-- dump date   	20140620_040800
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
383372000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
383372000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
383372000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372000004	Walker A motif; other site
383372000005	ATP binding site [chemical binding]; other site
383372000006	Walker B motif; other site
383372000007	arginine finger; other site
383372000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
383372000009	DnaA box-binding interface [nucleotide binding]; other site
383372000010	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
383372000011	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
383372000012	active site
383372000013	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
383372000014	HIT family signature motif; other site
383372000015	catalytic residue [active]
383372000016	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
383372000017	hypothetical protein; Provisional; Region: PRK08609
383372000018	active site
383372000019	primer binding site [nucleotide binding]; other site
383372000020	NTP  binding site [chemical binding]; other site
383372000021	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
383372000022	active site
383372000023	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
383372000024	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
383372000025	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
383372000026	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
383372000027	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
383372000028	dimer interface [polypeptide binding]; other site
383372000029	putative anticodon binding site; other site
383372000030	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
383372000031	motif 1; other site
383372000032	active site
383372000033	motif 2; other site
383372000034	motif 3; other site
383372000035	Fic/DOC family; Region: Fic; cl00960
383372000036	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372000037	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
383372000038	NAD(P) binding site [chemical binding]; other site
383372000039	active site
383372000040	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
383372000041	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
383372000042	putative acyl-acceptor binding pocket; other site
383372000043	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
383372000044	Ligand binding site; other site
383372000045	Putative Catalytic site; other site
383372000046	DXD motif; other site
383372000047	Putative zinc-finger; Region: zf-HC2; pfam13490
383372000048	Transcriptional regulator [Transcription]; Region: LytR; COG1316
383372000049	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
383372000050	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
383372000051	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
383372000052	Mg++ binding site [ion binding]; other site
383372000053	putative catalytic motif [active]
383372000054	substrate binding site [chemical binding]; other site
383372000055	BioY family; Region: BioY; pfam02632
383372000056	acetylornithine deacetylase; Validated; Region: PRK06915
383372000057	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
383372000058	metal binding site [ion binding]; metal-binding site
383372000059	dimer interface [polypeptide binding]; other site
383372000060	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
383372000061	Amidinotransferase; Region: Amidinotransf; pfam02274
383372000062	Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751
383372000063	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
383372000064	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
383372000065	Zn binding site [ion binding]; other site
383372000066	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
383372000067	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
383372000068	Zn binding site [ion binding]; other site
383372000069	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
383372000070	putative cation:proton antiport protein; Provisional; Region: PRK10669
383372000071	TrkA-N domain; Region: TrkA_N; pfam02254
383372000072	TrkA-C domain; Region: TrkA_C; pfam02080
383372000073	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
383372000074	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372000075	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372000076	DNA binding residues [nucleotide binding]
383372000077	Putative zinc-finger; Region: zf-HC2; pfam13490
383372000078	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
383372000079	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
383372000080	dimer interface [polypeptide binding]; other site
383372000081	ssDNA binding site [nucleotide binding]; other site
383372000082	tetramer (dimer of dimers) interface [polypeptide binding]; other site
383372000083	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372000084	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372000085	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372000086	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372000087	S-adenosylmethionine binding site [chemical binding]; other site
383372000088	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
383372000089	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
383372000090	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
383372000091	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
383372000092	Substrate-binding site [chemical binding]; other site
383372000093	Substrate specificity [chemical binding]; other site
383372000094	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
383372000095	hydrophobic ligand binding site; other site
383372000096	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
383372000097	cyclase homology domain; Region: CHD; cd07302
383372000098	nucleotidyl binding site; other site
383372000099	metal binding site [ion binding]; metal-binding site
383372000100	dimer interface [polypeptide binding]; other site
383372000101	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000102	binding surface
383372000103	TPR repeat; Region: TPR_11; pfam13414
383372000104	TPR motif; other site
383372000105	TPR repeat; Region: TPR_11; pfam13414
383372000106	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
383372000107	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
383372000108	active site
383372000109	multimer interface [polypeptide binding]; other site
383372000110	Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934
383372000111	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
383372000112	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
383372000113	VanW like protein; Region: VanW; pfam04294
383372000114	G5 domain; Region: G5; pfam07501
383372000115	hypothetical protein; Reviewed; Region: PRK00024
383372000116	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
383372000117	MPN+ (JAMM) motif; other site
383372000118	Zinc-binding site [ion binding]; other site
383372000119	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
383372000120	Peptidase family M23; Region: Peptidase_M23; pfam01551
383372000121	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
383372000122	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
383372000123	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
383372000124	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
383372000125	NAD(P) binding site [chemical binding]; other site
383372000126	catalytic residues [active]
383372000127	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
383372000128	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
383372000129	DNA-binding site [nucleotide binding]; DNA binding site
383372000130	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
383372000131	active site
383372000132	catalytic residues [active]
383372000133	DNA binding site [nucleotide binding]
383372000134	Int/Topo IB signature motif; other site
383372000135	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
383372000136	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
383372000137	NAD binding site [chemical binding]; other site
383372000138	substrate binding site [chemical binding]; other site
383372000139	active site
383372000140	glycyl-tRNA synthetase; Provisional; Region: PRK14894
383372000141	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
383372000142	dimer interface [polypeptide binding]; other site
383372000143	motif 1; other site
383372000144	active site
383372000145	motif 2; other site
383372000146	motif 3; other site
383372000147	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
383372000148	anticodon binding site; other site
383372000149	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
383372000150	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
383372000151	active site
383372000152	DNA binding site [nucleotide binding]
383372000153	Int/Topo IB signature motif; other site
383372000154	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
383372000155	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
383372000156	FMN binding site [chemical binding]; other site
383372000157	active site
383372000158	catalytic residues [active]
383372000159	substrate binding site [chemical binding]; other site
383372000160	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
383372000161	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
383372000162	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
383372000163	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
383372000164	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
383372000165	YacP-like NYN domain; Region: NYN_YacP; cl01491
383372000166	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
383372000167	active site
383372000168	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
383372000169	dimerization interface [polypeptide binding]; other site
383372000170	Radical SAM superfamily; Region: Radical_SAM; pfam04055
383372000171	threonine dehydratase; Provisional; Region: PRK08198
383372000172	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
383372000173	tetramer interface [polypeptide binding]; other site
383372000174	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372000175	catalytic residue [active]
383372000176	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
383372000177	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
383372000178	HEAT repeats; Region: HEAT_2; pfam13646
383372000179	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
383372000180	DNA binding site [nucleotide binding]
383372000181	Bacterial transcriptional activator domain; Region: BTAD; smart01043
383372000182	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
383372000183	MutS domain III; Region: MutS_III; pfam05192
383372000184	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
383372000185	Walker A/P-loop; other site
383372000186	ATP binding site [chemical binding]; other site
383372000187	Q-loop/lid; other site
383372000188	ABC transporter signature motif; other site
383372000189	Walker B; other site
383372000190	D-loop; other site
383372000191	H-loop/switch region; other site
383372000192	Smr domain; Region: Smr; pfam01713
383372000193	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
383372000194	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
383372000195	YcxB-like protein; Region: YcxB; pfam14317
383372000196	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
383372000197	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
383372000198	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
383372000199	NodB motif; other site
383372000200	active site
383372000201	catalytic site [active]
383372000202	metal binding site [ion binding]; metal-binding site
383372000203	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
383372000204	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
383372000205	Catalytic GIY-YIG domain of type II restriction enzyme R.Cfr42I and similar proteins; Region: GIY-YIG_RE_Cfr42I; cd10453
383372000206	GIY-YIG motif/motif A; other site
383372000207	putative active site [active]
383372000208	putative metal binding site [ion binding]; other site
383372000209	Methyltransferase domain; Region: Methyltransf_26; pfam13659
383372000210	AAA-like domain; Region: AAA_10; pfam12846
383372000211	Helix-turn-helix domain; Region: HTH_17; pfam12728
383372000212	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
383372000213	ADP-ribose binding site [chemical binding]; other site
383372000214	enolase; Provisional; Region: eno; PRK00077
383372000215	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
383372000216	dimer interface [polypeptide binding]; other site
383372000217	metal binding site [ion binding]; metal-binding site
383372000218	substrate binding pocket [chemical binding]; other site
383372000219	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
383372000220	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
383372000221	DRTGG domain; Region: DRTGG; pfam07085
383372000222	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
383372000223	CoA binding domain; Region: CoA_binding_2; pfam13380
383372000224	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
383372000225	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
383372000226	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
383372000227	leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396
383372000228	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
383372000229	HIGH motif; other site
383372000230	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
383372000231	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
383372000232	active site
383372000233	KMSKS motif; other site
383372000234	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
383372000235	tRNA binding surface [nucleotide binding]; other site
383372000236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
383372000237	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
383372000238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
383372000239	Uncharacterized conserved protein [Function unknown]; Region: COG2442
383372000240	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
383372000241	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
383372000242	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
383372000243	active site
383372000244	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
383372000245	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
383372000246	active site
383372000247	catalytic tetrad [active]
383372000248	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
383372000249	elongation factor G; Reviewed; Region: PRK12740
383372000250	G1 box; other site
383372000251	putative GEF interaction site [polypeptide binding]; other site
383372000252	GTP/Mg2+ binding site [chemical binding]; other site
383372000253	Switch I region; other site
383372000254	G2 box; other site
383372000255	G3 box; other site
383372000256	Switch II region; other site
383372000257	G4 box; other site
383372000258	G5 box; other site
383372000259	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
383372000260	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
383372000261	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
383372000262	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
383372000263	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
383372000264	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
383372000265	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372000266	active site
383372000267	NTP binding site [chemical binding]; other site
383372000268	metal binding triad [ion binding]; metal-binding site
383372000269	antibiotic binding site [chemical binding]; other site
383372000270	Uncharacterized conserved protein [Function unknown]; Region: COG2361
383372000271	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
383372000272	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
383372000273	putative [4Fe-4S] binding site [ion binding]; other site
383372000274	putative molybdopterin cofactor binding site [chemical binding]; other site
383372000275	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
383372000276	putative molybdopterin cofactor binding site; other site
383372000277	shikimate kinase; Reviewed; Region: aroK; PRK00131
383372000278	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
383372000279	ADP binding site [chemical binding]; other site
383372000280	magnesium binding site [ion binding]; other site
383372000281	putative shikimate binding site; other site
383372000282	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
383372000283	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
383372000284	active site
383372000285	dimer interface [polypeptide binding]; other site
383372000286	metal binding site [ion binding]; metal-binding site
383372000287	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
383372000288	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372000289	active site
383372000290	NTP binding site [chemical binding]; other site
383372000291	metal binding triad [ion binding]; metal-binding site
383372000292	antibiotic binding site [chemical binding]; other site
383372000293	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372000294	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
383372000295	Protein phosphatase 2C; Region: PP2C; pfam00481
383372000296	active site
383372000297	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
383372000298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372000299	ATP binding site [chemical binding]; other site
383372000300	Mg2+ binding site [ion binding]; other site
383372000301	G-X-G motif; other site
383372000302	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
383372000303	ATP binding site [chemical binding]; other site
383372000304	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
383372000305	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
383372000306	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
383372000307	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
383372000308	FeoA domain; Region: FeoA; pfam04023
383372000309	Protein of unknown function (DUF952); Region: DUF952; pfam06108
383372000310	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
383372000311	uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774
383372000312	putative N- and C-terminal domain interface [polypeptide binding]; other site
383372000313	putative active site [active]
383372000314	putative MgATP binding site [chemical binding]; other site
383372000315	catalytic site [active]
383372000316	metal binding site [ion binding]; metal-binding site
383372000317	putative carbohydrate binding site [chemical binding]; other site
383372000318	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
383372000319	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372000320	NAD(P) binding site [chemical binding]; other site
383372000321	active site
383372000322	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
383372000323	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
383372000324	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
383372000325	polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132
383372000326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372000327	dimer interface [polypeptide binding]; other site
383372000328	conserved gate region; other site
383372000329	putative PBP binding loops; other site
383372000330	ABC-ATPase subunit interface; other site
383372000331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372000332	ABC-ATPase subunit interface; other site
383372000333	putative PBP binding loops; other site
383372000334	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
383372000335	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
383372000336	Walker A/P-loop; other site
383372000337	ATP binding site [chemical binding]; other site
383372000338	Q-loop/lid; other site
383372000339	ABC transporter signature motif; other site
383372000340	Walker B; other site
383372000341	D-loop; other site
383372000342	H-loop/switch region; other site
383372000343	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
383372000344	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
383372000345	MgtC family; Region: MgtC; pfam02308
383372000346	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
383372000347	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
383372000348	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
383372000349	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
383372000350	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372000351	dimer interface [polypeptide binding]; other site
383372000352	conserved gate region; other site
383372000353	putative PBP binding loops; other site
383372000354	ABC-ATPase subunit interface; other site
383372000355	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372000356	dimer interface [polypeptide binding]; other site
383372000357	putative PBP binding loops; other site
383372000358	ABC-ATPase subunit interface; other site
383372000359	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
383372000360	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
383372000361	inhibitor-cofactor binding pocket; inhibition site
383372000362	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372000363	catalytic residue [active]
383372000364	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372000365	putative active site [active]
383372000366	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372000367	Coenzyme A binding pocket [chemical binding]; other site
383372000368	histidyl-tRNA synthetase; Region: hisS; TIGR00442
383372000369	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
383372000370	dimer interface [polypeptide binding]; other site
383372000371	motif 1; other site
383372000372	active site
383372000373	motif 2; other site
383372000374	motif 3; other site
383372000375	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
383372000376	anticodon binding site; other site
383372000377	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
383372000378	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
383372000379	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
383372000380	ATP cone domain; Region: ATP-cone; pfam03477
383372000381	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
383372000382	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505
383372000383	Uncharacterized conserved protein [Function unknown]; Region: COG1262
383372000384	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
383372000385	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372000386	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372000387	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
383372000388	conserved cys residue [active]
383372000389	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372000390	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
383372000391	putative active site [active]
383372000392	heme pocket [chemical binding]; other site
383372000393	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372000394	putative active site [active]
383372000395	heme pocket [chemical binding]; other site
383372000396	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372000397	Amino acid permease; Region: AA_permease_2; pfam13520
383372000398	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
383372000399	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
383372000400	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
383372000401	active site
383372000402	metal binding site [ion binding]; metal-binding site
383372000403	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372000404	putative active site [active]
383372000405	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
383372000406	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
383372000407	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372000408	motif II; other site
383372000409	Predicted transcriptional regulators [Transcription]; Region: COG1378
383372000410	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
383372000411	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
383372000412	C-terminal domain interface [polypeptide binding]; other site
383372000413	sugar binding site [chemical binding]; other site
383372000414	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
383372000415	active site
383372000416	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
383372000417	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372000418	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
383372000419	active site
383372000420	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372000421	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372000422	Probable Catalytic site; other site
383372000423	metal-binding site
383372000424	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
383372000425	Putative transmembrane protein; Region: Tmp39; pfam10271
383372000426	Methyltransferase domain; Region: Methyltransf_11; pfam08241
383372000427	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372000428	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372000429	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372000430	S-adenosylmethionine binding site [chemical binding]; other site
383372000431	Methyltransferase domain; Region: Methyltransf_24; pfam13578
383372000432	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372000433	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372000434	DNA binding residues [nucleotide binding]
383372000435	dimerization interface [polypeptide binding]; other site
383372000436	Kelch domain; Region: Kelch; smart00612
383372000437	Kelch domain; Region: Kelch; smart00612
383372000438	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
383372000439	Kelch domain; Region: Kelch; smart00612
383372000440	Kelch motif; Region: Kelch_1; pfam01344
383372000441	Galactose oxidase, central domain; Region: Kelch_3; cl02701
383372000442	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
383372000443	Winged helix-turn helix; Region: HTH_33; pfam13592
383372000444	DDE superfamily endonuclease; Region: DDE_3; pfam13358
383372000445	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
383372000446	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
383372000447	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
383372000448	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
383372000449	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
383372000450	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
383372000451	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372000452	NAD(P) binding site [chemical binding]; other site
383372000453	active site
383372000454	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
383372000455	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
383372000456	dimer interface [polypeptide binding]; other site
383372000457	substrate binding site [chemical binding]; other site
383372000458	metal binding site [ion binding]; metal-binding site
383372000459	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
383372000460	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
383372000461	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372000462	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372000463	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372000464	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372000465	GAF domain; Region: GAF_2; pfam13185
383372000466	GAF domain; Region: GAF_3; pfam13492
383372000467	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372000468	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372000469	putative active site [active]
383372000470	heme pocket [chemical binding]; other site
383372000471	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372000472	dimer interface [polypeptide binding]; other site
383372000473	phosphorylation site [posttranslational modification]
383372000474	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372000475	ATP binding site [chemical binding]; other site
383372000476	Mg2+ binding site [ion binding]; other site
383372000477	G-X-G motif; other site
383372000478	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
383372000479	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
383372000480	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
383372000481	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
383372000482	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
383372000483	substrate binding site [chemical binding]; other site
383372000484	ATP binding site [chemical binding]; other site
383372000485	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
383372000486	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
383372000487	homotetramer interface [polypeptide binding]; other site
383372000488	ligand binding site [chemical binding]; other site
383372000489	catalytic site [active]
383372000490	NAD binding site [chemical binding]; other site
383372000491	S-adenosylmethionine synthetase; Validated; Region: PRK05250
383372000492	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
383372000493	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
383372000494	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
383372000495	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
383372000496	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
383372000497	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
383372000498	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
383372000499	Walker A/P-loop; other site
383372000500	ATP binding site [chemical binding]; other site
383372000501	Q-loop/lid; other site
383372000502	ABC transporter signature motif; other site
383372000503	Walker B; other site
383372000504	D-loop; other site
383372000505	H-loop/switch region; other site
383372000506	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
383372000507	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
383372000508	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372000509	dimer interface [polypeptide binding]; other site
383372000510	conserved gate region; other site
383372000511	putative PBP binding loops; other site
383372000512	ABC-ATPase subunit interface; other site
383372000513	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372000514	dimer interface [polypeptide binding]; other site
383372000515	conserved gate region; other site
383372000516	putative PBP binding loops; other site
383372000517	ABC-ATPase subunit interface; other site
383372000518	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
383372000519	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
383372000520	RNA binding surface [nucleotide binding]; other site
383372000521	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
383372000522	active site
383372000523	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
383372000524	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
383372000525	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
383372000526	DNA protecting protein DprA; Region: dprA; TIGR00732
383372000527	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372000528	S-adenosylmethionine binding site [chemical binding]; other site
383372000529	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
383372000530	ABC1 family; Region: ABC1; cl17513
383372000531	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
383372000532	catalytic core [active]
383372000533	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
383372000534	cobalamin synthase; Reviewed; Region: cobS; PRK00235
383372000535	DinB superfamily; Region: DinB_2; pfam12867
383372000536	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
383372000537	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
383372000538	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
383372000539	hypothetical protein; Provisional; Region: PRK07233
383372000540	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
383372000541	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
383372000542	extended (e) SDRs; Region: SDR_e; cd08946
383372000543	NAD(P) binding site [chemical binding]; other site
383372000544	active site
383372000545	substrate binding site [chemical binding]; other site
383372000546	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
383372000547	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
383372000548	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
383372000549	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
383372000550	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558
383372000551	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
383372000552	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
383372000553	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
383372000554	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
383372000555	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
383372000556	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
383372000557	metal binding site [ion binding]; metal-binding site
383372000558	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
383372000559	peptide binding site [polypeptide binding]; other site
383372000560	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
383372000561	dimer interface [polypeptide binding]; other site
383372000562	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
383372000563	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
383372000564	active site
383372000565	PHP Thumb interface [polypeptide binding]; other site
383372000566	metal binding site [ion binding]; metal-binding site
383372000567	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
383372000568	generic binding surface II; other site
383372000569	generic binding surface I; other site
383372000570	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
383372000571	Catalytic site; other site
383372000572	Lamin Tail Domain; Region: LTD; pfam00932
383372000573	histidinol-phosphate aminotransferase; Provisional; Region: PLN03026
383372000574	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
383372000575	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372000576	homodimer interface [polypeptide binding]; other site
383372000577	catalytic residue [active]
383372000578	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
383372000579	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
383372000580	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
383372000581	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
383372000582	Ligand binding site; other site
383372000583	Putative Catalytic site; other site
383372000584	DXD motif; other site
383372000585	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
383372000586	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372000587	NAD(P) binding site [chemical binding]; other site
383372000588	active site
383372000589	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
383372000590	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
383372000591	inhibitor-cofactor binding pocket; inhibition site
383372000592	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372000593	catalytic residue [active]
383372000594	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
383372000595	OsmC-like protein; Region: OsmC; pfam02566
383372000596	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
383372000597	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
383372000598	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
383372000599	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
383372000600	active site
383372000601	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
383372000602	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
383372000603	putative substrate binding site [chemical binding]; other site
383372000604	putative ATP binding site [chemical binding]; other site
383372000605	MoxR-like ATPases [General function prediction only]; Region: COG0714
383372000606	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372000607	Walker A motif; other site
383372000608	ATP binding site [chemical binding]; other site
383372000609	Walker B motif; other site
383372000610	arginine finger; other site
383372000611	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372000612	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372000613	active site
383372000614	phosphorylation site [posttranslational modification]
383372000615	intermolecular recognition site; other site
383372000616	dimerization interface [polypeptide binding]; other site
383372000617	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372000618	DNA binding residues [nucleotide binding]
383372000619	dimerization interface [polypeptide binding]; other site
383372000620	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
383372000621	amidase catalytic site [active]
383372000622	Zn binding residues [ion binding]; other site
383372000623	substrate binding site [chemical binding]; other site
383372000624	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
383372000625	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000626	TPR motif; other site
383372000627	binding surface
383372000628	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000629	binding surface
383372000630	TPR motif; other site
383372000631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000632	binding surface
383372000633	TPR motif; other site
383372000634	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000635	TPR motif; other site
383372000636	binding surface
383372000637	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000638	binding surface
383372000639	TPR motif; other site
383372000640	Tetratricopeptide repeat; Region: TPR_16; pfam13432
383372000641	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000642	binding surface
383372000643	TPR motif; other site
383372000644	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000645	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000646	TPR motif; other site
383372000647	binding surface
383372000648	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000649	binding surface
383372000650	TPR motif; other site
383372000651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000652	TPR motif; other site
383372000653	binding surface
383372000654	TPR repeat; Region: TPR_11; pfam13414
383372000655	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000656	binding surface
383372000657	TPR motif; other site
383372000658	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
383372000659	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000660	TPR motif; other site
383372000661	binding surface
383372000662	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372000663	binding surface
383372000664	TPR motif; other site
383372000665	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372000666	putative active site [active]
383372000667	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372000668	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372000669	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
383372000670	nudix motif; other site
383372000671	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
383372000672	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
383372000673	putative active site [active]
383372000674	putative metal binding site [ion binding]; other site
383372000675	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
383372000676	active site
383372000677	catalytic triad [active]
383372000678	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372000679	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372000680	phosphopeptide binding site; other site
383372000681	Haem-binding domain; Region: Haem_bd; pfam14376
383372000682	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
383372000683	ApbE family; Region: ApbE; pfam02424
383372000684	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
383372000685	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
383372000686	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372000687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372000688	active site
383372000689	phosphorylation site [posttranslational modification]
383372000690	intermolecular recognition site; other site
383372000691	dimerization interface [polypeptide binding]; other site
383372000692	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372000693	DNA binding site [nucleotide binding]
383372000694	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372000695	dimer interface [polypeptide binding]; other site
383372000696	phosphorylation site [posttranslational modification]
383372000697	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372000698	ATP binding site [chemical binding]; other site
383372000699	Mg2+ binding site [ion binding]; other site
383372000700	G-X-G motif; other site
383372000701	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
383372000702	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
383372000703	oligomer interface [polypeptide binding]; other site
383372000704	active site
383372000705	metal binding site [ion binding]; metal-binding site
383372000706	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
383372000707	Proline racemase; Region: Pro_racemase; pfam05544
383372000708	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
383372000709	Glyco_18 domain; Region: Glyco_18; smart00636
383372000710	active site
383372000711	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
383372000712	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
383372000713	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372000714	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372000715	DNA binding residues [nucleotide binding]
383372000716	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
383372000717	PhoU domain; Region: PhoU; pfam01895
383372000718	PhoU domain; Region: PhoU; pfam01895
383372000719	acylphosphatase; Provisional; Region: PRK14444
383372000720	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
383372000721	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
383372000722	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
383372000723	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
383372000724	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
383372000725	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
383372000726	active site
383372000727	Response regulator receiver domain; Region: Response_reg; pfam00072
383372000728	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372000729	active site
383372000730	phosphorylation site [posttranslational modification]
383372000731	intermolecular recognition site; other site
383372000732	dimerization interface [polypeptide binding]; other site
383372000733	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372000734	dimer interface [polypeptide binding]; other site
383372000735	phosphorylation site [posttranslational modification]
383372000736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372000737	ATP binding site [chemical binding]; other site
383372000738	Mg2+ binding site [ion binding]; other site
383372000739	G-X-G motif; other site
383372000740	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
383372000741	Fe-S cluster binding site [ion binding]; other site
383372000742	active site
383372000743	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
383372000744	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
383372000745	active site
383372000746	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
383372000747	Zn binding site [ion binding]; other site
383372000748	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
383372000749	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
383372000750	ligand binding site [chemical binding]; other site
383372000751	flexible hinge region; other site
383372000752	Ferredoxin [Energy production and conversion]; Region: COG1146
383372000753	4Fe-4S binding domain; Region: Fer4; cl02805
383372000754	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
383372000755	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
383372000756	Zn2+ binding site [ion binding]; other site
383372000757	Mg2+ binding site [ion binding]; other site
383372000758	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
383372000759	DNA primase; Validated; Region: dnaG; PRK05667
383372000760	CHC2 zinc finger; Region: zf-CHC2; pfam01807
383372000761	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
383372000762	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
383372000763	active site
383372000764	metal binding site [ion binding]; metal-binding site
383372000765	interdomain interaction site; other site
383372000766	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
383372000767	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
383372000768	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
383372000769	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
383372000770	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372000771	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
383372000772	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372000773	DNA binding residues [nucleotide binding]
383372000774	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
383372000775	HSP70 interaction site [polypeptide binding]; other site
383372000776	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
383372000777	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
383372000778	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
383372000779	GTP binding site; other site
383372000780	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
383372000781	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
383372000782	ligand binding site [chemical binding]; other site
383372000783	NAD binding site [chemical binding]; other site
383372000784	dimerization interface [polypeptide binding]; other site
383372000785	catalytic site [active]
383372000786	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
383372000787	putative L-serine binding site [chemical binding]; other site
383372000788	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
383372000789	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
383372000790	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
383372000791	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
383372000792	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
383372000793	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
383372000794	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
383372000795	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
383372000796	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
383372000797	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
383372000798	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
383372000799	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
383372000800	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
383372000801	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
383372000802	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
383372000803	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
383372000804	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
383372000805	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
383372000806	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
383372000807	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
383372000808	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
383372000809	TAP-like protein; Region: Abhydrolase_4; pfam08386
383372000810	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
383372000811	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
383372000812	FtsX-like permease family; Region: FtsX; pfam02687
383372000813	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
383372000814	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
383372000815	Walker A/P-loop; other site
383372000816	ATP binding site [chemical binding]; other site
383372000817	Q-loop/lid; other site
383372000818	ABC transporter signature motif; other site
383372000819	Walker B; other site
383372000820	D-loop; other site
383372000821	H-loop/switch region; other site
383372000822	HlyD family secretion protein; Region: HlyD_3; pfam13437
383372000823	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
383372000824	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
383372000825	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
383372000826	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
383372000827	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
383372000828	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
383372000829	NAD(P) binding site [chemical binding]; other site
383372000830	catalytic residues [active]
383372000831	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
383372000832	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
383372000833	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
383372000834	non-specific DNA binding site [nucleotide binding]; other site
383372000835	salt bridge; other site
383372000836	sequence-specific DNA binding site [nucleotide binding]; other site
383372000837	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
383372000838	lipoprotein signal peptidase; Provisional; Region: PRK14790
383372000839	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
383372000840	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
383372000841	RNA binding surface [nucleotide binding]; other site
383372000842	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
383372000843	active site
383372000844	malate dehydrogenase; Reviewed; Region: PRK06223
383372000845	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
383372000846	NAD(P) binding site [chemical binding]; other site
383372000847	dimer interface [polypeptide binding]; other site
383372000848	tetramer (dimer of dimers) interface [polypeptide binding]; other site
383372000849	substrate binding site [chemical binding]; other site
383372000850	GAF domain; Region: GAF; pfam01590
383372000851	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
383372000852	Histidine kinase; Region: HisKA_3; pfam07730
383372000853	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372000854	ATP binding site [chemical binding]; other site
383372000855	Mg2+ binding site [ion binding]; other site
383372000856	G-X-G motif; other site
383372000857	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
383372000858	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
383372000859	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
383372000860	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
383372000861	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
383372000862	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
383372000863	phosphodiesterase YaeI; Provisional; Region: PRK11340
383372000864	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
383372000865	putative active site [active]
383372000866	putative metal binding site [ion binding]; other site
383372000867	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
383372000868	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
383372000869	catalytic core [active]
383372000870	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
383372000871	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
383372000872	ligand binding site [chemical binding]; other site
383372000873	flexible hinge region; other site
383372000874	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
383372000875	putative switch regulator; other site
383372000876	non-specific DNA interactions [nucleotide binding]; other site
383372000877	DNA binding site [nucleotide binding]
383372000878	sequence specific DNA binding site [nucleotide binding]; other site
383372000879	putative cAMP binding site [chemical binding]; other site
383372000880	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
383372000881	TIGR03663 family protein; Region: TIGR03663
383372000882	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
383372000883	NHL repeat; Region: NHL; pfam01436
383372000884	Uncharacterized conserved protein [Function unknown]; Region: COG3391
383372000885	NHL repeat; Region: NHL; pfam01436
383372000886	NHL repeat; Region: NHL; pfam01436
383372000887	NHL repeat; Region: NHL; pfam01436
383372000888	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
383372000889	metal-binding site [ion binding]
383372000890	multifunctional aminopeptidase A; Provisional; Region: PRK00913
383372000891	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
383372000892	interface (dimer of trimers) [polypeptide binding]; other site
383372000893	Substrate-binding/catalytic site; other site
383372000894	Zn-binding sites [ion binding]; other site
383372000895	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
383372000896	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
383372000897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372000898	active site
383372000899	phosphorylation site [posttranslational modification]
383372000900	intermolecular recognition site; other site
383372000901	dimerization interface [polypeptide binding]; other site
383372000902	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
383372000903	Zn2+ binding site [ion binding]; other site
383372000904	Mg2+ binding site [ion binding]; other site
383372000905	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
383372000906	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
383372000907	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372000908	homodimer interface [polypeptide binding]; other site
383372000909	catalytic residue [active]
383372000910	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
383372000911	active site
383372000912	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
383372000913	active site
383372000914	GTP cyclohydrolase I; Provisional; Region: PLN03044
383372000915	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
383372000916	homodecamer interface [polypeptide binding]; other site
383372000917	active site
383372000918	putative catalytic site residues [active]
383372000919	zinc binding site [ion binding]; other site
383372000920	GTP-CH-I/GFRP interaction surface; other site
383372000921	short chain dehydrogenase; Provisional; Region: PRK07454
383372000922	classical (c) SDRs; Region: SDR_c; cd05233
383372000923	NAD(P) binding site [chemical binding]; other site
383372000924	active site
383372000925	Predicted transcriptional regulator [Transcription]; Region: COG2345
383372000926	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
383372000927	putative Zn2+ binding site [ion binding]; other site
383372000928	putative DNA binding site [nucleotide binding]; other site
383372000929	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
383372000930	FeS assembly ATPase SufC; Region: sufC; TIGR01978
383372000931	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
383372000932	Walker A/P-loop; other site
383372000933	ATP binding site [chemical binding]; other site
383372000934	Q-loop/lid; other site
383372000935	ABC transporter signature motif; other site
383372000936	Walker B; other site
383372000937	D-loop; other site
383372000938	H-loop/switch region; other site
383372000939	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
383372000940	FeS assembly protein SufD; Region: sufD; TIGR01981
383372000941	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
383372000942	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
383372000943	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
383372000944	catalytic residue [active]
383372000945	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
383372000946	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
383372000947	trimerization site [polypeptide binding]; other site
383372000948	active site
383372000949	FeS assembly protein SufB; Region: sufB; TIGR01980
383372000950	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
383372000951	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
383372000952	[2Fe-2S] cluster binding site [ion binding]; other site
383372000953	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
383372000954	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
383372000955	active site residue [active]
383372000956	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
383372000957	active site residue [active]
383372000958	Fe-S metabolism associated domain; Region: SufE; cl00951
383372000959	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
383372000960	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
383372000961	trimerization site [polypeptide binding]; other site
383372000962	active site
383372000963	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
383372000964	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
383372000965	dimer interface [polypeptide binding]; other site
383372000966	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372000967	catalytic residue [active]
383372000968	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
383372000969	MPN+ (JAMM) motif; other site
383372000970	Zinc-binding site [ion binding]; other site
383372000971	Molybdopterin converting factor, small subunit [Coenzyme metabolism]; Region: MoaD; COG1977
383372000972	charged pocket; other site
383372000973	hydrophobic patch; other site
383372000974	hypothetical protein; Validated; Region: PRK07411
383372000975	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
383372000976	ATP binding site [chemical binding]; other site
383372000977	substrate interface [chemical binding]; other site
383372000978	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
383372000979	active site residue [active]
383372000980	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
383372000981	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
383372000982	peptide binding site [polypeptide binding]; other site
383372000983	dimer interface [polypeptide binding]; other site
383372000984	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
383372000985	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
383372000986	active site residue [active]
383372000987	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
383372000988	active site residue [active]
383372000989	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
383372000990	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
383372000991	active site
383372000992	HIGH motif; other site
383372000993	nucleotide binding site [chemical binding]; other site
383372000994	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
383372000995	active site
383372000996	KMSKS motif; other site
383372000997	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
383372000998	tRNA binding surface [nucleotide binding]; other site
383372000999	anticodon binding site; other site
383372001000	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372001001	FeS/SAM binding site; other site
383372001002	DNA gyrase subunit A; Validated; Region: PRK05560
383372001003	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
383372001004	CAP-like domain; other site
383372001005	active site
383372001006	primary dimer interface [polypeptide binding]; other site
383372001007	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
383372001008	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
383372001009	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
383372001010	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
383372001011	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
383372001012	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
383372001013	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
383372001014	active site
383372001015	metal binding site [ion binding]; metal-binding site
383372001016	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
383372001017	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
383372001018	Active Sites [active]
383372001019	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
383372001020	active site
383372001021	pantoate--beta-alanine ligase; Region: panC; TIGR00018
383372001022	Pantoate-beta-alanine ligase; Region: PanC; cd00560
383372001023	active site
383372001024	ATP-binding site [chemical binding]; other site
383372001025	pantoate-binding site; other site
383372001026	HXXH motif; other site
383372001027	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
383372001028	oligomerization interface [polypeptide binding]; other site
383372001029	active site
383372001030	metal binding site [ion binding]; metal-binding site
383372001031	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
383372001032	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372001033	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372001034	active site
383372001035	ATP binding site [chemical binding]; other site
383372001036	substrate binding site [chemical binding]; other site
383372001037	activation loop (A-loop); other site
383372001038	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
383372001039	Bacterial transcriptional activator domain; Region: BTAD; smart01043
383372001040	AAA ATPase domain; Region: AAA_16; pfam13191
383372001041	Predicted ATPase [General function prediction only]; Region: COG3899
383372001042	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
383372001043	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
383372001044	putative GEF interaction site [polypeptide binding]; other site
383372001045	G1 box; other site
383372001046	GTP/Mg2+ binding site [chemical binding]; other site
383372001047	Switch I region; other site
383372001048	G2 box; other site
383372001049	G3 box; other site
383372001050	Switch II region; other site
383372001051	G4 box; other site
383372001052	G5 box; other site
383372001053	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
383372001054	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
383372001055	Acyl CoA binding protein; Region: ACBP; pfam00887
383372001056	acyl-CoA binding pocket [chemical binding]; other site
383372001057	CoA binding site [chemical binding]; other site
383372001058	Asparaginase [Amino acid transport and metabolism]; Region: COG1446
383372001059	active site
383372001060	dimer interface [polypeptide binding]; other site
383372001061	catalytic nucleophile [active]
383372001062	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
383372001063	Protein of unknown function (DUF4013); Region: DUF4013; pfam13197
383372001064	Protein of unknown function (DUF4013); Region: DUF4013; pfam13197
383372001065	competence damage-inducible protein A; Provisional; Region: PRK00549
383372001066	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
383372001067	putative MPT binding site; other site
383372001068	Competence-damaged protein; Region: CinA; cl00666
383372001069	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
383372001070	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
383372001071	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
383372001072	active site
383372001073	dimer interface [polypeptide binding]; other site
383372001074	motif 1; other site
383372001075	motif 2; other site
383372001076	motif 3; other site
383372001077	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
383372001078	anticodon binding site; other site
383372001079	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
383372001080	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
383372001081	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
383372001082	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
383372001083	Na binding site [ion binding]; other site
383372001084	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372001085	dimerization interface [polypeptide binding]; other site
383372001086	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372001087	dimer interface [polypeptide binding]; other site
383372001088	phosphorylation site [posttranslational modification]
383372001089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372001090	ATP binding site [chemical binding]; other site
383372001091	Mg2+ binding site [ion binding]; other site
383372001092	G-X-G motif; other site
383372001093	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372001094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372001095	active site
383372001096	phosphorylation site [posttranslational modification]
383372001097	intermolecular recognition site; other site
383372001098	dimerization interface [polypeptide binding]; other site
383372001099	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372001100	DNA binding site [nucleotide binding]
383372001101	Bifunctional nuclease; Region: DNase-RNase; pfam02577
383372001102	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
383372001103	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
383372001104	P-loop; other site
383372001105	Magnesium ion binding site [ion binding]; other site
383372001106	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
383372001107	Magnesium ion binding site [ion binding]; other site
383372001108	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
383372001109	ParB-like nuclease domain; Region: ParBc; pfam02195
383372001110	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
383372001111	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
383372001112	substrate binding site [chemical binding]; other site
383372001113	ATP binding site [chemical binding]; other site
383372001114	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
383372001115	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
383372001116	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
383372001117	Walker A/P-loop; other site
383372001118	ATP binding site [chemical binding]; other site
383372001119	Q-loop/lid; other site
383372001120	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
383372001121	ABC transporter signature motif; other site
383372001122	Walker B; other site
383372001123	D-loop; other site
383372001124	H-loop/switch region; other site
383372001125	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
383372001126	O-Antigen ligase; Region: Wzy_C; cl04850
383372001127	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372001128	TPR motif; other site
383372001129	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372001130	binding surface
383372001131	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372001132	binding surface
383372001133	TPR motif; other site
383372001134	Membrane transport protein; Region: Mem_trans; cl09117
383372001135	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
383372001136	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
383372001137	DctM-like transporters; Region: DctM; pfam06808
383372001138	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
383372001139	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
383372001140	active site
383372001141	HIGH motif; other site
383372001142	nucleotide binding site [chemical binding]; other site
383372001143	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
383372001144	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
383372001145	active site
383372001146	KMSKS motif; other site
383372001147	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
383372001148	tRNA binding surface [nucleotide binding]; other site
383372001149	anticodon binding site; other site
383372001150	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
383372001151	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
383372001152	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372001153	NAD(P) binding site [chemical binding]; other site
383372001154	active site
383372001155	Transcriptional regulator [Transcription]; Region: LytR; COG1316
383372001156	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
383372001157	MviN-like protein; Region: MVIN; pfam03023
383372001158	bile acid transporter; Region: bass; TIGR00841
383372001159	Sodium Bile acid symporter family; Region: SBF; pfam01758
383372001160	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
383372001161	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
383372001162	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
383372001163	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
383372001164	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
383372001165	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
383372001166	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372001167	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
383372001168	Response regulator receiver domain; Region: Response_reg; pfam00072
383372001169	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372001170	active site
383372001171	phosphorylation site [posttranslational modification]
383372001172	intermolecular recognition site; other site
383372001173	dimerization interface [polypeptide binding]; other site
383372001174	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
383372001175	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372001176	Probable Catalytic site; other site
383372001177	metal-binding site
383372001178	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
383372001179	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
383372001180	putative metal binding site; other site
383372001181	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
383372001182	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372001183	Probable Catalytic site; other site
383372001184	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372001185	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372001186	active site
383372001187	ATP binding site [chemical binding]; other site
383372001188	substrate binding site [chemical binding]; other site
383372001189	activation loop (A-loop); other site
383372001190	TPR repeat; Region: TPR_11; pfam13414
383372001191	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372001192	binding surface
383372001193	TPR motif; other site
383372001194	TPR repeat; Region: TPR_11; pfam13414
383372001195	TPR repeat; Region: TPR_11; pfam13414
383372001196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372001197	binding surface
383372001198	TPR motif; other site
383372001199	TPR repeat; Region: TPR_11; pfam13414
383372001200	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
383372001201	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
383372001202	dimer interface [polypeptide binding]; other site
383372001203	active site
383372001204	ribonuclease III; Reviewed; Region: rnc; PRK00102
383372001205	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
383372001206	dimerization interface [polypeptide binding]; other site
383372001207	active site
383372001208	metal binding site [ion binding]; metal-binding site
383372001209	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
383372001210	dsRNA binding site [nucleotide binding]; other site
383372001211	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
383372001212	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372001213	NAD(P) binding site [chemical binding]; other site
383372001214	active site
383372001215	HEAT repeats; Region: HEAT_2; pfam13646
383372001216	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
383372001217	HEAT repeats; Region: HEAT_2; pfam13646
383372001218	protein binding surface [polypeptide binding]; other site
383372001219	HEAT repeats; Region: HEAT_2; pfam13646
383372001220	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
383372001221	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
383372001222	peptide binding site [polypeptide binding]; other site
383372001223	dimer interface [polypeptide binding]; other site
383372001224	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
383372001225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372001226	dimer interface [polypeptide binding]; other site
383372001227	conserved gate region; other site
383372001228	putative PBP binding loops; other site
383372001229	ABC-ATPase subunit interface; other site
383372001230	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
383372001231	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
383372001232	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372001233	dimer interface [polypeptide binding]; other site
383372001234	conserved gate region; other site
383372001235	putative PBP binding loops; other site
383372001236	ABC-ATPase subunit interface; other site
383372001237	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372001238	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372001239	active site
383372001240	ATP binding site [chemical binding]; other site
383372001241	substrate binding site [chemical binding]; other site
383372001242	activation loop (A-loop); other site
383372001243	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372001244	Double zinc ribbon; Region: DZR; pfam12773
383372001245	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
383372001246	nudix motif; other site
383372001247	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
383372001248	Isochorismatase family; Region: Isochorismatase; pfam00857
383372001249	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
383372001250	catalytic triad [active]
383372001251	conserved cis-peptide bond; other site
383372001252	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
383372001253	Part of AAA domain; Region: AAA_19; pfam13245
383372001254	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
383372001255	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
383372001256	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
383372001257	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
383372001258	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
383372001259	substrate binding pocket [chemical binding]; other site
383372001260	substrate-Mg2+ binding site; other site
383372001261	aspartate-rich region 1; other site
383372001262	aspartate-rich region 2; other site
383372001263	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
383372001264	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
383372001265	active site
383372001266	catalytic site [active]
383372001267	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
383372001268	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
383372001269	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
383372001270	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
383372001271	DNA methylase; Region: N6_N4_Mtase; cl17433
383372001272	DNA methylase; Region: N6_N4_Mtase; cl17433
383372001273	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
383372001274	four helix bundle protein; Region: TIGR02436
383372001275	DEAD-like helicases superfamily; Region: DEXDc; smart00487
383372001276	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
383372001277	ATP binding site [chemical binding]; other site
383372001278	putative Mg++ binding site [ion binding]; other site
383372001279	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
383372001280	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
383372001281	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
383372001282	DNA methylase; Region: N6_N4_Mtase; cl17433
383372001283	Restriction endonuclease BsobI; Region: Endonuc-BsobI; pfam09194
383372001284	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
