003603 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 357808003604 G1 box; other site 357808003605 GEF interaction site [polypeptide binding]; other site 357808003606 GTP/Mg2+ binding site [chemical binding]; other site 357808003607 Switch I region; other site 357808003608 G2 box; other site 357808003609 G3 box; other site 357808003610 Switch II region; other site 357808003611 G4 box; other site 357808003612 G5 box; other site 357808003613 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 357808003614 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 357808003615 Antibiotic Binding Site [chemical binding]; other site 357808003616 elongation factor G; Reviewed; Region: PRK00007 357808003617 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 357808003618 G1 box; other site 357808003619 putative GEF interaction site [polypeptide binding]; other site 357808003620 GTP/Mg2+ binding site [chemical binding]; other site 357808003621 Switch I region; other site 357808003622 G2 box; other site 357808003623 G3 box; other site 357808003624 Switch II region; other site 357808003625 G4 box; other site 357808003626 G5 box; other site 357808003627 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 357808003628 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 357808003629 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 357808003630 30S ribosomal protein S7; Validated; Region: PRK05302 357808003631 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 357808003632 S17 interaction site [polypeptide binding]; other site 357808003633 S8 interaction site; other site 357808003634 16S rRNA interaction site [nucleotide binding]; other site 357808003635 streptomycin interaction site [chemical binding]; other site 357808003636 23S rRNA interaction site [nucleotide binding]; other site 357808003637 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 357808003638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357808003639 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 357808003640 Class I aldolases; Region: Aldolase_Class_I; cl17187 357808003641 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808003642 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808003643 DNA binding residues [nucleotide binding] 357808003644 Nitrogenase_MoFe_beta_like: Nitrogenase MoFe protein, beta subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen (N2) to ammonia. This group contains the beta subunits of component 1 of the three known genetically...; Region: Nitrogenase_MoFe_beta_like; cd01965 357808003645 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 357808003646 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 357808003647 Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967 357808003648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808003649 Radical SAM superfamily; Region: Radical_SAM; pfam04055 357808003650 FeS/SAM binding site; other site 357808003651 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 357808003652 nitrogenase iron protein; Region: nifH; TIGR01287 357808003653 Nucleotide-binding sites [chemical binding]; other site 357808003654 Walker A motif; other site 357808003655 Switch I region of nucleotide binding site; other site 357808003656 Fe4S4 binding sites [ion binding]; other site 357808003657 Switch II region of nucleotide binding site; other site 357808003658 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 357808003659 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357808003660 FtsX-like permease family; Region: FtsX; pfam02687 357808003661 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808003662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808003663 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808003664 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 357808003665 active site 357808003666 Transcriptional regulators [Transcription]; Region: MarR; COG1846 357808003667 MarR family; Region: MarR; pfam01047 357808003668 Protoglobin; Region: Protoglobin; pfam11563 357808003669 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 357808003670 Homeobox associated leucine zipper; Region: HALZ; pfam02183 357808003671 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 357808003672 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 357808003673 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 357808003674 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 357808003675 dimer interface [polypeptide binding]; other site 357808003676 PYR/PP interface [polypeptide binding]; other site 357808003677 TPP binding site [chemical binding]; other site 357808003678 substrate binding site [chemical binding]; other site 357808003679 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 357808003680 Domain of unknown function; Region: EKR; pfam10371 357808003681 4Fe-4S binding domain; Region: Fer4_6; pfam12837 357808003682 4Fe-4S binding domain; Region: Fer4; pfam00037 357808003683 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 357808003684 TPP-binding site [chemical binding]; other site 357808003685 dimer interface [polypeptide binding]; other site 357808003686 adenylate kinase; Reviewed; Region: adk; PRK00279 357808003687 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 357808003688 AMP-binding site [chemical binding]; other site 357808003689 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 357808003690 haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562 357808003691 Translin family; Region: Translin; cl00957 357808003692 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357808003693 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 357808003694 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 357808003695 Walker A/P-loop; other site 357808003696 ATP binding site [chemical binding]; other site 357808003697 Q-loop/lid; other site 357808003698 ABC transporter signature motif; other site 357808003699 Walker B; other site 357808003700 D-loop; other site 357808003701 H-loop/switch region; other site 357808003702 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808003703 putative active site [active] 357808003704 deoxyhypusine synthase; Region: dhys; TIGR00321 357808003705 Deoxyhypusine synthase; Region: DS; cl00826 357808003706 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808003707 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808003708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357808003709 dimerization interface [polypeptide binding]; other site 357808003710 putative DNA binding site [nucleotide binding]; other site 357808003711 putative Zn2+ binding site [ion binding]; other site 357808003712 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357808003713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808003714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808003715 putative substrate translocation pore; other site 357808003716 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357808003717 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 357808003718 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 357808003719 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 357808003720 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 357808003721 Low molecular weight phosphatase family; Region: LMWPc; cd00115 357808003722 active site 357808003723 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357808003724 dimerization interface [polypeptide binding]; other site 357808003725 putative DNA binding site [nucleotide binding]; other site 357808003726 putative Zn2+ binding site [ion binding]; other site 357808003727 Low molecular weight phosphatase family; Region: LMWPc; cl00105 357808003728 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 357808003729 active site 357808003730 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 357808003731 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808003732 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808003733 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 357808003734 GIY-YIG motif/motif A; other site 357808003735 putative active site [active] 357808003736 putative metal binding site [ion binding]; other site 357808003737 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 357808003738 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357808003739 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357808003740 ABC transporter; Region: ABC_tran_2; pfam12848 357808003741 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357808003742 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 357808003743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808003744 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357808003745 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357808003746 Walker A/P-loop; other site 357808003747 ATP binding site [chemical binding]; other site 357808003748 Q-loop/lid; other site 357808003749 ABC transporter signature motif; other site 357808003750 Walker B; other site 357808003751 D-loop; other site 357808003752 H-loop/switch region; other site 357808003753 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 357808003754 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 357808003755 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 357808003756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808003757 Coenzyme A binding pocket [chemical binding]; other site 357808003758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808003759 primosomal protein N' Region: priA; TIGR00595 357808003760 ATP binding site [chemical binding]; other site 357808003761 putative Mg++ binding site [ion binding]; other site 357808003762 helicase superfamily c-terminal domain; Region: HELICc; smart00490 357808003763 XamI restriction endonuclease; Region: RE_XamI; pfam09572 357808003764 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 357808003765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808003766 S-adenosylmethionine binding site [chemical binding]; other site 357808003767 CHAT domain; Region: CHAT; cl17868 357808003768 AAA ATPase domain; Region: AAA_16; pfam13191 357808003769 Walker A motif; other site 357808003770 ATP binding site [chemical binding]; other site 357808003771 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992 357808003772 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357808003773 active site 357808003774 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 357808003775 putative trimer interface [polypeptide binding]; other site 357808003776 putative CoA binding site [chemical binding]; other site 357808003777 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 357808003778 Peptidase family M50; Region: Peptidase_M50; pfam02163 357808003779 active site 357808003780 putative substrate binding region [chemical binding]; other site 357808003781 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 357808003782 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 357808003783 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 357808003784 IPT/TIG domain; Region: TIG; pfam01833 357808003785 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 357808003786 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 357808003787 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 357808003788 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 357808003789 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 357808003790 protein binding site [polypeptide binding]; other site 357808003791 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 357808003792 Domain interface; other site 357808003793 Peptide binding site; other site 357808003794 Active site tetrad [active] 357808003795 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 357808003796 active site 357808003797 ribulose/triose binding site [chemical binding]; other site 357808003798 phosphate binding site [ion binding]; other site 357808003799 substrate (anthranilate) binding pocket [chemical binding]; other site 357808003800 product (indole) binding pocket [chemical binding]; other site 357808003801 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 357808003802 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 357808003803 amidase; Provisional; Region: PRK07486 357808003804 Amidase; Region: Amidase; pfam01425 357808003805 oligoendopeptidase F; Region: pepF; TIGR00181 357808003806 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 357808003807 active site 357808003808 Zn binding site [ion binding]; other site 357808003809 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 357808003810 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357808003811 ABC-ATPase subunit interface; other site 357808003812 dimer interface [polypeptide binding]; other site 357808003813 putative PBP binding regions; other site 357808003814 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 357808003815 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 357808003816 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 357808003817 intersubunit interface [polypeptide binding]; other site 357808003818 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 357808003819 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 357808003820 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808003821 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808003822 active site 357808003823 ATP binding site [chemical binding]; other site 357808003824 substrate binding site [chemical binding]; other site 357808003825 Bacterial SH3 domain; Region: SH3_3; pfam08239 357808003826 NAD-dependent deacetylase; Provisional; Region: PRK00481 357808003827 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 357808003828 NAD+ binding site [chemical binding]; other site 357808003829 substrate binding site [chemical binding]; other site 357808003830 Zn binding site [ion binding]; other site 357808003831 NAD-dependent deacetylase; Provisional; Region: PRK00481 357808003832 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 357808003833 NAD+ binding site [chemical binding]; other site 357808003834 substrate binding site [chemical binding]; other site 357808003835 Zn binding site [ion binding]; other site 357808003836 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357808003837 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357808003838 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 357808003839 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 357808003840 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 357808003841 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 357808003842 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 357808003843 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 357808003844 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 357808003845 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 357808003846 G-loop; other site 357808003847 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 357808003848 DNA binding site [nucleotide binding] 357808003849 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 357808003850 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 357808003851 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 357808003852 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 357808003853 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 357808003854 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 357808003855 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 357808003856 RPB12 interaction site [polypeptide binding]; other site 357808003857 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 357808003858 RPB10 interaction site [polypeptide binding]; other site 357808003859 RPB1 interaction site [polypeptide binding]; other site 357808003860 RPB11 interaction site [polypeptide binding]; other site 357808003861 RPB3 interaction site [polypeptide binding]; other site 357808003862 RPB12 interaction site [polypeptide binding]; other site 357808003863 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 357808003864 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 357808003865 Response regulator receiver domain; Region: Response_reg; pfam00072 357808003866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808003867 active site 357808003868 phosphorylation site [posttranslational modification] 357808003869 intermolecular recognition site; other site 357808003870 dimerization interface [polypeptide binding]; other site 357808003871 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 357808003872 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 357808003873 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 357808003874 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 357808003875 ATP binding site [chemical binding]; other site 357808003876 Walker A motif; other site 357808003877 hexamer interface [polypeptide binding]; other site 357808003878 Walker B motif; other site 357808003879 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 357808003880 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357808003881 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 357808003882 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357808003883 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 357808003884 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 357808003885 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357808003886 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357808003887 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357808003888 rod shape-determining protein MreC; Provisional; Region: PRK13922 357808003889 rod shape-determining protein MreC; Region: MreC; pfam04085 357808003890 rod shape-determining protein MreB; Provisional; Region: PRK13927 357808003891 MreB and similar proteins; Region: MreB_like; cd10225 357808003892 nucleotide binding site [chemical binding]; other site 357808003893 Mg binding site [ion binding]; other site 357808003894 putative protofilament interaction site [polypeptide binding]; other site 357808003895 RodZ interaction site [polypeptide binding]; other site 357808003896 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357808003897 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357808003898 Walker A/P-loop; other site 357808003899 ATP binding site [chemical binding]; other site 357808003900 Q-loop/lid; other site 357808003901 ABC transporter signature motif; other site 357808003902 Walker B; other site 357808003903 D-loop; other site 357808003904 H-loop/switch region; other site 357808003905 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 357808003906 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 357808003907 signal recognition particle protein; Provisional; Region: PRK10867 357808003908 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 357808003909 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 357808003910 P loop; other site 357808003911 GTP binding site [chemical binding]; other site 357808003912 Signal peptide binding domain; Region: SRP_SPB; pfam02978 357808003913 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 357808003914 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 357808003915 KH domain; Region: KH_4; pfam13083 357808003916 G-X-X-G motif; other site 357808003917 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 357808003918 RimM N-terminal domain; Region: RimM; pfam01782 357808003919 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 357808003920 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357808003921 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357808003922 active site 357808003923 Thioredoxin; Region: Thioredoxin_4; pfam13462 357808003924 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 357808003925 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 357808003926 metal binding site 2 [ion binding]; metal-binding site 357808003927 putative DNA binding helix; other site 357808003928 metal binding site 1 [ion binding]; metal-binding site 357808003929 dimer interface [polypeptide binding]; other site 357808003930 structural Zn2+ binding site [ion binding]; other site 357808003931 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 357808003932 putative active site [active] 357808003933 putative CoA binding site [chemical binding]; other site 357808003934 nudix motif; other site 357808003935 metal binding site [ion binding]; metal-binding site 357808003936 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 357808003937 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 357808003938 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 357808003939 active site 357808003940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 357808003941 purine nucleoside phosphorylase; Provisional; Region: PRK08202 357808003942 Bacterial PH domain; Region: DUF304; pfam03703 357808003943 Short C-terminal domain; Region: SHOCT; pfam09851 357808003944 Recombination protein O N terminal; Region: RecO_N; pfam11967 357808003945 DNA repair protein RecO; Region: reco; TIGR00613 357808003946 Recombination protein O C terminal; Region: RecO_C; pfam02565 357808003947 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 357808003948 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 357808003949 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 357808003950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808003951 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808003952 DNA binding residues [nucleotide binding] 357808003953 GTP-binding protein YchF; Reviewed; Region: PRK09601 357808003954 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 357808003955 G1 box; other site 357808003956 GTP/Mg2+ binding site [chemical binding]; other site 357808003957 G2 box; other site 357808003958 Switch I region; other site 357808003959 G3 box; other site 357808003960 Switch II region; other site 357808003961 G4 box; other site 357808003962 G5 box; other site 357808003963 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 357808003964 cell division protein FtsW; Region: ftsW; TIGR02614 357808003965 Response regulator receiver domain; Region: Response_reg; pfam00072 357808003966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808003967 active site 357808003968 phosphorylation site [posttranslational modification] 357808003969 intermolecular recognition site; other site 357808003970 dimerization interface [polypeptide binding]; other site 357808003971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808003972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808003973 dimer interface [polypeptide binding]; other site 357808003974 phosphorylation site [posttranslational modification] 357808003975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808003976 ATP binding site [chemical binding]; other site 357808003977 Mg2+ binding site [ion binding]; other site 357808003978 G-X-G motif; other site 357808003979 Cache domain; Region: Cache_1; pfam02743 357808003980 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 357808003981 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808003982 dimerization interface [polypeptide binding]; other site 357808003983 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808003984 GAF domain; Region: GAF_3; pfam13492 357808003985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808003986 dimer interface [polypeptide binding]; other site 357808003987 phosphorylation site [posttranslational modification] 357808003988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808003989 ATP binding site [chemical binding]; other site 357808003990 Mg2+ binding site [ion binding]; other site 357808003991 G-X-G motif; other site 357808003992 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 357808003993 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 357808003994 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357808003995 active site 357808003996 HIGH motif; other site 357808003997 nucleotide binding site [chemical binding]; other site 357808003998 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 357808003999 KMSK motif region; other site 357808004000 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 357808004001 tRNA binding surface [nucleotide binding]; other site 357808004002 anticodon binding site; other site 357808004003 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 357808004004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808004005 active site 357808004006 motif I; other site 357808004007 motif II; other site 357808004008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808004009 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 357808004010 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 357808004011 active site 357808004012 Divergent AAA domain; Region: AAA_4; pfam04326 357808004013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 357808004014 binding surface 357808004015 TPR motif; other site 357808004016 THUMP domain, predicted to bind RNA; Region: THUMP; cl12076 357808004017 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 357808004018 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 357808004019 active site 357808004020 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 357808004021 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357808004022 Walker A/P-loop; other site 357808004023 ATP binding site [chemical binding]; other site 357808004024 Q-loop/lid; other site 357808004025 ABC transporter signature motif; other site 357808004026 Walker B; other site 357808004027 D-loop; other site 357808004028 H-loop/switch region; other site 357808004029 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357808004030 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357808004031 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 357808004032 TM-ABC transporter signature motif; other site 357808004033 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357808004034 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 357808004035 TM-ABC transporter signature motif; other site 357808004036 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 357808004037 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 357808004038 ligand binding site [chemical binding]; other site 357808004039 FOG: WD40 repeat [General function prediction only]; Region: COG2319 357808004040 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 357808004041 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 357808004042 oligomerisation interface [polypeptide binding]; other site 357808004043 mobile loop; other site 357808004044 roof hairpin; other site 357808004045 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 357808004046 catalytic residues [active] 357808004047 DDE superfamily endonuclease; Region: DDE_3; pfam13358 357808004048 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808004049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808004050 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808004051 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 357808004052 putative active site [active] 357808004053 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 357808004054 nudix motif; other site 357808004055 Putative phosphatase (DUF442); Region: DUF442; cl17385 357808004056 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 357808004057 NAD(P) binding pocket [chemical binding]; other site 357808004058 GTP-binding protein LepA; Provisional; Region: PRK05433 357808004059 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 357808004060 G1 box; other site 357808004061 putative GEF interaction site [polypeptide binding]; other site 357808004062 GTP/Mg2+ binding site [chemical binding]; other site 357808004063 Switch I region; other site 357808004064 G2 box; other site 357808004065 G3 box; other site 357808004066 Switch II region; other site 357808004067 G4 box; other site 357808004068 G5 box; other site 357808004069 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 357808004070 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 357808004071 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 357808004072 SurA N-terminal domain; Region: SurA_N; pfam09312 357808004073 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 357808004074 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 357808004075 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 357808004076 putative SAM binding site [chemical binding]; other site 357808004077 putative homodimer interface [polypeptide binding]; other site 357808004078 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 357808004079 homodimer interface [polypeptide binding]; other site 357808004080 metal binding site [ion binding]; metal-binding site 357808004081 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 357808004082 homodimer interface [polypeptide binding]; other site 357808004083 active site 357808004084 putative chemical substrate binding site [chemical binding]; other site 357808004085 metal binding site [ion binding]; metal-binding site 357808004086 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 357808004087 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 357808004088 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 357808004089 dimer interface [polypeptide binding]; other site 357808004090 active site residues [active] 357808004091 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 357808004092 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 357808004093 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 357808004094 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808004095 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 357808004096 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808004097 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 357808004098 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 357808004099 AIR carboxylase; Region: AIRC; smart01001 357808004100 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 357808004101 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 357808004102 Ligand Binding Site [chemical binding]; other site 357808004103 Peptidase family M23; Region: Peptidase_M23; pfam01551 357808004104 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 357808004105 catalytic residues [active] 357808004106 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 357808004107 oligomerisation interface [polypeptide binding]; other site 357808004108 mobile loop; other site 357808004109 roof hairpin; other site 357808004110 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 357808004111 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 357808004112 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 357808004113 ornithine cyclodeaminase; Validated; Region: PRK08618 357808004114 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 357808004115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808004116 NAD(P) binding site [chemical binding]; other site 357808004117 active site 357808004118 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 357808004119 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 357808004120 active site pocket [active] 357808004121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357808004122 DNA-binding site [nucleotide binding]; DNA binding site 357808004123 Predicted transcriptional regulators [Transcription]; Region: COG1725 357808004124 Melibiase; Region: Melibiase; pfam02065 357808004125 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357808004126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808004127 putative PBP binding loops; other site 357808004128 dimer interface [polypeptide binding]; other site 357808004129 ABC-ATPase subunit interface; other site 357808004130 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357808004131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808004132 dimer interface [polypeptide binding]; other site 357808004133 conserved gate region; other site 357808004134 putative PBP binding loops; other site 357808004135 ABC-ATPase subunit interface; other site 357808004136 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357808004137 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357808004138 Melibiase; Region: Melibiase; pfam02065 357808004139 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 357808004140 active site 357808004141 catalytic residues [active] 357808004142 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 357808004143 classical (c) SDRs; Region: SDR_c; cd05233 357808004144 NAD(P) binding site [chemical binding]; other site 357808004145 active site 357808004146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808004147 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357808004148 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 357808004149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357808004150 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808004151 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808004152 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808004153 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808004154 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808004155 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808004156 Rdx family; Region: Rdx; pfam10262 357808004157 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 357808004158 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 357808004159 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 357808004160 TPP-binding site [chemical binding]; other site 357808004161 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 357808004162 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 357808004163 dimer interface [polypeptide binding]; other site 357808004164 PYR/PP interface [polypeptide binding]; other site 357808004165 TPP binding site [chemical binding]; other site 357808004166 substrate binding site [chemical binding]; other site 357808004167 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 357808004168 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 357808004169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808004170 Radical SAM superfamily; Region: Radical_SAM; pfam04055 357808004171 FeS/SAM binding site; other site 357808004172 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 357808004173 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 357808004174 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 357808004175 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14461 357808004176 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 357808004177 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357808004178 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357808004179 catalytic residue [active] 357808004180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357808004181 Histidine kinase; Region: HisKA_3; pfam07730 357808004182 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 357808004183 active site 357808004184 catalytic triad [active] 357808004185 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357808004186 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357808004187 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 357808004188 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808004189 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808004190 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 357808004191 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 357808004192 metal ion-dependent adhesion site (MIDAS); other site 357808004193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808004194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808004195 active site 357808004196 phosphorylation site [posttranslational modification] 357808004197 intermolecular recognition site; other site 357808004198 dimerization interface [polypeptide binding]; other site 357808004199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808004200 DNA binding site [nucleotide binding] 357808004201 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 357808004202 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357808004203 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 357808004204 RDD family; Region: RDD; pfam06271 357808004205 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 357808004206 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357808004207 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 357808004208 active site 357808004209 catalytic tetrad [active] 357808004210 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808004211 putative active site [active] 357808004212 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808004213 putative active site [active] 357808004214 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357808004215 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 357808004216 Ligand binding site; other site 357808004217 Ligand binding site; other site 357808004218 Ligand binding site; other site 357808004219 Putative Catalytic site; other site 357808004220 DXD motif; other site 357808004221 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 357808004222 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357808004223 Probable Catalytic site; other site 357808004224 metal-binding site 357808004225 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 357808004226 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 357808004227 NADP binding site [chemical binding]; other site 357808004228 active site 357808004229 putative substrate binding site [chemical binding]; other site 357808004230 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 357808004231 hypothetical protein; Provisional; Region: PRK08201 357808004232 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 357808004233 metal binding site [ion binding]; metal-binding site 357808004234 putative dimer interface [polypeptide binding]; other site 357808004235 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 357808004236 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357808004237 substrate binding pocket [chemical binding]; other site 357808004238 membrane-bound complex binding site; other site 357808004239 hinge residues; other site 357808004240 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 357808004241 PemK-like protein; Region: PemK; pfam02452 357808004242 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 357808004243 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 357808004244 domain interfaces; other site 357808004245 active site 357808004246 SLBB domain; Region: SLBB; pfam10531 357808004247 comEA protein; Region: comE; TIGR01259 357808004248 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 357808004249 DNA topoisomerase I; Validated; Region: PRK06599 357808004250 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 357808004251 active site 357808004252 interdomain interaction site; other site 357808004253 putative metal-binding site [ion binding]; other site 357808004254 nucleotide binding site [chemical binding]; other site 357808004255 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 357808004256 domain I; other site 357808004257 DNA binding groove [nucleotide binding] 357808004258 phosphate binding site [ion binding]; other site 357808004259 domain II; other site 357808004260 domain III; other site 357808004261 nucleotide binding site [chemical binding]; other site 357808004262 catalytic site [active] 357808004263 domain IV; other site 357808004264 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 357808004265 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 357808004266 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 357808004267 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 357808004268 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 357808004269 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 357808004270 active site 357808004271 metal binding site [ion binding]; metal-binding site 357808004272 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 357808004273 active site 357808004274 catalytic site [active] 357808004275 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 357808004276 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 357808004277 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 357808004278 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 357808004279 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 357808004280 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 357808004281 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 357808004282 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 357808004283 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 357808004284 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741 357808004285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808004286 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808004287 active site 357808004288 NTP binding site [chemical binding]; other site 357808004289 metal binding triad [ion binding]; metal-binding site 357808004290 antibiotic binding site [chemical binding]; other site 357808004291 HEPN domain; Region: HEPN; pfam05168 357808004292 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 357808004293 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 357808004294 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 357808004295 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 357808004296 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 357808004297 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 357808004298 glutamine binding [chemical binding]; other site 357808004299 catalytic triad [active] 357808004300 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 357808004301 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 357808004302 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 357808004303 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 357808004304 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 357808004305 active site 357808004306 HIGH motif; other site 357808004307 dimer interface [polypeptide binding]; other site 357808004308 KMSKS motif; other site 357808004309 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 357808004310 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 357808004311 AP (apurinic/apyrimidinic) site pocket; other site 357808004312 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 357808004313 DNA interaction; other site 357808004314 Metal-binding active site; metal-binding site 357808004315 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 357808004316 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 357808004317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808004318 catalytic residue [active] 357808004319 Repair protein; Region: Repair_PSII; pfam04536 357808004320 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808004321 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808004322 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808004323 phosphopeptide binding site; other site 357808004324 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 357808004325 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 357808004326 metal ion-dependent adhesion site (MIDAS); other site 357808004327 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 357808004328 active site 357808004329 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808004330 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808004331 active site 357808004332 ATP binding site [chemical binding]; other site 357808004333 substrate binding site [chemical binding]; other site 357808004334 activation loop (A-loop); other site 357808004335 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 357808004336 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 357808004337 Trp docking motif [polypeptide binding]; other site 357808004338 active site 357808004339 Bacterial SH3 domain; Region: SH3_3; cl17532 357808004340 Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277 357808004341 WYL domain; Region: WYL; pfam13280 357808004342 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 357808004343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808004344 Walker A motif; other site 357808004345 ATP binding site [chemical binding]; other site 357808004346 Walker B motif; other site 357808004347 arginine finger; other site 357808004348 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 357808004349 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 357808004350 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808004351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808004352 DNA binding residues [nucleotide binding] 357808004353 Phosphoglycerate kinase; Region: PGK; pfam00162 357808004354 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 357808004355 substrate binding site [chemical binding]; other site 357808004356 hinge regions; other site 357808004357 ADP binding site [chemical binding]; other site 357808004358 catalytic site [active] 357808004359 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 357808004360 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 357808004361 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808004362 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808004363 Methyltransferase domain; Region: Methyltransf_26; pfam13659 357808004364 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 357808004365 PLD-like domain; Region: PLDc_2; pfam13091 357808004366 putative homodimer interface [polypeptide binding]; other site 357808004367 putative active site [active] 357808004368 catalytic site [active] 357808004369 DEAD-like helicases superfamily; Region: DEXDc; smart00487 357808004370 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808004371 putative Mg++ binding site [ion binding]; other site 357808004372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808004373 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 357808004374 nucleotide binding region [chemical binding]; other site 357808004375 ATP-binding site [chemical binding]; other site 357808004376 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 357808004377 classical (c) SDRs; Region: SDR_c; cd05233 357808004378 NAD(P) binding site [chemical binding]; other site 357808004379 active site 357808004380 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357808004381 active site 357808004382 nucleotide binding site [chemical binding]; other site 357808004383 HIGH motif; other site 357808004384 KMSKS motif; other site 357808004385 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 357808004386 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 357808004387 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 357808004388 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 357808004389 NADP binding site [chemical binding]; other site 357808004390 dimer interface [polypeptide binding]; other site 357808004391 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 357808004392 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 357808004393 active site 357808004394 catalytic site [active] 357808004395 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 357808004396 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 357808004397 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 357808004398 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 357808004399 active site residue [active] 357808004400 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 357808004401 active site residue [active] 357808004402 Sulphur transport; Region: Sulf_transp; pfam04143 357808004403 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 357808004404 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 357808004405 active site 357808004406 catalytic triad [active] 357808004407 dimer interface [polypeptide binding]; other site 357808004408 NurA nuclease; Region: NurA; smart00933 357808004409 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 357808004410 UbiA prenyltransferase family; Region: UbiA; pfam01040 357808004411 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 357808004412 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 357808004413 homotrimer interaction site [polypeptide binding]; other site 357808004414 putative active site [active] 357808004415 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 357808004416 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 357808004417 conserved cys residue [active] 357808004418 Cytochrome c; Region: Cytochrom_C; cl11414 357808004419 CopC domain; Region: CopC; pfam04234 357808004420 Copper resistance protein D; Region: CopD; cl00563 357808004421 CopC domain; Region: CopC; pfam04234 357808004422 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 357808004423 TMAO/DMSO reductase; Reviewed; Region: PRK05363 357808004424 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 357808004425 Moco binding site; other site 357808004426 metal coordination site [ion binding]; other site 357808004427 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 357808004428 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 357808004429 dimer interface [polypeptide binding]; other site 357808004430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808004431 catalytic residue [active] 357808004432 CpXC protein; Region: CpXC; pfam14353 357808004433 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 357808004434 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 357808004435 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 357808004436 NAD binding site [chemical binding]; other site 357808004437 homodimer interface [polypeptide binding]; other site 357808004438 active site 357808004439 substrate binding site [chemical binding]; other site 357808004440 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808004441 dimerization interface [polypeptide binding]; other site 357808004442 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 357808004443 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808004444 dimerization interface [polypeptide binding]; other site 357808004445 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357808004446 dimer interface [polypeptide binding]; other site 357808004447 putative CheW interface [polypeptide binding]; other site 357808004448 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808004449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808004450 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808004451 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 357808004452 Bacterial transcriptional activator domain; Region: BTAD; smart01043 357808004453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808004454 binding surface 357808004455 TPR motif; other site 357808004456 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 357808004457 active site 357808004458 catalytic triad [active] 357808004459 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 357808004460 PA/protease or protease-like domain interface [polypeptide binding]; other site 357808004461 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 357808004462 catalytic residues [active] 357808004463 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 357808004464 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 357808004465 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 357808004466 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808004467 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808004468 active site 357808004469 ATP binding site [chemical binding]; other site 357808004470 substrate binding site [chemical binding]; other site 357808004471 activation loop (A-loop); other site 357808004472 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808004473 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808004474 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808004475 phosphopeptide binding site; other site 357808004476 Clostripain family; Region: Peptidase_C11; pfam03415 357808004477 glutamate racemase; Provisional; Region: PRK00865 357808004478 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 357808004479 tetramer interface [polypeptide binding]; other site 357808004480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808004481 catalytic residue [active] 357808004482 Phosphotransferase enzyme family; Region: APH; pfam01636 357808004483 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 357808004484 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 357808004485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808004486 tetramer interface [polypeptide binding]; other site 357808004487 catalytic residue [active] 357808004488 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 357808004489 lipoyl attachment site [posttranslational modification]; other site 357808004490 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 357808004491 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 357808004492 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 357808004493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808004494 Response regulator receiver domain; Region: Response_reg; pfam00072 357808004495 active site 357808004496 phosphorylation site [posttranslational modification] 357808004497 intermolecular recognition site; other site 357808004498 dimerization interface [polypeptide binding]; other site 357808004499 Helix-turn-helix domain; Region: HTH_25; pfam13413 357808004500 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808004501 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808004502 active site 357808004503 ATP binding site [chemical binding]; other site 357808004504 substrate binding site [chemical binding]; other site 357808004505 activation loop (A-loop); other site 357808004506 Domain of unknown function (DUF3524); Region: DUF3524; pfam12038 357808004507 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808004508 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808004509 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808004510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808004511 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808004512 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 357808004513 recombination protein RecR; Reviewed; Region: recR; PRK00076 357808004514 RecR protein; Region: RecR; pfam02132 357808004515 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 357808004516 putative active site [active] 357808004517 putative metal-binding site [ion binding]; other site 357808004518 tetramer interface [polypeptide binding]; other site 357808004519 hypothetical protein; Validated; Region: PRK00153 357808004520 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 357808004521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808004522 Walker A motif; other site 357808004523 ATP binding site [chemical binding]; other site 357808004524 Walker B motif; other site 357808004525 arginine finger; other site 357808004526 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 357808004527 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 357808004528 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 357808004529 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 357808004530 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 357808004531 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 357808004532 Walker A/P-loop; other site 357808004533 ATP binding site [chemical binding]; other site 357808004534 Q-loop/lid; other site 357808004535 ABC transporter signature motif; other site 357808004536 Walker B; other site 357808004537 D-loop; other site 357808004538 H-loop/switch region; other site 357808004539 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 357808004540 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 357808004541 Walker A/P-loop; other site 357808004542 ATP binding site [chemical binding]; other site 357808004543 Q-loop/lid; other site 357808004544 ABC transporter signature motif; other site 357808004545 Walker B; other site 357808004546 D-loop; other site 357808004547 H-loop/switch region; other site 357808004548 Putative cyclase; Region: Cyclase; pfam04199 357808004549 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 357808004550 TM-ABC transporter signature motif; other site 357808004551 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 357808004552 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 357808004553 putative ligand binding site [chemical binding]; other site 357808004554 Transcriptional regulators [Transcription]; Region: GntR; COG1802 357808004555 FCD domain; Region: FCD; pfam07729 357808004556 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 357808004557 Asp-box motif; other site 357808004558 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 357808004559 Asp-box motif; other site 357808004560 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 357808004561 Asp-box motif; other site 357808004562 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 357808004563 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 357808004564 Glutamate binding site [chemical binding]; other site 357808004565 homodimer interface [polypeptide binding]; other site 357808004566 NAD binding site [chemical binding]; other site 357808004567 catalytic residues [active] 357808004568 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 357808004569 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 357808004570 active site 357808004571 Zn binding site [ion binding]; other site 357808004572 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 357808004573 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 357808004574 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 357808004575 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 357808004576 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 357808004577 dimer interface [polypeptide binding]; other site 357808004578 PYR/PP interface [polypeptide binding]; other site 357808004579 TPP binding site [chemical binding]; other site 357808004580 substrate binding site [chemical binding]; other site 357808004581 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 357808004582 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 357808004583 TPP-binding site [chemical binding]; other site 357808004584 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 357808004585 Clp protease; Region: CLP_protease; pfam00574 357808004586 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 357808004587 oligomer interface [polypeptide binding]; other site 357808004588 active site residues [active] 357808004589 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357808004590 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 357808004591 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 357808004592 NAD binding site [chemical binding]; other site 357808004593 homotetramer interface [polypeptide binding]; other site 357808004594 homodimer interface [polypeptide binding]; other site 357808004595 substrate binding site [chemical binding]; other site 357808004596 active site 357808004597 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 357808004598 Domain of unknown function DUF20; Region: UPF0118; pfam01594 357808004599 cell division topological specificity factor MinE; Provisional; Region: PRK13991 357808004600 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 357808004601 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 357808004602 Switch I; other site 357808004603 Switch II; other site 357808004604 septum formation inhibitor; Reviewed; Region: minC; PRK00513 357808004605 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 357808004606 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 357808004607 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357808004608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808004609 homodimer interface [polypeptide binding]; other site 357808004610 catalytic residue [active] 357808004611 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 357808004612 Flavoprotein; Region: Flavoprotein; pfam02441 357808004613 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 357808004614 HEAT repeats; Region: HEAT_2; pfam13646 357808004615 YceG-like family; Region: YceG; pfam02618 357808004616 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 357808004617 dimerization interface [polypeptide binding]; other site 357808004618 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 357808004619 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 357808004620 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 357808004621 shikimate binding site; other site 357808004622 NAD(P) binding site [chemical binding]; other site 357808004623 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 357808004624 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 357808004625 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 357808004626 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 357808004627 catalytic triad [active] 357808004628 putative active site [active] 357808004629 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 357808004630 Uncharacterized conserved protein [Function unknown]; Region: COG3743 357808004631 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 357808004632 enterobactin exporter EntS; Provisional; Region: PRK10489 357808004633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808004634 putative substrate translocation pore; other site 357808004635 large T antigen; Provisional; Region: PHA02624 357808004636 4-alpha-glucanotransferase; Provisional; Region: PRK14508 357808004637 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 357808004638 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 357808004639 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 357808004640 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 357808004641 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 357808004642 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357808004643 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357808004644 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 357808004645 substrate binding site [chemical binding]; other site 357808004646 ATP binding site [chemical binding]; other site 357808004647 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 357808004648 active site 357808004649 intersubunit interface [polypeptide binding]; other site 357808004650 Zn2+ binding site [ion binding]; other site 357808004651 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 357808004652 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357808004653 ATP-dependent DNA ligase; Validated; Region: PRK09247 357808004654 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 357808004655 active site 357808004656 DNA binding site [nucleotide binding] 357808004657 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 357808004658 DNA binding site [nucleotide binding] 357808004659 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 357808004660 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 357808004661 putative active site [active] 357808004662 Zn binding site [ion binding]; other site 357808004663 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 357808004664 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357808004665 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 357808004666 active site 357808004667 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 357808004668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808004669 Walker A/P-loop; other site 357808004670 ATP binding site [chemical binding]; other site 357808004671 Q-loop/lid; other site 357808004672 ABC transporter signature motif; other site 357808004673 Walker B; other site 357808004674 D-loop; other site 357808004675 H-loop/switch region; other site 357808004676 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357808004677 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 357808004678 Walker A/P-loop; other site 357808004679 ATP binding site [chemical binding]; other site 357808004680 Q-loop/lid; other site 357808004681 ABC transporter signature motif; other site 357808004682 Walker B; other site 357808004683 D-loop; other site 357808004684 H-loop/switch region; other site 357808004685 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357808004686 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 357808004687 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 357808004688 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 357808004689 phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293 357808004690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357808004691 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 357808004692 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 357808004693 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 357808004694 Walker A/P-loop; other site 357808004695 ATP binding site [chemical binding]; other site 357808004696 Q-loop/lid; other site 357808004697 ABC transporter signature motif; other site 357808004698 Walker B; other site 357808004699 D-loop; other site 357808004700 H-loop/switch region; other site 357808004701 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 357808004702 RDD family; Region: RDD; pfam06271 357808004703 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 357808004704 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357808004705 catalytic core [active] 357808004706 HicB family; Region: HicB; pfam05534 357808004707 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 357808004708 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357808004709 active site 357808004710 SEC-C motif; Region: SEC-C; pfam02810 357808004711 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 357808004712 CoA-transferase family III; Region: CoA_transf_3; pfam02515 357808004713 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 357808004714 Phosphotransferase enzyme family; Region: APH; pfam01636 357808004715 Found in ATP-dependent protease La (LON); Region: LON; smart00464 357808004716 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 357808004717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808004718 Walker A motif; other site 357808004719 ATP binding site [chemical binding]; other site 357808004720 Walker B motif; other site 357808004721 arginine finger; other site 357808004722 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 357808004723 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 357808004724 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 357808004725 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 357808004726 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 357808004727 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 357808004728 Competence protein; Region: Competence; pfam03772 357808004729 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 357808004730 amidase catalytic site [active] 357808004731 Zn binding residues [ion binding]; other site 357808004732 substrate binding site [chemical binding]; other site 357808004733 PA14 domain; Region: PA14; cl08459 357808004734 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 357808004735 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 357808004736 NAD binding site [chemical binding]; other site 357808004737 substrate binding site [chemical binding]; other site 357808004738 homodimer interface [polypeptide binding]; other site 357808004739 active site 357808004740 FAD binding domain; Region: FAD_binding_4; pfam01565 357808004741 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 357808004742 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 357808004743 FAD binding domain; Region: FAD_binding_4; pfam01565 357808004744 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 357808004745 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 357808004746 Predicted permeases [General function prediction only]; Region: RarD; COG2962 357808004747 EamA-like transporter family; Region: EamA; pfam00892 357808004748 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808004749 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808004750 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357808004751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808004752 dimer interface [polypeptide binding]; other site 357808004753 phosphorylation site [posttranslational modification] 357808004754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808004755 ATP binding site [chemical binding]; other site 357808004756 Mg2+ binding site [ion binding]; other site 357808004757 G-X-G motif; other site 357808004758 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808004759 Double zinc ribbon; Region: DZR; pfam12773 357808004760 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 357808004761 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 357808004762 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 357808004763 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 357808004764 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808004765 GAF domain; Region: GAF_3; pfam13492 357808004766 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808004767 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808004768 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357808004769 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808004770 putative active site [active] 357808004771 heme pocket [chemical binding]; other site 357808004772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808004773 dimer interface [polypeptide binding]; other site 357808004774 phosphorylation site [posttranslational modification] 357808004775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808004776 ATP binding site [chemical binding]; other site 357808004777 Mg2+ binding site [ion binding]; other site 357808004778 G-X-G motif; other site 357808004779 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808004780 dimerization interface [polypeptide binding]; other site 357808004781 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808004782 GAF domain; Region: GAF; pfam01590 357808004783 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357808004784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808004785 putative active site [active] 357808004786 heme pocket [chemical binding]; other site 357808004787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808004788 dimer interface [polypeptide binding]; other site 357808004789 phosphorylation site [posttranslational modification] 357808004790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808004791 ATP binding site [chemical binding]; other site 357808004792 Mg2+ binding site [ion binding]; other site 357808004793 G-X-G motif; other site 357808004794 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 357808004795 Predicted dehydrogenase [General function prediction only]; Region: COG0579 357808004796 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 357808004797 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 357808004798 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808004799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808004800 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808004801 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 357808004802 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 357808004803 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 357808004804 Na binding site [ion binding]; other site 357808004805 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 357808004806 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808004807 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 357808004808 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 357808004809 structural tetrad; other site 357808004810 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 357808004811 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 357808004812 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 357808004813 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808004814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808004815 active site 357808004816 phosphorylation site [posttranslational modification] 357808004817 intermolecular recognition site; other site 357808004818 dimerization interface [polypeptide binding]; other site 357808004819 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808004820 DNA binding residues [nucleotide binding] 357808004821 dimerization interface [polypeptide binding]; other site 357808004822 Maf-like protein; Region: Maf; pfam02545 357808004823 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 357808004824 active site 357808004825 dimer interface [polypeptide binding]; other site 357808004826 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 357808004827 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808004828 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808004829 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 357808004830 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808004831 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808004832 phosphopeptide binding site; other site 357808004833 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808004834 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808004835 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 357808004836 cyclase homology domain; Region: CHD; cd07302 357808004837 nucleotidyl binding site; other site 357808004838 metal binding site [ion binding]; metal-binding site 357808004839 dimer interface [polypeptide binding]; other site 357808004840 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808004841 CARDB; Region: CARDB; pfam07705 357808004842 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 357808004843 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 357808004844 Walker A/P-loop; other site 357808004845 ATP binding site [chemical binding]; other site 357808004846 Q-loop/lid; other site 357808004847 ABC transporter signature motif; other site 357808004848 Walker B; other site 357808004849 D-loop; other site 357808004850 H-loop/switch region; other site 357808004851 TOBE domain; Region: TOBE_2; pfam08402 357808004852 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357808004853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808004854 dimer interface [polypeptide binding]; other site 357808004855 conserved gate region; other site 357808004856 putative PBP binding loops; other site 357808004857 ABC-ATPase subunit interface; other site 357808004858 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808004859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808004860 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808004861 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 357808004862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808004863 dimer interface [polypeptide binding]; other site 357808004864 conserved gate region; other site 357808004865 putative PBP binding loops; other site 357808004866 ABC-ATPase subunit interface; other site 357808004867 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 357808004868 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 357808004869 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 357808004870 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 357808004871 HSP70 interaction site [polypeptide binding]; other site 357808004872 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 357808004873 substrate binding site [polypeptide binding]; other site 357808004874 dimer interface [polypeptide binding]; other site 357808004875 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 357808004876 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 357808004877 DNA binding residues [nucleotide binding] 357808004878 putative dimer interface [polypeptide binding]; other site 357808004879 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 357808004880 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 357808004881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808004882 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 357808004883 Walker A motif; other site 357808004884 ATP binding site [chemical binding]; other site 357808004885 Walker B motif; other site 357808004886 arginine finger; other