383372001285	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
383372001286	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
383372001287	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
383372001288	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
383372001289	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
383372001290	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
383372001291	active site
383372001292	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
383372001293	acyl-activating enzyme (AAE) consensus motif; other site
383372001294	putative AMP binding site [chemical binding]; other site
383372001295	putative active site [active]
383372001296	putative CoA binding site [chemical binding]; other site
383372001297	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
383372001298	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
383372001299	acyl-activating enzyme (AAE) consensus motif; other site
383372001300	putative AMP binding site [chemical binding]; other site
383372001301	putative active site [active]
383372001302	putative CoA binding site [chemical binding]; other site
383372001303	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
383372001304	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
383372001305	TPP-binding site [chemical binding]; other site
383372001306	dimer interface [polypeptide binding]; other site
383372001307	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
383372001308	PYR/PP interface [polypeptide binding]; other site
383372001309	dimer interface [polypeptide binding]; other site
383372001310	TPP binding site [chemical binding]; other site
383372001311	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
383372001312	active site
383372001313	intersubunit interactions; other site
383372001314	catalytic residue [active]
383372001315	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
383372001316	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
383372001317	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372001318	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
383372001319	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372001320	DNA binding residues [nucleotide binding]
383372001321	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
383372001322	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
383372001323	Walker A/P-loop; other site
383372001324	ATP binding site [chemical binding]; other site
383372001325	Q-loop/lid; other site
383372001326	ABC transporter signature motif; other site
383372001327	Walker B; other site
383372001328	D-loop; other site
383372001329	H-loop/switch region; other site
383372001330	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
383372001331	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
383372001332	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372001333	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372001334	active site
383372001335	phosphorylation site [posttranslational modification]
383372001336	intermolecular recognition site; other site
383372001337	dimerization interface [polypeptide binding]; other site
383372001338	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372001339	DNA binding site [nucleotide binding]
383372001340	Response regulator receiver domain; Region: Response_reg; pfam00072
383372001341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372001342	active site
383372001343	phosphorylation site [posttranslational modification]
383372001344	intermolecular recognition site; other site
383372001345	dimerization interface [polypeptide binding]; other site
383372001346	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
383372001347	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
383372001348	FG-GAP repeat; Region: FG-GAP_2; pfam14312
383372001349	FG-GAP repeat; Region: FG-GAP_2; pfam14312
383372001350	FG-GAP repeat; Region: FG-GAP_2; pfam14312
383372001351	FG-GAP repeat; Region: FG-GAP_2; pfam14312
383372001352	FG-GAP repeat; Region: FG-GAP_2; pfam14312
383372001353	FG-GAP repeat; Region: FG-GAP_2; pfam14312
383372001354	AAA ATPase domain; Region: AAA_16; pfam13191
383372001355	AAA domain; Region: AAA_22; pfam13401
383372001356	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
383372001357	putative ADP-ribose binding site [chemical binding]; other site
383372001358	putative active site [active]
383372001359	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
383372001360	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
383372001361	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
383372001362	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
383372001363	trimer interface [polypeptide binding]; other site
383372001364	active site
383372001365	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
383372001366	active site
383372001367	Ap6A binding site [chemical binding]; other site
383372001368	nudix motif; other site
383372001369	metal binding site [ion binding]; metal-binding site
383372001370	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
383372001371	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
383372001372	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
383372001373	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
383372001374	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372001375	putative active site [active]
383372001376	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
383372001377	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
383372001378	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
383372001379	catalytic triad [active]
383372001380	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
383372001381	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
383372001382	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
383372001383	Protein of unknown function, DUF608; Region: DUF608; pfam04685
383372001384	Integral membrane protein TerC family; Region: TerC; cl10468
383372001385	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
383372001386	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
383372001387	GDP-binding site [chemical binding]; other site
383372001388	ACT binding site; other site
383372001389	IMP binding site; other site
383372001390	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
383372001391	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
383372001392	P-loop; other site
383372001393	Magnesium ion binding site [ion binding]; other site
383372001394	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
383372001395	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
383372001396	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
383372001397	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
383372001398	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
383372001399	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372001400	active site
383372001401	motif I; other site
383372001402	motif II; other site
383372001403	Chain length determinant protein; Region: Wzz; cl15801
383372001404	Chain length determinant protein; Region: Wzz; cl15801
383372001405	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
383372001406	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
383372001407	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
383372001408	trimer interface [polypeptide binding]; other site
383372001409	active site
383372001410	substrate binding site [chemical binding]; other site
383372001411	CoA binding site [chemical binding]; other site
383372001412	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
383372001413	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
383372001414	Ligand binding site; other site
383372001415	Putative Catalytic site; other site
383372001416	DXD motif; other site
383372001417	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
383372001418	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
383372001419	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
383372001420	B12 binding site [chemical binding]; other site
383372001421	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372001422	FeS/SAM binding site; other site
383372001423	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
383372001424	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372001425	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372001426	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
383372001427	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
383372001428	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372001429	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
383372001430	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
383372001431	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
383372001432	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372001433	Probable Catalytic site; other site
383372001434	metal-binding site
383372001435	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
383372001436	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
383372001437	HlyD family secretion protein; Region: HlyD_3; pfam13437
383372001438	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372001439	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
383372001440	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
383372001441	Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579
383372001442	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
383372001443	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372001444	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372001445	Probable Catalytic site; other site
383372001446	metal-binding site
383372001447	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372001448	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
383372001449	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
383372001450	Asp-box motif; other site
383372001451	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
383372001452	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
383372001453	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
383372001454	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
383372001455	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
383372001456	active site
383372001457	Domain of unknown function DUF11; Region: DUF11; pfam01345
383372001458	Domain of unknown function DUF11; Region: DUF11; pfam01345
383372001459	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
383372001460	Restriction endonuclease; Region: Mrr_cat; pfam04471
383372001461	Bacterial SH3 domain; Region: SH3_3; pfam08239
383372001462	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
383372001463	excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14668
383372001464	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
383372001465	non-specific DNA interactions [nucleotide binding]; other site
383372001466	DNA binding site [nucleotide binding]
383372001467	sequence specific DNA binding site [nucleotide binding]; other site
383372001468	putative cAMP binding site [chemical binding]; other site
383372001469	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
383372001470	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
383372001471	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
383372001472	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
383372001473	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372001474	dimer interface [polypeptide binding]; other site
383372001475	conserved gate region; other site
383372001476	putative PBP binding loops; other site
383372001477	ABC-ATPase subunit interface; other site
383372001478	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
383372001479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372001480	dimer interface [polypeptide binding]; other site
383372001481	conserved gate region; other site
383372001482	putative PBP binding loops; other site
383372001483	ABC-ATPase subunit interface; other site
383372001484	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
383372001485	putative ligand binding site [chemical binding]; other site
383372001486	classical (c) SDRs; Region: SDR_c; cd05233
383372001487	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
383372001488	NAD(P) binding site [chemical binding]; other site
383372001489	active site
383372001490	CoA-binding domain; Region: CoA_binding_3; pfam13727
383372001491	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
383372001492	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
383372001493	NAD(P) binding site [chemical binding]; other site
383372001494	homodimer interface [polypeptide binding]; other site
383372001495	substrate binding site [chemical binding]; other site
383372001496	active site
383372001497	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
383372001498	putative active site [active]
383372001499	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
383372001500	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
383372001501	inhibitor-cofactor binding pocket; inhibition site
383372001502	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372001503	catalytic residue [active]
383372001504	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
383372001505	NAD synthetase; Reviewed; Region: nadE; PRK00876
383372001506	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
383372001507	Ligand Binding Site [chemical binding]; other site
383372001508	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
383372001509	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
383372001510	active site
383372001511	dimer interface [polypeptide binding]; other site
383372001512	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
383372001513	Ligand Binding Site [chemical binding]; other site
383372001514	Molecular Tunnel; other site
383372001515	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
383372001516	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
383372001517	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922
383372001518	acyl-activating enzyme (AAE) consensus motif; other site
383372001519	acyl-activating enzyme (AAE) consensus motif; other site
383372001520	putative AMP binding site [chemical binding]; other site
383372001521	putative active site [active]
383372001522	putative CoA binding site [chemical binding]; other site
383372001523	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
383372001524	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
383372001525	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
383372001526	Bacterial sugar transferase; Region: Bac_transf; pfam02397
383372001527	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
383372001528	putative ADP-binding pocket [chemical binding]; other site
383372001529	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372001530	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372001531	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
383372001532	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
383372001533	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
383372001534	HlyD family secretion protein; Region: HlyD_3; pfam13437
383372001535	Chain length determinant protein; Region: Wzz; cl15801
383372001536	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
383372001537	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
383372001538	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
383372001539	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
383372001540	active site
383372001541	metal binding site [ion binding]; metal-binding site
383372001542	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
383372001543	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
383372001544	Transglycosylase; Region: Transgly; pfam00912
383372001545	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
383372001546	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
383372001547	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
383372001548	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372001549	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372001550	active site
383372001551	ATP binding site [chemical binding]; other site
383372001552	substrate binding site [chemical binding]; other site
383372001553	activation loop (A-loop); other site
383372001554	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
383372001555	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
383372001556	DNA binding site [nucleotide binding]
383372001557	active site
383372001558	Transcriptional regulators [Transcription]; Region: PurR; COG1609
383372001559	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
383372001560	DNA binding site [nucleotide binding]
383372001561	domain linker motif; other site
383372001562	Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296
383372001563	putative dimerization interface [polypeptide binding]; other site
383372001564	putative ligand binding site [chemical binding]; other site
383372001565	PQQ-like domain; Region: PQQ_2; pfam13360
383372001566	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
383372001567	active site
383372001568	Trp docking motif [polypeptide binding]; other site
383372001569	PQQ-like domain; Region: PQQ_2; pfam13360
383372001570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372001571	dimer interface [polypeptide binding]; other site
383372001572	conserved gate region; other site
383372001573	putative PBP binding loops; other site
383372001574	ABC-ATPase subunit interface; other site
383372001575	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
383372001576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372001577	dimer interface [polypeptide binding]; other site
383372001578	conserved gate region; other site
383372001579	putative PBP binding loops; other site
383372001580	ABC-ATPase subunit interface; other site
383372001581	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
383372001582	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
383372001583	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
383372001584	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372001585	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372001586	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
383372001587	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
383372001588	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
383372001589	putative active site [active]
383372001590	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372001591	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372001592	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
383372001593	beta-galactosidase; Region: BGL; TIGR03356
383372001594	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
383372001595	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
383372001596	Potassium binding sites [ion binding]; other site
383372001597	Cesium cation binding sites [ion binding]; other site
383372001598	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
383372001599	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
383372001600	Putative esterase; Region: Esterase; pfam00756
383372001601	Predicted esterase [General function prediction only]; Region: COG0627
383372001602	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
383372001603	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372001604	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372001605	active site
383372001606	ATP binding site [chemical binding]; other site
383372001607	substrate binding site [chemical binding]; other site
383372001608	activation loop (A-loop); other site
383372001609	TPR repeat; Region: TPR_11; pfam13414
383372001610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372001611	TPR motif; other site
383372001612	binding surface
383372001613	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372001614	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372001615	binding surface
383372001616	TPR motif; other site
383372001617	TPR repeat; Region: TPR_11; pfam13414
383372001618	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372001619	TPR motif; other site
383372001620	binding surface
383372001621	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372001622	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372001623	binding surface
383372001624	TPR motif; other site
383372001625	TPR repeat; Region: TPR_11; pfam13414
383372001626	MFS_1 like family; Region: MFS_1_like; pfam12832
383372001627	sugar efflux transporter; Region: 2A0120; TIGR00899
383372001628	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372001629	putative substrate translocation pore; other site
383372001630	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
383372001631	active site
383372001632	catalytic triad [active]
383372001633	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
383372001634	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
383372001635	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372001636	Walker A/P-loop; other site
383372001637	ATP binding site [chemical binding]; other site
383372001638	Q-loop/lid; other site
383372001639	ABC transporter signature motif; other site
383372001640	Walker B; other site
383372001641	D-loop; other site
383372001642	H-loop/switch region; other site
383372001643	Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250
383372001644	Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060
383372001645	Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662
383372001646	Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060
383372001647	Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250
383372001648	Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060
383372001649	Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250
383372001650	Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250
383372001651	Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060
383372001652	Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250
383372001653	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372001654	TPR motif; other site
383372001655	Tetratricopeptide repeat; Region: TPR_16; pfam13432
383372001656	binding surface
383372001657	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372001658	TPR motif; other site
383372001659	binding surface
383372001660	TPR repeat; Region: TPR_11; pfam13414
383372001661	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
383372001662	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
383372001663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
383372001664	Protein of unknown function (DUF433); Region: DUF433; pfam04255
383372001665	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
383372001666	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
383372001667	acyl-activating enzyme (AAE) consensus motif; other site
383372001668	active site
383372001669	AMP binding site [chemical binding]; other site
383372001670	CoA binding site [chemical binding]; other site
383372001671	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
383372001672	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
383372001673	Walker A/P-loop; other site
383372001674	ATP binding site [chemical binding]; other site
383372001675	Q-loop/lid; other site
383372001676	ABC transporter signature motif; other site
383372001677	Walker B; other site
383372001678	D-loop; other site
383372001679	H-loop/switch region; other site
383372001680	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
383372001681	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
383372001682	putative ligand binding site [chemical binding]; other site
383372001683	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
383372001684	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
383372001685	TM-ABC transporter signature motif; other site
383372001686	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
383372001687	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
383372001688	TM-ABC transporter signature motif; other site
383372001689	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
383372001690	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
383372001691	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
383372001692	acyl-activating enzyme (AAE) consensus motif; other site
383372001693	putative active site [active]
383372001694	putative AMP binding site [chemical binding]; other site
383372001695	putative CoA binding site [chemical binding]; other site
383372001696	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
383372001697	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
383372001698	Walker A/P-loop; other site
383372001699	ATP binding site [chemical binding]; other site
383372001700	Q-loop/lid; other site
383372001701	ABC transporter signature motif; other site
383372001702	Walker B; other site
383372001703	D-loop; other site
383372001704	H-loop/switch region; other site
383372001705	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
383372001706	Metallopeptidase family M24; Region: Peptidase_M24; pfam00557
383372001707	active site
383372001708	endonuclease IV; Provisional; Region: PRK01060
383372001709	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
383372001710	AP (apurinic/apyrimidinic) site pocket; other site
383372001711	DNA interaction; other site
383372001712	Metal-binding active site; metal-binding site
383372001713	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
383372001714	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372001715	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
383372001716	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
383372001717	ATP-grasp domain; Region: ATP-grasp_4; cl17255
383372001718	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
383372001719	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
383372001720	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372001721	S-adenosylmethionine binding site [chemical binding]; other site
383372001722	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372001723	putative active site [active]
383372001724	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
383372001725	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
383372001726	dimer interface [polypeptide binding]; other site
383372001727	active site
383372001728	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
383372001729	substrate binding site [chemical binding]; other site
383372001730	catalytic residue [active]
383372001731	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
383372001732	active site
383372001733	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
383372001734	active site
383372001735	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
383372001736	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
383372001737	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
383372001738	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
383372001739	RNA binding surface [nucleotide binding]; other site
383372001740	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
383372001741	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
383372001742	CoA-transferase family III; Region: CoA_transf_3; pfam02515
383372001743	malonyl-CoA synthase; Validated; Region: PRK07514
383372001744	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
383372001745	acyl-activating enzyme (AAE) consensus motif; other site
383372001746	active site
383372001747	AMP binding site [chemical binding]; other site
383372001748	CoA binding site [chemical binding]; other site
383372001749	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
383372001750	FAD binding domain; Region: FAD_binding_4; pfam01565
383372001751	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
383372001752	Cysteine-rich domain; Region: CCG; pfam02754
383372001753	Amino acid permease; Region: AA_permease_2; pfam13520
383372001754	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
383372001755	SPFH domain / Band 7 family; Region: Band_7; pfam01145
383372001756	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
383372001757	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
383372001758	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
383372001759	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
383372001760	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
383372001761	AAA ATPase domain; Region: AAA_16; pfam13191
383372001762	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372001763	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372001764	DNA binding site [nucleotide binding]
383372001765	Domain of unknown function (DUF897); Region: DUF897; pfam05982
383372001766	Nitrogen regulatory protein P-II; Region: P-II; cl00412
383372001767	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
383372001768	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
383372001769	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
383372001770	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
383372001771	HEPN domain; Region: HEPN; pfam05168
383372001772	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372001773	active site
383372001774	NTP binding site [chemical binding]; other site
383372001775	metal binding triad [ion binding]; metal-binding site
383372001776	antibiotic binding site [chemical binding]; other site
383372001777	HEPN domain; Region: HEPN; pfam05168
383372001778	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372001779	active site
383372001780	NTP binding site [chemical binding]; other site
383372001781	metal binding triad [ion binding]; metal-binding site
383372001782	antibiotic binding site [chemical binding]; other site
383372001783	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372001784	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372001785	active site
383372001786	ATP binding site [chemical binding]; other site
383372001787	substrate binding site [chemical binding]; other site
383372001788	activation loop (A-loop); other site
383372001789	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
383372001790	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
383372001791	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
383372001792	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
383372001793	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
383372001794	TPR repeat; Region: TPR_11; pfam13414
383372001795	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372001796	binding surface
383372001797	TPR motif; other site
383372001798	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372001799	TPR repeat; Region: TPR_11; pfam13414
383372001800	binding surface
383372001801	TPR motif; other site
383372001802	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
383372001803	Citrate synthase; Region: Citrate_synt; pfam00285
383372001804	oxalacetate binding site [chemical binding]; other site
383372001805	citrylCoA binding site [chemical binding]; other site
383372001806	coenzyme A binding site [chemical binding]; other site
383372001807	catalytic triad [active]
383372001808	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
383372001809	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
383372001810	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
383372001811	FAD binding site [chemical binding]; other site
383372001812	homotetramer interface [polypeptide binding]; other site
383372001813	substrate binding pocket [chemical binding]; other site
383372001814	catalytic base [active]
383372001815	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
383372001816	PhoU domain; Region: PhoU; pfam01895
383372001817	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
383372001818	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
383372001819	Walker A/P-loop; other site
383372001820	ATP binding site [chemical binding]; other site
383372001821	Q-loop/lid; other site
383372001822	ABC transporter signature motif; other site
383372001823	Walker B; other site
383372001824	D-loop; other site
383372001825	H-loop/switch region; other site
383372001826	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
383372001827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372001828	dimer interface [polypeptide binding]; other site
383372001829	conserved gate region; other site
383372001830	putative PBP binding loops; other site
383372001831	ABC-ATPase subunit interface; other site
383372001832	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
383372001833	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372001834	dimer interface [polypeptide binding]; other site
383372001835	conserved gate region; other site
383372001836	putative PBP binding loops; other site
383372001837	ABC-ATPase subunit interface; other site
383372001838	PBP superfamily domain; Region: PBP_like_2; cl17296
383372001839	PBP superfamily domain; Region: PBP_like_2; cl17296
383372001840	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372001841	dimerization interface [polypeptide binding]; other site
383372001842	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372001843	PAS domain; Region: PAS; smart00091
383372001844	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
383372001845	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372001846	dimer interface [polypeptide binding]; other site
383372001847	phosphorylation site [posttranslational modification]
383372001848	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372001849	ATP binding site [chemical binding]; other site
383372001850	G-X-G motif; other site
383372001851	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372001852	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372001853	active site
383372001854	phosphorylation site [posttranslational modification]
383372001855	intermolecular recognition site; other site
383372001856	dimerization interface [polypeptide binding]; other site
383372001857	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372001858	DNA binding site [nucleotide binding]
383372001859	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
383372001860	active site
383372001861	catalytic residues [active]
383372001862	metal binding site [ion binding]; metal-binding site
383372001863	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
383372001864	active site
383372001865	PQQ-like domain; Region: PQQ_2; pfam13360
383372001866	Trp docking motif [polypeptide binding]; other site
383372001867	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
383372001868	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
383372001869	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
383372001870	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
383372001871	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
383372001872	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
383372001873	generic binding surface II; other site
383372001874	ssDNA binding site; other site
383372001875	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
383372001876	ATP binding site [chemical binding]; other site
383372001877	putative Mg++ binding site [ion binding]; other site
383372001878	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
383372001879	nucleotide binding region [chemical binding]; other site
383372001880	ATP-binding site [chemical binding]; other site
383372001881	EDD domain protein, DegV family; Region: DegV; TIGR00762
383372001882	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
383372001883	EDD domain protein, DegV family; Region: DegV; TIGR00762
383372001884	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
383372001885	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
383372001886	DAK2 domain; Region: Dak2; pfam02734
383372001887	Asp23 family; Region: Asp23; pfam03780
383372001888	Ribosomal L28 family; Region: Ribosomal_L28; pfam00830
383372001889	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372001890	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
383372001891	active site
383372001892	motif I; other site
383372001893	motif II; other site
383372001894	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372001895	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
383372001896	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
383372001897	ligand binding site [chemical binding]; other site
383372001898	NAD binding site [chemical binding]; other site
383372001899	dimerization interface [polypeptide binding]; other site
383372001900	catalytic site [active]
383372001901	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
383372001902	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
383372001903	Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147
383372001904	NAD(P) binding site [chemical binding]; other site
383372001905	catalytic residues [active]
383372001906	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
383372001907	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372001908	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372001909	putative active site [active]
383372001910	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
383372001911	active site
383372001912	Int/Topo IB signature motif; other site
383372001913	DNA binding site [nucleotide binding]
383372001914	PemK-like protein; Region: PemK; pfam02452
383372001915	Mrr N-terminal domain; Region: Mrr_N; pfam14338
383372001916	EamA-like transporter family; Region: EamA; pfam00892
383372001917	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372001918	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
383372001919	substrate binding pocket [chemical binding]; other site
383372001920	substrate-Mg2+ binding site; other site
383372001921	aspartate-rich region 1; other site
383372001922	aspartate-rich region 2; other site
383372001923	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372001924	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372001925	S-adenosylmethionine binding site [chemical binding]; other site
383372001926	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
383372001927	Beta-lactamase; Region: Beta-lactamase; pfam00144
383372001928	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
383372001929	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
383372001930	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
383372001931	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
383372001932	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
383372001933	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
383372001934	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
383372001935	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
383372001936	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
383372001937	ABC1 family; Region: ABC1; cl17513
383372001938	cobyric acid synthase; Provisional; Region: PRK00784
383372001939	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
383372001940	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
383372001941	catalytic triad [active]
383372001942	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
383372001943	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
383372001944	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372001945	homodimer interface [polypeptide binding]; other site
383372001946	catalytic residue [active]
383372001947	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
383372001948	homotrimer interface [polypeptide binding]; other site
383372001949	Walker A motif; other site
383372001950	GTP binding site [chemical binding]; other site
383372001951	Walker B motif; other site
383372001952	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
383372001953	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
383372001954	catalytic triad [active]
383372001955	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
383372001956	active site
383372001957	SAM binding site [chemical binding]; other site
383372001958	homodimer interface [polypeptide binding]; other site
383372001959	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
383372001960	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
383372001961	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
383372001962	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
383372001963	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
383372001964	active site
383372001965	SAM binding site [chemical binding]; other site
383372001966	homodimer interface [polypeptide binding]; other site
383372001967	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
383372001968	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
383372001969	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
383372001970	active site
383372001971	SAM binding site [chemical binding]; other site
383372001972	homodimer interface [polypeptide binding]; other site
383372001973	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
383372001974	active site
383372001975	SAM binding site [chemical binding]; other site
383372001976	homodimer interface [polypeptide binding]; other site
383372001977	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
383372001978	active site
383372001979	putative homodimer interface [polypeptide binding]; other site
383372001980	SAM binding site [chemical binding]; other site
383372001981	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
383372001982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372001983	S-adenosylmethionine binding site [chemical binding]; other site
383372001984	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
383372001985	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
383372001986	Precorrin-8X methylmutase; Region: CbiC; pfam02570
383372001987	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
383372001988	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
383372001989	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
383372001990	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
383372001991	putative active site [active]
383372001992	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
383372001993	putative active site [active]
383372001994	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
383372001995	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
383372001996	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
383372001997	Walker A/P-loop; other site
383372001998	ATP binding site [chemical binding]; other site
383372001999	Q-loop/lid; other site
383372002000	ABC transporter signature motif; other site
383372002001	Walker B; other site
383372002002	D-loop; other site
383372002003	H-loop/switch region; other site
383372002004	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
383372002005	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
383372002006	putative dimer interface [polypeptide binding]; other site
383372002007	active site pocket [active]
383372002008	putative cataytic base [active]
383372002009	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
383372002010	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
383372002011	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
383372002012	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
383372002013	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
383372002014	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
383372002015	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
383372002016	Walker A motif; other site
383372002017	homodimer interface [polypeptide binding]; other site
383372002018	ATP binding site [chemical binding]; other site
383372002019	hydroxycobalamin binding site [chemical binding]; other site
383372002020	Walker B motif; other site
383372002021	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
383372002022	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
383372002023	Walker A/P-loop; other site
383372002024	ATP binding site [chemical binding]; other site
383372002025	Q-loop/lid; other site
383372002026	ABC transporter signature motif; other site
383372002027	Walker B; other site
383372002028	D-loop; other site
383372002029	H-loop/switch region; other site
383372002030	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
383372002031	putative carbohydrate binding site [chemical binding]; other site
383372002032	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372002033	putative active site [active]
383372002034	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
383372002035	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
383372002036	active site
383372002037	metal binding site [ion binding]; metal-binding site
383372002038	MoxR-like ATPases [General function prediction only]; Region: COG0714
383372002039	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372002040	Walker A motif; other site
383372002041	ATP binding site [chemical binding]; other site
383372002042	Walker B motif; other site
383372002043	arginine finger; other site
383372002044	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372002045	metal ion-dependent adhesion site (MIDAS); other site
383372002046	phosphoglyceromutase; Provisional; Region: PRK05434
383372002047	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
383372002048	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
383372002049	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
383372002050	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
383372002051	nucleotide binding region [chemical binding]; other site
383372002052	SEC-C motif; Region: SEC-C; pfam02810
383372002053	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
383372002054	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
383372002055	Ligand binding site; other site
383372002056	metal-binding site
383372002057	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
383372002058	putative MPT binding site; other site
383372002059	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
383372002060	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
383372002061	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
383372002062	Domain of unknown function DUF77; Region: DUF77; pfam01910
383372002063	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
383372002064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372002065	dimer interface [polypeptide binding]; other site
383372002066	conserved gate region; other site
383372002067	putative PBP binding loops; other site
383372002068	ABC-ATPase subunit interface; other site
383372002069	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
383372002070	NMT1/THI5 like; Region: NMT1; pfam09084
383372002071	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
383372002072	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
383372002073	Walker A/P-loop; other site
383372002074	ATP binding site [chemical binding]; other site
383372002075	Q-loop/lid; other site
383372002076	ABC transporter signature motif; other site
383372002077	Walker B; other site
383372002078	D-loop; other site
383372002079	H-loop/switch region; other site
383372002080	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
383372002081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372002082	active site
383372002083	phosphorylation site [posttranslational modification]
383372002084	dimerization interface [polypeptide binding]; other site
383372002085	PAS domain S-box; Region: sensory_box; TIGR00229
383372002086	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372002087	putative active site [active]
383372002088	heme pocket [chemical binding]; other site
383372002089	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372002090	GAF domain; Region: GAF_3; pfam13492
383372002091	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372002092	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372002093	Response regulator receiver domain; Region: Response_reg; pfam00072
383372002094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372002095	active site
383372002096	phosphorylation site [posttranslational modification]
383372002097	dimerization interface [polypeptide binding]; other site
383372002098	circadian clock protein KaiC; Reviewed; Region: PRK09302
383372002099	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
383372002100	Walker A motif; other site
383372002101	Walker A motif; other site
383372002102	ATP binding site [chemical binding]; other site
383372002103	Walker B motif; other site
383372002104	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
383372002105	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
383372002106	Walker A motif; other site
383372002107	Walker A motif; other site
383372002108	ATP binding site [chemical binding]; other site
383372002109	Walker B motif; other site
383372002110	Pleckstrin homology-like domain; Region: PH-like; cl17171
383372002111	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
383372002112	IHF dimer interface [polypeptide binding]; other site
383372002113	IHF - DNA interface [nucleotide binding]; other site
383372002114	Response regulator receiver domain; Region: Response_reg; pfam00072
383372002115	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372002116	active site
383372002117	phosphorylation site [posttranslational modification]
383372002118	intermolecular recognition site; other site
383372002119	dimerization interface [polypeptide binding]; other site
383372002120	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
383372002121	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372002122	ATP binding site [chemical binding]; other site
383372002123	Mg2+ binding site [ion binding]; other site
383372002124	G-X-G motif; other site
383372002125	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372002126	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
383372002127	nudix motif; other site
383372002128	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
383372002129	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
383372002130	nucleotide binding site [chemical binding]; other site
383372002131	Lamin Tail Domain; Region: LTD; pfam00932
383372002132	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
383372002133	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
383372002134	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
383372002135	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
383372002136	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
383372002137	dimer interface [polypeptide binding]; other site
383372002138	putative functional site; other site
383372002139	putative MPT binding site; other site
383372002140	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372002141	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
383372002142	FeS/SAM binding site; other site
383372002143	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
383372002144	AAA ATPase domain; Region: AAA_16; pfam13191
383372002145	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372002146	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
383372002147	DNA binding site [nucleotide binding]
383372002148	HerA helicase [Replication, recombination, and repair]; Region: COG0433
383372002149	Domain of unknown function DUF87; Region: DUF87; pfam01935
383372002150	NurA domain; Region: NurA; cl09134
383372002151	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
383372002152	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
383372002153	Walker A/P-loop; other site
383372002154	ATP binding site [chemical binding]; other site
383372002155	Q-loop/lid; other site
383372002156	ABC transporter signature motif; other site
383372002157	Walker B; other site
383372002158	D-loop; other site
383372002159	H-loop/switch region; other site
383372002160	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
383372002161	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
383372002162	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
383372002163	Peptidase M16C associated; Region: M16C_assoc; pfam08367
383372002164	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
383372002165	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
383372002166	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372002167	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372002168	DNA binding residues [nucleotide binding]
383372002169	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
383372002170	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
383372002171	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
383372002172	acyl-activating enzyme (AAE) consensus motif; other site
383372002173	acyl-activating enzyme (AAE) consensus motif; other site
383372002174	putative AMP binding site [chemical binding]; other site
383372002175	putative active site [active]
383372002176	putative CoA binding site [chemical binding]; other site
383372002177	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
383372002178	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
383372002179	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
383372002180	AAA ATPase domain; Region: AAA_16; pfam13191
383372002181	NACHT domain; Region: NACHT; pfam05729
383372002182	Bacterial transcriptional activator domain; Region: BTAD; smart01043
383372002183	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
383372002184	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
383372002185	NAD(P) binding site [chemical binding]; other site
383372002186	homotetramer interface [polypeptide binding]; other site
383372002187	homodimer interface [polypeptide binding]; other site
383372002188	active site
383372002189	beta-ketothiolase; Provisional; Region: PRK09051
383372002190	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
383372002191	dimer interface [polypeptide binding]; other site
383372002192	active site
383372002193	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
383372002194	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372002195	Coenzyme A binding pocket [chemical binding]; other site
383372002196	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
383372002197	HEPN domain; Region: HEPN; pfam05168
383372002198	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372002199	active site
383372002200	NTP binding site [chemical binding]; other site
383372002201	metal binding triad [ion binding]; metal-binding site
383372002202	antibiotic binding site [chemical binding]; other site
383372002203	Uncharacterized ACR (DUF711); Region: DUF711; pfam05167
383372002204	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
383372002205	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
383372002206	putative ligand binding site [chemical binding]; other site
383372002207	putative NAD binding site [chemical binding]; other site
383372002208	catalytic site [active]
383372002209	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
383372002210	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
383372002211	active site
383372002212	dimer interface [polypeptide binding]; other site
383372002213	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
383372002214	dimer interface [polypeptide binding]; other site
383372002215	active site
383372002216	Protein of unknown function (DUF433); Region: DUF433; pfam04255
383372002217	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
383372002218	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
383372002219	Glycoprotease family; Region: Peptidase_M22; pfam00814
383372002220	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
383372002221	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
383372002222	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
383372002223	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
383372002224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372002225	Walker A motif; other site
383372002226	ATP binding site [chemical binding]; other site
383372002227	Walker B motif; other site
383372002228	arginine finger; other site
383372002229	Peptidase family M41; Region: Peptidase_M41; pfam01434
383372002230	hypothetical protein; Validated; Region: PRK00110
383372002231	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
383372002232	active site
383372002233	putative DNA-binding cleft [nucleotide binding]; other site
383372002234	dimer interface [polypeptide binding]; other site
383372002235	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372002236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372002237	S-adenosylmethionine binding site [chemical binding]; other site
383372002238	Domain of unknown function DUF77; Region: DUF77; cl00307
383372002239	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372002240	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
383372002241	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
383372002242	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372002243	Coenzyme A binding pocket [chemical binding]; other site
383372002244	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
383372002245	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
383372002246	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
383372002247	NAD(P) binding site [chemical binding]; other site
383372002248	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
383372002249	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
383372002250	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
383372002251	Walker A/P-loop; other site
383372002252	ATP binding site [chemical binding]; other site
383372002253	Q-loop/lid; other site
383372002254	ABC transporter signature motif; other site
383372002255	Walker B; other site
383372002256	D-loop; other site
383372002257	H-loop/switch region; other site
383372002258	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
383372002259	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
383372002260	Predicted membrane protein [Function unknown]; Region: COG1470
383372002261	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
383372002262	Response regulator receiver domain; Region: Response_reg; pfam00072
383372002263	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372002264	active site
383372002265	phosphorylation site [posttranslational modification]
383372002266	intermolecular recognition site; other site
383372002267	dimerization interface [polypeptide binding]; other site
383372002268	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
383372002269	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
383372002270	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
383372002271	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372002272	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372002273	DNA binding residues [nucleotide binding]
383372002274	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
383372002275	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372002276	ATP binding site [chemical binding]; other site
383372002277	Mg2+ binding site [ion binding]; other site
383372002278	G-X-G motif; other site
383372002279	O-Antigen ligase; Region: Wzy_C; cl04850
383372002280	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
383372002281	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
383372002282	tetramer interface [polypeptide binding]; other site
383372002283	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372002284	catalytic residue [active]
383372002285	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
383372002286	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
383372002287	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
383372002288	homodimer interface [polypeptide binding]; other site
383372002289	NADP binding site [chemical binding]; other site
383372002290	substrate binding site [chemical binding]; other site
383372002291	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
383372002292	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
383372002293	Substrate binding site; other site
383372002294	Mg++ binding site; other site
383372002295	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
383372002296	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
383372002297	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
383372002298	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
383372002299	active site
383372002300	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
383372002301	Domain of unknown function DUF21; Region: DUF21; pfam01595
383372002302	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
383372002303	Transporter associated domain; Region: CorC_HlyC; smart01091
383372002304	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
383372002305	active site
383372002306	catalytic motif [active]
383372002307	Zn binding site [ion binding]; other site
383372002308	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
383372002309	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
383372002310	active site
383372002311	Substrate binding site; other site
383372002312	Mg++ binding site; other site
383372002313	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
383372002314	putative trimer interface [polypeptide binding]; other site
383372002315	putative CoA binding site [chemical binding]; other site
383372002316	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
383372002317	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
383372002318	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
383372002319	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
383372002320	EamA-like transporter family; Region: EamA; pfam00892
383372002321	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372002322	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372002323	GAF domain; Region: GAF_2; pfam13185
383372002324	GAF domain; Region: GAF_3; pfam13492
383372002325	GAF domain; Region: GAF_2; pfam13185
383372002326	GAF domain; Region: GAF_3; pfam13492
383372002327	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
383372002328	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
383372002329	metal binding site [ion binding]; metal-binding site
383372002330	active site
383372002331	I-site; other site
383372002332	multidrug resistance protein MdtH; Provisional; Region: PRK11646
383372002333	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372002334	putative substrate translocation pore; other site
383372002335	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
383372002336	hypothetical protein; Provisional; Region: PRK06815
383372002337	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
383372002338	tetramer interface [polypeptide binding]; other site
383372002339	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372002340	catalytic residue [active]
383372002341	DNA polymerase III subunit beta; Validated; Region: PRK05643
383372002342	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
383372002343	putative DNA binding surface [nucleotide binding]; other site
383372002344	dimer interface [polypeptide binding]; other site
383372002345	beta-clamp/clamp loader binding surface; other site
383372002346	beta-clamp/translesion DNA polymerase binding surface; other site
383372002347	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
383372002348	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372002349	TPR repeat; Region: TPR_11; pfam13414
383372002350	binding surface
383372002351	TPR motif; other site
383372002352	Predicted membrane protein [Function unknown]; Region: COG3463
383372002353	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
383372002354	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
383372002355	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
383372002356	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372002357	Methyltransferase domain; Region: Methyltransf_11; pfam08241
383372002358	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
383372002359	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
383372002360	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372002361	Probable Catalytic site; other site
383372002362	metal-binding site
383372002363	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372002364	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372002365	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
383372002366	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
383372002367	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
383372002368	Ligand binding site; other site
383372002369	Putative Catalytic site; other site
383372002370	DXD motif; other site
383372002371	Protein of unknown function DUF86; Region: DUF86; pfam01934
383372002372	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372002373	active site
383372002374	NTP binding site [chemical binding]; other site
383372002375	metal binding triad [ion binding]; metal-binding site
383372002376	antibiotic binding site [chemical binding]; other site
383372002377	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
383372002378	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
383372002379	active site
383372002380	dimer interface [polypeptide binding]; other site
383372002381	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
383372002382	Ligand Binding Site [chemical binding]; other site
383372002383	Molecular Tunnel; other site
383372002384	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931
383372002385	putative active site [active]
383372002386	putative catalytic site [active]
383372002387	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
383372002388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372002389	S-adenosylmethionine binding site [chemical binding]; other site
383372002390	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372002391	Protein of unknown function (DUF2872); Region: DUF2872; cl11924
383372002392	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
383372002393	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
383372002394	pseudaminic acid synthase; Region: PseI; TIGR03586
383372002395	NeuB family; Region: NeuB; pfam03102
383372002396	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
383372002397	NeuB binding interface [polypeptide binding]; other site
383372002398	putative substrate binding site [chemical binding]; other site
383372002399	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
383372002400	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372002401	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
383372002402	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
383372002403	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
383372002404	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
383372002405	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
383372002406	inhibitor-cofactor binding pocket; inhibition site
383372002407	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372002408	catalytic residue [active]
383372002409	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
383372002410	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
383372002411	NAD(P) binding site [chemical binding]; other site
383372002412	homodimer interface [polypeptide binding]; other site
383372002413	substrate binding site [chemical binding]; other site
383372002414	active site
383372002415	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372002416	putative active site [active]
383372002417	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
383372002418	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
383372002419	inhibitor-cofactor binding pocket; inhibition site
383372002420	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372002421	catalytic residue [active]
383372002422	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
383372002423	four helix bundle protein; Region: TIGR02436
383372002424	putative trimer interface [polypeptide binding]; other site
383372002425	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
383372002426	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
383372002427	putative CoA binding site [chemical binding]; other site
383372002428	putative trimer interface [polypeptide binding]; other site
383372002429	putative active site [active]
383372002430	putative substrate binding site [chemical binding]; other site
383372002431	putative CoA binding site [chemical binding]; other site
383372002432	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
383372002433	active site
383372002434	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
383372002435	homodimer interface [polypeptide binding]; other site
383372002436	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372002437	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372002438	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372002439	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
383372002440	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372002441	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
383372002442	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372002443	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372002444	Probable Catalytic site; other site
383372002445	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
383372002446	metal-binding site
383372002447	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372002448	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372002449	Probable Catalytic site; other site
383372002450	metal-binding site
383372002451	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
383372002452	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
383372002453	active site
383372002454	dimer interface [polypeptide binding]; other site
383372002455	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
383372002456	Ligand Binding Site [chemical binding]; other site
383372002457	Molecular Tunnel; other site
383372002458	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372002459	putative active site [active]
383372002460	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372002461	putative active site [active]
383372002462	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372002463	putative active site [active]
383372002464	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372002465	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
383372002466	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
383372002467	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
383372002468	Ligand binding site; other site
383372002469	Putative Catalytic site; other site
383372002470	DXD motif; other site
383372002471	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372002472	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372002473	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
383372002474	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
383372002475	Response regulator receiver domain; Region: Response_reg; pfam00072
383372002476	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372002477	active site
383372002478	phosphorylation site [posttranslational modification]
383372002479	intermolecular recognition site; other site
383372002480	dimerization interface [polypeptide binding]; other site
383372002481	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
383372002482	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
383372002483	metal binding site [ion binding]; metal-binding site
383372002484	active site
383372002485	I-site; other site
383372002486	GAF domain; Region: GAF; pfam01590
383372002487	GAF domain; Region: GAF; pfam01590
383372002488	GAF domain; Region: GAF_2; pfam13185
383372002489	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372002490	GAF domain; Region: GAF_3; pfam13492
383372002491	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372002492	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372002493	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372002494	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372002495	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372002496	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372002497	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372002498	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372002499	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372002500	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372002501	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372002502	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372002503	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372002504	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372002505	putative active site [active]
383372002506	heme pocket [chemical binding]; other site
383372002507	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372002508	dimer interface [polypeptide binding]; other site
383372002509	phosphorylation site [posttranslational modification]
383372002510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372002511	ATP binding site [chemical binding]; other site
383372002512	Mg2+ binding site [ion binding]; other site
383372002513	G-X-G motif; other site
383372002514	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
383372002515	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
383372002516	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
383372002517	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
383372002518	putative NAD(P) binding site [chemical binding]; other site
383372002519	catalytic Zn binding site [ion binding]; other site
383372002520	Methyltransferase domain; Region: Methyltransf_31; pfam13847
383372002521	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372002522	S-adenosylmethionine binding site [chemical binding]; other site
383372002523	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
383372002524	4Fe-4S binding domain; Region: Fer4; cl02805
383372002525	Cysteine-rich domain; Region: CCG; pfam02754
383372002526	Cysteine-rich domain; Region: CCG; pfam02754
383372002527	Cysteine-rich domain; Region: CCG; pfam02754
383372002528	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
383372002529	Cysteine-rich domain; Region: CCG; pfam02754
383372002530	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
383372002531	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
383372002532	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
383372002533	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
383372002534	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
383372002535	active site
383372002536	catalytic site [active]
383372002537	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
383372002538	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372002539	putative active site [active]
383372002540	YwiC-like protein; Region: YwiC; pfam14256
383372002541	Cupin domain; Region: Cupin_2; cl17218
383372002542	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372002543	S-adenosylmethionine binding site [chemical binding]; other site
383372002544	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
383372002545	Iron permease FTR1 family; Region: FTR1; cl00475
383372002546	Imelysin; Region: Peptidase_M75; cl09159
383372002547	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
383372002548	kynureninase; Region: kynureninase; TIGR01814
383372002549	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
383372002550	catalytic residue [active]
383372002551	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
383372002552	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
383372002553	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
383372002554	catalytic residue [active]
383372002555	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