site 357808004887 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 357808004888 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 357808004889 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 357808004890 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 357808004891 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357808004892 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 357808004893 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 357808004894 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 357808004895 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 357808004896 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 357808004897 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 357808004898 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 357808004899 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 357808004900 Phage protein D [General function prediction only]; Region: COG3500 357808004901 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357808004902 PAAR motif; Region: PAAR_motif; pfam05488 357808004903 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 357808004904 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 357808004905 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808004906 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808004907 phosphopeptide binding site; other site 357808004908 phage tail protein domain; Region: tail_TIGR02242 357808004909 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357808004910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808004911 S-adenosylmethionine binding site [chemical binding]; other site 357808004912 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 357808004913 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 357808004914 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 357808004915 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808004916 active site 357808004917 ATP binding site [chemical binding]; other site 357808004918 substrate binding site [chemical binding]; other site 357808004919 activation loop (A-loop); other site 357808004920 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808004921 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808004922 phosphopeptide binding site; other site 357808004923 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808004924 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808004925 active site 357808004926 ATP binding site [chemical binding]; other site 357808004927 substrate binding site [chemical binding]; other site 357808004928 activation loop (A-loop); other site 357808004929 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808004930 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808004931 phosphopeptide binding site; other site 357808004932 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 357808004933 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808004934 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808004935 active site 357808004936 ATP binding site [chemical binding]; other site 357808004937 substrate binding site [chemical binding]; other site 357808004938 activation loop (A-loop); other site 357808004939 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808004940 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808004941 phosphopeptide binding site; other site 357808004942 Domain of unknown function DUF11; Region: DUF11; cl17728 357808004943 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808004944 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808004945 phosphopeptide binding site; other site 357808004946 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 357808004947 Calx-beta domain; Region: Calx-beta; cl02522 357808004948 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808004949 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808004950 phosphopeptide binding site; other site 357808004951 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 357808004952 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 357808004953 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 357808004954 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808004955 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808004956 active site 357808004957 ATP binding site [chemical binding]; other site 357808004958 substrate binding site [chemical binding]; other site 357808004959 activation loop (A-loop); other site 357808004960 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808004961 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808004962 phosphopeptide binding site; other site 357808004963 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 357808004964 E3 interaction surface; other site 357808004965 lipoyl attachment site [posttranslational modification]; other site 357808004966 e3 binding domain; Region: E3_binding; pfam02817 357808004967 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 357808004968 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 357808004969 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 357808004970 CRISPR/Cas system-associated protein Csa8a2; Region: Cas8a2_I-A; cl09907 357808004971 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 357808004972 putative active site [active] 357808004973 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 357808004974 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 357808004975 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 357808004976 putative active site [active] 357808004977 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 357808004978 amidase catalytic site [active] 357808004979 substrate binding site [chemical binding]; other site 357808004980 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 357808004981 UV-endonuclease UvdE; Region: UvdE; cl10036 357808004982 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 357808004983 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 357808004984 active site 357808004985 HIGH motif; other site 357808004986 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 357808004987 active site 357808004988 KMSKS motif; other site 357808004989 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808004990 phosphopeptide binding site; other site 357808004991 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 357808004992 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 357808004993 FOG: CBS domain [General function prediction only]; Region: COG0517 357808004994 FOG: CBS domain [General function prediction only]; Region: COG0517 357808004995 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 357808004996 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 357808004997 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 357808004998 substrate binding pocket [chemical binding]; other site 357808004999 chain length determination region; other site 357808005000 substrate-Mg2+ binding site; other site 357808005001 catalytic residues [active] 357808005002 aspartate-rich region 1; other site 357808005003 active site lid residues [active] 357808005004 aspartate-rich region 2; other site 357808005005 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357808005006 catalytic core [active] 357808005007 HAS barrel domain; Region: HAS-barrel; pfam09378 357808005008 HerA helicase [Replication, recombination, and repair]; Region: COG0433 357808005009 Domain of unknown function DUF87; Region: DUF87; pfam01935 357808005010 large tegument protein UL36; Provisional; Region: PHA03247 357808005011 cyanophycin synthetase; Provisional; Region: PRK14016 357808005012 cyanophycin synthetase; Provisional; Region: PRK14016 357808005013 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 357808005014 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 357808005015 metal binding site [ion binding]; metal-binding site 357808005016 dimer interface [polypeptide binding]; other site 357808005017 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 357808005018 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 357808005019 active site 357808005020 dimer interfaces [polypeptide binding]; other site 357808005021 catalytic residues [active] 357808005022 Predicted permeases [General function prediction only]; Region: COG0701 357808005023 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 357808005024 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357808005025 dimerization interface [polypeptide binding]; other site 357808005026 putative DNA binding site [nucleotide binding]; other site 357808005027 putative Zn2+ binding site [ion binding]; other site 357808005028 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808005029 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 357808005030 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 357808005031 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 357808005032 active site 357808005033 homodimer interface [polypeptide binding]; other site 357808005034 catalytic site [active] 357808005035 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808005036 putative active site [active] 357808005037 Transcriptional regulator [Transcription]; Region: LytR; COG1316 357808005038 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 357808005039 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 357808005040 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 357808005041 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 357808005042 active site 357808005043 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 357808005044 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 357808005045 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 357808005046 putative active site [active] 357808005047 metal binding site [ion binding]; metal-binding site 357808005048 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808005049 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808005050 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 357808005051 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357808005052 active site 357808005053 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 357808005054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 357808005055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 357808005056 NAD(P) binding site [chemical binding]; other site 357808005057 hypothetical protein; Provisional; Region: PRK14678 357808005058 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 357808005059 putative trimer interface [polypeptide binding]; other site 357808005060 putative active site [active] 357808005061 putative substrate binding site [chemical binding]; other site 357808005062 putative CoA binding site [chemical binding]; other site 357808005063 FOG: CBS domain [General function prediction only]; Region: COG0517 357808005064 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 357808005065 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 357808005066 E3 interaction surface; other site 357808005067 lipoyl attachment site [posttranslational modification]; other site 357808005068 e3 binding domain; Region: E3_binding; pfam02817 357808005069 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 357808005070 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 357808005071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 357808005072 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 357808005073 alpha subunit interface [polypeptide binding]; other site 357808005074 TPP binding site [chemical binding]; other site 357808005075 heterodimer interface [polypeptide binding]; other site 357808005076 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 357808005077 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 357808005078 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 357808005079 tetramer interface [polypeptide binding]; other site 357808005080 TPP-binding site [chemical binding]; other site 357808005081 heterodimer interface [polypeptide binding]; other site 357808005082 phosphorylation loop region [posttranslational modification] 357808005083 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 357808005084 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 357808005085 RNA binding site [nucleotide binding]; other site 357808005086 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 357808005087 RNA binding site [nucleotide binding]; other site 357808005088 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 357808005089 RNA binding site [nucleotide binding]; other site 357808005090 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 357808005091 RNA binding site [nucleotide binding]; other site 357808005092 Clp protease ATP binding subunit; Region: clpC; CHL00095 357808005093 Clp amino terminal domain; Region: Clp_N; pfam02861 357808005094 Clp amino terminal domain; Region: Clp_N; pfam02861 357808005095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808005096 Walker A motif; other site 357808005097 ATP binding site [chemical binding]; other site 357808005098 Walker B motif; other site 357808005099 arginine finger; other site 357808005100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808005101 Walker A motif; other site 357808005102 ATP binding site [chemical binding]; other site 357808005103 Walker B motif; other site 357808005104 arginine finger; other site 357808005105 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 357808005106 DNA repair protein RadA; Provisional; Region: PRK11823 357808005107 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 357808005108 Walker A motif/ATP binding site; other site 357808005109 ATP binding site [chemical binding]; other site 357808005110 Walker B motif; other site 357808005111 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 357808005112 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 357808005113 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 357808005114 putative active site [active] 357808005115 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 357808005116 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 357808005117 active site 357808005118 DNA repair protein RecN; Region: recN; TIGR00634 357808005119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808005120 Walker A/P-loop; other site 357808005121 ATP binding site [chemical binding]; other site 357808005122 Divergent AAA domain; Region: AAA_4; pfam04326 357808005123 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 357808005124 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 357808005125 HEAT repeats; Region: HEAT_2; pfam13646 357808005126 HEAT repeats; Region: HEAT_2; pfam13646 357808005127 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808005128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808005129 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808005130 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 357808005131 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357808005132 inhibitor-cofactor binding pocket; inhibition site 357808005133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808005134 catalytic residue [active] 357808005135 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 357808005136 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 357808005137 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 357808005138 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 357808005139 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 357808005140 metal binding site [ion binding]; metal-binding site 357808005141 dimer interface [polypeptide binding]; other site 357808005142 intracellular protease, PfpI family; Region: PfpI; TIGR01382 357808005143 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 357808005144 conserved cys residue [active] 357808005145 Right handed beta helix region; Region: Beta_helix; pfam13229 357808005146 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 357808005147 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357808005148 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357808005149 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 357808005150 DNA binding residues [nucleotide binding] 357808005151 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 357808005152 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 357808005153 tRNA; other site 357808005154 putative tRNA binding site [nucleotide binding]; other site 357808005155 putative NADP binding site [chemical binding]; other site 357808005156 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 357808005157 Chlorite dismutase; Region: Chlor_dismutase; cl01280 357808005158 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 357808005159 substrate binding site [chemical binding]; other site 357808005160 active site 357808005161 Ferrochelatase; Region: Ferrochelatase; pfam00762 357808005162 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 357808005163 C-terminal domain interface [polypeptide binding]; other site 357808005164 active site 357808005165 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 357808005166 active site 357808005167 N-terminal domain interface [polypeptide binding]; other site 357808005168 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 357808005169 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 357808005170 domain interfaces; other site 357808005171 active site 357808005172 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 357808005173 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 357808005174 active site 357808005175 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 357808005176 dimer interface [polypeptide binding]; other site 357808005177 active site 357808005178 Schiff base residues; other site 357808005179 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 357808005180 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357808005181 inhibitor-cofactor binding pocket; inhibition site 357808005182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808005183 catalytic residue [active] 357808005184 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357808005185 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357808005186 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 357808005187 Probable zinc-binding domain; Region: zf-trcl; pfam13451 357808005188 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 357808005189 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 357808005190 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 357808005191 homodimer interface [polypeptide binding]; other site 357808005192 substrate-cofactor binding pocket; other site 357808005193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808005194 catalytic residue [active] 357808005195 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 357808005196 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 357808005197 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 357808005198 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808005199 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808005200 DNA binding residues [nucleotide binding] 357808005201 Putative zinc-finger; Region: zf-HC2; pfam13490 357808005202 Anti-sigma-K factor rskA; Region: RskA; pfam10099 357808005203 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 357808005204 Leucine carboxyl methyltransferase; Region: LCM; cl01306 357808005205 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357808005206 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357808005207 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 357808005208 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 357808005209 amphipathic channel; other site 357808005210 Asn-Pro-Ala signature motifs; other site 357808005211 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 357808005212 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 357808005213 DAK2 domain; Region: Dak2; cl03685 357808005214 glycerol kinase; Provisional; Region: glpK; PRK00047 357808005215 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 357808005216 N- and C-terminal domain interface [polypeptide binding]; other site 357808005217 active site 357808005218 MgATP binding site [chemical binding]; other site 357808005219 catalytic site [active] 357808005220 metal binding site [ion binding]; metal-binding site 357808005221 putative homotetramer interface [polypeptide binding]; other site 357808005222 glycerol binding site [chemical binding]; other site 357808005223 homodimer interface [polypeptide binding]; other site 357808005224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357808005225 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 357808005226 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 357808005227 active site 357808005228 active pocket/dimerization site; other site 357808005229 phosphorylation site [posttranslational modification] 357808005230 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 357808005231 dimerization domain swap beta strand [polypeptide binding]; other site 357808005232 regulatory protein interface [polypeptide binding]; other site 357808005233 active site 357808005234 regulatory phosphorylation site [posttranslational modification]; other site 357808005235 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 357808005236 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 357808005237 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 357808005238 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 357808005239 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 357808005240 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 357808005241 dimer interface [polypeptide binding]; other site 357808005242 ssDNA binding site [nucleotide binding]; other site 357808005243 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357808005244 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 357808005245 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 357808005246 putative substrate binding pocket [chemical binding]; other site 357808005247 AC domain interface; other site 357808005248 catalytic triad [active] 357808005249 AB domain interface; other site 357808005250 interchain disulfide; other site 357808005251 prolyl-tRNA synthetase; Provisional; Region: PRK08661 357808005252 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 357808005253 dimer interface [polypeptide binding]; other site 357808005254 motif 1; other site 357808005255 active site 357808005256 motif 2; other site 357808005257 motif 3; other site 357808005258 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 357808005259 anticodon binding site; other site 357808005260 zinc-binding site [ion binding]; other site 357808005261 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 357808005262 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 357808005263 substrate binding site [chemical binding]; other site 357808005264 hexamer interface [polypeptide binding]; other site 357808005265 metal binding site [ion binding]; metal-binding site 357808005266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808005267 putative substrate translocation pore; other site 357808005268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808005269 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357808005270 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808005271 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808005272 phosphopeptide binding site; other site 357808005273 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 357808005274 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808005275 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808005276 phosphopeptide binding site; other site 357808005277 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 357808005278 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357808005279 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357808005280 Transposase [DNA replication, recombination, and repair]; Region: COG5421 357808005281 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 357808005282 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 357808005283 putative active site [active] 357808005284 putative FMN binding site [chemical binding]; other site 357808005285 putative substrate binding site [chemical binding]; other site 357808005286 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 357808005287 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357808005288 nucleophilic elbow; other site 357808005289 catalytic triad; other site 357808005290 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357808005291 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357808005292 ligand binding site [chemical binding]; other site 357808005293 flexible hinge region; other site 357808005294 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 357808005295 YcfA-like protein; Region: YcfA; pfam07927 357808005296 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 357808005297 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 357808005298 active site 357808005299 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 357808005300 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 357808005301 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357808005302 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 357808005303 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 357808005304 putative dimerization interface [polypeptide binding]; other site 357808005305 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 357808005306 4Fe-4S binding domain; Region: Fer4; pfam00037 357808005307 This CD includes the respiratory arsenate reductase, As(V), catalytic subunit (ArrA) and other related proteins. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_Arsenate-R; cd02757 357808005308 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 357808005309 putative [Fe4-S4] binding site [ion binding]; other site 357808005310 putative molybdopterin cofactor binding site [chemical binding]; other site 357808005311 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357808005312 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 357808005313 putative molybdopterin cofactor binding site; other site 357808005314 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 357808005315 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 357808005316 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 357808005317 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 357808005318 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 357808005319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808005320 Walker A/P-loop; other site 357808005321 ATP binding site [chemical binding]; other site 357808005322 Q-loop/lid; other site 357808005323 ABC transporter signature motif; other site 357808005324 Walker B; other site 357808005325 D-loop; other site 357808005326 H-loop/switch region; other site 357808005327 TOBE domain; Region: TOBE_2; pfam08402 357808005328 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 357808005329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808005330 dimer interface [polypeptide binding]; other site 357808005331 conserved gate region; other site 357808005332 putative PBP binding loops; other site 357808005333 ABC-ATPase subunit interface; other site 357808005334 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 357808005335 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357808005336 Uncharacterized conserved protein [Function unknown]; Region: COG2006 357808005337 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 357808005338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808005339 dimer interface [polypeptide binding]; other site 357808005340 conserved gate region; other site 357808005341 putative PBP binding loops; other site 357808005342 ABC-ATPase subunit interface; other site 357808005343 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 357808005344 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 357808005345 Walker A/P-loop; other site 357808005346 ATP binding site [chemical binding]; other site 357808005347 Q-loop/lid; other site 357808005348 ABC transporter signature motif; other site 357808005349 Walker B; other site 357808005350 D-loop; other site 357808005351 H-loop/switch region; other site 357808005352 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 357808005353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808005354 dimer interface [polypeptide binding]; other site 357808005355 conserved gate region; other site 357808005356 putative PBP binding loops; other site 357808005357 ABC-ATPase subunit interface; other site 357808005358 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 357808005359 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357808005360 substrate binding pocket [chemical binding]; other site 357808005361 membrane-bound complex binding site; other site 357808005362 hinge residues; other site 357808005363 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 357808005364 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 357808005365 Homeodomain-like domain; Region: HTH_23; pfam13384 357808005366 Winged helix-turn helix; Region: HTH_29; pfam13551 357808005367 Winged helix-turn helix; Region: HTH_33; pfam13592 357808005368 DDE superfamily endonuclease; Region: DDE_3; pfam13358 357808005369 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 357808005370 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 357808005371 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 357808005372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808005373 NAD(P) binding site [chemical binding]; other site 357808005374 active site 357808005375 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357808005376 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 357808005377 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357808005378 phytoene desaturase; Region: crtI_fam; TIGR02734 357808005379 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357808005380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808005381 dimer interface [polypeptide binding]; other site 357808005382 conserved gate region; other site 357808005383 putative PBP binding loops; other site 357808005384 ABC-ATPase subunit interface; other site 357808005385 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 357808005386 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 357808005387 Walker A/P-loop; other site 357808005388 ATP binding site [chemical binding]; other site 357808005389 Q-loop/lid; other site 357808005390 ABC transporter signature motif; other site 357808005391 Walker B; other site 357808005392 D-loop; other site 357808005393 H-loop/switch region; other site 357808005394 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 357808005395 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 357808005396 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 357808005397 dimer interface [polypeptide binding]; other site 357808005398 conserved gate region; other site 357808005399 ABC-ATPase subunit interface; other site 357808005400 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 357808005401 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 357808005402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 357808005403 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 357808005404 tandem repeat interface [polypeptide binding]; other site 357808005405 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 357808005406 oligomer interface [polypeptide binding]; other site 357808005407 active site residues [active] 357808005408 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 357808005409 tandem repeat interface [polypeptide binding]; other site 357808005410 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 357808005411 oligomer interface [polypeptide binding]; other site 357808005412 active site residues [active] 357808005413 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 357808005414 ATP-grasp domain; Region: ATP-grasp; pfam02222 357808005415 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 357808005416 Peptidase C26; Region: Peptidase_C26; pfam07722 357808005417 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 357808005418 catalytic triad [active] 357808005419 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808005420 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808005421 phosphopeptide binding site; other site 357808005422 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357808005423 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357808005424 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 357808005425 DNA methylase; Region: N6_N4_Mtase; pfam01555 357808005426 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 357808005427 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 357808005428 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 357808005429 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 357808005430 active site 357808005431 ADP/pyrophosphate binding site [chemical binding]; other site 357808005432 dimerization interface [polypeptide binding]; other site 357808005433 allosteric effector site; other site 357808005434 fructose-1,6-bisphosphate binding site; other site 357808005435 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 357808005436 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 357808005437 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 357808005438 active site 357808005439 ADP/pyrophosphate binding site [chemical binding]; other site 357808005440 dimerization interface [polypeptide binding]; other site 357808005441 allosteric effector site; other site 357808005442 fructose-1,6-bisphosphate binding site; other site 357808005443 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 357808005444 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 357808005445 MoxR-like ATPases [General function prediction only]; Region: COG0714 357808005446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808005447 Walker A motif; other site 357808005448 ATP binding site [chemical binding]; other site 357808005449 Walker B motif; other site 357808005450 arginine finger; other site 357808005451 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 357808005452 Protein of unknown function DUF58; Region: DUF58; pfam01882 357808005453 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 357808005454 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808005455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808005456 S-adenosylmethionine binding site [chemical binding]; other site 357808005457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357808005458 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 357808005459 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 357808005460 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 357808005461 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 357808005462 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 357808005463 metal ion-dependent adhesion site (MIDAS); other site 357808005464 Protein kinase domain; Region: Pkinase; pfam00069 357808005465 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808005466 active site 357808005467 ATP binding site [chemical binding]; other site 357808005468 substrate binding site [chemical binding]; other site 357808005469 activation loop (A-loop); other site 357808005470 Double zinc ribbon; Region: DZR; pfam12773 357808005471 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808005472 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808005473 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808005474 phosphopeptide binding site; other site 357808005475 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 357808005476 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 357808005477 putative active site [active] 357808005478 catalytic triad [active] 357808005479 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357808005480 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 357808005481 substrate binding pocket [chemical binding]; other site 357808005482 membrane-bound complex binding site; other site 357808005483 hinge residues; other site 357808005484 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 357808005485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808005486 Walker A motif; other site 357808005487 ATP binding site [chemical binding]; other site 357808005488 Walker B motif; other site 357808005489 Peptidase family M41; Region: Peptidase_M41; pfam01434 357808005490 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 357808005491 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 357808005492 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 357808005493 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 357808005494 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 357808005495 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 357808005496 active site 357808005497 Substrate binding site; other site 357808005498 Mg++ binding site; other site 357808005499 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 357808005500 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 357808005501 putative trimer interface [polypeptide binding]; other site 357808005502 putative CoA binding site [chemical binding]; other site 357808005503 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357808005504 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 357808005505 NADP-binding site; other site 357808005506 homotetramer interface [polypeptide binding]; other site 357808005507 substrate binding site [chemical binding]; other site 357808005508 homodimer interface [polypeptide binding]; other site 357808005509 active site 357808005510 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 357808005511 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 357808005512 Ferritin-like domain; Region: Ferritin; pfam00210 357808005513 ferroxidase diiron center [ion binding]; other site 357808005514 CRISPR-associated protein; Region: TIGR03986 357808005515 CRISPR-associated protein; Region: TIGR03986 357808005516 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 357808005517 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 357808005518 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 357808005519 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 357808005520 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 357808005521 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 357808005522 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 357808005523 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741 357808005524 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808005525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808005526 DNA binding residues [nucleotide binding] 357808005527 AAA-like domain; Region: AAA_10; pfam12846 357808005528 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cl09837 357808005529 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 357808005530 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 357808005531 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 357808005532 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 357808005533 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 357808005534 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 357808005535 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 357808005536 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 357808005537 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 357808005538 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 357808005539 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 357808005540 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808005541 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808005542 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 357808005543 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 357808005544 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357808005545 active site 357808005546 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 357808005547 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 357808005548 ATP binding site [chemical binding]; other site 357808005549 Walker A motif; other site 357808005550 hexamer interface [polypeptide binding]; other site 357808005551 Walker B motif; other site 357808005552 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 357808005553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808005554 Walker A motif; other site 357808005555 ATP binding site [chemical binding]; other site 357808005556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808005557 TPR repeat; Region: TPR_11; pfam13414 357808005558 binding surface 357808005559 TPR motif; other site 357808005560 CAAX protease self-immunity; Region: Abi; pfam02517 357808005561 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14338 357808005562 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 357808005563 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808005564 FeS/SAM binding site; other site 357808005565 TRAM domain; Region: TRAM; pfam01938 357808005566 Methyltransferase domain; Region: Methyltransf_26; pfam13659 357808005567 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 357808005568 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 357808005569 putative active site [active] 357808005570 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808005571 MoxR-like ATPases [General function prediction only]; Region: COG0714 357808005572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808005573 Walker A motif; other site 357808005574 ATP binding site [chemical binding]; other site 357808005575 Walker B motif; other site 357808005576 arginine finger; other site 357808005577 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 357808005578 Protein of unknown function DUF58; Region: DUF58; pfam01882 357808005579 Aerotolerance regulator N-terminal; Region: BatA; cl06567 357808005580 von Willebrand factor type A domain; Region: VWA_2; pfam13519 357808005581 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 357808005582 metal ion-dependent adhesion site (MIDAS); other site 357808005583 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 357808005584 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 357808005585 metal ion-dependent adhesion site (MIDAS); other site 357808005586 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 357808005587 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 357808005588 Phosphotransferase enzyme family; Region: APH; pfam01636 357808005589 active site 357808005590 substrate binding site [chemical binding]; other site 357808005591 ATP binding site [chemical binding]; other site 357808005592 Flavodoxin domain; Region: Flavodoxin_5; cl17428 357808005593 FOG: CBS domain [General function prediction only]; Region: COG0517 357808005594 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 357808005595 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808005596 GAF domain; Region: GAF_3; pfam13492 357808005597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808005598 dimer interface [polypeptide binding]; other site 357808005599 phosphorylation site [posttranslational modification] 357808005600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808005601 ATP binding site [chemical binding]; other site 357808005602 Mg2+ binding site [ion binding]; other site 357808005603 G-X-G motif; other site 357808005604 Helix-turn-helix domain; Region: HTH_38; pfam13936 357808005605 Winged helix-turn helix; Region: HTH_29; pfam13551 357808005606 DNA-binding interface [nucleotide binding]; DNA binding site 357808005607 Integrase core domain; Region: rve; pfam00665 357808005608 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 357808005609 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 357808005610 active site 357808005611 catalytic site [active] 357808005612 substrate binding site [chemical binding]; other site 357808005613 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 357808005614 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 357808005615 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 357808005616 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 357808005617 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 357808005618 PUCC protein; Region: PUCC; pfam03209 357808005619 magnesium chelatase subunit H; Provisional; Region: PRK12493 357808005620 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 357808005621 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 357808005622 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 357808005623 diiron binding motif [ion binding]; other site 357808005624 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 357808005625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808005626 S-adenosylmethionine binding site [chemical binding]; other site 357808005627 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 357808005628 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 357808005629 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357808005630 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 357808005631 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 357808005632 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 357808005633 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 357808005634 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 357808005635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808005636 S-adenosylmethionine binding site [chemical binding]; other site 357808005637 PUCC protein; Region: PUCC; pfam03209 357808005638 hydrolase, alpha/beta fold family protein; Region: PLN02824 357808005639 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 357808005640 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 357808005641 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 357808005642 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 357808005643 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 357808005644 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 357808005645 Sulfate transporter family; Region: Sulfate_transp; pfam00916 357808005646 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 357808005647 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 357808005648 arsenical-resistance protein; Region: acr3; TIGR00832 357808005649 CAAX protease self-immunity; Region: Abi; pfam02517 357808005650 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 357808005651 dimer interface [polypeptide binding]; other site 357808005652 substrate binding site [chemical binding]; other site 357808005653 ATP binding site [chemical binding]; other site 357808005654 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 357808005655 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357808005656 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 357808005657 ABC transporter signature motif; other site 357808005658 Walker B; other site 357808005659 D-loop; other site 357808005660 H-loop/switch region; other site 357808005661 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357808005662 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 357808005663 Walker A/P-loop; other site 357808005664 ATP binding site [chemical binding]; other site 357808005665 Q-loop/lid; other site 357808005666 ABC transporter signature motif; other site 357808005667 Walker B; other site 357808005668 D-loop; other site 357808005669 H-loop/switch region; other site 357808005670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808005671 Walker A/P-loop; other site 357808005672 ATP binding site [chemical binding]; other site 357808005673 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 357808005674 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 357808005675 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 357808005676 substrate binding site [chemical binding]; other site 357808005677 multimerization interface [polypeptide binding]; other site 357808005678 ATP binding site [chemical binding]; other site 357808005679 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 357808005680 thiamine phosphate binding site [chemical binding]; other site 357808005681 active site 357808005682 pyrophosphate binding site [ion binding]; other site 357808005683 Peptidase family M48; Region: Peptidase_M48; cl12018 357808005684 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 357808005685 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 357808005686 putative dimer interface [polypeptide binding]; other site 357808005687 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 357808005688 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 357808005689 active site 357808005690 NTP binding site [chemical binding]; other site 357808005691 metal binding triad [ion binding]; metal-binding site 357808005692 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 357808005693 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357808005694 Zn2+ binding site [ion binding]; other site 357808005695 Mg2+ binding site [ion binding]; other site 357808005696 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 357808005697 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 357808005698 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 357808005699 active site 357808005700 catalytic site [active] 357808005701 Nuclease-related domain; Region: NERD; pfam08378 357808005702 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 357808005703 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 357808005704 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808005705 dimerization interface [polypeptide binding]; other site 357808005706 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808005707 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808005708 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357808005709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808005710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357808005711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357808005712 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 357808005713 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 357808005714 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 357808005715 DNA binding site [nucleotide binding] 357808005716 catalytic residue [active] 357808005717 H2TH interface [polypeptide binding]; other site 357808005718 putative catalytic residues [active] 357808005719 turnover-facilitating residue; other site 357808005720 intercalation triad [nucleotide binding]; other site 357808005721 8OG recognition residue [nucleotide binding]; other site 357808005722 putative reading head residues; other site 357808005723 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 357808005724 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 357808005725 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 357808005726 Transglycosylase; Region: Transgly; pfam00912 357808005727 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 357808005728 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 357808005729 GAF domain; Region: GAF_2; pfam13185 357808005730 GAF domain; Region: GAF; pfam01590 357808005731 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808005732 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808005733 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808005734 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808005735 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357808005736 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357808005737 metal binding site [ion binding]; metal-binding site 357808005738 active site 357808005739 I-site; other site 357808005740 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 357808005741 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 357808005742 active site 357808005743 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 357808005744 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 357808005745 Tetramer interface [polypeptide binding]; other site 357808005746 active site 357808005747 FMN-binding site [chemical binding]; other site 357808005748 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 357808005749 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 357808005750 acyl-activating enzyme (AAE) consensus motif; other site 357808005751 putative AMP binding site [chemical binding]; other site 357808005752 putative active site [active] 357808005753 putative CoA binding site [chemical binding]; other site 357808005754 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 357808005755 AAA domain; Region: AAA_17; pfam13207 357808005756 Response regulator receiver domain; Region: Response_reg; pfam00072 357808005757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808005758 active site 357808005759 phosphorylation site [posttranslational modification] 357808005760 intermolecular recognition site; other site 357808005761 dimerization interface [polypeptide binding]; other site 357808005762 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357808005763 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 357808005764 tartrate dehydrogenase; Region: TTC; TIGR02089 357808005765 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 357808005766 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 357808005767 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 357808005768 substrate binding site [chemical binding]; other site 357808005769 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 357808005770 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 357808005771 substrate binding site [chemical binding]; other site 357808005772 ligand binding site [chemical binding]; other site 357808005773 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 357808005774 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 357808005775 homodimer interface [polypeptide binding]; other site 357808005776 substrate-cofactor binding pocket; other site 357808005777 catalytic residue [active] 357808005778 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 357808005779 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 357808005780 active site 357808005781 catalytic residues [active] 357808005782 metal binding site [ion binding]; metal-binding site 357808005783 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 357808005784 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 357808005785 Prephenate dehydratase; Region: PDT; pfam00800 357808005786 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 357808005787 putative L-Phe binding site [chemical binding]; other site 357808005788 2-isopropylmalate synthase; Validated; Region: PRK00915 357808005789 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 357808005790 active site 357808005791 catalytic residues [active] 357808005792 metal binding site [ion binding]; metal-binding site 357808005793 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 357808005794 ketol-acid reductoisomerase; Provisional; Region: PRK05479 357808005795 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 357808005796 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 357808005797 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 357808005798 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 357808005799 putative valine binding site [chemical binding]; other site 357808005800 dimer interface [polypeptide binding]; other site 357808005801 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 357808005802 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 357808005803 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357808005804 PYR/PP interface [polypeptide binding]; other site 357808005805 dimer interface [polypeptide binding]; other site 357808005806 TPP binding site [chemical binding]; other site 357808005807 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357808005808 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 357808005809 TPP-binding site [chemical binding]; other site 357808005810 dimer interface [polypeptide binding]; other site 357808005811 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 357808005812 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 357808005813 tetramer interface [polypeptide binding]; other site 357808005814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808005815 catalytic residue [active] 357808005816 homoserine dehydrogenase; Provisional; Region: PRK06270 357808005817 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 357808005818 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 357808005819 active site 357808005820 diiron metal binding site [ion binding]; other site 357808005821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357808005822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357808005823 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357808005824 dimerization interface [polypeptide binding]; other site 357808005825 calcium/proton exchanger (cax); Region: cax; TIGR00378 357808005826 calcium/proton exchanger (cax); Region: cax; TIGR00378 357808005827 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 357808005828 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 357808005829 dimerization interface [polypeptide binding]; other site 357808005830 putative active cleft [active] 357808005831 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 357808005832 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 357808005833 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 357808005834 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 357808005835 dimer interface [polypeptide binding]; other site 357808005836 anticodon binding site; other site 357808005837 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 357808005838 homodimer interface [polypeptide binding]; other site 357808005839 motif 1; other site 357808005840 active site 357808005841 motif 2; other site 357808005842 GAD domain; Region: GAD; pfam02938 357808005843 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 357808005844 active site 357808005845 motif 3; other site 357808005846 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 357808005847 Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091 357808005848 Peptidase family M48; Region: Peptidase_M48; cl12018 357808005849 GAF domain; Region: GAF_3; pfam13492 357808005850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357808005851 Histidine kinase; Region: HisKA_3; pfam07730 357808005852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808005853 ATP binding site [chemical binding]; other site 357808005854 Mg2+ binding site [ion binding]; other site 357808005855 G-X-G motif; other site 357808005856 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808005857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808005858 active site 357808005859 phosphorylation site [posttranslational modification] 357808005860 intermolecular recognition site; other site 357808005861 dimerization interface [polypeptide binding]; other site 357808005862 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808005863 DNA binding residues [nucleotide binding] 357808005864 dimerization interface [polypeptide binding]; other site 357808005865 Domain of unknown function (DUF897); Region: DUF897; pfam05982 357808005866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808005867 S-adenosylmethionine binding site [chemical binding]; other site 357808005868 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 357808005869 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 357808005870 Queuine tRNA-ribosyltransferase; Region: TGT; pfam01702 357808005871 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 357808005872 dimer interface [polypeptide binding]; other site 357808005873 active site 357808005874 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 357808005875 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 357808005876 putative MPT binding site; other site 357808005877 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 357808005878 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 357808005879 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 357808005880 putative active site [active] 357808005881 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 357808005882 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 357808005883 MOFRL family; Region: MOFRL; pfam05161 357808005884 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 357808005885 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 357808005886 active site 357808005887 Zn binding site [ion binding]; other site 357808005888 TPR repeat; Region: TPR_11; pfam13414 357808005889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808005890 TPR motif; other site 357808005891 binding surface 357808005892 TPR repeat; Region: TPR_11; pfam13414 357808005893 ribonuclease PH; Reviewed; Region: rph; PRK00173 357808005894 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 357808005895 oligomer interface [polypeptide binding]; other site 357808005896 RNA binding site [nucleotide binding]; other site 357808005897 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 357808005898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808005899 Coenzyme A binding pocket [chemical binding]; other site 357808005900 acetyl-CoA synthetase; Provisional; Region: PRK00174 357808005901 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 357808005902 active site 357808005903 CoA binding site [chemical binding]; other site 357808005904 acyl-activating enzyme (AAE) consensus motif; other site 357808005905 AMP binding site [chemical binding]; other site 357808005906 acetate binding site [chemical binding]; other site 357808005907 acetyl-CoA synthetase; Provisional; Region: PRK00174 357808005908 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 357808005909 active site 357808005910 CoA binding site [chemical binding]; other site 357808005911 acyl-activating enzyme (AAE) consensus motif; other site 357808005912 AMP binding site [chemical binding]; other site 357808005913 acetate binding site [chemical binding]; other site 357808005914 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 357808005915 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 357808005916 active site 357808005917 catalytic site [active] 357808005918 substrate binding site [chemical binding]; other site 357808005919 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 357808005920 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357808005921 ligand binding site [chemical binding]; other site 357808005922 flexible hinge region; other site 357808005923 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 357808005924 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 357808005925 metal binding triad; other site 357808005926 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 357808005927 DHH family; Region: DHH; pfam01368 357808005928 DHHA1 domain; Region: DHHA1; pfam02272 357808005929 TPR repeat; Region: TPR_11; pfam13414 357808005930 Tetratricopeptide repeat; Region: TPR_1; pfam00515 357808005931 CHAT domain; Region: CHAT; cl17868 357808005932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 357808005933 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 357808005934 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 357808005935 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 357808005936 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 357808005937 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 357808005938 catalytic residue [active] 357808005939 putative FPP diphosphate binding site; other site 357808005940 putative FPP binding hydrophobic cleft; other site 357808005941 dimer interface [polypeptide binding]; other site 357808005942 putative IPP diphosphate binding site; other site 357808005943 ribosome recycling factor; Reviewed; Region: frr; PRK00083 357808005944 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 357808005945 hinge region; other site 357808005946 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 357808005947 putative nucleotide binding site [chemical binding]; other site 357808005948 uridine monophosphate binding site [chemical binding]; other site 357808005949 homohexameric interface [polypeptide binding]; other site 357808005950 elongation factor Ts; Reviewed; Region: tsf; PRK12332 357808005951 UBA/TS-N domain; Region: UBA; pfam00627 357808005952 Elongation factor TS; Region: EF_TS; pfam00889 357808005953 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 357808005954 rRNA interaction site [nucleotide binding]; other site 357808005955 S8 interaction site; other site 357808005956 putative laminin-1 binding site; other site 357808005957 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 357808005958 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 357808005959 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 357808005960 prephenate dehydrogenase; Validated; Region: PRK08507 357808005961 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 357808005962 B12 binding site [chemical binding]; other site 357808005963 cobalt ligand [ion binding]; other site 357808005964 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 357808005965 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 357808005966 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 357808005967 Walker A; other site 357808005968 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 357808005969 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357808005970 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357808005971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808005972 homodimer interface [polypeptide binding]; other site 357808005973 catalytic residue [active] 357808005974 GAF domain; Region: GAF_2; pfam13185 357808005975 GAF domain; Region: GAF; pfam01590 357808005976 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 357808005977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808005978 putative active site [active] 357808005979 heme pocket [chemical binding]; other site 357808005980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808005981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808005982 putative active site [active] 357808005983 heme pocket [chemical binding]; other site 357808005984 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808005985 phosphorylation site [posttranslational modification] 357808005986 dimer interface [polypeptide binding]; other site 357808005987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808005988 ATP binding site [chemical binding]; other site 357808005989 Mg2+ binding site [ion binding]; other site 357808005990 G-X-G motif; other site 357808005991 Response regulator receiver domain; Region: Response_reg; pfam00072 357808005992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808005993 active site 357808005994 phosphorylation site [posttranslational modification] 357808005995 intermolecular recognition site; other site 357808005996 dimerization interface [polypeptide binding]; other site 357808005997 Predicted methyltransferases [General function prediction only]; Region: COG0313 357808005998 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 357808005999 putative SAM binding site [chemical binding]; other site 357808006000 putative homodimer interface [polypeptide binding]; other site 357808006001 aspartate kinase; Provisional; Region: PRK06291 357808006002 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 357808006003 nucleotide binding site [chemical binding]; other site 357808006004 substrate binding site [chemical binding]; other site 357808006005 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 357808006006 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 357808006007 FAD binding site [chemical binding]; other site 357808006008 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357808006009 Ligand Binding Site [chemical binding]; other site 357808006010 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357808006011 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 357808006012 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 357808006013 active site 357808006014 HIGH motif; other site 357808006015 KMSKS motif; other site 357808006016 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 357808006017 tRNA binding surface [nucleotide binding]; other site 357808006018 anticodon binding site; other site 357808006019 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 357808006020 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 357808006021 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 357808006022 active site 357808006023 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 357808006024 Ligand Binding Site [chemical binding]; other site 357808006025 Molecular Tunnel; other site 357808006026 hypothetical protein; Validated; Region: PRK08245 357808006027 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357808006028 Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950 357808006029 Predicted amidohydrolase [General function prediction only]; Region: COG0388 357808006030 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 357808006031 active site 357808006032 catalytic triad [active] 357808006033 dimer interface [polypeptide binding]; other site 357808006034 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 357808006035 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 357808006036 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357808006037 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 357808006038 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 357808006039 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 357808006040 HAMP domain; Region: HAMP; pfam00672 357808006041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808006042 dimer interface [polypeptide binding]; other site 357808006043 phosphorylation site [posttranslational modification] 357808006044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808006045 ATP binding site [chemical binding]; other site 357808006046 Mg2+ binding site [ion binding]; other site 357808006047 G-X-G motif; other site 357808006048 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 357808006049 transmembrane helices; other site 357808006050 TrkA-C domain; Region: TrkA_C; pfam02080 357808006051 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 357808006052 TrkA-C domain; Region: TrkA_C; pfam02080 357808006053 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 357808006054 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 357808006055 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 357808006056 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 357808006057 putative active site [active] 357808006058 putative metal binding site [ion binding]; other site 357808006059 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 357808006060 ParB-like nuclease domain; Region: ParBc; cl02129 357808006061 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 357808006062 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 357808006063 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357808006064 P-loop; other site 357808006065 Magnesium ion binding site [ion binding]; other site 357808006066 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 357808006067 L-lactate permease; Region: Lactate_perm; cl00701 357808006068 Uncharacterized conserved protein [Function unknown]; Region: COG2442 357808006069 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 357808006070 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 357808006071 active site 357808006072 HIGH motif; other site 357808006073 dimer interface [polypeptide binding]; other site 357808006074 KMSKS motif; other site 357808006075 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357808006076 RNA binding surface [nucleotide binding]; other site 357808006077 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 357808006078 putative deacylase active site [active] 357808006079 Dodecin; Region: Dodecin; pfam07311 357808006080 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 357808006081 GAF domain; Region: GAF; cl17456 357808006082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808006083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808006084 dimer interface [polypeptide binding]; other site 357808006085 phosphorylation site [posttranslational modification] 357808006086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808006087 ATP binding site [chemical binding]; other site 357808006088 Mg2+ binding site [ion binding]; other site 357808006089 G-X-G motif; other site 357808006090 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 357808006091 Rubrerythrin [Energy production and conversion]; Region: COG1592 357808006092 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 357808006093 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 357808006094 active site 357808006095 metal binding site [ion binding]; metal-binding site 357808006096 CpXC protein; Region: CpXC; pfam14353 357808006097 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 357808006098 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 357808006099 acyl-activating enzyme (AAE) consensus motif; other site 357808006100 putative AMP binding site [chemical binding]; other site 357808006101 putative active site [active] 357808006102 putative CoA binding site [chemical binding]; other site 357808006103 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357808006104 AsnC family; Region: AsnC_trans_reg; pfam01037 357808006105 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 357808006106 TrkA-N domain; Region: TrkA_N; pfam02254 357808006107 TrkA-C domain; Region: TrkA_C; pfam02080 357808006108 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 357808006109 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 357808006110 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 357808006111 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357808006112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357808006113 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 357808006114 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 357808006115 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 357808006116 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 357808006117 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 357808006118 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 357808006119 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 357808006120 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 357808006121 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 357808006122 acyl-activating enzyme (AAE) consensus motif; other site 357808006123 putative AMP binding site [chemical binding]; other site 357808006124 putative active site [active] 357808006125 putative CoA binding site [chemical binding]; other site 357808006126 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 357808006127 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 357808006128 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 357808006129 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 357808006130 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357808006131 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659 357808006132 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 357808006133 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 357808006134 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357808006135 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 357808006136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357808006137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357808006138 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357808006139 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 357808006140 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 357808006141 E3 interaction surface; other site 357808006142 lipoyl attachment site [posttranslational modification]; other site 357808006143 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 357808006144 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357808006145 