383372002556	Cysteine-rich domain; Region: CCG; pfam02754
383372002557	Cysteine-rich domain; Region: CCG; pfam02754
383372002558	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
383372002559	active site
383372002560	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
383372002561	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
383372002562	Zn2+ binding site [ion binding]; other site
383372002563	Mg2+ binding site [ion binding]; other site
383372002564	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
383372002565	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
383372002566	putative active site [active]
383372002567	CbiX; Region: CbiX; pfam01903
383372002568	active site
383372002569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372002570	Major Facilitator Superfamily; Region: MFS_1; pfam07690
383372002571	putative substrate translocation pore; other site
383372002572	GAF domain; Region: GAF_3; pfam13492
383372002573	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372002574	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372002575	dimer interface [polypeptide binding]; other site
383372002576	phosphorylation site [posttranslational modification]
383372002577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372002578	ATP binding site [chemical binding]; other site
383372002579	Mg2+ binding site [ion binding]; other site
383372002580	G-X-G motif; other site
383372002581	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372002582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372002583	active site
383372002584	phosphorylation site [posttranslational modification]
383372002585	intermolecular recognition site; other site
383372002586	dimerization interface [polypeptide binding]; other site
383372002587	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372002588	DNA binding site [nucleotide binding]
383372002589	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
383372002590	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
383372002591	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
383372002592	catalytic residues [active]
383372002593	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
383372002594	Predicted transcriptional regulator [Transcription]; Region: COG1959
383372002595	Transcriptional regulator; Region: Rrf2; pfam02082
383372002596	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
383372002597	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
383372002598	active site
383372002599	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
383372002600	nucleotide binding site/active site [active]
383372002601	HIT family signature motif; other site
383372002602	catalytic residue [active]
383372002603	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
383372002604	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
383372002605	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
383372002606	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
383372002607	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
383372002608	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
383372002609	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
383372002610	catalytic loop [active]
383372002611	iron binding site [ion binding]; other site
383372002612	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
383372002613	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
383372002614	putative hydrophobic ligand binding site [chemical binding]; other site
383372002615	Response regulator receiver domain; Region: Response_reg; pfam00072
383372002616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372002617	active site
383372002618	phosphorylation site [posttranslational modification]
383372002619	intermolecular recognition site; other site
383372002620	dimerization interface [polypeptide binding]; other site
383372002621	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372002622	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372002623	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
383372002624	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
383372002625	Zn2+ binding site [ion binding]; other site
383372002626	Mg2+ binding site [ion binding]; other site
383372002627	Response regulator receiver domain; Region: Response_reg; pfam00072
383372002628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372002629	active site
383372002630	phosphorylation site [posttranslational modification]
383372002631	intermolecular recognition site; other site
383372002632	dimerization interface [polypeptide binding]; other site
383372002633	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
383372002634	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
383372002635	active site
383372002636	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
383372002637	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
383372002638	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
383372002639	active site
383372002640	nucleophile elbow; other site
383372002641	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
383372002642	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
383372002643	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372002644	motif II; other site
383372002645	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
383372002646	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372002647	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
383372002648	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
383372002649	Walker A/P-loop; other site
383372002650	ATP binding site [chemical binding]; other site
383372002651	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
383372002652	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
383372002653	ABC transporter signature motif; other site
383372002654	Walker B; other site
383372002655	D-loop; other site
383372002656	H-loop/switch region; other site
383372002657	phosphodiesterase; Provisional; Region: PRK12704
383372002658	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
383372002659	Zn2+ binding site [ion binding]; other site
383372002660	Mg2+ binding site [ion binding]; other site
383372002661	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
383372002662	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
383372002663	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
383372002664	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
383372002665	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
383372002666	Protein of unknown function DUF82; Region: DUF82; pfam01927
383372002667	Uncharacterized conserved protein [Function unknown]; Region: COG1656
383372002668	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
383372002669	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
383372002670	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
383372002671	catalytic residues [active]
383372002672	cytidylate kinase; Provisional; Region: cmk; PRK00023
383372002673	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
383372002674	CMP-binding site; other site
383372002675	The sites determining sugar specificity; other site
383372002676	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
383372002677	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
383372002678	TilS substrate C-terminal domain; Region: TilS_C; smart00977
383372002679	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
383372002680	active site
383372002681	tyrosine phenol-lyase; Provisional; Region: PRK13237
383372002682	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
383372002683	substrate binding site [chemical binding]; other site
383372002684	tetramer interface [polypeptide binding]; other site
383372002685	catalytic residue [active]
383372002686	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
383372002687	Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308
383372002688	putative ligand binding site [chemical binding]; other site
383372002689	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372002690	dimerization interface [polypeptide binding]; other site
383372002691	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372002692	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
383372002693	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
383372002694	Predicted amidohydrolase [General function prediction only]; Region: COG0388
383372002695	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
383372002696	active site
383372002697	catalytic triad [active]
383372002698	dimer interface [polypeptide binding]; other site
383372002699	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372002700	active site
383372002701	NTP binding site [chemical binding]; other site
383372002702	metal binding triad [ion binding]; metal-binding site
383372002703	hypothetical protein; Reviewed; Region: PRK09588
383372002704	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
383372002705	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
383372002706	DNA methylase; Region: N6_N4_Mtase; pfam01555
383372002707	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372002708	S-adenosylmethionine binding site [chemical binding]; other site
383372002709	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
383372002710	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
383372002711	nucleotide binding pocket [chemical binding]; other site
383372002712	K-X-D-G motif; other site
383372002713	catalytic site [active]
383372002714	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
383372002715	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
383372002716	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
383372002717	Dimer interface [polypeptide binding]; other site
383372002718	BRCT sequence motif; other site
383372002719	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
383372002720	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
383372002721	catalytic site [active]
383372002722	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366
383372002723	Transcriptional regulator [Transcription]; Region: LysR; COG0583
383372002724	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
383372002725	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
383372002726	putative dimerization interface [polypeptide binding]; other site
383372002727	aconitate hydratase; Validated; Region: PRK09277
383372002728	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
383372002729	substrate binding site [chemical binding]; other site
383372002730	ligand binding site [chemical binding]; other site
383372002731	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
383372002732	substrate binding site [chemical binding]; other site
383372002733	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372002734	active site
383372002735	NTP binding site [chemical binding]; other site
383372002736	metal binding triad [ion binding]; metal-binding site
383372002737	antibiotic binding site [chemical binding]; other site
383372002738	Protein of unknown function DUF86; Region: DUF86; cl01031
383372002739	DNA adenine methylase (dam); Region: dam; TIGR00571
383372002740	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
383372002741	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
383372002742	Dimer interface [polypeptide binding]; other site
383372002743	anticodon binding site; other site
383372002744	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
383372002745	homodimer interface [polypeptide binding]; other site
383372002746	motif 1; other site
383372002747	motif 2; other site
383372002748	active site
383372002749	motif 3; other site
383372002750	PAS fold; Region: PAS_4; pfam08448
383372002751	GAF domain; Region: GAF; pfam01590
383372002752	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372002753	GAF domain; Region: GAF_3; pfam13492
383372002754	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372002755	dimer interface [polypeptide binding]; other site
383372002756	phosphorylation site [posttranslational modification]
383372002757	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372002758	ATP binding site [chemical binding]; other site
383372002759	G-X-G motif; other site
383372002760	Response regulator receiver domain; Region: Response_reg; pfam00072
383372002761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372002762	active site
383372002763	phosphorylation site [posttranslational modification]
383372002764	intermolecular recognition site; other site
383372002765	dimerization interface [polypeptide binding]; other site
383372002766	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
383372002767	Beta-lactamase; Region: Beta-lactamase; pfam00144
383372002768	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
383372002769	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
383372002770	acyl-activating enzyme (AAE) consensus motif; other site
383372002771	putative AMP binding site [chemical binding]; other site
383372002772	putative active site [active]
383372002773	putative CoA binding site [chemical binding]; other site
383372002774	Family description; Region: ACT_7; pfam13840
383372002775	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
383372002776	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
383372002777	TAP-like protein; Region: Abhydrolase_4; pfam08386
383372002778	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
383372002779	PGAP1-like protein; Region: PGAP1; pfam07819
383372002780	TAP-like protein; Region: Abhydrolase_4; pfam08386
383372002781	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
383372002782	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
383372002783	Sulfate transporter family; Region: Sulfate_transp; pfam00916
383372002784	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
383372002785	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
383372002786	active site residue [active]
383372002787	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
383372002788	phage shock protein A; Region: phageshock_pspA; TIGR02977
383372002789	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
383372002790	putative homodimer interface [polypeptide binding]; other site
383372002791	putative active site pocket [active]
383372002792	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
383372002793	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
383372002794	Cysteine-rich domain; Region: CCG; pfam02754
383372002795	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
383372002796	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
383372002797	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
383372002798	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
383372002799	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
383372002800	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
383372002801	Walker A/P-loop; other site
383372002802	ATP binding site [chemical binding]; other site
383372002803	Q-loop/lid; other site
383372002804	ABC transporter signature motif; other site
383372002805	Walker B; other site
383372002806	D-loop; other site
383372002807	H-loop/switch region; other site
383372002808	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
383372002809	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
383372002810	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
383372002811	Walker A/P-loop; other site
383372002812	ATP binding site [chemical binding]; other site
383372002813	Q-loop/lid; other site
383372002814	ABC transporter signature motif; other site
383372002815	Walker B; other site
383372002816	D-loop; other site
383372002817	H-loop/switch region; other site
383372002818	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
383372002819	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
383372002820	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372002821	dimer interface [polypeptide binding]; other site
383372002822	conserved gate region; other site
383372002823	putative PBP binding loops; other site
383372002824	ABC-ATPase subunit interface; other site
383372002825	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
383372002826	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
383372002827	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
383372002828	substrate binding site [chemical binding]; other site
383372002829	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
383372002830	Transcriptional regulators [Transcription]; Region: PurR; COG1609
383372002831	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
383372002832	DNA binding site [nucleotide binding]
383372002833	Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296
383372002834	putative dimerization interface [polypeptide binding]; other site
383372002835	putative ligand binding site [chemical binding]; other site
383372002836	Uncharacterized conserved protein [Function unknown]; Region: COG3777
383372002837	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
383372002838	active site 2 [active]
383372002839	active site 1 [active]
383372002840	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
383372002841	CoA-transferase family III; Region: CoA_transf_3; pfam02515
383372002842	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
383372002843	CoA-transferase family III; Region: CoA_transf_3; pfam02515
383372002844	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
383372002845	CoA-transferase family III; Region: CoA_transf_3; pfam02515
383372002846	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
383372002847	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
383372002848	putative active site [active]
383372002849	putative catalytic site [active]
383372002850	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
383372002851	putative active site [active]
383372002852	putative catalytic site [active]
383372002853	enoyl-CoA hydratase; Validated; Region: PRK08139
383372002854	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
383372002855	substrate binding site [chemical binding]; other site
383372002856	oxyanion hole (OAH) forming residues; other site
383372002857	trimer interface [polypeptide binding]; other site
383372002858	dihydroorotase; Provisional; Region: PRK09237
383372002859	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
383372002860	active site
383372002861	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
383372002862	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
383372002863	NADP-binding site; other site
383372002864	homotetramer interface [polypeptide binding]; other site
383372002865	substrate binding site [chemical binding]; other site
383372002866	homodimer interface [polypeptide binding]; other site
383372002867	active site
383372002868	YceI-like domain; Region: YceI; pfam04264
383372002869	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
383372002870	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
383372002871	PA14 domain; Region: PA14; pfam07691
383372002872	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
383372002873	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
383372002874	Clp amino terminal domain; Region: Clp_N; pfam02861
383372002875	Clp amino terminal domain; Region: Clp_N; pfam02861
383372002876	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372002877	Walker A motif; other site
383372002878	ATP binding site [chemical binding]; other site
383372002879	Walker B motif; other site
383372002880	arginine finger; other site
383372002881	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
383372002882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372002883	Walker A motif; other site
383372002884	ATP binding site [chemical binding]; other site
383372002885	Walker B motif; other site
383372002886	arginine finger; other site
383372002887	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
383372002888	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
383372002889	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
383372002890	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
383372002891	fructose 1,6-bisphosphatase II; Reviewed; Region: glpX; PRK09479
383372002892	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
383372002893	active site
383372002894	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
383372002895	Aspartase; Region: Aspartase; cd01357
383372002896	active sites [active]
383372002897	tetramer interface [polypeptide binding]; other site
383372002898	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
383372002899	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372002900	CARDB; Region: CARDB; pfam07705
383372002901	Disulfide bond isomerase protein N-terminus; Region: DsbC_N; pfam10411
383372002902	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
383372002903	TrkA-N domain; Region: TrkA_N; pfam02254
383372002904	TrkA-N domain; Region: TrkA_N; pfam02254
383372002905	TrkA-C domain; Region: TrkA_C; pfam02080
383372002906	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
383372002907	ATP-NAD kinase; Region: NAD_kinase; pfam01513
383372002908	Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415
383372002909	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
383372002910	RNA binding site [nucleotide binding]; other site
383372002911	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
383372002912	RNA binding site [nucleotide binding]; other site
383372002913	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
383372002914	RNA binding site [nucleotide binding]; other site
383372002915	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
383372002916	RNA binding site [nucleotide binding]; other site
383372002917	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
383372002918	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
383372002919	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
383372002920	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
383372002921	active site
383372002922	catalytic site [active]
383372002923	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372002924	putative active site [active]
383372002925	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
383372002926	Beta-lactamase; Region: Beta-lactamase; pfam00144
383372002927	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372002928	Domain of unknown function (DUF368); Region: DUF368; pfam04018
383372002929	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
383372002930	DEAD-like helicases superfamily; Region: DEXDc; smart00487
383372002931	ATP binding site [chemical binding]; other site
383372002932	Mg++ binding site [ion binding]; other site
383372002933	motif III; other site
383372002934	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
383372002935	nucleotide binding region [chemical binding]; other site
383372002936	ATP-binding site [chemical binding]; other site
383372002937	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
383372002938	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
383372002939	active site
383372002940	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
383372002941	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
383372002942	ligand binding site; other site
383372002943	oligomer interface; other site
383372002944	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
383372002945	dimer interface [polypeptide binding]; other site
383372002946	N-terminal domain interface [polypeptide binding]; other site
383372002947	sulfate 1 binding site; other site
383372002948	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
383372002949	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
383372002950	ligand binding site; other site
383372002951	oligomer interface; other site
383372002952	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
383372002953	dimer interface [polypeptide binding]; other site
383372002954	N-terminal domain interface [polypeptide binding]; other site
383372002955	sulfate 1 binding site; other site
383372002956	Bacterial PH domain; Region: DUF304; pfam03703
383372002957	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
383372002958	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
383372002959	substrate binding site [chemical binding]; other site
383372002960	ATP binding site [chemical binding]; other site
383372002961	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
383372002962	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
383372002963	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
383372002964	putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641
383372002965	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
383372002966	carboxyltransferase (CT) interaction site; other site
383372002967	biotinylation site [posttranslational modification]; other site
383372002968	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
383372002969	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
383372002970	antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819
383372002971	toxin interface [polypeptide binding]; other site
383372002972	Zn binding site [ion binding]; other site
383372002973	Methyltransferase domain; Region: Methyltransf_26; pfam13659
383372002974	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372002975	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372002976	dimerization interface [polypeptide binding]; other site
383372002977	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372002978	dimer interface [polypeptide binding]; other site
383372002979	phosphorylation site [posttranslational modification]
383372002980	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372002981	ATP binding site [chemical binding]; other site
383372002982	Mg2+ binding site [ion binding]; other site
383372002983	G-X-G motif; other site
383372002984	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372002985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372002986	active site
383372002987	phosphorylation site [posttranslational modification]
383372002988	intermolecular recognition site; other site
383372002989	dimerization interface [polypeptide binding]; other site
383372002990	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372002991	DNA binding site [nucleotide binding]
383372002992	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
383372002993	Protein of unknown function (DUF461); Region: DUF461; pfam04314
383372002994	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
383372002995	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372002996	motif II; other site
383372002997	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
383372002998	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
383372002999	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
383372003000	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
383372003001	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
383372003002	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
383372003003	Walker A/P-loop; other site
383372003004	ATP binding site [chemical binding]; other site
383372003005	Q-loop/lid; other site
383372003006	ABC transporter signature motif; other site
383372003007	Walker B; other site
383372003008	D-loop; other site
383372003009	H-loop/switch region; other site
383372003010	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
383372003011	HD domain; Region: HD_4; pfam13328
383372003012	ADP-glucose phosphorylase; Region: PLN02643
383372003013	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
383372003014	nucleotide binding site/active site [active]
383372003015	HIT family signature motif; other site
383372003016	catalytic residue [active]
383372003017	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
383372003018	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
383372003019	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
383372003020	enoyl-CoA hydratase; Provisional; Region: PRK05995
383372003021	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
383372003022	substrate binding site [chemical binding]; other site
383372003023	oxyanion hole (OAH) forming residues; other site
383372003024	trimer interface [polypeptide binding]; other site
383372003025	aminoglycoside resistance protein; Provisional; Region: PRK13746
383372003026	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372003027	active site
383372003028	NTP binding site [chemical binding]; other site
383372003029	metal binding triad [ion binding]; metal-binding site
383372003030	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
383372003031	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
383372003032	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
383372003033	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
383372003034	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
383372003035	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
383372003036	carboxyltransferase (CT) interaction site; other site
383372003037	biotinylation site [posttranslational modification]; other site
383372003038	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
383372003039	homodimer interface [polypeptide binding]; other site
383372003040	catalytic residues [active]
383372003041	NAD binding site [chemical binding]; other site
383372003042	substrate binding pocket [chemical binding]; other site
383372003043	flexible flap; other site
383372003044	hypothetical protein; Provisional; Region: PRK04262
383372003045	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
383372003046	dimer interface [polypeptide binding]; other site
383372003047	active site
383372003048	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
383372003049	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
383372003050	active site
383372003051	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
383372003052	DUF35 OB-fold domain; Region: DUF35; pfam01796
383372003053	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
383372003054	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372003055	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372003056	DNA binding residues [nucleotide binding]
383372003057	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
383372003058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372003059	S-adenosylmethionine binding site [chemical binding]; other site
383372003060	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
383372003061	active site
383372003062	putative substrate binding region [chemical binding]; other site
383372003063	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
383372003064	triosephosphate isomerase; Provisional; Region: PRK14565
383372003065	substrate binding site [chemical binding]; other site
383372003066	dimer interface [polypeptide binding]; other site
383372003067	catalytic triad [active]
383372003068	Response regulator receiver domain; Region: Response_reg; pfam00072
383372003069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372003070	active site
383372003071	phosphorylation site [posttranslational modification]
383372003072	intermolecular recognition site; other site
383372003073	dimerization interface [polypeptide binding]; other site
383372003074	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
383372003075	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372003076	Walker A motif; other site
383372003077	ATP binding site [chemical binding]; other site
383372003078	Walker B motif; other site
383372003079	arginine finger; other site
383372003080	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
383372003081	GAF domain; Region: GAF_3; pfam13492
383372003082	GAF domain; Region: GAF_2; pfam13185
383372003083	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372003084	GAF domain; Region: GAF; pfam01590
383372003085	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372003086	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372003087	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
383372003088	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
383372003089	metal binding site [ion binding]; metal-binding site
383372003090	active site
383372003091	I-site; other site
383372003092	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372003093	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372003094	dimer interface [polypeptide binding]; other site
383372003095	phosphorylation site [posttranslational modification]
383372003096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372003097	ATP binding site [chemical binding]; other site
383372003098	Mg2+ binding site [ion binding]; other site
383372003099	G-X-G motif; other site
383372003100	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372003101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372003102	active site
383372003103	phosphorylation site [posttranslational modification]
383372003104	intermolecular recognition site; other site
383372003105	dimerization interface [polypeptide binding]; other site
383372003106	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372003107	DNA binding site [nucleotide binding]
383372003108	galactokinase; Provisional; Region: PRK05101
383372003109	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
383372003110	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
383372003111	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
383372003112	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
383372003113	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
383372003114	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
383372003115	Nuclease-related domain; Region: NERD; pfam08378
383372003116	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
383372003117	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
383372003118	L-aspartate oxidase; Provisional; Region: PRK06175
383372003119	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
383372003120	Quinolinate synthetase A protein; Region: NadA; pfam02445
383372003121	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
383372003122	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
383372003123	dimerization interface [polypeptide binding]; other site
383372003124	active site
383372003125	YcfA-like protein; Region: YcfA; pfam07927
383372003126	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
383372003127	Predicted transcriptional regulator [Transcription]; Region: COG2378
383372003128	HTH domain; Region: HTH_11; pfam08279
383372003129	WYL domain; Region: WYL; pfam13280
383372003130	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
383372003131	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
383372003132	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
383372003133	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
383372003134	CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905
383372003135	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372003136	active site
383372003137	NTP binding site [chemical binding]; other site
383372003138	metal binding triad [ion binding]; metal-binding site
383372003139	antibiotic binding site [chemical binding]; other site
383372003140	PUCC protein; Region: PUCC; pfam03209
383372003141	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
383372003142	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
383372003143	ATP binding site [chemical binding]; other site
383372003144	putative Mg++ binding site [ion binding]; other site
383372003145	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
383372003146	nucleotide binding region [chemical binding]; other site
383372003147	ATP-binding site [chemical binding]; other site
383372003148	DEAD/H associated; Region: DEAD_assoc; pfam08494
383372003149	Major Facilitator Superfamily; Region: MFS_1; pfam07690
383372003150	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372003151	putative substrate translocation pore; other site
383372003152	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372003153	S-adenosylmethionine binding site [chemical binding]; other site
383372003154	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372003155	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
383372003156	Ligand binding site; other site
383372003157	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
383372003158	Bacterial sugar transferase; Region: Bac_transf; pfam02397
383372003159	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
383372003160	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
383372003161	inhibitor-cofactor binding pocket; inhibition site
383372003162	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372003163	catalytic residue [active]
383372003164	diaminopimelate decarboxylase; Region: lysA; TIGR01048
383372003165	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
383372003166	active site
383372003167	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
383372003168	substrate binding site [chemical binding]; other site
383372003169	catalytic residues [active]
383372003170	dimer interface [polypeptide binding]; other site
383372003171	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
383372003172	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
383372003173	TrkA-C domain; Region: TrkA_C; pfam02080
383372003174	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
383372003175	dimer interface [polypeptide binding]; other site
383372003176	catalytic triad [active]
383372003177	peroxidatic and resolving cysteines [active]
383372003178	PAS domain; Region: PAS_8; pfam13188
383372003179	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372003180	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372003181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
383372003182	active site
383372003183	phosphorylation site [posttranslational modification]
383372003184	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
383372003185	DNA binding residues [nucleotide binding]
383372003186	dimerization interface [polypeptide binding]; other site
383372003187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372003188	H+ Antiporter protein; Region: 2A0121; TIGR00900
383372003189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
383372003190	active site
383372003191	phosphorylation site [posttranslational modification]
383372003192	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
383372003193	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372003194	DNA binding residues [nucleotide binding]
383372003195	dimerization interface [polypeptide binding]; other site
383372003196	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
383372003197	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
383372003198	metal binding triad [ion binding]; metal-binding site
383372003199	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
383372003200	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012
383372003201	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
383372003202	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
383372003203	active site
383372003204	catalytic tetrad [active]
383372003205	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
383372003206	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
383372003207	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
383372003208	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
383372003209	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
383372003210	RibD C-terminal domain; Region: RibD_C; cl17279
383372003211	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
383372003212	GAF domain; Region: GAF; pfam01590
383372003213	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372003214	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372003215	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372003216	dimer interface [polypeptide binding]; other site
383372003217	phosphorylation site [posttranslational modification]
383372003218	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372003219	ATP binding site [chemical binding]; other site
383372003220	Mg2+ binding site [ion binding]; other site
383372003221	G-X-G motif; other site
383372003222	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
383372003223	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
383372003224	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
383372003225	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
383372003226	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
383372003227	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
383372003228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372003229	dimer interface [polypeptide binding]; other site
383372003230	conserved gate region; other site
383372003231	putative PBP binding loops; other site
383372003232	ABC-ATPase subunit interface; other site
383372003233	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
383372003234	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
383372003235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372003236	dimer interface [polypeptide binding]; other site
383372003237	conserved gate region; other site
383372003238	putative PBP binding loops; other site
383372003239	ABC-ATPase subunit interface; other site
383372003240	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
383372003241	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
383372003242	Walker A/P-loop; other site
383372003243	ATP binding site [chemical binding]; other site
383372003244	Q-loop/lid; other site
383372003245	ABC transporter signature motif; other site
383372003246	Walker B; other site
383372003247	D-loop; other site
383372003248	H-loop/switch region; other site
383372003249	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
383372003250	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
383372003251	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
383372003252	Walker A/P-loop; other site
383372003253	ATP binding site [chemical binding]; other site
383372003254	Q-loop/lid; other site
383372003255	ABC transporter signature motif; other site
383372003256	Walker B; other site
383372003257	D-loop; other site
383372003258	H-loop/switch region; other site
383372003259	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
383372003260	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
383372003261	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
383372003262	Walker A/P-loop; other site
383372003263	ATP binding site [chemical binding]; other site
383372003264	Q-loop/lid; other site
383372003265	ABC transporter signature motif; other site
383372003266	Walker B; other site
383372003267	D-loop; other site
383372003268	H-loop/switch region; other site
383372003269	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
383372003270	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
383372003271	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
383372003272	Walker A/P-loop; other site
383372003273	ATP binding site [chemical binding]; other site
383372003274	Q-loop/lid; other site
383372003275	ABC transporter signature motif; other site
383372003276	Walker B; other site
383372003277	D-loop; other site
383372003278	H-loop/switch region; other site
383372003279	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
383372003280	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372003281	putative active site [active]
383372003282	Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802
383372003283	putative active site [active]
383372003284	YdjC motif; other site
383372003285	Mg binding site [ion binding]; other site
383372003286	homodimer interface [polypeptide binding]; other site
383372003287	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
383372003288	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
383372003289	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
383372003290	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
383372003291	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372003292	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
383372003293	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
383372003294	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
383372003295	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
383372003296	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
383372003297	5S rRNA interface [nucleotide binding]; other site
383372003298	CTC domain interface [polypeptide binding]; other site
383372003299	L16 interface [polypeptide binding]; other site
383372003300	LexA repressor; Validated; Region: PRK00215
383372003301	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
383372003302	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
383372003303	Catalytic site [active]
383372003304	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
383372003305	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
383372003306	hydroxyglutarate oxidase; Provisional; Region: PRK11728
383372003307	Methyltransferase domain; Region: Methyltransf_26; pfam13659
383372003308	recombination factor protein RarA; Reviewed; Region: PRK13342
383372003309	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372003310	Walker A motif; other site
383372003311	ATP binding site [chemical binding]; other site
383372003312	Walker B motif; other site
383372003313	arginine finger; other site
383372003314	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
383372003315	Predicted membrane protein [Function unknown]; Region: COG2261
383372003316	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
383372003317	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
383372003318	active site
383372003319	Zn binding site [ion binding]; other site
383372003320	thymidine kinase; Provisional; Region: PRK04296
383372003321	CoA binding domain; Region: CoA_binding; cl17356
383372003322	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
383372003323	DNA methylase; Region: N6_N4_Mtase; pfam01555
383372003324	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
383372003325	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
383372003326	Integral membrane protein DUF95; Region: DUF95; pfam01944
383372003327	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372003328	putative substrate translocation pore; other site
383372003329	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
383372003330	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
383372003331	active site
383372003332	cell division protein FtsZ; Validated; Region: PRK09330
383372003333	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
383372003334	nucleotide binding site [chemical binding]; other site
383372003335	SulA interaction site; other site
383372003336	cell division protein FtsA; Region: ftsA; TIGR01174
383372003337	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
383372003338	nucleotide binding site [chemical binding]; other site
383372003339	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
383372003340	Cell division protein FtsA; Region: FtsA; pfam14450
383372003341	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
383372003342	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
383372003343	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
383372003344	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
383372003345	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14649
383372003346	FAD binding domain; Region: FAD_binding_4; pfam01565
383372003347	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
383372003348	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372003349	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372003350	binding surface
383372003351	TPR motif; other site
383372003352	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372003353	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
383372003354	TPR motif; other site
383372003355	binding surface
383372003356	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
383372003357	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
383372003358	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
383372003359	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
383372003360	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
383372003361	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
383372003362	active site
383372003363	homodimer interface [polypeptide binding]; other site
383372003364	cell division protein FtsW; Region: ftsW; TIGR02614
383372003365	Rhomboid family; Region: Rhomboid; pfam01694
383372003366	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
383372003367	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
383372003368	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
383372003369	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
383372003370	Mg++ binding site [ion binding]; other site
383372003371	putative catalytic motif [active]
383372003372	putative substrate binding site [chemical binding]; other site
383372003373	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
383372003374	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
383372003375	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
383372003376	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
383372003377	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
383372003378	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
383372003379	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
383372003380	MraW methylase family; Region: Methyltransf_5; cl17771
383372003381	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
383372003382	cell division protein MraZ; Reviewed; Region: PRK00326
383372003383	MraZ protein; Region: MraZ; pfam02381
383372003384	MraZ protein; Region: MraZ; pfam02381
383372003385	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372003386	active site
383372003387	NTP binding site [chemical binding]; other site
383372003388	metal binding triad [ion binding]; metal-binding site
383372003389	antibiotic binding site [chemical binding]; other site
383372003390	Uncharacterized conserved protein [Function unknown]; Region: COG2445
383372003391	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372003392	AAA domain; Region: AAA_21; pfam13304
383372003393	Walker A/P-loop; other site
383372003394	ATP binding site [chemical binding]; other site
383372003395	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372003396	ABC transporter signature motif; other site
383372003397	Walker B; other site
383372003398	D-loop; other site
383372003399	H-loop/switch region; other site
383372003400	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
383372003401	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
383372003402	active site
383372003403	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
383372003404	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
383372003405	metal-binding site [ion binding]
383372003406	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
383372003407	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
383372003408	metal-binding site [ion binding]
383372003409	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
383372003410	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
383372003411	Soluble P-type ATPase [General function prediction only]; Region: COG4087
383372003412	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
383372003413	active site
383372003414	Ap6A binding site [chemical binding]; other site
383372003415	nudix motif; other site
383372003416	metal binding site [ion binding]; metal-binding site
383372003417	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14604
383372003418	RuvA N terminal domain; Region: RuvA_N; pfam01330
383372003419	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372003420	GAF domain; Region: GAF_3; pfam13492
383372003421	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372003422	PAS domain; Region: PAS_9; pfam13426
383372003423	putative active site [active]
383372003424	heme pocket [chemical binding]; other site
383372003425	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372003426	PAS fold; Region: PAS_3; pfam08447
383372003427	putative active site [active]
383372003428	heme pocket [chemical binding]; other site
383372003429	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372003430	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372003431	putative active site [active]
383372003432	heme pocket [chemical binding]; other site
383372003433	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372003434	dimer interface [polypeptide binding]; other site
383372003435	phosphorylation site [posttranslational modification]
383372003436	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372003437	ATP binding site [chemical binding]; other site
383372003438	Mg2+ binding site [ion binding]; other site
383372003439	G-X-G motif; other site
383372003440	Response regulator receiver domain; Region: Response_reg; pfam00072
383372003441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372003442	active site
383372003443	phosphorylation site [posttranslational modification]
383372003444	intermolecular recognition site; other site
383372003445	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
383372003446	dimerization interface [polypeptide binding]; other site
383372003447	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
383372003448	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
383372003449	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
383372003450	DXD motif; other site
383372003451	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
383372003452	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
383372003453	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
383372003454	anti sigma factor interaction site; other site
383372003455	regulatory phosphorylation site [posttranslational modification]; other site
383372003456	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
383372003457	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
383372003458	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
383372003459	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372003460	motif II; other site
383372003461	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
383372003462	Sensor protein DegS; Region: DegS; pfam05384
383372003463	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
383372003464	Histidine kinase; Region: HisKA_3; pfam07730
383372003465	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372003466	ATP binding site [chemical binding]; other site
383372003467	Mg2+ binding site [ion binding]; other site
383372003468	G-X-G motif; other site
383372003469	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
383372003470	Ligand binding site; other site
383372003471	Putative Catalytic site; other site
383372003472	DXD motif; other site
383372003473	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
383372003474	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
383372003475	FtsX-like permease family; Region: FtsX; pfam02687
383372003476	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
383372003477	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
383372003478	active site
383372003479	Riboflavin kinase; Region: Flavokinase; pfam01687
383372003480	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
383372003481	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
383372003482	RNA binding site [nucleotide binding]; other site
383372003483	active site
383372003484	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
383372003485	DHH family; Region: DHH; pfam01368
383372003486	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372003487	S-adenosylmethionine binding site [chemical binding]; other site
383372003488	Ribosome-binding factor A; Region: RBFA; pfam02033
383372003489	translation initiation factor IF-2; Region: IF-2; TIGR00487
383372003490	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
383372003491	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
383372003492	G1 box; other site
383372003493	putative GEF interaction site [polypeptide binding]; other site
383372003494	GTP/Mg2+ binding site [chemical binding]; other site
383372003495	Switch I region; other site
383372003496	G2 box; other site
383372003497	G3 box; other site
383372003498	Switch II region; other site
383372003499	G4 box; other site
383372003500	G5 box; other site
383372003501	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
383372003502	Translation-initiation factor 2; Region: IF-2; pfam11987
383372003503	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
383372003504	Protein of unknown function (DUF448); Region: DUF448; pfam04296
383372003505	putative RNA binding cleft [nucleotide binding]; other site
383372003506	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
383372003507	NusA N-terminal domain; Region: NusA_N; pfam08529
383372003508	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
383372003509	RNA binding site [nucleotide binding]; other site
383372003510	homodimer interface [polypeptide binding]; other site
383372003511	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
383372003512	G-X-X-G motif; other site
383372003513	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
383372003514	G-X-X-G motif; other site
383372003515	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
383372003516	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
383372003517	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372003518	Walker A motif; other site
383372003519	ATP binding site [chemical binding]; other site
383372003520	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
383372003521	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
383372003522	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
383372003523	NAD(P) binding site [chemical binding]; other site
383372003524	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
383372003525	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
383372003526	Histidine kinase; Region: HisKA_3; pfam07730
383372003527	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372003528	ATP binding site [chemical binding]; other site
383372003529	Mg2+ binding site [ion binding]; other site
383372003530	G-X-G motif; other site
383372003531	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372003532	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372003533	active site
383372003534	phosphorylation site [posttranslational modification]
383372003535	intermolecular recognition site; other site
383372003536	dimerization interface [polypeptide binding]; other site
383372003537	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372003538	DNA binding residues [nucleotide binding]
383372003539	dimerization interface [polypeptide binding]; other site
383372003540	DUF218 domain; Region: DUF218; pfam02698
383372003541	putative active site [active]
383372003542	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
383372003543	hypothetical protein; Provisional; Region: PRK01346
383372003544	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372003545	Coenzyme A binding pocket [chemical binding]; other site
383372003546	Sterol carrier protein domain; Region: SCP2_2; pfam13530
383372003547	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
383372003548	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
383372003549	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
383372003550	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
383372003551	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
383372003552	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
383372003553	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
383372003554	Bacterial SH3 domain; Region: SH3_3; pfam08239
383372003555	Bacterial SH3 domain; Region: SH3_3; pfam08239
383372003556	Bacterial SH3 domain; Region: SH3_3; pfam08239
383372003557	pyrroline-5-carboxylate reductase; Region: PLN02688
383372003558	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
383372003559	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
383372003560	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
383372003561	dimer interface [polypeptide binding]; other site
383372003562	active site
383372003563	glycine-pyridoxal phosphate binding site [chemical binding]; other site
383372003564	folate binding site [chemical binding]; other site
383372003565	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372003566	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
383372003567	NAD(P) binding site [chemical binding]; other site
383372003568	active site
383372003569	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
383372003570	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
383372003571	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
383372003572	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
383372003573	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
383372003574	active site
383372003575	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
383372003576	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
383372003577	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
383372003578	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372003579	PAS domain; Region: PAS_9; pfam13426
383372003580	putative active site [active]
383372003581	heme pocket [chemical binding]; other site
383372003582	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
383372003583	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
383372003584	metal binding site [ion binding]; metal-binding site
383372003585	active site
383372003586	I-site; other site
383372003587	Protein of unknown function DUF111; Region: DUF111; pfam01969
383372003588	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
383372003589	putative active site [active]
383372003590	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
383372003591	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
383372003592	putative active site [active]
383372003593	homotetrameric interface [polypeptide binding]; other site
383372003594	metal binding site [ion binding]; metal-binding site
383372003595	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
383372003596	DNA methylase; Region: N6_N4_Mtase; cl17433
383372003597	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
383372003598	DNA methylase; Region: N6_N4_Mtase; pfam01555
383372003599	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
383372003600	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372003601	dimer interface [polypeptide binding]; other site
383372003602	conserved gate region; other site
383372003603	putative PBP binding loops; other site
383372003604	ABC-ATPase subunit interface; other site
383372003605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
383372003606	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372003607	ABC-ATPase subunit interface; other site
383372003608	putative PBP binding loops; other site
383372003609	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
383372003610	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
383372003611	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372003612	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372003613	dimerization interface [polypeptide binding]; other site
383372003614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372003615	ATP binding site [chemical binding]; other site
383372003616	Mg2+ binding site [ion binding]; other site
383372003617	G-X-G motif; other site
383372003618	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372003619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372003620	active site
383372003621	phosphorylation site [posttranslational modification]
383372003622	intermolecular recognition site; other site
383372003623	dimerization interface [polypeptide binding]; other site
383372003624	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372003625	DNA binding site [nucleotide binding]
383372003626	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
383372003627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372003628	S-adenosylmethionine binding site [chemical binding]; other site
383372003629	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
383372003630	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372003631	FeS/SAM binding site; other site
383372003632	Domain of unknown function DUF59; Region: DUF59; cl00941
383372003633	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372003634	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
383372003635	Walker A/P-loop; other site
383372003636	ATP binding site [chemical binding]; other site
383372003637	Q-loop/lid; other site
383372003638	ABC transporter signature motif; other site
383372003639	Walker B; other site
383372003640	D-loop; other site
383372003641	H-loop/switch region; other site
383372003642	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
383372003643	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
383372003644	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
383372003645	high affinity sulphate transporter 1; Region: sulP; TIGR00815
383372003646	Sulfate transporter family; Region: Sulfate_transp; pfam00916
383372003647	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
383372003648	Putative phosphatase (DUF442); Region: DUF442; cl17385
383372003649	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
383372003650	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
383372003651	CPxP  motif; other site
383372003652	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
383372003653	active site residue [active]
383372003654	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
383372003655	Cytochrome c; Region: Cytochrom_C; pfam00034
383372003656	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
383372003657	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
383372003658	RNA/DNA hybrid binding site [nucleotide binding]; other site
383372003659	active site
383372003660	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372003661	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372003662	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372003663	exopolyphosphatase; Region: exo_poly_only; TIGR03706
383372003664	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
383372003665	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
383372003666	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
383372003667	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
383372003668	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
383372003669	anti sigma factor interaction site; other site
383372003670	regulatory phosphorylation site [posttranslational modification]; other site
383372003671	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
383372003672	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
383372003673	ATP binding site [chemical binding]; other site
383372003674	Mg2+ binding site [ion binding]; other site
383372003675	G-X-G motif; other site
383372003676	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
383372003677	anti sigma factor interaction site; other site
383372003678	regulatory phosphorylation site [posttranslational modification]; other site
383372003679	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372003680	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372003681	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372003682	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372003683	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372003684	GAF domain; Region: GAF; pfam01590
383372003685	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
383372003686	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
383372003687	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
383372003688	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
383372003689	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
383372003690	nucleophile elbow; other site
383372003691	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
383372003692	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
383372003693	Clp amino terminal domain; Region: Clp_N; pfam02861
383372003694	Clp amino terminal domain; Region: Clp_N; pfam02861
383372003695	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372003696	Walker A motif; other site
383372003697	ATP binding site [chemical binding]; other site
383372003698	Walker B motif; other site
383372003699	arginine finger; other site
383372003700	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372003701	Walker A motif; other site
383372003702	ATP binding site [chemical binding]; other site
383372003703	Walker B motif; other site
383372003704	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
383372003705	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
383372003706	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
383372003707	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
383372003708	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
383372003709	HlyD family secretion protein; Region: HlyD_3; pfam13437
383372003710	Ferrochelatase; Region: Ferrochelatase; pfam00762
383372003711	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
383372003712	active site
383372003713	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
383372003714	active site
383372003715	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
383372003716	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
383372003717	glutaminase active site [active]
383372003718	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
383372003719	dimer interface [polypeptide binding]; other site
383372003720	active site
383372003721	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
383372003722	dimer interface [polypeptide binding]; other site
383372003723	active site
383372003724	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372003725	active site
383372003726	NTP binding site [chemical binding]; other site
383372003727	metal binding triad [ion binding]; metal-binding site
383372003728	antibiotic binding site [chemical binding]; other site
383372003729	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
383372003730	hypothetical protein; Provisional; Region: PRK08912
383372003731	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
383372003732	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372003733	homodimer interface [polypeptide binding]; other site
383372003734	catalytic residue [active]
383372003735	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
383372003736	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372003737	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
383372003738	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
383372003739	ring oligomerisation interface [polypeptide binding]; other site
383372003740	ATP/Mg binding site [chemical binding]; other site
383372003741	stacking interactions; other site
383372003742	hinge regions; other site
383372003743	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
383372003744	oligomerisation interface [polypeptide binding]; other site
383372003745	mobile loop; other site
383372003746	roof hairpin; other site
383372003747	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
383372003748	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
383372003749	putative active site [active]
383372003750	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
383372003751	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
383372003752	substrate binding site; other site
383372003753	metal-binding site
383372003754	Oligomer interface; other site
383372003755	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
383372003756	Bacterial SH3 domain; Region: SH3_3; pfam08239
383372003757	Bacterial SH3 domain homologues; Region: SH3b; smart00287
383372003758	Bacterial SH3 domain; Region: SH3_3; pfam08239
383372003759	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
383372003760	NlpC/P60 family; Region: NLPC_P60; pfam00877
383372003761	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
383372003762	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
383372003763	active site
383372003764	catalytic site [active]
383372003765	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
383372003766	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
383372003767	active site
383372003768	substrate binding site [chemical binding]; other site
383372003769	metal binding site [ion binding]; metal-binding site
383372003770	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
383372003771	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
383372003772	Zn2+ binding site [ion binding]; other site
383372003773	Mg2+ binding site [ion binding]; other site
383372003774	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
383372003775	synthetase active site [active]
383372003776	NTP binding site [chemical binding]; other site
383372003777	metal binding site [ion binding]; metal-binding site
383372003778	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
383372003779	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
383372003780	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
383372003781	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
383372003782	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
383372003783	putative active site [active]
383372003784	Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131
383372003785	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
383372003786	NAD binding site [chemical binding]; other site
383372003787	catalytic residues [active]
383372003788	Methyltransferase domain; Region: Methyltransf_31; pfam13847
383372003789	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372003790	S-adenosylmethionine binding site [chemical binding]; other site
383372003791	acetylornithine aminotransferase; Provisional; Region: PRK02627
383372003792	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
383372003793	inhibitor-cofactor binding pocket; inhibition site
383372003794	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372003795	catalytic residue [active]
383372003796	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
383372003797	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
383372003798	active site
383372003799	metal binding site [ion binding]; metal-binding site
383372003800	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
383372003801	HAS barrel domain; Region: HAS-barrel; pfam09378
383372003802	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372003803	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372003804	DNA binding residues [nucleotide binding]
383372003805	dimerization interface [polypeptide binding]; other site
383372003806	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
383372003807	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
383372003808	protein binding site [polypeptide binding]; other site
383372003809	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
383372003810	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
383372003811	protein binding site [polypeptide binding]; other site
383372003812	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
383372003813	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
383372003814	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
383372003815	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
383372003816	Walker A/P-loop; other site
383372003817	ATP binding site [chemical binding]; other site
383372003818	Q-loop/lid; other site
383372003819	ABC transporter signature motif; other site
383372003820	Walker B; other site
383372003821	D-loop; other site
383372003822	H-loop/switch region; other site
383372003823	TOBE domain; Region: TOBE_2; pfam08402
383372003824	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
383372003825	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
383372003826	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
383372003827	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
383372003828	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
383372003829	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
383372003830	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372003831	putative PBP binding loops; other site
383372003832	ABC-ATPase subunit interface; other site
383372003833	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
383372003834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372003835	dimer interface [polypeptide binding]; other site
383372003836	conserved gate region; other site
383372003837	putative PBP binding loops; other site
383372003838	ABC-ATPase subunit interface; other site
383372003839	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
383372003840	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372003841	Walker A/P-loop; other site
383372003842	ATP binding site [chemical binding]; other site
383372003843	Q-loop/lid; other site
383372003844	ABC transporter signature motif; other site
383372003845	Walker B; other site
383372003846	D-loop; other site
383372003847	H-loop/switch region; other site
383372003848	TOBE domain; Region: TOBE_2; pfam08402
383372003849	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
383372003850	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
383372003851	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372003852	Right handed beta helix region; Region: Beta_helix; pfam13229
383372003853	Right handed beta helix region; Region: Beta_helix; pfam13229
383372003854	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
383372003855	isocitrate dehydrogenase; Validated; Region: PRK06451
383372003856	FOG: CBS domain [General function prediction only]; Region: COG0517
383372003857	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
383372003858	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
383372003859	apolar tunnel; other site
383372003860	heme binding site [chemical binding]; other site
383372003861	dimerization interface [polypeptide binding]; other site
383372003862	Sulfatase; Region: Sulfatase; cl17466
383372003863	HEAT repeats; Region: HEAT_2; pfam13646
383372003864	GxxExxY protein; Region: GxxExxY; TIGR04256
383372003865	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
383372003866	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
383372003867	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
383372003868	active site
383372003869	catalytic site [active]
383372003870	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
383372003871	nudix motif; other site
383372003872	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
383372003873	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
383372003874	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
383372003875	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
383372003876	Walker A/P-loop; other site
383372003877	ATP binding site [chemical binding]; other site
383372003878	Q-loop/lid; other site
383372003879	ABC transporter signature motif; other site
383372003880	Walker B; other site
383372003881	D-loop; other site
383372003882	H-loop/switch region; other site
383372003883	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
383372003884	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
383372003885	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372003886	Walker A/P-loop; other site
383372003887	ATP binding site [chemical binding]; other site
383372003888	Q-loop/lid; other site
383372003889	ABC transporter signature motif; other site
383372003890	Walker B; other site
383372003891	D-loop; other site
383372003892	H-loop/switch region; other site
383372003893	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
383372003894	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
383372003895	NADP binding site [chemical binding]; other site
383372003896	homodimer interface [polypeptide binding]; other site
383372003897	active site
383372003898	KduI/IolB family; Region: KduI; pfam04962
383372003899	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
383372003900	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
383372003901	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
383372003902	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
383372003903	XdhC Rossmann domain; Region: XdhC_C; pfam13478
383372003904	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
383372003905	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
383372003906	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
383372003907	NodB motif; other site
383372003908	active site
383372003909	metal binding site [ion binding]; metal-binding site
383372003910	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372003911	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372003912	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372003913	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372003914	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372003915	Protein of unknown function (DUF402); Region: DUF402; pfam04167
383372003916	Methyltransferase domain; Region: Methyltransf_11; pfam08241
383372003917	rod shape-determining protein MreB; Provisional; Region: PRK13930
383372003918	MreB and similar proteins; Region: MreB_like; cd10225
383372003919	nucleotide binding site [chemical binding]; other site
383372003920	Mg binding site [ion binding]; other site
383372003921	putative protofilament interaction site [polypeptide binding]; other site
383372003922	RodZ interaction site [polypeptide binding]; other site
383372003923	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735
383372003924	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
383372003925	gamma subunit interface [polypeptide binding]; other site
383372003926	epsilon subunit interface [polypeptide binding]; other site
383372003927	LBP interface [polypeptide binding]; other site
383372003928	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
383372003929	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
383372003930	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
383372003931	alpha subunit interaction interface [polypeptide binding]; other site
383372003932	Walker A motif; other site
383372003933	ATP binding site [chemical binding]; other site
383372003934	Walker B motif; other site
383372003935	inhibitor binding site; inhibition site
383372003936	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
383372003937	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
383372003938	core domain interface [polypeptide binding]; other site
383372003939	delta subunit interface [polypeptide binding]; other site
383372003940	epsilon subunit interface [polypeptide binding]; other site
383372003941	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
383372003942	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
383372003943	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
383372003944	beta subunit interaction interface [polypeptide binding]; other site
383372003945	Walker A motif; other site
383372003946	ATP binding site [chemical binding]; other site
383372003947	Walker B motif; other site
383372003948	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
383372003949	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
383372003950	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
383372003951	F0F1 ATP synthase subunit B; Provisional; Region: PRK14473
383372003952	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
383372003953	ATP synthase subunit C; Region: ATP-synt_C; cl00466
383372003954	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
383372003955	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372003956	active site
383372003957	phosphorylation site [posttranslational modification]
383372003958	intermolecular recognition site; other site
383372003959	dimerization interface [polypeptide binding]; other site
383372003960	Response regulator receiver domain; Region: Response_reg; pfam00072
383372003961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372003962	active site
383372003963	phosphorylation site [posttranslational modification]
383372003964	intermolecular recognition site; other site
383372003965	dimerization interface [polypeptide binding]; other site
383372003966	GAF domain; Region: GAF_2; pfam13185
383372003967	GAF domain; Region: GAF_3; pfam13492
383372003968	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372003969	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372003970	dimer interface [polypeptide binding]; other site
383372003971	phosphorylation site [posttranslational modification]
383372003972	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372003973	ATP binding site [chemical binding]; other site
383372003974	Mg2+ binding site [ion binding]; other site
383372003975	G-X-G motif; other site
383372003976	PspC domain; Region: PspC; pfam04024
383372003977	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
383372003978	Transcriptional regulators [Transcription]; Region: PurR; COG1609
383372003979	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
383372003980	DNA binding site [nucleotide binding]
383372003981	domain linker motif; other site
383372003982	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
383372003983	dimerization interface [polypeptide binding]; other site
383372003984	ligand binding site [chemical binding]; other site
383372003985	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
383372003986	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
383372003987	Walker A/P-loop; other site
383372003988	ATP binding site [chemical binding]; other site
383372003989	Q-loop/lid; other site
383372003990	ABC transporter signature motif; other site
383372003991	Walker B; other site
383372003992	D-loop; other site
383372003993	H-loop/switch region; other site
383372003994	TOBE domain; Region: TOBE; pfam03459
383372003995	Domain of unknown function (DUF385); Region: DUF385; cl04387
383372003996	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
383372003997	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
383372003998	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
383372003999	non-specific DNA binding site [nucleotide binding]; other site
383372004000	salt bridge; other site
383372004001	sequence-specific DNA binding site [nucleotide binding]; other site
383372004002	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
383372004003	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
383372004004	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
383372004005	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
383372004006	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
383372004007	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372004008	FeS/SAM binding site; other site
383372004009	Penicillinase repressor; Region: Pencillinase_R; pfam03965
383372004010	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
383372004011	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
383372004012	substrate binding pocket [chemical binding]; other site
383372004013	chain length determination region; other site
383372004014	substrate-Mg2+ binding site; other site
383372004015	catalytic residues [active]
383372004016	aspartate-rich region 1; other site
383372004017	active site lid residues [active]
383372004018	aspartate-rich region 2; other site
383372004019	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372004020	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372004021	DDE superfamily endonuclease; Region: DDE_3; pfam13358
383372004022	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372004023	putative substrate translocation pore; other site
383372004024	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372004025	GTPase Era; Reviewed; Region: era; PRK00089
383372004026	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
383372004027	G1 box; other site
383372004028	GTP/Mg2+ binding site [chemical binding]; other site
383372004029	Switch I region; other site
383372004030	G2 box; other site
383372004031	Switch II region; other site
383372004032	G3 box; other site
383372004033	G4 box; other site
383372004034	G5 box; other site
383372004035	KH domain; Region: KH_2; pfam07650
383372004036	Methyltransferase domain; Region: Methyltransf_26; pfam13659
383372004037	DNA methylase; Region: N6_N4_Mtase; cl17433
383372004038	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
383372004039	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
383372004040	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372004041	S-adenosylmethionine binding site [chemical binding]; other site
383372004042	pantothenate kinase; Reviewed; Region: PRK13318
383372004043	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
383372004044	active site
383372004045	homotetramer interface [polypeptide binding]; other site
383372004046	homodimer interface [polypeptide binding]; other site
383372004047	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
383372004048	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372004049	S-adenosylmethionine binding site [chemical binding]; other site
383372004050	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372004051	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372004052	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372004053	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372004054	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372004055	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372004056	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372004057	MG2 domain; Region: A2M_N; pfam01835
383372004058	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
383372004059	Alpha-2-macroglobulin family; Region: A2M; pfam00207
383372004060	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
383372004061	surface patch; other site
383372004062	thioester region; other site
383372004063	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
383372004064	specificity defining residues; other site
383372004065	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372004066	active site
383372004067	NTP binding site [chemical binding]; other site
383372004068	metal binding triad [ion binding]; metal-binding site
383372004069	antibiotic binding site [chemical binding]; other site
383372004070	HEPN domain; Region: HEPN; pfam05168
383372004071	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
383372004072	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
383372004073	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
383372004074	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
383372004075	active site
383372004076	metal binding site [ion binding]; metal-binding site
383372004077	DNA binding site [nucleotide binding]
383372004078	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
383372004079	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
383372004080	active site
383372004081	Domain of unknown function (DUF955); Region: DUF955; cl01076
383372004082	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
383372004083	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
383372004084	Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564
383372004085	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
383372004086	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
383372004087	Ligand Binding Site [chemical binding]; other site
383372004088	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
383372004089	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
383372004090	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
383372004091	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
383372004092	Soluble P-type ATPase [General function prediction only]; Region: COG4087
383372004093	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
383372004094	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
383372004095	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
383372004096	putative dimer interface [polypeptide binding]; other site
383372004097	[2Fe-2S] cluster binding site [ion binding]; other site
383372004098	NADH dehydrogenase subunit D; Validated; Region: PRK06075
383372004099	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
383372004100	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
383372004101	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
383372004102	NADH dehydrogenase subunit B; Validated; Region: PRK06411
383372004103	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
383372004104	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
383372004105	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
383372004106	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
383372004107	DNA binding site [nucleotide binding]
383372004108	active site
383372004109	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
383372004110	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372004111	Probable Catalytic site; other site
383372004112	metal-binding site
383372004113	Septum formation initiator; Region: DivIC; pfam04977
383372004114	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
383372004115	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
383372004116	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
383372004117	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
383372004118	active site clefts [active]
383372004119	zinc binding site [ion binding]; other site
383372004120	dimer interface [polypeptide binding]; other site
383372004121	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
383372004122	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
383372004123	catalytic triad [active]
383372004124	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372004125	putative active site [active]
383372004126	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372004127	putative active site [active]
383372004128	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
383372004129	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
383372004130	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
383372004131	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
383372004132	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
383372004133	putative active site [active]
383372004134	putative metal binding site [ion binding]; other site
383372004135	Membrane protein of unknown function; Region: DUF360; pfam04020
383372004136	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
383372004137	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
383372004138	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
383372004139	putative active site [active]
383372004140	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
383372004141	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
383372004142	putative trimer interface [polypeptide binding]; other site
383372004143	putative CoA binding site [chemical binding]; other site
383372004144	Bacterial sugar transferase; Region: Bac_transf; pfam02397
383372004145	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372004146	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
383372004147	putative ADP-binding pocket [chemical binding]; other site
383372004148	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372004149	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372004150	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372004151	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372004152	Probable Catalytic site; other site
383372004153	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
383372004154	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
383372004155	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372004156	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372004157	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372004158	O-Antigen ligase; Region: Wzy_C; pfam04932
383372004159	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
383372004160	Chain length determinant protein; Region: Wzz; pfam02706
383372004161	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
383372004162	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
383372004163	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372004164	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372004165	active site
383372004166	phosphorylation site [posttranslational modification]
383372004167	intermolecular recognition site; other site
383372004168	dimerization interface [polypeptide binding]; other site
383372004169	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372004170	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372004171	active site
383372004172	phosphorylation site [posttranslational modification]
383372004173	intermolecular recognition site; other site
383372004174	dimerization interface [polypeptide binding]; other site
383372004175	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372004176	DNA binding residues [nucleotide binding]
383372004177	dimerization interface [polypeptide binding]; other site
383372004178	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
383372004179	Histidine kinase; Region: HisKA_3; pfam07730
383372004180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372004181	ATP binding site [chemical binding]; other site
383372004182	Mg2+ binding site [ion binding]; other site
383372004183	G-X-G motif; other site
383372004184	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
383372004185	active site
383372004186	catalytic site [active]
383372004187	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372004188	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372004189	binding surface
383372004190	TPR motif; other site
383372004191	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372004192	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372004193	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
383372004194	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
383372004195	NAD(P) binding site [chemical binding]; other site
383372004196	homodimer interface [polypeptide binding]; other site
383372004197	substrate binding site [chemical binding]; other site
383372004198	active site
383372004199	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
383372004200	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
383372004201	inhibitor-cofactor binding pocket; inhibition site
383372004202	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372004203	catalytic residue [active]
383372004204	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372004205	metal ion-dependent adhesion site (MIDAS); other site
383372004206	CARDB; Region: CARDB; pfam07705
383372004207	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1; cd01653
383372004208	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
383372004209	metal ion-dependent adhesion site (MIDAS); other site
383372004210	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
383372004211	bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571
383372004212	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
383372004213	putative dimer interface [polypeptide binding]; other site
383372004214	[2Fe-2S] cluster binding site [ion binding]; other site
383372004215	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
383372004216	dimer interface [polypeptide binding]; other site
383372004217	[2Fe-2S] cluster binding site [ion binding]; other site
383372004218	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
383372004219	SLBB domain; Region: SLBB; pfam10531
383372004220	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
383372004221	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
383372004222	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
383372004223	catalytic loop [active]
383372004224	iron binding site [ion binding]; other site
383372004225	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
383372004226	4Fe-4S binding domain; Region: Fer4; cl02805
383372004227	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
383372004228	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
383372004229	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
383372004230	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
383372004231	nickel binding site [ion binding]; other site
383372004232	Thioredoxin; Region: Thioredoxin_4; pfam13462
383372004233	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
383372004234	PAS domain S-box; Region: sensory_box; TIGR00229
383372004235	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372004236	putative active site [active]
383372004237	heme pocket [chemical binding]; other site
383372004238	PAS fold; Region: PAS_4; pfam08448
383372004239	PAS domain S-box; Region: sensory_box; TIGR00229
383372004240	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372004241	putative active site [active]
383372004242	heme pocket [chemical binding]; other site
383372004243	PAS fold; Region: PAS_4; pfam08448
383372004244	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372004245	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
383372004246	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
383372004247	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
383372004248	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
383372004249	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
383372004250	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
383372004251	Dynamin family; Region: Dynamin_N; pfam00350
383372004252	G1 box; other site
383372004253	GTP/Mg2+ binding site [chemical binding]; other site
383372004254	G2 box; other site
383372004255	Switch I region; other site
383372004256	G3 box; other site
383372004257	Switch II region; other site
383372004258	G4 box; other site
383372004259	G5 box; other site
383372004260	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
383372004261	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
383372004262	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
383372004263	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
383372004264	hypothetical protein; Provisional; Region: PRK05325
383372004265	SpoVR like protein; Region: SpoVR; pfam04293
383372004266	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
383372004267	Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
383372004268	thioester formation/cholesterol transfer; other site
383372004269	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
383372004270	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
383372004271	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
383372004272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372004273	S-adenosylmethionine binding site [chemical binding]; other site
383372004274	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
383372004275	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
383372004276	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
383372004277	NAD binding site [chemical binding]; other site
383372004278	sugar binding site [chemical binding]; other site
383372004279	divalent metal binding site [ion binding]; other site
383372004280	tetramer (dimer of dimers) interface [polypeptide binding]; other site
383372004281	dimer interface [polypeptide binding]; other site
383372004282	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
383372004283	active site
383372004284	NAD binding site [chemical binding]; other site
383372004285	metal binding site [ion binding]; metal-binding site
383372004286	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
383372004287	additional DNA contacts [nucleotide binding]; other site
383372004288	mismatch recognition site; other site
383372004289	active site
383372004290	zinc binding site [ion binding]; other site
383372004291	DNA intercalation site [nucleotide binding]; other site
383372004292	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
383372004293	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
383372004294	cofactor binding site; other site
383372004295	DNA binding site [nucleotide binding]
383372004296	substrate interaction site [chemical binding]; other site
383372004297	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
383372004298	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
383372004299	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
383372004300	CoA binding domain; Region: CoA_binding; smart00881
383372004301	envelope glycoprotein C; Provisional; Region: PHA03269
383372004302	envelope glycoprotein C; Provisional; Region: PHA03269
383372004303	AAA-like domain; Region: AAA_10; pfam12846
383372004304	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
383372004305	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
383372004306	Peptidase family M23; Region: Peptidase_M23; pfam01551
383372004307	Peptidase family M23; Region: Peptidase_M23; pfam01551
383372004308	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
383372004309	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
383372004310	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
383372004311	Walker A motif; other site
383372004312	ATP binding site [chemical binding]; other site
383372004313	Walker B motif; other site
383372004314	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
383372004315	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
383372004316	Walker A motif; other site
383372004317	ATP binding site [chemical binding]; other site
383372004318	Walker B motif; other site
383372004319	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
383372004320	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
383372004321	TadE-like protein; Region: TadE; pfam07811
383372004322	conserved repeat domain; Region: B_ant_repeat; TIGR01451
383372004323	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
383372004324	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
383372004325	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372004326	transaminase; Validated; Region: PRK07324
383372004327	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
383372004328	FemAB family; Region: FemAB; pfam02388
383372004329	HEAT repeats; Region: HEAT_2; pfam13646
383372004330	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
383372004331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
383372004332	Walker A motif; other site
383372004333	ATP binding site [chemical binding]; other site
383372004334	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
383372004335	metal ion-dependent adhesion site (MIDAS); other site
383372004336	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
383372004337	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
383372004338	RNA binding site [nucleotide binding]; other site
383372004339	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
383372004340	RNA binding site [nucleotide binding]; other site
383372004341	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
383372004342	RNA binding site [nucleotide binding]; other site
383372004343	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
383372004344	Ribonuclease P; Region: Ribonuclease_P; pfam00825
383372004345	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
383372004346	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
383372004347	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
383372004348	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
383372004349	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
383372004350	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
383372004351	G-X-X-G motif; other site
383372004352	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
383372004353	RxxxH motif; other site
383372004354	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
383372004355	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
383372004356	ATP binding site [chemical binding]; other site
383372004357	substrate binding site [chemical binding]; other site
383372004358	Putative transcription activator [Transcription]; Region: TenA; COG0819
383372004359	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
383372004360	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
383372004361	translation initiation factor IF-3; Region: infC; TIGR00168
383372004362	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
383372004363	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
383372004364	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
383372004365	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
383372004366	23S rRNA binding site [nucleotide binding]; other site
383372004367	L21 binding site [polypeptide binding]; other site
383372004368	L13 binding site [polypeptide binding]; other site
383372004369	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
383372004370	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
383372004371	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
383372004372	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
383372004373	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
383372004374	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
383372004375	dimer interface [polypeptide binding]; other site
383372004376	motif 1; other site
383372004377	active site
383372004378	motif 2; other site
383372004379	motif 3; other site
383372004380	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
383372004381	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
383372004382	putative tRNA-binding site [nucleotide binding]; other site
383372004383	B3/4 domain; Region: B3_4; pfam03483
383372004384	tRNA synthetase B5 domain; Region: B5; pfam03484
383372004385	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
383372004386	dimer interface [polypeptide binding]; other site
383372004387	motif 1; other site
383372004388	motif 3; other site
383372004389	motif 2; other site
383372004390	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
383372004391	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372004392	putative active site [active]
383372004393	Winged helix-turn helix; Region: HTH_29; pfam13551
383372004394	Helix-turn-helix domain; Region: HTH_28; pfam13518
383372004395	CHAT domain; Region: CHAT; cl17868
383372004396	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
383372004397	amidase catalytic site [active]
383372004398	Zn binding residues [ion binding]; other site
383372004399	substrate binding site [chemical binding]; other site
383372004400	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
383372004401	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
383372004402	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
383372004403	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
383372004404	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
383372004405	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
383372004406	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
383372004407	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
383372004408	trimer interface [polypeptide binding]; other site
383372004409	putative metal binding site [ion binding]; other site
383372004410	Tic20-like protein; Region: Tic20; pfam09685
383372004411	MoxR-like ATPases [General function prediction only]; Region: COG0714
383372004412	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
383372004413	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
383372004414	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372004415	metal ion-dependent adhesion site (MIDAS); other site
383372004416	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
383372004417	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
383372004418	substrate binding pocket [chemical binding]; other site
383372004419	membrane-bound complex binding site; other site
383372004420	hinge residues; other site
383372004421	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
383372004422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372004423	conserved gate region; other site
383372004424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372004425	dimer interface [polypeptide binding]; other site
383372004426	conserved gate region; other site
383372004427	putative PBP binding loops; other site
383372004428	ABC-ATPase subunit interface; other site
383372004429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372004430	dimer interface [polypeptide binding]; other site
383372004431	conserved gate region; other site
383372004432	putative PBP binding loops; other site
383372004433	ABC-ATPase subunit interface; other site
383372004434	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
383372004435	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
383372004436	Walker A/P-loop; other site
383372004437	ATP binding site [chemical binding]; other site
383372004438	Q-loop/lid; other site
383372004439	ABC transporter signature motif; other site
383372004440	Walker B; other site
383372004441	D-loop; other site
383372004442	H-loop/switch region; other site
383372004443	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
383372004444	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
383372004445	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
383372004446	agmatinase; Region: agmatinase; TIGR01230
383372004447	Arginase family; Region: Arginase; cd09989
383372004448	active site
383372004449	Mn binding site [ion binding]; other site
383372004450	oligomer interface [polypeptide binding]; other site
383372004451	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
383372004452	heme-binding residues [chemical binding]; other site
383372004453	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
383372004454	molybdopterin cofactor binding site; other site
383372004455	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
383372004456	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
383372004457	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
383372004458	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
383372004459	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
383372004460	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
383372004461	Transposase IS200 like; Region: Y1_Tnp; pfam01797
383372004462	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
383372004463	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
383372004464	active site
383372004465	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
383372004466	active site
383372004467	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
383372004468	Homeodomain-like domain; Region: HTH_23; cl17451
383372004469	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
383372004470	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
383372004471	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
383372004472	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372004473	Walker A motif; other site
383372004474	ATP binding site [chemical binding]; other site
383372004475	Walker B motif; other site
383372004476	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
383372004477	Clp protease; Region: CLP_protease; pfam00574
383372004478	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
383372004479	oligomer interface [polypeptide binding]; other site
383372004480	active site residues [active]
383372004481	trigger factor; Provisional; Region: tig; PRK01490
383372004482	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
383372004483	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
383372004484	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
383372004485	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
383372004486	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
383372004487	ATP binding site [chemical binding]; other site
383372004488	putative Mg++ binding site [ion binding]; other site
383372004489	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
383372004490	nucleotide binding region [chemical binding]; other site
383372004491	ATP-binding site [chemical binding]; other site
383372004492	TRCF domain; Region: TRCF; pfam03461
383372004493	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372004494	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372004495	active site
383372004496	ATP binding site [chemical binding]; other site
383372004497	substrate binding site [chemical binding]; other site
383372004498	activation loop (A-loop); other site
383372004499	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372004500	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372004501	phosphopeptide binding site; other site
383372004502	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372004503	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372004504	DNA binding site [nucleotide binding]
383372004505	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
383372004506	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
383372004507	hinge; other site
383372004508	active site
383372004509	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
383372004510	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
383372004511	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
383372004512	catalytic triad [active]
383372004513	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
383372004514	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372004515	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
383372004516	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
383372004517	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
383372004518	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372004519	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372004520	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372004521	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
383372004522	Protein of unknown function (DUF970); Region: DUF970; cl17525
383372004523	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
383372004524	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
383372004525	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
383372004526	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
383372004527	dimer interface [polypeptide binding]; other site
383372004528	active site
383372004529	Src Homology 3 domain superfamily; Region: SH3; cl17036
383372004530	peptide ligand binding site [polypeptide binding]; other site
383372004531	seryl-tRNA synthetase; Provisional; Region: PRK05431
383372004532	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
383372004533	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
383372004534	dimer interface [polypeptide binding]; other site
383372004535	active site
383372004536	motif 1; other site
383372004537	motif 2; other site
383372004538	motif 3; other site
383372004539	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
383372004540	putative active site [active]
383372004541	nucleotide binding site [chemical binding]; other site
383372004542	nudix motif; other site
383372004543	putative metal binding site [ion binding]; other site
383372004544	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
383372004545	nudix motif; other site
383372004546	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
383372004547	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
383372004548	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
383372004549	Amidohydrolase; Region: Amidohydro_2; pfam04909
383372004550	Phosphotransferase enzyme family; Region: APH; pfam01636
383372004551	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
383372004552	Uncharacterized conserved protein [Function unknown]; Region: COG1543
383372004553	N-terminal catalytic domain of heat stable retaining glycoside hydrolase family 57; Region: GH57N_like; cd01022
383372004554	active site
383372004555	catalytic site [active]
383372004556	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
383372004557	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
383372004558	active site residue [active]
383372004559	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372004560	HAMP domain; Region: HAMP; pfam00672
383372004561	dimerization interface [polypeptide binding]; other site
383372004562	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372004563	dimer interface [polypeptide binding]; other site
383372004564	phosphorylation site [posttranslational modification]
383372004565	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372004566	ATP binding site [chemical binding]; other site
383372004567	G-X-G motif; other site
383372004568	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372004569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372004570	active site
383372004571	phosphorylation site [posttranslational modification]
383372004572	intermolecular recognition site; other site
383372004573	dimerization interface [polypeptide binding]; other site
383372004574	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372004575	DNA binding site [nucleotide binding]
383372004576	Response regulator receiver domain; Region: Response_reg; pfam00072
383372004577	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372004578	PAS domain; Region: PAS_9; pfam13426
383372004579	putative active site [active]
383372004580	heme pocket [chemical binding]; other site
383372004581	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
383372004582	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
383372004583	metal binding site [ion binding]; metal-binding site
383372004584	active site
383372004585	I-site; other site
383372004586	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
383372004587	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
383372004588	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
383372004589	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
383372004590	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
383372004591	Walker A/P-loop; other site
383372004592	ATP binding site [chemical binding]; other site
383372004593	Q-loop/lid; other site
383372004594	ABC transporter signature motif; other site
383372004595	Walker B; other site
383372004596	D-loop; other site
383372004597	H-loop/switch region; other site
383372004598	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
383372004599	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
383372004600	active site
383372004601	tetramer interface [polypeptide binding]; other site
383372004602	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
383372004603	active site
383372004604	DNA polymerase I; Region: pola; TIGR00593
383372004605	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
383372004606	active site
383372004607	metal binding site 1 [ion binding]; metal-binding site
383372004608	putative 5' ssDNA interaction site; other site
383372004609	metal binding site 3; metal-binding site
383372004610	metal binding site 2 [ion binding]; metal-binding site
383372004611	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
383372004612	putative DNA binding site [nucleotide binding]; other site
383372004613	putative metal binding site [ion binding]; other site
383372004614	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
383372004615	active site
383372004616	catalytic site [active]
383372004617	substrate binding site [chemical binding]; other site
383372004618	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
383372004619	active site
383372004620	DNA binding site [nucleotide binding]
383372004621	catalytic site [active]
383372004622	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
383372004623	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
383372004624	Ligand binding site; other site
383372004625	Putative Catalytic site; other site
383372004626	DXD motif; other site
383372004627	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
383372004628	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
383372004629	PemK-like protein; Region: PemK; pfam02452
383372004630	elongation factor P; Validated; Region: PRK00529
383372004631	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
383372004632	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
383372004633	RNA binding site [nucleotide binding]; other site
383372004634	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
383372004635	RNA binding site [nucleotide binding]; other site
383372004636	putative carbohydrate kinase; Provisional; Region: PRK10565
383372004637	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
383372004638	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
383372004639	putative substrate binding site [chemical binding]; other site
383372004640	putative ATP binding site [chemical binding]; other site
383372004641	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372004642	putative active site [active]
383372004643	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
383372004644	SCP-2 sterol transfer family; Region: SCP2; pfam02036
383372004645	FOG: CBS domain [General function prediction only]; Region: COG0517
383372004646	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
383372004647	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
383372004648	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
383372004649	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
383372004650	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
383372004651	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
383372004652	dimer interface [polypeptide binding]; other site
383372004653	ssDNA binding site [nucleotide binding]; other site
383372004654	tetramer (dimer of dimers) interface [polypeptide binding]; other site
383372004655	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
383372004656	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
383372004657	Protein of unknown function (DUF2679); Region: DUF2679; pfam10882
383372004658	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
383372004659	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
383372004660	E3 interaction surface; other site
383372004661	lipoyl attachment site [posttranslational modification]; other site
383372004662	e3 binding domain; Region: E3_binding; pfam02817
383372004663	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
383372004664	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
383372004665	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
383372004666	TPP-binding site [chemical binding]; other site
383372004667	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
383372004668	dimer interface [polypeptide binding]; other site
383372004669	PYR/PP interface [polypeptide binding]; other site
383372004670	TPP binding site [chemical binding]; other site
383372004671	Fatty acid desaturase; Region: FA_desaturase; pfam00487
383372004672	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
383372004673	putative di-iron ligands [ion binding]; other site
383372004674	PUCC protein; Region: PUCC; pfam03209
383372004675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372004676	S-adenosylmethionine binding site [chemical binding]; other site
383372004677	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
383372004678	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
383372004679	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
383372004680	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
383372004681	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
383372004682	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
383372004683	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
383372004684	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
383372004685	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372004686	S-adenosylmethionine binding site [chemical binding]; other site
383372004687	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
383372004688	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
383372004689	diiron binding motif [ion binding]; other site
383372004690	magnesium chelatase subunit H; Provisional; Region: PRK12493
383372004691	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
383372004692	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
383372004693	PUCC protein; Region: PUCC; pfam03209
383372004694	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372004695	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
383372004696	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
383372004697	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
383372004698	active site
383372004699	catalytic site [active]
383372004700	substrate binding site [chemical binding]; other site
383372004701	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
383372004702	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
383372004703	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
383372004704	tartrate dehydrogenase; Region: TTC; TIGR02089
383372004705	Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
383372004706	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
383372004707	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
383372004708	substrate binding site [chemical binding]; other site
383372004709	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
383372004710	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
383372004711	substrate binding site [chemical binding]; other site
383372004712	ligand binding site [chemical binding]; other site
383372004713	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
383372004714	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
383372004715	homodimer interface [polypeptide binding]; other site
383372004716	substrate-cofactor binding pocket; other site
383372004717	catalytic residue [active]
383372004718	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
383372004719	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
383372004720	active site
383372004721	catalytic residues [active]
383372004722	metal binding site [ion binding]; metal-binding site
383372004723	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
383372004724	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
383372004725	Prephenate dehydratase; Region: PDT; pfam00800
383372004726	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
383372004727	putative L-Phe binding site [chemical binding]; other site
383372004728	2-isopropylmalate synthase; Validated; Region: PRK00915
383372004729	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
383372004730	active site
383372004731	catalytic residues [active]
383372004732	metal binding site [ion binding]; metal-binding site
383372004733	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
383372004734	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
383372004735	four helix bundle protein; Region: TIGR02436
383372004736	ketol-acid reductoisomerase; Provisional; Region: PRK05479
383372004737	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
383372004738	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
383372004739	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
383372004740	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
383372004741	putative valine binding site [chemical binding]; other site
383372004742	dimer interface [polypeptide binding]; other site
383372004743	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
383372004744	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
383372004745	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
383372004746	PYR/PP interface [polypeptide binding]; other site
383372004747	dimer interface [polypeptide binding]; other site
383372004748	TPP binding site [chemical binding]; other site
383372004749	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
383372004750	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
383372004751	TPP-binding site [chemical binding]; other site
383372004752	dimer interface [polypeptide binding]; other site
383372004753	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
383372004754	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
383372004755	tetramer interface [polypeptide binding]; other site
383372004756	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372004757	catalytic residue [active]
383372004758	homoserine dehydrogenase; Provisional; Region: PRK06270
383372004759	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
383372004760	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372004761	putative active site [active]
383372004762	S-adenosylmethionine synthetase; Validated; Region: PRK05250
383372004763	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
383372004764	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
383372004765	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
383372004766	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
383372004767	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
383372004768	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
383372004769	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
383372004770	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
383372004771	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372004772	motif II; other site
383372004773	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
383372004774	PAS domain; Region: PAS_9; pfam13426
383372004775	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
383372004776	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
383372004777	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
383372004778	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372004779	homodimer interface [polypeptide binding]; other site
383372004780	catalytic residue [active]
383372004781	Thymidylate synthase complementing protein; Region: Thy1; cl03630
383372004782	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
383372004783	Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481
383372004784	active site
383372004785	catalytic triad [active]
383372004786	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
383372004787	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
383372004788	P loop; other site
383372004789	Nucleotide binding site [chemical binding]; other site
383372004790	DTAP/Switch II; other site
383372004791	Switch I; other site
383372004792	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
383372004793	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
383372004794	Cu(I) binding site [ion binding]; other site
383372004795	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
383372004796	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
383372004797	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
383372004798	Low-spin heme binding site [chemical binding]; other site
383372004799	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
383372004800	D-pathway; other site
383372004801	Putative water exit pathway; other site
383372004802	Binuclear center (active site) [active]
383372004803	K-pathway; other site
383372004804	Putative proton exit pathway; other site
383372004805	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
383372004806	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
383372004807	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
383372004808	non-specific DNA binding site [nucleotide binding]; other site
383372004809	salt bridge; other site
383372004810	sequence-specific DNA binding site [nucleotide binding]; other site
383372004811	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
383372004812	peptide binding site [polypeptide binding]; other site
383372004813	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
383372004814	dimer interface [polypeptide binding]; other site
383372004815	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372004816	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372004817	active site
383372004818	phosphorylation site [posttranslational modification]
383372004819	intermolecular recognition site; other site
383372004820	dimerization interface [polypeptide binding]; other site
383372004821	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372004822	DNA binding residues [nucleotide binding]
383372004823	dimerization interface [polypeptide binding]; other site
383372004824	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
383372004825	Histidine kinase; Region: HisKA_3; pfam07730
383372004826	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372004827	ATP binding site [chemical binding]; other site
383372004828	Mg2+ binding site [ion binding]; other site
383372004829	G-X-G motif; other site
383372004830	V4R domain; Region: V4R; cl15268
383372004831	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
383372004832	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372004833	FeS/SAM binding site; other site
383372004834	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
383372004835	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
383372004836	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372004837	FeS/SAM binding site; other site
383372004838	phytoene desaturase; Region: crtI_fam; TIGR02734
383372004839	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
383372004840	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
383372004841	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
383372004842	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
383372004843	putative active site [active]
383372004844	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
383372004845	L-lactate permease; Region: Lactate_perm; cl00701
383372004846	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
383372004847	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
383372004848	ABC-ATPase subunit  interface; other site
383372004849	dimer interface [polypeptide binding]; other site
383372004850	putative PBP binding regions; other site
383372004851	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
383372004852	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
383372004853	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
383372004854	intersubunit interface [polypeptide binding]; other site
383372004855	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
383372004856	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
383372004857	Protein kinase domain; Region: Pkinase; pfam00069
383372004858	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
383372004859	active site
383372004860	ATP binding site [chemical binding]; other site
383372004861	substrate binding site [chemical binding]; other site
383372004862	Bacterial SH3 domain; Region: SH3_3; pfam08239
383372004863	NAD-dependent deacetylase; Provisional; Region: PRK00481
383372004864	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
383372004865	NAD+ binding site [chemical binding]; other site
383372004866	substrate binding site [chemical binding]; other site
383372004867	Zn binding site [ion binding]; other site
383372004868	NAD-dependent deacetylase; Provisional; Region: PRK00481
383372004869	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
383372004870	NAD+ binding site [chemical binding]; other site
383372004871	substrate binding site [chemical binding]; other site
383372004872	Zn binding site [ion binding]; other site
383372004873	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
383372004874	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
383372004875	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
383372004876	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
383372004877	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
383372004878	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
383372004879	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
383372004880	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
383372004881	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
383372004882	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
383372004883	G-loop; other site
383372004884	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
383372004885	DNA binding site [nucleotide binding]
383372004886	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
383372004887	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563
383372004888	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
383372004889	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
383372004890	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
383372004891	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
383372004892	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
383372004893	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
383372004894	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
383372004895	RPB10 interaction site [polypeptide binding]; other site
383372004896	RPB1 interaction site [polypeptide binding]; other site
383372004897	RPB11 interaction site [polypeptide binding]; other site
383372004898	RPB3 interaction site [polypeptide binding]; other site
383372004899	RPB12 interaction site [polypeptide binding]; other site
383372004900	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
383372004901	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
383372004902	Protein of unknown function (DUF499); Region: DUF499; pfam04465
383372004903	Divergent AAA domain; Region: AAA_4; pfam04326
383372004904	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
383372004905	AAA domain; Region: AAA_23; pfam13476
383372004906	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372004907	Walker A/P-loop; other site
383372004908	ATP binding site [chemical binding]; other site
383372004909	AAA domain; Region: AAA_21; pfam13304
383372004910	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372004911	ABC transporter signature motif; other site
383372004912	Walker B; other site
383372004913	D-loop; other site
383372004914	H-loop/switch region; other site
383372004915	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
383372004916	Methyltransferase domain; Region: Methyltransf_26; pfam13659
383372004917	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
383372004918	putative active site [active]
383372004919	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
383372004920	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
383372004921	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
383372004922	ATP binding site [chemical binding]; other site
383372004923	putative Mg++ binding site [ion binding]; other site
383372004924	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
383372004925	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
383372004926	nucleotide binding region [chemical binding]; other site
383372004927	ATP-binding site [chemical binding]; other site
383372004928	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
383372004929	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
383372004930	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
383372004931	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
383372004932	nudix motif; other site
383372004933	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
383372004934	NAD(P) binding pocket [chemical binding]; other site
383372004935	GTP-binding protein LepA; Provisional; Region: PRK05433
383372004936	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
383372004937	G1 box; other site
383372004938	putative GEF interaction site [polypeptide binding]; other site
383372004939	GTP/Mg2+ binding site [chemical binding]; other site
383372004940	Switch I region; other site
383372004941	G2 box; other site
383372004942	G3 box; other site
383372004943	Switch II region; other site
383372004944	G4 box; other site
383372004945	G5 box; other site
383372004946	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
383372004947	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
383372004948	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
383372004949	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
383372004950	SurA N-terminal domain; Region: SurA_N; pfam09312
383372004951	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
383372004952	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
383372004953	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
383372004954	active site
383372004955	homodimer interface [polypeptide binding]; other site
383372004956	SAM binding site [chemical binding]; other site
383372004957	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
383372004958	homodimer interface [polypeptide binding]; other site
383372004959	metal binding site [ion binding]; metal-binding site
383372004960	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
383372004961	homodimer interface [polypeptide binding]; other site
383372004962	active site
383372004963	putative chemical substrate binding site [chemical binding]; other site
383372004964	metal binding site [ion binding]; metal-binding site
383372004965	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
383372004966	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
383372004967	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
383372004968	dimer interface [polypeptide binding]; other site
383372004969	active site residues [active]
383372004970	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
383372004971	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
383372004972	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
383372004973	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372004974	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
383372004975	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372004976	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
383372004977	AIR carboxylase; Region: AIRC; smart01001
383372004978	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
383372004979	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
383372004980	Ligand Binding Site [chemical binding]; other site
383372004981	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
383372004982	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
383372004983	ligand binding site [chemical binding]; other site
383372004984	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
383372004985	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
383372004986	TM-ABC transporter signature motif; other site
383372004987	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
383372004988	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
383372004989	TM-ABC transporter signature motif; other site
383372004990	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
383372004991	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
383372004992	Walker A/P-loop; other site
383372004993	ATP binding site [chemical binding]; other site
383372004994	Q-loop/lid; other site
383372004995	ABC transporter signature motif; other site
383372004996	Walker B; other site
383372004997	D-loop; other site
383372004998	H-loop/switch region; other site
383372004999	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
383372005000	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
383372005001	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
383372005002	active site
383372005003	Protein of unknown function (DUF433); Region: DUF433; pfam04255
383372005004	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
383372005005	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
383372005006	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
383372005007	active site
383372005008	Divergent AAA domain; Region: AAA_4; pfam04326
383372005009	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
383372005010	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372005011	active site
383372005012	motif I; other site
383372005013	motif II; other site
383372005014	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372005015	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
383372005016	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
383372005017	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
383372005018	active site
383372005019	HIGH motif; other site
383372005020	nucleotide binding site [chemical binding]; other site
383372005021	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
383372005022	KMSK motif region; other site
383372005023	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
383372005024	tRNA binding surface [nucleotide binding]; other site
383372005025	anticodon binding site; other site
383372005026	Cache domain; Region: Cache_1; pfam02743
383372005027	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372005028	dimerization interface [polypeptide binding]; other site
383372005029	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372005030	GAF domain; Region: GAF_3; pfam13492
383372005031	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372005032	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372005033	dimer interface [polypeptide binding]; other site
383372005034	phosphorylation site [posttranslational modification]
383372005035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372005036	ATP binding site [chemical binding]; other site
383372005037	Mg2+ binding site [ion binding]; other site
383372005038	G-X-G motif; other site
383372005039	Response regulator receiver domain; Region: Response_reg; pfam00072
383372005040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372005041	active site
383372005042	phosphorylation site [posttranslational modification]
383372005043	intermolecular recognition site; other site
383372005044	dimerization interface [polypeptide binding]; other site
383372005045	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372005046	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372005047	dimer interface [polypeptide binding]; other site
383372005048	phosphorylation site [posttranslational modification]
383372005049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372005050	ATP binding site [chemical binding]; other site
383372005051	Mg2+ binding site [ion binding]; other site
383372005052	G-X-G motif; other site
383372005053	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
383372005054	GTP-binding protein YchF; Reviewed; Region: PRK09601
383372005055	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
383372005056	G1 box; other site
383372005057	GTP/Mg2+ binding site [chemical binding]; other site
383372005058	G2 box; other site
383372005059	Switch I region; other site
383372005060	G3 box; other site
383372005061	Switch II region; other site
383372005062	G4 box; other site
383372005063	G5 box; other site
383372005064	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
383372005065	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
383372005066	metal binding site 2 [ion binding]; metal-binding site
383372005067	putative DNA binding helix; other site
383372005068	metal binding site 1 [ion binding]; metal-binding site
383372005069	dimer interface [polypeptide binding]; other site
383372005070	structural Zn2+ binding site [ion binding]; other site
383372005071	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
383372005072	putative active site [active]
383372005073	putative CoA binding site [chemical binding]; other site
383372005074	nudix motif; other site
383372005075	metal binding site [ion binding]; metal-binding site
383372005076	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
383372005077	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