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357808006146 Walker A/P-loop; other site 357808006147 ATP binding site [chemical binding]; other site 357808006148 Q-loop/lid; other site 357808006149 ABC transporter signature motif; other site 357808006150 Walker B; other site 357808006151 D-loop; other site 357808006152 H-loop/switch region; other site 357808006153 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357808006154 Ligand Binding Site [chemical binding]; other site 357808006155 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357808006156 Ligand Binding Site [chemical binding]; other site 357808006157 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357808006158 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357808006159 Walker A/P-loop; other site 357808006160 ATP binding site [chemical binding]; other site 357808006161 Q-loop/lid; other site 357808006162 ABC transporter signature motif; other site 357808006163 Walker B; other site 357808006164 D-loop; other site 357808006165 H-loop/switch region; other site 357808006166 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 357808006167 antiporter inner membrane protein; Provisional; Region: PRK11670 357808006168 Domain of unknown function DUF59; Region: DUF59; pfam01883 357808006169 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 357808006170 Walker A motif; other site 357808006171 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 357808006172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808006173 FeS/SAM binding site; other site 357808006174 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 357808006175 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 357808006176 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 357808006177 active site residue [active] 357808006178 Domain of unknown function (DUF309); Region: DUF309; pfam03745 357808006179 Trm112p-like protein; Region: Trm112p; pfam03966 357808006180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357808006181 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 357808006182 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 357808006183 DNA binding residues [nucleotide binding] 357808006184 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 357808006185 B12 binding domain; Region: B12-binding_2; pfam02607 357808006186 B12 binding domain; Region: B12-binding; pfam02310 357808006187 B12 binding site [chemical binding]; other site 357808006188 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 357808006189 active site lid residues [active] 357808006190 substrate binding pocket [chemical binding]; other site 357808006191 catalytic residues [active] 357808006192 substrate-Mg2+ binding site; other site 357808006193 aspartate-rich region 1; other site 357808006194 aspartate-rich region 2; other site 357808006195 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 357808006196 TIGR01777 family protein; Region: yfcH 357808006197 putative NAD(P) binding site [chemical binding]; other site 357808006198 putative active site [active] 357808006199 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 357808006200 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 357808006201 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357808006202 protein binding site [polypeptide binding]; other site 357808006203 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 357808006204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357808006205 Walker A motif; other site 357808006206 ATP binding site [chemical binding]; other site 357808006207 Walker B motif; other site 357808006208 arginine finger; other site 357808006209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 357808006210 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502 357808006211 active site 357808006212 catalytic triad [active] 357808006213 oxyanion hole [active] 357808006214 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 357808006215 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 357808006216 Divergent AAA domain; Region: AAA_4; pfam04326 357808006217 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 357808006218 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 357808006219 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 357808006220 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357808006221 active site 357808006222 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 357808006223 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 357808006224 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357808006225 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357808006226 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 357808006227 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357808006228 catalytic core [active] 357808006229 GMP synthase; Reviewed; Region: guaA; PRK00074 357808006230 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 357808006231 AMP/PPi binding site [chemical binding]; other site 357808006232 candidate oxyanion hole; other site 357808006233 catalytic triad [active] 357808006234 potential glutamine specificity residues [chemical binding]; other site 357808006235 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 357808006236 ATP Binding subdomain [chemical binding]; other site 357808006237 Ligand Binding sites [chemical binding]; other site 357808006238 Dimerization subdomain; other site 357808006239 Helix-turn-helix domain; Region: HTH_17; pfam12728 357808006240 Sensory domain found in PocR; Region: PocR; pfam10114 357808006241 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 357808006242 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 357808006243 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357808006244 FAD binding domain; Region: FAD_binding_4; pfam01565 357808006245 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 357808006246 Cysteine-rich domain; Region: CCG; pfam02754 357808006247 Cysteine-rich domain; Region: CCG; pfam02754 357808006248 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 357808006249 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 357808006250 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 357808006251 Ligand Binding Site [chemical binding]; other site 357808006252 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 357808006253 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 357808006254 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 357808006255 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 357808006256 G1 box; other site 357808006257 GTP/Mg2+ binding site [chemical binding]; other site 357808006258 G2 box; other site 357808006259 Switch I region; other site 357808006260 G3 box; other site 357808006261 Switch II region; other site 357808006262 G4 box; other site 357808006263 G5 box; other site 357808006264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357808006265 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357808006266 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 357808006267 Protein of unknown function (DUF512); Region: DUF512; pfam04459 357808006268 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808006269 GAF domain; Region: GAF_2; pfam13185 357808006270 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808006271 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808006272 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 357808006273 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357808006274 Zn2+ binding site [ion binding]; other site 357808006275 Mg2+ binding site [ion binding]; other site 357808006276 GTP-binding protein Der; Reviewed; Region: PRK00093 357808006277 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 357808006278 G1 box; other site 357808006279 GTP/Mg2+ binding site [chemical binding]; other site 357808006280 Switch I region; other site 357808006281 G2 box; other site 357808006282 Switch II region; other site 357808006283 G3 box; other site 357808006284 G4 box; other site 357808006285 G5 box; other site 357808006286 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 357808006287 G1 box; other site 357808006288 GTP/Mg2+ binding site [chemical binding]; other site 357808006289 Switch I region; other site 357808006290 G2 box; other site 357808006291 G3 box; other site 357808006292 Switch II region; other site 357808006293 G4 box; other site 357808006294 G5 box; other site 357808006295 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808006296 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808006297 phosphopeptide binding site; other site 357808006298 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 357808006299 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 357808006300 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 357808006301 Catalytic site [active] 357808006302 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 357808006303 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808006304 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 357808006305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 357808006306 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 357808006307 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 357808006308 active site 357808006309 ATP binding site [chemical binding]; other site 357808006310 substrate binding site [chemical binding]; other site 357808006311 activation loop (A-loop); other site 357808006312 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 357808006313 structural tetrad; other site 357808006314 FOG: WD40 repeat [General function prediction only]; Region: COG2319 357808006315 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 357808006316 structural tetrad; other site 357808006317 phytoene desaturase; Region: crtI_fam; TIGR02734 357808006318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357808006319 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 357808006320 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357808006321 putative catalytic residue [active] 357808006322 Uncharacterized conserved protein [Function unknown]; Region: COG0432 357808006323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 357808006324 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 357808006325 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 357808006326 anti sigma factor interaction site; other site 357808006327 regulatory phosphorylation site [posttranslational modification]; other site 357808006328 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 357808006329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 357808006330 ATP binding site [chemical binding]; other site 357808006331 Mg2+ binding site [ion binding]; other site 357808006332 G-X-G motif; other site 357808006333 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 357808006334 anti sigma factor interaction site; other site 357808006335 regulatory phosphorylation site [posttranslational modification]; other site 357808006336 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808006337 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808006338 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808006339 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 357808006340 GAF domain; Region: GAF_3; pfam13492 357808006341 GAF domain; Region: GAF_2; pfam13185 357808006342 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 357808006343 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 357808006344 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 357808006345 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 357808006346 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 357808006347 nucleophile elbow; other site 357808006348 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 357808006349 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 357808006350 metal ion-dependent adhesion site (MIDAS); other site 357808006351 MoxR-like ATPases [General function prediction only]; Region: COG0714 357808006352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357808006353 Tic20-like protein; Region: Tic20; pfam09685 357808006354 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 357808006355 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 357808006356 trimer interface [polypeptide binding]; other site 357808006357 putative metal binding site [ion binding]; other site 357808006358 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 357808006359 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 357808006360 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357808006361 AAA domain; Region: AAA_23; pfam13476 357808006362 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357808006363 P-loop; other site 357808006364 Magnesium ion binding site [ion binding]; other site 357808006365 HEPN domain; Region: HEPN; pfam05168 357808006366 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 357808006367 amidase catalytic site [active] 357808006368 Zn binding residues [ion binding]; other site 357808006369 substrate binding site [chemical binding]; other site 357808006370 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 357808006371 CHAT domain; Region: CHAT; cl17868 357808006372 Helix-turn-helix domain; Region: HTH_28; pfam13518 357808006373 Winged helix-turn helix; Region: HTH_29; pfam13551 357808006374 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808006375 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808006376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808006377 putative substrate translocation pore; other site 357808006378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808006379 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 357808006380 GTPase Era; Reviewed; Region: era; PRK00089 357808006381 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 357808006382 G1 box; other site 357808006383 GTP/Mg2+ binding site [chemical binding]; other site 357808006384 Switch I region; other site 357808006385 G2 box; other site 357808006386 Switch II region; other site 357808006387 G3 box; other site 357808006388 G4 box; other site 357808006389 G5 box; other site 357808006390 KH domain; Region: KH_2; pfam07650 357808006391 DNA methylase; Region: N6_N4_Mtase; pfam01555 357808006392 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 357808006393 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 357808006394 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 357808006395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808006396 S-adenosylmethionine binding site [chemical binding]; other site 357808006397 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 357808006398 nucleotide binding site [chemical binding]; other site 357808006399 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 357808006400 active site 357808006401 homotetramer interface [polypeptide binding]; other site 357808006402 homodimer interface [polypeptide binding]; other site 357808006403 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 357808006404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808006405 S-adenosylmethionine binding site [chemical binding]; other site 357808006406 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808006407 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808006408 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808006409 Bacterial Ig-like domain; Region: Big_5; pfam13205 357808006410 Bacterial Ig-like domain; Region: Big_5; pfam13205 357808006411 Bacterial Ig-like domain; Region: Big_5; pfam13205 357808006412 Bacterial Ig-like domain; Region: Big_5; pfam13205 357808006413 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 357808006414 MG2 domain; Region: A2M_N; pfam01835 357808006415 Alpha-2-macroglobulin family; Region: A2M; pfam00207 357808006416 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 357808006417 surface patch; other site 357808006418 thioester region; other site 357808006419 specificity defining residues; other site 357808006420 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808006421 active site 357808006422 NTP binding site [chemical binding]; other site 357808006423 metal binding triad [ion binding]; metal-binding site 357808006424 antibiotic binding site [chemical binding]; other site 357808006425 HEPN domain; Region: HEPN; pfam05168 357808006426 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 357808006427 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357808006428 active site 357808006429 metal binding site [ion binding]; metal-binding site 357808006430 DNA binding site [nucleotide binding] 357808006431 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 357808006432 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 357808006433 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 357808006434 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 357808006435 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357808006436 Walker A motif; other site 357808006437 ATP binding site [chemical binding]; other site 357808006438 Walker B motif; other site 357808006439 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 357808006440 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357808006441 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 357808006442 Walker A motif; other site 357808006443 ATP binding site [chemical binding]; other site 357808006444 Walker B motif; other site 357808006445 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357808006446 active site 357808006447 HIGH motif; other site 357808006448 nucleotide binding site [chemical binding]; other site 357808006449 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 357808006450 Peptidase family M23; Region: Peptidase_M23; pfam01551 357808006451 AAA-like domain; Region: AAA_10; pfam12846 357808006452 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 357808006453 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 357808006454 homodimer interface [polypeptide binding]; other site 357808006455 substrate-cofactor binding pocket; other site 357808006456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808006457 catalytic residue [active] 357808006458 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 357808006459 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 357808006460 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 357808006461 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 357808006462 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 357808006463 active site 357808006464 (T/H)XGH motif; other site 357808006465 autolysin; Reviewed; Region: PRK06347 357808006466 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 357808006467 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 357808006468 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 357808006469 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 357808006470 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808006471 putative active site [active] 357808006472 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 357808006473 Part of AAA domain; Region: AAA_19; pfam13245 357808006474 Family description; Region: UvrD_C_2; pfam13538 357808006475 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 357808006476 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 357808006477 catalytic site [active] 357808006478 TAP-like protein; Region: Abhydrolase_4; pfam08386 357808006479 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 357808006480 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808006481 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808006482 active site 357808006483 ATP binding site [chemical binding]; other site 357808006484 substrate binding site [chemical binding]; other site 357808006485 activation loop (A-loop); other site 357808006486 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 357808006487 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 357808006488 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357808006489 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 357808006490 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357808006491 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 357808006492 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 357808006493 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357808006494 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 357808006495 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 357808006496 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 357808006497 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 357808006498 4Fe-4S binding domain; Region: Fer4; pfam00037 357808006499 4Fe-4S binding domain; Region: Fer4; pfam00037 357808006500 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 357808006501 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 357808006502 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 357808006503 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357808006504 catalytic loop [active] 357808006505 iron binding site [ion binding]; other site 357808006506 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 357808006507 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357808006508 molybdopterin cofactor binding site; other site 357808006509 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 357808006510 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 357808006511 SLBB domain; Region: SLBB; pfam10531 357808006512 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 357808006513 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808006514 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808006515 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 357808006516 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808006517 putative active site [active] 357808006518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808006519 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357808006520 putative substrate translocation pore; other site 357808006521 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357808006522 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 357808006523 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 357808006524 putative active site [active] 357808006525 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 357808006526 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 357808006527 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 357808006528 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 357808006529 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808006530 AAK_FomA-like: This CD includes a fosfomycin biosynthetic gene product, FomA, and similar proteins found in a wide range of organisms. Together, the fomA and fomB genes in the fosfomycin biosynthetic gene cluster of Streptomyces wedmorensis confer...; Region: AAK_FomA-like; cd04241 357808006531 putative nucleotide binding site [chemical binding]; other site 357808006532 putative substrate binding site [chemical binding]; other site 357808006533 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 357808006534 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 357808006535 active site 357808006536 dimerization interface [polypeptide binding]; other site 357808006537 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 357808006538 Protein of unknown function (DUF524); Region: DUF524; pfam04411 357808006539 DNA methylase; Region: N6_N4_Mtase; cl17433 357808006540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357808006541 Domain of unknown function (DUF955); Region: DUF955; cl01076 357808006542 HerA helicase [Replication, recombination, and repair]; Region: COG0433 357808006543 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 357808006544 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808006545 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357808006546 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808006547 DNA binding residues [nucleotide binding] 357808006548 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 357808006549 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808006550 ATP binding site [chemical binding]; other site 357808006551 putative Mg++ binding site [ion binding]; other site 357808006552 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808006553 nucleotide binding region [chemical binding]; other site 357808006554 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 357808006555 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 357808006556 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 357808006557 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 357808006558 Part of AAA domain; Region: AAA_19; pfam13245 357808006559 Family description; Region: UvrD_C_2; pfam13538 357808006560 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808006561 putative active site [active] 357808006562 Probable zinc-binding domain; Region: zf-trcl; pfam13451 357808006563 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 357808006564 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 357808006565 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 357808006566 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 357808006567 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 357808006568 Cytochrome c; Region: Cytochrom_C; cl11414 357808006569 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 357808006570 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 357808006571 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 357808006572 D-pathway; other site 357808006573 Putative ubiquinol binding site [chemical binding]; other site 357808006574 Low-spin heme (heme b) binding site [chemical binding]; other site 357808006575 Putative water exit pathway; other site 357808006576 Binuclear center (heme o3/CuB) [ion binding]; other site 357808006577 K-pathway; other site 357808006578 Putative proton exit pathway; other site 357808006579 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 357808006580 Subunit I/III interface [polypeptide binding]; other site 357808006581 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 357808006582 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 357808006583 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 357808006584 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 357808006585 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357808006586 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357808006587 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 357808006588 Walker A/P-loop; other site 357808006589 ATP binding site [chemical binding]; other site 357808006590 Q-loop/lid; other site 357808006591 ABC transporter signature motif; other site 357808006592 Walker B; other site 357808006593 D-loop; other site 357808006594 H-loop/switch region; other site 357808006595 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 357808006596 Putative phosphatase (DUF442); Region: DUF442; cl17385 357808006597 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 357808006598 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357808006599 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357808006600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808006601 Walker A/P-loop; other site 357808006602 ATP binding site [chemical binding]; other site 357808006603 Q-loop/lid; other site 357808006604 ABC transporter signature motif; other site 357808006605 Walker B; other site 357808006606 D-loop; other site 357808006607 H-loop/switch region; other site 357808006608 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 357808006609 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 357808006610 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 357808006611 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 357808006612 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 357808006613 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 357808006614 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 357808006615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808006616 S-adenosylmethionine binding site [chemical binding]; other site 357808006617 prolyl-tRNA synthetase; Provisional; Region: PRK09194 357808006618 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 357808006619 motif 1; other site 357808006620 dimer interface [polypeptide binding]; other site 357808006621 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 357808006622 putative deacylase active site [active] 357808006623 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 357808006624 anticodon binding site; other site 357808006625 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 357808006626 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 357808006627 catalytic residues [active] 357808006628 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808006629 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808006630 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808006631 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808006632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808006633 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808006634 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 357808006635 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 357808006636 adhesin; Provisional; Region: PRK09752 357808006637 DNA methylase; Region: N6_N4_Mtase; cl17433 357808006638 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 357808006639 gating phenylalanine in ion channel; other site 357808006640 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 357808006641 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 357808006642 Malic enzyme, N-terminal domain; Region: malic; pfam00390 357808006643 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 357808006644 putative NAD(P) binding site [chemical binding]; other site 357808006645 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 357808006646 Peptidase family M23; Region: Peptidase_M23; pfam01551 357808006647 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808006648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808006649 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808006650 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 357808006651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808006652 NAD(P) binding site [chemical binding]; other site 357808006653 active site 357808006654 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808006655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808006656 active site 357808006657 phosphorylation site [posttranslational modification] 357808006658 intermolecular recognition site; other site 357808006659 dimerization interface [polypeptide binding]; other site 357808006660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808006661 DNA binding site [nucleotide binding] 357808006662 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 357808006663 Domain of unknown function DUF20; Region: UPF0118; pfam01594 357808006664 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 357808006665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808006666 dimer interface [polypeptide binding]; other site 357808006667 conserved gate region; other site 357808006668 ABC-ATPase subunit interface; other site 357808006669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808006670 dimer interface [polypeptide binding]; other site 357808006671 conserved gate region; other site 357808006672 putative PBP binding loops; other site 357808006673 ABC-ATPase subunit interface; other site 357808006674 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 357808006675 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 357808006676 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808006677 GAF domain; Region: GAF; pfam01590 357808006678 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808006679 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808006680 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357808006681 PAS domain; Region: PAS; smart00091 357808006682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808006683 dimer interface [polypeptide binding]; other site 357808006684 phosphorylation site [posttranslational modification] 357808006685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808006686 ATP binding site [chemical binding]; other site 357808006687 Mg2+ binding site [ion binding]; other site 357808006688 G-X-G motif; other site 357808006689 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 357808006690 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 357808006691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808006692 ATP binding site [chemical binding]; other site 357808006693 Mg2+ binding site [ion binding]; other site 357808006694 G-X-G motif; other site 357808006695 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 357808006696 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 357808006697 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 357808006698 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 357808006699 Ligand binding site [chemical binding]; other site 357808006700 Electron transfer flavoprotein domain; Region: ETF; pfam01012 357808006701 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357808006702 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357808006703 active site 357808006704 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 357808006705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808006706 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 357808006707 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357808006708 substrate binding site [chemical binding]; other site 357808006709 oxyanion hole (OAH) forming residues; other site 357808006710 trimer interface [polypeptide binding]; other site 357808006711 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 357808006712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808006713 NAD(P) binding site [chemical binding]; other site 357808006714 active site 357808006715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808006716 PAS domain; Region: PAS_9; pfam13426 357808006717 putative active site [active] 357808006718 heme pocket [chemical binding]; other site 357808006719 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808006720 PAS domain; Region: PAS_9; pfam13426 357808006721 putative active site [active] 357808006722 heme pocket [chemical binding]; other site 357808006723 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 357808006724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808006725 putative active site [active] 357808006726 heme pocket [chemical binding]; other site 357808006727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808006728 phosphorylation site [posttranslational modification] 357808006729 dimer interface [polypeptide binding]; other site 357808006730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808006731 ATP binding site [chemical binding]; other site 357808006732 Mg2+ binding site [ion binding]; other site 357808006733 G-X-G motif; other site 357808006734 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808006735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808006736 active site 357808006737 phosphorylation site [posttranslational modification] 357808006738 intermolecular recognition site; other site 357808006739 dimerization interface [polypeptide binding]; other site 357808006740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808006741 DNA binding site [nucleotide binding] 357808006742 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 357808006743 ligand binding site [chemical binding]; other site 357808006744 dimerization interface (open form) [polypeptide binding]; other site 357808006745 dimerization interface (closed form) [polypeptide binding]; other site 357808006746 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357808006747 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808006748 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 357808006749 Peptidase family M50; Region: Peptidase_M50; pfam02163 357808006750 active site 357808006751 putative substrate binding region [chemical binding]; other site 357808006752 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 357808006753 FOG: CBS domain [General function prediction only]; Region: COG0517 357808006754 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 357808006755 active site 357808006756 catalytic residues [active] 357808006757 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 357808006758 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 357808006759 structural tetrad; other site 357808006760 carboxyl-terminal processing protease; Provisional; Region: PLN00049 357808006761 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 357808006762 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 357808006763 protein binding site [polypeptide binding]; other site 357808006764 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 357808006765 Domain interface; other site 357808006766 Peptide binding site; other site 357808006767 Active site tetrad [active] 357808006768 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357808006769 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357808006770 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357808006771 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357808006772 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357808006773 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357808006774 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357808006775 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357808006776 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357808006777 HlyD family secretion protein; Region: HlyD_3; pfam13437 357808006778 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 357808006779 FtsX-like permease family; Region: FtsX; pfam02687 357808006780 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357808006781 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357808006782 Walker A/P-loop; other site 357808006783 ATP binding site [chemical binding]; other site 357808006784 Q-loop/lid; other site 357808006785 ABC transporter signature motif; other site 357808006786 Walker B; other site 357808006787 D-loop; other site 357808006788 H-loop/switch region; other site 357808006789 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357808006790 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357808006791 Walker A/P-loop; other site 357808006792 ATP binding site [chemical binding]; other site 357808006793 Q-loop/lid; other site 357808006794 ABC transporter signature motif; other site 357808006795 Walker B; other site 357808006796 D-loop; other site 357808006797 H-loop/switch region; other site 357808006798 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 357808006799 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 357808006800 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 357808006801 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 357808006802 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 357808006803 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 357808006804 putative substrate-binding site; other site 357808006805 nickel binding site [ion binding]; other site 357808006806 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 357808006807 Protein of unknown function (DUF2281); Region: DUF2281; pfam10047 357808006808 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 357808006809 putative active site [active] 357808006810 PIN domain; Region: PIN_3; pfam13470 357808006811 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 357808006812 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 357808006813 HflX GTPase family; Region: HflX; cd01878 357808006814 G1 box; other site 357808006815 GTP/Mg2+ binding site [chemical binding]; other site 357808006816 Switch I region; other site 357808006817 G2 box; other site 357808006818 G3 box; other site 357808006819 Switch II region; other site 357808006820 G4 box; other site 357808006821 G5 box; other site 357808006822 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357808006823 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 357808006824 catalytic site [active] 357808006825 TAP-like protein; Region: Abhydrolase_4; pfam08386 357808006826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808006827 S-adenosylmethionine binding site [chemical binding]; other site 357808006828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357808006829 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 357808006830 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 357808006831 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 357808006832 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 357808006833 active site 357808006834 PHP-associated; Region: PHP_C; pfam13263 357808006835 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808006836 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 357808006837 Uncharacterized conserved protein [Function unknown]; Region: COG0398 357808006838 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 357808006839 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357808006840 active site 357808006841 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 357808006842 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 357808006843 Response regulator receiver domain; Region: Response_reg; pfam00072 357808006844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808006845 active site 357808006846 phosphorylation site [posttranslational modification] 357808006847 intermolecular recognition site; other site 357808006848 dimerization interface [polypeptide binding]; other site 357808006849 PAS domain; Region: PAS_8; pfam13188 357808006850 PAS domain; Region: PAS_9; pfam13426 357808006851 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808006852 PAS fold; Region: PAS_3; pfam08447 357808006853 putative active site [active] 357808006854 heme pocket [chemical binding]; other site 357808006855 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357808006856 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357808006857 metal binding site [ion binding]; metal-binding site 357808006858 active site 357808006859 I-site; other site 357808006860 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357808006861 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 357808006862 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357808006863 ligand binding site [chemical binding]; other site 357808006864 dimerization interface [polypeptide binding]; other site 357808006865 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808006866 dimer interface [polypeptide binding]; other site 357808006867 phosphorylation site [posttranslational modification] 357808006868 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808006869 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808006870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808006871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808006872 ATP binding site [chemical binding]; other site 357808006873 Mg2+ binding site [ion binding]; other site 357808006874 G-X-G motif; other site 357808006875 Response regulator receiver domain; Region: Response_reg; pfam00072 357808006876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808006877 active site 357808006878 phosphorylation site [posttranslational modification] 357808006879 intermolecular recognition site; other site 357808006880 dimerization interface [polypeptide binding]; other site 357808006881 Response regulator receiver domain; Region: Response_reg; pfam00072 357808006882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808006883 active site 357808006884 phosphorylation site [posttranslational modification] 357808006885 intermolecular recognition site; other site 357808006886 dimerization interface [polypeptide binding]; other site 357808006887 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 357808006888 Domain of unknown function DUF11; Region: DUF11; pfam01345 357808006889 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 357808006890 PspC domain; Region: PspC; pfam04024 357808006891 CodY GAF-like domain; Region: CodY; pfam06018 357808006892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808006893 ATP binding site [chemical binding]; other site 357808006894 Mg2+ binding site [ion binding]; other site 357808006895 G-X-G motif; other site 357808006896 transcriptional regulator MalT; Provisional; Region: PRK04841 357808006897 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808006898 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808006899 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808006900 binding surface 357808006901 TPR motif; other site 357808006902 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808006903 Bacterial transcriptional activator domain; Region: BTAD; smart01043 357808006904 Esterase/lipase [General function prediction only]; Region: COG1647 357808006905 Family description; Region: VCBS; pfam13517 357808006906 Family description; Region: VCBS; pfam13517 357808006907 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 357808006908 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 357808006909 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 357808006910 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 357808006911 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 357808006912 homotrimer interaction site [polypeptide binding]; other site 357808006913 active site 357808006914 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 357808006915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808006916 active site 357808006917 phosphorylation site [posttranslational modification] 357808006918 intermolecular recognition site; other site 357808006919 dimerization interface [polypeptide binding]; other site 357808006920 ANTAR domain; Region: ANTAR; pfam03861 357808006921 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357808006922 Beta-lactamase; Region: Beta-lactamase; pfam00144 357808006923 Right handed beta helix region; Region: Beta_helix; pfam13229 357808006924 GAF domain; Region: GAF_3; pfam13492 357808006925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808006926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808006927 dimer interface [polypeptide binding]; other site 357808006928 phosphorylation site [posttranslational modification] 357808006929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808006930 ATP binding site [chemical binding]; other site 357808006931 Mg2+ binding site [ion binding]; other site 357808006932 G-X-G motif; other site 357808006933 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 357808006934 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 357808006935 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 357808006936 dimer interface [polypeptide binding]; other site 357808006937 active site 357808006938 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 357808006939 dimer interface [polypeptide binding]; other site 357808006940 active site 357808006941 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357808006942 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357808006943 active site 357808006944 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357808006945 I-site; other site 357808006946 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 357808006947 Bacterial sugar transferase; Region: Bac_transf; pfam02397 357808006948 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 357808006949 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 357808006950 putative ADP-binding pocket [chemical binding]; other site 357808006951 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808006952 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808006953 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 357808006954 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357808006955 DXD motif; other site 357808006956 Chain length determinant protein; Region: Wzz; pfam02706 357808006957 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 357808006958 O-Antigen ligase; Region: Wzy_C; pfam04932 357808006959 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 357808006960 active site 357808006961 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 357808006962 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 357808006963 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 357808006964 active site 357808006965 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808006966 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 357808006967 putative ADP-binding pocket [chemical binding]; other site 357808006968 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808006969 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808006970 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 357808006971 dimer interface [polypeptide binding]; other site 357808006972 active site 357808006973 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 357808006974 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 357808006975 active site 357808006976 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 357808006977 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 357808006978 active site 357808006979 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 357808006980 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 357808006981 substrate binding site; other site 357808006982 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357808006983 extended (e) SDRs; Region: SDR_e; cd08946 357808006984 NAD(P) binding site [chemical binding]; other site 357808006985 active site 357808006986 substrate binding site [chemical binding]; other site 357808006987 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 357808006988 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808006989 Methyltransferase domain; Region: Methyltransf_12; pfam08242 357808006990 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 357808006991 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808006992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808006993 S-adenosylmethionine binding site [chemical binding]; other site 357808006994 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 357808006995 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 357808006996 Interdomain contacts; other site 357808006997 Cytokine receptor motif; other site 357808006998 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 357808006999 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808007000 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808007001 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808007002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808007003 S-adenosylmethionine binding site [chemical binding]; other site 357808007004 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 357808007005 TM1410 hypothetical-related protein; Region: DUF297; cl00997 357808007006 adhesin; Provisional; Region: PRK09752 357808007007 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 357808007008 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 357808007009 tandem repeat interface [polypeptide binding]; other site 357808007010 oligomer interface [polypeptide binding]; other site 357808007011 active site residues [active] 357808007012 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 357808007013 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 357808007014 NAD binding site [chemical binding]; other site 357808007015 substrate binding site [chemical binding]; other site 357808007016 homodimer interface [polypeptide binding]; other site 357808007017 active site 357808007018 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 357808007019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808007020 NAD(P) binding site [chemical binding]; other site 357808007021 active site 357808007022 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 357808007023 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 357808007024 Methyltransferase domain; Region: Methyltransf_26; pfam13659 357808007025 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 357808007026 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 357808007027 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 357808007028 L-aspartate oxidase; Provisional; Region: PRK06175 357808007029 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 357808007030 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 357808007031 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 357808007032 putative Iron-sulfur protein interface [polypeptide binding]; other site 357808007033 proximal heme binding site [chemical binding]; other site 357808007034 distal heme binding site [chemical binding]; other site 357808007035 putative dimer interface [polypeptide binding]; other site 357808007036 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 357808007037 Low molecular weight phosphatase family; Region: LMWPc; cl00105 357808007038 active site 357808007039 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357808007040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808007041 putative active site [active] 357808007042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808007043 dimer interface [polypeptide binding]; other site 357808007044 phosphorylation site [posttranslational modification] 357808007045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808007046 ATP binding site [chemical binding]; other site 357808007047 Mg2+ binding site [ion binding]; other site 357808007048 G-X-G motif; other site 357808007049 argininosuccinate lyase; Provisional; Region: PRK00855 357808007050 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 357808007051 active sites [active] 357808007052 tetramer interface [polypeptide binding]; other site 357808007053 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808007054 putative active site [active] 357808007055 ornithine carbamoyltransferase; Provisional; Region: PRK00779 357808007056 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 357808007057 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 357808007058 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 357808007059 TrkA-N domain; Region: TrkA_N; pfam02254 357808007060 TrkA-C domain; Region: TrkA_C; pfam02080 357808007061 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 357808007062 TrkA-N domain; Region: TrkA_N; pfam02254 357808007063 TrkA-C domain; Region: TrkA_C; pfam02080 357808007064 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 357808007065 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 357808007066 oligomer interface [polypeptide binding]; other site 357808007067 metal binding site [ion binding]; metal-binding site 357808007068 metal binding site [ion binding]; metal-binding site 357808007069 putative Cl binding site [ion binding]; other site 357808007070 aspartate ring; other site 357808007071 basic sphincter; other site 357808007072 hydrophobic gate; other site 357808007073 periplasmic entrance; other site 357808007074 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 357808007075 putative ligand binding pocket/active site [active] 357808007076 putative metal binding site [ion binding]; other site 357808007077 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 357808007078 30S subunit binding site; other site 357808007079 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 357808007080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808007081 NAD(P) binding site [chemical binding]; other site 357808007082 active site 357808007083 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 357808007084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 357808007085 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808007086 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808007087 Histidine kinase; Region: HisKA_3; pfam07730 357808007088 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 357808007089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808007090 ATP binding site [chemical binding]; other site 357808007091 Mg2+ binding site [ion binding]; other site 357808007092 G-X-G motif; other site 357808007093 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 357808007094 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 357808007095 tetramer interface [polypeptide binding]; other site 357808007096 TPP-binding site [chemical binding]; other site 357808007097 heterodimer interface [polypeptide binding]; other site 357808007098 phosphorylation loop region [posttranslational modification] 357808007099 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 357808007100 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 357808007101 alpha subunit interface [polypeptide binding]; other site 357808007102 TPP binding site [chemical binding]; other site 357808007103 heterodimer interface [polypeptide binding]; other site 357808007104 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 357808007105 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 357808007106 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357808007107 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357808007108 Walker A/P-loop; other site 357808007109 ATP binding site [chemical binding]; other site 357808007110 Q-loop/lid; other site 357808007111 ABC transporter signature motif; other site 357808007112 Walker B; other site 357808007113 D-loop; other site 357808007114 H-loop/switch region; other site 357808007115 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 357808007116 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808007117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808007118 S-adenosylmethionine binding site [chemical binding]; other site 357808007119 Methyltransferase domain; Region: Methyltransf_11; pfam08241 357808007120 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 357808007121 methionine sulfoxide reductase B; Provisional; Region: PRK00222 357808007122 SelR domain; Region: SelR; pfam01641 357808007123 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 357808007124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808007125 Walker A motif; other site 357808007126 ATP binding site [chemical binding]; other site 357808007127 Walker B motif; other site 357808007128 arginine finger; other site 357808007129 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 357808007130 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 357808007131 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 357808007132 active site 357808007133 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357808007134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808007135 Coenzyme A binding pocket [chemical binding]; other site 357808007136 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 357808007137 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 357808007138 catalytic triad [active] 357808007139 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 357808007140 dimer interface [polypeptide binding]; other site 357808007141 ADP-ribose binding site [chemical binding]; other site 357808007142 active site 357808007143 nudix motif; other site 357808007144 metal binding site [ion binding]; metal-binding site 357808007145 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 357808007146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808007147 FeS/SAM binding site; other site 357808007148 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357808007149 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357808007150 Walker A/P-loop; other site 357808007151 ATP binding site [chemical binding]; other site 357808007152 Q-loop/lid; other site 357808007153 ABC transporter signature motif; other site 357808007154 Walker B; other site 357808007155 D-loop; other site 357808007156 H-loop/switch region; other site 357808007157 Yip1 domain; Region: Yip1; pfam04893 357808007158 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 357808007159 HSP70 interaction site [polypeptide binding]; other site 357808007160 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 357808007161 Double zinc ribbon; Region: DZR; pfam12773 357808007162 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808007163 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808007164 phosphopeptide binding site; other site 357808007165 recombination protein F; Reviewed; Region: recF; PRK00064 357808007166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808007167 Walker A/P-loop; other site 357808007168 ATP binding site [chemical binding]; other site 357808007169 Q-loop/lid; other site 357808007170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808007171 ABC transporter signature motif; other site 357808007172 Walker B; other site 357808007173 D-loop; other site 357808007174 H-loop/switch region; other site 357808007175 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 357808007176 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 357808007177 homotetramer interface [polypeptide binding]; other site 357808007178 FMN binding site [chemical binding]; other site 357808007179 homodimer contacts [polypeptide binding]; other site 357808007180 putative active site [active] 357808007181 putative substrate binding site [chemical binding]; other site 357808007182 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 357808007183 active site 357808007184 MutL protein; Region: MutL; pfam13941 357808007185 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 357808007186 putative active site [active] 357808007187 dimerization interface [polypeptide binding]; other site 357808007188 putative tRNAtyr binding site [nucleotide binding]; other site 357808007189 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 357808007190 CoenzymeA binding site [chemical binding]; other site 357808007191 subunit interaction site [polypeptide binding]; other site 357808007192 PHB binding site; other site 357808007193 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 357808007194 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 357808007195 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 357808007196 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 357808007197 homodimer interface [polypeptide binding]; other site 357808007198 putative GKAP docking site [polypeptide binding]; other site 357808007199 Bacterial SH3 domain; Region: SH3_3; cl17532 357808007200 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 357808007201 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 357808007202 Chromate transporter; Region: Chromate_transp; pfam02417 357808007203 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 357808007204 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 357808007205 metal-binding site [ion binding] 357808007206 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357808007207 Soluble P-type ATPase [General function prediction only]; Region: COG4087 357808007208 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 357808007209 Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; Region: Peptidase_C1A; cd02248 357808007210 active site 357808007211 S2 subsite; other site 357808007212 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808007213 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808007214 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808007215 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808007216 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808007217 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808007218 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808007219 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808007220 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808007221 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808007222 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 357808007223 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 357808007224 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 357808007225 homodimer interface [polypeptide binding]; other site 357808007226 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 357808007227 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 357808007228 active site 357808007229 homodimer interface [polypeptide binding]; other site 357808007230 catalytic site [active] 357808007231 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 357808007232 Interdomain contacts; other site 357808007233 Cytokine receptor motif; other site 357808007234 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 357808007235 Interdomain contacts; other site 357808007236 Cytokine receptor motif; other site 357808007237 Starch binding domain; Region: CBM_2; smart01065 357808007238 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808007239 active site 357808007240 NTP binding site [chemical binding]; other site 357808007241 metal binding triad [ion binding]; metal-binding site 357808007242 antibiotic binding site [chemical binding]; other site 357808007243 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 357808007244 PspC domain; Region: PspC; pfam04024 357808007245 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 357808007246 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 357808007247 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 357808007248 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 357808007249 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 357808007250 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 357808007251 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 357808007252 asparagine synthetase B; Provisional; Region: asnB; PRK09431 357808007253 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 357808007254 active site 357808007255 dimer interface [polypeptide binding]; other site 357808007256 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 357808007257 Ligand Binding Site [chemical binding]; other site 357808007258 Molecular Tunnel; other site 357808007259 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 357808007260 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 357808007261 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 357808007262 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 357808007263 dimerization interface [polypeptide binding]; other site 357808007264 DPS ferroxidase diiron center [ion binding]; other site 357808007265 ion pore; other site 357808007266 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 357808007267 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 357808007268 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 357808007269 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808007270 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808007271 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 357808007272 Sterol carrier protein domain; Region: SCP2_2; pfam13530 357808007273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808007274 S-adenosylmethionine binding site [chemical binding]; other site 357808007275 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357808007276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808007277 Coenzyme A binding pocket [chemical binding]; other site 357808007278 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 357808007279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808007280 Walker A/P-loop; other site 357808007281 ATP binding site [chemical binding]; other site 357808007282 Q-loop/lid; other site 357808007283 ABC transporter signature motif; other site 357808007284 Walker B; other site 357808007285 D-loop; other site 357808007286 H-loop/switch region; other site 357808007287 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 357808007288 RNA binding site [nucleotide binding]; other site 357808007289 GTPase RsgA; Reviewed; Region: PRK00098 357808007290 homodimer interface [polypeptide binding]; other site 357808007291 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 357808007292 GTPase/Zn-binding domain interface [polypeptide binding]; other site 357808007293 GTP/Mg2+ binding site [chemical binding]; other site 357808007294 G4 box; other site 357808007295 G5 box; other site 357808007296 G1 box; other site 357808007297 Switch I region; other site 357808007298 G2 box; other site 357808007299 G3 box; other site 357808007300 Switch II region; other site 357808007301 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 357808007302 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357808007303 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 357808007304 ABC-2 type transporter; Region: ABC2_membrane; cl17235 357808007305 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 357808007306 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 357808007307 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 357808007308 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357808007309 Beta-lactamase; Region: Beta-lactamase; pfam00144 357808007310 Predicted dehydrogenase [General function prediction only]; Region: COG5322 357808007311 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 357808007312 NAD(P) binding pocket [chemical binding]; other site 357808007313 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 357808007314 Cytochrome c; Region: Cytochrom_C; pfam00034 357808007315 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357808007316 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 357808007317 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357808007318 Magnesium ion binding site [ion binding]; other site 357808007319 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357808007320 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 357808007321 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 357808007322 phosphopeptide binding site; other site 357808007323 EVE domain; Region: EVE; pfam01878 357808007324 Myosin tail; Region: Myosin_tail_1; pfam01576 357808007325 Protein of unknown function (DUF433); Region: DUF433; pfam04255 357808007326 camphor resistance protein CrcB; Provisional; Region: PRK14215 357808007327 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 357808007328 FOG: CBS domain [General function prediction only]; Region: COG0517 357808007329 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 357808007330 FOG: CBS domain [General function prediction only]; Region: COG0517 357808007331 FOG: CBS domain [General function prediction only]; Region: COG0517 357808007332 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 357808007333 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 357808007334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808007335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808007336 Walker A/P-loop; other site 357808007337 Walker A/P-loop; other site 357808007338 ATP binding site [chemical binding]; other site 357808007339 ATP binding site [chemical binding]; other site 357808007340 Q-loop/lid; other site 357808007341 Q-loop/lid; other site 357808007342 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357808007343 ABC transporter signature motif; other site 357808007344 Walker B; other site 357808007345 D-loop; other site 357808007346 ABC transporter; Region: ABC_tran_2; pfam12848 357808007347 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357808007348 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 357808007349 active site 357808007350 substrate-binding site [chemical binding]; other site 357808007351 metal-binding site [ion binding] 357808007352 GTP binding site [chemical binding]; other site 357808007353 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808007354 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808007355 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808007356 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 357808007357 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 357808007358 GAF domain; Region: GAF; pfam01590 357808007359 GAF domain; Region: GAF_2; pfam13185 357808007360 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808007361 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808007362 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808007363 GAF domain; Region: GAF; pfam01590 357808007364 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808007365 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808007366 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 357808007367 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 357808007368 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 357808007369 nucleoside/Zn binding site; other site 357808007370 dimer interface [polypeptide binding]; other site 357808007371 catalytic motif [active] 357808007372 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808007373 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 357808007374 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808007375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808007376 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357808007377 putative substrate translocation pore; other site 357808007378 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808007379 putative active site [active] 357808007380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808007381 putative substrate translocation pore; other site 357808007382 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357808007383 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 357808007384 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357808007385 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357808007386 metal binding site [ion binding]; metal-binding site 357808007387 active site 357808007388 I-site; other site 357808007389 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808007390 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808007391 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808007392 Family description; Region: VCBS; pfam13517 357808007393 FG-GAP repeat; Region: FG-GAP; cl15299 357808007394 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 357808007395 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 357808007396 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808007397 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808007398 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808007399 hypothetical protein; Provisional; Region: PRK02947 357808007400 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 357808007401 putative active site [active] 357808007402 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 357808007403 classical (c) SDRs; Region: SDR_c; cd05233 357808007404 NAD(P) binding site [chemical binding]; other site 357808007405 active site 357808007406 methionine synthase; Provisional; Region: PRK01207 357808007407 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 357808007408 substrate binding site [chemical binding]; other site 357808007409 THF binding site; other site 357808007410 zinc-binding site [ion binding]; other site 357808007411 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 357808007412 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 357808007413 EamA-like transporter family; Region: EamA; pfam00892 357808007414 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 357808007415 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 357808007416 metal ion-dependent adhesion site (MIDAS); other site 357808007417 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 357808007418 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 357808007419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808007420 catalytic residue [active] 357808007421 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 357808007422 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 357808007423 minor groove reading motif; other site 357808007424 helix-hairpin-helix signature motif; other site 357808007425 substrate binding pocket [chemical binding]; other site 357808007426 active site 357808007427 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 357808007428 magnesium chelatase, H subunit; Region: BchH; TIGR02025 357808007429 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 