383372005078	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
383372005079	active site
383372005080	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
383372005081	purine nucleoside phosphorylase; Provisional; Region: PRK08202
383372005082	Bacterial PH domain; Region: DUF304; pfam03703
383372005083	Short C-terminal domain; Region: SHOCT; pfam09851
383372005084	Recombination protein O N terminal; Region: RecO_N; pfam11967
383372005085	DNA repair protein RecO; Region: reco; TIGR00613
383372005086	Recombination protein O C terminal; Region: RecO_C; pfam02565
383372005087	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
383372005088	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
383372005089	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
383372005090	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372005091	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372005092	DNA binding residues [nucleotide binding]
383372005093	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
383372005094	Thioredoxin; Region: Thioredoxin_4; pfam13462
383372005095	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372005096	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
383372005097	active site
383372005098	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
383372005099	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
383372005100	RimM N-terminal domain; Region: RimM; pfam01782
383372005101	PRC-barrel domain; Region: PRC; pfam05239
383372005102	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
383372005103	KH domain; Region: KH_4; pfam13083
383372005104	G-X-X-G motif; other site
383372005105	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
383372005106	signal recognition particle protein; Provisional; Region: PRK10867
383372005107	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
383372005108	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
383372005109	P loop; other site
383372005110	GTP binding site [chemical binding]; other site
383372005111	Signal peptide binding domain; Region: SRP_SPB; pfam02978
383372005112	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
383372005113	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
383372005114	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
383372005115	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
383372005116	Walker A/P-loop; other site
383372005117	ATP binding site [chemical binding]; other site
383372005118	Q-loop/lid; other site
383372005119	ABC transporter signature motif; other site
383372005120	Walker B; other site
383372005121	D-loop; other site
383372005122	H-loop/switch region; other site
383372005123	rod shape-determining protein MreB; Provisional; Region: PRK13927
383372005124	MreB and similar proteins; Region: MreB_like; cd10225
383372005125	nucleotide binding site [chemical binding]; other site
383372005126	Mg binding site [ion binding]; other site
383372005127	putative protofilament interaction site [polypeptide binding]; other site
383372005128	RodZ interaction site [polypeptide binding]; other site
383372005129	rod shape-determining protein MreC; Provisional; Region: PRK13922
383372005130	rod shape-determining protein MreC; Region: MreC; pfam04085
383372005131	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
383372005132	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
383372005133	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
383372005134	oligomeric interface; other site
383372005135	putative active site [active]
383372005136	homodimer interface [polypeptide binding]; other site
383372005137	Protein of unknown function DUF104; Region: DUF104; cl11530
383372005138	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
383372005139	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
383372005140	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
383372005141	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
383372005142	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
383372005143	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
383372005144	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
383372005145	ATP binding site [chemical binding]; other site
383372005146	Walker A motif; other site
383372005147	hexamer interface [polypeptide binding]; other site
383372005148	Walker B motif; other site
383372005149	Response regulator receiver domain; Region: Response_reg; pfam00072
383372005150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372005151	active site
383372005152	phosphorylation site [posttranslational modification]
383372005153	intermolecular recognition site; other site
383372005154	dimerization interface [polypeptide binding]; other site
383372005155	AAA domain; Region: AAA_31; pfam13614
383372005156	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
383372005157	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
383372005158	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
383372005159	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372005160	metal ion-dependent adhesion site (MIDAS); other site
383372005161	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
383372005162	TadE-like protein; Region: TadE; pfam07811
383372005163	DNA topoisomerase I; Validated; Region: PRK06599
383372005164	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
383372005165	active site
383372005166	interdomain interaction site; other site
383372005167	putative metal-binding site [ion binding]; other site
383372005168	nucleotide binding site [chemical binding]; other site
383372005169	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
383372005170	domain I; other site
383372005171	DNA binding groove [nucleotide binding]
383372005172	phosphate binding site [ion binding]; other site
383372005173	domain II; other site
383372005174	domain III; other site
383372005175	nucleotide binding site [chemical binding]; other site
383372005176	catalytic site [active]
383372005177	domain IV; other site
383372005178	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
383372005179	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
383372005180	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
383372005181	SLBB domain; Region: SLBB; pfam10531
383372005182	comEA protein; Region: comE; TIGR01259
383372005183	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
383372005184	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
383372005185	domain interfaces; other site
383372005186	active site
383372005187	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
383372005188	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
383372005189	substrate binding pocket [chemical binding]; other site
383372005190	membrane-bound complex binding site; other site
383372005191	hinge residues; other site
383372005192	hypothetical protein; Provisional; Region: PRK08201
383372005193	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
383372005194	metal binding site [ion binding]; metal-binding site
383372005195	putative dimer interface [polypeptide binding]; other site
383372005196	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
383372005197	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
383372005198	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
383372005199	NADP binding site [chemical binding]; other site
383372005200	active site
383372005201	putative substrate binding site [chemical binding]; other site
383372005202	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
383372005203	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372005204	Probable Catalytic site; other site
383372005205	metal-binding site
383372005206	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
383372005207	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
383372005208	Ligand binding site; other site
383372005209	Ligand binding site; other site
383372005210	Ligand binding site; other site
383372005211	Putative Catalytic site; other site
383372005212	DXD motif; other site
383372005213	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372005214	putative active site [active]
383372005215	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372005216	putative active site [active]
383372005217	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
383372005218	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
383372005219	active site
383372005220	catalytic tetrad [active]
383372005221	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
383372005222	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
383372005223	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
383372005224	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
383372005225	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
383372005226	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
383372005227	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
383372005228	hexamer interface [polypeptide binding]; other site
383372005229	Walker B motif; other site
383372005230	Type II/IV secretion system protein; Region: T2SE; pfam00437
383372005231	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
383372005232	ATP binding site [chemical binding]; other site
383372005233	Walker A motif; other site
383372005234	hexamer interface [polypeptide binding]; other site
383372005235	Walker B motif; other site
383372005236	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372005237	metal ion-dependent adhesion site (MIDAS); other site
383372005238	Filamin/ABP280 repeat; Region: Filamin; pfam00630
383372005239	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
383372005240	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
383372005241	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372005242	active site
383372005243	NTP binding site [chemical binding]; other site
383372005244	metal binding triad [ion binding]; metal-binding site
383372005245	antibiotic binding site [chemical binding]; other site
383372005246	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
383372005247	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
383372005248	ABC-ATPase subunit  interface; other site
383372005249	dimer interface [polypeptide binding]; other site
383372005250	putative PBP binding regions; other site
383372005251	Transcriptional regulators [Transcription]; Region: MarR; COG1846
383372005252	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
383372005253	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
383372005254	ABC-ATPase subunit  interface; other site
383372005255	dimer interface [polypeptide binding]; other site
383372005256	putative PBP binding regions; other site
383372005257	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
383372005258	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
383372005259	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
383372005260	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
383372005261	intersubunit interface [polypeptide binding]; other site
383372005262	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
383372005263	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
383372005264	active site
383372005265	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
383372005266	putative active site [active]
383372005267	catalytic residue [active]
383372005268	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
383372005269	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
383372005270	G1 box; other site
383372005271	GTP/Mg2+ binding site [chemical binding]; other site
383372005272	G2 box; other site
383372005273	Switch I region; other site
383372005274	G3 box; other site
383372005275	Switch II region; other site
383372005276	G4 box; other site
383372005277	G5 box; other site
383372005278	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
383372005279	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
383372005280	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
383372005281	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
383372005282	Ligand Binding Site [chemical binding]; other site
383372005283	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
383372005284	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
383372005285	FAD binding domain; Region: FAD_binding_4; pfam01565
383372005286	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
383372005287	Cysteine-rich domain; Region: CCG; pfam02754
383372005288	Cysteine-rich domain; Region: CCG; pfam02754
383372005289	Helix-turn-helix domain; Region: HTH_17; pfam12728
383372005290	Sensory domain found in PocR; Region: PocR; pfam10114
383372005291	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
383372005292	GMP synthase; Reviewed; Region: guaA; PRK00074
383372005293	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
383372005294	AMP/PPi binding site [chemical binding]; other site
383372005295	candidate oxyanion hole; other site
383372005296	catalytic triad [active]
383372005297	potential glutamine specificity residues [chemical binding]; other site
383372005298	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
383372005299	ATP Binding subdomain [chemical binding]; other site
383372005300	Ligand Binding sites [chemical binding]; other site
383372005301	Dimerization subdomain; other site
383372005302	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
383372005303	catalytic core [active]
383372005304	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
383372005305	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
383372005306	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
383372005307	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
383372005308	active site
383372005309	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
383372005310	Divergent AAA domain; Region: AAA_4; pfam04326
383372005311	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
383372005312	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
383372005313	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
383372005314	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502
383372005315	active site
383372005316	catalytic triad [active]
383372005317	oxyanion hole [active]
383372005318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
383372005319	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
383372005320	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
383372005321	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
383372005322	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
383372005323	protein binding site [polypeptide binding]; other site
383372005324	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
383372005325	TIGR01777 family protein; Region: yfcH
383372005326	putative NAD(P) binding site [chemical binding]; other site
383372005327	putative active site [active]
383372005328	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
383372005329	active site lid residues [active]
383372005330	substrate binding pocket [chemical binding]; other site
383372005331	catalytic residues [active]
383372005332	substrate-Mg2+ binding site; other site
383372005333	aspartate-rich region 1; other site
383372005334	aspartate-rich region 2; other site
383372005335	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
383372005336	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
383372005337	DNA binding residues [nucleotide binding]
383372005338	B12 binding domain; Region: B12-binding_2; pfam02607
383372005339	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
383372005340	B12 binding domain; Region: B12-binding; pfam02310
383372005341	B12 binding site [chemical binding]; other site
383372005342	VPS10 domain; Region: VPS10; smart00602
383372005343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
383372005344	Methyltransferase domain; Region: Methyltransf_31; pfam13847
383372005345	Domain of unknown function (DUF309); Region: DUF309; pfam03745
383372005346	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
383372005347	active site residue [active]
383372005348	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
383372005349	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
383372005350	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372005351	FeS/SAM binding site; other site
383372005352	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
383372005353	antiporter inner membrane protein; Provisional; Region: PRK11670
383372005354	Domain of unknown function DUF59; Region: DUF59; pfam01883
383372005355	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
383372005356	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
383372005357	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
383372005358	Walker A/P-loop; other site
383372005359	ATP binding site [chemical binding]; other site
383372005360	Q-loop/lid; other site
383372005361	ABC transporter signature motif; other site
383372005362	Walker B; other site
383372005363	D-loop; other site
383372005364	H-loop/switch region; other site
383372005365	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
383372005366	Ligand Binding Site [chemical binding]; other site
383372005367	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
383372005368	Ligand Binding Site [chemical binding]; other site
383372005369	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
383372005370	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
383372005371	Walker A/P-loop; other site
383372005372	ATP binding site [chemical binding]; other site
383372005373	Q-loop/lid; other site
383372005374	ABC transporter signature motif; other site
383372005375	Walker B; other site
383372005376	D-loop; other site
383372005377	H-loop/switch region; other site
383372005378	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
383372005379	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
383372005380	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
383372005381	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
383372005382	E3 interaction surface; other site
383372005383	lipoyl attachment site [posttranslational modification]; other site
383372005384	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
383372005385	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
383372005386	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
383372005387	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
383372005388	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
383372005389	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
383372005390	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
383372005391	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
383372005392	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
383372005393	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509
383372005394	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659
383372005395	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
383372005396	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
383372005397	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
383372005398	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
383372005399	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
383372005400	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
383372005401	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
383372005402	acyl-activating enzyme (AAE) consensus motif; other site
383372005403	putative AMP binding site [chemical binding]; other site
383372005404	putative active site [active]
383372005405	putative CoA binding site [chemical binding]; other site
383372005406	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
383372005407	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
383372005408	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
383372005409	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
383372005410	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
383372005411	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
383372005412	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
383372005413	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
383372005414	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
383372005415	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
383372005416	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
383372005417	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
383372005418	TrkA-N domain; Region: TrkA_N; pfam02254
383372005419	TrkA-C domain; Region: TrkA_C; pfam02080
383372005420	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
383372005421	AsnC family; Region: AsnC_trans_reg; pfam01037
383372005422	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
383372005423	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
383372005424	acyl-activating enzyme (AAE) consensus motif; other site
383372005425	putative AMP binding site [chemical binding]; other site
383372005426	putative active site [active]
383372005427	putative CoA binding site [chemical binding]; other site
383372005428	CpXC protein; Region: CpXC; pfam14353
383372005429	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
383372005430	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
383372005431	active site
383372005432	metal binding site [ion binding]; metal-binding site
383372005433	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372005434	GAF domain; Region: GAF; cl17456
383372005435	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
383372005436	dimer interface [polypeptide binding]; other site
383372005437	phosphorylation site [posttranslational modification]
383372005438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372005439	ATP binding site [chemical binding]; other site
383372005440	Mg2+ binding site [ion binding]; other site
383372005441	G-X-G motif; other site
383372005442	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
383372005443	Dodecin; Region: Dodecin; pfam07311
383372005444	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
383372005445	putative deacylase active site [active]
383372005446	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
383372005447	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
383372005448	active site
383372005449	HIGH motif; other site
383372005450	dimer interface [polypeptide binding]; other site
383372005451	KMSKS motif; other site
383372005452	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
383372005453	RNA binding surface [nucleotide binding]; other site
383372005454	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
383372005455	Peptidase family M50; Region: Peptidase_M50; pfam02163
383372005456	active site
383372005457	putative substrate binding region [chemical binding]; other site
383372005458	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
383372005459	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
383372005460	ligand binding site [chemical binding]; other site
383372005461	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
383372005462	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
383372005463	ligand binding site [chemical binding]; other site
383372005464	flexible hinge region; other site
383372005465	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
383372005466	classical (c) SDRs; Region: SDR_c; cd05233
383372005467	NAD(P) binding site [chemical binding]; other site
383372005468	active site
383372005469	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
383372005470	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
383372005471	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
383372005472	dimerization interface [polypeptide binding]; other site
383372005473	ATP binding site [chemical binding]; other site
383372005474	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
383372005475	dimerization interface [polypeptide binding]; other site
383372005476	ATP binding site [chemical binding]; other site
383372005477	Protein of unknown function (DUF1444); Region: DUF1444; pfam07285
383372005478	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
383372005479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372005480	S-adenosylmethionine binding site [chemical binding]; other site
383372005481	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
383372005482	Putative esterase; Region: Esterase; pfam00756
383372005483	ATP-grasp domain; Region: ATP-grasp_4; cl17255
383372005484	Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; pfam14403
383372005485	carboxylate-amine ligase; Provisional; Region: PRK13515
383372005486	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
383372005487	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
383372005488	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
383372005489	dimer interface [polypeptide binding]; other site
383372005490	active site
383372005491	CoA binding pocket [chemical binding]; other site
383372005492	Ribosomal L32p protein family; Region: Ribosomal_L32p; pfam01783
383372005493	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
383372005494	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
383372005495	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
383372005496	active site
383372005497	(T/H)XGH motif; other site
383372005498	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
383372005499	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372005500	S-adenosylmethionine binding site [chemical binding]; other site
383372005501	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
383372005502	DNA methylase; Region: N6_N4_Mtase; pfam01555
383372005503	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
383372005504	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
383372005505	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
383372005506	catalytic residue [active]
383372005507	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
383372005508	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
383372005509	active site
383372005510	metal binding site [ion binding]; metal-binding site
383372005511	Sporulation and spore germination; Region: Germane; pfam10646
383372005512	Sporulation and spore germination; Region: Germane; pfam10646
383372005513	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
383372005514	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
383372005515	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
383372005516	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
383372005517	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
383372005518	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
383372005519	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
383372005520	Protease prsW family; Region: PrsW-protease; pfam13367
383372005521	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
383372005522	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
383372005523	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
383372005524	putative active site; other site
383372005525	catalytic triad [active]
383372005526	putative dimer interface [polypeptide binding]; other site
383372005527	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
383372005528	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
383372005529	Integral membrane protein DUF92; Region: DUF92; pfam01940
383372005530	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
383372005531	hydrophobic ligand binding site; other site
383372005532	Aspartyl protease; Region: Asp_protease_2; pfam13650
383372005533	inhibitor binding site; inhibition site
383372005534	catalytic motif [active]
383372005535	Catalytic residue [active]
383372005536	Active site flap [active]
383372005537	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
383372005538	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
383372005539	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
383372005540	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
383372005541	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
383372005542	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
383372005543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372005544	Walker A/P-loop; other site
383372005545	ATP binding site [chemical binding]; other site
383372005546	Q-loop/lid; other site
383372005547	ABC transporter signature motif; other site
383372005548	Walker B; other site
383372005549	D-loop; other site
383372005550	H-loop/switch region; other site
383372005551	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
383372005552	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372005553	putative active site [active]
383372005554	TPR repeat; Region: TPR_11; pfam13414
383372005555	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372005556	binding surface
383372005557	TPR motif; other site
383372005558	TPR repeat; Region: TPR_11; pfam13414
383372005559	TPR repeat; Region: TPR_11; pfam13414
383372005560	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372005561	binding surface
383372005562	TPR motif; other site
383372005563	TPR repeat; Region: TPR_11; pfam13414
383372005564	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372005565	binding surface
383372005566	TPR motif; other site
383372005567	TPR repeat; Region: TPR_11; pfam13414
383372005568	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
383372005569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372005570	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
383372005571	putative substrate translocation pore; other site
383372005572	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
383372005573	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372005574	active site
383372005575	motif I; other site
383372005576	motif II; other site
383372005577	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372005578	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372005579	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
383372005580	putative ADP-binding pocket [chemical binding]; other site
383372005581	hypothetical protein; Provisional; Region: PRK06446
383372005582	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
383372005583	metal binding site [ion binding]; metal-binding site
383372005584	dimer interface [polypeptide binding]; other site
383372005585	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
383372005586	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
383372005587	active site
383372005588	Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Ade5; cd01416
383372005589	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
383372005590	ATP binding site [chemical binding]; other site
383372005591	active site
383372005592	substrate binding site [chemical binding]; other site
383372005593	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
383372005594	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
383372005595	dimerization interface [polypeptide binding]; other site
383372005596	putative ATP binding site [chemical binding]; other site
383372005597	Acylphosphatase; Region: Acylphosphatase; pfam00708
383372005598	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
383372005599	HypF finger; Region: zf-HYPF; pfam07503
383372005600	HypF finger; Region: zf-HYPF; pfam07503
383372005601	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
383372005602	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
383372005603	active site
383372005604	substrate binding pocket [chemical binding]; other site
383372005605	dimer interface [polypeptide binding]; other site
383372005606	Transcriptional regulators [Transcription]; Region: PurR; COG1609
383372005607	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
383372005608	DNA binding site [nucleotide binding]
383372005609	domain linker motif; other site
383372005610	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
383372005611	putative dimerization interface [polypeptide binding]; other site
383372005612	putative ligand binding site [chemical binding]; other site
383372005613	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
383372005614	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
383372005615	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
383372005616	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
383372005617	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
383372005618	Domain of unknown function (DUF427); Region: DUF427; pfam04248
383372005619	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
383372005620	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372005621	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372005622	putative active site [active]
383372005623	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
383372005624	FtsX-like permease family; Region: FtsX; pfam02687
383372005625	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
383372005626	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
383372005627	FtsX-like permease family; Region: FtsX; pfam02687
383372005628	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
383372005629	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
383372005630	active site
383372005631	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
383372005632	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
383372005633	dimer interface [polypeptide binding]; other site
383372005634	putative functional site; other site
383372005635	putative MPT binding site; other site
383372005636	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
383372005637	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
383372005638	dimer interface [polypeptide binding]; other site
383372005639	putative functional site; other site
383372005640	putative MPT binding site; other site
383372005641	PBP superfamily domain; Region: PBP_like; pfam12727
383372005642	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
383372005643	MoaE interaction surface [polypeptide binding]; other site
383372005644	MoeB interaction surface [polypeptide binding]; other site
383372005645	thiocarboxylated glycine; other site
383372005646	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
383372005647	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
383372005648	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
383372005649	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
383372005650	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372005651	putative active site [active]
383372005652	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
383372005653	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805
383372005654	N- and C-terminal domain interface [polypeptide binding]; other site
383372005655	active site
383372005656	MgATP binding site [chemical binding]; other site
383372005657	catalytic site [active]
383372005658	metal binding site [ion binding]; metal-binding site
383372005659	xylulose binding site [chemical binding]; other site
383372005660	putative homodimer interface [polypeptide binding]; other site
383372005661	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
383372005662	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
383372005663	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
383372005664	catalytic residue [active]
383372005665	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
383372005666	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372005667	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372005668	active site
383372005669	ATP binding site [chemical binding]; other site
383372005670	substrate binding site [chemical binding]; other site
383372005671	activation loop (A-loop); other site
383372005672	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
383372005673	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
383372005674	Putative glucoamylase; Region: Glycoamylase; pfam10091
383372005675	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
383372005676	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
383372005677	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
383372005678	Putative glucoamylase; Region: Glycoamylase; pfam10091
383372005679	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
383372005680	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
383372005681	6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478
383372005682	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
383372005683	active site
383372005684	ADP/pyrophosphate binding site [chemical binding]; other site
383372005685	dimerization interface [polypeptide binding]; other site
383372005686	allosteric effector site; other site
383372005687	fructose-1,6-bisphosphate binding site; other site
383372005688	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
383372005689	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
383372005690	putative substrate-binding site; other site
383372005691	nickel binding site [ion binding]; other site
383372005692	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
383372005693	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
383372005694	active site
383372005695	metal binding site [ion binding]; metal-binding site
383372005696	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
383372005697	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
383372005698	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
383372005699	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372005700	dimer interface [polypeptide binding]; other site
383372005701	conserved gate region; other site
383372005702	putative PBP binding loops; other site
383372005703	ABC-ATPase subunit interface; other site
383372005704	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
383372005705	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372005706	dimer interface [polypeptide binding]; other site
383372005707	conserved gate region; other site
383372005708	putative PBP binding loops; other site
383372005709	ABC-ATPase subunit interface; other site
383372005710	Family description; Region: VCBS; pfam13517
383372005711	Family description; Region: VCBS; pfam13517
383372005712	Family description; Region: VCBS; pfam13517
383372005713	Family description; Region: VCBS; pfam13517
383372005714	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
383372005715	alpha-galactosidase; Provisional; Region: PRK15076
383372005716	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
383372005717	NAD binding site [chemical binding]; other site
383372005718	sugar binding site [chemical binding]; other site
383372005719	divalent metal binding site [ion binding]; other site
383372005720	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
383372005721	dimer interface [polypeptide binding]; other site
383372005722	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
383372005723	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
383372005724	dimer interface [polypeptide binding]; other site
383372005725	active site
383372005726	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
383372005727	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
383372005728	dimer interface [polypeptide binding]; other site
383372005729	active site
383372005730	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
383372005731	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
383372005732	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
383372005733	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
383372005734	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
383372005735	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
383372005736	substrate binding site [chemical binding]; other site
383372005737	oxyanion hole (OAH) forming residues; other site
383372005738	trimer interface [polypeptide binding]; other site
383372005739	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
383372005740	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
383372005741	active site
383372005742	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
383372005743	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
383372005744	active site
383372005745	SCP-2 sterol transfer family; Region: SCP2; pfam02036
383372005746	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
383372005747	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
383372005748	dimerization interface [polypeptide binding]; other site
383372005749	ligand binding site [chemical binding]; other site
383372005750	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
383372005751	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
383372005752	TM-ABC transporter signature motif; other site
383372005753	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
383372005754	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
383372005755	TM-ABC transporter signature motif; other site
383372005756	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
383372005757	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
383372005758	Walker A/P-loop; other site
383372005759	ATP binding site [chemical binding]; other site
383372005760	Q-loop/lid; other site
383372005761	ABC transporter signature motif; other site
383372005762	Walker B; other site
383372005763	D-loop; other site
383372005764	H-loop/switch region; other site
383372005765	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
383372005766	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
383372005767	Walker A/P-loop; other site
383372005768	ATP binding site [chemical binding]; other site
383372005769	Q-loop/lid; other site
383372005770	ABC transporter signature motif; other site
383372005771	Walker B; other site
383372005772	D-loop; other site
383372005773	H-loop/switch region; other site
383372005774	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
383372005775	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
383372005776	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
383372005777	alanine racemase; Reviewed; Region: alr; PRK00053
383372005778	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
383372005779	active site
383372005780	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
383372005781	dimer interface [polypeptide binding]; other site
383372005782	substrate binding site [chemical binding]; other site
383372005783	catalytic residues [active]
383372005784	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
383372005785	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
383372005786	active site
383372005787	glutamine synthetase, type I; Region: GlnA; TIGR00653
383372005788	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
383372005789	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
383372005790	ammonium transporter; Region: amt; TIGR00836
383372005791	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
383372005792	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
383372005793	active site
383372005794	dimer interface [polypeptide binding]; other site
383372005795	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
383372005796	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
383372005797	active site
383372005798	FMN binding site [chemical binding]; other site
383372005799	substrate binding site [chemical binding]; other site
383372005800	3Fe-4S cluster binding site [ion binding]; other site
383372005801	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
383372005802	domain interface; other site
383372005803	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
383372005804	DNA binding residues [nucleotide binding]
383372005805	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
383372005806	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372005807	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372005808	DNA binding residues [nucleotide binding]
383372005809	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
383372005810	DNA binding residues [nucleotide binding]
383372005811	HEPN domain; Region: HEPN; pfam05168
383372005812	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372005813	active site
383372005814	NTP binding site [chemical binding]; other site
383372005815	metal binding triad [ion binding]; metal-binding site
383372005816	antibiotic binding site [chemical binding]; other site
383372005817	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372005818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372005819	active site
383372005820	phosphorylation site [posttranslational modification]
383372005821	intermolecular recognition site; other site
383372005822	dimerization interface [polypeptide binding]; other site
383372005823	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372005824	DNA binding residues [nucleotide binding]
383372005825	dimerization interface [polypeptide binding]; other site
383372005826	Domain of unknown function DUF87; Region: DUF87; pfam01935
383372005827	AAA-like domain; Region: AAA_10; pfam12846
383372005828	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
383372005829	beta-galactosidase; Region: BGL; TIGR03356
383372005830	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
383372005831	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372005832	S-adenosylmethionine binding site [chemical binding]; other site
383372005833	Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain.  TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929
383372005834	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
383372005835	FMN binding site [chemical binding]; other site
383372005836	active site
383372005837	homodimer interface [polypeptide binding]; other site
383372005838	putative catalytic residue [active]
383372005839	4Fe-4S cluster binding site [ion binding]; other site
383372005840	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
383372005841	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
383372005842	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372005843	TPR motif; other site
383372005844	binding surface
383372005845	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372005846	DNA binding residues [nucleotide binding]
383372005847	dimerization interface [polypeptide binding]; other site
383372005848	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
383372005849	active site residue [active]
383372005850	ICEA Protein; Region: ICEA; pfam05315
383372005851	DNA methylase; Region: N6_N4_Mtase; pfam01555
383372005852	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
383372005853	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372005854	S-adenosylmethionine binding site [chemical binding]; other site
383372005855	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
383372005856	homotrimer interaction site [polypeptide binding]; other site
383372005857	putative active site [active]
383372005858	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
383372005859	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372005860	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
383372005861	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
383372005862	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
383372005863	Protein of unknown function DUF86; Region: DUF86; pfam01934
383372005864	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
383372005865	TPP-binding site [chemical binding]; other site
383372005866	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
383372005867	dimer interface [polypeptide binding]; other site
383372005868	PYR/PP interface [polypeptide binding]; other site
383372005869	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
383372005870	TPP binding site [chemical binding]; other site
383372005871	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
383372005872	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
383372005873	substrate binding site [chemical binding]; other site
383372005874	active site
383372005875	catalytic residues [active]
383372005876	heterodimer interface [polypeptide binding]; other site
383372005877	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372005878	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372005879	Probable Catalytic site; other site
383372005880	metal-binding site
383372005881	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
383372005882	Bacterial sugar transferase; Region: Bac_transf; pfam02397
383372005883	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
383372005884	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
383372005885	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372005886	putative active site [active]
383372005887	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372005888	putative active site [active]
383372005889	Predicted esterase [General function prediction only]; Region: COG0400
383372005890	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
383372005891	HEPN domain; Region: HEPN; pfam05168
383372005892	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
383372005893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372005894	putative substrate translocation pore; other site
383372005895	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
383372005896	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
383372005897	Coenzyme A binding pocket [chemical binding]; other site
383372005898	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
383372005899	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
383372005900	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
383372005901	gating phenylalanine in ion channel; other site
383372005902	Predicted permease [General function prediction only]; Region: COG2985
383372005903	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
383372005904	TrkA-C domain; Region: TrkA_C; pfam02080
383372005905	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
383372005906	Response regulator receiver domain; Region: Response_reg; pfam00072
383372005907	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372005908	active site
383372005909	phosphorylation site [posttranslational modification]
383372005910	intermolecular recognition site; other site
383372005911	dimerization interface [polypeptide binding]; other site
383372005912	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
383372005913	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
383372005914	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
383372005915	Protein of unknown function (DUF422); Region: DUF422; cl00991
383372005916	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
383372005917	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
383372005918	putative acyl-acceptor binding pocket; other site
383372005919	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
383372005920	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372005921	metal ion-dependent adhesion site (MIDAS); other site
383372005922	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
383372005923	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372005924	metal ion-dependent adhesion site (MIDAS); other site
383372005925	Protein of unknown function DUF58; Region: DUF58; pfam01882
383372005926	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372005927	metal ion-dependent adhesion site (MIDAS); other site
383372005928	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
383372005929	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
383372005930	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647
383372005931	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
383372005932	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
383372005933	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
383372005934	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
383372005935	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
383372005936	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
383372005937	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
383372005938	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
383372005939	active site
383372005940	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372005941	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372005942	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
383372005943	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
383372005944	putative active site [active]
383372005945	metal binding site [ion binding]; metal-binding site
383372005946	Predicted membrane protein [Function unknown]; Region: COG3463
383372005947	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
383372005948	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
383372005949	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
383372005950	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
383372005951	active site
383372005952	Transcriptional regulator [Transcription]; Region: LytR; COG1316
383372005953	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
383372005954	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372005955	putative active site [active]
383372005956	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
383372005957	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
383372005958	active site
383372005959	homodimer interface [polypeptide binding]; other site
383372005960	catalytic site [active]
383372005961	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
383372005962	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
383372005963	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372005964	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
383372005965	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
383372005966	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
383372005967	Ribosomal protein L31; Region: Ribosomal_L31; pfam01197
383372005968	Predicted transcriptional regulator [Transcription]; Region: COG2378
383372005969	HTH domain; Region: HTH_11; pfam08279
383372005970	WYL domain; Region: WYL; pfam13280
383372005971	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
383372005972	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
383372005973	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
383372005974	NAD(P) binding site [chemical binding]; other site
383372005975	hypothetical protein; Provisional; Region: PRK14678
383372005976	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
383372005977	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
383372005978	putative trimer interface [polypeptide binding]; other site
383372005979	putative active site [active]
383372005980	putative substrate binding site [chemical binding]; other site
383372005981	putative CoA binding site [chemical binding]; other site
383372005982	FOG: CBS domain [General function prediction only]; Region: COG0517
383372005983	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
383372005984	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
383372005985	DNA methylase; Region: N6_N4_Mtase; pfam01555
383372005986	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
383372005987	E3 interaction surface; other site
383372005988	lipoyl attachment site [posttranslational modification]; other site
383372005989	e3 binding domain; Region: E3_binding; pfam02817
383372005990	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
383372005991	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
383372005992	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
383372005993	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
383372005994	alpha subunit interface [polypeptide binding]; other site
383372005995	TPP binding site [chemical binding]; other site
383372005996	heterodimer interface [polypeptide binding]; other site
383372005997	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
383372005998	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
383372005999	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
383372006000	tetramer interface [polypeptide binding]; other site
383372006001	TPP-binding site [chemical binding]; other site
383372006002	heterodimer interface [polypeptide binding]; other site
383372006003	phosphorylation loop region [posttranslational modification]
383372006004	DHH family; Region: DHH; pfam01368
383372006005	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
383372006006	RNA binding site [nucleotide binding]; other site
383372006007	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
383372006008	RNA binding site [nucleotide binding]; other site
383372006009	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
383372006010	RNA binding site [nucleotide binding]; other site
383372006011	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
383372006012	RNA binding site [nucleotide binding]; other site
383372006013	Clp protease ATP binding subunit; Region: clpC; CHL00095
383372006014	Clp amino terminal domain; Region: Clp_N; pfam02861
383372006015	Clp amino terminal domain; Region: Clp_N; pfam02861
383372006016	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372006017	Walker A motif; other site
383372006018	ATP binding site [chemical binding]; other site
383372006019	Walker B motif; other site
383372006020	arginine finger; other site
383372006021	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372006022	Walker A motif; other site
383372006023	ATP binding site [chemical binding]; other site
383372006024	Walker B motif; other site
383372006025	arginine finger; other site
383372006026	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
383372006027	DNA repair protein RadA; Provisional; Region: PRK11823
383372006028	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
383372006029	Walker A motif/ATP binding site; other site
383372006030	ATP binding site [chemical binding]; other site
383372006031	Walker B motif; other site
383372006032	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
383372006033	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
383372006034	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
383372006035	putative active site [active]
383372006036	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
383372006037	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
383372006038	inhibitor-cofactor binding pocket; inhibition site
383372006039	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372006040	catalytic residue [active]
383372006041	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
383372006042	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
383372006043	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
383372006044	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
383372006045	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
383372006046	metal binding site [ion binding]; metal-binding site
383372006047	dimer interface [polypeptide binding]; other site
383372006048	intracellular protease, PfpI family; Region: PfpI; TIGR01382
383372006049	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
383372006050	conserved cys residue [active]
383372006051	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
383372006052	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
383372006053	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
383372006054	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
383372006055	DNA binding residues [nucleotide binding]
383372006056	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
383372006057	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
383372006058	tRNA; other site
383372006059	putative tRNA binding site [nucleotide binding]; other site
383372006060	putative NADP binding site [chemical binding]; other site
383372006061	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
383372006062	Chlorite dismutase; Region: Chlor_dismutase; cl01280
383372006063	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
383372006064	substrate binding site [chemical binding]; other site
383372006065	active site
383372006066	Ferrochelatase; Region: Ferrochelatase; pfam00762
383372006067	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
383372006068	C-terminal domain interface [polypeptide binding]; other site
383372006069	active site
383372006070	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
383372006071	active site
383372006072	N-terminal domain interface [polypeptide binding]; other site
383372006073	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
383372006074	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
383372006075	domain interfaces; other site
383372006076	active site
383372006077	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
383372006078	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
383372006079	active site
383372006080	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
383372006081	dimer interface [polypeptide binding]; other site
383372006082	active site
383372006083	Schiff base residues; other site
383372006084	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
383372006085	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
383372006086	inhibitor-cofactor binding pocket; inhibition site
383372006087	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372006088	catalytic residue [active]
383372006089	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
383372006090	Leucine carboxyl methyltransferase; Region: LCM; cl01306
383372006091	Putative zinc-finger; Region: zf-HC2; pfam13490
383372006092	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
383372006093	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372006094	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372006095	DNA binding residues [nucleotide binding]
383372006096	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
383372006097	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
383372006098	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
383372006099	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
383372006100	homodimer interface [polypeptide binding]; other site
383372006101	substrate-cofactor binding pocket; other site
383372006102	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372006103	catalytic residue [active]
383372006104	Probable zinc-binding domain; Region: zf-trcl; pfam13451
383372006105	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
383372006106	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
383372006107	GAF domain; Region: GAF; pfam01590
383372006108	PAS domain; Region: PAS; smart00091
383372006109	putative active site [active]
383372006110	heme pocket [chemical binding]; other site
383372006111	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372006112	Walker A motif; other site
383372006113	ATP binding site [chemical binding]; other site
383372006114	Walker B motif; other site
383372006115	arginine finger; other site
383372006116	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
383372006117	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
383372006118	amphipathic channel; other site
383372006119	Asn-Pro-Ala signature motifs; other site
383372006120	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
383372006121	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
383372006122	DAK2 domain; Region: Dak2; cl03685
383372006123	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
383372006124	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
383372006125	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
383372006126	active site
383372006127	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
383372006128	dimerization domain swap beta strand [polypeptide binding]; other site
383372006129	regulatory protein interface [polypeptide binding]; other site
383372006130	active site
383372006131	regulatory phosphorylation site [posttranslational modification]; other site
383372006132	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
383372006133	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
383372006134	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
383372006135	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
383372006136	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
383372006137	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
383372006138	dimer interface [polypeptide binding]; other site
383372006139	ssDNA binding site [nucleotide binding]; other site
383372006140	tetramer (dimer of dimers) interface [polypeptide binding]; other site
383372006141	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
383372006142	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
383372006143	putative substrate binding pocket [chemical binding]; other site
383372006144	AC domain interface; other site
383372006145	catalytic triad [active]
383372006146	AB domain interface; other site
383372006147	interchain disulfide; other site
383372006148	prolyl-tRNA synthetase; Provisional; Region: PRK08661
383372006149	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
383372006150	dimer interface [polypeptide binding]; other site
383372006151	motif 1; other site
383372006152	active site
383372006153	motif 2; other site
383372006154	motif 3; other site
383372006155	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
383372006156	anticodon binding site; other site
383372006157	zinc-binding site [ion binding]; other site
383372006158	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372006159	putative active site [active]
383372006160	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
383372006161	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
383372006162	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
383372006163	substrate binding site [chemical binding]; other site
383372006164	hexamer interface [polypeptide binding]; other site
383372006165	metal binding site [ion binding]; metal-binding site
383372006166	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372006167	putative substrate translocation pore; other site
383372006168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372006169	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372006170	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372006171	phosphopeptide binding site; other site
383372006172	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
383372006173	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372006174	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372006175	phosphopeptide binding site; other site
383372006176	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
383372006177	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
383372006178	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
383372006179	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
383372006180	putative active site [active]
383372006181	putative FMN binding site [chemical binding]; other site
383372006182	putative substrate binding site [chemical binding]; other site
383372006183	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
383372006184	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
383372006185	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
383372006186	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
383372006187	ligand binding site [chemical binding]; other site
383372006188	flexible hinge region; other site
383372006189	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
383372006190	Metallopeptidase family M24; Region: Peptidase_M24; pfam00557
383372006191	active site
383372006192	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
383372006193	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372006194	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372006195	DNA binding residues [nucleotide binding]
383372006196	Phosphoglycerate kinase; Region: PGK; pfam00162
383372006197	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
383372006198	substrate binding site [chemical binding]; other site
383372006199	hinge regions; other site
383372006200	ADP binding site [chemical binding]; other site
383372006201	catalytic site [active]
383372006202	classical (c) SDRs; Region: SDR_c; cd05233
383372006203	NAD(P) binding site [chemical binding]; other site
383372006204	active site
383372006205	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
383372006206	active site
383372006207	nucleotide binding site [chemical binding]; other site
383372006208	HIGH motif; other site
383372006209	KMSKS motif; other site
383372006210	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
383372006211	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
383372006212	probable polyamine oxidase; Region: PLN02268
383372006213	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
383372006214	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
383372006215	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
383372006216	NADP binding site [chemical binding]; other site
383372006217	dimer interface [polypeptide binding]; other site
383372006218	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
383372006219	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
383372006220	Probable transposase; Region: OrfB_IS605; pfam01385
383372006221	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
383372006222	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
383372006223	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
383372006224	active site
383372006225	catalytic site [active]
383372006226	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
383372006227	Double zinc ribbon; Region: DZR; pfam12773
383372006228	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
383372006229	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
383372006230	active site residue [active]
383372006231	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
383372006232	active site residue [active]
383372006233	Sulphur transport; Region: Sulf_transp; pfam04143
383372006234	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
383372006235	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
383372006236	active site
383372006237	catalytic triad [active]
383372006238	dimer interface [polypeptide binding]; other site
383372006239	NurA domain; Region: NurA; pfam09376
383372006240	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
383372006241	UbiA prenyltransferase family; Region: UbiA; pfam01040
383372006242	homoserine dehydrogenase; Provisional; Region: PRK06270
383372006243	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
383372006244	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
383372006245	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
383372006246	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372006247	Coenzyme A binding pocket [chemical binding]; other site
383372006248	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
383372006249	NADH dehydrogenase subunit B; Provisional; Region: PRK14819
383372006250	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
383372006251	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
383372006252	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
383372006253	NADH dehydrogenase subunit D; Validated; Region: PRK06075
383372006254	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
383372006255	4Fe-4S binding domain; Region: Fer4; pfam00037
383372006256	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
383372006257	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
383372006258	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
383372006259	NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499
383372006260	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
383372006261	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
383372006262	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
383372006263	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
383372006264	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
383372006265	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
383372006266	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
383372006267	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
383372006268	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
383372006269	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
383372006270	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
383372006271	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
383372006272	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
383372006273	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
383372006274	CAAX protease self-immunity; Region: Abi; pfam02517
383372006275	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
383372006276	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
383372006277	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
383372006278	short chain dehydrogenase; Provisional; Region: PRK08219
383372006279	Tthb094 and related proteins, classical (c) SDRs; Region: Tthb094_like_SDR_c; cd11730
383372006280	NAD(P) binding site [chemical binding]; other site
383372006281	putative active site [active]
383372006282	AAA domain; Region: AAA_32; pfam13654
383372006283	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
383372006284	agmatinase; Region: agmatinase; TIGR01230
383372006285	oligomer interface [polypeptide binding]; other site
383372006286	putative active site [active]
383372006287	Mn binding site [ion binding]; other site
383372006288	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
383372006289	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
383372006290	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
383372006291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372006292	dimer interface [polypeptide binding]; other site
383372006293	conserved gate region; other site
383372006294	putative PBP binding loops; other site
383372006295	ABC-ATPase subunit interface; other site
383372006296	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
383372006297	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
383372006298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372006299	dimer interface [polypeptide binding]; other site
383372006300	conserved gate region; other site
383372006301	putative PBP binding loops; other site
383372006302	ABC-ATPase subunit interface; other site
383372006303	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
383372006304	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
383372006305	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
383372006306	Walker A/P-loop; other site
383372006307	ATP binding site [chemical binding]; other site
383372006308	Q-loop/lid; other site
383372006309	ABC transporter signature motif; other site
383372006310	Walker B; other site
383372006311	D-loop; other site
383372006312	H-loop/switch region; other site
383372006313	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
383372006314	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
383372006315	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
383372006316	ligand binding site [chemical binding]; other site
383372006317	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
383372006318	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
383372006319	TM-ABC transporter signature motif; other site
383372006320	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
383372006321	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
383372006322	metal binding site [ion binding]; metal-binding site
383372006323	substrate binding pocket [chemical binding]; other site
383372006324	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
383372006325	classical (c) SDRs; Region: SDR_c; cd05233
383372006326	NAD(P) binding site [chemical binding]; other site
383372006327	active site
383372006328	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
383372006329	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
383372006330	Transcriptional regulators [Transcription]; Region: GntR; COG1802
383372006331	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
383372006332	DNA-binding site [nucleotide binding]; DNA binding site
383372006333	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
383372006334	Bacterial transcriptional activator domain; Region: BTAD; smart01043
383372006335	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817
383372006336	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
383372006337	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
383372006338	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
383372006339	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
383372006340	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
383372006341	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
383372006342	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
383372006343	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372006344	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372006345	phosphopeptide binding site; other site
383372006346	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
383372006347	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372006348	metal ion-dependent adhesion site (MIDAS); other site
383372006349	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372006350	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372006351	active site
383372006352	ATP binding site [chemical binding]; other site
383372006353	substrate binding site [chemical binding]; other site
383372006354	activation loop (A-loop); other site
383372006355	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
383372006356	active site
383372006357	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
383372006358	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817
383372006359	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
383372006360	CHAP domain; Region: CHAP; cl17642
383372006361	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
383372006362	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
383372006363	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
383372006364	C-terminal peptidase (prc); Region: prc; TIGR00225
383372006365	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
383372006366	protein binding site [polypeptide binding]; other site
383372006367	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
383372006368	Catalytic dyad [active]
383372006369	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
383372006370	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
383372006371	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
383372006372	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
383372006373	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
383372006374	active site
383372006375	HIGH motif; other site
383372006376	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
383372006377	KMSKS motif; other site
383372006378	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
383372006379	tRNA binding surface [nucleotide binding]; other site
383372006380	anticodon binding site; other site
383372006381	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
383372006382	serine O-acetyltransferase; Region: cysE; TIGR01172
383372006383	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
383372006384	trimer interface [polypeptide binding]; other site
383372006385	active site
383372006386	substrate binding site [chemical binding]; other site
383372006387	CoA binding site [chemical binding]; other site
383372006388	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
383372006389	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
383372006390	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
383372006391	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
383372006392	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
383372006393	Peptidase family M23; Region: Peptidase_M23; pfam01551
383372006394	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
383372006395	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
383372006396	Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: GCD2; COG1184
383372006397	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
383372006398	Response regulator receiver domain; Region: Response_reg; pfam00072
383372006399	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372006400	active site
383372006401	phosphorylation site [posttranslational modification]
383372006402	intermolecular recognition site; other site
383372006403	dimerization interface [polypeptide binding]; other site
383372006404	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372006405	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372006406	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
383372006407	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372006408	putative active site [active]
383372006409	heme pocket [chemical binding]; other site
383372006410	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372006411	dimer interface [polypeptide binding]; other site
383372006412	phosphorylation site [posttranslational modification]
383372006413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372006414	ATP binding site [chemical binding]; other site
383372006415	Mg2+ binding site [ion binding]; other site
383372006416	G-X-G motif; other site
383372006417	Response regulator receiver domain; Region: Response_reg; pfam00072
383372006418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372006419	active site
383372006420	phosphorylation site [posttranslational modification]
383372006421	intermolecular recognition site; other site
383372006422	dimerization interface [polypeptide binding]; other site
383372006423	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
383372006424	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
383372006425	protein binding site [polypeptide binding]; other site
383372006426	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
383372006427	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
383372006428	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
383372006429	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
383372006430	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
383372006431	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
383372006432	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
383372006433	glutamine binding [chemical binding]; other site
383372006434	catalytic triad [active]
383372006435	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
383372006436	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
383372006437	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
383372006438	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
383372006439	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
383372006440	active site
383372006441	HIGH motif; other site
383372006442	dimer interface [polypeptide binding]; other site
383372006443	KMSKS motif; other site
383372006444	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
383372006445	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
383372006446	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
383372006447	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372006448	catalytic residue [active]
383372006449	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372006450	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372006451	phosphopeptide binding site; other site
383372006452	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
383372006453	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
383372006454	metal ion-dependent adhesion site (MIDAS); other site
383372006455	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
383372006456	active site
383372006457	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372006458	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372006459	active site
383372006460	ATP binding site [chemical binding]; other site
383372006461	substrate binding site [chemical binding]; other site
383372006462	activation loop (A-loop); other site
383372006463	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
383372006464	Trp docking motif [polypeptide binding]; other site
383372006465	active site
383372006466	PQQ-like domain; Region: PQQ_2; pfam13360
383372006467	Bacterial SH3 domain homologues; Region: SH3b; smart00287
383372006468	Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277
383372006469	WYL domain; Region: WYL; pfam13280
383372006470	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
383372006471	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372006472	Walker A motif; other site
383372006473	ATP binding site [chemical binding]; other site
383372006474	Walker B motif; other site
383372006475	arginine finger; other site
383372006476	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
383372006477	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
383372006478	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
383372006479	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
383372006480	4Fe-4S binding domain; Region: Fer4; pfam00037
383372006481	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
383372006482	This CD includes the respiratory arsenate reductase, As(V), catalytic subunit (ArrA) and other related proteins. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_Arsenate-R; cd02757
383372006483	putative [Fe4-S4] binding site [ion binding]; other site
383372006484	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
383372006485	putative molybdopterin cofactor binding site [chemical binding]; other site
383372006486	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
383372006487	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
383372006488	putative molybdopterin cofactor binding site; other site
383372006489	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
383372006490	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
383372006491	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
383372006492	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
383372006493	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
383372006494	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
383372006495	Walker A/P-loop; other site
383372006496	ATP binding site [chemical binding]; other site
383372006497	Q-loop/lid; other site
383372006498	ABC transporter signature motif; other site
383372006499	Walker B; other site
383372006500	D-loop; other site
383372006501	H-loop/switch region; other site
383372006502	TOBE domain; Region: TOBE_2; pfam08402
383372006503	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
383372006504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372006505	dimer interface [polypeptide binding]; other site
383372006506	conserved gate region; other site
383372006507	putative PBP binding loops; other site
383372006508	ABC-ATPase subunit interface; other site
383372006509	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
383372006510	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
383372006511	Predicted transcriptional regulators [Transcription]; Region: COG1695
383372006512	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
383372006513	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
383372006514	Uncharacterized conserved protein [Function unknown]; Region: COG2006
383372006515	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
383372006516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372006517	dimer interface [polypeptide binding]; other site
383372006518	conserved gate region; other site
383372006519	putative PBP binding loops; other site
383372006520	ABC-ATPase subunit interface; other site
383372006521	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
383372006522	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
383372006523	Walker A/P-loop; other site
383372006524	ATP binding site [chemical binding]; other site
383372006525	Q-loop/lid; other site
383372006526	ABC transporter signature motif; other site
383372006527	Walker B; other site
383372006528	D-loop; other site
383372006529	H-loop/switch region; other site
383372006530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372006531	ABC-ATPase subunit interface; other site
383372006532	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
383372006533	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
383372006534	substrate binding pocket [chemical binding]; other site
383372006535	membrane-bound complex binding site; other site
383372006536	hinge residues; other site
383372006537	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
383372006538	Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904
383372006539	hypothetical protein; Provisional; Region: PRK08201
383372006540	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
383372006541	metal binding site [ion binding]; metal-binding site
383372006542	putative dimer interface [polypeptide binding]; other site
383372006543	short chain dehydrogenase; Validated; Region: PRK06182
383372006544	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
383372006545	NADP binding site [chemical binding]; other site
383372006546	active site
383372006547	steroid binding site; other site
383372006548	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
383372006549	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
383372006550	PYR/PP interface [polypeptide binding]; other site
383372006551	dimer interface [polypeptide binding]; other site
383372006552	TPP binding site [chemical binding]; other site
383372006553	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
383372006554	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
383372006555	TPP-binding site; other site
383372006556	dimer interface [polypeptide binding]; other site
383372006557	AAA domain; Region: AAA_14; pfam13173
383372006558	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
383372006559	L-tyrosine decarboxylase; Provisional; Region: PRK13520
383372006560	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
383372006561	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
383372006562	catalytic residue [active]
383372006563	MFS/sugar transport protein; Region: MFS_2; pfam13347
383372006564	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
383372006565	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
383372006566	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
383372006567	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372006568	putative active site [active]
383372006569	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372006570	putative active site [active]
383372006571	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372006572	putative active site [active]
383372006573	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372006574	putative active site [active]
383372006575	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
383372006576	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
383372006577	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
383372006578	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
383372006579	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
383372006580	Cna protein B-type domain; Region: Cna_B; pfam05738
383372006581	Cna protein B-type domain; Region: Cna_B; pfam05738
383372006582	Cna protein B-type domain; Region: Cna_B; pfam05738
383372006583	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372006584	Cna protein B-type domain; Region: Cna_B; pfam05738
383372006585	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
383372006586	YhhN-like protein; Region: YhhN; pfam07947
383372006587	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
383372006588	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
383372006589	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372006590	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372006591	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372006592	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372006593	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372006594	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372006595	NAD synthetase; Reviewed; Region: nadE; PRK02628
383372006596	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
383372006597	multimer interface [polypeptide binding]; other site
383372006598	active site
383372006599	catalytic triad [active]
383372006600	protein interface 1 [polypeptide binding]; other site
383372006601	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
383372006602	homodimer interface [polypeptide binding]; other site
383372006603	NAD binding pocket [chemical binding]; other site
383372006604	ATP binding pocket [chemical binding]; other site
383372006605	Mg binding site [ion binding]; other site
383372006606	active-site loop [active]
383372006607	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372006608	putative active site [active]
383372006609	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
383372006610	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
383372006611	active site
383372006612	Beta-lactamase; Region: Beta-lactamase; pfam00144
383372006613	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
383372006614	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
383372006615	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
383372006616	putative ADP-binding pocket [chemical binding]; other site
383372006617	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
383372006618	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
383372006619	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
383372006620	NADP binding site [chemical binding]; other site
383372006621	dimer interface [polypeptide binding]; other site
383372006622	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
383372006623	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372006624	FeS/SAM binding site; other site
383372006625	recombination protein F; Reviewed; Region: recF; PRK00064
383372006626	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372006627	Walker A/P-loop; other site
383372006628	ATP binding site [chemical binding]; other site
383372006629	Q-loop/lid; other site
383372006630	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372006631	ABC transporter signature motif; other site
383372006632	Walker B; other site
383372006633	D-loop; other site
383372006634	H-loop/switch region; other site
383372006635	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
383372006636	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
383372006637	homotetramer interface [polypeptide binding]; other site
383372006638	FMN binding site [chemical binding]; other site
383372006639	homodimer contacts [polypeptide binding]; other site
383372006640	putative active site [active]
383372006641	putative substrate binding site [chemical binding]; other site
383372006642	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
383372006643	active site
383372006644	MutL protein; Region: MutL; pfam13941
383372006645	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
383372006646	putative active site [active]
383372006647	dimerization interface [polypeptide binding]; other site
383372006648	putative tRNAtyr binding site [nucleotide binding]; other site
383372006649	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
383372006650	CoenzymeA binding site [chemical binding]; other site
383372006651	subunit interaction site [polypeptide binding]; other site
383372006652	PHB binding site; other site
383372006653	XamI restriction endonuclease; Region: RE_XamI; pfam09572
383372006654	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
383372006655	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
383372006656	GIY-YIG motif/motif A; other site
383372006657	putative active site [active]
383372006658	putative metal binding site [ion binding]; other site
383372006659	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
383372006660	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
383372006661	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
383372006662	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
383372006663	DNA methylase; Region: N6_N4_Mtase; pfam01555
383372006664	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
383372006665	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
383372006666	Coenzyme A binding pocket [chemical binding]; other site
383372006667	Peptidase family M23; Region: Peptidase_M23; pfam01551
383372006668	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
383372006669	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
383372006670	Restriction endonuclease EcoRV; Region: Endonuc-EcoRV; pfam09233
383372006671	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
383372006672	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
383372006673	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
383372006674	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
383372006675	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
383372006676	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
383372006677	Chromate transporter; Region: Chromate_transp; pfam02417
383372006678	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
383372006679	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
383372006680	metal-binding site [ion binding]
383372006681	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
383372006682	Soluble P-type ATPase [General function prediction only]; Region: COG4087
383372006683	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
383372006684	Amidase; Region: Amidase; cl11426
383372006685	Protein of unknown function DUF72; Region: DUF72; pfam01904
383372006686	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
383372006687	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
383372006688	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
383372006689	putative ligand binding site [chemical binding]; other site
383372006690	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
383372006691	dimer interface [polypeptide binding]; other site
383372006692	[2Fe-2S] cluster binding site [ion binding]; other site
383372006693	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
383372006694	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
383372006695	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
383372006696	dimer interface [polypeptide binding]; other site
383372006697	putative PBP binding regions; other site
383372006698	ABC-ATPase subunit  interface; other site
383372006699	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
383372006700	Walker A/P-loop; other site
383372006701	ATP binding site [chemical binding]; other site
383372006702	ABC transporter; Region: ABC_tran; pfam00005
383372006703	Q-loop/lid; other site
383372006704	ABC transporter signature motif; other site
383372006705	Walker B; other site
383372006706	D-loop; other site
383372006707	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372006708	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372006709	phosphopeptide binding site; other site
383372006710	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372006711	GAF domain; Region: GAF_3; pfam13492
383372006712	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
383372006713	cyclase homology domain; Region: CHD; cd07302
383372006714	nucleotidyl binding site; other site
383372006715	metal binding site [ion binding]; metal-binding site
383372006716	dimer interface [polypeptide binding]; other site
383372006717	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
383372006718	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372006719	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372006720	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
383372006721	Maf-like protein; Region: Maf; pfam02545
383372006722	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
383372006723	active site
383372006724	dimer interface [polypeptide binding]; other site
383372006725	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372006726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372006727	active site
383372006728	phosphorylation site [posttranslational modification]
383372006729	intermolecular recognition site; other site
383372006730	dimerization interface [polypeptide binding]; other site
383372006731	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372006732	DNA binding residues [nucleotide binding]
383372006733	dimerization interface [polypeptide binding]; other site
383372006734	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
383372006735	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
383372006736	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372006737	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372006738	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
383372006739	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
383372006740	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
383372006741	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
383372006742	Na binding site [ion binding]; other site
383372006743	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
383372006744	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
383372006745	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
383372006746	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
383372006747	Predicted dehydrogenase [General function prediction only]; Region: COG0579
383372006748	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
383372006749	Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852
383372006750	active site
383372006751	catalytic triad [active]
383372006752	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
383372006753	PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120
383372006754	PA/protease or protease-like domain interface [polypeptide binding]; other site
383372006755	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
383372006756	catalytic residues [active]
383372006757	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
383372006758	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
383372006759	Clostripain family; Region: Peptidase_C11; pfam03415
383372006760	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
383372006761	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372006762	active site
383372006763	ATP binding site [chemical binding]; other site
383372006764	substrate binding site [chemical binding]; other site
383372006765	activation loop (A-loop); other site
383372006766	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372006767	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
383372006768	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
383372006769	putative metal binding site [ion binding]; other site
383372006770	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
383372006771	active site
383372006772	metal binding site [ion binding]; metal-binding site
383372006773	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
383372006774	tetramer interface [polypeptide binding]; other site
383372006775	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372006776	catalytic residue [active]
383372006777	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
383372006778	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
383372006779	tetramer interface [polypeptide binding]; other site
383372006780	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372006781	catalytic residue [active]
383372006782	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
383372006783	lipoyl attachment site [posttranslational modification]; other site
383372006784	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
383372006785	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
383372006786	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
383372006787	Response regulator receiver domain; Region: Response_reg; pfam00072
383372006788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372006789	active site
383372006790	phosphorylation site [posttranslational modification]
383372006791	intermolecular recognition site; other site
383372006792	dimerization interface [polypeptide binding]; other site
383372006793	Helix-turn-helix domain; Region: HTH_25; pfam13413
383372006794	HEAT repeats; Region: HEAT_2; pfam13646
383372006795	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372006796	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372006797	active site
383372006798	ATP binding site [chemical binding]; other site
383372006799	substrate binding site [chemical binding]; other site
383372006800	activation loop (A-loop); other site
383372006801	Domain of unknown function (DUF3524); Region: DUF3524; pfam12038
383372006802	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372006803	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372006804	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
383372006805	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
383372006806	recombination protein RecR; Reviewed; Region: recR; PRK00076
383372006807	helix-hairpin-helix signature motif; other site
383372006808	RecR protein; Region: RecR; pfam02132
383372006809	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
383372006810	putative active site [active]
383372006811	putative metal-binding site [ion binding]; other site
383372006812	tetramer interface [polypeptide binding]; other site
383372006813	hypothetical protein; Validated; Region: PRK00153
383372006814	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
383372006815	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372006816	Walker A motif; other site
383372006817	ATP binding site [chemical binding]; other site
383372006818	Walker B motif; other site
383372006819	arginine finger; other site
383372006820	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372006821	putative active site [active]
383372006822	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
383372006823	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
383372006824	Protein of unknown function (DUF692); Region: DUF692; cl01263
383372006825	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
383372006826	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
383372006827	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
383372006828	Walker A/P-loop; other site
383372006829	ATP binding site [chemical binding]; other site
383372006830	Q-loop/lid; other site
383372006831	ABC transporter signature motif; other site
383372006832	Walker B; other site
383372006833	D-loop; other site
383372006834	H-loop/switch region; other site
383372006835	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
383372006836	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
383372006837	Walker A/P-loop; other site
383372006838	ATP binding site [chemical binding]; other site
383372006839	Q-loop/lid; other site
383372006840	ABC transporter signature motif; other site
383372006841	Walker B; other site
383372006842	D-loop; other site
383372006843	H-loop/switch region; other site
383372006844	Putative cyclase; Region: Cyclase; pfam04199
383372006845	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
383372006846	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
383372006847	TM-ABC transporter signature motif; other site
383372006848	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
383372006849	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
383372006850	TM-ABC transporter signature motif; other site
383372006851	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
383372006852	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
383372006853	putative ligand binding site [chemical binding]; other site
383372006854	Transcriptional regulators [Transcription]; Region: GntR; COG1802
383372006855	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
383372006856	DNA-binding site [nucleotide binding]; DNA binding site
383372006857	FCD domain; Region: FCD; pfam07729
383372006858	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
383372006859	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
383372006860	Glutamate binding site [chemical binding]; other site
383372006861	homodimer interface [polypeptide binding]; other site
383372006862	NAD binding site [chemical binding]; other site
383372006863	catalytic residues [active]
383372006864	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
383372006865	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
383372006866	active site
383372006867	Zn binding site [ion binding]; other site
383372006868	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
383372006869	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
383372006870	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
383372006871	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
383372006872	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
383372006873	dimer interface [polypeptide binding]; other site
383372006874	PYR/PP interface [polypeptide binding]; other site
383372006875	TPP binding site [chemical binding]; other site
383372006876	substrate binding site [chemical binding]; other site
383372006877	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
383372006878	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
383372006879	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
383372006880	TPP-binding site [chemical binding]; other site
383372006881	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
383372006882	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
383372006883	dimerization interface [polypeptide binding]; other site
383372006884	putative DNA binding site [nucleotide binding]; other site
383372006885	putative Zn2+ binding site [ion binding]; other site
383372006886	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372006887	Coenzyme A binding pocket [chemical binding]; other site
383372006888	Methyltransferase domain; Region: Methyltransf_31; pfam13847
383372006889	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372006890	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372006891	putative substrate translocation pore; other site
383372006892	Major Facilitator Superfamily; Region: MFS_1; pfam07690
383372006893	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
383372006894	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
383372006895	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
383372006896	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
383372006897	dimerization interface [polypeptide binding]; other site
383372006898	putative DNA binding site [nucleotide binding]; other site
383372006899	putative Zn2+ binding site [ion binding]; other site
383372006900	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
383372006901	Low molecular weight phosphatase family; Region: LMWPc; cd00115
383372006902	active site
383372006903	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
383372006904	dimerization interface [polypeptide binding]; other site
383372006905	putative DNA binding site [nucleotide binding]; other site
383372006906	putative Zn2+ binding site [ion binding]; other site
383372006907	Low molecular weight phosphatase family; Region: LMWPc; cl00105
383372006908	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
383372006909	active site
383372006910	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
383372006911	substrate binding site [chemical binding]; other site
383372006912	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
383372006913	UV-endonuclease UvdE; Region: UvdE; cl10036
383372006914	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
383372006915	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
383372006916	HIGH motif; other site
383372006917	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
383372006918	active site
383372006919	KMSKS motif; other site
383372006920	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372006921	phosphopeptide binding site; other site
383372006922	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
383372006923	CBS domain; Region: CBS; pfam00571
383372006924	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
383372006925	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
383372006926	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
383372006927	substrate binding pocket [chemical binding]; other site
383372006928	chain length determination region; other site
383372006929	substrate-Mg2+ binding site; other site
383372006930	catalytic residues [active]
383372006931	aspartate-rich region 1; other site
383372006932	active site lid residues [active]
383372006933	aspartate-rich region 2; other site
383372006934	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
383372006935	catalytic core [active]
383372006936	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
383372006937	Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; Region: Peptidase_C1A; cd02248
383372006938	active site
383372006939	S2 subsite; other site
383372006940	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372006941	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372006942	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372006943	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372006944	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372006945	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
383372006946	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
383372006947	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
383372006948	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
383372006949	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
383372006950	active site
383372006951	homodimer interface [polypeptide binding]; other site
383372006952	catalytic site [active]
383372006953	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
383372006954	Interdomain contacts; other site
383372006955	Cytokine receptor motif; other site
383372006956	Fibronectin type III domain; Region: fn3; pfam00041
383372006957	Starch binding domain; Region: CBM_2; smart01065
383372006958	Protein of unknown function (DUF1626); Region: DUF1626; pfam07788
383372006959	PspC domain; Region: PspC; pfam04024
383372006960	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
383372006961	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
383372006962	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
383372006963	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
383372006964	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
383372006965	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
383372006966	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
383372006967	asparagine synthetase B; Provisional; Region: asnB; PRK09431
383372006968	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
383372006969	active site
383372006970	dimer interface [polypeptide binding]; other site
383372006971	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
383372006972	Ligand Binding Site [chemical binding]; other site
383372006973	Molecular Tunnel; other site
383372006974	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
383372006975	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
383372006976	dimerization interface [polypeptide binding]; other site
383372006977	DPS ferroxidase diiron center [ion binding]; other site
383372006978	ion pore; other site
383372006979	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
383372006980	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
383372006981	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
383372006982	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372006983	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
383372006984	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
383372006985	Sterol carrier protein domain; Region: SCP2_2; pfam13530
383372006986	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372006987	S-adenosylmethionine binding site [chemical binding]; other site
383372006988	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
383372006989	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372006990	Coenzyme A binding pocket [chemical binding]; other site
383372006991	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372006992	Coenzyme A binding pocket [chemical binding]; other site
383372006993	NB-ARC domain; Region: NB-ARC; pfam00931
383372006994	HEPN domain; Region: HEPN; pfam05168
383372006995	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372006996	active site
383372006997	NTP binding site [chemical binding]; other site
383372006998	metal binding triad [ion binding]; metal-binding site
383372006999	antibiotic binding site [chemical binding]; other site
383372007000	CHAT domain; Region: CHAT; cl17868
383372007001	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
383372007002	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
383372007003	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
383372007004	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372007005	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
383372007006	Walker A/P-loop; other site
383372007007	ATP binding site [chemical binding]; other site
383372007008	Q-loop/lid; other site
383372007009	ABC transporter signature motif; other site
383372007010	Walker B; other site
383372007011	D-loop; other site
383372007012	H-loop/switch region; other site
383372007013	GTPase RsgA; Reviewed; Region: PRK00098
383372007014	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
383372007015	RNA binding site [nucleotide binding]; other site
383372007016	homodimer interface [polypeptide binding]; other site
383372007017	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
383372007018	GTPase/Zn-binding domain interface [polypeptide binding]; other site
383372007019	GTP/Mg2+ binding site [chemical binding]; other site
383372007020	G4 box; other site
383372007021	G5 box; other site
383372007022	G1 box; other site
383372007023	Switch I region; other site
383372007024	G2 box; other site
383372007025	G3 box; other site
383372007026	Switch II region; other site
383372007027	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
383372007028	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
383372007029	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
383372007030	ABC-2 type transporter; Region: ABC2_membrane; cl17235
383372007031	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
383372007032	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
383372007033	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
383372007034	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
383372007035	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
383372007036	Beta-lactamase; Region: Beta-lactamase; pfam00144
383372007037	GAF domain; Region: GAF_3; pfam13492
383372007038	Predicted dehydrogenase [General function prediction only]; Region: COG5322
383372007039	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
383372007040	NAD(P) binding pocket [chemical binding]; other site
383372007041	Cytochrome c; Region: Cytochrom_C; pfam00034
383372007042	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
383372007043	TAP-like protein; Region: Abhydrolase_4; pfam08386
383372007044	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
383372007045	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
383372007046	P-loop; other site
383372007047	Magnesium ion binding site [ion binding]; other site
383372007048	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
383372007049	Magnesium ion binding site [ion binding]; other site
383372007050	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
383372007051	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
383372007052	phosphopeptide binding site; other site
383372007053	EVE domain; Region: EVE; pfam01878
383372007054	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
383372007055	translocation protein TolB; Provisional; Region: tolB; PRK04792
383372007056	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
383372007057	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
383372007058	Sulfate transporter family; Region: Sulfate_transp; pfam00916
383372007059	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
383372007060	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
383372007061	dimerization interface [polypeptide binding]; other site
383372007062	putative DNA binding site [nucleotide binding]; other site
383372007063	putative Zn2+ binding site [ion binding]; other site
383372007064	PAS fold; Region: PAS_4; pfam08448
383372007065	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372007066	putative active site [active]
383372007067	heme pocket [chemical binding]; other site
383372007068	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372007069	PAS domain; Region: PAS_9; pfam13426
383372007070	putative active site [active]
383372007071	heme pocket [chemical binding]; other site
383372007072	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372007073	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
383372007074	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
383372007075	Cupin; Region: Cupin_6; pfam12852
383372007076	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
383372007077	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
383372007078	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
383372007079	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
383372007080	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
383372007081	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
383372007082	VanW like protein; Region: VanW; pfam04294
383372007083	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
383372007084	Active_site [active]
383372007085	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
383372007086	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
383372007087	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
383372007088	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
383372007089	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
383372007090	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
383372007091	NMT1/THI5 like; Region: NMT1; pfam09084
383372007092	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
383372007093	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372007094	dimer interface [polypeptide binding]; other site
383372007095	conserved gate region; other site
383372007096	putative PBP binding loops; other site
383372007097	ABC-ATPase subunit interface; other site
383372007098	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
383372007099	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
383372007100	nucleotide binding site [chemical binding]; other site
383372007101	Double zinc ribbon; Region: DZR; pfam12773
383372007102	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372007103	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
383372007104	Protein phosphatase 2C; Region: PP2C; pfam00481
383372007105	active site
383372007106	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372007107	Double zinc ribbon; Region: DZR; pfam12773
383372007108	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372007109	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
383372007110	Protein phosphatase 2C; Region: PP2C; pfam00481
383372007111	active site
383372007112	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372007113	Double zinc ribbon; Region: DZR; pfam12773
383372007114	Protein kinase domain; Region: Pkinase; pfam00069
383372007115	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372007116	active site
383372007117	ATP binding site [chemical binding]; other site
383372007118	substrate binding site [chemical binding]; other site
383372007119	activation loop (A-loop); other site
383372007120	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
383372007121	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
383372007122	metal ion-dependent adhesion site (MIDAS); other site
383372007123	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372007124	Double zinc ribbon; Region: DZR; pfam12773
383372007125	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372007126	Double zinc ribbon; Region: DZR; pfam12773
383372007127	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372007128	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372007129	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372007130	phosphopeptide binding site; other site
383372007131	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
383372007132	hypothetical protein; Provisional; Region: PRK02399
383372007133	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
383372007134	YtkA-like; Region: YtkA; pfam13115
383372007135	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
383372007136	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
383372007137	intracellular protease, PfpI family; Region: PfpI; TIGR01382
383372007138	proposed catalytic triad [active]
383372007139	conserved cys residue [active]
383372007140	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
383372007141	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
383372007142	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
383372007143	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
383372007144	NAD binding site [chemical binding]; other site
383372007145	catalytic residues [active]
383372007146	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
383372007147	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
383372007148	active site 1 [active]
383372007149	dimer interface [polypeptide binding]; other site
383372007150	hexamer interface [polypeptide binding]; other site
383372007151	active site 2 [active]
383372007152	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
383372007153	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
383372007154	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
383372007155	active site
383372007156	catalytic residues [active]
383372007157	metal binding site [ion binding]; metal-binding site
383372007158	DmpG-like communication domain; Region: DmpG_comm; pfam07836
383372007159	acetaldehyde dehydrogenase; Validated; Region: PRK08300
383372007160	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
383372007161	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
383372007162	Transcriptional regulator [Transcription]; Region: IclR; COG1414
383372007163	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
383372007164	Bacterial transcriptional regulator; Region: IclR; pfam01614
383372007165	N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013
383372007166	tetramer interface [polypeptide binding]; other site
383372007167	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
383372007168	C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014
383372007169	tetramer interface [polypeptide binding]; other site
383372007170	active site
383372007171	metal binding site [ion binding]; metal-binding site
383372007172	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
383372007173	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
383372007174	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372007175	active site
383372007176	NTP binding site [chemical binding]; other site
383372007177	metal binding triad [ion binding]; metal-binding site
383372007178	antibiotic binding site [chemical binding]; other site
383372007179	Protein of unknown function DUF86; Region: DUF86; cl01031
383372007180	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
383372007181	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
383372007182	Walker A/P-loop; other site
383372007183	ATP binding site [chemical binding]; other site
383372007184	Q-loop/lid; other site
383372007185	ABC transporter signature motif; other site
383372007186	Walker B; other site
383372007187	D-loop; other site
383372007188	H-loop/switch region; other site
383372007189	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
383372007190	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
383372007191	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
383372007192	Walker A/P-loop; other site
383372007193	ATP binding site [chemical binding]; other site
383372007194	Q-loop/lid; other site
383372007195	ABC transporter signature motif; other site
383372007196	Walker B; other site
383372007197	D-loop; other site
383372007198	H-loop/switch region; other site
383372007199	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
383372007200	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
383372007201	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
383372007202	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372007203	dimer interface [polypeptide binding]; other site
383372007204	conserved gate region; other site
383372007205	putative PBP binding loops; other site
383372007206	ABC-ATPase subunit interface; other site
383372007207	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
383372007208	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372007209	dimer interface [polypeptide binding]; other site
383372007210	conserved gate region; other site
383372007211	putative PBP binding loops; other site
383372007212	ABC-ATPase subunit interface; other site
383372007213	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
383372007214	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
383372007215	peptide chain release factor 1; Validated; Region: prfA; PRK00591
383372007216	This domain is found in peptide chain release factors; Region: PCRF; smart00937
383372007217	RF-1 domain; Region: RF-1; pfam00472
383372007218	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
383372007219	adenosine deaminase; Provisional; Region: PRK09358
383372007220	active site
383372007221	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
383372007222	catalytic center binding site [active]
383372007223	ATP binding site [chemical binding]; other site
383372007224	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
383372007225	hydrophobic ligand binding site; other site
383372007226	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
383372007227	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
383372007228	active site
383372007229	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
383372007230	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
383372007231	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
383372007232	dihydroorotase; Validated; Region: pyrC; PRK09357
383372007233	Amidohydrolase; Region: Amidohydro_5; pfam13594
383372007234	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
383372007235	active site
383372007236	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
383372007237	FAD binding pocket [chemical binding]; other site
383372007238	conserved FAD binding motif [chemical binding]; other site
383372007239	phosphate binding motif [ion binding]; other site
383372007240	beta-alpha-beta structure motif; other site
383372007241	NAD binding pocket [chemical binding]; other site
383372007242	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
383372007243	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
383372007244	quinone interaction residues [chemical binding]; other site
383372007245	active site
383372007246	catalytic residues [active]
383372007247	FMN binding site [chemical binding]; other site
383372007248	substrate binding site [chemical binding]; other site
383372007249	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
383372007250	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
383372007251	active site
383372007252	octamer interface [polypeptide binding]; other site
383372007253	Uncharacterized conserved protein [Function unknown]; Region: COG3375
383372007254	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
383372007255	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372007256	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372007257	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372007258	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372007259	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372007260	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
383372007261	Cupin domain; Region: Cupin_2; cl17218
383372007262	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
383372007263	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
383372007264	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
383372007265	NAD(P) binding site [chemical binding]; other site
383372007266	LDH/MDH dimer interface [polypeptide binding]; other site
383372007267	substrate binding site [chemical binding]; other site
383372007268	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
383372007269	B12 binding site [chemical binding]; other site
383372007270	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
383372007271	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
383372007272	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
383372007273	Walker A/P-loop; other site
383372007274	ATP binding site [chemical binding]; other site
383372007275	Q-loop/lid; other site
383372007276	ABC transporter signature motif; other site
383372007277	Walker B; other site
383372007278	D-loop; other site
383372007279	H-loop/switch region; other site
383372007280	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
383372007281	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
383372007282	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
383372007283	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372007284	dimer interface [polypeptide binding]; other site
383372007285	conserved gate region; other site
383372007286	putative PBP binding loops; other site
383372007287	ABC-ATPase subunit interface; other site
383372007288	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
383372007289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372007290	dimer interface [polypeptide binding]; other site
383372007291	conserved gate region; other site
383372007292	putative PBP binding loops; other site
383372007293	ABC-ATPase subunit interface; other site
383372007294	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
383372007295	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
383372007296	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
383372007297	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
383372007298	Walker A/P-loop; other site
383372007299	ATP binding site [chemical binding]; other site
383372007300	Q-loop/lid; other site
383372007301	ABC transporter signature motif; other site
383372007302	Walker B; other site
383372007303	D-loop; other site
383372007304	H-loop/switch region; other site
383372007305	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
383372007306	Transcriptional regulators [Transcription]; Region: PurR; COG1609
383372007307	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
383372007308	DNA binding site [nucleotide binding]
383372007309	domain linker motif; other site
383372007310	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
383372007311	dimerization interface [polypeptide binding]; other site
383372007312	ligand binding site [chemical binding]; other site
383372007313	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372007314	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372007315	Protein of unknown function (DUF993); Region: DUF993; pfam06187
383372007316	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
383372007317	PAS fold; Region: PAS_4; pfam08448
383372007318	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
383372007319	putative active site [active]
383372007320	heme pocket [chemical binding]; other site
383372007321	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372007322	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
383372007323	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
383372007324	active site
383372007325	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372007326	active site
383372007327	NTP binding site [chemical binding]; other site
383372007328	metal binding triad [ion binding]; metal-binding site
383372007329	antibiotic binding site [chemical binding]; other site
383372007330	Protein of unknown function DUF86; Region: DUF86; cl01031
383372007331	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372007332	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372007333	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372007334	DHH family; Region: DHH; pfam01368
383372007335	FOG: CBS domain [General function prediction only]; Region: COG0517
383372007336	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
383372007337	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
383372007338	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
383372007339	active site
383372007340	NTP binding site [chemical binding]; other site
383372007341	metal binding triad [ion binding]; metal-binding site
383372007342	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
383372007343	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
383372007344	DNA protecting protein DprA; Region: dprA; TIGR00732
383372007345	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
383372007346	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
383372007347	ATP binding site [chemical binding]; other site
383372007348	putative Mg++ binding site [ion binding]; other site
383372007349	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
383372007350	nucleotide binding region [chemical binding]; other site
383372007351	ATP-binding site [chemical binding]; other site
383372007352	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
383372007353	active site
383372007354	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372007355	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372007356	putative active site [active]
383372007357	heme pocket [chemical binding]; other site
383372007358	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372007359	dimer interface [polypeptide binding]; other site
383372007360	phosphorylation site [posttranslational modification]
383372007361	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372007362	ATP binding site [chemical binding]; other site
383372007363	Mg2+ binding site [ion binding]; other site
383372007364	G-X-G motif; other site
383372007365	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
383372007366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372007367	active site
383372007368	phosphorylation site [posttranslational modification]
383372007369	intermolecular recognition site; other site
383372007370	dimerization interface [polypeptide binding]; other site
383372007371	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372007372	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372007373	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372007374	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372007375	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372007376	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372007377	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
383372007378	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
383372007379	metal binding site [ion binding]; metal-binding site
383372007380	active site
383372007381	I-site; other site
383372007382	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372007383	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
383372007384	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372007385	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
383372007386	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
383372007387	dimer interface [polypeptide binding]; other site
383372007388	active site
383372007389	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
383372007390	catalytic residues [active]
383372007391	substrate binding site [chemical binding]; other site
383372007392	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
383372007393	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
383372007394	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372007395	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
383372007396	AAA domain; Region: AAA_14; pfam13173
383372007397	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
383372007398	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
383372007399	homodimer interface [polypeptide binding]; other site
383372007400	substrate-cofactor binding pocket; other site
383372007401	catalytic residue [active]
383372007402	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
383372007403	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
383372007404	dimer interface [polypeptide binding]; other site
383372007405	active site
383372007406	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372007407	putative active site [active]
383372007408	pyruvate phosphate dikinase; Provisional; Region: PRK09279
383372007409	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
383372007410	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
383372007411	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
383372007412	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372007413	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372007414	Major Facilitator Superfamily; Region: MFS_1; pfam07690
383372007415	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
383372007416	Domain of unknown function DUF20; Region: UPF0118; pfam01594
383372007417	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
383372007418	active site
383372007419	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372007420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372007421	active site
383372007422	phosphorylation site [posttranslational modification]
383372007423	intermolecular recognition site; other site
383372007424	dimerization interface [polypeptide binding]; other site
383372007425	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372007426	DNA binding site [nucleotide binding]
383372007427	short chain dehydrogenase; Provisional; Region: PRK06172
383372007428	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372007429	NAD(P) binding site [chemical binding]; other site
383372007430	active site
383372007431	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
383372007432	Peptidase family M23; Region: Peptidase_M23; pfam01551
383372007433	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
383372007434	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
383372007435	Malic enzyme, N-terminal domain; Region: malic; pfam00390
383372007436	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
383372007437	putative NAD(P) binding site [chemical binding]; other site
383372007438	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
383372007439	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
383372007440	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
383372007441	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
383372007442	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
383372007443	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
383372007444	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
383372007445	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
383372007446	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
383372007447	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372007448	dimerization interface [polypeptide binding]; other site
383372007449	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372007450	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
383372007451	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
383372007452	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
383372007453	Walker A/P-loop; other site
383372007454	ATP binding site [chemical binding]; other site
383372007455	Q-loop/lid; other site
383372007456	ABC transporter signature motif; other site
383372007457	Walker B; other site
383372007458	D-loop; other site
383372007459	H-loop/switch region; other site
383372007460	Domain of unknown function (DUF385); Region: DUF385; pfam04075
383372007461	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
383372007462	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
383372007463	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372007464	Walker A/P-loop; other site
383372007465	ATP binding site [chemical binding]; other site
383372007466	Q-loop/lid; other site
383372007467	ABC transporter signature motif; other site
383372007468	Walker B; other site
383372007469	D-loop; other site
383372007470	H-loop/switch region; other site
383372007471	MarR family; Region: MarR; pfam01047
383372007472	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
383372007473	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
383372007474	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
383372007475	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
383372007476	Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287
383372007477	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372007478	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372007479	S-adenosylmethionine binding site [chemical binding]; other site
383372007480	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
383372007481	Protein of unknown function DUF58; Region: DUF58; pfam01882
383372007482	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
383372007483	MoxR-like ATPases [General function prediction only]; Region: COG0714
383372007484	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372007485	Walker A motif; other site
383372007486	ATP binding site [chemical binding]; other site
383372007487	Walker B motif; other site
383372007488	arginine finger; other site
383372007489	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
383372007490	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
383372007491	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
383372007492	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
383372007493	active site
383372007494	ADP/pyrophosphate binding site [chemical binding]; other site
383372007495	dimerization interface [polypeptide binding]; other site
383372007496	allosteric effector site; other site
383372007497	fructose-1,6-bisphosphate binding site; other site
383372007498	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858
383372007499	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
383372007500	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
383372007501	active site
383372007502	ADP/pyrophosphate binding site [chemical binding]; other site
383372007503	dimerization interface [polypeptide binding]; other site
383372007504	allosteric effector site; other site
383372007505	fructose-1,6-bisphosphate binding site; other site
383372007506	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
383372007507	Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340
383372007508	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
383372007509	DNA methylase; Region: N6_N4_Mtase; pfam01555
383372007510	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
383372007511	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
383372007512	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
383372007513	MgtE intracellular N domain; Region: MgtE_N; pfam03448
383372007514	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
383372007515	Divalent cation transporter; Region: MgtE; pfam01769
383372007516	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372007517	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372007518	phosphopeptide binding site; other site
383372007519	Peptidase C26; Region: Peptidase_C26; pfam07722
383372007520	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
383372007521	catalytic triad [active]
383372007522	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
383372007523	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
383372007524	ATP-grasp domain; Region: ATP-grasp; pfam02222
383372007525	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
383372007526	tandem repeat interface [polypeptide binding]; other site
383372007527	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
383372007528	oligomer interface [polypeptide binding]; other site
383372007529	active site residues [active]
383372007530	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
383372007531	tandem repeat interface [polypeptide binding]; other site
383372007532	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
383372007533	oligomer interface [polypeptide binding]; other site
383372007534	active site residues [active]
383372007535	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
383372007536	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
383372007537	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
383372007538	ABC-ATPase subunit interface; other site
383372007539	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
383372007540	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
383372007541	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
383372007542	Walker A/P-loop; other site
383372007543	ATP binding site [chemical binding]; other site
383372007544	Q-loop/lid; other site
383372007545	ABC transporter signature motif; other site
383372007546	Walker B; other site
383372007547	D-loop; other site
383372007548	H-loop/switch region; other site
383372007549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372007550	dimer interface [polypeptide binding]; other site
383372007551	conserved gate region; other site
383372007552	putative PBP binding loops; other site
383372007553	ABC-ATPase subunit interface; other site
383372007554	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
383372007555	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
383372007556	phytoene desaturase; Region: crtI_fam; TIGR02734
383372007557	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
383372007558	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372007559	NAD(P) binding site [chemical binding]; other site
383372007560	active site
383372007561	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
383372007562	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
383372007563	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
383372007564	FtsX-like permease family; Region: FtsX; pfam02687
383372007565	TAP-like protein; Region: Abhydrolase_4; pfam08386
383372007566	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
383372007567	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
383372007568	active site
383372007569	catalytic residues [active]
383372007570	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
383372007571	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
383372007572	metal ion-dependent adhesion site (MIDAS); other site
383372007573	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372007574	phosphopeptide binding site; other site
383372007575	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372007576	ParB-like nuclease domain; Region: ParBc; pfam02195
383372007577	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
383372007578	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372007579	dimer interface [polypeptide binding]; other site
383372007580	putative PBP binding loops; other site
383372007581	ABC-ATPase subunit interface; other site
383372007582	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
383372007583	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372007584	dimer interface [polypeptide binding]; other site
383372007585	conserved gate region; other site
383372007586	putative PBP binding loops; other site