357808007430 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 357808007431 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 357808007432 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 357808007433 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 357808007434 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808007435 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 357808007436 hydroxyglutarate oxidase; Provisional; Region: PRK11728 357808007437 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808007438 active site 357808007439 NTP binding site [chemical binding]; other site 357808007440 metal binding triad [ion binding]; metal-binding site 357808007441 antibiotic binding site [chemical binding]; other site 357808007442 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808007443 active site 357808007444 NTP binding site [chemical binding]; other site 357808007445 metal binding triad [ion binding]; metal-binding site 357808007446 antibiotic binding site [chemical binding]; other site 357808007447 Uncharacterized conserved protein [Function unknown]; Region: COG2361 357808007448 Putative glucoamylase; Region: Glycoamylase; pfam10091 357808007449 Methyltransferase domain; Region: Methyltransf_26; pfam13659 357808007450 DEAD-like helicases superfamily; Region: DEXDc; smart00487 357808007451 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808007452 ATP binding site [chemical binding]; other site 357808007453 putative Mg++ binding site [ion binding]; other site 357808007454 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808007455 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 357808007456 nucleotide binding region [chemical binding]; other site 357808007457 ATP-binding site [chemical binding]; other site 357808007458 Transposase IS200 like; Region: Y1_Tnp; pfam01797 357808007459 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357808007460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808007461 Walker A/P-loop; other site 357808007462 ATP binding site [chemical binding]; other site 357808007463 Q-loop/lid; other site 357808007464 ABC transporter signature motif; other site 357808007465 Walker B; other site 357808007466 D-loop; other site 357808007467 H-loop/switch region; other site 357808007468 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 357808007469 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 357808007470 homodimer interface [polypeptide binding]; other site 357808007471 substrate-cofactor binding pocket; other site 357808007472 catalytic residue [active] 357808007473 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 357808007474 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 357808007475 dimer interface [polypeptide binding]; other site 357808007476 active site 357808007477 WYL domain; Region: WYL; pfam13280 357808007478 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808007479 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 357808007480 putative ADP-binding pocket [chemical binding]; other site 357808007481 hypothetical protein; Provisional; Region: PRK06446 357808007482 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 357808007483 metal binding site [ion binding]; metal-binding site 357808007484 dimer interface [polypeptide binding]; other site 357808007485 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 357808007486 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 357808007487 active site 357808007488 Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Ade5; cd01416 357808007489 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 357808007490 ATP binding site [chemical binding]; other site 357808007491 active site 357808007492 substrate binding site [chemical binding]; other site 357808007493 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808007494 putative active site [active] 357808007495 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 357808007496 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 357808007497 dimerization interface [polypeptide binding]; other site 357808007498 putative ATP binding site [chemical binding]; other site 357808007499 Acylphosphatase; Region: Acylphosphatase; pfam00708 357808007500 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 357808007501 HypF finger; Region: zf-HYPF; pfam07503 357808007502 HypF finger; Region: zf-HYPF; pfam07503 357808007503 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 357808007504 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 357808007505 active site 357808007506 substrate binding pocket [chemical binding]; other site 357808007507 dimer interface [polypeptide binding]; other site 357808007508 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808007509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808007510 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808007511 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357808007512 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357808007513 DNA binding site [nucleotide binding] 357808007514 domain linker motif; other site 357808007515 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 357808007516 putative dimerization interface [polypeptide binding]; other site 357808007517 putative ligand binding site [chemical binding]; other site 357808007518 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 357808007519 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 357808007520 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 357808007521 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 357808007522 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 357808007523 PQQ-like domain; Region: PQQ_2; pfam13360 357808007524 Domain of unknown function (DUF427); Region: DUF427; pfam04248 357808007525 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 357808007526 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808007527 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808007528 active site 357808007529 NTP binding site [chemical binding]; other site 357808007530 metal binding triad [ion binding]; metal-binding site 357808007531 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 357808007532 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 357808007533 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 357808007534 tetramer interface [polypeptide binding]; other site 357808007535 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 357808007536 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 357808007537 tetramer interface [polypeptide binding]; other site 357808007538 active site 357808007539 metal binding site [ion binding]; metal-binding site 357808007540 Transcriptional regulator [Transcription]; Region: IclR; COG1414 357808007541 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 357808007542 Bacterial transcriptional regulator; Region: IclR; pfam01614 357808007543 acetaldehyde dehydrogenase; Validated; Region: PRK08300 357808007544 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 357808007545 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 357808007546 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 357808007547 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 357808007548 active site 357808007549 catalytic residues [active] 357808007550 metal binding site [ion binding]; metal-binding site 357808007551 DmpG-like communication domain; Region: DmpG_comm; pfam07836 357808007552 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 357808007553 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 357808007554 active site 1 [active] 357808007555 dimer interface [polypeptide binding]; other site 357808007556 hexamer interface [polypeptide binding]; other site 357808007557 active site 2 [active] 357808007558 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 357808007559 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357808007560 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 357808007561 NAD binding site [chemical binding]; other site 357808007562 catalytic residues [active] 357808007563 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 357808007564 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 357808007565 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 357808007566 intracellular protease, PfpI family; Region: PfpI; TIGR01382 357808007567 proposed catalytic triad [active] 357808007568 conserved cys residue [active] 357808007569 Bacterial transcriptional activator domain; Region: BTAD; smart01043 357808007570 Predicted ATPase [General function prediction only]; Region: COG3899 357808007571 AAA ATPase domain; Region: AAA_16; pfam13191 357808007572 TPR repeat; Region: TPR_11; pfam13414 357808007573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808007574 binding surface 357808007575 TPR motif; other site 357808007576 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808007577 CHAT domain; Region: CHAT; pfam12770 357808007578 AAA ATPase domain; Region: AAA_16; pfam13191 357808007579 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808007580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808007581 binding surface 357808007582 TPR motif; other site 357808007583 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808007584 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808007585 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808007586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808007587 binding surface 357808007588 TPR motif; other site 357808007589 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808007590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808007591 binding surface 357808007592 TPR motif; other site 357808007593 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808007594 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808007595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808007596 binding surface 357808007597 TPR motif; other site 357808007598 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808007599 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357808007600 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357808007601 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357808007602 FtsX-like permease family; Region: FtsX; pfam02687 357808007603 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 357808007604 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 357808007605 active site 357808007606 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 357808007607 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701 357808007608 CRISPR-associated protein, Csx11 family; Region: cas_csx11; TIGR02682 357808007609 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 357808007610 AAA domain; Region: AAA_21; pfam13304 357808007611 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 357808007612 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 357808007613 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808007614 putative active site [active] 357808007615 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 357808007616 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 357808007617 N- and C-terminal domain interface [polypeptide binding]; other site 357808007618 active site 357808007619 MgATP binding site [chemical binding]; other site 357808007620 catalytic site [active] 357808007621 metal binding site [ion binding]; metal-binding site 357808007622 xylulose binding site [chemical binding]; other site 357808007623 putative homodimer interface [polypeptide binding]; other site 357808007624 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357808007625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357808007626 catalytic residue [active] 357808007627 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 357808007628 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808007629 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808007630 active site 357808007631 ATP binding site [chemical binding]; other site 357808007632 substrate binding site [chemical binding]; other site 357808007633 activation loop (A-loop); other site 357808007634 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 357808007635 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 357808007636 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 357808007637 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 357808007638 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 357808007639 protein binding site [polypeptide binding]; other site 357808007640 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 357808007641 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 357808007642 Sporulation and spore germination; Region: Germane; pfam10646 357808007643 Sporulation and spore germination; Region: Germane; pfam10646 357808007644 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 357808007645 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357808007646 active site 357808007647 metal binding site [ion binding]; metal-binding site 357808007648 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 357808007649 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357808007650 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357808007651 catalytic residue [active] 357808007652 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 357808007653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808007654 S-adenosylmethionine binding site [chemical binding]; other site 357808007655 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 357808007656 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 357808007657 active site 357808007658 (T/H)XGH motif; other site 357808007659 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 357808007660 Ribosomal L32p protein family; Region: Ribosomal_L32p; pfam01783 357808007661 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 357808007662 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 357808007663 dimer interface [polypeptide binding]; other site 357808007664 active site 357808007665 CoA binding pocket [chemical binding]; other site 357808007666 carboxylate-amine ligase; Provisional; Region: PRK13515 357808007667 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 357808007668 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; pfam14403 357808007669 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357808007670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 357808007671 Putative esterase; Region: Esterase; pfam00756 357808007672 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 357808007673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808007674 S-adenosylmethionine binding site [chemical binding]; other site 357808007675 Protein of unknown function (DUF1444); Region: DUF1444; pfam07285 357808007676 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 357808007677 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 357808007678 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 357808007679 dimerization interface [polypeptide binding]; other site 357808007680 ATP binding site [chemical binding]; other site 357808007681 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 357808007682 dimerization interface [polypeptide binding]; other site 357808007683 ATP binding site [chemical binding]; other site 357808007684 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 357808007685 classical (c) SDRs; Region: SDR_c; cd05233 357808007686 NAD(P) binding site [chemical binding]; other site 357808007687 active site 357808007688 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 357808007689 Peptidase family M50; Region: Peptidase_M50; pfam02163 357808007690 active site 357808007691 putative substrate binding region [chemical binding]; other site 357808007692 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357808007693 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357808007694 ligand binding site [chemical binding]; other site 357808007695 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357808007696 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357808007697 ligand binding site [chemical binding]; other site 357808007698 flexible hinge region; other site 357808007699 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808007700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808007701 active site 357808007702 phosphorylation site [posttranslational modification] 357808007703 intermolecular recognition site; other site 357808007704 dimerization interface [polypeptide binding]; other site 357808007705 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808007706 DNA binding site [nucleotide binding] 357808007707 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808007708 dimerization interface [polypeptide binding]; other site 357808007709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808007710 dimer interface [polypeptide binding]; other site 357808007711 phosphorylation site [posttranslational modification] 357808007712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808007713 ATP binding site [chemical binding]; other site 357808007714 Mg2+ binding site [ion binding]; other site 357808007715 G-X-G motif; other site 357808007716 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357808007717 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357808007718 ligand binding site [chemical binding]; other site 357808007719 flexible hinge region; other site 357808007720 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 357808007721 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 357808007722 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 357808007723 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808007724 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808007725 active site 357808007726 ATP binding site [chemical binding]; other site 357808007727 substrate binding site [chemical binding]; other site 357808007728 activation loop (A-loop); other site 357808007729 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 357808007730 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 357808007731 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 357808007732 RNase_H superfamily; Region: RNase_H_2; pfam13482 357808007733 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 357808007734 active site 357808007735 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808007736 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 357808007737 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 357808007738 NADP binding site [chemical binding]; other site 357808007739 dimer interface [polypeptide binding]; other site 357808007740 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 357808007741 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 357808007742 putative ADP-binding pocket [chemical binding]; other site 357808007743 Beta-lactamase; Region: Beta-lactamase; pfam00144 357808007744 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357808007745 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 357808007746 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 357808007747 active site 357808007748 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808007749 putative active site [active] 357808007750 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 357808007751 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 357808007752 N-acetyl-D-glucosamine binding site [chemical binding]; other site 357808007753 catalytic residue [active] 357808007754 Protein of unknown function (DUF507); Region: DUF507; cl01112 357808007755 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 357808007756 lycopene cyclase; Region: lycopene_cycl; TIGR01789 357808007757 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 357808007758 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 357808007759 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 357808007760 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 357808007761 phosphate binding site [ion binding]; other site 357808007762 putative substrate binding pocket [chemical binding]; other site 357808007763 dimer interface [polypeptide binding]; other site 357808007764 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808007765 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 357808007766 substrate binding pocket [chemical binding]; other site 357808007767 substrate-Mg2+ binding site; other site 357808007768 aspartate-rich region 1; other site 357808007769 aspartate-rich region 2; other site 357808007770 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 357808007771 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 357808007772 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 357808007773 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 357808007774 phosphate binding site [ion binding]; other site 357808007775 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 357808007776 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 357808007777 active site 357808007778 substrate binding site [chemical binding]; other site 357808007779 metal binding site [ion binding]; metal-binding site 357808007780 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 357808007781 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 357808007782 active site 357808007783 substrate binding site [chemical binding]; other site 357808007784 metal binding site [ion binding]; metal-binding site 357808007785 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 357808007786 O-Antigen ligase; Region: Wzy_C; pfam04932 357808007787 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 357808007788 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357808007789 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808007790 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 357808007791 putative active site [active] 357808007792 heme pocket [chemical binding]; other site 357808007793 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 357808007794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808007795 putative active site [active] 357808007796 heme pocket [chemical binding]; other site 357808007797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808007798 ATP binding site [chemical binding]; other site 357808007799 Mg2+ binding site [ion binding]; other site 357808007800 G-X-G motif; other site 357808007801 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357808007802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808007803 active site 357808007804 phosphorylation site [posttranslational modification] 357808007805 intermolecular recognition site; other site 357808007806 dimerization interface [polypeptide binding]; other site 357808007807 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 357808007808 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 357808007809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808007810 TPR repeat; Region: TPR_11; pfam13414 357808007811 TPR motif; other site 357808007812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808007813 TPR motif; other site 357808007814 binding surface 357808007815 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 357808007816 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 357808007817 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 357808007818 cyclase homology domain; Region: CHD; cd07302 357808007819 nucleotidyl binding site; other site 357808007820 metal binding site [ion binding]; metal-binding site 357808007821 dimer interface [polypeptide binding]; other site 357808007822 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 357808007823 cyclase homology domain; Region: CHD; cd07302 357808007824 nucleotidyl binding site; other site 357808007825 metal binding site [ion binding]; metal-binding site 357808007826 dimer interface [polypeptide binding]; other site 357808007827 Predicted ATPase [General function prediction only]; Region: COG3899 357808007828 AAA ATPase domain; Region: AAA_16; pfam13191 357808007829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808007830 TPR motif; other site 357808007831 TPR repeat; Region: TPR_11; pfam13414 357808007832 binding surface 357808007833 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808007834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808007835 TPR motif; other site 357808007836 binding surface 357808007837 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808007838 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357808007839 putative DNA binding site [nucleotide binding]; other site 357808007840 dimerization interface [polypeptide binding]; other site 357808007841 putative Zn2+ binding site [ion binding]; other site 357808007842 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357808007843 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357808007844 Walker A/P-loop; other site 357808007845 ATP binding site [chemical binding]; other site 357808007846 Q-loop/lid; other site 357808007847 ABC transporter signature motif; other site 357808007848 Walker B; other site 357808007849 D-loop; other site 357808007850 H-loop/switch region; other site 357808007851 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 357808007852 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357808007853 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 357808007854 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 357808007855 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 357808007856 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 357808007857 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808007858 Methyltransferase domain; Region: Methyltransf_12; pfam08242 357808007859 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808007860 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808007861 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 357808007862 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357808007863 Probable Catalytic site; other site 357808007864 metal-binding site 357808007865 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808007866 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808007867 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808007868 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808007869 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 357808007870 active site 357808007871 metal binding site [ion binding]; metal-binding site 357808007872 homotetramer interface [polypeptide binding]; other site 357808007873 NAD synthetase; Reviewed; Region: nadE; PRK02628 357808007874 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 357808007875 multimer interface [polypeptide binding]; other site 357808007876 active site 357808007877 catalytic triad [active] 357808007878 protein interface 1 [polypeptide binding]; other site 357808007879 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 357808007880 homodimer interface [polypeptide binding]; other site 357808007881 NAD binding pocket [chemical binding]; other site 357808007882 ATP binding pocket [chemical binding]; other site 357808007883 Mg binding site [ion binding]; other site 357808007884 active-site loop [active] 357808007885 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808007886 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808007887 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808007888 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808007889 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808007890 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808007891 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 357808007892 YhhN-like protein; Region: YhhN; pfam07947 357808007893 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 357808007894 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 357808007895 Protein of unknown function DUF45; Region: DUF45; cl00636 357808007896 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 357808007897 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 357808007898 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808007899 ATP binding site [chemical binding]; other site 357808007900 putative Mg++ binding site [ion binding]; other site 357808007901 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 357808007902 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 357808007903 HsdM N-terminal domain; Region: HsdM_N; pfam12161 357808007904 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 357808007905 Methyltransferase domain; Region: Methyltransf_26; pfam13659 357808007906 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 357808007907 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 357808007908 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 357808007909 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 357808007910 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 357808007911 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 357808007912 active site 357808007913 substrate binding site [chemical binding]; other site 357808007914 cosubstrate binding site; other site 357808007915 catalytic site [active] 357808007916 Response regulator receiver domain; Region: Response_reg; pfam00072 357808007917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808007918 active site 357808007919 phosphorylation site [posttranslational modification] 357808007920 intermolecular recognition site; other site 357808007921 dimerization interface [polypeptide binding]; other site 357808007922 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808007923 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808007924 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808007925 GAF domain; Region: GAF_3; pfam13492 357808007926 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808007927 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808007928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808007929 PAS domain; Region: PAS_9; pfam13426 357808007930 putative active site [active] 357808007931 heme pocket [chemical binding]; other site 357808007932 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 357808007933 cyclase homology domain; Region: CHD; cd07302 357808007934 nucleotidyl binding site; other site 357808007935 metal binding site [ion binding]; metal-binding site 357808007936 dimer interface [polypeptide binding]; other site 357808007937 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 357808007938 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 357808007939 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 357808007940 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 357808007941 Predicted transcriptional regulator [Transcription]; Region: COG2378 357808007942 HTH domain; Region: HTH_11; pfam08279 357808007943 WYL domain; Region: WYL; pfam13280 357808007944 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 357808007945 AAA domain; Region: AAA_27; pfam13514 357808007946 Protein of unknown function DUF58; Region: DUF58; pfam01882 357808007947 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 357808007948 metal ion-dependent adhesion site (MIDAS); other site 357808007949 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 357808007950 metal ion-dependent adhesion site (MIDAS); other site 357808007951 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 357808007952 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 357808007953 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 357808007954 metal ion-dependent adhesion site (MIDAS); other site 357808007955 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 357808007956 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 357808007957 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 357808007958 putative acyl-acceptor binding pocket; other site 357808007959 Protein of unknown function (DUF422); Region: DUF422; cl00991 357808007960 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 357808007961 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 357808007962 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 357808007963 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 357808007964 Response regulator receiver domain; Region: Response_reg; pfam00072 357808007965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808007966 active site 357808007967 phosphorylation site [posttranslational modification] 357808007968 intermolecular recognition site; other site 357808007969 dimerization interface [polypeptide binding]; other site 357808007970 Predicted permease [General function prediction only]; Region: COG2985 357808007971 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 357808007972 TrkA-C domain; Region: TrkA_C; pfam02080 357808007973 TrkA-C domain; Region: TrkA_C; pfam02080 357808007974 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 357808007975 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 357808007976 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 357808007977 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 357808007978 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 357808007979 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 357808007980 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 357808007981 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 357808007982 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 357808007983 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 357808007984 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808007985 dimerization interface [polypeptide binding]; other site 357808007986 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808007987 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357808007988 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357808007989 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 357808007990 Walker A/P-loop; other site 357808007991 ATP binding site [chemical binding]; other site 357808007992 Q-loop/lid; other site 357808007993 ABC transporter signature motif; other site 357808007994 Walker B; other site 357808007995 D-loop; other site 357808007996 H-loop/switch region; other site 357808007997 Domain of unknown function (DUF385); Region: DUF385; pfam04075 357808007998 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357808007999 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357808008000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357808008001 Walker A/P-loop; other site 357808008002 ATP binding site [chemical binding]; other site 357808008003 Q-loop/lid; other site 357808008004 ABC transporter signature motif; other site 357808008005 Walker B; other site 357808008006 D-loop; other site 357808008007 H-loop/switch region; other site 357808008008 MarR family; Region: MarR; pfam01047 357808008009 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 357808008010 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 357808008011 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357808008012 inhibitor-cofactor binding pocket; inhibition site 357808008013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808008014 catalytic residue [active] 357808008015 acetyl-lysine deacetylase; Provisional; Region: PRK04443 357808008016 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 357808008017 metal binding site [ion binding]; metal-binding site 357808008018 putative dimer interface [polypeptide binding]; other site 357808008019 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 357808008020 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 357808008021 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 357808008022 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357808008023 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357808008024 Walker A/P-loop; other site 357808008025 ATP binding site [chemical binding]; other site 357808008026 Q-loop/lid; other site 357808008027 ABC transporter signature motif; other site 357808008028 Walker B; other site 357808008029 D-loop; other site 357808008030 H-loop/switch region; other site 357808008031 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357808008032 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357808008033 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357808008034 TM-ABC transporter signature motif; other site 357808008035 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357808008036 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357808008037 TM-ABC transporter signature motif; other site 357808008038 Domain of unknown function (DUF718); Region: DUF718; pfam05336 357808008039 L-rhamnose isomerase; Provisional; Region: PRK01076 357808008040 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 357808008041 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632 357808008042 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 357808008043 active site 357808008044 Zn2+ binding site [ion binding]; other site 357808008045 intersubunit interface [polypeptide binding]; other site 357808008046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808008047 NAD(P) binding site [chemical binding]; other site 357808008048 active site 357808008049 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 357808008050 N- and C-terminal domain interface [polypeptide binding]; other site 357808008051 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 357808008052 active site 357808008053 putative catalytic site [active] 357808008054 metal binding site [ion binding]; metal-binding site 357808008055 ATP binding site [chemical binding]; other site 357808008056 carbohydrate binding site [chemical binding]; other site 357808008057 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 357808008058 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 357808008059 putative substrate-binding site; other site 357808008060 nickel binding site [ion binding]; other site 357808008061 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 357808008062 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 357808008063 active site 357808008064 ADP/pyrophosphate binding site [chemical binding]; other site 357808008065 dimerization interface [polypeptide binding]; other site 357808008066 allosteric effector site; other site 357808008067 fructose-1,6-bisphosphate binding site; other site 357808008068 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 357808008069 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 357808008070 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 357808008071 Putative glucoamylase; Region: Glycoamylase; pfam10091 357808008072 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 357808008073 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 357808008074 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 357808008075 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357808008076 Protease prsW family; Region: PrsW-protease; pfam13367 357808008077 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808008078 putative active site [active] 357808008079 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 357808008080 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 357808008081 putative active site; other site 357808008082 catalytic triad [active] 357808008083 putative dimer interface [polypeptide binding]; other site 357808008084 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 357808008085 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 357808008086 Integral membrane protein DUF92; Region: DUF92; pfam01940 357808008087 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 357808008088 hydrophobic ligand binding site; other site 357808008089 Aspartyl protease; Region: Asp_protease_2; pfam13650 357808008090 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 357808008091 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 357808008092 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 357808008093 TPR repeat; Region: TPR_11; pfam13414 357808008094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808008095 binding surface 357808008096 TPR motif; other site 357808008097 TPR repeat; Region: TPR_11; pfam13414 357808008098 TPR repeat; Region: TPR_11; pfam13414 357808008099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808008100 binding surface 357808008101 TPR motif; other site 357808008102 TPR repeat; Region: TPR_11; pfam13414 357808008103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808008104 binding surface 357808008105 TPR motif; other site 357808008106 TPR repeat; Region: TPR_11; pfam13414 357808008107 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357808008108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808008109 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 357808008110 putative substrate translocation pore; other site 357808008111 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 357808008112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808008113 active site 357808008114 motif I; other site 357808008115 motif II; other site 357808008116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808008117 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 357808008118 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 357808008119 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 357808008120 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 357808008121 VanW like protein; Region: VanW; pfam04294 357808008122 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 357808008123 Active_site [active] 357808008124 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 357808008125 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 357808008126 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 357808008127 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 357808008128 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 357808008129 NMT1/THI5 like; Region: NMT1; pfam09084 357808008130 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 357808008131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808008132 putative PBP binding loops; other site 357808008133 ABC-ATPase subunit interface; other site 357808008134 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 357808008135 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 357808008136 nucleotide binding site [chemical binding]; other site 357808008137 Double zinc ribbon; Region: DZR; pfam12773 357808008138 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808008139 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 357808008140 active site 357808008141 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808008142 Double zinc ribbon; Region: DZR; pfam12773 357808008143 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 357808008144 Protein phosphatase 2C; Region: PP2C; pfam00481 357808008145 active site 357808008146 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808008147 Double zinc ribbon; Region: DZR; pfam12773 357808008148 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808008149 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808008150 active site 357808008151 ATP binding site [chemical binding]; other site 357808008152 substrate binding site [chemical binding]; other site 357808008153 activation loop (A-loop); other site 357808008154 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 357808008155 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 357808008156 metal ion-dependent adhesion site (MIDAS); other site 357808008157 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808008158 Double zinc ribbon; Region: DZR; pfam12773 357808008159 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808008160 Double zinc ribbon; Region: DZR; pfam12773 357808008161 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808008162 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808008163 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808008164 phosphopeptide binding site; other site 357808008165 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 357808008166 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 357808008167 peptide binding site [polypeptide binding]; other site 357808008168 dimer interface [polypeptide binding]; other site 357808008169 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 357808008170 Na binding site [ion binding]; other site 357808008171 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 357808008172 hypothetical protein; Provisional; Region: PRK02399 357808008173 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 357808008174 YtkA-like; Region: YtkA; pfam13115 357808008175 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357808008176 Beta-lactamase; Region: Beta-lactamase; pfam00144 357808008177 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 357808008178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808008179 Walker A motif; other site 357808008180 ATP binding site [chemical binding]; other site 357808008181 Walker B motif; other site 357808008182 arginine finger; other site 357808008183 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 357808008184 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 357808008185 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 357808008186 putative dimer interface [polypeptide binding]; other site 357808008187 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 357808008188 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 357808008189 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 357808008190 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 357808008191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808008192 S-adenosylmethionine binding site [chemical binding]; other site 357808008193 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 357808008194 RNA/DNA hybrid binding site [nucleotide binding]; other site 357808008195 active site 357808008196 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 357808008197 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 357808008198 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 357808008199 Winged helix-turn helix; Region: HTH_29; pfam13551 357808008200 Homeodomain-like domain; Region: HTH_32; pfam13565 357808008201 Winged helix-turn helix; Region: HTH_33; pfam13592 357808008202 DDE superfamily endonuclease; Region: DDE_3; pfam13358 357808008203 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 357808008204 substrate binding site [chemical binding]; other site 357808008205 ATP binding site [chemical binding]; other site 357808008206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808008207 S-adenosylmethionine binding site [chemical binding]; other site 357808008208 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808008209 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 357808008210 Putative zinc-finger; Region: zf-HC2; pfam13490 357808008211 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 357808008212 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808008213 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808008214 DNA binding residues [nucleotide binding] 357808008215 Putative zinc-finger; Region: zf-HC2; pfam13490 357808008216 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 357808008217 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357808008218 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 357808008219 metal ion-dependent adhesion site (MIDAS); other site 357808008220 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808008221 putative active site [active] 357808008222 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 357808008223 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 357808008224 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357808008225 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 357808008226 metal ion-dependent adhesion site (MIDAS); other site 357808008227 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 357808008228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357808008229 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 357808008230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808008231 S-adenosylmethionine binding site [chemical binding]; other site 357808008232 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 357808008233 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 357808008234 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 357808008235 Pleckstrin homology-like domain; Region: PH-like; cl17171 357808008236 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 357808008237 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 357808008238 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 357808008239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808008240 dimer interface [polypeptide binding]; other site 357808008241 conserved gate region; other site 357808008242 putative PBP binding loops; other site 357808008243 ABC-ATPase subunit interface; other site 357808008244 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 357808008245 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 357808008246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808008247 dimer interface [polypeptide binding]; other site 357808008248 conserved gate region; other site 357808008249 putative PBP binding loops; other site 357808008250 ABC-ATPase subunit interface; other site 357808008251 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 357808008252 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357808008253 Walker A/P-loop; other site 357808008254 ATP binding site [chemical binding]; other site 357808008255 Q-loop/lid; other site 357808008256 ABC transporter signature motif; other site 357808008257 Walker B; other site 357808008258 D-loop; other site 357808008259 H-loop/switch region; other site 357808008260 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357808008261 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 357808008262 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357808008263 Walker A/P-loop; other site 357808008264 ATP binding site [chemical binding]; other site 357808008265 Q-loop/lid; other site 357808008266 ABC transporter signature motif; other site 357808008267 Walker B; other site 357808008268 D-loop; other site 357808008269 H-loop/switch region; other site 357808008270 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 357808008271 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 357808008272 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 357808008273 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 357808008274 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 357808008275 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 357808008276 putative active site pocket [active] 357808008277 metal binding site [ion binding]; metal-binding site 357808008278 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 357808008279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357808008280 DNA-binding site [nucleotide binding]; DNA binding site 357808008281 FCD domain; Region: FCD; pfam07729 357808008282 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357808008283 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357808008284 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357808008285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808008286 dimer interface [polypeptide binding]; other site 357808008287 conserved gate region; other site 357808008288 putative PBP binding loops; other site 357808008289 ABC-ATPase subunit interface; other site 357808008290 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357808008291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808008292 dimer interface [polypeptide binding]; other site 357808008293 putative PBP binding loops; other site 357808008294 ABC-ATPase subunit interface; other site 357808008295 ParB-like nuclease domain; Region: ParBc; pfam02195 357808008296 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 357808008297 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808008298 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808008299 phosphopeptide binding site; other site 357808008300 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 357808008301 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 357808008302 metal ion-dependent adhesion site (MIDAS); other site 357808008303 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357808008304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357808008305 TAP-like protein; Region: Abhydrolase_4; pfam08386 357808008306 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 357808008307 active site 357808008308 catalytic residues [active] 357808008309 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 357808008310 generic binding surface I; other site 357808008311 generic binding surface II; other site 357808008312 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 357808008313 putative active site [active] 357808008314 putative catalytic site [active] 357808008315 putative Mg binding site IVb [ion binding]; other site 357808008316 putative phosphate binding site [ion binding]; other site 357808008317 putative DNA binding site [nucleotide binding]; other site 357808008318 putative Mg binding site IVa [ion binding]; other site 357808008319 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 357808008320 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 357808008321 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 357808008322 active site 357808008323 catalytic triad [active] 357808008324 Cna protein B-type domain; Region: Cna_B_2; pfam13715 357808008325 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 357808008326 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 357808008327 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 357808008328 putative acyl-acceptor binding pocket; other site 357808008329 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808008330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808008331 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808008332 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 357808008333 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 357808008334 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 357808008335 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 357808008336 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 357808008337 dimer interface [polypeptide binding]; other site 357808008338 active site 357808008339 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357808008340 catalytic residues [active] 357808008341 substrate binding site [chemical binding]; other site 357808008342 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808008343 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808008344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808008345 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 357808008346 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808008347 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808008348 pinin/SDK/memA/ protein conserved region; Region: Pinin_SDK_memA; pfam04696 357808008349 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808008350 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808008351 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808008352 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808008353 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357808008354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357808008355 metal binding site [ion binding]; metal-binding site 357808008356 active site 357808008357 I-site; other site 357808008358 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808008359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808008360 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808008361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808008362 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808008363 putative active site [active] 357808008364 heme pocket [chemical binding]; other site 357808008365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808008366 dimer interface [polypeptide binding]; other site 357808008367 phosphorylation site [posttranslational modification] 357808008368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808008369 ATP binding site [chemical binding]; other site 357808008370 Mg2+ binding site [ion binding]; other site 357808008371 G-X-G motif; other site 357808008372 Response regulator receiver domain; Region: Response_reg; pfam00072 357808008373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808008374 active site 357808008375 phosphorylation site [posttranslational modification] 357808008376 intermolecular recognition site; other site 357808008377 dimerization interface [polypeptide binding]; other site 357808008378 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 357808008379 DNA protecting protein DprA; Region: dprA; TIGR00732 357808008380 DHH family; Region: DHH; pfam01368 357808008381 FOG: CBS domain [General function prediction only]; Region: COG0517 357808008382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 357808008383 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 357808008384 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 357808008385 active site 357808008386 NTP binding site [chemical binding]; other site 357808008387 metal binding triad [ion binding]; metal-binding site 357808008388 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 357808008389 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808008390 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808008391 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808008392 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357808008393 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357808008394 active site 357808008395 PAS fold; Region: PAS_4; pfam08448 357808008396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808008397 putative active site [active] 357808008398 heme pocket [chemical binding]; other site 357808008399 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808008400 Transposase [DNA replication, recombination, and repair]; Region: COG5421 357808008401 Transposase [DNA replication, recombination, and repair]; Region: COG5421 357808008402 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 357808008403 Protein of unknown function (DUF993); Region: DUF993; pfam06187 357808008404 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808008405 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808008406 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808008407 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357808008408 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357808008409 DNA binding site [nucleotide binding] 357808008410 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357808008411 dimerization interface [polypeptide binding]; other site 357808008412 ligand binding site [chemical binding]; other site 357808008413 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357808008414 Uncharacterized conserved protein [Function unknown]; Region: COG3375 357808008415 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 357808008416 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 357808008417 active site 357808008418 octamer interface [polypeptide binding]; other site 357808008419 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 357808008420 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 357808008421 quinone interaction residues [chemical binding]; other site 357808008422 active site 357808008423 catalytic residues [active] 357808008424 FMN binding site [chemical binding]; other site 357808008425 substrate binding site [chemical binding]; other site 357808008426 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 357808008427 FAD binding pocket [chemical binding]; other site 357808008428 FAD binding motif [chemical binding]; other site 357808008429 phosphate binding motif [ion binding]; other site 357808008430 beta-alpha-beta structure motif; other site 357808008431 NAD binding pocket [chemical binding]; other site 357808008432 Iron coordination center [ion binding]; other site 357808008433 dihydroorotase; Validated; Region: pyrC; PRK09357 357808008434 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357808008435 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 357808008436 active site 357808008437 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 357808008438 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 357808008439 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 357808008440 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 357808008441 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357808008442 active site 357808008443 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 357808008444 hydrophobic ligand binding site; other site 357808008445 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 357808008446 catalytic center binding site [active] 357808008447 ATP binding site [chemical binding]; other site 357808008448 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 357808008449 adenosine deaminase; Provisional; Region: PRK09358 357808008450 active site 357808008451 peptide chain release factor 1; Validated; Region: prfA; PRK00591 357808008452 This domain is found in peptide chain release factors; Region: PCRF; smart00937 357808008453 RF-1 domain; Region: RF-1; pfam00472 357808008454 Bacterial Ig-like domain; Region: Big_5; pfam13205 357808008455 Bacterial Ig-like domain; Region: Big_5; pfam13205 357808008456 Bacterial Ig-like domain; Region: Big_5; pfam13205 357808008457 Bacterial Ig-like domain; Region: Big_5; pfam13205 357808008458 Bacterial Ig-like domain; Region: Big_5; pfam13205 357808008459 Bacterial Ig-like domain; Region: Big_5; pfam13205 357808008460 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 357808008461 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 357808008462 MG2 domain; Region: A2M_N; pfam01835 357808008463 Alpha-2-macroglobulin family; Region: A2M; pfam00207 357808008464 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 357808008465 surface patch; other site 357808008466 thioester region; other site 357808008467 specificity defining residues; other site 357808008468 Transglycosylase; Region: Transgly; pfam00912 357808008469 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 357808008470 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357808008471 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 357808008472 putative phosphoesterase; Region: acc_ester; TIGR03729 357808008473 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357808008474 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 357808008475 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 357808008476 Flagellin N-methylase; Region: FliB; cl00497 357808008477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808008478 TPR motif; other site 357808008479 TPR repeat; Region: TPR_11; pfam13414 357808008480 binding surface 357808008481 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 357808008482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808008483 putative substrate translocation pore; other site 357808008484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808008485 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 357808008486 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357808008487 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 357808008488 dimer interface [polypeptide binding]; other site 357808008489 putative metal binding site [ion binding]; other site 357808008490 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808008491 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808008492 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808008493 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 357808008494 mannonate dehydratase; Region: uxuA; TIGR00695 357808008495 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 357808008496 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 357808008497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808008498 NAD(P) binding site [chemical binding]; other site 357808008499 active site 357808008500 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 357808008501 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 357808008502 xylose isomerase; Provisional; Region: PRK12677 357808008503 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 357808008504 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 357808008505 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 357808008506 N- and C-terminal domain interface [polypeptide binding]; other site 357808008507 D-xylulose kinase; Region: XylB; TIGR01312 357808008508 active site 357808008509 MgATP binding site [chemical binding]; other site 357808008510 catalytic site [active] 357808008511 metal binding site [ion binding]; metal-binding site 357808008512 xylulose binding site [chemical binding]; other site 357808008513 homodimer interface [polypeptide binding]; other site 357808008514 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 357808008515 VanW like protein; Region: VanW; pfam04294 357808008516 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 357808008517 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 357808008518 dimer interface [polypeptide binding]; other site 357808008519 active site 357808008520 alpha-galactosidase; Provisional; Region: PRK15076 357808008521 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 357808008522 NAD binding site [chemical binding]; other site 357808008523 sugar binding site [chemical binding]; other site 357808008524 divalent metal binding site [ion binding]; other site 357808008525 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 357808008526 dimer interface [polypeptide binding]; other site 357808008527 Family description; Region: VCBS; pfam13517 357808008528 Family description; Region: VCBS; pfam13517 357808008529 Family description; Region: VCBS; pfam13517 357808008530 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 357808008531 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357808008532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808008533 dimer interface [polypeptide binding]; other site 357808008534 conserved gate region; other site 357808008535 putative PBP binding loops; other site 357808008536 ABC-ATPase subunit interface; other site 357808008537 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357808008538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808008539 dimer interface [polypeptide binding]; other site 357808008540 conserved gate region; other site 357808008541 putative PBP binding loops; other site 357808008542 ABC-ATPase subunit interface; other site 357808008543 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357808008544 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357808008545 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 357808008546 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357808008547 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357808008548 active site 357808008549 metal binding site [ion binding]; metal-binding site 357808008550 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 357808008551 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808008552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808008553 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808008554 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357808008555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 357808008556 intermolecular recognition site; other site 357808008557 active site 357808008558 dimerization interface [polypeptide binding]; other site 357808008559 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357808008560 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357808008561 active site 357808008562 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 357808008563 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357808008564 active site 357808008565 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 357808008566 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 357808008567 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 357808008568 active site 357808008569 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 357808008570 putative NADP binding site [chemical binding]; other site 357808008571 active site 357808008572 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 357808008573 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 357808008574 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 357808008575 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 357808008576 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 357808008577 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 357808008578 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 357808008579 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357808008580 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357808008581 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 357808008582 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 357808008583 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 357808008584 carboxyltransferase (CT) interaction site; other site 357808008585 biotinylation site [posttranslational modification]; other site 357808008586 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 357808008587 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357808008588 active site 357808008589 dimer interface [polypeptide binding]; other site 357808008590 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 357808008591 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 357808008592 Cu(I) binding site [ion binding]; other site 357808008593 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357808008594 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 357808008595 catalytic loop [active] 357808008596 iron binding site [ion binding]; other site 357808008597 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808008598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808008599 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808008600 four helix bundle protein; Region: TIGR02436 357808008601 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 357808008602 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 357808008603 Uncharacterized conserved protein [Function unknown]; Region: COG1262 357808008604 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808008605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808008606 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808008607 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 357808008608 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808008609 ATP binding site [chemical binding]; other site 357808008610 putative Mg++ binding site [ion binding]; other site 357808008611 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808008612 nucleotide binding region [chemical binding]; other site 357808008613 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 357808008614 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 357808008615 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 357808008616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808008617 motif II; other site 357808008618 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 357808008619 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 357808008620 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 357808008621 hydroxyglutarate oxidase; Provisional; Region: PRK11728 357808008622 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357808008623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808008624 Coenzyme A binding pocket [chemical binding]; other site 357808008625 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 357808008626 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 357808008627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808008628 putative substrate translocation pore; other site 357808008629 putative hydrolase; Provisional; Region: PRK11460 357808008630 Predicted esterase [General function prediction only]; Region: COG0400 357808008631 PemK-like protein; Region: PemK; pfam02452 357808008632 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808008633 active site 357808008634 NTP binding site [chemical binding]; other site 357808008635 metal binding triad [ion binding]; metal-binding site 357808008636 antibiotic binding site [chemical binding]; other site 357808008637 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808008638 putative active site [active] 357808008639 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808008640 putative active site [active] 357808008641 Methyltransferase domain; Region: Methyltransf_26; pfam13659 357808008642 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 357808008643 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357808008644 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808008645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808008646 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808008647 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 357808008648 Family description; Region: UvrD_C_2; pfam13538 357808008649 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 357808008650 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 357808008651 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 357808008652 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 357808008653 Bacterial sugar transferase; Region: Bac_transf; pfam02397 357808008654 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357808008655 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357808008656 Probable Catalytic site; other site 357808008657 metal-binding site 357808008658 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 357808008659 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 357808008660 substrate binding site [chemical binding]; other site 357808008661 active site 357808008662 catalytic residues [active] 357808008663 heterodimer interface [polypeptide binding]; other site 357808008664 alpha-ketoglutarate dehydrogenase; Region: AKGDH_not_PDH; TIGR03186 357808008665 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 357808008666 TPP-binding site [chemical binding]; other site 357808008667 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 357808008668 PYR/PP interface [polypeptide binding]; other site 357808008669 dimer interface [polypeptide binding]; other site 357808008670 TPP binding site [chemical binding]; other site 357808008671 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 357808008672 Protein of unknown function DUF86; Region: DUF86; pfam01934 357808008673 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808008674 active site 357808008675 NTP binding site [chemical binding]; other site 357808008676 metal binding triad [ion binding]; metal-binding site 357808008677 antibiotic binding site [chemical binding]; other site 357808008678 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 357808008679 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 357808008680 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 357808008681 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 357808008682 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 357808008683 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 357808008684 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 357808008685 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 357808008686 homotrimer interaction site [polypeptide binding]; other site 357808008687 putative active site [active] 357808008688 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 357808008689 active site residue [active] 357808008690 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 357808008691 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808008692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808008693 DNA binding residues [nucleotide binding] 357808008694 dimerization interface [polypeptide binding]; other site 357808008695 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 357808008696 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 357808008697 FMN binding site [chemical binding]; other site 357808008698 active