383372007587	ABC-ATPase subunit interface; other site
383372007588	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
383372007589	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
383372007590	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372007591	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372007592	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
383372007593	active site 2 [active]
383372007594	active site 1 [active]
383372007595	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
383372007596	CoA-transferase family III; Region: CoA_transf_3; pfam02515
383372007597	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
383372007598	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
383372007599	DNA-binding site [nucleotide binding]; DNA binding site
383372007600	FCD domain; Region: FCD; pfam07729
383372007601	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
383372007602	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
383372007603	putative active site pocket [active]
383372007604	metal binding site [ion binding]; metal-binding site
383372007605	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
383372007606	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
383372007607	OsmC-like protein; Region: OsmC; pfam02566
383372007608	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
383372007609	Beta-lactamase; Region: Beta-lactamase; pfam00144
383372007610	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
383372007611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372007612	Walker A motif; other site
383372007613	ATP binding site [chemical binding]; other site
383372007614	Walker B motif; other site
383372007615	arginine finger; other site
383372007616	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
383372007617	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
383372007618	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
383372007619	putative dimer interface [polypeptide binding]; other site
383372007620	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
383372007621	putative active site [active]
383372007622	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
383372007623	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
383372007624	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
383372007625	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372007626	S-adenosylmethionine binding site [chemical binding]; other site
383372007627	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
383372007628	RNA/DNA hybrid binding site [nucleotide binding]; other site
383372007629	active site
383372007630	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
383372007631	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
383372007632	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
383372007633	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
383372007634	substrate binding site [chemical binding]; other site
383372007635	ATP binding site [chemical binding]; other site
383372007636	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372007637	S-adenosylmethionine binding site [chemical binding]; other site
383372007638	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
383372007639	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372007640	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372007641	DNA binding residues [nucleotide binding]
383372007642	Putative zinc-finger; Region: zf-HC2; pfam13490
383372007643	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
383372007644	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372007645	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372007646	DNA binding residues [nucleotide binding]
383372007647	Putative zinc-finger; Region: zf-HC2; pfam13490
383372007648	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
383372007649	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
383372007650	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
383372007651	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
383372007652	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
383372007653	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
383372007654	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372007655	metal ion-dependent adhesion site (MIDAS); other site
383372007656	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
383372007657	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
383372007658	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372007659	metal ion-dependent adhesion site (MIDAS); other site
383372007660	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
383372007661	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
383372007662	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
383372007663	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372007664	S-adenosylmethionine binding site [chemical binding]; other site
383372007665	Major Facilitator Superfamily; Region: MFS_1; pfam07690
383372007666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372007667	putative substrate translocation pore; other site
383372007668	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
383372007669	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
383372007670	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
383372007671	transmembrane helices; other site
383372007672	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
383372007673	TrkA-C domain; Region: TrkA_C; pfam02080
383372007674	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
383372007675	TrkA-C domain; Region: TrkA_C; pfam02080
383372007676	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
383372007677	Predicted membrane protein [Function unknown]; Region: COG2510
383372007678	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
383372007679	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
383372007680	Domain interface; other site
383372007681	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
383372007682	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
383372007683	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
383372007684	Glucose dehydrogenase; Region: glucose_DH; cd08230
383372007685	NADP binding site [chemical binding]; other site
383372007686	catalytic Zn binding site [ion binding]; other site
383372007687	structural Zn binding site [ion binding]; other site
383372007688	dimer interface [polypeptide binding]; other site
383372007689	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372007690	Major Facilitator Superfamily; Region: MFS_1; pfam07690
383372007691	putative substrate translocation pore; other site
383372007692	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
383372007693	putative active site [active]
383372007694	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
383372007695	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
383372007696	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
383372007697	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372007698	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372007699	dimerization interface [polypeptide binding]; other site
383372007700	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372007701	dimer interface [polypeptide binding]; other site
383372007702	phosphorylation site [posttranslational modification]
383372007703	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372007704	ATP binding site [chemical binding]; other site
383372007705	Mg2+ binding site [ion binding]; other site
383372007706	G-X-G motif; other site
383372007707	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372007708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372007709	active site
383372007710	phosphorylation site [posttranslational modification]
383372007711	intermolecular recognition site; other site
383372007712	dimerization interface [polypeptide binding]; other site
383372007713	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372007714	DNA binding site [nucleotide binding]
383372007715	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372007716	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372007717	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372007718	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372007719	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372007720	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372007721	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
383372007722	MG2 domain; Region: A2M_N; pfam01835
383372007723	Alpha-2-macroglobulin family; Region: A2M; pfam00207
383372007724	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
383372007725	surface patch; other site
383372007726	thioester region; other site
383372007727	specificity defining residues; other site
383372007728	Transglycosylase; Region: Transgly; pfam00912
383372007729	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
383372007730	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
383372007731	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
383372007732	putative phosphoesterase; Region: acc_ester; TIGR03729
383372007733	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
383372007734	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
383372007735	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
383372007736	Flagellin N-methylase; Region: FliB; cl00497
383372007737	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372007738	TPR motif; other site
383372007739	binding surface
383372007740	Tetratricopeptide repeat; Region: TPR_9; pfam13371
383372007741	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372007742	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
383372007743	putative substrate translocation pore; other site
383372007744	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
383372007745	active site
383372007746	metal binding site [ion binding]; metal-binding site
383372007747	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372007748	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372007749	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372007750	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
383372007751	mannonate dehydratase; Region: uxuA; TIGR00695
383372007752	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
383372007753	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
383372007754	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372007755	NAD(P) binding site [chemical binding]; other site
383372007756	active site
383372007757	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
383372007758	xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631
383372007759	xylose isomerase; Provisional; Region: PRK12677
383372007760	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
383372007761	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
383372007762	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
383372007763	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
383372007764	N- and C-terminal domain interface [polypeptide binding]; other site
383372007765	D-xylulose kinase; Region: XylB; TIGR01312
383372007766	active site
383372007767	MgATP binding site [chemical binding]; other site
383372007768	catalytic site [active]
383372007769	metal binding site [ion binding]; metal-binding site
383372007770	xylulose binding site [chemical binding]; other site
383372007771	homodimer interface [polypeptide binding]; other site
383372007772	VanW like protein; Region: VanW; pfam04294
383372007773	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
383372007774	homotrimer interaction site [polypeptide binding]; other site
383372007775	putative active site [active]
383372007776	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
383372007777	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
383372007778	conserved cys residue [active]
383372007779	Uncharacterized conserved protein [Function unknown]; Region: COG5476
383372007780	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
383372007781	MlrC C-terminus; Region: MlrC_C; pfam07171
383372007782	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
383372007783	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
383372007784	inhibitor-cofactor binding pocket; inhibition site
383372007785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372007786	catalytic residue [active]
383372007787	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372007788	Cytochrome c; Region: Cytochrom_C; cl11414
383372007789	CopC domain; Region: CopC; pfam04234
383372007790	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
383372007791	CopC domain; Region: CopC; pfam04234
383372007792	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
383372007793	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
383372007794	active site
383372007795	Zn2+ binding site [ion binding]; other site
383372007796	intersubunit interface [polypeptide binding]; other site
383372007797	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372007798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372007799	putative active site [active]
383372007800	heme pocket [chemical binding]; other site
383372007801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372007802	dimer interface [polypeptide binding]; other site
383372007803	phosphorylation site [posttranslational modification]
383372007804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372007805	ATP binding site [chemical binding]; other site
383372007806	Mg2+ binding site [ion binding]; other site
383372007807	G-X-G motif; other site
383372007808	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
383372007809	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
383372007810	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
383372007811	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
383372007812	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
383372007813	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
383372007814	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
383372007815	4-alpha-glucanotransferase; Provisional; Region: PRK14508
383372007816	Small T antigen; Reviewed; Region: PHA03102
383372007817	enterobactin exporter EntS; Provisional; Region: PRK10489
383372007818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372007819	putative substrate translocation pore; other site
383372007820	Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856
383372007821	Uncharacterized conserved protein [Function unknown]; Region: COG3743
383372007822	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
383372007823	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
383372007824	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372007825	binding surface
383372007826	TPR motif; other site
383372007827	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
383372007828	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
383372007829	NAD binding site [chemical binding]; other site
383372007830	homodimer interface [polypeptide binding]; other site
383372007831	active site
383372007832	substrate binding site [chemical binding]; other site
383372007833	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
383372007834	CpXC protein; Region: CpXC; pfam14353
383372007835	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
383372007836	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
383372007837	dimer interface [polypeptide binding]; other site
383372007838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372007839	catalytic residue [active]
383372007840	TMAO/DMSO reductase; Reviewed; Region: PRK05363
383372007841	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
383372007842	Moco binding site; other site
383372007843	metal coordination site [ion binding]; other site
383372007844	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
383372007845	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
383372007846	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
383372007847	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
383372007848	Soluble P-type ATPase [General function prediction only]; Region: COG4087
383372007849	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
383372007850	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
383372007851	TrkA-N domain; Region: TrkA_N; pfam02254
383372007852	TrkA-C domain; Region: TrkA_C; pfam02080
383372007853	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
383372007854	TrkA-N domain; Region: TrkA_N; pfam02254
383372007855	TrkA-C domain; Region: TrkA_C; pfam02080
383372007856	PAS domain; Region: PAS; smart00091
383372007857	PAS fold; Region: PAS_4; pfam08448
383372007858	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372007859	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372007860	putative active site [active]
383372007861	heme pocket [chemical binding]; other site
383372007862	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372007863	dimer interface [polypeptide binding]; other site
383372007864	phosphorylation site [posttranslational modification]
383372007865	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372007866	ATP binding site [chemical binding]; other site
383372007867	Mg2+ binding site [ion binding]; other site
383372007868	G-X-G motif; other site
383372007869	Response regulator receiver domain; Region: Response_reg; pfam00072
383372007870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372007871	active site
383372007872	phosphorylation site [posttranslational modification]
383372007873	intermolecular recognition site; other site
383372007874	dimerization interface [polypeptide binding]; other site
383372007875	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
383372007876	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
383372007877	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372007878	putative active site [active]
383372007879	heme pocket [chemical binding]; other site
383372007880	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372007881	dimer interface [polypeptide binding]; other site
383372007882	phosphorylation site [posttranslational modification]
383372007883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372007884	ATP binding site [chemical binding]; other site
383372007885	Mg2+ binding site [ion binding]; other site
383372007886	G-X-G motif; other site
383372007887	Response regulator receiver domain; Region: Response_reg; pfam00072
383372007888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372007889	active site
383372007890	phosphorylation site [posttranslational modification]
383372007891	intermolecular recognition site; other site
383372007892	dimerization interface [polypeptide binding]; other site
383372007893	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
383372007894	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
383372007895	putative ligand binding site [chemical binding]; other site
383372007896	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
383372007897	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
383372007898	Walker A/P-loop; other site
383372007899	ATP binding site [chemical binding]; other site
383372007900	Q-loop/lid; other site
383372007901	ABC transporter signature motif; other site
383372007902	Walker B; other site
383372007903	D-loop; other site
383372007904	H-loop/switch region; other site
383372007905	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
383372007906	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
383372007907	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
383372007908	TM-ABC transporter signature motif; other site
383372007909	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
383372007910	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
383372007911	TM-ABC transporter signature motif; other site
383372007912	Cna protein B-type domain; Region: Cna_B_2; pfam13715
383372007913	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372007914	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372007915	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372007916	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
383372007917	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
383372007918	amidase catalytic site [active]
383372007919	Zn binding residues [ion binding]; other site
383372007920	substrate binding site [chemical binding]; other site
383372007921	WYL domain; Region: WYL; pfam13280
383372007922	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
383372007923	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
383372007924	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
383372007925	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372007926	metal ion-dependent adhesion site (MIDAS); other site
383372007927	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
383372007928	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
383372007929	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
383372007930	putative NTP binding site [chemical binding]; other site
383372007931	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
383372007932	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
383372007933	putative active site [active]
383372007934	putative nucleic acid binding site [nucleotide binding]; other site
383372007935	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
383372007936	RNA/DNA hybrid binding site [nucleotide binding]; other site
383372007937	active site
383372007938	CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766
383372007939	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
383372007940	WYL domain; Region: WYL; pfam13280
383372007941	CRISPR-associated protein (Cas_Cas02710); Region: Cas_Cas02710; pfam09670
383372007942	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09747
383372007943	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
383372007944	nucleoside/Zn binding site; other site
383372007945	dimer interface [polypeptide binding]; other site
383372007946	catalytic motif [active]
383372007947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372007948	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372007949	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
383372007950	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372007951	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
383372007952	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
383372007953	N-acetyl-D-glucosamine binding site [chemical binding]; other site
383372007954	catalytic residue [active]
383372007955	Protein of unknown function (DUF507); Region: DUF507; cl01112
383372007956	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
383372007957	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
383372007958	Metal-binding active site; metal-binding site
383372007959	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372007960	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372007961	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
383372007962	GIY-YIG motif/motif A; other site
383372007963	putative active site [active]
383372007964	putative metal binding site [ion binding]; other site
383372007965	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
383372007966	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
383372007967	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
383372007968	ABC transporter; Region: ABC_tran_2; pfam12848
383372007969	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
383372007970	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
383372007971	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372007972	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372007973	DNA binding residues [nucleotide binding]
383372007974	Putative zinc-finger; Region: zf-HC2; pfam13490
383372007975	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
383372007976	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
383372007977	Walker A/P-loop; other site
383372007978	ATP binding site [chemical binding]; other site
383372007979	Q-loop/lid; other site
383372007980	ABC transporter signature motif; other site
383372007981	Walker B; other site
383372007982	D-loop; other site
383372007983	H-loop/switch region; other site
383372007984	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
383372007985	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
383372007986	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
383372007987	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372007988	Coenzyme A binding pocket [chemical binding]; other site
383372007989	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
383372007990	primosomal protein N' Region: priA; TIGR00595
383372007991	ATP binding site [chemical binding]; other site
383372007992	putative Mg++ binding site [ion binding]; other site
383372007993	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
383372007994	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
383372007995	intersubunit interface [polypeptide binding]; other site
383372007996	active site
383372007997	catalytic residue [active]
383372007998	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
383372007999	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
383372008000	[2Fe-2S] cluster binding site [ion binding]; other site
383372008001	HlyD family secretion protein; Region: HlyD_3; pfam13437
383372008002	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
383372008003	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
383372008004	Walker A/P-loop; other site
383372008005	ATP binding site [chemical binding]; other site
383372008006	Q-loop/lid; other site
383372008007	ABC transporter signature motif; other site
383372008008	Walker B; other site
383372008009	D-loop; other site
383372008010	H-loop/switch region; other site
383372008011	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
383372008012	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
383372008013	ligand binding site [chemical binding]; other site
383372008014	flexible hinge region; other site
383372008015	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
383372008016	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
383372008017	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
383372008018	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
383372008019	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
383372008020	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
383372008021	putative substrate binding pocket [chemical binding]; other site
383372008022	dimer interface [polypeptide binding]; other site
383372008023	phosphate binding site [ion binding]; other site
383372008024	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372008025	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372008026	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
383372008027	substrate binding pocket [chemical binding]; other site
383372008028	substrate-Mg2+ binding site; other site
383372008029	aspartate-rich region 1; other site
383372008030	aspartate-rich region 2; other site
383372008031	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
383372008032	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
383372008033	Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635
383372008034	VirB8 protein; Region: VirB8; cl01500
383372008035	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425
383372008036	phosphate binding site [ion binding]; other site
383372008037	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
383372008038	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
383372008039	active site
383372008040	metal binding site [ion binding]; metal-binding site
383372008041	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
383372008042	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
383372008043	active site
383372008044	substrate binding site [chemical binding]; other site
383372008045	metal binding site [ion binding]; metal-binding site
383372008046	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
383372008047	O-Antigen ligase; Region: Wzy_C; pfam04932
383372008048	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372008049	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
383372008050	putative active site [active]
383372008051	heme pocket [chemical binding]; other site
383372008052	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372008053	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
383372008054	putative active site [active]
383372008055	heme pocket [chemical binding]; other site
383372008056	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372008057	dimer interface [polypeptide binding]; other site
383372008058	phosphorylation site [posttranslational modification]
383372008059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372008060	ATP binding site [chemical binding]; other site
383372008061	Mg2+ binding site [ion binding]; other site
383372008062	G-X-G motif; other site
383372008063	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372008064	Response regulator receiver domain; Region: Response_reg; pfam00072
383372008065	active site
383372008066	phosphorylation site [posttranslational modification]
383372008067	intermolecular recognition site; other site
383372008068	dimerization interface [polypeptide binding]; other site
383372008069	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
383372008070	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
383372008071	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372008072	binding surface
383372008073	TPR motif; other site
383372008074	TIGR01177 family protein; Region: TIGR01177
383372008075	Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407
383372008076	cyclase homology domain; Region: CHD; cd07302
383372008077	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
383372008078	nucleotidyl binding site; other site
383372008079	metal binding site [ion binding]; metal-binding site
383372008080	dimer interface [polypeptide binding]; other site
383372008081	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
383372008082	cyclase homology domain; Region: CHD; cd07302
383372008083	nucleotidyl binding site; other site
383372008084	metal binding site [ion binding]; metal-binding site
383372008085	dimer interface [polypeptide binding]; other site
383372008086	AAA ATPase domain; Region: AAA_16; pfam13191
383372008087	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372008088	TPR motif; other site
383372008089	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372008090	binding surface
383372008091	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372008092	binding surface
383372008093	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372008094	TPR motif; other site
383372008095	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372008096	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372008097	binding surface
383372008098	TPR motif; other site
383372008099	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372008100	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
383372008101	putative DNA binding site [nucleotide binding]; other site
383372008102	dimerization interface [polypeptide binding]; other site
383372008103	putative Zn2+ binding site [ion binding]; other site
383372008104	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
383372008105	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
383372008106	Walker A/P-loop; other site
383372008107	ATP binding site [chemical binding]; other site
383372008108	Q-loop/lid; other site
383372008109	ABC transporter signature motif; other site
383372008110	Walker B; other site
383372008111	D-loop; other site
383372008112	H-loop/switch region; other site
383372008113	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
383372008114	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
383372008115	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
383372008116	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
383372008117	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
383372008118	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
383372008119	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
383372008120	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
383372008121	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372008122	Methyltransferase domain; Region: Methyltransf_12; pfam08242
383372008123	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372008124	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372008125	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372008126	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372008127	Probable Catalytic site; other site
383372008128	metal-binding site
383372008129	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372008130	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372008131	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372008132	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372008133	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
383372008134	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
383372008135	active site
383372008136	metal binding site [ion binding]; metal-binding site
383372008137	homotetramer interface [polypeptide binding]; other site
383372008138	Major Facilitator Superfamily; Region: MFS_1; pfam07690
383372008139	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372008140	putative substrate translocation pore; other site
383372008141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372008142	putative substrate translocation pore; other site
383372008143	Major Facilitator Superfamily; Region: MFS_1; pfam07690
383372008144	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
383372008145	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
383372008146	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
383372008147	metal binding site [ion binding]; metal-binding site
383372008148	active site
383372008149	I-site; other site
383372008150	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372008151	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372008152	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372008153	Family description; Region: VCBS; pfam13517
383372008154	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
383372008155	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
383372008156	nucleotide binding site [chemical binding]; other site
383372008157	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372008158	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372008159	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372008160	hypothetical protein; Provisional; Region: PRK02947
383372008161	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
383372008162	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
383372008163	putative active site [active]
383372008164	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
383372008165	classical (c) SDRs; Region: SDR_c; cd05233
383372008166	NAD(P) binding site [chemical binding]; other site
383372008167	active site
383372008168	methionine synthase; Provisional; Region: PRK01207
383372008169	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
383372008170	substrate binding site [chemical binding]; other site
383372008171	THF binding site; other site
383372008172	zinc-binding site [ion binding]; other site
383372008173	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
383372008174	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
383372008175	EamA-like transporter family; Region: EamA; pfam00892
383372008176	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
383372008177	metal ion-dependent adhesion site (MIDAS); other site
383372008178	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
383372008179	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
383372008180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372008181	catalytic residue [active]
383372008182	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
383372008183	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
383372008184	minor groove reading motif; other site
383372008185	helix-hairpin-helix signature motif; other site
383372008186	substrate binding pocket [chemical binding]; other site
383372008187	active site
383372008188	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
383372008189	magnesium chelatase, H subunit; Region: BchH; TIGR02025
383372008190	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
383372008191	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
383372008192	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
383372008193	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
383372008194	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
383372008195	putative acyl-acceptor binding pocket; other site
383372008196	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
383372008197	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
383372008198	Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481
383372008199	active site
383372008200	catalytic triad [active]
383372008201	Cna protein B-type domain; Region: Cna_B_2; pfam13715
383372008202	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
383372008203	generic binding surface I; other site
383372008204	generic binding surface II; other site
383372008205	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
383372008206	putative active site [active]
383372008207	putative catalytic site [active]
383372008208	putative Mg binding site IVb [ion binding]; other site
383372008209	putative phosphate binding site [ion binding]; other site
383372008210	putative DNA binding site [nucleotide binding]; other site
383372008211	putative Mg binding site IVa [ion binding]; other site
383372008212	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
383372008213	Protein of unknown function (DUF433); Region: DUF433; pfam04255
383372008214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
383372008215	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
383372008216	oligomerisation interface [polypeptide binding]; other site
383372008217	mobile loop; other site
383372008218	roof hairpin; other site
383372008219	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
383372008220	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
383372008221	ring oligomerisation interface [polypeptide binding]; other site
383372008222	ATP/Mg binding site [chemical binding]; other site
383372008223	stacking interactions; other site
383372008224	hinge regions; other site
383372008225	Cytochrome c; Region: Cytochrom_C; pfam00034
383372008226	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372008227	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372008228	dimerization interface [polypeptide binding]; other site
383372008229	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372008230	dimer interface [polypeptide binding]; other site
383372008231	phosphorylation site [posttranslational modification]
383372008232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372008233	ATP binding site [chemical binding]; other site
383372008234	Mg2+ binding site [ion binding]; other site
383372008235	G-X-G motif; other site
383372008236	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372008237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372008238	active site
383372008239	phosphorylation site [posttranslational modification]
383372008240	intermolecular recognition site; other site
383372008241	dimerization interface [polypeptide binding]; other site
383372008242	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372008243	DNA binding site [nucleotide binding]
383372008244	Domain of unknown function (DUF305); Region: DUF305; pfam03713
383372008245	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372008246	putative active site [active]
383372008247	Protein of unknown function (DUF507); Region: DUF507; cl01112
383372008248	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
383372008249	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
383372008250	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
383372008251	glycogen synthase; Provisional; Region: glgA; PRK00654
383372008252	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
383372008253	ADP-binding pocket [chemical binding]; other site
383372008254	homodimer interface [polypeptide binding]; other site
383372008255	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
383372008256	PAS domain; Region: PAS; smart00091
383372008257	PAS fold; Region: PAS_4; pfam08448
383372008258	putative active site [active]
383372008259	heme pocket [chemical binding]; other site
383372008260	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372008261	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
383372008262	intersubunit interface [polypeptide binding]; other site
383372008263	active site
383372008264	catalytic residue [active]
383372008265	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372008266	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372008267	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372008268	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
383372008269	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
383372008270	Metal-binding active site; metal-binding site
383372008271	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
383372008272	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
383372008273	Moco binding site; other site
383372008274	metal coordination site [ion binding]; other site
383372008275	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372008276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372008277	active site
383372008278	phosphorylation site [posttranslational modification]
383372008279	intermolecular recognition site; other site
383372008280	dimerization interface [polypeptide binding]; other site
383372008281	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372008282	DNA binding site [nucleotide binding]
383372008283	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
383372008284	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
383372008285	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372008286	homodimer interface [polypeptide binding]; other site
383372008287	catalytic residue [active]
383372008288	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
383372008289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372008290	S-adenosylmethionine binding site [chemical binding]; other site
383372008291	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
383372008292	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
383372008293	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
383372008294	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
383372008295	protein binding site [polypeptide binding]; other site
383372008296	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
383372008297	Domain interface; other site
383372008298	Peptide binding site; other site
383372008299	Active site tetrad [active]
383372008300	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
383372008301	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
383372008302	peptide binding site [polypeptide binding]; other site
383372008303	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
383372008304	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372008305	dimer interface [polypeptide binding]; other site
383372008306	conserved gate region; other site
383372008307	putative PBP binding loops; other site
383372008308	ABC-ATPase subunit interface; other site
383372008309	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
383372008310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372008311	dimer interface [polypeptide binding]; other site
383372008312	conserved gate region; other site
383372008313	putative PBP binding loops; other site
383372008314	ABC-ATPase subunit interface; other site
383372008315	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
383372008316	dimerization interface [polypeptide binding]; other site
383372008317	putative DNA binding site [nucleotide binding]; other site
383372008318	putative Zn2+ binding site [ion binding]; other site
383372008319	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589
383372008320	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
383372008321	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
383372008322	E3 interaction surface; other site
383372008323	lipoyl attachment site [posttranslational modification]; other site
383372008324	e3 binding domain; Region: E3_binding; pfam02817
383372008325	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
383372008326	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372008327	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372008328	active site
383372008329	ATP binding site [chemical binding]; other site
383372008330	substrate binding site [chemical binding]; other site
383372008331	activation loop (A-loop); other site
383372008332	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372008333	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372008334	phosphopeptide binding site; other site
383372008335	putative active site [active]
383372008336	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
383372008337	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372008338	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372008339	phosphopeptide binding site; other site
383372008340	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
383372008341	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
383372008342	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
383372008343	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372008344	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372008345	phosphopeptide binding site; other site
383372008346	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
383372008347	Calx-beta domain; Region: Calx-beta; cl02522
383372008348	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372008349	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372008350	active site
383372008351	ATP binding site [chemical binding]; other site
383372008352	substrate binding site [chemical binding]; other site
383372008353	activation loop (A-loop); other site
383372008354	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372008355	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372008356	phosphopeptide binding site; other site
383372008357	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372008358	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372008359	active site
383372008360	ATP binding site [chemical binding]; other site
383372008361	substrate binding site [chemical binding]; other site
383372008362	activation loop (A-loop); other site
383372008363	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372008364	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372008365	phosphopeptide binding site; other site
383372008366	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
383372008367	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
383372008368	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372008369	active site
383372008370	ATP binding site [chemical binding]; other site
383372008371	substrate binding site [chemical binding]; other site
383372008372	activation loop (A-loop); other site
383372008373	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372008374	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372008375	phosphopeptide binding site; other site
383372008376	Methyltransferase domain; Region: Methyltransf_31; pfam13847
383372008377	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372008378	S-adenosylmethionine binding site [chemical binding]; other site
383372008379	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
383372008380	Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797
383372008381	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372008382	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372008383	phosphopeptide binding site; other site
383372008384	phage tail protein domain; Region: tail_TIGR02242
383372008385	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
383372008386	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
383372008387	PAAR motif; Region: PAAR_motif; pfam05488
383372008388	Phage protein D [General function prediction only]; Region: COG3500
383372008389	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
383372008390	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
383372008391	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
383372008392	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
383372008393	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
383372008394	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
383372008395	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
383372008396	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
383372008397	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372008398	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
383372008399	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
383372008400	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
383372008401	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
383372008402	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
383372008403	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
383372008404	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372008405	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
383372008406	Walker A motif; other site
383372008407	ATP binding site [chemical binding]; other site
383372008408	Walker B motif; other site
383372008409	arginine finger; other site
383372008410	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
383372008411	Right handed beta helix region; Region: Beta_helix; pfam13229
383372008412	RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025
383372008413	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
383372008414	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
383372008415	DNA binding residues [nucleotide binding]
383372008416	putative dimer interface [polypeptide binding]; other site
383372008417	chaperone protein DnaJ; Provisional; Region: PRK14299
383372008418	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
383372008419	HSP70 interaction site [polypeptide binding]; other site
383372008420	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
383372008421	substrate binding site [polypeptide binding]; other site
383372008422	dimer interface [polypeptide binding]; other site
383372008423	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
383372008424	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
383372008425	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
383372008426	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372008427	dimer interface [polypeptide binding]; other site
383372008428	conserved gate region; other site
383372008429	putative PBP binding loops; other site
383372008430	ABC-ATPase subunit interface; other site
383372008431	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
383372008432	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372008433	dimer interface [polypeptide binding]; other site
383372008434	conserved gate region; other site
383372008435	putative PBP binding loops; other site
383372008436	ABC-ATPase subunit interface; other site
383372008437	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
383372008438	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
383372008439	Walker A/P-loop; other site
383372008440	ATP binding site [chemical binding]; other site
383372008441	Q-loop/lid; other site
383372008442	ABC transporter signature motif; other site
383372008443	Walker B; other site
383372008444	D-loop; other site
383372008445	H-loop/switch region; other site
383372008446	TOBE domain; Region: TOBE_2; pfam08402
383372008447	CARDB; Region: CARDB; pfam07705
383372008448	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
383372008449	camphor resistance protein CrcB; Provisional; Region: PRK14215
383372008450	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
383372008451	FOG: CBS domain [General function prediction only]; Region: COG0517
383372008452	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
383372008453	FOG: CBS domain [General function prediction only]; Region: COG0517
383372008454	FOG: CBS domain [General function prediction only]; Region: COG0517
383372008455	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
383372008456	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
383372008457	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372008458	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372008459	Walker A/P-loop; other site
383372008460	Walker A/P-loop; other site
383372008461	ATP binding site [chemical binding]; other site
383372008462	ATP binding site [chemical binding]; other site
383372008463	Q-loop/lid; other site
383372008464	Q-loop/lid; other site
383372008465	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
383372008466	ABC transporter signature motif; other site
383372008467	Walker B; other site
383372008468	D-loop; other site
383372008469	ABC transporter; Region: ABC_tran_2; pfam12848
383372008470	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
383372008471	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
383372008472	active site
383372008473	substrate-binding site [chemical binding]; other site
383372008474	metal-binding site [ion binding]
383372008475	GTP binding site [chemical binding]; other site
383372008476	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372008477	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372008478	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372008479	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
383372008480	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
383372008481	GAF domain; Region: GAF; pfam01590
383372008482	GAF domain; Region: GAF_2; pfam13185
383372008483	GAF domain; Region: GAF_3; pfam13492
383372008484	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372008485	GAF domain; Region: GAF; pfam01590
383372008486	GAF domain; Region: GAF_2; pfam13185
383372008487	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372008488	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372008489	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
383372008490	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
383372008491	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
383372008492	active site
383372008493	catalytic site [active]
383372008494	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
383372008495	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
383372008496	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
383372008497	active site
383372008498	metal binding site [ion binding]; metal-binding site
383372008499	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
383372008500	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
383372008501	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
383372008502	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
383372008503	protein binding site [polypeptide binding]; other site
383372008504	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
383372008505	Domain interface; other site
383372008506	Peptide binding site; other site
383372008507	Active site tetrad [active]
383372008508	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
383372008509	active site
383372008510	ribulose/triose binding site [chemical binding]; other site
383372008511	phosphate binding site [ion binding]; other site
383372008512	substrate (anthranilate) binding pocket [chemical binding]; other site
383372008513	product (indole) binding pocket [chemical binding]; other site
383372008514	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
383372008515	amidase; Provisional; Region: PRK07486
383372008516	Amidase; Region: Amidase; pfam01425
383372008517	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
383372008518	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
383372008519	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
383372008520	active site
383372008521	Int/Topo IB signature motif; other site
383372008522	DNA binding site [nucleotide binding]
383372008523	PemK-like protein; Region: PemK; pfam02452
383372008524	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
383372008525	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
383372008526	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
383372008527	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372008528	active site
383372008529	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
383372008530	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
383372008531	active site
383372008532	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
383372008533	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
383372008534	active site
383372008535	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
383372008536	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
383372008537	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
383372008538	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
383372008539	active site
383372008540	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
383372008541	putative NADP binding site [chemical binding]; other site
383372008542	active site
383372008543	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
383372008544	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
383372008545	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
383372008546	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
383372008547	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
383372008548	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
383372008549	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
383372008550	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
383372008551	ATP-grasp domain; Region: ATP-grasp_4; cl17255
383372008552	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
383372008553	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
383372008554	carboxyltransferase (CT) interaction site; other site
383372008555	biotinylation site [posttranslational modification]; other site
383372008556	YcfA-like protein; Region: YcfA; pfam07927
383372008557	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
383372008558	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
383372008559	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372008560	putative active site [active]
383372008561	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
383372008562	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372008563	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
383372008564	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372008565	DNA binding residues [nucleotide binding]
383372008566	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
383372008567	Protein of unknown function DUF58; Region: DUF58; pfam01882
383372008568	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
383372008569	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
383372008570	trmE is a tRNA modification GTPase; Region: trmE; cd04164
383372008571	G1 box; other site
383372008572	GTP/Mg2+ binding site [chemical binding]; other site
383372008573	Switch I region; other site
383372008574	G2 box; other site
383372008575	Switch II region; other site
383372008576	G3 box; other site
383372008577	G4 box; other site
383372008578	G5 box; other site
383372008579	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
383372008580	Response regulator receiver domain; Region: Response_reg; pfam00072
383372008581	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372008582	active site
383372008583	phosphorylation site [posttranslational modification]
383372008584	intermolecular recognition site; other site
383372008585	dimerization interface [polypeptide binding]; other site
383372008586	Helix-turn-helix domain; Region: HTH_25; pfam13413
383372008587	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
383372008588	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
383372008589	Protein of unknown function (DUF3623); Region: DUF3623; cl11843
383372008590	PUCC protein; Region: PUCC; pfam03209
383372008591	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
383372008592	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
383372008593	ligand binding site [chemical binding]; other site
383372008594	flexible hinge region; other site
383372008595	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
383372008596	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
383372008597	ligand binding site [chemical binding]; other site
383372008598	flexible hinge region; other site
383372008599	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
383372008600	4Fe-4S binding domain; Region: Fer4; pfam00037
383372008601	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
383372008602	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
383372008603	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
383372008604	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
383372008605	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
383372008606	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
383372008607	nucleotide binding site [chemical binding]; other site
383372008608	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
383372008609	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
383372008610	dimer interface [polypeptide binding]; other site
383372008611	active site
383372008612	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
383372008613	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
383372008614	carboxyltransferase (CT) interaction site; other site
383372008615	biotinylation site [posttranslational modification]; other site
383372008616	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
383372008617	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
383372008618	generic binding surface II; other site
383372008619	generic binding surface I; other site
383372008620	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
383372008621	Membrane transport protein; Region: Mem_trans; cl09117
383372008622	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372008623	S-adenosylmethionine binding site [chemical binding]; other site
383372008624	YGGT family; Region: YGGT; pfam02325
383372008625	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
383372008626	histidinol dehydrogenase; Region: hisD; TIGR00069
383372008627	NAD binding site [chemical binding]; other site
383372008628	dimerization interface [polypeptide binding]; other site
383372008629	product binding site; other site
383372008630	substrate binding site [chemical binding]; other site
383372008631	zinc binding site [ion binding]; other site
383372008632	catalytic residues [active]
383372008633	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
383372008634	ATP phosphoribosyltransferase; Region: HisG; cl15266
383372008635	HisG, C-terminal domain; Region: HisG_C; cl06867
383372008636	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372008637	putative active site [active]
383372008638	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372008639	putative active site [active]
383372008640	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
383372008641	Protein of unknown function DUF58; Region: DUF58; pfam01882
383372008642	MoxR-like ATPases [General function prediction only]; Region: COG0714
383372008643	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372008644	Walker A motif; other site
383372008645	ATP binding site [chemical binding]; other site
383372008646	Walker B motif; other site
383372008647	arginine finger; other site
383372008648	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
383372008649	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
383372008650	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
383372008651	motif 1; other site
383372008652	dimer interface [polypeptide binding]; other site
383372008653	motif 2; other site
383372008654	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
383372008655	motif 3; other site
383372008656	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
383372008657	anticodon binding site; other site
383372008658	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372008659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372008660	ATP binding site [chemical binding]; other site
383372008661	Mg2+ binding site [ion binding]; other site
383372008662	G-X-G motif; other site
383372008663	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
383372008664	endonuclease III; Region: ENDO3c; smart00478
383372008665	minor groove reading motif; other site
383372008666	helix-hairpin-helix signature motif; other site
383372008667	substrate binding pocket [chemical binding]; other site
383372008668	active site
383372008669	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
383372008670	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
383372008671	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
383372008672	active site
383372008673	Zn binding site [ion binding]; other site
383372008674	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
383372008675	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
383372008676	putative active site [active]
383372008677	oxyanion strand; other site
383372008678	catalytic triad [active]
383372008679	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
383372008680	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
383372008681	catalytic residues [active]
383372008682	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
383372008683	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
383372008684	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
383372008685	substrate binding site [chemical binding]; other site
383372008686	glutamase interaction surface [polypeptide binding]; other site
383372008687	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
383372008688	MoaE interaction surface [polypeptide binding]; other site
383372008689	MoeB interaction surface [polypeptide binding]; other site
383372008690	thiocarboxylated glycine; other site
383372008691	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
383372008692	MoaE homodimer interface [polypeptide binding]; other site
383372008693	MoaD interaction [polypeptide binding]; other site
383372008694	active site residues [active]
383372008695	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
383372008696	Domain of unknown function DUF21; Region: DUF21; pfam01595
383372008697	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
383372008698	Transporter associated domain; Region: CorC_HlyC; smart01091
383372008699	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
383372008700	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
383372008701	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
383372008702	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
383372008703	classical (c) SDRs; Region: SDR_c; cd05233
383372008704	NAD(P) binding site [chemical binding]; other site
383372008705	active site
383372008706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372008707	NAD(P) binding site [chemical binding]; other site
383372008708	active site
383372008709	classical (c) SDRs; Region: SDR_c; cd05233
383372008710	NAD(P) binding site [chemical binding]; other site
383372008711	active site
383372008712	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
383372008713	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
383372008714	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
383372008715	acyl-activating enzyme (AAE) consensus motif; other site
383372008716	AMP binding site [chemical binding]; other site
383372008717	active site
383372008718	CoA binding site [chemical binding]; other site
383372008719	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
383372008720	substrate binding site [chemical binding]; other site
383372008721	oxyanion hole (OAH) forming residues; other site
383372008722	trimer interface [polypeptide binding]; other site
383372008723	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
383372008724	NAD(P) binding site [chemical binding]; other site
383372008725	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
383372008726	NAD(P) binding site [chemical binding]; other site
383372008727	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
383372008728	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
383372008729	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
383372008730	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
383372008731	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
383372008732	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
383372008733	NAD(P) binding site [chemical binding]; other site
383372008734	catalytic residues [active]
383372008735	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
383372008736	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
383372008737	NADP binding site [chemical binding]; other site
383372008738	dimer interface [polypeptide binding]; other site
383372008739	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
383372008740	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
383372008741	protein binding site [polypeptide binding]; other site
383372008742	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
383372008743	Domain interface; other site
383372008744	Peptide binding site; other site
383372008745	Active site tetrad [active]
383372008746	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
383372008747	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
383372008748	intersubunit interface [polypeptide binding]; other site
383372008749	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
383372008750	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
383372008751	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
383372008752	cobalamin binding residues [chemical binding]; other site
383372008753	putative BtuC binding residues; other site
383372008754	dimer interface [polypeptide binding]; other site
383372008755	chaperone protein DnaJ; Provisional; Region: PRK10767
383372008756	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
383372008757	HSP70 interaction site [polypeptide binding]; other site
383372008758	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
383372008759	substrate binding site [polypeptide binding]; other site
383372008760	dimer interface [polypeptide binding]; other site
383372008761	hypothetical protein; Validated; Region: PRK06840
383372008762	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
383372008763	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
383372008764	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
383372008765	active site
383372008766	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
383372008767	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
383372008768	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
383372008769	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
383372008770	catalytic residues [active]
383372008771	dimer interface [polypeptide binding]; other site
383372008772	Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
383372008773	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
383372008774	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
383372008775	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
383372008776	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
383372008777	G8 domain; Region: G8; pfam10162
383372008778	Right handed beta helix region; Region: Beta_helix; pfam13229
383372008779	Protein of unknown function (DUF497); Region: DUF497; pfam04365
383372008780	oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108
383372008781	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
383372008782	active site
383372008783	catalytic residues [active]
383372008784	metal binding site [ion binding]; metal-binding site
383372008785	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
383372008786	carboxyltransferase (CT) interaction site; other site
383372008787	biotinylation site [posttranslational modification]; other site
383372008788	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
383372008789	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
383372008790	ATP-grasp domain; Region: ATP-grasp_4; cl17255
383372008791	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
383372008792	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
383372008793	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
383372008794	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372008795	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
383372008796	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372008797	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
383372008798	active site
383372008799	catalytic site [active]
383372008800	recombinase A; Provisional; Region: recA; PRK09354
383372008801	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
383372008802	hexamer interface [polypeptide binding]; other site
383372008803	Walker A motif; other site
383372008804	ATP binding site [chemical binding]; other site
383372008805	Walker B motif; other site
383372008806	RecX family; Region: RecX; cl00936
383372008807	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
383372008808	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
383372008809	CTP synthetase; Validated; Region: pyrG; PRK05380
383372008810	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
383372008811	Catalytic site [active]
383372008812	active site
383372008813	UTP binding site [chemical binding]; other site
383372008814	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
383372008815	active site
383372008816	putative oxyanion hole; other site
383372008817	catalytic triad [active]
383372008818	hypothetical protein; Provisional; Region: PRK11770
383372008819	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
383372008820	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
383372008821	4-alpha-glucanotransferase; Provisional; Region: PRK14508
383372008822	Domain of unknown function DUF11; Region: DUF11; pfam01345
383372008823	Domain of unknown function DUF11; Region: DUF11; cl17728
383372008824	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
383372008825	cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976
383372008826	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
383372008827	catalytic residue [active]
383372008828	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
383372008829	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372008830	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
383372008831	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372008832	DNA binding residues [nucleotide binding]
383372008833	O-Antigen ligase; Region: Wzy_C; pfam04932
383372008834	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
383372008835	binding surface
383372008836	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
383372008837	putative active site [active]
383372008838	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
383372008839	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
383372008840	GIY-YIG motif/motif A; other site
383372008841	active site