site 357808008699 homodimer interface [polypeptide binding]; other site 357808008700 putative catalytic residue [active] 357808008701 4Fe-4S cluster binding site [ion binding]; other site 357808008702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357808008703 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 357808008704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808008705 S-adenosylmethionine binding site [chemical binding]; other site 357808008706 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 357808008707 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 357808008708 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 357808008709 beta-galactosidase; Region: BGL; TIGR03356 357808008710 Domain of unknown function DUF87; Region: DUF87; pfam01935 357808008711 AAA-like domain; Region: AAA_10; pfam12846 357808008712 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 357808008713 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 357808008714 dimer interface [polypeptide binding]; other site 357808008715 active site 357808008716 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 357808008717 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 357808008718 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 357808008719 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 357808008720 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357808008721 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 357808008722 substrate binding site [chemical binding]; other site 357808008723 oxyanion hole (OAH) forming residues; other site 357808008724 trimer interface [polypeptide binding]; other site 357808008725 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357808008726 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357808008727 active site 357808008728 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357808008729 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357808008730 active site 357808008731 SCP-2 sterol transfer family; Region: SCP2; pfam02036 357808008732 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 357808008733 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 357808008734 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 357808008735 dimerization interface [polypeptide binding]; other site 357808008736 ligand binding site [chemical binding]; other site 357808008737 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 357808008738 TM-ABC transporter signature motif; other site 357808008739 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 357808008740 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 357808008741 TM-ABC transporter signature motif; other site 357808008742 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 357808008743 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 357808008744 Walker A/P-loop; other site 357808008745 ATP binding site [chemical binding]; other site 357808008746 Q-loop/lid; other site 357808008747 ABC transporter signature motif; other site 357808008748 Walker B; other site 357808008749 D-loop; other site 357808008750 H-loop/switch region; other site 357808008751 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 357808008752 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 357808008753 Walker A/P-loop; other site 357808008754 ATP binding site [chemical binding]; other site 357808008755 Q-loop/lid; other site 357808008756 ABC transporter signature motif; other site 357808008757 Walker B; other site 357808008758 D-loop; other site 357808008759 H-loop/switch region; other site 357808008760 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 357808008761 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 357808008762 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357808008763 alanine racemase; Reviewed; Region: alr; PRK00053 357808008764 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 357808008765 active site 357808008766 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357808008767 dimer interface [polypeptide binding]; other site 357808008768 substrate binding site [chemical binding]; other site 357808008769 catalytic residues [active] 357808008770 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 357808008771 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 357808008772 active site 357808008773 glutamine synthetase, type I; Region: GlnA; TIGR00653 357808008774 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 357808008775 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 357808008776 ammonium transporter; Region: amt; TIGR00836 357808008777 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 357808008778 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 357808008779 active site 357808008780 dimer interface [polypeptide binding]; other site 357808008781 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 357808008782 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 357808008783 active site 357808008784 FMN binding site [chemical binding]; other site 357808008785 substrate binding site [chemical binding]; other site 357808008786 3Fe-4S cluster binding site [ion binding]; other site 357808008787 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 357808008788 domain interface; other site 357808008789 NHL repeat; Region: NHL; pfam01436 357808008790 FOG: WD40-like repeat [Function unknown]; Region: COG1520 357808008791 NHL repeat; Region: NHL; pfam01436 357808008792 NHL repeat; Region: NHL; pfam01436 357808008793 NHL repeat; Region: NHL; pfam01436 357808008794 NHL repeat; Region: NHL; pfam01436 357808008795 Uncharacterized conserved protein [Function unknown]; Region: COG3391 357808008796 NHL repeat; Region: NHL; pfam01436 357808008797 NHL repeat; Region: NHL; pfam01436 357808008798 NHL repeat; Region: NHL; pfam01436 357808008799 NHL repeat; Region: NHL; pfam01436 357808008800 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 357808008801 Domain of unknown function (DUF1973); Region: DUF1973; pfam09315 357808008802 homoserine dehydrogenase; Provisional; Region: PRK06270 357808008803 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 357808008804 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 357808008805 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357808008806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808008807 Coenzyme A binding pocket [chemical binding]; other site 357808008808 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 357808008809 NADH dehydrogenase subunit B; Provisional; Region: PRK14819 357808008810 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 357808008811 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 357808008812 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 357808008813 NADH dehydrogenase subunit D; Validated; Region: PRK06075 357808008814 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 357808008815 4Fe-4S binding domain; Region: Fer4; pfam00037 357808008816 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 357808008817 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 357808008818 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 357808008819 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 357808008820 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 357808008821 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 357808008822 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 357808008823 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 357808008824 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357808008825 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 357808008826 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 357808008827 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357808008828 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 357808008829 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357808008830 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 357808008831 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357808008832 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 357808008833 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 357808008834 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357808008835 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357808008836 short chain dehydrogenase; Provisional; Region: PRK08219 357808008837 Tthb094 and related proteins, classical (c) SDRs; Region: Tthb094_like_SDR_c; cd11730 357808008838 NAD(P) binding site [chemical binding]; other site 357808008839 putative active site [active] 357808008840 AAA domain; Region: AAA_32; pfam13654 357808008841 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 357808008842 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 357808008843 agmatinase; Region: agmatinase; TIGR01230 357808008844 oligomer interface [polypeptide binding]; other site 357808008845 putative active site [active] 357808008846 Mn binding site [ion binding]; other site 357808008847 Peptidase family M23; Region: Peptidase_M23; pfam01551 357808008848 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 357808008849 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 357808008850 metal ion-dependent adhesion site (MIDAS); other site 357808008851 WYL domain; Region: WYL; pfam13280 357808008852 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 357808008853 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 357808008854 Tandem repeat subunit of reelin and related proteins; Region: Reelin_subrepeat_like; cl15240 357808008855 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 357808008856 metal ion-dependent adhesion site (MIDAS); other site 357808008857 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 357808008858 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 357808008859 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 357808008860 putative NTP binding site [chemical binding]; other site 357808008861 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 357808008862 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 357808008863 putative nucleic acid binding site [nucleotide binding]; other site 357808008864 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 357808008865 RNA/DNA hybrid binding site [nucleotide binding]; other site 357808008866 active site 357808008867 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 357808008868 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 357808008869 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 357808008870 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 357808008871 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 357808008872 WYL domain; Region: WYL; pfam13280 357808008873 CRISPR-associated protein (Cas_Cas02710); Region: Cas_Cas02710; pfam09670 357808008874 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09747 357808008875 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 357808008876 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 357808008877 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 357808008878 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 357808008879 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357808008880 protein binding site [polypeptide binding]; other site 357808008881 Response regulator receiver domain; Region: Response_reg; pfam00072 357808008882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808008883 active site 357808008884 phosphorylation site [posttranslational modification] 357808008885 intermolecular recognition site; other site 357808008886 dimerization interface [polypeptide binding]; other site 357808008887 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808008888 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808008889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808008890 putative active site [active] 357808008891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808008892 heme pocket [chemical binding]; other site 357808008893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808008894 dimer interface [polypeptide binding]; other site 357808008895 phosphorylation site [posttranslational modification] 357808008896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808008897 ATP binding site [chemical binding]; other site 357808008898 Mg2+ binding site [ion binding]; other site 357808008899 G-X-G motif; other site 357808008900 Response regulator receiver domain; Region: Response_reg; pfam00072 357808008901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808008902 active site 357808008903 phosphorylation site [posttranslational modification] 357808008904 intermolecular recognition site; other site 357808008905 dimerization interface [polypeptide binding]; other site 357808008906 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: GCD2; COG1184 357808008907 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 357808008908 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 357808008909 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 357808008910 Peptidase family M23; Region: Peptidase_M23; pfam01551 357808008911 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 357808008912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 357808008913 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 357808008914 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 357808008915 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 357808008916 serine O-acetyltransferase; Region: cysE; TIGR01172 357808008917 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 357808008918 trimer interface [polypeptide binding]; other site 357808008919 active site 357808008920 substrate binding site [chemical binding]; other site 357808008921 CoA binding site [chemical binding]; other site 357808008922 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 357808008923 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 357808008924 active site 357808008925 HIGH motif; other site 357808008926 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 357808008927 KMSKS motif; other site 357808008928 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 357808008929 tRNA binding surface [nucleotide binding]; other site 357808008930 anticodon binding site; other site 357808008931 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 357808008932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357808008933 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 357808008934 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 357808008935 C-terminal peptidase (prc); Region: prc; TIGR00225 357808008936 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 357808008937 protein binding site [polypeptide binding]; other site 357808008938 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 357808008939 Catalytic dyad [active] 357808008940 HEPN domain; Region: HEPN; pfam05168 357808008941 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808008942 active site 357808008943 NTP binding site [chemical binding]; other site 357808008944 metal binding triad [ion binding]; metal-binding site 357808008945 antibiotic binding site [chemical binding]; other site 357808008946 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 357808008947 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 357808008948 putative active site [active] 357808008949 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 357808008950 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 357808008951 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 357808008952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808008953 dimer interface [polypeptide binding]; other site 357808008954 conserved gate region; other site 357808008955 putative PBP binding loops; other site 357808008956 ABC-ATPase subunit interface; other site 357808008957 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 357808008958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808008959 dimer interface [polypeptide binding]; other site 357808008960 conserved gate region; other site 357808008961 putative PBP binding loops; other site 357808008962 ABC-ATPase subunit interface; other site 357808008963 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 357808008964 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 357808008965 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 357808008966 amidase catalytic site [active] 357808008967 Zn binding residues [ion binding]; other site 357808008968 substrate binding site [chemical binding]; other site 357808008969 Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751 357808008970 Cna protein B-type domain; Region: Cna_B_2; pfam13715 357808008971 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808008972 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808008973 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808008974 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 357808008975 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357808008976 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357808008977 TM-ABC transporter signature motif; other site 357808008978 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357808008979 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357808008980 TM-ABC transporter signature motif; other site 357808008981 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357808008982 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357808008983 Walker A/P-loop; other site 357808008984 ATP binding site [chemical binding]; other site 357808008985 Q-loop/lid; other site 357808008986 ABC transporter signature motif; other site 357808008987 Walker B; other site 357808008988 D-loop; other site 357808008989 H-loop/switch region; other site 357808008990 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357808008991 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 357808008992 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357808008993 putative ligand binding site [chemical binding]; other site 357808008994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808008995 active site 357808008996 phosphorylation site [posttranslational modification] 357808008997 intermolecular recognition site; other site 357808008998 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 357808008999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808009000 putative active site [active] 357808009001 heme pocket [chemical binding]; other site 357808009002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808009003 dimer interface [polypeptide binding]; other site 357808009004 phosphorylation site [posttranslational modification] 357808009005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808009006 ATP binding site [chemical binding]; other site 357808009007 Mg2+ binding site [ion binding]; other site 357808009008 G-X-G motif; other site 357808009009 Response regulator receiver domain; Region: Response_reg; pfam00072 357808009010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808009011 active site 357808009012 phosphorylation site [posttranslational modification] 357808009013 intermolecular recognition site; other site 357808009014 dimerization interface [polypeptide binding]; other site 357808009015 Response regulator receiver domain; Region: Response_reg; pfam00072 357808009016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808009017 active site 357808009018 phosphorylation site [posttranslational modification] 357808009019 intermolecular recognition site; other site 357808009020 dimerization interface [polypeptide binding]; other site 357808009021 PAS fold; Region: PAS_4; pfam08448 357808009022 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357808009023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808009024 putative active site [active] 357808009025 heme pocket [chemical binding]; other site 357808009026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808009027 dimer interface [polypeptide binding]; other site 357808009028 phosphorylation site [posttranslational modification] 357808009029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808009030 ATP binding site [chemical binding]; other site 357808009031 Mg2+ binding site [ion binding]; other site 357808009032 G-X-G motif; other site 357808009033 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 357808009034 TrkA-N domain; Region: TrkA_N; pfam02254 357808009035 TrkA-C domain; Region: TrkA_C; pfam02080 357808009036 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 357808009037 TrkA-N domain; Region: TrkA_N; pfam02254 357808009038 TrkA-C domain; Region: TrkA_C; pfam02080 357808009039 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 357808009040 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 357808009041 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357808009042 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 357808009043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808009044 motif II; other site 357808009045 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 357808009046 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 357808009047 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357808009048 ABC-ATPase subunit interface; other site 357808009049 dimer interface [polypeptide binding]; other site 357808009050 putative PBP binding regions; other site 357808009051 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 357808009052 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357808009053 ABC-ATPase subunit interface; other site 357808009054 dimer interface [polypeptide binding]; other site 357808009055 putative PBP binding regions; other site 357808009056 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 357808009057 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 357808009058 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 357808009059 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 357808009060 intersubunit interface [polypeptide binding]; other site 357808009061 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 357808009062 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 357808009063 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 357808009064 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 357808009065 Domain of unknown function (DUF333); Region: DUF333; pfam03891 357808009066 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 357808009067 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 357808009068 catalytic residues [active] 357808009069 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357808009070 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 357808009071 active site 357808009072 catalytic tetrad [active] 357808009073 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 357808009074 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 357808009075 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 357808009076 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 357808009077 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 357808009078 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 357808009079 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 357808009080 aspartate kinase; Provisional; Region: PRK06291 357808009081 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 357808009082 nucleotide binding site [chemical binding]; other site 357808009083 substrate binding site [chemical binding]; other site 357808009084 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 357808009085 dimer interface [polypeptide binding]; other site 357808009086 putative threonine allosteric regulatory site; other site 357808009087 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 357808009088 threonine synthase; Reviewed; Region: PRK06721 357808009089 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 357808009090 homodimer interface [polypeptide binding]; other site 357808009091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808009092 catalytic residue [active] 357808009093 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357808009094 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 357808009095 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 357808009096 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 357808009097 protein binding site [polypeptide binding]; other site 357808009098 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 357808009099 Amidase; Region: Amidase; pfam01425 357808009100 Protein of unknown function DUF72; Region: DUF72; pfam01904 357808009101 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 357808009102 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 357808009103 putative ligand binding site [chemical binding]; other site 357808009104 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 357808009105 dimer interface [polypeptide binding]; other site 357808009106 [2Fe-2S] cluster binding site [ion binding]; other site 357808009107 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 357808009108 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357808009109 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 357808009110 dimer interface [polypeptide binding]; other site 357808009111 putative PBP binding regions; other site 357808009112 ABC-ATPase subunit interface; other site 357808009113 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 357808009114 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 357808009115 Walker A/P-loop; other site 357808009116 ATP binding site [chemical binding]; other site 357808009117 Q-loop/lid; other site 357808009118 ABC transporter signature motif; other site 357808009119 Walker B; other site 357808009120 D-loop; other site 357808009121 H-loop/switch region; other site 357808009122 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 357808009123 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 357808009124 intersubunit interface [polypeptide binding]; other site 357808009125 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 357808009126 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 357808009127 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 357808009128 intersubunit interface [polypeptide binding]; other site 357808009129 chaperone protein DnaJ; Provisional; Region: PRK10767 357808009130 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 357808009131 HSP70 interaction site [polypeptide binding]; other site 357808009132 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 357808009133 substrate binding site [polypeptide binding]; other site 357808009134 dimer interface [polypeptide binding]; other site 357808009135 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 357808009136 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 357808009137 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 357808009138 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 357808009139 active site 357808009140 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 357808009141 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 357808009142 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 357808009143 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 357808009144 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 357808009145 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 357808009146 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 357808009147 Walker A/P-loop; other site 357808009148 ATP binding site [chemical binding]; other site 357808009149 Q-loop/lid; other site 357808009150 ABC transporter signature motif; other site 357808009151 Walker B; other site 357808009152 D-loop; other site 357808009153 H-loop/switch region; other site 357808009154 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 357808009155 Walker A/P-loop; other site 357808009156 ATP binding site [chemical binding]; other site 357808009157 Q-loop/lid; other site 357808009158 ABC transporter signature motif; other site 357808009159 Walker B; other site 357808009160 D-loop; other site 357808009161 H-loop/switch region; other site 357808009162 Cobalt transport protein; Region: CbiQ; cl00463 357808009163 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357808009164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808009165 S-adenosylmethionine binding site [chemical binding]; other site 357808009166 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 357808009167 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 357808009168 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 357808009169 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 357808009170 catalytic residues [active] 357808009171 dimer interface [polypeptide binding]; other site 357808009172 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 357808009173 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 357808009174 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357808009175 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 357808009176 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357808009177 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 357808009178 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 357808009179 4-alpha-glucanotransferase; Provisional; Region: PRK14508 357808009180 Domain of unknown function DUF11; Region: DUF11; pfam01345 357808009181 Domain of unknown function DUF11; Region: DUF11; cl17728 357808009182 Domain of unknown function DUF11; Region: DUF11; pfam01345 357808009183 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 357808009184 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357808009185 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357808009186 catalytic residue [active] 357808009187 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 357808009188 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808009189 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357808009190 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808009191 DNA binding residues [nucleotide binding] 357808009192 CTP synthetase; Validated; Region: pyrG; PRK05380 357808009193 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 357808009194 Catalytic site [active] 357808009195 active site 357808009196 UTP binding site [chemical binding]; other site 357808009197 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 357808009198 active site 357808009199 putative oxyanion hole; other site 357808009200 catalytic triad [active] 357808009201 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 357808009202 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 357808009203 RecX family; Region: RecX; cl00936 357808009204 RecX family; Region: RecX; pfam02631 357808009205 recombinase A; Provisional; Region: recA; PRK09354 357808009206 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 357808009207 hexamer interface [polypeptide binding]; other site 357808009208 Walker A motif; other site 357808009209 ATP binding site [chemical binding]; other site 357808009210 Walker B motif; other site 357808009211 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 357808009212 active site 357808009213 catalytic site [active] 357808009214 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808009215 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808009216 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808009217 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 357808009218 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 357808009219 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 357808009220 metal binding triad [ion binding]; metal-binding site 357808009221 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808009222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808009223 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808009224 Protein of unknown function (DUF433); Region: DUF433; pfam04255 357808009225 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 357808009226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808009227 binding surface 357808009228 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808009229 TPR motif; other site 357808009230 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808009231 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808009232 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808009233 AAA ATPase domain; Region: AAA_16; pfam13191 357808009234 NB-ARC domain; Region: NB-ARC; pfam00931 357808009235 Walker A motif; other site 357808009236 ATP binding site [chemical binding]; other site 357808009237 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357808009238 metal binding site [ion binding]; metal-binding site 357808009239 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 357808009240 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357808009241 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 357808009242 G8 domain; Region: G8; pfam10162 357808009243 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 357808009244 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357808009245 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357808009246 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357808009247 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 357808009248 Uncharacterized conserved protein [Function unknown]; Region: COG0398 357808009249 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 357808009250 short chain dehydrogenase; Provisional; Region: PRK08219 357808009251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808009252 NAD(P) binding site [chemical binding]; other site 357808009253 active site 357808009254 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 357808009255 classical (c) SDRs; Region: SDR_c; cd05233 357808009256 NAD(P) binding site [chemical binding]; other site 357808009257 active site 357808009258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 357808009259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 357808009260 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 357808009261 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 357808009262 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357808009263 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 357808009264 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357808009265 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357808009266 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357808009267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808009268 dimer interface [polypeptide binding]; other site 357808009269 conserved gate region; other site 357808009270 putative PBP binding loops; other site 357808009271 ABC-ATPase subunit interface; other site 357808009272 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 357808009273 O-Antigen ligase; Region: Wzy_C; pfam04932 357808009274 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 357808009275 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 357808009276 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 357808009277 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 357808009278 GIY-YIG motif/motif A; other site 357808009279 active site 357808009280 catalytic site [active] 357808009281 putative DNA binding site [nucleotide binding]; other site 357808009282 metal binding site [ion binding]; metal-binding site 357808009283 UvrB/uvrC motif; Region: UVR; pfam02151 357808009284 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 357808009285 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 357808009286 DNA binding site [nucleotide binding] 357808009287 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 357808009288 BNR repeat-like domain; Region: BNR_2; pfam13088 357808009289 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 357808009290 Asp-box motif; other site 357808009291 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 357808009292 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 357808009293 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808009294 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357808009295 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808009296 DNA binding residues [nucleotide binding] 357808009297 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 357808009298 Protein of unknown function DUF58; Region: DUF58; pfam01882 357808009299 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 357808009300 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 357808009301 trmE is a tRNA modification GTPase; Region: trmE; cd04164 357808009302 G1 box; other site 357808009303 GTP/Mg2+ binding site [chemical binding]; other site 357808009304 Switch I region; other site 357808009305 G2 box; other site 357808009306 Switch II region; other site 357808009307 G3 box; other site 357808009308 G4 box; other site 357808009309 G5 box; other site 357808009310 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 357808009311 Response regulator receiver domain; Region: Response_reg; pfam00072 357808009312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808009313 active site 357808009314 phosphorylation site [posttranslational modification] 357808009315 intermolecular recognition site; other site 357808009316 dimerization interface [polypeptide binding]; other site 357808009317 Helix-turn-helix domain; Region: HTH_25; pfam13413 357808009318 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 357808009319 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 357808009320 NAD(P) binding site [chemical binding]; other site 357808009321 Protein of unknown function (DUF3623); Region: DUF3623; cl11843 357808009322 PUCC protein; Region: PUCC; pfam03209 357808009323 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357808009324 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357808009325 ligand binding site [chemical binding]; other site 357808009326 flexible hinge region; other site 357808009327 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357808009328 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357808009329 ligand binding site [chemical binding]; other site 357808009330 flexible hinge region; other site 357808009331 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 357808009332 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 357808009333 4Fe-4S binding domain; Region: Fer4; pfam00037 357808009334 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 357808009335 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 357808009336 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 357808009337 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 357808009338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808009339 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808009340 active site 357808009341 phosphorylation site [posttranslational modification] 357808009342 intermolecular recognition site; other site 357808009343 dimerization interface [polypeptide binding]; other site 357808009344 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 357808009345 DNA binding residues [nucleotide binding] 357808009346 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 357808009347 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 357808009348 nucleotide binding site [chemical binding]; other site 357808009349 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 357808009350 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 357808009351 dimer interface [polypeptide binding]; other site 357808009352 active site 357808009353 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 357808009354 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 357808009355 carboxyltransferase (CT) interaction site; other site 357808009356 biotinylation site [posttranslational modification]; other site 357808009357 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 357808009358 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 357808009359 generic binding surface II; other site 357808009360 generic binding surface I; other site 357808009361 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 357808009362 Membrane transport protein; Region: Mem_trans; cl09117 357808009363 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 357808009364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808009365 S-adenosylmethionine binding site [chemical binding]; other site 357808009366 YGGT family; Region: YGGT; pfam02325 357808009367 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 357808009368 histidinol dehydrogenase; Region: hisD; TIGR00069 357808009369 NAD binding site [chemical binding]; other site 357808009370 dimerization interface [polypeptide binding]; other site 357808009371 product binding site; other site 357808009372 substrate binding site [chemical binding]; other site 357808009373 zinc binding site [ion binding]; other site 357808009374 catalytic residues [active] 357808009375 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 357808009376 ATP phosphoribosyltransferase; Region: HisG; cl15266 357808009377 HisG, C-terminal domain; Region: HisG_C; cl06867 357808009378 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808009379 putative active site [active] 357808009380 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 357808009381 Domain of unknown function DUF11; Region: DUF11; pfam01345 357808009382 Protein of unknown function DUF58; Region: DUF58; pfam01882 357808009383 MoxR-like ATPases [General function prediction only]; Region: COG0714 357808009384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808009385 Walker A motif; other site 357808009386 ATP binding site [chemical binding]; other site 357808009387 Walker B motif; other site 357808009388 arginine finger; other site 357808009389 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 357808009390 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 357808009391 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 357808009392 dimer interface [polypeptide binding]; other site 357808009393 motif 1; other site 357808009394 active site 357808009395 motif 2; other site 357808009396 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 357808009397 motif 3; other site 357808009398 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 357808009399 anticodon binding site; other site 357808009400 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808009401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808009402 dimer interface [polypeptide binding]; other site 357808009403 phosphorylation site [posttranslational modification] 357808009404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808009405 ATP binding site [chemical binding]; other site 357808009406 G-X-G motif; other site 357808009407 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 357808009408 endonuclease III; Region: ENDO3c; smart00478 357808009409 minor groove reading motif; other site 357808009410 helix-hairpin-helix signature motif; other site 357808009411 substrate binding pocket [chemical binding]; other site 357808009412 active site 357808009413 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 357808009414 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 357808009415 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 357808009416 active site 357808009417 Zn binding site [ion binding]; other site 357808009418 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 357808009419 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 357808009420 putative active site [active] 357808009421 oxyanion strand; other site 357808009422 catalytic triad [active] 357808009423 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 357808009424 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 357808009425 catalytic residues [active] 357808009426 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 357808009427 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 357808009428 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 357808009429 substrate binding site [chemical binding]; other site 357808009430 glutamase interaction surface [polypeptide binding]; other site 357808009431 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 357808009432 MoaE interaction surface [polypeptide binding]; other site 357808009433 MoeB interaction surface [polypeptide binding]; other site 357808009434 thiocarboxylated glycine; other site 357808009435 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 357808009436 MoaE homodimer interface [polypeptide binding]; other site 357808009437 MoaD interaction [polypeptide binding]; other site 357808009438 active site residues [active] 357808009439 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 357808009440 Domain of unknown function DUF21; Region: DUF21; pfam01595 357808009441 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 357808009442 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 357808009443 Transporter associated domain; Region: CorC_HlyC; smart01091 357808009444 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 357808009445 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 357808009446 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 357808009447 short chain dehydrogenase; Provisional; Region: PRK12829 357808009448 classical (c) SDRs; Region: SDR_c; cd05233 357808009449 NAD(P) binding site [chemical binding]; other site 357808009450 active site 357808009451 short chain dehydrogenase; Provisional; Region: PRK07577 357808009452 classical (c) SDRs; Region: SDR_c; cd05233 357808009453 NAD(P) binding site [chemical binding]; other site 357808009454 active site 357808009455 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 357808009456 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357808009457 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357808009458 acyl-activating enzyme (AAE) consensus motif; other site 357808009459 AMP binding site [chemical binding]; other site 357808009460 active site 357808009461 CoA binding site [chemical binding]; other site 357808009462 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357808009463 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 357808009464 substrate binding site [chemical binding]; other site 357808009465 oxyanion hole (OAH) forming residues; other site 357808009466 trimer interface [polypeptide binding]; other site 357808009467 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 357808009468 NAD(P) binding site [chemical binding]; other site 357808009469 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 357808009470 NAD(P) binding site [chemical binding]; other site 357808009471 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 357808009472 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357808009473 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 357808009474 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 357808009475 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357808009476 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 357808009477 NAD(P) binding site [chemical binding]; other site 357808009478 catalytic residues [active] 357808009479 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 357808009480 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 357808009481 NADP binding site [chemical binding]; other site 357808009482 dimer interface [polypeptide binding]; other site 357808009483 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 357808009484 protein binding site [polypeptide binding]; other site 357808009485 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 357808009486 Domain interface; other site 357808009487 Peptide binding site; other site 357808009488 Active site tetrad [active] 357808009489 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 357808009490 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357808009491 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357808009492 Walker A/P-loop; other site 357808009493 ATP binding site [chemical binding]; other site 357808009494 Q-loop/lid; other site 357808009495 ABC transporter signature motif; other site 357808009496 Walker B; other site 357808009497 D-loop; other site 357808009498 H-loop/switch region; other site 357808009499 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 357808009500 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 357808009501 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 357808009502 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357808009503 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357808009504 Walker A/P-loop; other site 357808009505 ATP binding site [chemical binding]; other site 357808009506 Q-loop/lid; other site 357808009507 ABC transporter signature motif; other site 357808009508 Walker B; other site 357808009509 D-loop; other site 357808009510 H-loop/switch region; other site 357808009511 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357808009512 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357808009513 ligand binding site [chemical binding]; other site 357808009514 flexible hinge region; other site 357808009515 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357808009516 HlyD family secretion protein; Region: HlyD_3; pfam13437 357808009517 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 357808009518 [2Fe-2S] cluster binding site [ion binding]; other site 357808009519 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 357808009520 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 357808009521 intersubunit interface [polypeptide binding]; other site 357808009522 active site 357808009523 catalytic residue [active] 357808009524 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 357808009525 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 357808009526 active site 357808009527 Ap6A binding site [chemical binding]; other site 357808009528 nudix motif; other site 357808009529 metal binding site [ion binding]; metal-binding site 357808009530 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 357808009531 dimer interface [polypeptide binding]; other site 357808009532 substrate binding site [chemical binding]; other site 357808009533 metal binding sites [ion binding]; metal-binding site 357808009534 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 357808009535 transcription termination factor Rho; Provisional; Region: rho; PRK09376 357808009536 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 357808009537 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 357808009538 RNA binding site [nucleotide binding]; other site 357808009539 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 357808009540 multimer interface [polypeptide binding]; other site 357808009541 Walker A motif; other site 357808009542 ATP binding site [chemical binding]; other site 357808009543 Walker B motif; other site 357808009544 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 357808009545 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 357808009546 motif 1; other site 357808009547 active site 357808009548 motif 2; other site 357808009549 motif 3; other site 357808009550 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 357808009551 DHHA1 domain; Region: DHHA1; pfam02272 357808009552 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 357808009553 Predicted kinase [General function prediction only]; Region: COG0645 357808009554 Rossmann-like domain; Region: Rossmann-like; pfam10727 357808009555 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 357808009556 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 357808009557 putative active site pocket [active] 357808009558 cleavage site 357808009559 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 357808009560 Thioredoxin; Region: Thioredoxin_4; pfam13462 357808009561 Double zinc ribbon; Region: DZR; pfam12773 357808009562 Protein of unknown function (DUF970); Region: DUF970; cl17525 357808009563 thymidylate kinase; Validated; Region: tmk; PRK00698 357808009564 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 357808009565 TMP-binding site; other site 357808009566 ATP-binding site [chemical binding]; other site 357808009567 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 357808009568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808009569 Walker A motif; other site 357808009570 ATP binding site [chemical binding]; other site 357808009571 Walker B motif; other site 357808009572 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 357808009573 RxxxH motif; other site 357808009574 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 357808009575 predicted active site [active] 357808009576 catalytic triad [active] 357808009577 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 357808009578 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 357808009579 active site 357808009580 multimer interface [polypeptide binding]; other site 357808009581 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 357808009582 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 357808009583 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 357808009584 Predicted transcriptional regulator [Transcription]; Region: COG2345 357808009585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357808009586 dimerization interface [polypeptide binding]; other site 357808009587 putative DNA binding site [nucleotide binding]; other site 357808009588 putative Zn2+ binding site [ion binding]; other site 357808009589 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 357808009590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808009591 NAD(P) binding site [chemical binding]; other site 357808009592 active site 357808009593 hypothetical protein; Validated; Region: PRK07682 357808009594 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357808009595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808009596 homodimer interface [polypeptide binding]; other site 357808009597 catalytic residue [active] 357808009598 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 357808009599 Ligand binding site; other site 357808009600 Putative Catalytic site; other site 357808009601 DXD motif; other site 357808009602 Dehydroquinase class II; Region: DHquinase_II; pfam01220 357808009603 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 357808009604 trimer interface [polypeptide binding]; other site 357808009605 active site 357808009606 dimer interface [polypeptide binding]; other site 357808009607 Right handed beta helix region; Region: Beta_helix; pfam13229 357808009608 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 357808009609 Right handed beta helix region; Region: Beta_helix; pfam13229 357808009610 Right handed beta helix region; Region: Beta_helix; pfam13229 357808009611 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 357808009612 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 357808009613 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 357808009614 nucleotide binding site [chemical binding]; other site 357808009615 NEF interaction site [polypeptide binding]; other site 357808009616 SBD interface [polypeptide binding]; other site 357808009617 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 357808009618 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 357808009619 CoA binding domain; Region: CoA_binding; smart00881 357808009620 CoA-ligase; Region: Ligase_CoA; pfam00549 357808009621 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 357808009622 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357808009623 catalytic residue [active] 357808009624 Low molecular weight phosphatase family; Region: LMWPc; cd00115 357808009625 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 357808009626 active site 357808009627 AAA ATPase domain; Region: AAA_16; pfam13191 357808009628 Caspase domain; Region: Peptidase_C14; pfam00656 357808009629 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808009630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808009631 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808009632 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 357808009633 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 357808009634 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 357808009635 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 357808009636 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 357808009637 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 357808009638 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 357808009639 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357808009640 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 357808009641 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 357808009642 putative NAD(P) binding site [chemical binding]; other site 357808009643 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 357808009644 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357808009645 Ligand Binding Site [chemical binding]; other site 357808009646 Protein of unknown function (DUF3623); Region: DUF3623; pfam12291 357808009647 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 357808009648 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 357808009649 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 357808009650 UbiA prenyltransferase family; Region: UbiA; pfam01040 357808009651 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263 357808009652 subunit interface [polypeptide binding]; other site 357808009653 Heme binding sites [chemical binding]; other site 357808009654 bifunctional photosynthetic reaction center subunit L/M; Provisional; Region: PRK14505 357808009655 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 357808009656 subunit M interface; other site 357808009657 subunit H interface; other site 357808009658 quinone binding site; other site 357808009659 bacteriopheophytin binding site; other site 357808009660 bacteriochlorophyll binding site; other site 357808009661 cytochrome C subunit interface; other site 357808009662 Fe binding site [ion binding]; other site 357808009663 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 357808009664 subunit H interface; other site 357808009665 subunit L interface; other site 357808009666 bacteriopheophytin binding site; other site 357808009667 carotenoid binding site; other site 357808009668 bacteriochlorophyll binding site; other site 357808009669 cytochrome C interface; other site 357808009670 quinone binding site; other site 357808009671 Fe binding site [ion binding]; other site 357808009672 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 357808009673 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 357808009674 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 357808009675 DNA binding residues [nucleotide binding] 357808009676 B12 binding domain; Region: B12-binding_2; pfam02607 357808009677 B12 binding domain; Region: B12-binding; pfam02310 357808009678 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 357808009679 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 357808009680 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357808009681 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808009682 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808009683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 357808009684 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 357808009685 Uncharacterized conserved protein [Function unknown]; Region: COG2308 357808009686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357808009687 Histidine kinase; Region: HisKA_3; pfam07730 357808009688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808009689 ATP binding site [chemical binding]; other site 357808009690 Mg2+ binding site [ion binding]; other site 357808009691 G-X-G motif; other site 357808009692 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808009693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808009694 active site 357808009695 phosphorylation site [posttranslational modification] 357808009696 intermolecular recognition site; other site 357808009697 dimerization interface [polypeptide binding]; other site 357808009698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808009699 DNA binding residues [nucleotide binding] 357808009700 dimerization interface [polypeptide binding]; other site 357808009701 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 357808009702 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357808009703 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 357808009704 substrate binding site [chemical binding]; other site 357808009705 dimer interface [polypeptide binding]; other site 357808009706 ATP binding site [chemical binding]; other site 357808009707 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 357808009708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808009709 motif I; other site 357808009710 motif II; other site 357808009711 LrgA family; Region: LrgA; pfam03788 357808009712 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 357808009713 short chain dehydrogenase; Provisional; Region: PRK06172 357808009714 classical (c) SDRs; Region: SDR_c; cd05233 357808009715 NAD(P) binding site [chemical binding]; other site 357808009716 active site 357808009717 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 357808009718 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 357808009719 Protein of unknown function DUF58; Region: DUF58; pfam01882 357808009720 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 357808009721 anti sigma factor interaction site; other site 357808009722 regulatory phosphorylation site [posttranslational modification]; other site 357808009723 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 357808009724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808009725 ATP binding site [chemical binding]; other site 357808009726 Mg2+ binding site [ion binding]; other site 357808009727 G-X-G motif; other site 357808009728 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 357808009729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808009730 ATP binding site [chemical binding]; other site 357808009731 Mg2+ binding site [ion binding]; other site 357808009732 G-X-G motif; other site 357808009733 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 357808009734 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 357808009735 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 357808009736 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357808009737 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357808009738 catalytic residues [active] 357808009739 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 357808009740 putative homodimer interface [polypeptide binding]; other site 357808009741 putative homotetramer interface [polypeptide binding]; other site 357808009742 putative allosteric switch controlling residues; other site 357808009743 putative metal binding site [ion binding]; other site 357808009744 putative homodimer-homodimer interface [polypeptide binding]; other site 357808009745 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 357808009746 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 357808009747 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 357808009748 hydroxyglutarate oxidase; Provisional; Region: PRK11728 357808009749 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 357808009750 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 357808009751 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 357808009752 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 357808009753 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 357808009754 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357808009755 Cysteine-rich domain; Region: CCG; pfam02754 357808009756 Cysteine-rich domain; Region: CCG; pfam02754 357808009757 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 357808009758 active pocket/dimerization site; other site 357808009759 active site 357808009760 phosphorylation site [posttranslational modification] 357808009761 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 357808009762 dimerization domain swap beta strand [polypeptide binding]; other site 357808009763 regulatory protein interface [polypeptide binding]; other site 357808009764 active site 357808009765 regulatory phosphorylation site [posttranslational modification]; other site 357808009766 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 357808009767 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 357808009768 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 357808009769 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 357808009770 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808009771 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808009772 active site 357808009773 ATP binding site [chemical binding]; other site 357808009774 substrate binding site [chemical binding]; other site 357808009775 activation loop (A-loop); other site 357808009776 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 357808009777 PemK-like protein; Region: PemK; cl00995 357808009778 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 357808009779 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808009780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808009781 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808009782 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 357808009783 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 357808009784 Ca binding site [ion binding]; other site 357808009785 active site 357808009786 catalytic site [active] 357808009787 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 357808009788 HD domain; Region: HD_3; pfam13023 357808009789 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 357808009790 metal binding site [ion binding]; metal-binding site 357808009791 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 357808009792 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 357808009793 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 357808009794 YacP-like NYN domain; Region: NYN_YacP; cl01491 357808009795 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 357808009796 active site 357808009797 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 357808009798 dimerization interface [polypeptide binding]; other site 357808009799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808009800 Radical SAM superfamily; Region: Radical_SAM; pfam04055 357808009801 FeS/SAM binding site; other site 357808009802 threonine dehydratase; Provisional; Region: PRK08198 357808009803 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 357808009804 tetramer interface [polypeptide binding]; other site 357808009805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808009806 catalytic residue [active] 357808009807 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 357808009808 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 357808009809 HEAT repeats; Region: HEAT_2; pfam13646 357808009810 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 357808009811 DNA binding site [nucleotide binding] 357808009812 Bacterial transcriptional activator domain; Region: BTAD; smart01043 357808009813 elongation factor Tu; Reviewed; Region: PRK00049 357808009814 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 357808009815 G1 box; other site 357808009816 GEF interaction site [polypeptide binding]; other site 357808009817 GTP/Mg2+ binding site [chemical binding]; other site 357808009818 Switch I region; other site 357808009819 G2 box; other site 357808009820 G3 box; other site 357808009821 Switch II region; other site 357808009822 G4 box; other site 357808009823 G5 box; other site 357808009824 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 357808009825 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 357808009826 Antibiotic Binding Site [chemical binding]; other site 357808009827 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 357808009828 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 357808009829 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 357808009830 putative homodimer interface [polypeptide binding]; other site 357808009831 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 357808009832 heterodimer interface [polypeptide binding]; other site 357808009833 homodimer interface [polypeptide binding]; other site 357808009834 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 357808009835 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 357808009836 23S rRNA interface [nucleotide binding]; other site 357808009837 L7/L12 interface [polypeptide binding]; other site 357808009838 putative thiostrepton binding site; other site 357808009839 L25 interface [polypeptide binding]; other site 357808009840 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 357808009841 mRNA/rRNA interface [nucleotide binding]; other site 357808009842 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 357808009843 23S rRNA interface [nucleotide binding]; other site 357808009844 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 357808009845 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 357808009846 L11 interface [polypeptide binding]; other site 357808009847 putative EF-Tu interaction site [polypeptide binding]; other site 357808009848 putative EF-G interaction site [polypeptide binding]; other site 357808009849 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357808009850 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 357808009851 active site 357808009852 HIGH motif; other site 357808009853 nucleotide binding site [chemical binding]; other site 357808009854 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 357808009855 KMSKS motif; other site 357808009856 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 357808009857 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 357808009858 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 357808009859 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 357808009860 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 357808009861 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 357808009862 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 357808009863 active site 357808009864 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 357808009865 ATP-sulfurylase; Region: ATPS; cd00517 357808009866 active site 357808009867 HXXH motif; other site 357808009868 flexible loop; other site 357808009869 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 357808009870 ligand-binding site [chemical binding]; other site 357808009871 Uncharacterized conserved protein [Function unknown]; Region: COG3379 357808009872 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 357808009873 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 357808009874 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 357808009875 Sulfatase; Region: Sulfatase; cl17466 357808009876 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 357808009877 Aspartase; Region: Aspartase; cd01357 357808009878 active sites [active] 357808009879 tetramer interface [polypeptide binding]; other site 357808009880 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 357808009881 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cd08368 357808009882 Zn binding site [ion binding]; other site 357808009883 Protein of unknown function (DUF3633); Region: DUF3633; pfam12315 357808009884 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 357808009885 Zn binding site [ion binding]; other site 357808009886 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 357808009887 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 357808009888 PCRF domain; Region: PCRF; pfam03462 357808009889 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 357808009890 RF-1 domain; Region: RF-1; pfam00472 357808009891 TadE-like protein; Region: TadE; pfam07811 357808009892 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 357808009893 metal ion-dependent adhesion site (MIDAS); other site 357808009894 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 357808009895 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 357808009896 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357808009897 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 357808009898 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 357808009899 ATP binding site [chemical binding]; other site 357808009900 Walker A motif; other site 357808009901 hexamer interface [polypeptide binding]; other site 357808009902 Walker B motif; other site 357808009903 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808009904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808009905 active site 357808009906 phosphorylation site [posttranslational modification] 357808009907 dimerization interface [polypeptide binding]; other site 357808009908 septum site-determining protein MinD; Region: minD_bact; TIGR01968 357808009909 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 357808009910 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357808009911 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 357808009912 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 357808009913 Response regulator receiver domain; Region: Response_reg; pfam00072 357808009914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808009915 active site 357808009916 phosphorylation site [posttranslational modification] 357808009917 intermolecular recognition site; other site 357808009918 dimerization interface [polypeptide binding]; other site 357808009919 PAS fold; Region: PAS_4; pfam08448 357808009920 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 357808009921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808009922 dimer interface [polypeptide binding]; other site 357808009923 phosphorylation site [posttranslational modification] 357808009924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808009925 ATP binding site [chemical binding]; other site 357808009926 Mg2+ binding site [ion binding]; other site 357808009927 G-X-G motif; other site 357808009928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 357808009929 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357808009930 active site 357808009931 phosphorylation site [posttranslational modification] 357808009932 intermolecular recognition site; other site 357808009933 dimerization interface [polypeptide binding]; other site 357808009934 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 357808009935 tetramer interface [polypeptide binding]; other site 357808009936 dimer interface [polypeptide binding]; other site 357808009937 circadian clock protein KaiC; Reviewed; Region: PRK09302 357808009938 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 357808009939 Walker A motif; other site 357808009940 ATP binding site [chemical binding]; other site 357808009941 Walker B motif; other site 357808009942 recA bacterial DNA recombination protein; Region: RecA; cl17211 357808009943 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357808009944 Walker A motif; other site 357808009945 ATP binding site [chemical binding]; other site 357808009946 Walker B motif; other site 357808009947 FAD binding domain; Region: FAD_binding_4; pfam01565 357808009948 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 357808009949 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 357808009950 FAD binding domain; Region: FAD_binding_4; pfam01565 357808009951 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 357808009952 methionine sulfoxide reductase A; Provisional; Region: PRK14054 357808009953 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 357808009954 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 357808009955 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 357808009956 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 357808009957 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 357808009958 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357808009959 Probable Catalytic site; other site 357808009960 metal-binding site 357808009961 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808009962 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808009963 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808009964 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 357808009965 PAS fold; Region: PAS; pfam00989 357808009966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808009967 putative active site [active] 357808009968 heme pocket [chemical binding]; other site 357808009969 PAS domain; Region: PAS; smart00091 357808009970 PAS domain; Region: PAS_9; pfam13426 357808009971 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808009972 GAF domain; Region: GAF; pfam01590 357808009973 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357808009974 Zn2+ binding site [ion binding]; other site 357808009975 Mg2+ binding site [ion binding]; other site 357808009976 Fatty acid desaturase; Region: FA_desaturase; pfam00487 357808009977 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 357808009978 putative di-iron ligands [ion binding]; other site 357808009979 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 357808009980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808009981 Walker A motif; other site 357808009982 ATP binding site [chemical binding]; other site 357808009983 Walker B motif; other site 357808009984 arginine finger; other site 357808009985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808009986 Walker A motif; other site 357808009987 ATP binding site [chemical binding]; other site 357808009988 Walker B motif; other site 357808009989 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 357808009990 FOG: WD40 repeat [General function prediction only]; Region: COG2319 357808009991 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 357808009992 structural tetrad; other site 357808009993 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 357808009994 active site 357808009995 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808009996 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808009997 phosphopeptide binding site; other site 357808009998 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808009999 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808010000 active site 357808010001 ATP binding site [chemical binding]; other site 357808010002 substrate binding site [chemical binding]; other site 357808010003 activation loop (A-loop); other site 357808010004 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808010005 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808010006 active site 357808010007 ATP binding site [chemical binding]; other site 357808010008 substrate binding site [chemical binding]; other site 357808010009 activation loop (A-loop); other site 357808010010 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 357808010011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808010012 binding surface 357808010013 TPR motif; other site 357808010014 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 357808010015 FOG: WD40 repeat [General function prediction only]; Region: COG2319 357808010016 structural tetrad; other site 357808010017 FOG: WD40 repeat [General function prediction only]; Region: COG2319 357808010018 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 357808010019 structural tetrad; other site 357808010020 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 357808010021 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 357808010022 metal ion-dependent adhesion site (MIDAS); other site 357808010023 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808010024 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808010025 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808010026 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808010027 active site 357808010028 ATP binding site [chemical binding]; other site 357808010029 substrate binding site [chemical binding]; other site 357808010030 activation loop (A-loop); other site 357808010031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808010032 binding surface 357808010033 Tetratricopeptide repeat; Region: TPR_16; pfam13432 357808010034 TPR motif; other site 357808010035 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 357808010036 structural tetrad; other site 357808010037 FOG: WD40 repeat [General function prediction only]; Region: COG2319 357808010038 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 357808010039 structural tetrad; other site 357808010040 FOG: WD40 repeat [General function prediction only]; Region: COG2319 357808010041 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808010042 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808010043 phosphopeptide binding site; other site 357808010044 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808010045 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808010046 putative peptide-modifying radical SAM enzyme, Mhun_1560 family; Region: rSAM_pep_methan; TIGR04083 357808010047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808010048 FeS/SAM binding site; other site 357808010049 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 357808010050 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 357808010051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808010052 FeS/SAM binding site; other site 357808010053 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 357808010054 HEAT repeats; Region: HEAT_2; pfam13646 357808010055 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 357808010056 HEAT repeats; Region: HEAT_2; pfam13646 357808010057 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 357808010058 HEAT repeats; Region: HEAT_2; pfam13646 357808010059 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 357808010060 protein binding surface [polypeptide binding]; other site 357808010061 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 357808010062 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 357808010063 protein binding surface [polypeptide binding]; other site 357808010064 HEAT repeats; Region: HEAT_2; pfam13646 357808010065 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 357808010066 protein binding surface [polypeptide binding]; other site 357808010067 HEAT repeats; Region: HEAT_2; pfam13646 357808010068 AAA domain; Region: AAA_28; pfam13521 357808010069 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 357808010070 HEAT-like repeat; Region: HEAT_EZ; pfam13513 357808010071 protein binding surface [polypeptide binding]; other site 357808010072 HEAT repeats; Region: HEAT_2; pfam13646 357808010073 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 357808010074 HEAT repeats; Region: HEAT_2; pfam13646 357808010075 protein binding surface [polypeptide binding]; other site 357808010076 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 357808010077 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 357808010078 TPP-binding site [chemical binding]; other site 357808010079 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 357808010080 dimer interface [polypeptide binding]; other site 357808010081 PYR/PP interface [polypeptide binding]; other site 357808010082 TPP binding site [chemical binding]; other site 357808010083 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 357808010084 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 357808010085 E3 interaction surface; other site 357808010086 lipoyl attachment site [posttranslational modification]; other site 357808010087 e3 binding domain; Region: E3_binding; pfam02817 357808010088 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 357808010089 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 357808010090 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 357808010091 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 357808010092 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 357808010093 dimer interface [polypeptide binding]; other site 357808010094 ssDNA binding site [nucleotide binding]; other site 357808010095 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357808010096 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 357808010097 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 357808010098 FOG: CBS domain [General function prediction only]; Region: COG0517 357808010099 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 357808010100 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 357808010101 SCP-2 sterol transfer family; Region: SCP2; pfam02036 357808010102 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 357808010103 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808010104 putative active site [active] 357808010105 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808010106 putative active site [active] 357808010107 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 357808010108 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 357808010109 putative substrate binding site [chemical binding]; other site 357808010110 putative ATP binding site [chemical binding]; other site 357808010111 elongation factor P; Validated; Region: PRK00529 357808010112 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 357808010113 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 357808010114 RNA binding site [nucleotide binding]; other site 357808010115 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 357808010116 RNA binding site [nucleotide binding]; other site 357808010117 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 357808010118 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 357808010119 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 357808010120 Ligand binding site; other site 357808010121 Putative Catalytic site; other site 357808010122 DXD motif; other site 357808010123 DNA polymerase I; Provisional; Region: PRK05755 357808010124 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 357808010125 active site 357808010126 metal binding site 1 [ion binding]; metal-binding site 357808010127 putative 5' ssDNA interaction site; other site 357808010128 metal binding site 3; metal-binding site 357808010129 metal binding site 2 [ion binding]; metal-binding site 357808010130 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 357808010131 putative DNA binding site [nucleotide binding]; other site 357808010132 putative metal binding site [ion binding]; other site 357808010133 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 357808010134 active site 357808010135 catalytic site [active] 357808010136 substrate binding site [chemical binding]; other site 357808010137 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 357808010138 active site 357808010139 DNA binding site [nucleotide binding] 357808010140 catalytic site [active] 357808010141 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 357808010142 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357808010143 FtsX-like permease family; Region: FtsX; pfam02687 357808010144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357808010145 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 357808010146 Histidine kinase; Region: HisKA_3; pfam07730 357808010147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808010148 ATP binding site [chemical binding]; other site 357808010149 Mg2+ binding site [ion binding]; other site 357808010150 G-X-G motif; other site 357808010151 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808010152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808010153 active site 357808010154 phosphorylation site [posttranslational modification] 357808010155 intermolecular recognition site; other site 357808010156 dimerization interface [polypeptide binding]; other site 357808010157 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808010158 DNA binding residues [nucleotide binding] 357808010159 dimerization interface [polypeptide binding]; other site 357808010160 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357808010161 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 357808010162 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 357808010163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808010164 S-adenosylmethionine binding site [chemical binding]; other site 357808010165 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 357808010166 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 357808010167 putative active site [active] 357808010168 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 357808010169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808010170 Coenzyme A binding pocket [chemical binding]; other site 357808010171 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 357808010172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 357808010173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808010174 ATP binding site [chemical binding]; other site 357808010175 putative Mg++ binding site [ion binding]; other site 357808010176 nucleotide binding region [chemical binding]; other site 357808010177 helicase superfamily c-terminal domain; Region: HELICc; smart00490 357808010178 ATP-binding site [chemical binding]; other site 357808010179 DEAD/H associated; Region: DEAD_assoc; pfam08494 357808010180 PUCC protein; Region: PUCC; pfam03209 357808010181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808010182 putative substrate translocation pore; other site 357808010183 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 357808010184 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357808010185 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 357808010186 active site 357808010187 catalytic tetrad [active] 357808010188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808010189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808010190 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357808010191 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808010192 active site 357808010193 NTP binding site [chemical binding]; other site 357808010194 metal binding triad [ion binding]; metal-binding site 357808010195 antibiotic binding site [chemical binding]; other site 357808010196 HEPN domain; Region: HEPN; pfam05168 357808010197 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 357808010198 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357808010199 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357808010200 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 357808010201 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 357808010202 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 357808010203 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 357808010204 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 357808010205 Trm112p-like protein; Region: Trm112p; cl01066 357808010206 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 357808010207 putative active site [active] 357808010208 putative metal binding site [ion binding]; other site 357808010209 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357808010210 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 357808010211 active site 357808010212 Uncharacterized conserved protein [Function unknown]; Region: COG1432 357808010213 LabA_like proteins; Region: LabA_like; cd06167 357808010214 putative metal binding site [ion binding]; other site 357808010215 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 357808010216 DNA photolyase; Region: DNA_photolyase; pfam00875 357808010217 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808010218 active site 357808010219 NTP binding site [chemical binding]; other site 357808010220 metal binding triad [ion binding]; metal-binding site 357808010221 antibiotic binding site [chemical binding]; other site 357808010222 TPR repeat; Region: TPR_11; pfam13414 357808010223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808010224 binding surface 357808010225 TPR motif; other site 357808010226 TPR repeat; Region: TPR_11; pfam13414 357808010227 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357808010228 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 357808010229 Walker A/P-loop; other site 357808010230 ATP binding site [chemical binding]; other site 357808010231 Q-loop/lid; other site 357808010232 ABC transporter signature motif; other site 357808010233 Walker B; other site 357808010234 D-loop; other site 357808010235 H-loop/switch region; other site 357808010236 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357808010237 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 357808010238 Walker A/P-loop; other site 357808010239 ATP binding site [chemical binding]; other site 357808010240 Q-loop/lid; other site 357808010241 ABC transporter signature motif; other site 357808010242 Walker B; other site 357808010243 D-loop; other site 357808010244 H-loop/switch region; other site 357808010245 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 357808010246 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 357808010247 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808010248 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808010249 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357808010250 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 357808010251 putative substrate binding site [chemical binding]; other site 357808010252 putative ATP binding site [chemical binding]; other site 357808010253 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 357808010254 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808010255 active site 357808010256 NTP binding site [chemical binding]; other site 357808010257 metal binding triad [ion binding]; metal-binding site 357808010258 antibiotic binding site [chemical binding]; other site 357808010259 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 357808010260 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 357808010261 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 357808010262 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 357808010263 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 357808010264 HSP70 interaction site [polypeptide binding]; other site 357808010265 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 357808010266 substrate binding site [polypeptide binding]; other site 357808010267 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 357808010268 Zn binding sites [ion binding]; other site 357808010269 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 357808010270 dimer interface [polypeptide binding]; other site 357808010271 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 357808010272 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 357808010273 nucleotide binding site [chemical binding]; other site 357808010274 NEF interaction site [polypeptide binding]; other site 357808010275 SBD interface [polypeptide binding]; other site 357808010276 GrpE; Region: GrpE; pfam01025 357808010277 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 357808010278 dimer interface [polypeptide binding]; other site 357808010279 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 357808010280 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 357808010281 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 357808010282 nudix motif; other site 357808010283 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 357808010284 putative active site [active] 357808010285 nucleotide binding site [chemical binding]; other site 357808010286 nudix motif; other site 357808010287 putative metal binding site [ion binding]; other site 357808010288 seryl-tRNA synthetase; Provisional; Region: PRK05431 357808010289 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 357808010290 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 357808010291 dimer interface [polypeptide binding]; other site 357808010292 active site 357808010293 motif 1; other site 357808010294 motif 2; other site 357808010295 motif 3; other site 357808010296 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 357808010297 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 357808010298 dimer interface [polypeptide binding]; other site 357808010299 active site 357808010300 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 357808010301 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 357808010302 Protein of unknown function (DUF970); Region: DUF970; cl17525 357808010303 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808010304 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 357808010305 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808010306 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808010307 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808010308 dimerization interface [polypeptide binding]; other site 357808010309 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808010310 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 357808010311 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357808010312 Pyruvate formate lyase; Region: PFL; pfam02901 357808010313 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 357808010314 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808010315 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 357808010316 catalytic triad [active] 357808010317 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357808010318 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357808010319 YceI-like domain; Region: YceI; pfam04264 357808010320 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 357808010321 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 357808010322 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 357808010323 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 357808010324 Protein of unknown function (DUF461); Region: DUF461; pfam04314 357808010325 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 357808010326 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808010327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808010328 active site 357808010329 phosphorylation site [posttranslational modification] 357808010330 intermolecular recognition site; other site 357808010331 dimerization interface [polypeptide binding]; other site 357808010332 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808010333 DNA binding site [nucleotide binding] 357808010334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808010335 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808010336 dimerization interface [polypeptide binding]; other site 357808010337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808010338 dimer interface [polypeptide binding]; other site 357808010339 phosphorylation site [posttranslational modification] 357808010340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808010341 ATP binding site [chemical binding]; other site 357808010342 Mg2+ binding site [ion binding]; other site 357808010343 G-X-G motif; other site 357808010344 Winged helix-turn helix; Region: HTH_29; pfam13551 357808010345 Homeodomain-like domain; Region: HTH_32; pfam13565 357808010346 Winged helix-turn helix; Region: HTH_33; pfam13592 357808010347 DDE superfamily endonuclease; Region: DDE_3; pfam13358 357808010348 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 357808010349 Citrate synthase; Region: Citrate_synt; pfam00285 357808010350 oxalacetate binding site [chemical binding]; other site 357808010351 citrylCoA binding site [chemical binding]; other site 357808010352 coenzyme A binding site [chemical binding]; other site 357808010353 catalytic triad [active] 357808010354 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 357808010355 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357808010356 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 357808010357 NAD(P) binding site [chemical binding]; other site 357808010358 catalytic residues [active] 357808010359 Bacterial transcriptional activator domain; Region: BTAD; smart01043 357808010360 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 357808010361 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 357808010362 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 357808010363 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 357808010364 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 357808010365 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 357808010366 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 357808010367 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 357808010368 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808010369 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808010370 phosphopeptide binding site; other site 357808010371 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 357808010372 von Willebrand factor type A domain; Region: VWA_2; pfam13519 357808010373 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808010374 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808010375 active site 357808010376 ATP binding site [chemical binding]; other site 357808010377 substrate binding site [chemical binding]; other site 357808010378 activation loop (A-loop); other site 357808010379 Bacterial SH3 domain; Region: SH3_3; pfam08239 357808010380 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 357808010381 active site 357808010382 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 357808010383 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 357808010384 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 357808010385 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 357808010386 CHAP domain; Region: CHAP; cl17642 357808010387 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 357808010388 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808010389 active site 357808010390 NTP binding site [chemical binding]; other site 357808010391 metal binding triad [ion binding]; metal-binding site 357808010392 antibiotic binding site [chemical binding]; other site 357808010393 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 357808010394 EamA-like transporter family; Region: EamA; pfam00892 357808010395 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808010396 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 357808010397 substrate binding pocket [chemical binding]; other site 357808010398 substrate-Mg2+ binding site; other site 357808010399 aspartate-rich region 1; other site 357808010400 aspartate-rich region 2; other site 357808010401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808010402 S-adenosylmethionine binding site [chemical binding]; other site 357808010403 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357808010404 Beta-lactamase; Region: Beta-lactamase; pfam00144 357808010405 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 357808010406 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 357808010407 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 357808010408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808010409 motif II; other site 357808010410 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808010411 active site 357808010412 NTP binding site [chemical binding]; other site 357808010413 metal binding triad [ion binding]; metal-binding site 357808010414 antibiotic binding site [chemical binding]; other site 357808010415 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 357808010416 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 357808010417 generic binding surface II; other site 357808010418 ssDNA binding site; other site 357808010419 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808010420 ATP binding site [chemical binding]; other site 357808010421 putative Mg++ binding site [ion binding]; other site 357808010422 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808010423 nucleotide binding region [chemical binding]; other site 357808010424 ATP-binding site [chemical binding]; other site 357808010425 EDD domain protein, DegV family; Region: DegV; TIGR00762 357808010426 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 357808010427 EDD domain protein, DegV family; Region: DegV; TIGR00762 357808010428 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 357808010429 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 357808010430 DAK2 domain; Region: Dak2; pfam02734 357808010431 Ribosomal L28 family; Region: Ribosomal_L28; pfam00830 357808010432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808010433 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 357808010434 active site 357808010435 motif I; other site 357808010436 motif II; other site 357808010437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808010438 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 357808010439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808010440 S-adenosylmethionine binding site [chemical binding]; other site 357808010441 SpoVR like protein; Region: SpoVR; pfam04293 357808010442 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 357808010443 hypothetical protein; Provisional; Region: PRK05325 357808010444 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 357808010445 AAA ATPase domain; Region: AAA_16; pfam13191 357808010446 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 357808010447 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 357808010448 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 357808010449 Dynamin family; Region: Dynamin_N; pfam00350 357808010450 G1 box; other site 357808010451 GTP/Mg2+ binding site [chemical binding]; other site 357808010452 G2 box; other site 357808010453 Switch I region; other site 357808010454 G3 box; other site 357808010455 Switch II region; other site 357808010456 G4 box; other site 357808010457 G5 box; other site 357808010458 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 357808010459 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 357808010460 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357808010461 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 357808010462 PAS domain S-box; Region: sensory_box; TIGR00229 357808010463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808010464 putative active site [active] 357808010465 heme pocket [chemical binding]; other site 357808010466 PAS fold; Region: PAS_4; pfam08448 357808010467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808010468 putative active site [active] 357808010469 heme pocket [chemical binding]; other site 357808010470 PAS domain S-box; Region: sensory_box; TIGR00229 357808010471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808010472 putative active site [active] 357808010473 heme pocket [chemical binding]; other site 357808010474 PAS fold; Region: PAS_4; pfam08448 357808010475 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808010476 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 357808010477 Thioredoxin; Region: Thioredoxin_4; pfam13462 357808010478 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 357808010479 nickel binding site [ion binding]; other site 357808010480 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 357808010481 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 357808010482 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 357808010483 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 357808010484 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357808010485 catalytic loop [active] 357808010486 iron binding site [ion binding]; other site 357808010487 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 357808010488 4Fe-4S binding domain; Region: Fer4; cl02805 357808010489 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 357808010490 dimer interface [polypeptide binding]; other site 357808010491 [2Fe-2S] cluster binding site [ion binding]; other site 357808010492 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 357808010493 SLBB domain; Region: SLBB; pfam10531 357808010494 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 357808010495 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 357808010496 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 357808010497 putative dimer interface [polypeptide binding]; other site 357808010498 [2Fe-2S] cluster binding site [ion binding]; other site 357808010499 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 357808010500 metal ion-dependent adhesion site (MIDAS); other site 357808010501 CARDB; Region: CARDB; pfam07705 357808010502 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 357808010503 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 357808010504 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 357808010505 metal ion-dependent adhesion site (MIDAS); other site 357808010506 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 357808010507 FixH; Region: FixH; pfam05751 357808010508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 357808010509 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 357808010510 Membrane protein of unknown function; Region: DUF360; pfam04020 357808010511 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808010512 putative active site [active] 357808010513 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 357808010514 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357808010515 putative active site [active] 357808010516 putative metal binding site [ion binding]; other site 357808010517 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 357808010518 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 357808010519 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 357808010520 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808010521 putative active site [active] 357808010522 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808010523 putative active site [active] 357808010524 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 357808010525 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 357808010526 catalytic triad [active] 357808010527 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808010528 active site 357808010529 NTP binding site [chemical binding]; other site 357808010530 metal binding triad [ion binding]; metal-binding site 357808010531 antibiotic binding site [chemical binding]; other site 357808010532 Uncharacterized conserved protein [Function unknown]; Region: COG2361 357808010533 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 357808010534 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357808010535 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357808010536 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 357808010537 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 357808010538 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 357808010539 Protein of unknown function (DUF499); Region: DUF499; pfam04465 357808010540 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 357808010541 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 357808010542 Walker A/P-loop; other site 357808010543 ATP binding site [chemical binding]; other site 357808010544 Q-loop/lid; other site 357808010545 ABC transporter signature motif; other site 357808010546 Walker B; other site 357808010547 D-loop; other site 357808010548 H-loop/switch region; other site 357808010549 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 357808010550 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 357808010551 putative hemin binding site; other site 357808010552 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357808010553 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 357808010554 putative PBP binding regions; other site 357808010555 ABC-ATPase subunit interface; other site 357808010556 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 357808010557 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 357808010558 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 357808010559 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 357808010560 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 357808010561 FeoA domain; Region: FeoA; pfam04023 357808010562 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 357808010563 GTPase CgtA; Reviewed; Region: obgE; PRK12297 357808010564 GTP1/OBG; Region: GTP1_OBG; pfam01018 357808010565 Obg GTPase; Region: Obg; cd01898 357808010566 G1 box; other site 357808010567 GTP/Mg2+ binding site [chemical binding]; other site 357808010568 Switch I region; other site 357808010569 G2 box; other site 357808010570 G3 box; other site 357808010571 Switch II region; other site 357808010572 G4 box; other site 357808010573 G5 box; other site 357808010574 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 357808010575 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 357808010576 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 357808010577 Bacterial sugar transferase; Region: Bac_transf; pfam02397 357808010578 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357808010579 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 357808010580 NAD binding site [chemical binding]; other site 357808010581 putative substrate binding site 2 [chemical binding]; other site 357808010582 putative substrate binding site 1 [chemical binding]; other site 357808010583 active site 357808010584 O-Antigen ligase; Region: Wzy_C; pfam04932 357808010585 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 357808010586 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357808010587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808010588 NAD(P) binding site [chemical binding]; other site 357808010589 active site 357808010590 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 357808010591 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 357808010592 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808010593 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 357808010594 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 357808010595 N- and C-terminal domain interface [polypeptide binding]; other site 357808010596 active site 357808010597 catalytic site [active] 357808010598 metal binding site [ion binding]; metal-binding site 357808010599 carbohydrate binding site [chemical binding]; other site 357808010600 ATP binding site [chemical binding]; other site 357808010601 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 357808010602 DNA polymerase III subunit delta'; Validated; Region: PRK08485 357808010603 Response regulator receiver domain; Region: Response_reg; pfam00072 357808010604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808010605 active site 357808010606 phosphorylation site [posttranslational modification] 357808010607 intermolecular recognition site; other site 357808010608 dimerization interface [polypeptide binding]; other site 357808010609 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 357808010610 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 357808010611 dimer interface [polypeptide binding]; other site 357808010612 active site 357808010613 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 357808010614 PLD-like domain; Region: PLDc_2; pfam13091 357808010615 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 357808010616 putative active site [active] 357808010617 catalytic site [active] 357808010618 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 357808010619 PLD-like domain; Region: PLDc_2; pfam13091 357808010620 putative active site [active] 357808010621 catalytic site [active] 357808010622 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808010623 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 357808010624 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 357808010625 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 357808010626 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 357808010627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808010628 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357808010629 Zn2+ binding site [ion binding]; other site 357808010630 Mg2+ binding site [ion binding]; other site 357808010631 Yqey-like protein; Region: YqeY; pfam09424 357808010632 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 357808010633 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 357808010634 catalytic site [active] 357808010635 G-X2-G-X-G-K; other site 357808010636 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 357808010637 Domain of unknown function (DUF814); Region: DUF814; pfam05670 357808010638 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 357808010639 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357808010640 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357808010641 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 357808010642 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 357808010643 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 357808010644 carboxyltransferase (CT) interaction site; other site 357808010645 biotinylation site [posttranslational modification]; other site 357808010646 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 357808010647 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 357808010648 inhibitor site; inhibition site 357808010649 active site 357808010650 dimer interface [polypeptide binding]; other site 357808010651 catalytic residue [active] 357808010652 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808010653 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808010654 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 357808010655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808010656 motif II; other site 357808010657 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 357808010658 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357808010659 Cysteine-rich domain; Region: CCG; pfam02754 357808010660 Cysteine-rich domain; Region: CCG; pfam02754 357808010661 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808010662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808010663 active site 357808010664 phosphorylation site [posttranslational modification] 357808010665 intermolecular recognition site; other site 357808010666 dimerization interface [polypeptide binding]; other site 357808010667 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808010668 DNA binding site [nucleotide binding] 357808010669 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 357808010670 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 357808010671 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 357808010672 PBP superfamily domain; Region: PBP_like_2; cl17296 357808010673 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 357808010674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808010675 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808010676 dimerization interface [polypeptide binding]; other site 357808010677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808010678 dimer interface [polypeptide binding]; other site 357808010679 phosphorylation site [posttranslational modification] 357808010680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808010681 ATP binding site [chemical binding]; other site 357808010682 Mg2+ binding site [ion binding]; other site 357808010683 G-X-G motif; other site 357808010684 Response regulator receiver domain; Region: Response_reg; pfam00072 357808010685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808010686 active site 357808010687 phosphorylation site [posttranslational modification] 357808010688 intermolecular recognition site; other site 357808010689 dimerization interface [polypeptide binding]; other site 357808010690 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 357808010691 beta-galactosidase; Region: BGL; TIGR03356 357808010692 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808010693 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808010694 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 357808010695 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 357808010696 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 357808010697 putative active site [active] 357808010698 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808010699 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808010700 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 357808010701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357808010702 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357808010703 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357808010704 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357808010705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808010706 dimer interface [polypeptide binding]; other site 357808010707 conserved gate region; other site 357808010708 putative PBP binding loops; other site 357808010709 ABC-ATPase subunit interface; other site 357808010710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808010711 dimer interface [polypeptide binding]; other site 357808010712 conserved gate region; other site 357808010713 putative PBP binding loops; other site 357808010714 ABC-ATPase subunit interface; other site 357808010715 PQQ-like domain; Region: PQQ_2; pfam13360 357808010716 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 357808010717 active site 357808010718 Trp docking motif [polypeptide binding]; other site 357808010719 PQQ-like domain; Region: PQQ_2; pfam13360 357808010720 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357808010721 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357808010722 DNA binding site [nucleotide binding] 357808010723 domain linker motif; other site 357808010724 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 357808010725 putative dimerization interface [polypeptide binding]; other site 357808010726 putative ligand binding site [chemical binding]; other site 357808010727 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 357808010728 DNA binding site [nucleotide binding] 357808010729 active site 357808010730 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808010731 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808010732 active site 357808010733 ATP binding site [chemical binding]; other site 357808010734 substrate binding site [chemical binding]; other site 357808010735 activation loop (A-loop); other site 357808010736 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 357808010737 Transglycosylase; Region: Transgly; pfam00912 357808010738 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 357808010739 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 357808010740 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 357808010741 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 357808010742 Protein of unknown function (DUF433); Region: DUF433; pfam04255 357808010743 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 357808010744 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357808010745 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 357808010746 active site 357808010747 metal binding site [ion binding]; metal-binding site 357808010748 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808010749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808010750 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808010751 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 357808010752 FOG: CBS domain [General function prediction only]; Region: COG0517 357808010753 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 357808010754 Chain length determinant protein; Region: Wzz; cl15801 357808010755 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 357808010756 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357808010757 HlyD family secretion protein; Region: HlyD_3; pfam13437 357808010758 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 357808010759 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 357808010760 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808010761 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808010762 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 357808010763 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808010764 putative ADP-binding pocket [chemical binding]; other site 357808010765 Bacterial sugar transferase; Region: Bac_transf; pfam02397 357808010766 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 357808010767 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 357808010768 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 357808010769 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 357808010770 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357808010771 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 357808010772 acyl-activating enzyme (AAE) consensus motif; other site 357808010773 putative AMP binding site [chemical binding]; other site 357808010774 putative active site [active] 357808010775 putative CoA binding site [chemical binding]; other site 357808010776 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 357808010777 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 357808010778 active site 357808010779 dimer interface [polypeptide binding]; other site 357808010780 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 357808010781 Ligand Binding Site [chemical binding]; other site 357808010782 Molecular Tunnel; other site 357808010783 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 357808010784 NAD synthetase; Reviewed; Region: nadE; PRK00876 357808010785 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 357808010786 homodimer interface [polypeptide binding]; other site 357808010787 NAD binding pocket [chemical binding]; other site 357808010788 ATP binding pocket [chemical binding]; other site 357808010789 Mg binding site [ion binding]; other site 357808010790 active-site loop [active] 357808010791 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 357808010792 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 357808010793 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 357808010794 inhibitor-cofactor binding pocket; inhibition site 357808010795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808010796 catalytic residue [active] 357808010797 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 357808010798 putative active site [active] 357808010799 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 357808010800 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 357808010801 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 357808010802 NAD(P) binding site [chemical binding]; other site 357808010803 homodimer interface [polypeptide binding]; other site 357808010804 substrate binding site [chemical binding]; other site 357808010805 active site 357808010806 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 357808010807 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 357808010808 NADP-binding site; other site 357808010809 homotetramer interface [polypeptide binding]; other site 357808010810 substrate binding site [chemical binding]; other site 357808010811 homodimer interface [polypeptide binding]; other site 357808010812 active site 357808010813 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 357808010814 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 357808010815 hinge; other site 357808010816 active site 357808010817 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808010818 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808010819 phosphopeptide binding site; other site 357808010820 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808010821 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808010822 DNA binding site [nucleotide binding] 357808010823 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808010824 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808010825 active site 357808010826 ATP binding site [chemical binding]; other site 357808010827 substrate binding site [chemical binding]; other site 357808010828 activation loop (A-loop); other site 357808010829 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 357808010830 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 357808010831 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808010832 ATP binding site [chemical binding]; other site 357808010833 putative Mg++ binding site [ion binding]; other site 357808010834 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808010835 nucleotide binding region [chemical binding]; other site 357808010836 ATP-binding site [chemical binding]; other site 357808010837 TRCF domain; Region: TRCF; pfam03461 357808010838 trigger factor; Provisional; Region: tig; PRK01490 357808010839 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 357808010840 Clp protease; Region: CLP_protease; pfam00574 357808010841 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 357808010842 oligomer interface [polypeptide binding]; other site 357808010843 active site residues [active] 357808010844 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 357808010845 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 357808010846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808010847 Walker A motif; other site 357808010848 ATP binding site [chemical binding]; other site 357808010849 Walker B motif; other site 357808010850 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 357808010851 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 357808010852 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357808010853 Beta-lactamase; Region: Beta-lactamase; pfam00144 357808010854 CAAX protease self-immunity; Region: Abi; pfam02517 357808010855 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 357808010856 UbiA prenyltransferase family; Region: UbiA; pfam01040 357808010857 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 357808010858 DNA-binding site [nucleotide binding]; DNA binding site 357808010859 RNA-binding motif; other site 357808010860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808010861 binding surface 357808010862 TPR motif; other site 357808010863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808010864 TPR motif; other site 357808010865 binding surface 357808010866 Tetratricopeptide repeat; Region: TPR_16; pfam13432 357808010867 AAA ATPase domain; Region: AAA_16; pfam13191 357808010868 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 357808010869 Ligand Binding Site [chemical binding]; other site 357808010870 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 357808010871 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 357808010872 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357808010873 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 357808010874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808010875 motif II; other site 357808010876 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 357808010877 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 357808010878 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 357808010879 putative dimer interface [polypeptide binding]; other site 357808010880 [2Fe-2S] cluster binding site [ion binding]; other site 357808010881 NADH dehydrogenase subunit D; Validated; Region: PRK06075 357808010882 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 357808010883 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 357808010884 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 357808010885 NADH dehydrogenase subunit B; Validated; Region: PRK06411 357808010886 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 357808010887 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 357808010888 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 357808010889 DNA binding site [nucleotide binding] 357808010890 active site 357808010891 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357808010892 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357808010893 Probable Catalytic site; other site 357808010894 metal-binding site 357808010895 Septum formation initiator; Region: DivIC; pfam04977 357808010896 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 357808010897 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 357808010898 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 357808010899 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 357808010900 active site clefts [active] 357808010901 zinc binding site [ion binding]; other site 357808010902 dimer interface [polypeptide binding]; other site 357808010903 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 357808010904 Uncharacterized conserved protein [Function unknown]; Region: COG2361 357808010905 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357808010906 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357808010907 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 357808010908 DNA methylase; Region: N6_N4_Mtase; cl17433 357808010909 Methyltransferase domain; Region: Methyltransf_26; pfam13659 357808010910 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 357808010911 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 357808010912 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 357808010913 carboxyltransferase (CT) interaction site; other site 357808010914 biotinylation site [posttranslational modification]; other site 357808010915 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 357808010916 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 357808010917 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 357808010918 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357808010919 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 357808010920 substrate binding site [chemical binding]; other site 357808010921 ATP binding site [chemical binding]; other site 357808010922 Bacterial PH domain; Region: DUF304; pfam03703 357808010923 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 357808010924 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 357808010925 ligand binding site; other site 357808010926 oligomer interface; other site 357808010927 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 357808010928 dimer interface [polypeptide binding]; other site 357808010929 N-terminal domain interface [polypeptide binding]; other site 357808010930 sulfate 1 binding site; other site 357808010931 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 357808010932 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 357808010933 ligand binding site; other site 357808010934 oligomer interface; other site 357808010935 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 357808010936 dimer interface [polypeptide binding]; other site 357808010937 N-terminal domain interface [polypeptide binding]; other site 357808010938 sulfate 1 binding site; other site 357808010939 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 357808010940 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 357808010941 active site 357808010942 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 357808010943 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 357808010944 ATP binding site [chemical binding]; other site 357808010945 Mg++ binding site [ion binding]; other site 357808010946 motif III; other site 357808010947 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808010948 nucleotide binding region [chemical binding]; other site 357808010949 ATP-binding site [chemical binding]; other site 357808010950 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808010951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808010952 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808010953 malate dehydrogenase; Provisional; Region: PRK13529 357808010954 Malic enzyme, N-terminal domain; Region: malic; pfam00390 357808010955 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 357808010956 NAD(P) binding site [chemical binding]; other site 357808010957 excinuclease ABC subunit B; Provisional; Region: PRK05298 357808010958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808010959 nucleotide binding region [chemical binding]; other site 357808010960 ATP-binding site [chemical binding]; other site 357808010961 Ultra-violet resistance protein B; Region: UvrB; pfam12344 357808010962 MutS domain I; Region: MutS_I; pfam01624 357808010963 MutS domain II; Region: MutS_II; pfam05188 357808010964 MutS domain III; Region: MutS_III; pfam05192 357808010965 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 357808010966 MutS domain III; Region: MutS_III; pfam05192 357808010967 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 357808010968 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 357808010969 Walker A/P-loop; other site 357808010970 ATP binding site [chemical binding]; other site 357808010971 Q-loop/lid; other site 357808010972 ABC transporter signature motif; other site 357808010973 Walker B; other site 357808010974 D-loop; other site 357808010975 H-loop/switch region; other site 357808010976 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 357808010977 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 357808010978 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 357808010979 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 357808010980 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808010981 putative active site [active] 357808010982 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808010983 putative active site [active] 357808010984 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808010985 putative active site [active] 357808010986 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 357808010987 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 357808010988 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 357808010989 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357808010990 protein binding site [polypeptide binding]; other site 357808010991 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 357808010992 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 357808010993 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 357808010994 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 357808010995 polyphosphate kinase; Provisional; Region: PRK05443 357808010996 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 357808010997 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 357808010998 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 357808010999 putative domain interface [polypeptide binding]; other site 357808011000 putative active site [active] 357808011001 catalytic site [active] 357808011002 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 357808011003 putative domain interface [polypeptide binding]; other site 357808011004 putative active site [active] 357808011005 catalytic site [active] 357808011006 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 357808011007 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 357808011008 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 357808011009 trimer interface [polypeptide binding]; other site 357808011010 active site 357808011011 substrate binding site [chemical binding]; other site 357808011012 CoA binding site [chemical binding]; other site 357808011013 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 357808011014 active site 357808011015 HEAT repeats; Region: HEAT_2; pfam13646 357808011016 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 357808011017 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352 357808011018 active site 357808011019 catalytic site [active] 357808011020 D-mannonate oxidoreductase; Provisional; Region: PRK08277 357808011021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808011022 NAD(P) binding site [chemical binding]; other site 357808011023 active site 357808011024 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357808011025 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357808011026 ligand binding site [chemical binding]; other site 357808011027 flexible hinge region; other site 357808011028 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 357808011029 active site 357808011030 catalytic site [active] 357808011031 Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277 357808011032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808011033 FeS/SAM binding site; other site 357808011034 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 357808011035 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 357808011036 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 357808011037 Amidohydrolase; Region: Amidohydro_2; pfam04909 357808011038 Phosphotransferase enzyme family; Region: APH; pfam01636 357808011039 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 357808011040 Uncharacterized conserved protein [Function unknown]; Region: COG1543 357808011041 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 357808011042 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 357808011043 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 357808011044 active site residue [active] 357808011045 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808011046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357808011047 dimerization interface [polypeptide binding]; other site 357808011048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808011049 dimer interface [polypeptide binding]; other site 357808011050 phosphorylation site [posttranslational modification] 357808011051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808011052 ATP binding site [chemical binding]; other site 357808011053 Mg2+ binding site [ion binding]; other site 357808011054 G-X-G motif; other site 357808011055 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808011056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808011057 active site 357808011058 phosphorylation site [posttranslational modification] 357808011059 intermolecular recognition site; other site 357808011060 dimerization interface [polypeptide binding]; other site 357808011061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808011062 DNA binding site [nucleotide binding] 357808011063 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 357808011064 PAS domain; Region: PAS_9; pfam13426 357808011065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808011066 PAS domain; Region: PAS_9; pfam13426 357808011067 putative active site [active] 357808011068 heme pocket [chemical binding]; other site 357808011069 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357808011070 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357808011071 metal binding site [ion binding]; metal-binding site 357808011072 active site 357808011073 I-site; other site 357808011074 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357808011075 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 357808011076 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 357808011077 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357808011078 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357808011079 Walker A/P-loop; other site 357808011080 ATP binding site [chemical binding]; other site 357808011081 Q-loop/lid; other site 357808011082 ABC transporter signature motif; other site 357808011083 Walker B; other site 357808011084 D-loop; other site 357808011085 H-loop/switch region; other site 357808011086 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 357808011087 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 357808011088 active site 357808011089 tetramer interface [polypeptide binding]; other site 357808011090 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357808011091 active site 357808011092 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 357808011093 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 357808011094 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 357808011095 NAD(P) binding site [chemical binding]; other site 357808011096 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808011097 putative active site [active] 357808011098 CAAX protease self-immunity; Region: Abi; pfam02517 357808011099 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 357808011100 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 357808011101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808011102 Walker A motif; other site 357808011103 ATP binding site [chemical binding]; other site 357808011104 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 357808011105 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 357808011106 NusA N-terminal domain; Region: NusA_N; pfam08529 357808011107 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 357808011108 RNA binding site [nucleotide binding]; other site 357808011109 homodimer interface [polypeptide binding]; other site 357808011110 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 357808011111 G-X-X-G motif; other site 357808011112 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 357808011113 G-X-X-G motif; other site 357808011114 Protein of unknown function (DUF448); Region: DUF448; pfam04296 357808011115 putative RNA binding cleft [nucleotide binding]; other site 357808011116 translation initiation factor IF-2; Region: IF-2; TIGR00487 357808011117 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 357808011118 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 357808011119 G1 box; other site 357808011120 putative GEF interaction site [polypeptide binding]; other site 357808011121 GTP/Mg2+ binding site [chemical binding]; other site 357808011122 Switch I region; other site 357808011123 G2 box; other site 357808011124 G3 box; other site 357808011125 Switch II region; other site 357808011126 G4 box; other site 357808011127 G5 box; other site 357808011128 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 357808011129 Translation-initiation factor 2; Region: IF-2; pfam11987 357808011130 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 357808011131 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 357808011132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808011133 S-adenosylmethionine binding site [chemical binding]; other site 357808011134 DHH family; Region: DHH; pfam01368 357808011135 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 357808011136 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 357808011137 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 357808011138 RNA binding site [nucleotide binding]; other site 357808011139 active site 357808011140 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 357808011141 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 357808011142 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 357808011143 active site 357808011144 Riboflavin kinase; Region: Flavokinase; pfam01687 357808011145 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357808011146 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357808011147 FtsX-like permease family; Region: FtsX; pfam02687 357808011148 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 357808011149 Ligand binding site; other site 357808011150 Putative Catalytic site; other site 357808011151 DXD motif; other site 357808011152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357808011153 Histidine kinase; Region: HisKA_3; pfam07730 357808011154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808011155 ATP binding site [chemical binding]; other site 357808011156 Mg2+ binding site [ion binding]; other site 357808011157 G-X-G motif; other site 357808011158 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 357808011159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 357808011160 motif II; other site 357808011161 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 357808011162 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 357808011163 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 357808011164 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 357808011165 anti sigma factor interaction site; other site 357808011166 regulatory phosphorylation site [posttranslational modification]; other site 357808011167 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 357808011168 DXD motif; other site 357808011169 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357808011170 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 357808011171 Response regulator receiver domain; Region: Response_reg; pfam00072 357808011172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808011173 active site 357808011174 phosphorylation site [posttranslational modification] 357808011175 intermolecular recognition site; other site 357808011176 dimerization interface [polypeptide binding]; other site 357808011177 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 357808011178 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 357808011179 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808011180 GAF domain; Region: GAF; pfam01590 357808011181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808011182 PAS domain; Region: PAS_9; pfam13426 357808011183 putative active site [active] 357808011184 heme pocket [chemical binding]; other site 357808011185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808011186 PAS fold; Region: PAS_3; pfam08447 357808011187 putative active site [active] 357808011188 heme pocket [chemical binding]; other site 357808011189 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357808011190 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808011191 putative active site [active] 357808011192 heme pocket [chemical binding]; other site 357808011193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808011194 dimer interface [polypeptide binding]; other site 357808011195 phosphorylation site [posttranslational modification] 357808011196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808011197 ATP binding site [chemical binding]; other site 357808011198 Mg2+ binding site [ion binding]; other site 357808011199 G-X-G motif; other site 357808011200 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14604 357808011201 RuvA N terminal domain; Region: RuvA_N; pfam01330 357808011202 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 357808011203 nudix motif; other site 357808011204 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 357808011205 metal-binding site [ion binding] 357808011206 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 357808011207 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 357808011208 metal-binding site [ion binding] 357808011209 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357808011210 Soluble P-type ATPase [General function prediction only]; Region: COG4087 357808011211 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357808011212 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357808011213 active site 357808011214 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 357808011215 cleavage site 357808011216 active site 357808011217 substrate binding sites [chemical binding]; other site 357808011218 cell division protein MraZ; Reviewed; Region: PRK00326 357808011219 MraZ protein; Region: MraZ; pfam02381 357808011220 MraZ protein; Region: MraZ; pfam02381 357808011221 MraW methylase family; Region: Methyltransf_5; pfam01795 357808011222 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 357808011223 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 357808011224 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357808011225 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357808011226 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 357808011227 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 357808011228 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357808011229 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 357808011230 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 357808011231 Mg++ binding site [ion binding]; other site 357808011232 putative catalytic motif [active] 357808011233 putative substrate binding site [chemical binding]; other site 357808011234 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 357808011235 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357808011236 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357808011237 Rhomboid family; Region: Rhomboid; pfam01694 357808011238 cell division protein FtsW; Region: ftsW; TIGR02614 357808011239 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 357808011240 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 357808011241 active site 357808011242 homodimer interface [polypeptide binding]; other site 357808011243 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 357808011244 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357808011245 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357808011246 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808011247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808011248 TPR motif; other site 357808011249 binding surface 357808011250 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808011251 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14649 357808011252 FAD binding domain; Region: FAD_binding_4; pfam01565 357808011253 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 357808011254 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 357808011255 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 357808011256 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 357808011257 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 357808011258 Cell division protein FtsQ; Region: FtsQ; pfam03799 357808011259 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 357808011260 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 357808011261 nucleotide binding site [chemical binding]; other site 357808011262 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 357808011263 Cell division protein FtsA; Region: FtsA; pfam14450 357808011264 cell division protein FtsZ; Validated; Region: PRK09330 357808011265 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 357808011266 nucleotide binding site [chemical binding]; other site 357808011267 SulA interaction site; other site 357808011268 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 357808011269 active site 357808011270 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 357808011271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808011272 putative substrate translocation pore; other site 357808011273 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 357808011274 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 357808011275 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808011276 PAS domain; Region: PAS_9; pfam13426 357808011277 putative active site [active] 357808011278 heme pocket [chemical binding]; other site 357808011279 PAS domain S-box; Region: sensory_box; TIGR00229 357808011280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808011281 putative active site [active] 357808011282 heme pocket [chemical binding]; other site 357808011283 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808011284 Integral membrane protein DUF95; Region: DUF95; pfam01944 357808011285 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 357808011286 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 357808011287 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808011288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808011289 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808011290 thymidine kinase; Provisional; Region: PRK04296 357808011291 CoA binding domain; Region: CoA_binding; cl17356 357808011292 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 357808011293 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 357808011294 active site 357808011295 Zn binding site [ion binding]; other site 357808011296 Predicted membrane protein [Function unknown]; Region: COG2261 357808011297 recombination factor protein RarA; Reviewed; Region: PRK13342 357808011298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808011299 Walker A motif; other site 357808011300 ATP binding site [chemical binding]; other site 357808011301 Walker B motif; other site 357808011302 arginine finger; other site 357808011303 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 357808011304 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 357808011305 hydroxyglutarate oxidase; Provisional; Region: PRK11728 357808011306 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 357808011307 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 357808011308 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808011309 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808011310 DNA binding residues [nucleotide binding] 357808011311 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 357808011312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808011313 S-adenosylmethionine binding site [chemical binding]; other site 357808011314 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 357808011315 Peptidase family M50; Region: Peptidase_M50; pfam02163 357808011316 active site 357808011317 putative substrate binding region [chemical binding]; other site 357808011318 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 357808011319 triosephosphate isomerase; Provisional; Region: PRK14565 357808011320 substrate binding site [chemical binding]; other site 357808011321 dimer interface [polypeptide binding]; other site 357808011322 catalytic triad [active] 357808011323 Response regulator receiver domain; Region: Response_reg; pfam00072 357808011324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808011325 active site 357808011326 phosphorylation site [posttranslational modification] 357808011327 intermolecular recognition site; other site 357808011328 dimerization interface [polypeptide binding]; other site 357808011329 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 357808011330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808011331 Walker A motif; other site 357808011332 ATP binding site [chemical binding]; other site 357808011333 Walker B motif; other site 357808011334 arginine finger; other site 357808011335 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 357808011336 PAS domain S-box; Region: sensory_box; TIGR00229 357808011337 PAS domain; Region: PAS; smart00091 357808011338 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808011339 GAF domain; Region: GAF_3; pfam13492 357808011340 GAF domain; Region: GAF_2; pfam13185 357808011341 GAF domain; Region: GAF_3; pfam13492 357808011342 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808011343 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808011344 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357808011345 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357808011346 metal binding site [ion binding]; metal-binding site 357808011347 active site 357808011348 I-site; other site 357808011349 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357808011350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808011351 putative active site [active] 357808011352 heme pocket [chemical binding]; other site 357808011353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808011354 dimer interface [polypeptide binding]; other site 357808011355 phosphorylation site [posttranslational modification] 357808011356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808011357 ATP binding site [chemical binding]; other site 357808011358 Mg2+ binding site [ion binding]; other site 357808011359 G-X-G motif; other site 357808011360 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808011361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808011362 active site 357808011363 phosphorylation site [posttranslational modification] 357808011364 intermolecular recognition site; other site 357808011365 dimerization interface [polypeptide binding]; other site 357808011366 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808011367 DNA binding site [nucleotide binding] 357808011368 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 357808011369 galactokinase; Provisional; Region: PRK05101 357808011370 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 357808011371 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 357808011372 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 357808011373 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 357808011374 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 357808011375 enoyl-CoA hydratase; Provisional; Region: PRK05995 357808011376 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357808011377 substrate binding site [chemical binding]; other site 357808011378 oxyanion hole (OAH) forming residues; other site 357808011379 trimer interface [polypeptide binding]; other site 357808011380 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 357808011381 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 357808011382 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 357808011383 ADP-glucose phosphorylase; Region: PLN02643 357808011384 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 357808011385 nucleotide binding site/active site [active] 357808011386 HIT family signature motif; other site 357808011387 catalytic residue [active] 357808011388 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357808011389 HD domain; Region: HD_4; pfam13328 357808011390 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357808011391 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357808011392 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357808011393 Walker A/P-loop; other site 357808011394 ATP binding site [chemical binding]; other site 357808011395 Q-loop/lid; other site 357808011396 ABC transporter signature motif; other site 357808011397 Walker B; other site 357808011398 D-loop; other site 357808011399 H-loop/switch region; other site 357808011400 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808011401 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808011402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357808011403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357808011404 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 357808011405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808011406 active site 357808011407 motif I; other site 357808011408 motif II; other site 357808011409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808011410 Coenzyme A binding pocket [chemical binding]; other site 357808011411 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357808011412 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 357808011413 TPR repeat; Region: TPR_11; pfam13414 357808011414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808011415 binding surface 357808011416 TPR motif; other site 357808011417 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357808011418 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 357808011419 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357808011420 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808011421 active site 357808011422 NTP binding site [chemical binding]; other site 357808011423 metal binding triad [ion binding]; metal-binding site 357808011424 antibiotic binding site [chemical binding]; other site 357808011425 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 357808011426 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808011427 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808011428 active site 357808011429 ATP binding site [chemical binding]; other site 357808011430 substrate binding site [chemical binding]; other site 357808011431 activation loop (A-loop); other site 357808011432 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 357808011433 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808011434 active site 357808011435 NTP binding site [chemical binding]; other site 357808011436 metal binding triad [ion binding]; metal-binding site 357808011437 antibiotic binding site [chemical binding]; other site 357808011438 HEPN domain; Region: HEPN; pfam05168 357808011439 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 357808011440 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357808011441 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357808011442 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 357808011443 Nitrogen regulatory protein P-II; Region: P-II; cl00412 357808011444 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808011445 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808011446 DNA binding site [nucleotide binding] 357808011447 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 357808011448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 357808011449 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 357808011450 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 357808011451 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357808011452 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 357808011453 SPFH domain / Band 7 family; Region: Band_7; pfam01145 357808011454 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 357808011455 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 357808011456 FAD binding domain; Region: FAD_binding_4; pfam01565 357808011457 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 357808011458 Cysteine-rich domain; Region: CCG; pfam02754 357808011459 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 357808011460 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 357808011461 acyl-activating enzyme (AAE) consensus motif; other site 357808011462 active site 357808011463 AMP binding site [chemical binding]; other site 357808011464 CoA binding site [chemical binding]; other site 357808011465 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 357808011466 CoA-transferase family III; Region: CoA_transf_3; pfam02515 357808011467 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 357808011468 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357808011469 RNA binding surface [nucleotide binding]; other site 357808011470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808011471 S-adenosylmethionine binding site [chemical binding]; other site 357808011472 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 357808011473 active site 357808011474 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 357808011475 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 357808011476 active site 357808011477 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 357808011478 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 357808011479 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 357808011480 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 357808011481 dimer interface [polypeptide binding]; other site 357808011482 active site 357808011483 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357808011484 substrate binding site [chemical binding]; other site 357808011485 catalytic residue [active] 357808011486 OsmC-like protein; Region: OsmC; pfam02566 357808011487 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 357808011488 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 357808011489 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 357808011490 inhibitor-cofactor binding pocket; inhibition site 357808011491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808011492 catalytic residue [active] 357808011493 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357808011494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808011495 NAD(P) binding site [chemical binding]; other site 357808011496 active site 357808011497 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 357808011498 Ligand binding site; other site 357808011499 Putative Catalytic site; other site 357808011500 DXD motif; other site 357808011501 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 357808011502 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 357808011503 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 357808011504 histidinol-phosphate aminotransferase; Provisional; Region: PLN03026 357808011505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357808011506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808011507 homodimer interface [polypeptide binding]; other site 357808011508 catalytic residue [active] 357808011509 Domain of unknown function (DUF368); Region: DUF368; pfam04018 357808011510 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808011511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808011512 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808011513 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 357808011514 HemN C-terminal domain; Region: HemN_C; pfam06969 357808011515 CHASE4 domain; Region: CHASE4; pfam05228 357808011516 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 357808011517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808011518 dimerization interface [polypeptide binding]; other site 357808011519 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357808011520 PAS domain; Region: PAS_8; pfam13188 357808011521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808011522 dimer interface [polypeptide binding]; other site 357808011523 phosphorylation site [posttranslational modification] 357808011524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808011525 ATP binding site [chemical binding]; other site 357808011526 Mg2+ binding site [ion binding]; other site 357808011527 G-X-G motif; other site 357808011528 Response regulator receiver domain; Region: Response_reg; pfam00072 357808011529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808011530 active site 357808011531 phosphorylation site [posttranslational modification] 357808011532 intermolecular recognition site; other site 357808011533 dimerization interface [polypeptide binding]; other site 357808011534 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357808011535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808011536 active site 357808011537 phosphorylation site [posttranslational modification] 357808011538 intermolecular recognition site; other site 357808011539 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357808011540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808011541 active site 357808011542 phosphorylation site [posttranslational modification] 357808011543 intermolecular recognition site; other site 357808011544 dimerization interface [polypeptide binding]; other site 357808011545 Response regulator receiver domain; Region: Response_reg; pfam00072 357808011546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808011547 active site 357808011548 phosphorylation site [posttranslational modification] 357808011549 intermolecular recognition site; other site 357808011550 dimerization interface [polypeptide binding]; other site 357808011551 PAS domain; Region: PAS; smart00091 357808011552 PAS fold; Region: PAS_4; pfam08448 357808011553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808011554 PAS fold; Region: PAS_3; pfam08447 357808011555 putative active site [active] 357808011556 heme pocket [chemical binding]; other site 357808011557 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357808011558 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357808011559 metal binding site [ion binding]; metal-binding site 357808011560 active site 357808011561 I-site; other site 357808011562 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357808011563 Homeodomain-like domain; Region: HTH_23; pfam13384 357808011564 Winged helix-turn helix; Region: HTH_29; pfam13551 357808011565 Winged helix-turn helix; Region: HTH_33; pfam13592 357808011566 DDE superfamily endonuclease; Region: DDE_3; pfam13358 357808011567 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 357808011568 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808011569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808011570 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808011571 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 357808011572 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 357808011573 active site 357808011574 dimer interface [polypeptide binding]; other site 357808011575 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 357808011576 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 357808011577 active site 357808011578 Substrate binding site; other site 357808011579 Mg++ binding site; other site 357808011580 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 357808011581 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 357808011582 dimer interaction site [polypeptide binding]; other site 357808011583 substrate-binding tunnel; other site 357808011584 active site 357808011585 catalytic site [active] 357808011586 substrate binding site [chemical binding]; other site 357808011587 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 357808011588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808011589 putative substrate translocation pore; other site 357808011590 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357808011591 Protein of unknown function DUF45; Region: DUF45; cl00636 357808011592 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808011593 Double zinc ribbon; Region: DZR; pfam12773 357808011594 Double zinc ribbon; Region: DZR; pfam12773 357808011595 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 357808011596 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 357808011597 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808011598 active site 357808011599 ATP binding site [chemical binding]; other site 357808011600 substrate binding site [chemical binding]; other site 357808011601 activation loop (A-loop); other site 357808011602 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 357808011603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808011604 S-adenosylmethionine binding site [chemical binding]; other site 357808011605 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808011606 Double zinc ribbon; Region: DZR; pfam12773 357808011607 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 357808011608 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357808011609 active site 357808011610 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 357808011611 catalytic tetrad [active] 357808011612 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808011613 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808011614 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808011615 YtkA-like; Region: YtkA; pfam13115 357808011616 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 357808011617 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 357808011618 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 357808011619 Ligand binding site; other site 357808011620 Putative Catalytic site; other site 357808011621 DXD motif; other site 357808011622 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 357808011623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808011624 motif II; other site 357808011625 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 357808011626 oligomeric interface; other site 357808011627 putative active site [active] 357808011628 homodimer interface [polypeptide binding]; other site 357808011629 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 357808011630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808011631 TPR repeat; Region: TPR_11; pfam13414 357808011632 TPR motif; other site 357808011633 CHAT domain; Region: CHAT; pfam12770 357808011634 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 357808011635 FOG: WD40 repeat [General function prediction only]; Region: COG2319 357808011636 structural tetrad; other site 357808011637 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 357808011638 putative acyltransferase; Provisional; Region: PRK05790 357808011639 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 357808011640 dimer interface [polypeptide binding]; other site 357808011641 active site 357808011642 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 357808011643 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 357808011644 heme-binding site [chemical binding]; other site 357808011645 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 357808011646 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 357808011647 G1 box; other site 357808011648 GTP/Mg2+ binding site [chemical binding]; other site 357808011649 G2 box; other site 357808011650 Switch I region; other site 357808011651 G3 box; other site 357808011652 Switch II region; other site 357808011653 G4 box; other site 357808011654 G5 box; other site 357808011655 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 357808011656 MPT binding site; other site 357808011657 trimer interface [polypeptide binding]; other site 357808011658 Haemolytic domain; Region: Haemolytic; pfam01809 357808011659 HEPN domain; Region: HEPN; pfam05168 357808011660 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808011661 active site 357808011662 NTP binding site [chemical binding]; other site 357808011663 metal binding triad [ion binding]; metal-binding site 357808011664 antibiotic binding site [chemical binding]; other site 357808011665 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 357808011666 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 357808011667 putative active site [active] 357808011668 substrate binding site [chemical binding]; other site 357808011669 putative cosubstrate binding site; other site 357808011670 catalytic site [active] 357808011671 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 357808011672 substrate binding site [chemical binding]; other site 357808011673 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 357808011674 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 357808011675 putative NAD(P) binding site [chemical binding]; other site 357808011676 catalytic Zn binding site [ion binding]; other site 357808011677 structural Zn binding site [ion binding]; other site 357808011678 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 357808011679 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357808011680 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 357808011681 substrate binding site [chemical binding]; other site 357808011682 ATP binding site [chemical binding]; other site 357808011683 Response regulator receiver domain; Region: Response_reg; pfam00072 357808011684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808011685 active site 357808011686 phosphorylation site [posttranslational modification] 357808011687 intermolecular recognition site; other site 357808011688 dimerization interface [polypeptide binding]; other site 357808011689 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357808011690 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357808011691 metal binding site [ion binding]; metal-binding site 357808011692 active site 357808011693 I-site; other site 357808011694 Response regulator receiver domain; Region: Response_reg; pfam00072 357808011695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808011696 binding surface 357808011697 TPR motif; other site 357808011698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808011699 binding surface 357808011700 TPR motif; other site 357808011701 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 357808011702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808011703 TPR motif; other site 357808011704 binding surface 357808011705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808011706 binding surface 357808011707 TPR motif; other site 357808011708 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 357808011709 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 357808011710 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357808011711 inhibitor-cofactor binding pocket; inhibition site 357808011712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808011713 catalytic residue [active] 357808011714 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 357808011715 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 357808011716 NADP-binding site; other site 357808011717 homotetramer interface [polypeptide binding]; other site 357808011718 substrate binding site [chemical binding]; other site 357808011719 homodimer interface [polypeptide binding]; other site 357808011720 active site 357808011721 Protein of unknown function DUF262; Region: DUF262; pfam03235 357808011722 Uncharacterized conserved protein [Function unknown]; Region: COG1479 357808011723 Protein of unknown function DUF262; Region: DUF262; pfam03235 357808011724 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 357808011725 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 357808011726 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 357808011727 CoA-ligase; Region: Ligase_CoA; pfam00549 357808011728 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 357808011729 PspC domain; Region: PspC; pfam04024 357808011730 Thiamine pyrophosphokinase; Region: TPK; cd07995 357808011731 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 357808011732 active site 357808011733 dimerization interface [polypeptide binding]; other site 357808011734 thiamine binding site [chemical binding]; other site 357808011735 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 357808011736 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 357808011737 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 357808011738 Double zinc ribbon; Region: DZR; pfam12773 357808011739 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808011740 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808011741 phosphopeptide binding site; other site 357808011742 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808011743 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808011744 phosphopeptide binding site; other site 357808011745 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 357808011746 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357808011747 Walker A/P-loop; other site 357808011748 ATP binding site [chemical binding]; other site 357808011749 Q-loop/lid; other site 357808011750 ABC transporter signature motif; other site 357808011751 Walker B; other site 357808011752 D-loop; other site 357808011753 H-loop/switch region; other site 357808011754 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357808011755 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 357808011756 Double zinc ribbon; Region: DZR; pfam12773 357808011757 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808011758 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357808011759 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357808011760 phosphopeptide binding site; other site 357808011761 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 357808011762 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 357808011763 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 357808011764 hypothetical protein; Provisional; Region: PRK11622 357808011765 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 357808011766 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 357808011767 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 357808011768 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 357808011769 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 357808011770 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 357808011771 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 357808011772 NAD binding site [chemical binding]; other site 357808011773 ligand binding site [chemical binding]; other site 357808011774 catalytic site [active] 357808011775 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 357808011776 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 357808011777 AAA ATPase domain; Region: AAA_16; pfam13191 357808011778 Archaeal ATPase; Region: Arch_ATPase; pfam01637 357808011779 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 357808011780 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 357808011781 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 357808011782 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 357808011783 catalytic residues [active] 357808011784 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 357808011785 H+ Antiporter protein; Region: 2A0121; TIGR00900 357808011786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808011787 putative substrate translocation pore; other site 357808011788 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 357808011789 active site 357808011790 catalytic triad [active] 357808011791 oxyanion hole [active] 357808011792 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 357808011793 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 357808011794 inhibitor-cofactor binding pocket; inhibition site 357808011795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808011796 catalytic residue [active] 357808011797 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 357808011798 putative ligand binding pocket/active site [active] 357808011799 putative metal binding site [ion binding]; other site 357808011800 Bacterial SH3 domain; Region: SH3_3; pfam08239 357808011801 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 357808011802 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607 357808011803 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 357808011804 active site residue [active] 357808011805 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 357808011806 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 357808011807 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357808011808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357808011809 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357808011810 dimerization interface [polypeptide binding]; other site 357808011811 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 357808011812 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 357808011813 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357808011814 substrate binding site [chemical binding]; other site 357808011815 ATP binding site [chemical binding]; other site 357808011816 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 357808011817 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 357808011818 G-X-X-G motif; other site 357808011819 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 357808011820 RxxxH motif; other site 357808011821 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 357808011822 Ribonuclease P; Region: Ribonuclease_P; pfam00825 357808011823 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 357808011824 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 357808011825 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 357808011826 RNA binding site [nucleotide binding]; other site 357808011827 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 357808011828 RNA binding site [nucleotide binding]; other site 357808011829 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 357808011830 RNA binding site [nucleotide binding]; other site 357808011831 HEAT repeats; Region: HEAT_2; pfam13646 357808011832 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 357808011833 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 357808011834 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 357808011835 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 357808011836 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 357808011837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808011838 active site 357808011839 motif I; other site 357808011840 motif II; other site 357808011841 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 357808011842 active site 357808011843 Zn binding site [ion binding]; other site 357808011844 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 357808011845 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 357808011846 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357808011847 ATP binding site [chemical binding]; other site 357808011848 putative Mg++ binding site [ion binding]; other site 357808011849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357808011850 nucleotide binding region [chemical binding]; other site 357808011851 ATP-binding site [chemical binding]; other site 357808011852 Thioredoxin; Region: Thioredoxin_4; pfam13462 357808011853 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 357808011854 protein-export membrane protein SecD; Region: secD; TIGR01129 357808011855 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 357808011856 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 357808011857 Protein export membrane protein; Region: SecD_SecF; cl14618 357808011858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808011859 S-adenosylmethionine binding site [chemical binding]; other site 357808011860 UGMP family protein; Validated; Region: PRK09604 357808011861 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 357808011862 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 357808011863 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 357808011864 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 357808011865 FeoA domain; Region: FeoA; pfam04023 357808011866 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 357808011867 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 357808011868 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 357808011869 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 357808011870 active site 357808011871 catalytic residues [active] 357808011872 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 357808011873 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 357808011874 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 357808011875 CARDB; Region: CARDB; pfam07705 357808011876 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 357808011877 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808011878 putative active site [active] 357808011879 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 357808011880 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 357808011881 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 357808011882 Walker A/P-loop; other site 357808011883 ATP binding site [chemical binding]; other site 357808011884 Q-loop/lid; other site 357808011885 ABC transporter signature motif; other site 357808011886 Walker B; other site 357808011887 D-loop; other site 357808011888 H-loop/switch region; other site 357808011889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808011890 dimer interface [polypeptide binding]; other site 357808011891 conserved gate region; other site 357808011892 putative PBP binding loops; other site 357808011893 ABC-ATPase subunit interface; other site 357808011894 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 357808011895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808011896 conserved gate region; other site 357808011897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808011898 putative PBP binding loops; other site 357808011899 dimer interface [polypeptide binding]; other site 357808011900 ABC-ATPase subunit interface; other site 357808011901 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 357808011902 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357808011903 substrate binding pocket [chemical binding]; other site 357808011904 membrane-bound complex binding site; other site 357808011905 hinge residues; other site 357808011906 AAA-like domain; Region: AAA_10; pfam12846 357808011907 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 357808011908 IHF dimer interface [polypeptide binding]; other site 357808011909 IHF - DNA interface [nucleotide binding]; other site 357808011910 DNA methylase; Region: N6_N4_Mtase; cl17433 357808011911 Catalytic GIY-YIG domain of type II restriction enzyme R.Cfr42I and similar proteins; Region: GIY-YIG_RE_Cfr42I; cd10453 357808011912 GIY-YIG motif/motif A; other site 357808011913 putative active site [active] 357808011914 putative metal binding site [ion binding]; other site 357808011915 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 357808011916 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 357808011917 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357808011918 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 357808011919 NodB motif; other site 357808011920 active site 357808011921 catalytic site [active] 357808011922 metal binding site [ion binding]; metal-binding site 357808011923 YcxB-like protein; Region: YcxB; pfam14317 357808011924 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357808011925 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 357808011926 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 357808011927 MutS domain III; Region: MutS_III; pfam05192 357808011928 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 357808011929 Walker A/P-loop; other site 357808011930 ATP binding site [chemical binding]; other site 357808011931 Q-loop/lid; other site 357808011932 ABC transporter signature motif; other site 357808011933 Walker B; other site 357808011934 D-loop; other site 357808011935 H-loop/switch region; other site 357808011936 Smr domain; Region: Smr; pfam01713 357808011937 CAAX protease self-immunity; Region: Abi; pfam02517 357808011938 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357808011939 dimerization interface [polypeptide binding]; other site 357808011940 putative DNA binding site [nucleotide binding]; other site 357808011941 putative Zn2+ binding site [ion binding]; other site 357808011942 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 357808011943 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357808011944 molybdopterin cofactor binding site; other site 357808011945 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 357808011946 molybdopterin cofactor binding site; other site 357808011947 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 357808011948 SWIM zinc finger; Region: SWIM; pfam04434 357808011949 MoxR-like ATPases [General function prediction only]; Region: COG0714 357808011950 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 357808011951 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 357808011952 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 357808011953 metal ion-dependent adhesion site (MIDAS); other site 357808011954 NB-ARC domain; Region: NB-ARC; pfam00931 357808011955 PQQ-like domain; Region: PQQ_2; pfam13360 357808011956 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 357808011957 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 357808011958 structural tetrad; other site 357808011959 PQQ-like domain; Region: PQQ_2; pfam13360 357808011960 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 357808011961 structural tetrad; other site 357808011962 FOG: WD40 repeat [General function prediction only]; Region: COG2319 357808011963 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 357808011964 structural tetrad; other site 357808011965 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 357808011966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808011967 Coenzyme A binding pocket [chemical binding]; other site 357808011968 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357808011969 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 357808011970 ligand binding site [chemical binding]; other site 357808011971 flexible hinge region; other site 357808011972 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 357808011973 short chain dehydrogenase; Provisional; Region: PRK06197 357808011974 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 357808011975 putative NAD(P) binding site [chemical binding]; other site 357808011976 active site 357808011977 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 357808011978 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 357808011979 DNA binding residues [nucleotide binding] 357808011980 putative dimer interface [polypeptide binding]; other site 357808011981 GAF domain; Region: GAF_2; pfam13185 357808011982 GAF domain; Region: GAF_3; pfam13492 357808011983 Bacterial PH domain; Region: DUF304; cl01348 357808011984 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 357808011985 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808011986 active site 357808011987 ATP binding site [chemical binding]; other site 357808011988 substrate binding site [chemical binding]; other site 357808011989 activation loop (A-loop); other site 357808011990 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808011991 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808011992 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357808011993 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357808011994 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 357808011995 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 357808011996 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357808011997 active site 357808011998 metal binding site [ion binding]; metal-binding site 357808011999 methionine gamma-lyase; Validated; Region: PRK07049 357808012000 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 357808012001 homodimer interface [polypeptide binding]; other site 357808012002 substrate-cofactor binding pocket; other site 357808012003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808012004 catalytic residue [active] 357808012005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 357808012006 PAS domain; Region: PAS_9; pfam13426 357808012007 putative active site [active] 357808012008 heme pocket [chemical binding]; other site 357808012009 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808012010 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808012011 PAS domain; Region: PAS_9; pfam13426 357808012012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808012013 dimer interface [polypeptide binding]; other site 357808012014 phosphorylation site [posttranslational modification] 357808012015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808012016 ATP binding site [chemical binding]; other site 357808012017 Mg2+ binding site [ion binding]; other site 357808012018 G-X-G motif; other site 357808012019 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357808012020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808012021 active site 357808012022 phosphorylation site [posttranslational modification] 357808012023 intermolecular recognition site; other site 357808012024 dimerization interface [polypeptide binding]; other site 357808012025 Response regulator receiver domain; Region: Response_reg; pfam00072 357808012026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808012027 active site 357808012028 phosphorylation site [posttranslational modification] 357808012029 intermolecular recognition site; other site 357808012030 dimerization interface [polypeptide binding]; other site 357808012031 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 357808012032 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357808012033 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 357808012034 Chain length determinant protein; Region: Wzz; pfam02706 357808012035 Chain length determinant protein; Region: Wzz; cl15801 357808012036 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808012037 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 357808012038 putative ADP-binding pocket [chemical binding]; other site 357808012039 Rubrerythrin [Energy production and conversion]; Region: COG1592 357808012040 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 357808012041 dinuclear metal binding motif [ion binding]; other site 357808012042 DinB superfamily; Region: DinB_2; pfam12867 357808012043 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 357808012044 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808012045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808012046 active site 357808012047 phosphorylation site [posttranslational modification] 357808012048 intermolecular recognition site; other site 357808012049 dimerization interface [polypeptide binding]; other site 357808012050 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808012051 DNA binding site [nucleotide binding] 357808012052 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 357808012053 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 357808012054 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 357808012055 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 357808012056 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 357808012057 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 357808012058 nucleotide binding site [chemical binding]; other site 357808012059 N-acetyl-L-glutamate binding site [chemical binding]; other site 357808012060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808012061 Coenzyme A binding pocket [chemical binding]; other site 357808012062 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 357808012063 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 357808012064 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 357808012065 catalytic site [active] 357808012066 subunit interface [polypeptide binding]; other site 357808012067 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 357808012068 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357808012069 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 357808012070 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 357808012071 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357808012072 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357808012073 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 357808012074 IMP binding site; other site 357808012075 dimer interface [polypeptide binding]; other site 357808012076 interdomain contacts; other site 357808012077 partial ornithine binding site; other site 357808012078 argininosuccinate synthase; Provisional; Region: PRK13820 357808012079 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 357808012080 ANP binding site [chemical binding]; other site 357808012081 Substrate Binding Site II [chemical binding]; other site 357808012082 Substrate Binding Site I [chemical binding]; other site 357808012083 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 357808012084 heterotetramer interface [polypeptide binding]; other site 357808012085 active site pocket [active] 357808012086 cleavage site 357808012087 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 357808012088 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 357808012089 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 357808012090 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 357808012091 glutaminase active site [active] 357808012092 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 357808012093 dimer interface [polypeptide binding]; other site 357808012094 active site 357808012095 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 357808012096 dimer interface [polypeptide binding]; other site 357808012097 active site 357808012098 Ferrochelatase; Region: Ferrochelatase; pfam00762 357808012099 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 357808012100 active site 357808012101 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 357808012102 active site 357808012103 DNA methylase; Region: N6_N4_Mtase; cl17433 357808012104 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357808012105 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 357808012106 HlyD family secretion protein; Region: HlyD_3; pfam13437 357808012107 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 357808012108 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 357808012109 Clp amino terminal domain; Region: Clp_N; pfam02861 357808012110 Clp amino terminal domain; Region: Clp_N; pfam02861 357808012111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808012112 Walker A motif; other site 357808012113 ATP binding site [chemical binding]; other site 357808012114 Walker B motif; other site 357808012115 arginine finger; other site 357808012116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808012117 Walker A motif; other site 357808012118 ATP binding site [chemical binding]; other site 357808012119 Walker B motif; other site 357808012120 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 357808012121 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 357808012122 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357808012123 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357808012124 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 357808012125 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357808012126 active site 357808012127 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357808012128 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 357808012129 active site 357808012130 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808012131 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808012132 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357808012133 active site 357808012134 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808012135 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808012136 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357808012137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808012138 NAD(P) binding site [chemical binding]; other site 357808012139 active site 357808012140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808012141 active site 357808012142 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 357808012143 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 357808012144 Substrate binding site; other site 357808012145 metal-binding site 357808012146 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 357808012147 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 357808012148 NAD binding site [chemical binding]; other site 357808012149 substrate binding site [chemical binding]; other site 357808012150 active site 357808012151 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 357808012152 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808012153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808012154 S-adenosylmethionine binding site [chemical binding]; other site 357808012155 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 357808012156 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 357808012157 Ligand binding site; other site 357808012158 Putative Catalytic site; other site 357808012159 DXD motif; other site 357808012160 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808012161 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808012162 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 357808012163 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 357808012164 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 357808012165 Ligand binding site; other site 357808012166 Putative Catalytic site; other site 357808012167 DXD motif; other site 357808012168 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 357808012169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808012170 S-adenosylmethionine binding site [chemical binding]; other site 357808012171 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 357808012172 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 357808012173 active site 357808012174 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808012175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808012176 S-adenosylmethionine binding site [chemical binding]; other site 357808012177 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 357808012178 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 357808012179 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 357808012180 active site 357808012181 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 357808012182 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 357808012183 Walker A/P-loop; other site 357808012184 ATP binding site [chemical binding]; other site 357808012185 Q-loop/lid; other site 357808012186 ABC transporter signature motif; other site 357808012187 Walker B; other site 357808012188 D-loop; other site 357808012189 H-loop/switch region; other site 357808012190 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 357808012191 putative carbohydrate binding site [chemical binding]; other site 357808012192 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808012193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808012194 S-adenosylmethionine binding site [chemical binding]; other site 357808012195 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808012196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808012197 S-adenosylmethionine binding site [chemical binding]; other site 357808012198 HEPN domain; Region: HEPN; pfam05168 357808012199 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808012200 active site 357808012201 NTP binding site [chemical binding]; other site 357808012202 metal binding triad [ion binding]; metal-binding site 357808012203 antibiotic binding site [chemical binding]; other site 357808012204 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808012205 active site 357808012206 NTP binding site [chemical binding]; other site 357808012207 metal binding triad [ion binding]; metal-binding site 357808012208 antibiotic binding site [chemical binding]; other site 357808012209 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808012210 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808012211 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 357808012212 DDE superfamily endonuclease; Region: DDE_4; pfam13359 357808012213 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 357808012214 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 357808012215 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 357808012216 Protein of unknown function DUF86; Region: DUF86; pfam01934 357808012217 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808012218 NTP binding site [chemical binding]; other site 357808012219 metal binding triad [ion binding]; metal-binding site 357808012220 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357808012221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808012222 NAD(P) binding site [chemical binding]; other site 357808012223 active site 357808012224 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 357808012225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808012226 active site 357808012227 phosphorylation site [posttranslational modification] 357808012228 intermolecular recognition site; other site 357808012229 dimerization interface [polypeptide binding]; other site 357808012230 ANTAR domain; Region: ANTAR; pfam03861 357808012231 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 357808012232 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 357808012233 CoA binding domain; Region: CoA_binding; smart00881 357808012234 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 357808012235 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 357808012236 putative ligand binding site [chemical binding]; other site 357808012237 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 357808012238 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 357808012239 Walker A/P-loop; other site 357808012240 ATP binding site [chemical binding]; other site 357808012241 Q-loop/lid; other site 357808012242 ABC transporter signature motif; other site 357808012243 Walker B; other site 357808012244 D-loop; other site 357808012245 H-loop/switch region; other site 357808012246 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 357808012247 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 357808012248 Walker A/P-loop; other site 357808012249 ATP binding site [chemical binding]; other site 357808012250 Q-loop/lid; other site 357808012251 ABC transporter signature motif; other site 357808012252 Walker B; other site 357808012253 D-loop; other site 357808012254 H-loop/switch region; other site 357808012255 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 357808012256 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357808012257 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 357808012258 TM-ABC transporter signature motif; other site 357808012259 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 357808012260 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 357808012261 TM-ABC transporter signature motif; other site 357808012262 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 357808012263 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 357808012264 cofactor binding site; other site 357808012265 DNA binding site [nucleotide binding] 357808012266 substrate interaction site [chemical binding]; other site 357808012267 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 357808012268 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 357808012269 additional DNA contacts [nucleotide binding]; other site 357808012270 mismatch recognition site; other site 357808012271 active site 357808012272 zinc binding site [ion binding]; other site 357808012273 DNA intercalation site [nucleotide binding]; other site 357808012274 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 357808012275 active site 357808012276 NAD binding site [chemical binding]; other site 357808012277 metal binding site [ion binding]; metal-binding site 357808012278 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 357808012279 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 357808012280 NAD binding site [chemical binding]; other site 357808012281 sugar binding site [chemical binding]; other site 357808012282 divalent metal binding site [ion binding]; other site 357808012283 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357808012284 dimer interface [polypeptide binding]; other site 357808012285 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 357808012286 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 357808012287 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357808012288 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 357808012289 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357808012290 active site 357808012291 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 357808012292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 357808012293 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357808012294 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357808012295 Zn2+ binding site [ion binding]; other site 357808012296 Mg2+ binding site [ion binding]; other site 357808012297 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 357808012298 synthetase active site [active] 357808012299 NTP binding site [chemical binding]; other site 357808012300 metal binding site [ion binding]; metal-binding site 357808012301 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 357808012302 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 357808012303 Domain of unknown function (DUF305); Region: DUF305; pfam03713 357808012304 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 357808012305 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 357808012306 active site 357808012307 substrate binding site [chemical binding]; other site 357808012308 metal binding site [ion binding]; metal-binding site 357808012309 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 357808012310 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 357808012311 active site 357808012312 catalytic site [active] 357808012313 Bacterial SH3 domain; Region: SH3_3; pfam08239 357808012314 Bacterial SH3 domain homologues; Region: SH3b; smart00287 357808012315 Bacterial SH3 domain; Region: SH3_3; pfam08239 357808012316 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 357808012317 NlpC/P60 family; Region: NLPC_P60; pfam00877 357808012318 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 357808012319 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 357808012320 substrate binding site; other site 357808012321 metal-binding site 357808012322 Oligomer interface; other site 357808012323 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 357808012324 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 357808012325 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 357808012326 putative active site [active] 357808012327 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 357808012328 oligomerisation interface [polypeptide binding]; other site 357808012329 mobile loop; other site 357808012330 roof hairpin; other site 357808012331 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 357808012332 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 357808012333 ring oligomerisation interface [polypeptide binding]; other site 357808012334 ATP/Mg binding site [chemical binding]; other site 357808012335 stacking interactions; other site 357808012336 hinge regions; other site 357808012337 monogalactosyldiacylglycerol synthase; Region: PLN02605 357808012338 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 357808012339 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808012340 hypothetical protein; Provisional; Region: PRK08912 357808012341 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357808012342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808012343 homodimer interface [polypeptide binding]; other site 357808012344 catalytic residue [active] 357808012345 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 357808012346 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 357808012347 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808012348 putative active site [active] 357808012349 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 357808012350 agmatinase; Region: agmatinase; TIGR01230 357808012351 Arginase family; Region: Arginase; cd09989 357808012352 active site 357808012353 Mn binding site [ion binding]; other site 357808012354 oligomer interface [polypeptide binding]; other site 357808012355 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 357808012356 heme-binding residues [chemical binding]; other site 357808012357 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357808012358 molybdopterin cofactor binding site; other site 357808012359 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 357808012360 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 357808012361 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 357808012362 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 357808012363 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 357808012364 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 357808012365 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357808012366 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 357808012367 FAD binding site [chemical binding]; other site 357808012368 homotetramer interface [polypeptide binding]; other site 357808012369 substrate binding pocket [chemical binding]; other site 357808012370 catalytic base [active] 357808012371 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 357808012372 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 357808012373 Walker A/P-loop; other site 357808012374 ATP binding site [chemical binding]; other site 357808012375 Q-loop/lid; other site 357808012376 ABC transporter signature motif; other site 357808012377 Walker B; other site 357808012378 D-loop; other site 357808012379 H-loop/switch region; other site 357808012380 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 357808012381 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 357808012382 Walker A/P-loop; other site 357808012383 ATP binding site [chemical binding]; other site 357808012384 Q-loop/lid; other site 357808012385 ABC transporter signature motif; other site 357808012386 Walker B; other site 357808012387 D-loop; other site 357808012388 H-loop/switch region; other site 357808012389 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 357808012390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808012391 dimer interface [polypeptide binding]; other site 357808012392 conserved gate region; other site 357808012393 putative PBP binding loops; other site 357808012394 ABC-ATPase subunit interface; other site 357808012395 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 357808012396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808012397 dimer interface [polypeptide binding]; other site 357808012398 conserved gate region; other site 357808012399 putative PBP binding loops; other site 357808012400 ABC-ATPase subunit interface; other site 357808012401 PBP superfamily domain; Region: PBP_like_2; cl17296 357808012402 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 357808012403 PhoU domain; Region: PhoU; pfam01895 357808012404 PhoU domain; Region: PhoU; pfam01895 357808012405 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 357808012406 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 357808012407 Walker A/P-loop; other site 357808012408 ATP binding site [chemical binding]; other site 357808012409 Q-loop/lid; other site 357808012410 ABC transporter signature motif; other site 357808012411 Walker B; other site 357808012412 D-loop; other site 357808012413 H-loop/switch region; other site 357808012414 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 357808012415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808012416 dimer interface [polypeptide binding]; other site 357808012417 conserved gate region; other site 357808012418 putative PBP binding loops; other site 357808012419 ABC-ATPase subunit interface; other site 357808012420 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 357808012421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808012422 dimer interface [polypeptide binding]; other site 357808012423 conserved gate region; other site 357808012424 putative PBP binding loops; other site 357808012425 ABC-ATPase subunit interface; other site 357808012426 PBP superfamily domain; Region: PBP_like_2; cl17296 357808012427 PBP superfamily domain; Region: PBP_like_2; cl17296 357808012428 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808012429 dimerization interface [polypeptide binding]; other site 357808012430 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808012431 PAS domain; Region: PAS; smart00091 357808012432 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 357808012433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808012434 dimer interface [polypeptide binding]; other site 357808012435 phosphorylation site [posttranslational modification] 357808012436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808012437 ATP binding site [chemical binding]; other site 357808012438 G-X-G motif; other site 357808012439 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808012440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808012441 active site 357808012442 phosphorylation site [posttranslational modification] 357808012443 intermolecular recognition site; other site 357808012444 dimerization interface [polypeptide binding]; other site 357808012445 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808012446 DNA binding site [nucleotide binding] 357808012447 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 357808012448 active site 357808012449 catalytic residues [active] 357808012450 metal binding site [ion binding]; metal-binding site 357808012451 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 357808012452 putative ligand binding site [chemical binding]; other site 357808012453 isocitrate lyase; Provisional; Region: PRK15063 357808012454 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 357808012455 tetramer interface [polypeptide binding]; other site 357808012456 active site 357808012457 Mg2+/Mn2+ binding site [ion binding]; other site 357808012458 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 357808012459 malate synthase A; Region: malate_syn_A; TIGR01344 357808012460 active site 357808012461 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 357808012462 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 357808012463 inhibitor-cofactor binding pocket; inhibition site 357808012464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808012465 catalytic residue [active] 357808012466 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 357808012467 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 357808012468 NAD(P) binding site [chemical binding]; other site 357808012469 homodimer interface [polypeptide binding]; other site 357808012470 substrate binding site [chemical binding]; other site 357808012471 active site 357808012472 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808012473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808012474 binding surface 357808012475 TPR motif; other site 357808012476 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808012477 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357808012478 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 357808012479 active site 357808012480 catalytic site [active] 357808012481 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 357808012482 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 357808012483 putative active site [active] 357808012484 putative catalytic site [active] 357808012485 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 357808012486 putative active site [active] 357808012487 putative catalytic site [active] 357808012488 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 357808012489 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 357808012490 CoA-transferase family III; Region: CoA_transf_3; pfam02515 357808012491 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 357808012492 CoA-transferase family III; Region: CoA_transf_3; pfam02515 357808012493 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 357808012494 CoA-transferase family III; Region: CoA_transf_3; pfam02515 357808012495 Uncharacterized conserved protein [Function unknown]; Region: COG3777 357808012496 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 357808012497 active site 2 [active] 357808012498 active site 1 [active] 357808012499 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 357808012500 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 357808012501 Cysteine-rich domain; Region: CCG; pfam02754 357808012502 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 357808012503 putative homodimer interface [polypeptide binding]; other site 357808012504 putative active site pocket [active] 357808012505 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 357808012506 phage shock protein A; Region: phageshock_pspA; TIGR02977 357808012507 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 357808012508 DNA methylase; Region: N6_N4_Mtase; pfam01555 357808012509 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 357808012510 Type II restriction enzyme SfiI; Region: RestrictionSfiI; pfam11487 357808012511 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 357808012512 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 357808012513 Sulfate transporter family; Region: Sulfate_transp; pfam00916 357808012514 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 357808012515 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 357808012516 active site residue [active] 357808012517 fructose 1,6-bisphosphatase II; Reviewed; Region: glpX; PRK09479 357808012518 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 357808012519 active site 357808012520 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 357808012521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808012522 PAS fold; Region: PAS_3; pfam08447 357808012523 putative active site [active] 357808012524 heme pocket [chemical binding]; other site 357808012525 PAS domain S-box; Region: sensory_box; TIGR00229 357808012526 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808012527 putative active site [active] 357808012528 heme pocket [chemical binding]; other site 357808012529 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808012530 Homeobox associated leucine zipper; Region: HALZ; pfam02183 357808012531 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 357808012532 Uncharacterized conserved protein [Function unknown]; Region: COG2912 357808012533 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 357808012534 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 357808012535 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357808012536 NAD(P) binding site [chemical binding]; other site 357808012537 catalytic residues [active] 357808012538 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 357808012539 putative ADP-ribose binding site [chemical binding]; other site 357808012540 putative active site [active] 357808012541 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 357808012542 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 357808012543 PAS domain S-box; Region: sensory_box; TIGR00229 357808012544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808012545 putative active site [active] 357808012546 heme pocket [chemical binding]; other site 357808012547 PAS domain S-box; Region: sensory_box; TIGR00229 357808012548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357808012549 putative active site [active] 357808012550 heme pocket [chemical binding]; other site 357808012551 PAS domain; Region: PAS; smart00091 357808012552 PAS fold; Region: PAS_4; pfam08448 357808012553 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808012554 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 357808012555 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 357808012556 trimer interface [polypeptide binding]; other site 357808012557 active site 357808012558 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 357808012559 active site 357808012560 Ap6A binding site [chemical binding]; other site 357808012561 nudix motif; other site 357808012562 metal binding site [ion binding]; metal-binding site 357808012563 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 357808012564 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 357808012565 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 357808012566 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357808012567 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808012568 putative active site [active] 357808012569 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 357808012570 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 357808012571 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 357808012572 catalytic triad [active] 357808012573 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 357808012574 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 357808012575 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 357808012576 hypothetical protein; Provisional; Region: PRK06753 357808012577 hypothetical protein; Provisional; Region: PRK07236 357808012578 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 357808012579 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 357808012580 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 357808012581 GDP-binding site [chemical binding]; other site 357808012582 ACT binding site; other site 357808012583 IMP binding site; other site 357808012584 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 357808012585 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357808012586 P-loop; other site 357808012587 Magnesium ion binding site [ion binding]; other site 357808012588 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 357808012589 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 357808012590 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 357808012591 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 357808012592 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 357808012593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357808012594 active site 357808012595 motif I; other site 357808012596 motif II; other site 357808012597 Chain length determinant protein; Region: Wzz; cl15801 357808012598 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 357808012599 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 357808012600 trimer interface [polypeptide binding]; other site 357808012601 active site 357808012602 substrate binding site [chemical binding]; other site 357808012603 CoA binding site [chemical binding]; other site 357808012604 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 357808012605 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 357808012606 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 357808012607 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 357808012608 Ligand binding site; other site 357808012609 Putative Catalytic site; other site 357808012610 DXD motif; other site 357808012611 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 357808012612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357808012613 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 357808012614 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 357808012615 B12 binding site [chemical binding]; other site 357808012616 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808012617 FeS/SAM binding site; other site 357808012618 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 357808012619 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808012620 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808012621 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 357808012622 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 357808012623 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808012624 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808012625 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 357808012626 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 357808012627 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357808012628 Probable Catalytic site; other site 357808012629 metal-binding site 357808012630 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 357808012631 HlyD family secretion protein; Region: HlyD_3; pfam13437 357808012632 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808012633 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 357808012634 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 357808012635 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 357808012636 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 357808012637 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357808012638 Probable Catalytic site; other site 357808012639 metal-binding site 357808012640 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 357808012641 BNR repeat-like domain; Region: BNR_2; pfam13088 357808012642 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 357808012643 PQQ-like domain; Region: PQQ_2; pfam13360 357808012644 Trp docking motif [polypeptide binding]; other site 357808012645 active site 357808012646 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 357808012647 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357808012648 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 357808012649 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 357808012650 Trp docking motif [polypeptide binding]; other site 357808012651 PQQ-like domain; Region: PQQ_2; pfam13360 357808012652 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 357808012653 active site 357808012654 Domain of unknown function DUF11; Region: DUF11; pfam01345 357808012655 Domain of unknown function DUF11; Region: DUF11; pfam01345 357808012656 Domain of unknown function DUF11; Region: DUF11; pfam01345 357808012657 Domain of unknown function DUF11; Region: DUF11; pfam01345 357808012658 Domain of unknown function DUF11; Region: DUF11; pfam01345 357808012659 Restriction endonuclease; Region: Mrr_cat; pfam04471 357808012660 Bacterial SH3 domain; Region: SH3_3; pfam08239 357808012661 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 357808012662 non-specific DNA interactions [nucleotide binding]; other site 357808012663 DNA binding site [nucleotide binding] 357808012664 sequence specific DNA binding site [nucleotide binding]; other site 357808012665 putative cAMP binding site [chemical binding]; other site 357808012666 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 357808012667 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 357808012668 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357808012669 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357808012670 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357808012671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808012672 dimer interface [polypeptide binding]; other site 357808012673 conserved gate region; other site 357808012674 putative PBP binding loops; other site 357808012675 ABC-ATPase subunit interface; other site 357808012676 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357808012677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808012678 dimer interface [polypeptide binding]; other site 357808012679 conserved gate region; other site 357808012680 putative PBP binding loops; other site 357808012681 ABC-ATPase subunit interface; other site 357808012682 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 357808012683 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 357808012684 putative ligand binding site [chemical binding]; other site 357808012685 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 357808012686 classical (c) SDRs; Region: SDR_c; cd05233 357808012687 NAD(P) binding site [chemical binding]; other site 357808012688 active site 357808012689 dihydroorotase; Provisional; Region: PRK09237 357808012690 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357808012691 active site 357808012692 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357808012693 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 357808012694 Walker A/P-loop; other site 357808012695 ATP binding site [chemical binding]; other site 357808012696 Q-loop/lid; other site 357808012697 ABC transporter signature motif; other site 357808012698 Walker B; other site 357808012699 D-loop; other site 357808012700 H-loop/switch region; other site 357808012701 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 357808012702 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357808012703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357808012704 Histidine kinase; Region: HisKA_3; pfam07730 357808012705 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357808012706 Mg2+ binding site [ion binding]; other site 357808012707 G-X-G motif; other site 357808012708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808012709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808012710 active site 357808012711 phosphorylation site [posttranslational modification] 357808012712 intermolecular recognition site; other site 357808012713 dimerization interface [polypeptide binding]; other site 357808012714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808012715 DNA binding residues [nucleotide binding] 357808012716 dimerization interface [polypeptide binding]; other site 357808012717 enoyl-CoA hydratase; Validated; Region: PRK08139 357808012718 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357808012719 substrate binding site [chemical binding]; other site 357808012720 oxyanion hole (OAH) forming residues; other site 357808012721 trimer interface [polypeptide binding]; other site 357808012722 Uncharacterized conserved protein [Function unknown]; Region: COG1434 357808012723 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 357808012724 putative active site [active] 357808012725 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 357808012726 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 357808012727 putative trimer interface [polypeptide binding]; other site 357808012728 putative CoA binding site [chemical binding]; other site 357808012729 Bacterial sugar transferase; Region: Bac_transf; pfam02397 357808012730 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 357808012731 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808012732 putative ADP-binding pocket [chemical binding]; other site 357808012733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808012734 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808012735 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357808012736 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357808012737 Probable Catalytic site; other site 357808012738 metal-binding site 357808012739 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 357808012740 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808012741 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808012742 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808012743 O-Antigen ligase; Region: Wzy_C; pfam04932 357808012744 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 357808012745 Chain length determinant protein; Region: Wzz; pfam02706 357808012746 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 357808012747 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357808012748 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808012749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808012750 active site 357808012751 phosphorylation site [posttranslational modification] 357808012752 intermolecular recognition site; other site 357808012753 dimerization interface [polypeptide binding]; other site 357808012754 Right handed beta helix region; Region: Beta_helix; pfam13229 357808012755 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808012756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808012757 active site 357808012758 phosphorylation site [posttranslational modification] 357808012759 intermolecular recognition site; other site 357808012760 dimerization interface [polypeptide binding]; other site 357808012761 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808012762 DNA binding residues [nucleotide binding] 357808012763 dimerization interface [polypeptide binding]; other site 357808012764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357808012765 Histidine kinase; Region: HisKA_3; pfam07730 357808012766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808012767 ATP binding site [chemical binding]; other site 357808012768 Mg2+ binding site [ion binding]; other site 357808012769 G-X-G motif; other site 357808012770 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 357808012771 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808012772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808012773 S-adenosylmethionine binding site [chemical binding]; other site 357808012774 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357808012775 Beta-lactamase; Region: Beta-lactamase; pfam00144 357808012776 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808012777 putative active site [active] 357808012778 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 357808012779 active site 357808012780 catalytic site [active] 357808012781 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 357808012782 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 357808012783 DNA methylase; Region: N6_N4_Mtase; cl17433 357808012784 DNA methylase; Region: N6_N4_Mtase; pfam01555 357808012785 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 357808012786 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 357808012787 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 357808012788 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 357808012789 RNA binding site [nucleotide binding]; other site 357808012790 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 357808012791 RNA binding site [nucleotide binding]; other site 357808012792 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 357808012793 RNA binding site [nucleotide binding]; other site 357808012794 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 357808012795 RNA binding site [nucleotide binding]; other site 357808012796 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 357808012797 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 357808012798 ATP-NAD kinase; Region: NAD_kinase; pfam01513 357808012799 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 357808012800 TrkA-N domain; Region: TrkA_N; pfam02254 357808012801 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 357808012802 TrkA-N domain; Region: TrkA_N; pfam02254 357808012803 TrkA-C domain; Region: TrkA_C; pfam02080 357808012804 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 357808012805 Cna protein B-type domain; Region: Cna_B; pfam05738 357808012806 Cna protein B-type domain; Region: Cna_B; pfam05738 357808012807 CARDB; Region: CARDB; pfam07705 357808012808 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 357808012809 Clp amino terminal domain; Region: Clp_N; pfam02861 357808012810 Clp amino terminal domain; Region: Clp_N; pfam02861 357808012811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808012812 Walker A motif; other site 357808012813 ATP binding site [chemical binding]; other site 357808012814 Walker B motif; other site 357808012815 arginine finger; other site 357808012816 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 357808012817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808012818 Walker A motif; other site 357808012819 ATP binding site [chemical binding]; other site 357808012820 Walker B motif; other site 357808012821 arginine finger; other site 357808012822 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 357808012823 RibD C-terminal domain; Region: RibD_C; cl17279 357808012824 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 357808012825 heat shock protein 90; Provisional; Region: PRK05218 357808012826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808012827 ATP binding site [chemical binding]; other site 357808012828 Mg2+ binding site [ion binding]; other site 357808012829 G-X-G motif; other site 357808012830 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357808012831 HlyD family secretion protein; Region: HlyD_3; pfam13437 357808012832 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 357808012833 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 357808012834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357808012835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357808012836 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357808012837 Homeodomain-like domain; Region: HTH_23; pfam13384 357808012838 Winged helix-turn helix; Region: HTH_29; pfam13551 357808012839 Homeodomain-like domain; Region: HTH_32; pfam13565 357808012840 Double zinc ribbon; Region: DZR; pfam12773 357808012841 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 357808012842 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 357808012843 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357808012844 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 357808012845 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 357808012846 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357808012847 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357808012848 active site 357808012849 Radical SAM superfamily; Region: Radical_SAM; pfam04055 357808012850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357808012851 FeS/SAM binding site; other site 357808012852 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 357808012853 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 357808012854 Moco binding site; other site 357808012855 metal coordination site [ion binding]; other site 357808012856 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 357808012857 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 357808012858 CoA-binding site [chemical binding]; other site 357808012859 ATP-binding [chemical binding]; other site 357808012860 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 357808012861 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 357808012862 active site 357808012863 putative substrate binding pocket [chemical binding]; other site 357808012864 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 357808012865 putative metal binding residues [ion binding]; other site 357808012866 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 357808012867 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 357808012868 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 357808012869 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808012870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808012871 active site 357808012872 phosphorylation site [posttranslational modification] 357808012873 intermolecular recognition site; other site 357808012874 dimerization interface [polypeptide binding]; other site 357808012875 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808012876 DNA binding residues [nucleotide binding] 357808012877 dimerization interface [polypeptide binding]; other site 357808012878 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 357808012879 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 357808012880 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 357808012881 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 357808012882 Uncharacterized conserved protein [Function unknown]; Region: COG2353 357808012883 Bacterial transcriptional activator domain; Region: BTAD; smart01043 357808012884 Predicted ATPase [General function prediction only]; Region: COG3899 357808012885 AAA ATPase domain; Region: AAA_16; pfam13191 357808012886 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 357808012887 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 357808012888 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 357808012889 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 357808012890 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 357808012891 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 357808012892 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 357808012893 WYL domain; Region: WYL; pfam13280 357808012894 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 357808012895 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 357808012896 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 357808012897 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808012898 putative active site [active] 357808012899 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357808012900 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357808012901 active site 357808012902 metal binding site [ion binding]; metal-binding site 357808012903 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 357808012904 Amino acid permease; Region: AA_permease; pfam00324 357808012905 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 357808012906 conserved cys residue [active] 357808012907 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 357808012908 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 357808012909 acyl-activating enzyme (AAE) consensus motif; other site 357808012910 putative AMP binding site [chemical binding]; other site 357808012911 putative active site [active] 357808012912 putative CoA binding site [chemical binding]; other site 357808012913 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 357808012914 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 357808012915 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 357808012916 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 357808012917 Bacterial transcriptional activator domain; Region: BTAD; smart01043 357808012918 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 357808012919 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 357808012920 NAD(P) binding site [chemical binding]; other site 357808012921 homotetramer interface [polypeptide binding]; other site 357808012922 homodimer interface [polypeptide binding]; other site 357808012923 active site 357808012924 beta-ketothiolase; Provisional; Region: PRK09051 357808012925 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 357808012926 dimer interface [polypeptide binding]; other site 357808012927 active site 357808012928 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 357808012929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808012930 Coenzyme A binding pocket [chemical binding]; other site 357808012931 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 357808012932 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 357808012933 Uncharacterized ACR (DUF711); Region: DUF711; pfam05167 357808012934 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 357808012935 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 357808012936 putative ligand binding site [chemical binding]; other site 357808012937 putative NAD binding site [chemical binding]; other site 357808012938 catalytic site [active] 357808012939 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 357808012940 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 357808012941 active site 357808012942 dimer interface [polypeptide binding]; other site 357808012943 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 357808012944 dimer interface [polypeptide binding]; other site 357808012945 active site 357808012946 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 357808012947 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 357808012948 Glycoprotease family; Region: Peptidase_M22; pfam00814 357808012949 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 357808012950 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 357808012951 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 357808012952 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 357808012953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357808012954 Walker A motif; other site 357808012955 ATP binding site [chemical binding]; other site 357808012956 Walker B motif; other site 357808012957 arginine finger; other site 357808012958 Peptidase family M41; Region: Peptidase_M41; pfam01434 357808012959 hypothetical protein; Validated; Region: PRK00110 357808012960 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 357808012961 active site 357808012962 putative DNA-binding cleft [nucleotide binding]; other site 357808012963 dimer interface [polypeptide binding]; other site 357808012964 SseB protein; Region: SseB; cl06279 357808012965 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 357808012966 dimer interface [polypeptide binding]; other site 357808012967 ligand binding site [chemical binding]; other site 357808012968 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 357808012969 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 357808012970 Zn binding site [ion binding]; other site 357808012971 toxin interface [polypeptide binding]; other site 357808012972 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 357808012973 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 357808012974 Protein of unknown function (DUF433); Region: DUF433; pfam04255 357808012975 H+ Antiporter protein; Region: 2A0121; TIGR00900 357808012976 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 357808012977 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357808012978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808012979 S-adenosylmethionine binding site [chemical binding]; other site 357808012980 Domain of unknown function DUF77; Region: DUF77; cl00307 357808012981 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808012982 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 357808012983 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 357808012984 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808012985 Coenzyme A binding pocket [chemical binding]; other site 357808012986 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 357808012987 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 357808012988 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 357808012989 NAD(P) binding site [chemical binding]; other site 357808012990 Response regulator receiver domain; Region: Response_reg; pfam00072 357808012991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808012992 active site 357808012993 phosphorylation site [posttranslational modification] 357808012994 intermolecular recognition site; other site 357808012995 dimerization interface [polypeptide binding]; other site 357808012996 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 357808012997 Putative zinc-finger; Region: zf-HC2; pfam13490 357808012998 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 357808012999 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808013000 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808013001 DNA binding residues [nucleotide binding] 357808013002 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808013003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357808013004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808013005 ATP binding site [chemical binding]; other site 357808013006 Mg2+ binding site [ion binding]; other site 357808013007 G-X-G motif; other site 357808013008 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 357808013009 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 357808013010 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 357808013011 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 357808013012 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 357808013013 homodimer interface [polypeptide binding]; other site 357808013014 NADP binding site [chemical binding]; other site 357808013015 substrate binding site [chemical binding]; other site 357808013016 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 357808013017 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 357808013018 Substrate binding site; other site 357808013019 Mg++ binding site; other site 357808013020 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 357808013021 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 357808013022 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 357808013023 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357808013024 active site 357808013025 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 357808013026 Domain of unknown function DUF21; Region: DUF21; pfam01595 357808013027 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 357808013028 Transporter associated domain; Region: CorC_HlyC; smart01091 357808013029 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 357808013030 active site 357808013031 catalytic motif [active] 357808013032 Zn binding site [ion binding]; other site 357808013033 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 357808013034 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 357808013035 active site 357808013036 Substrate binding site; other site 357808013037 Mg++ binding site; other site 357808013038 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 357808013039 putative trimer interface [polypeptide binding]; other site 357808013040 putative CoA binding site [chemical binding]; other site 357808013041 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 357808013042 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 357808013043 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 357808013044 EamA-like transporter family; Region: EamA; pfam00892 357808013045 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 357808013046 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808013047 GAF domain; Region: GAF_3; pfam13492 357808013048 GAF domain; Region: GAF_2; pfam13185 357808013049 GAF domain; Region: GAF_3; pfam13492 357808013050 GAF domain; Region: GAF_3; pfam13492 357808013051 GAF domain; Region: GAF_2; pfam13185 357808013052 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357808013053 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357808013054 metal binding site [ion binding]; metal-binding site 357808013055 active site 357808013056 I-site; other site 357808013057 multidrug resistance protein MdtH; Provisional; Region: PRK11646 357808013058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808013059 putative substrate translocation pore; other site 357808013060 Bacterial SH3 domain; Region: SH3_3; pfam08239 357808013061 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 357808013062 hypothetical protein; Provisional; Region: PRK06815 357808013063 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 357808013064 tetramer interface [polypeptide binding]; other site 357808013065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808013066 catalytic residue [active] 357808013067 DNA polymerase III subunit beta; Validated; Region: PRK05643 357808013068 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 357808013069 putative DNA binding surface [nucleotide binding]; other site 357808013070 dimer interface [polypeptide binding]; other site 357808013071 beta-clamp/clamp loader binding surface; other site 357808013072 beta-clamp/translesion DNA polymerase binding surface; other site 357808013073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808013074 TPR repeat; Region: TPR_11; pfam13414 357808013075 binding surface 357808013076 TPR motif; other site 357808013077 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 357808013078 Predicted membrane protein [Function unknown]; Region: COG3463 357808013079 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 357808013080 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357808013081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808013082 S-adenosylmethionine binding site [chemical binding]; other site 357808013083 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 357808013084 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808013085 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808013086 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 357808013087 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 357808013088 Ligand binding site; other site 357808013089 Putative Catalytic site; other site 357808013090 DXD motif; other site 357808013091 Protein of unknown function DUF86; Region: DUF86; pfam01934 357808013092 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808013093 active site 357808013094 NTP binding site [chemical binding]; other site 357808013095 metal binding triad [ion binding]; metal-binding site 357808013096 antibiotic binding site [chemical binding]; other site 357808013097 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 357808013098 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 357808013099 active site 357808013100 dimer interface [polypeptide binding]; other site 357808013101 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 357808013102 Ligand Binding Site [chemical binding]; other site 357808013103 Molecular Tunnel; other site 357808013104 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808013105 active site 357808013106 NTP binding site [chemical binding]; other site 357808013107 metal binding triad [ion binding]; metal-binding site 357808013108 antibiotic binding site [chemical binding]; other site 357808013109 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 357808013110 putative active site [active] 357808013111 putative catalytic site [active] 357808013112 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357808013113 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357808013114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808013115 S-adenosylmethionine binding site [chemical binding]; other site 357808013116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808013117 S-adenosylmethionine binding site [chemical binding]; other site 357808013118 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 357808013119 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808013120 putative active site [active] 357808013121 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 357808013122 four helix bundle protein; Region: TIGR02436 357808013123 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 357808013124 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 357808013125 inhibitor-cofactor binding pocket; inhibition site 357808013126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808013127 catalytic residue [active] 357808013128 putative trimer interface [polypeptide binding]; other site 357808013129 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 357808013130 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 357808013131 putative CoA binding site [chemical binding]; other site 357808013132 putative trimer interface [polypeptide binding]; other site 357808013133 putative active site [active] 357808013134 putative substrate binding site [chemical binding]; other site 357808013135 putative CoA binding site [chemical binding]; other site 357808013136 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 357808013137 active site 357808013138 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 357808013139 homodimer interface [polypeptide binding]; other site 357808013140 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357808013141 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357808013142 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357808013143 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808013144 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808013145 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808013146 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 357808013147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808013148 S-adenosylmethionine binding site [chemical binding]; other site 357808013149 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357808013150 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808013151 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 357808013152 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357808013153 Probable Catalytic site; other site 357808013154 metal-binding site 357808013155 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 357808013156 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 357808013157 putative ADP-binding pocket [chemical binding]; other site 357808013158 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 357808013159 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 357808013160 active site 357808013161 dimer interface [polypeptide binding]; other site 357808013162 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 357808013163 Ligand Binding Site [chemical binding]; other site 357808013164 Molecular Tunnel; other site 357808013165 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808013166 putative active site [active] 357808013167 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808013168 putative active site [active] 357808013169 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808013170 putative active site [active] 357808013171 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808013172 putative active site [active] 357808013173 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808013174 putative active site [active] 357808013175 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808013176 putative active site [active] 357808013177 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808013178 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 357808013179 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 357808013180 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 357808013181 Ligand binding site; other site 357808013182 Putative Catalytic site; other site 357808013183 DXD motif; other site 357808013184 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808013185 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808013186 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 357808013187 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 357808013188 Response regulator receiver domain; Region: Response_reg; pfam00072 357808013189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808013190 active site 357808013191 phosphorylation site [posttranslational modification] 357808013192 intermolecular recognition site; other site 357808013193 dimerization interface [polypeptide binding]; other site 357808013194 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357808013195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357808013196 metal binding site [ion binding]; metal-binding site 357808013197 active site 357808013198 I-site; other site 357808013199 GAF domain; Region: GAF_3; pfam13492 357808013200 GAF domain; Region: GAF_2; pfam13185 357808013201 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808013202 GAF domain; Region: GAF; pfam01590 357808013203 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808013204 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808013205 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808013206 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808013207 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808013208 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808013209 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808013210 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808013211 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808013212 GAF domain; Region: GAF; pfam01590 357808013213 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808013214 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808013215 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808013216 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808013217 PAS domain; Region: PAS; smart00091 357808013218 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357808013219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808013220 dimer interface [polypeptide binding]; other site 357808013221 phosphorylation site [posttranslational modification] 357808013222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808013223 ATP binding site [chemical binding]; other site 357808013224 Mg2+ binding site [ion binding]; other site 357808013225 G-X-G motif; other site 357808013226 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357808013227 PGAP1-like protein; Region: PGAP1; pfam07819 357808013228 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 357808013229 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 357808013230 putative NAD(P) binding site [chemical binding]; other site 357808013231 catalytic Zn binding site [ion binding]; other site 357808013232 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808013233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808013234 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808013235 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 357808013236 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 357808013237 4Fe-4S binding domain; Region: Fer4; cl02805 357808013238 Cysteine-rich domain; Region: CCG; pfam02754 357808013239 Cysteine-rich domain; Region: CCG; pfam02754 357808013240 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 357808013241 Cysteine-rich domain; Region: CCG; pfam02754 357808013242 Cysteine-rich domain; Region: CCG; pfam02754 357808013243 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 357808013244 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 357808013245 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 357808013246 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 357808013247 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 357808013248 active site 357808013249 catalytic site [active] 357808013250 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 357808013251 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808013252 putative active site [active] 357808013253 YwiC-like protein; Region: YwiC; pfam14256 357808013254 Cupin domain; Region: Cupin_2; cl17218 357808013255 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357808013256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808013257 S-adenosylmethionine binding site [chemical binding]; other site 357808013258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357808013259 Iron permease FTR1 family; Region: FTR1; cl00475 357808013260 Imelysin; Region: Peptidase_M75; cl09159 357808013261 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 357808013262 kynureninase; Region: kynureninase; TIGR01814 357808013263 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357808013264 catalytic residue [active] 357808013265 Cytochrome c; Region: Cytochrom_C; cl11414 357808013266 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 357808013267 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 357808013268 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357808013269 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357808013270 catalytic residue [active] 357808013271 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357808013272 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 357808013273 Cysteine-rich domain; Region: CCG; pfam02754 357808013274 Cysteine-rich domain; Region: CCG; pfam02754 357808013275 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 357808013276 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 357808013277 active site 357808013278 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 357808013279 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357808013280 Zn2+ binding site [ion binding]; other site 357808013281 Mg2+ binding site [ion binding]; other site 357808013282 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 357808013283 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 357808013284 putative active site [active] 357808013285 CbiX; Region: CbiX; pfam01903 357808013286 active site 357808013287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357808013288 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357808013289 putative substrate translocation pore; other site 357808013290 Domain of unknown function (DUF4078); Region: DUF4078; pfam13300 357808013291 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357808013292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357808013293 dimer interface [polypeptide binding]; other site 357808013294 phosphorylation site [posttranslational modification] 357808013295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808013296 ATP binding site [chemical binding]; other site 357808013297 Mg2+ binding site [ion binding]; other site 357808013298 G-X-G motif; other site 357808013299 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808013300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808013301 active site 357808013302 phosphorylation site [posttranslational modification] 357808013303 intermolecular recognition site; other site 357808013304 dimerization interface [polypeptide binding]; other site 357808013305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808013306 DNA binding site [nucleotide binding] 357808013307 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 357808013308 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 357808013309 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357808013310 catalytic residues [active] 357808013311 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 357808013312 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 357808013313 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357808013314 putative ligand binding site [chemical binding]; other site 357808013315 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357808013316 dimerization interface [polypeptide binding]; other site 357808013317 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 357808013318 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 357808013319 N-acetyl-D-glucosamine binding site [chemical binding]; other site 357808013320 catalytic residue [active] 357808013321 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 357808013322 Recombination-activation protein 1 (RAG1); Region: RAG1; pfam12940 357808013323 translocation protein TolB; Provisional; Region: tolB; PRK02889 357808013324 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808013325 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808013326 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 357808013327 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 357808013328 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808013329 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 357808013330 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 357808013331 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 357808013332 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357808013333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808013334 ATP binding site [chemical binding]; other site 357808013335 G-X-G motif; other site 357808013336 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357808013337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808013338 active site 357808013339 phosphorylation site [posttranslational modification] 357808013340 intermolecular recognition site; other site 357808013341 dimerization interface [polypeptide binding]; other site 357808013342 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357808013343 DNA binding residues [nucleotide binding] 357808013344 dimerization interface [polypeptide binding]; other site 357808013345 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 357808013346 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 357808013347 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808013348 active site 357808013349 NTP binding site [chemical binding]; other site 357808013350 metal binding triad [ion binding]; metal-binding site 357808013351 antibiotic binding site [chemical binding]; other site 357808013352 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 357808013353 hypothetical protein; Reviewed; Region: PRK09588 357808013354 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 357808013355 Nucleoside recognition; Region: Gate; pfam07670 357808013356 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 357808013357 Nucleoside recognition; Region: Gate; pfam07670 357808013358 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 357808013359 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 357808013360 G1 box; other site 357808013361 GTP/Mg2+ binding site [chemical binding]; other site 357808013362 Switch I region; other site 357808013363 G2 box; other site 357808013364 G3 box; other site 357808013365 Switch II region; other site 357808013366 G4 box; other site 357808013367 G5 box; other site 357808013368 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 357808013369 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 357808013370 FeoA domain; Region: FeoA; pfam04023 357808013371 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 357808013372 DNA methylase; Region: N6_N4_Mtase; pfam01555 357808013373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808013374 S-adenosylmethionine binding site [chemical binding]; other site 357808013375 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808013376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808013377 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808013378 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 357808013379 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 357808013380 nucleotide binding pocket [chemical binding]; other site 357808013381 K-X-D-G motif; other site 357808013382 catalytic site [active] 357808013383 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 357808013384 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 357808013385 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 357808013386 Dimer interface [polypeptide binding]; other site 357808013387 BRCT sequence motif; other site 357808013388 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357808013389 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 357808013390 catalytic site [active] 357808013391 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808013392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808013393 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808013394 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357808013395 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 357808013396 Ligand binding site; other site 357808013397 Putative Catalytic site; other site 357808013398 DXD motif; other site 357808013399 Transcriptional regulator [Transcription]; Region: LytR; COG1316 357808013400 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 357808013401 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 357808013402 Amidinotransferase; Region: Amidinotransf; pfam02274 357808013403 acetylornithine deacetylase; Validated; Region: PRK06915 357808013404 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 357808013405 metal binding site [ion binding]; metal-binding site 357808013406 dimer interface [polypeptide binding]; other site 357808013407 BioY family; Region: BioY; pfam02632 357808013408 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 357808013409 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 357808013410 Mg++ binding site [ion binding]; other site 357808013411 putative catalytic motif [active] 357808013412 substrate binding site [chemical binding]; other site 357808013413 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 357808013414 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 357808013415 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357808013416 Zn binding site [ion binding]; other site 357808013417 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 357808013418 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357808013419 Zn binding site [ion binding]; other site 357808013420 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 357808013421 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 357808013422 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 357808013423 TrkA-N domain; Region: TrkA_N; pfam02254 357808013424 TrkA-C domain; Region: TrkA_C; pfam02080 357808013425 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357808013426 active site 357808013427 NTP binding site [chemical binding]; other site 357808013428 metal binding triad [ion binding]; metal-binding site 357808013429 antibiotic binding site [chemical binding]; other site 357808013430 Uncharacterized conserved protein [Function unknown]; Region: COG2445 357808013431 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 357808013432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808013433 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808013434 DNA binding residues [nucleotide binding] 357808013435 enolase; Provisional; Region: eno; PRK00077 357808013436 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 357808013437 dimer interface [polypeptide binding]; other site 357808013438 metal binding site [ion binding]; metal-binding site 357808013439 substrate binding pocket [chemical binding]; other site 357808013440 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 357808013441 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 357808013442 DRTGG domain; Region: DRTGG; pfam07085 357808013443 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 357808013444 CoA binding domain; Region: CoA_binding_2; pfam13380 357808013445 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 357808013446 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 357808013447 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 357808013448 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 357808013449 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 357808013450 HIGH motif; other site 357808013451 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 357808013452 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357808013453 active site 357808013454 KMSKS motif; other site 357808013455 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 357808013456 tRNA binding surface [nucleotide binding]; other site 357808013457 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357808013458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808013459 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 357808013460 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 357808013461 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357808013462 active site 357808013463 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357808013464 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 357808013465 active site 357808013466 catalytic tetrad [active] 357808013467 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 357808013468 elongation factor G; Reviewed; Region: PRK12740 357808013469 G1 box; other site 357808013470 putative GEF interaction site [polypeptide binding]; other site 357808013471 GTP/Mg2+ binding site [chemical binding]; other site 357808013472 Switch I region; other site 357808013473 G2 box; other site 357808013474 G3 box; other site 357808013475 Switch II region; other site 357808013476 G4 box; other site 357808013477 G5 box; other site 357808013478 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 357808013479 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 357808013480 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 357808013481 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 357808013482 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357808013483 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357808013484 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 357808013485 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 357808013486 putative [4Fe-4S] binding site [ion binding]; other site 357808013487 putative molybdopterin cofactor binding site [chemical binding]; other site 357808013488 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 357808013489 molybdopterin cofactor binding site; other site 357808013490 shikimate kinase; Reviewed; Region: aroK; PRK00131 357808013491 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 357808013492 ADP binding site [chemical binding]; other site 357808013493 magnesium binding site [ion binding]; other site 357808013494 putative shikimate binding site; other site 357808013495 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 357808013496 active site 357808013497 dimer interface [polypeptide binding]; other site 357808013498 metal binding site [ion binding]; metal-binding site 357808013499 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808013500 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357808013501 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 357808013502 Protein phosphatase 2C; Region: PP2C; pfam00481 357808013503 active site 357808013504 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 357808013505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808013506 ATP binding site [chemical binding]; other site 357808013507 Mg2+ binding site [ion binding]; other site 357808013508 G-X-G motif; other site 357808013509 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 357808013510 ATP binding site [chemical binding]; other site 357808013511 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 357808013512 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 357808013513 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 357808013514 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 357808013515 FeoA domain; Region: FeoA; pfam04023 357808013516 Protein of unknown function (DUF952); Region: DUF952; pfam06108 357808013517 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 357808013518 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 357808013519 putative N- and C-terminal domain interface [polypeptide binding]; other site 357808013520 putative active site [active] 357808013521 putative MgATP binding site [chemical binding]; other site 357808013522 catalytic site [active] 357808013523 metal binding site [ion binding]; metal-binding site 357808013524 putative carbohydrate binding site [chemical binding]; other site 357808013525 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 357808013526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357808013527 NAD(P) binding site [chemical binding]; other site 357808013528 active site 357808013529 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 357808013530 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 357808013531 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 357808013532 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 357808013533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808013534 dimer interface [polypeptide binding]; other site 357808013535 conserved gate region; other site 357808013536 putative PBP binding loops; other site 357808013537 ABC-ATPase subunit interface; other site 357808013538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808013539 ABC-ATPase subunit interface; other site 357808013540 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 357808013541 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 357808013542 oligomer interface [polypeptide binding]; other site 357808013543 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 357808013544 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 357808013545 oligomer interface [polypeptide binding]; other site 357808013546 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 357808013547 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 357808013548 oligomer interface [polypeptide binding]; other site 357808013549 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 357808013550 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 357808013551 Walker A/P-loop; other site 357808013552 ATP binding site [chemical binding]; other site 357808013553 Q-loop/lid; other site 357808013554 ABC transporter signature motif; other site 357808013555 Walker B; other site 357808013556 D-loop; other site 357808013557 H-loop/switch region; other site 357808013558 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 357808013559 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 357808013560 active site 357808013561 Ap6A binding site [chemical binding]; other site 357808013562 nudix motif; other site 357808013563 metal binding site [ion binding]; metal-binding site 357808013564 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 357808013565 MgtC family; Region: MgtC; pfam02308 357808013566 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 357808013567 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357808013568 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357808013569 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357808013570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808013571 dimer interface [polypeptide binding]; other site 357808013572 conserved gate region; other site 357808013573 putative PBP binding loops; other site 357808013574 ABC-ATPase subunit interface; other site 357808013575 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357808013576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808013577 dimer interface [polypeptide binding]; other site 357808013578 conserved gate region; other site 357808013579 putative PBP binding loops; other site 357808013580 ABC-ATPase subunit interface; other site 357808013581 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 357808013582 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357808013583 inhibitor-cofactor binding pocket; inhibition site 357808013584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357808013585 catalytic residue [active] 357808013586 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 357808013587 putative active site [active] 357808013588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357808013589 Coenzyme A binding pocket [chemical binding]; other site 357808013590 histidyl-tRNA synthetase; Region: hisS; TIGR00442 357808013591 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 357808013592 dimer interface [polypeptide binding]; other site 357808013593 motif 1; other site 357808013594 active site 357808013595 motif 2; other site 357808013596 motif 3; other site 357808013597 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 357808013598 anticodon binding site; other site 357808013599 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 357808013600 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 357808013601 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357808013602 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 357808013603 ATP cone domain; Region: ATP-cone; pfam03477 357808013604 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 357808013605 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 357808013606 Uncharacterized conserved protein [Function unknown]; Region: COG1262 357808013607 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 357808013608 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357808013609 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357808013610 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 357808013611 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 357808013612 DinB superfamily; Region: DinB_2; pfam12867 357808013613 cobalamin synthase; Reviewed; Region: cobS; PRK00235 357808013614 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 357808013615 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357808013616 catalytic core [active] 357808013617 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 357808013618 ABC1 family; Region: ABC1; cl17513 357808013619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357808013620 S-adenosylmethionine binding site [chemical binding]; other site 357808013621 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357808013622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357808013623 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357808013624 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 357808013625 DNA protecting protein DprA; Region: dprA; TIGR00732 357808013626 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 357808013627 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 357808013628 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 357808013629 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357808013630 RNA binding surface [nucleotide binding]; other site 357808013631 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 357808013632 active site 357808013633 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 357808013634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808013635 dimer interface [polypeptide binding]; other site 357808013636 conserved gate region; other site 357808013637 putative PBP binding loops; other site 357808013638 ABC-ATPase subunit interface; other site 357808013639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808013640 dimer interface [polypeptide binding]; other site 357808013641 conserved gate region; other site 357808013642 putative PBP binding loops; other site 357808013643 ABC-ATPase subunit interface; other site 357808013644 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 357808013645 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 357808013646 Walker A/P-loop; other site 357808013647 ATP binding site [chemical binding]; other site 357808013648 Q-loop/lid; other site 357808013649 ABC transporter signature motif; other site 357808013650 Walker B; other site 357808013651 D-loop; other site 357808013652 H-loop/switch region; other site 357808013653 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 357808013654 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 357808013655 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 357808013656 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808013657 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808013658 active site 357808013659 ATP binding site [chemical binding]; other site 357808013660 substrate binding site [chemical binding]; other site 357808013661 activation loop (A-loop); other site 357808013662 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808013663 Double zinc ribbon; Region: DZR; pfam12773 357808013664 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 357808013665 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 357808013666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808013667 dimer interface [polypeptide binding]; other site 357808013668 conserved gate region; other site 357808013669 putative PBP binding loops; other site 357808013670 ABC-ATPase subunit interface; other site 357808013671 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 357808013672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357808013673 dimer interface [polypeptide binding]; other site 357808013674 conserved gate region; other site 357808013675 putative PBP binding loops; other site 357808013676 ABC-ATPase subunit interface; other site 357808013677 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 357808013678 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 357808013679 peptide binding site [polypeptide binding]; other site 357808013680 dimer interface [polypeptide binding]; other site 357808013681 HEAT repeats; Region: HEAT_2; pfam13646 357808013682 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 357808013683 protein binding surface [polypeptide binding]; other site 357808013684 HEAT repeats; Region: HEAT_2; pfam13646 357808013685 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 357808013686 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 357808013687 NADP binding site [chemical binding]; other site 357808013688 active site 357808013689 putative substrate binding site [chemical binding]; other site 357808013690 ribonuclease III; Reviewed; Region: rnc; PRK00102 357808013691 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 357808013692 dimerization interface [polypeptide binding]; other site 357808013693 active site 357808013694 metal binding site [ion binding]; metal-binding site 357808013695 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 357808013696 dsRNA binding site [nucleotide binding]; other site 357808013697 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 357808013698 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 357808013699 dimer interface [polypeptide binding]; other site 357808013700 active site 357808013701 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357808013702 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357808013703 active site 357808013704 ATP binding site [chemical binding]; other site 357808013705 substrate binding site [chemical binding]; other site 357808013706 activation loop (A-loop); other site 357808013707 TPR repeat; Region: TPR_11; pfam13414 357808013708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808013709 binding surface 357808013710 TPR motif; other site 357808013711 TPR repeat; Region: TPR_11; pfam13414 357808013712 TPR repeat; Region: TPR_11; pfam13414 357808013713 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357808013714 binding surface 357808013715 TPR motif; other site 357808013716 TPR repeat; Region: TPR_11; pfam13414 357808013717 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 357808013718 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357808013719 Probable Catalytic site; other site 357808013720 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357808013721 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 357808013722 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 357808013723 putative metal binding site; other site 357808013724 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 357808013725 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357808013726 Probable Catalytic site; other site 357808013727 metal-binding site 357808013728 Response regulator receiver domain; Region: Response_reg; pfam00072 357808013729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808013730 active site 357808013731 phosphorylation site [posttranslational modification] 357808013732 intermolecular recognition site; other site 357808013733 dimerization interface [polypeptide binding]; other site 357808013734 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 357808013735 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357808013736 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 357808013737 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 357808013738 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357808013739 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 357808013740 acyl-activating enzyme (AAE) consensus motif; other site 357808013741 acyl-activating enzyme (AAE) consensus motif; other site 357808013742 putative AMP binding site [chemical binding]; other site 357808013743 putative active site [active] 357808013744 putative CoA binding site [chemical binding]; other site 357808013745 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 357808013746 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357808013747 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 357808013748 acyl-activating enzyme (AAE) consensus motif; other site 357808013749 putative AMP binding site [chemical binding]; other site 357808013750 putative active site [active] 357808013751 putative CoA binding site [chemical binding]; other site 357808013752 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 357808013753 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 357808013754 TPP-binding site [chemical binding]; other site 357808013755 dimer interface [polypeptide binding]; other site 357808013756 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 357808013757 PYR/PP interface [polypeptide binding]; other site 357808013758 dimer interface [polypeptide binding]; other site 357808013759 TPP binding site [chemical binding]; other site 357808013760 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 357808013761 active site 357808013762 intersubunit interactions; other site 357808013763 catalytic residue [active] 357808013764 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 357808013765 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 357808013766 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357808013767 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357808013768 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357808013769 DNA binding residues [nucleotide binding] 357808013770 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357808013771 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357808013772 Walker A/P-loop; other site 357808013773 ATP binding site [chemical binding]; other site 357808013774 Q-loop/lid; other site 357808013775 ABC transporter signature motif; other site 357808013776 Walker B; other site 357808013777 D-loop; other site 357808013778 H-loop/switch region; other site 357808013779 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 357808013780 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 357808013781 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357808013782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808013783 active site 357808013784 phosphorylation site [posttranslational modification] 357808013785 intermolecular recognition site; other site 357808013786 dimerization interface [polypeptide binding]; other site 357808013787 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357808013788 DNA binding site [nucleotide binding] 357808013789 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357808013790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357808013791 active site 357808013792 phosphorylation site [posttranslational modification] 357808013793 intermolecular recognition site; other site 357808013794 dimerization interface [polypeptide binding]; other site 357808013795 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 357808013796 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357808013797 FG-GAP repeat; Region: FG-GAP_2; pfam14312 357808013798 FG-GAP repeat; Region: FG-GAP_2; pfam14312 357808013799 FG-GAP repeat; Region: FG-GAP_2; pfam14312 357808013800 FG-GAP repeat; Region: FG-GAP_2; pfam14312 357808013801 FG-GAP repeat; Region: FG-GAP_2; pfam14312 357808013802 FG-GAP repeat; Region: FG-GAP_2; pfam14312 357808013803 AAA ATPase domain; Region: AAA_16; pfam13191 357808013804 AAA domain; Region: AAA_22; pfam13401 357808013805 Walker A motif; other site 357808013806 ATP binding site [chemical binding]; other site 357808013807 Walker B motif; other site 357808013808 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357808013809 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 357808013810 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 357808013811 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 357808013812 putative FMN binding site [chemical binding]; other site 357808013813 NADPH bind site [chemical binding]; other site 357808013814 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 357808013815 Peptidase family M23; Region: Peptidase_M23; pfam01551 357808013816 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 357808013817 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808013818 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 357808013819 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357808013820 GAF domain; Region: GAF_3; pfam13492 357808013821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 357808013822 Histidine kinase; Region: HisKA_2; pfam07568 357808013823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357808013824 Mg2+ binding site [ion binding]; other site 357808013825 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 357808013826 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 357808013827 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 357808013828 active site 357808013829 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079