383372008842	catalytic site [active]
383372008843	putative DNA binding site [nucleotide binding]; other site
383372008844	metal binding site [ion binding]; metal-binding site
383372008845	UvrB/uvrC motif; Region: UVR; pfam02151
383372008846	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
383372008847	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
383372008848	DNA binding site [nucleotide binding]
383372008849	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
383372008850	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
383372008851	tetramer (dimer of dimers) interface [polypeptide binding]; other site
383372008852	active site
383372008853	dimer interface [polypeptide binding]; other site
383372008854	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
383372008855	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
383372008856	Cu(I) binding site [ion binding]; other site
383372008857	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
383372008858	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
383372008859	catalytic loop [active]
383372008860	iron binding site [ion binding]; other site
383372008861	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
383372008862	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
383372008863	ATP binding site [chemical binding]; other site
383372008864	putative Mg++ binding site [ion binding]; other site
383372008865	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
383372008866	nucleotide binding region [chemical binding]; other site
383372008867	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
383372008868	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
383372008869	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
383372008870	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372008871	motif II; other site
383372008872	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
383372008873	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
383372008874	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
383372008875	adhesin; Provisional; Region: PRK09752
383372008876	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
383372008877	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
383372008878	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
383372008879	catalytic residues [active]
383372008880	prolyl-tRNA synthetase, family II; Region: proS_fam_II; TIGR00409
383372008881	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
383372008882	motif 1; other site
383372008883	dimer interface [polypeptide binding]; other site
383372008884	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
383372008885	putative deacylase active site [active]
383372008886	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
383372008887	anticodon binding site; other site
383372008888	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
383372008889	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372008890	S-adenosylmethionine binding site [chemical binding]; other site
383372008891	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
383372008892	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
383372008893	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
383372008894	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
383372008895	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
383372008896	prephenate dehydrogenase; Validated; Region: PRK08507
383372008897	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
383372008898	B12 binding site [chemical binding]; other site
383372008899	cobalt ligand [ion binding]; other site
383372008900	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
383372008901	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
383372008902	Walker A; other site
383372008903	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
383372008904	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
383372008905	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
383372008906	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372008907	homodimer interface [polypeptide binding]; other site
383372008908	catalytic residue [active]
383372008909	GAF domain; Region: GAF_2; pfam13185
383372008910	GAF domain; Region: GAF; pfam01590
383372008911	PAS fold; Region: PAS_4; pfam08448
383372008912	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372008913	putative active site [active]
383372008914	heme pocket [chemical binding]; other site
383372008915	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372008916	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372008917	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372008918	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372008919	putative active site [active]
383372008920	heme pocket [chemical binding]; other site
383372008921	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
383372008922	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372008923	ATP binding site [chemical binding]; other site
383372008924	Mg2+ binding site [ion binding]; other site
383372008925	G-X-G motif; other site
383372008926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372008927	Response regulator receiver domain; Region: Response_reg; pfam00072
383372008928	active site
383372008929	phosphorylation site [posttranslational modification]
383372008930	intermolecular recognition site; other site
383372008931	dimerization interface [polypeptide binding]; other site
383372008932	Predicted methyltransferases [General function prediction only]; Region: COG0313
383372008933	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
383372008934	putative SAM binding site [chemical binding]; other site
383372008935	putative homodimer interface [polypeptide binding]; other site
383372008936	aspartate kinase; Provisional; Region: PRK06291
383372008937	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
383372008938	nucleotide binding site [chemical binding]; other site
383372008939	substrate binding site [chemical binding]; other site
383372008940	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
383372008941	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
383372008942	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
383372008943	FAD binding site [chemical binding]; other site
383372008944	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
383372008945	Ligand Binding Site [chemical binding]; other site
383372008946	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
383372008947	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
383372008948	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
383372008949	active site
383372008950	HIGH motif; other site
383372008951	KMSKS motif; other site
383372008952	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
383372008953	tRNA binding surface [nucleotide binding]; other site
383372008954	anticodon binding site; other site
383372008955	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372008956	active site
383372008957	NTP binding site [chemical binding]; other site
383372008958	metal binding triad [ion binding]; metal-binding site
383372008959	antibiotic binding site [chemical binding]; other site
383372008960	Uncharacterized conserved protein [Function unknown]; Region: COG2445
383372008961	Cupin domain; Region: Cupin_2; cl17218
383372008962	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
383372008963	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
383372008964	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
383372008965	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
383372008966	Ligand Binding Site [chemical binding]; other site
383372008967	Molecular Tunnel; other site
383372008968	hypothetical protein; Validated; Region: PRK06201
383372008969	hypothetical protein; Validated; Region: PRK08245
383372008970	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
383372008971	Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950
383372008972	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
383372008973	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
383372008974	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
383372008975	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
383372008976	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
383372008977	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
383372008978	dimerization interface [polypeptide binding]; other site
383372008979	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372008980	dimer interface [polypeptide binding]; other site
383372008981	phosphorylation site [posttranslational modification]
383372008982	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372008983	ATP binding site [chemical binding]; other site
383372008984	Mg2+ binding site [ion binding]; other site
383372008985	G-X-G motif; other site
383372008986	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
383372008987	transmembrane helices; other site
383372008988	TrkA-C domain; Region: TrkA_C; pfam02080
383372008989	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
383372008990	TrkA-C domain; Region: TrkA_C; pfam02080
383372008991	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
383372008992	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
383372008993	active site
383372008994	metal binding site [ion binding]; metal-binding site
383372008995	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
383372008996	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
383372008997	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
383372008998	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
383372008999	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372009000	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372009001	active site
383372009002	ATP binding site [chemical binding]; other site
383372009003	substrate binding site [chemical binding]; other site
383372009004	activation loop (A-loop); other site
383372009005	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
383372009006	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
383372009007	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
383372009008	RNase_H superfamily; Region: RNase_H_2; pfam13482
383372009009	active site
383372009010	substrate binding site [chemical binding]; other site
383372009011	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
383372009012	active site
383372009013	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
383372009014	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
383372009015	Walker A/P-loop; other site
383372009016	ATP binding site [chemical binding]; other site
383372009017	Q-loop/lid; other site
383372009018	ABC transporter signature motif; other site
383372009019	Walker B; other site
383372009020	D-loop; other site
383372009021	H-loop/switch region; other site
383372009022	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
383372009023	HSP70 interaction site [polypeptide binding]; other site
383372009024	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
383372009025	Double zinc ribbon; Region: DZR; pfam12773
383372009026	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372009027	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372009028	phosphopeptide binding site; other site
383372009029	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
383372009030	dimer interface [polypeptide binding]; other site
383372009031	ADP-ribose binding site [chemical binding]; other site
383372009032	active site
383372009033	nudix motif; other site
383372009034	metal binding site [ion binding]; metal-binding site
383372009035	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
383372009036	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
383372009037	catalytic triad [active]
383372009038	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372009039	Coenzyme A binding pocket [chemical binding]; other site
383372009040	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
383372009041	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
383372009042	active site
383372009043	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
383372009044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372009045	Walker A motif; other site
383372009046	ATP binding site [chemical binding]; other site
383372009047	Walker B motif; other site
383372009048	arginine finger; other site
383372009049	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
383372009050	methionine sulfoxide reductase B; Provisional; Region: PRK00222
383372009051	SelR domain; Region: SelR; pfam01641
383372009052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372009053	S-adenosylmethionine binding site [chemical binding]; other site
383372009054	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372009055	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372009056	S-adenosylmethionine binding site [chemical binding]; other site
383372009057	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
383372009058	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
383372009059	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
383372009060	Walker A/P-loop; other site
383372009061	ATP binding site [chemical binding]; other site
383372009062	Q-loop/lid; other site
383372009063	ABC transporter signature motif; other site
383372009064	Walker B; other site
383372009065	D-loop; other site
383372009066	H-loop/switch region; other site
383372009067	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
383372009068	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
383372009069	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
383372009070	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
383372009071	alpha subunit interface [polypeptide binding]; other site
383372009072	TPP binding site [chemical binding]; other site
383372009073	heterodimer interface [polypeptide binding]; other site
383372009074	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
383372009075	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
383372009076	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
383372009077	tetramer interface [polypeptide binding]; other site
383372009078	TPP-binding site [chemical binding]; other site
383372009079	heterodimer interface [polypeptide binding]; other site
383372009080	phosphorylation loop region [posttranslational modification]
383372009081	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372009082	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372009083	Histidine kinase; Region: HisKA_3; pfam07730
383372009084	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
383372009085	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372009086	ATP binding site [chemical binding]; other site
383372009087	Mg2+ binding site [ion binding]; other site
383372009088	G-X-G motif; other site
383372009089	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
383372009090	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
383372009091	short chain dehydrogenase; Provisional; Region: PRK06181
383372009092	classical (c) SDRs; Region: SDR_c; cd05233
383372009093	NAD(P) binding site [chemical binding]; other site
383372009094	active site
383372009095	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
383372009096	30S subunit binding site; other site
383372009097	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
383372009098	putative ligand binding pocket/active site [active]
383372009099	putative metal binding site [ion binding]; other site
383372009100	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
383372009101	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
383372009102	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
383372009103	oligomer interface [polypeptide binding]; other site
383372009104	metal binding site [ion binding]; metal-binding site
383372009105	metal binding site [ion binding]; metal-binding site
383372009106	putative Cl binding site [ion binding]; other site
383372009107	aspartate ring; other site
383372009108	basic sphincter; other site
383372009109	hydrophobic gate; other site
383372009110	periplasmic entrance; other site
383372009111	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
383372009112	TrkA-N domain; Region: TrkA_N; pfam02254
383372009113	TrkA-C domain; Region: TrkA_C; pfam02080
383372009114	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
383372009115	TrkA-N domain; Region: TrkA_N; pfam02254
383372009116	TrkA-C domain; Region: TrkA_C; pfam02080
383372009117	ornithine carbamoyltransferase; Provisional; Region: PRK00779
383372009118	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
383372009119	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
383372009120	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
383372009121	argininosuccinate lyase; Provisional; Region: PRK00855
383372009122	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
383372009123	active sites [active]
383372009124	tetramer interface [polypeptide binding]; other site
383372009125	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372009126	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372009127	putative active site [active]
383372009128	heme pocket [chemical binding]; other site
383372009129	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372009130	dimer interface [polypeptide binding]; other site
383372009131	phosphorylation site [posttranslational modification]
383372009132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372009133	ATP binding site [chemical binding]; other site
383372009134	Mg2+ binding site [ion binding]; other site
383372009135	G-X-G motif; other site
383372009136	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
383372009137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009138	active site
383372009139	phosphorylation site [posttranslational modification]
383372009140	intermolecular recognition site; other site
383372009141	dimerization interface [polypeptide binding]; other site
383372009142	Low molecular weight phosphatase family; Region: LMWPc; cl00105
383372009143	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
383372009144	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
383372009145	putative Iron-sulfur protein interface [polypeptide binding]; other site
383372009146	proximal heme binding site [chemical binding]; other site
383372009147	distal heme binding site [chemical binding]; other site
383372009148	putative dimer interface [polypeptide binding]; other site
383372009149	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
383372009150	L-aspartate oxidase; Provisional; Region: PRK06175
383372009151	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
383372009152	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
383372009153	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
383372009154	Methyltransferase domain; Region: Methyltransf_26; pfam13659
383372009155	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
383372009156	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372009157	NAD(P) binding site [chemical binding]; other site
383372009158	active site
383372009159	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
383372009160	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
383372009161	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
383372009162	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
383372009163	NAD binding site [chemical binding]; other site
383372009164	substrate binding site [chemical binding]; other site
383372009165	homodimer interface [polypeptide binding]; other site
383372009166	active site
383372009167	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
383372009168	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
383372009169	tandem repeat interface [polypeptide binding]; other site
383372009170	oligomer interface [polypeptide binding]; other site
383372009171	active site residues [active]
383372009172	adhesin; Provisional; Region: PRK09752
383372009173	adhesin; Provisional; Region: PRK09752
383372009174	TM1410 hypothetical-related protein; Region: DUF297; cl00997
383372009175	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372009176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372009177	S-adenosylmethionine binding site [chemical binding]; other site
383372009178	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
383372009179	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372009180	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372009181	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
383372009182	Interdomain contacts; other site
383372009183	Cytokine receptor motif; other site
383372009184	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
383372009185	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372009186	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372009187	S-adenosylmethionine binding site [chemical binding]; other site
383372009188	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
383372009189	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
383372009190	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372009191	Methyltransferase domain; Region: Methyltransf_12; pfam08242
383372009192	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
383372009193	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
383372009194	extended (e) SDRs; Region: SDR_e; cd08946
383372009195	NAD(P) binding site [chemical binding]; other site
383372009196	active site
383372009197	substrate binding site [chemical binding]; other site
383372009198	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
383372009199	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
383372009200	substrate binding site; other site
383372009201	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
383372009202	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
383372009203	active site
383372009204	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
383372009205	dimer interface [polypeptide binding]; other site
383372009206	active site
383372009207	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372009208	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372009209	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372009210	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372009211	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
383372009212	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
383372009213	active site
383372009214	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372009215	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
383372009216	active site
383372009217	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
383372009218	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
383372009219	active site
383372009220	O-Antigen ligase; Region: Wzy_C; pfam04932
383372009221	Chain length determinant protein; Region: Wzz; pfam02706
383372009222	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
383372009223	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
383372009224	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372009225	DXD motif; other site
383372009226	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372009227	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372009228	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
383372009229	putative ADP-binding pocket [chemical binding]; other site
383372009230	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372009231	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
383372009232	Bacterial sugar transferase; Region: Bac_transf; pfam02397
383372009233	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
383372009234	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
383372009235	metal binding site [ion binding]; metal-binding site
383372009236	I-site; other site
383372009237	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372009238	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
383372009239	active site
383372009240	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
383372009241	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
383372009242	dimer interface [polypeptide binding]; other site
383372009243	active site
383372009244	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
383372009245	dimer interface [polypeptide binding]; other site
383372009246	active site
383372009247	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
383372009248	GAF domain; Region: GAF_3; pfam13492
383372009249	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372009250	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372009251	dimer interface [polypeptide binding]; other site
383372009252	phosphorylation site [posttranslational modification]
383372009253	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372009254	ATP binding site [chemical binding]; other site
383372009255	Mg2+ binding site [ion binding]; other site
383372009256	G-X-G motif; other site
383372009257	Right handed beta helix region; Region: Beta_helix; pfam13229
383372009258	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
383372009259	Beta-lactamase; Region: Beta-lactamase; pfam00144
383372009260	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
383372009261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009262	active site
383372009263	phosphorylation site [posttranslational modification]
383372009264	intermolecular recognition site; other site
383372009265	dimerization interface [polypeptide binding]; other site
383372009266	ANTAR domain; Region: ANTAR; pfam03861
383372009267	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
383372009268	homotrimer interaction site [polypeptide binding]; other site
383372009269	active site
383372009270	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
383372009271	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
383372009272	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
383372009273	Family description; Region: VCBS; pfam13517
383372009274	Family description; Region: VCBS; pfam13517
383372009275	Family description; Region: VCBS; pfam13517
383372009276	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
383372009277	Esterase/lipase [General function prediction only]; Region: COG1647
383372009278	transcriptional regulator MalT; Provisional; Region: PRK04841
383372009279	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372009280	TPR motif; other site
383372009281	binding surface
383372009282	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372009283	Bacterial transcriptional activator domain; Region: BTAD; smart01043
383372009284	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
383372009285	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
383372009286	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372009287	Walker A/P-loop; other site
383372009288	ATP binding site [chemical binding]; other site
383372009289	Q-loop/lid; other site
383372009290	ABC transporter signature motif; other site
383372009291	Walker B; other site
383372009292	D-loop; other site
383372009293	H-loop/switch region; other site
383372009294	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
383372009295	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
383372009296	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372009297	Walker A/P-loop; other site
383372009298	ATP binding site [chemical binding]; other site
383372009299	Q-loop/lid; other site
383372009300	ABC transporter signature motif; other site
383372009301	Walker B; other site
383372009302	D-loop; other site
383372009303	H-loop/switch region; other site
383372009304	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372009305	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372009306	dimer interface [polypeptide binding]; other site
383372009307	phosphorylation site [posttranslational modification]
383372009308	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372009309	ATP binding site [chemical binding]; other site
383372009310	Mg2+ binding site [ion binding]; other site
383372009311	G-X-G motif; other site
383372009312	PspC domain; Region: PspC; pfam04024
383372009313	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
383372009314	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
383372009315	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
383372009316	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
383372009317	putative NAD(P) binding site [chemical binding]; other site
383372009318	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
383372009319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009320	active site
383372009321	phosphorylation site [posttranslational modification]
383372009322	intermolecular recognition site; other site
383372009323	dimerization interface [polypeptide binding]; other site
383372009324	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
383372009325	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
383372009326	dimerization interface [polypeptide binding]; other site
383372009327	ligand binding site [chemical binding]; other site
383372009328	PAS domain S-box; Region: sensory_box; TIGR00229
383372009329	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372009330	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372009331	dimer interface [polypeptide binding]; other site
383372009332	phosphorylation site [posttranslational modification]
383372009333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372009334	ATP binding site [chemical binding]; other site
383372009335	Mg2+ binding site [ion binding]; other site
383372009336	G-X-G motif; other site
383372009337	Response regulator receiver domain; Region: Response_reg; pfam00072
383372009338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009339	active site
383372009340	phosphorylation site [posttranslational modification]
383372009341	intermolecular recognition site; other site
383372009342	dimerization interface [polypeptide binding]; other site
383372009343	Response regulator receiver domain; Region: Response_reg; pfam00072
383372009344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009345	active site
383372009346	phosphorylation site [posttranslational modification]
383372009347	intermolecular recognition site; other site
383372009348	dimerization interface [polypeptide binding]; other site
383372009349	PAS fold; Region: PAS_4; pfam08448
383372009350	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372009351	PAS fold; Region: PAS_3; pfam08447
383372009352	putative active site [active]
383372009353	heme pocket [chemical binding]; other site
383372009354	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
383372009355	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
383372009356	metal binding site [ion binding]; metal-binding site
383372009357	active site
383372009358	I-site; other site
383372009359	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
383372009360	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
383372009361	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
383372009362	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372009363	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
383372009364	active site
383372009365	Uncharacterized conserved protein [Function unknown]; Region: COG0398
383372009366	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
383372009367	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372009368	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
383372009369	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
383372009370	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
383372009371	active site
383372009372	PHP-associated; Region: PHP_C; pfam13263
383372009373	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
383372009374	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
383372009375	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
383372009376	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
383372009377	catalytic site [active]
383372009378	TAP-like protein; Region: Abhydrolase_4; pfam08386
383372009379	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
383372009380	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
383372009381	HflX GTPase family; Region: HflX; cd01878
383372009382	G1 box; other site
383372009383	GTP/Mg2+ binding site [chemical binding]; other site
383372009384	Switch I region; other site
383372009385	G2 box; other site
383372009386	G3 box; other site
383372009387	Switch II region; other site
383372009388	G4 box; other site
383372009389	G5 box; other site
383372009390	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
383372009391	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
383372009392	putative substrate-binding site; other site
383372009393	nickel binding site [ion binding]; other site
383372009394	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
383372009395	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
383372009396	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
383372009397	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
383372009398	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
383372009399	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
383372009400	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
383372009401	Walker A/P-loop; other site
383372009402	ATP binding site [chemical binding]; other site
383372009403	Q-loop/lid; other site
383372009404	ABC transporter signature motif; other site
383372009405	Walker B; other site
383372009406	D-loop; other site
383372009407	H-loop/switch region; other site
383372009408	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
383372009409	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
383372009410	Walker A/P-loop; other site
383372009411	ATP binding site [chemical binding]; other site
383372009412	Q-loop/lid; other site
383372009413	ABC transporter signature motif; other site
383372009414	Walker B; other site
383372009415	D-loop; other site
383372009416	H-loop/switch region; other site
383372009417	FtsX-like permease family; Region: FtsX; pfam02687
383372009418	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
383372009419	HlyD family secretion protein; Region: HlyD_3; pfam13437
383372009420	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
383372009421	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
383372009422	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
383372009423	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
383372009424	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
383372009425	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
383372009426	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
383372009427	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
383372009428	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
383372009429	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
383372009430	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
383372009431	protein binding site [polypeptide binding]; other site
383372009432	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
383372009433	Domain interface; other site
383372009434	Peptide binding site; other site
383372009435	Active site tetrad [active]
383372009436	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
383372009437	active site
383372009438	catalytic residues [active]
383372009439	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
383372009440	active site
383372009441	putative substrate binding region [chemical binding]; other site
383372009442	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639
383372009443	FOG: CBS domain [General function prediction only]; Region: COG0517
383372009444	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
383372009445	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
383372009446	ligand binding site [chemical binding]; other site
383372009447	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372009448	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372009449	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009450	active site
383372009451	phosphorylation site [posttranslational modification]
383372009452	intermolecular recognition site; other site
383372009453	dimerization interface [polypeptide binding]; other site
383372009454	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372009455	DNA binding site [nucleotide binding]
383372009456	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372009457	PAS domain; Region: PAS_9; pfam13426
383372009458	putative active site [active]
383372009459	heme pocket [chemical binding]; other site
383372009460	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
383372009461	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372009462	putative active site [active]
383372009463	heme pocket [chemical binding]; other site
383372009464	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372009465	dimer interface [polypeptide binding]; other site
383372009466	phosphorylation site [posttranslational modification]
383372009467	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372009468	ATP binding site [chemical binding]; other site
383372009469	Mg2+ binding site [ion binding]; other site
383372009470	G-X-G motif; other site
383372009471	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
383372009472	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
383372009473	NAD binding site [chemical binding]; other site
383372009474	homodimer interface [polypeptide binding]; other site
383372009475	homotetramer interface [polypeptide binding]; other site
383372009476	active site
383372009477	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
383372009478	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
383372009479	substrate binding site [chemical binding]; other site
383372009480	oxyanion hole (OAH) forming residues; other site
383372009481	trimer interface [polypeptide binding]; other site
383372009482	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
383372009483	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
383372009484	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
383372009485	active site
383372009486	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
383372009487	Ligand binding site [chemical binding]; other site
383372009488	Electron transfer flavoprotein domain; Region: ETF; pfam01012
383372009489	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
383372009490	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
383372009491	Ligand binding site [chemical binding]; other site
383372009492	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
383372009493	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
383372009494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372009495	ATP binding site [chemical binding]; other site
383372009496	Mg2+ binding site [ion binding]; other site
383372009497	G-X-G motif; other site
383372009498	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
383372009499	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372009500	GAF domain; Region: GAF_3; pfam13492
383372009501	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372009502	GAF domain; Region: GAF; pfam01590
383372009503	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372009504	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372009505	dimer interface [polypeptide binding]; other site
383372009506	phosphorylation site [posttranslational modification]
383372009507	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372009508	ATP binding site [chemical binding]; other site
383372009509	Mg2+ binding site [ion binding]; other site
383372009510	G-X-G motif; other site
383372009511	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
383372009512	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
383372009513	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
383372009514	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372009515	dimer interface [polypeptide binding]; other site
383372009516	conserved gate region; other site
383372009517	ABC-ATPase subunit interface; other site
383372009518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372009519	dimer interface [polypeptide binding]; other site
383372009520	conserved gate region; other site
383372009521	putative PBP binding loops; other site
383372009522	ABC-ATPase subunit interface; other site
383372009523	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
383372009524	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
383372009525	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
383372009526	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
383372009527	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
383372009528	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
383372009529	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
383372009530	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
383372009531	active site
383372009532	substrate binding site [chemical binding]; other site
383372009533	cosubstrate binding site; other site
383372009534	catalytic site [active]
383372009535	Response regulator receiver domain; Region: Response_reg; pfam00072
383372009536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009537	active site
383372009538	phosphorylation site [posttranslational modification]
383372009539	intermolecular recognition site; other site
383372009540	dimerization interface [polypeptide binding]; other site
383372009541	GAF domain; Region: GAF; pfam01590
383372009542	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372009543	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372009544	GAF domain; Region: GAF_3; pfam13492
383372009545	GAF domain; Region: GAF; cl17456
383372009546	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372009547	PAS domain; Region: PAS_9; pfam13426
383372009548	putative active site [active]
383372009549	heme pocket [chemical binding]; other site
383372009550	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
383372009551	cyclase homology domain; Region: CHD; cd07302
383372009552	nucleotidyl binding site; other site
383372009553	metal binding site [ion binding]; metal-binding site
383372009554	dimer interface [polypeptide binding]; other site
383372009555	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
383372009556	active site
383372009557	dimer interfaces [polypeptide binding]; other site
383372009558	catalytic residues [active]
383372009559	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
383372009560	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
383372009561	metal binding site [ion binding]; metal-binding site
383372009562	dimer interface [polypeptide binding]; other site
383372009563	cyanophycin synthetase; Provisional; Region: PRK14016
383372009564	HerA helicase [Replication, recombination, and repair]; Region: COG0433
383372009565	HAS barrel domain; Region: HAS-barrel; pfam09378
383372009566	Domain of unknown function DUF87; Region: DUF87; pfam01935
383372009567	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
383372009568	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
383372009569	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
383372009570	protein binding site [polypeptide binding]; other site
383372009571	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
383372009572	threonine synthase; Reviewed; Region: PRK06721
383372009573	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
383372009574	homodimer interface [polypeptide binding]; other site
383372009575	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372009576	catalytic residue [active]
383372009577	aspartate kinase; Provisional; Region: PRK06291
383372009578	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
383372009579	nucleotide binding site [chemical binding]; other site
383372009580	substrate binding site [chemical binding]; other site
383372009581	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
383372009582	dimer interface [polypeptide binding]; other site
383372009583	putative threonine allosteric regulatory site; other site
383372009584	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
383372009585	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
383372009586	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
383372009587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372009588	S-adenosylmethionine binding site [chemical binding]; other site
383372009589	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
383372009590	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
383372009591	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
383372009592	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
383372009593	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
383372009594	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
383372009595	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
383372009596	active site
383372009597	catalytic tetrad [active]
383372009598	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
383372009599	catalytic residues [active]
383372009600	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
383372009601	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372009602	Tetratricopeptide repeat; Region: TPR_16; pfam13432
383372009603	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372009604	TPR motif; other site
383372009605	binding surface
383372009606	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
383372009607	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009608	active site
383372009609	phosphorylation site [posttranslational modification]
383372009610	intermolecular recognition site; other site
383372009611	dimerization interface [polypeptide binding]; other site
383372009612	CheB methylesterase; Region: CheB_methylest; pfam01339
383372009613	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
383372009614	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
383372009615	Response regulator receiver domain; Region: Response_reg; pfam00072
383372009616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009617	active site
383372009618	phosphorylation site [posttranslational modification]
383372009619	intermolecular recognition site; other site
383372009620	dimerization interface [polypeptide binding]; other site
383372009621	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
383372009622	putative binding surface; other site
383372009623	active site
383372009624	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372009625	ATP binding site [chemical binding]; other site
383372009626	Mg2+ binding site [ion binding]; other site
383372009627	G-X-G motif; other site
383372009628	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
383372009629	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
383372009630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009631	active site
383372009632	phosphorylation site [posttranslational modification]
383372009633	intermolecular recognition site; other site
383372009634	dimerization interface [polypeptide binding]; other site
383372009635	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
383372009636	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372009637	dimerization interface [polypeptide binding]; other site
383372009638	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372009639	dimerization interface [polypeptide binding]; other site
383372009640	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
383372009641	dimer interface [polypeptide binding]; other site
383372009642	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
383372009643	putative CheW interface [polypeptide binding]; other site
383372009644	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
383372009645	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
383372009646	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
383372009647	CoA-ligase; Region: Ligase_CoA; pfam00549
383372009648	PspC domain; Region: PspC; pfam04024
383372009649	putative acyltransferase; Provisional; Region: PRK05790
383372009650	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
383372009651	dimer interface [polypeptide binding]; other site
383372009652	active site
383372009653	AAA ATPase domain; Region: AAA_16; pfam13191
383372009654	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
383372009655	FOG: WD40 repeat [General function prediction only]; Region: COG2319
383372009656	structural tetrad; other site
383372009657	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
383372009658	CHAT domain; Region: CHAT; pfam12770
383372009659	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
383372009660	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
383372009661	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372009662	motif II; other site
383372009663	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
383372009664	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
383372009665	Ligand binding site; other site
383372009666	Putative Catalytic site; other site
383372009667	DXD motif; other site
383372009668	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
383372009669	YtkA-like; Region: YtkA; pfam13115
383372009670	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372009671	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372009672	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372009673	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
383372009674	active site
383372009675	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
383372009676	catalytic tetrad [active]
383372009677	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
383372009678	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
383372009679	NADP-binding site; other site
383372009680	homotetramer interface [polypeptide binding]; other site
383372009681	substrate binding site [chemical binding]; other site
383372009682	homodimer interface [polypeptide binding]; other site
383372009683	active site
383372009684	4-aminobutyrate aminotransferase; Provisional; Region: PRK08117
383372009685	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
383372009686	inhibitor-cofactor binding pocket; inhibition site
383372009687	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372009688	catalytic residue [active]
383372009689	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
383372009690	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
383372009691	binding surface
383372009692	TPR motif; other site
383372009693	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372009694	binding surface
383372009695	TPR motif; other site
383372009696	TPR repeat; Region: TPR_11; pfam13414
383372009697	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372009698	binding surface
383372009699	TPR motif; other site
383372009700	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372009701	binding surface
383372009702	TPR motif; other site
383372009703	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372009704	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372009705	TPR motif; other site
383372009706	binding surface
383372009707	TPR repeat; Region: TPR_11; pfam13414
383372009708	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372009709	binding surface
383372009710	TPR motif; other site
383372009711	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372009712	TPR motif; other site
383372009713	Response regulator receiver domain; Region: Response_reg; pfam00072
383372009714	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009715	active site
383372009716	phosphorylation site [posttranslational modification]
383372009717	intermolecular recognition site; other site
383372009718	dimerization interface [polypeptide binding]; other site
383372009719	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
383372009720	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
383372009721	metal binding site [ion binding]; metal-binding site
383372009722	active site
383372009723	I-site; other site
383372009724	Response regulator receiver domain; Region: Response_reg; pfam00072
383372009725	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
383372009726	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
383372009727	substrate binding site [chemical binding]; other site
383372009728	ATP binding site [chemical binding]; other site
383372009729	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
383372009730	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cd02106
383372009731	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242
383372009732	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
383372009733	putative NAD(P) binding site [chemical binding]; other site
383372009734	catalytic Zn binding site [ion binding]; other site
383372009735	structural Zn binding site [ion binding]; other site
383372009736	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
383372009737	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
383372009738	putative active site [active]
383372009739	substrate binding site [chemical binding]; other site
383372009740	putative cosubstrate binding site; other site
383372009741	catalytic site [active]
383372009742	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
383372009743	substrate binding site [chemical binding]; other site
383372009744	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372009745	active site
383372009746	NTP binding site [chemical binding]; other site
383372009747	metal binding triad [ion binding]; metal-binding site
383372009748	antibiotic binding site [chemical binding]; other site
383372009749	HEPN domain; Region: HEPN; pfam05168
383372009750	Haemolytic domain; Region: Haemolytic; pfam01809
383372009751	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
383372009752	MPT binding site; other site
383372009753	trimer interface [polypeptide binding]; other site
383372009754	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
383372009755	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
383372009756	G1 box; other site
383372009757	GTP/Mg2+ binding site [chemical binding]; other site
383372009758	G2 box; other site
383372009759	Switch I region; other site
383372009760	G3 box; other site
383372009761	Switch II region; other site
383372009762	G4 box; other site
383372009763	G5 box; other site
383372009764	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
383372009765	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
383372009766	heme-binding site [chemical binding]; other site
383372009767	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
383372009768	CAAX protease self-immunity; Region: Abi; pfam02517
383372009769	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14338
383372009770	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
383372009771	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372009772	FeS/SAM binding site; other site
383372009773	TRAM domain; Region: TRAM; pfam01938
383372009774	CAAX protease self-immunity; Region: Abi; pfam02517
383372009775	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372009776	binding surface
383372009777	TPR motif; other site
383372009778	TPR repeat; Region: TPR_11; pfam13414
383372009779	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
383372009780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372009781	Walker A motif; other site
383372009782	ATP binding site [chemical binding]; other site
383372009783	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
383372009784	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
383372009785	ATP binding site [chemical binding]; other site
383372009786	Walker A motif; other site
383372009787	hexamer interface [polypeptide binding]; other site
383372009788	Walker B motif; other site
383372009789	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
383372009790	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
383372009791	active site
383372009792	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
383372009793	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
383372009794	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
383372009795	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
383372009796	DDE superfamily endonuclease; Region: DDE_5; cl17874
383372009797	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
383372009798	ATP cone domain; Region: ATP-cone; pfam03477
383372009799	Restriction endonuclease; Region: Mrr_cat; pfam04471
383372009800	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
383372009801	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
383372009802	NAD(P) binding site [chemical binding]; other site
383372009803	homotetramer interface [polypeptide binding]; other site
383372009804	homodimer interface [polypeptide binding]; other site
383372009805	active site
383372009806	transcription antitermination factor NusB; Region: nusB; TIGR01951
383372009807	putative RNA binding site [nucleotide binding]; other site
383372009808	acyl carrier protein; Provisional; Region: acpP; PRK00982
383372009809	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
383372009810	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
383372009811	Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091
383372009812	Peptidase family M48; Region: Peptidase_M48; cl12018
383372009813	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
383372009814	Histidine kinase; Region: HisKA_3; pfam07730
383372009815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372009816	ATP binding site [chemical binding]; other site
383372009817	Mg2+ binding site [ion binding]; other site
383372009818	G-X-G motif; other site
383372009819	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372009820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009821	active site
383372009822	phosphorylation site [posttranslational modification]
383372009823	intermolecular recognition site; other site
383372009824	dimerization interface [polypeptide binding]; other site
383372009825	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372009826	DNA binding residues [nucleotide binding]
383372009827	dimerization interface [polypeptide binding]; other site
383372009828	Domain of unknown function (DUF897); Region: DUF897; pfam05982
383372009829	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372009830	S-adenosylmethionine binding site [chemical binding]; other site
383372009831	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
383372009832	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
383372009833	Queuine tRNA-ribosyltransferase; Region: TGT; pfam01702
383372009834	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
383372009835	active site
383372009836	dimer interface [polypeptide binding]; other site
383372009837	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
383372009838	competence damage-inducible protein A; Provisional; Region: PRK01215
383372009839	putative MPT binding site; other site
383372009840	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
383372009841	MOFRL family; Region: MOFRL; pfam05161
383372009842	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
383372009843	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
383372009844	active site
383372009845	Zn binding site [ion binding]; other site
383372009846	TPR repeat; Region: TPR_11; pfam13414
383372009847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372009848	TPR motif; other site
383372009849	binding surface
383372009850	TPR repeat; Region: TPR_11; pfam13414
383372009851	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372009852	binding surface
383372009853	TPR motif; other site
383372009854	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
383372009855	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
383372009856	metal ion-dependent adhesion site (MIDAS); other site
383372009857	Protein kinase domain; Region: Pkinase; pfam00069
383372009858	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372009859	active site
383372009860	ATP binding site [chemical binding]; other site
383372009861	substrate binding site [chemical binding]; other site
383372009862	activation loop (A-loop); other site
383372009863	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372009864	Double zinc ribbon; Region: DZR; pfam12773
383372009865	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372009866	phosphopeptide binding site; other site
383372009867	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372009868	CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507
383372009869	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
383372009870	conserved cys residue [active]
383372009871	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
383372009872	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
383372009873	substrate binding pocket [chemical binding]; other site
383372009874	membrane-bound complex binding site; other site
383372009875	hinge residues; other site
383372009876	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
383372009877	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372009878	Walker A motif; other site
383372009879	ATP binding site [chemical binding]; other site
383372009880	Walker B motif; other site
383372009881	Peptidase family M41; Region: Peptidase_M41; pfam01434
383372009882	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
383372009883	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
383372009884	NADP-binding site; other site
383372009885	homotetramer interface [polypeptide binding]; other site
383372009886	substrate binding site [chemical binding]; other site
383372009887	homodimer interface [polypeptide binding]; other site
383372009888	active site
383372009889	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
383372009890	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
383372009891	active site
383372009892	Substrate binding site; other site
383372009893	Mg++ binding site; other site
383372009894	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
383372009895	putative trimer interface [polypeptide binding]; other site
383372009896	putative CoA binding site [chemical binding]; other site
383372009897	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
383372009898	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
383372009899	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
383372009900	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
383372009901	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
383372009902	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
383372009903	Ferritin-like domain; Region: Ferritin; pfam00210
383372009904	ferroxidase diiron center [ion binding]; other site
383372009905	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
383372009906	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732
383372009907	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439
383372009908	CRISPR-associated protein; Region: TIGR03986
383372009909	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
383372009910	CRISPR-associated protein; Region: TIGR03986
383372009911	RAMP superfamily; Region: RAMPs; pfam03787
383372009912	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
383372009913	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
383372009914	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
383372009915	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558
383372009916	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
383372009917	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
383372009918	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839
383372009919	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372009920	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372009921	DNA binding residues [nucleotide binding]
383372009922	AAA domain; Region: AAA_33; pfam13671
383372009923	CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cl09837
383372009924	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
383372009925	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
383372009926	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
383372009927	CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895
383372009928	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693
383372009929	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
383372009930	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
383372009931	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
383372009932	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
383372009933	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
383372009934	CRISPR associated protein Cas2; Region: CRISPR_Cas2; pfam09827
383372009935	CRISPR-associated protein Cas4; Region: cas4; TIGR00372
383372009936	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
383372009937	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372009938	FeS/SAM binding site; other site
383372009939	HemN C-terminal domain; Region: HemN_C; pfam06969
383372009940	CHASE4 domain; Region: CHASE4; pfam05228
383372009941	HAMP domain; Region: HAMP; pfam00672
383372009942	dimerization interface [polypeptide binding]; other site
383372009943	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372009944	PAS domain; Region: PAS_8; pfam13188
383372009945	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372009946	dimer interface [polypeptide binding]; other site
383372009947	phosphorylation site [posttranslational modification]
383372009948	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372009949	ATP binding site [chemical binding]; other site
383372009950	Mg2+ binding site [ion binding]; other site
383372009951	G-X-G motif; other site
383372009952	Response regulator receiver domain; Region: Response_reg; pfam00072
383372009953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009954	active site
383372009955	phosphorylation site [posttranslational modification]
383372009956	intermolecular recognition site; other site
383372009957	dimerization interface [polypeptide binding]; other site
383372009958	Response regulator receiver domain; Region: Response_reg; pfam00072
383372009959	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009960	active site
383372009961	phosphorylation site [posttranslational modification]
383372009962	intermolecular recognition site; other site
383372009963	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
383372009964	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009965	active site
383372009966	phosphorylation site [posttranslational modification]
383372009967	intermolecular recognition site; other site
383372009968	dimerization interface [polypeptide binding]; other site
383372009969	Response regulator receiver domain; Region: Response_reg; pfam00072
383372009970	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372009971	active site
383372009972	phosphorylation site [posttranslational modification]
383372009973	intermolecular recognition site; other site
383372009974	dimerization interface [polypeptide binding]; other site
383372009975	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372009976	PAS domain; Region: PAS_9; pfam13426
383372009977	putative active site [active]
383372009978	heme pocket [chemical binding]; other site
383372009979	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372009980	PAS fold; Region: PAS_3; pfam08447
383372009981	putative active site [active]
383372009982	heme pocket [chemical binding]; other site
383372009983	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
383372009984	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
383372009985	metal binding site [ion binding]; metal-binding site
383372009986	active site
383372009987	I-site; other site
383372009988	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
383372009989	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
383372009990	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
383372009991	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
383372009992	active site
383372009993	dimer interface [polypeptide binding]; other site
383372009994	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
383372009995	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
383372009996	active site
383372009997	Substrate binding site; other site
383372009998	Mg++ binding site; other site
383372009999	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
383372010000	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
383372010001	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
383372010002	dimer interaction site [polypeptide binding]; other site
383372010003	substrate-binding tunnel; other site
383372010004	active site
383372010005	catalytic site [active]
383372010006	substrate binding site [chemical binding]; other site
383372010007	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
383372010008	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372010009	putative substrate translocation pore; other site
383372010010	Major Facilitator Superfamily; Region: MFS_1; pfam07690
383372010011	Protein of unknown function DUF45; Region: DUF45; cl00636
383372010012	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
383372010013	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
383372010014	active site
383372010015	catalytic residues [active]
383372010016	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
383372010017	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
383372010018	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
383372010019	FeoA domain; Region: FeoA; pfam04023
383372010020	UGMP family protein; Validated; Region: PRK09604
383372010021	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
383372010022	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372010023	S-adenosylmethionine binding site [chemical binding]; other site
383372010024	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
383372010025	Protein export membrane protein; Region: SecD_SecF; cl14618
383372010026	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
383372010027	protein-export membrane protein SecD; Region: secD; TIGR01129
383372010028	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
383372010029	Thioredoxin; Region: Thioredoxin_4; pfam13462
383372010030	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
383372010031	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
383372010032	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
383372010033	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
383372010034	ATP binding site [chemical binding]; other site
383372010035	putative Mg++ binding site [ion binding]; other site
383372010036	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
383372010037	nucleotide binding region [chemical binding]; other site
383372010038	ATP-binding site [chemical binding]; other site
383372010039	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596
383372010040	active site
383372010041	Zn binding site [ion binding]; other site
383372010042	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
383372010043	catalytic core [active]
383372010044	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
383372010045	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
383372010046	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
383372010047	minor groove reading motif; other site
383372010048	helix-hairpin-helix signature motif; other site
383372010049	active site
383372010050	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
383372010051	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
383372010052	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
383372010053	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
383372010054	acyl-activating enzyme (AAE) consensus motif; other site
383372010055	putative AMP binding site [chemical binding]; other site
383372010056	putative active site [active]
383372010057	putative CoA binding site [chemical binding]; other site
383372010058	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
383372010059	catalytic residues [active]
383372010060	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
383372010061	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
383372010062	catalytic residues [active]
383372010063	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
383372010064	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372010065	Double zinc ribbon; Region: DZR; pfam12773
383372010066	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
383372010067	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372010068	S-adenosylmethionine binding site [chemical binding]; other site
383372010069	Double zinc ribbon; Region: DZR; pfam12773
383372010070	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
383372010071	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372010072	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372010073	active site
383372010074	ATP binding site [chemical binding]; other site
383372010075	substrate binding site [chemical binding]; other site
383372010076	activation loop (A-loop); other site
383372010077	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372010078	Double zinc ribbon; Region: DZR; pfam12773
383372010079	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
383372010080	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
383372010081	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
383372010082	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
383372010083	CARDB; Region: CARDB; pfam07705
383372010084	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
383372010085	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
383372010086	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
383372010087	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
383372010088	heterotetramer interface [polypeptide binding]; other site
383372010089	active site pocket [active]
383372010090	cleavage site
383372010091	argininosuccinate synthase; Provisional; Region: PRK13820
383372010092	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
383372010093	ANP binding site [chemical binding]; other site
383372010094	Substrate Binding Site II [chemical binding]; other site
383372010095	Substrate Binding Site I [chemical binding]; other site
383372010096	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
383372010097	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
383372010098	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
383372010099	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
383372010100	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
383372010101	ATP-grasp domain; Region: ATP-grasp_4; cl17255
383372010102	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
383372010103	IMP binding site; other site
383372010104	dimer interface [polypeptide binding]; other site
383372010105	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
383372010106	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
383372010107	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
383372010108	catalytic site [active]
383372010109	subunit interface [polypeptide binding]; other site
383372010110	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
383372010111	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372010112	Coenzyme A binding pocket [chemical binding]; other site
383372010113	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
383372010114	nucleotide binding site [chemical binding]; other site
383372010115	N-acetyl-L-glutamate binding site [chemical binding]; other site
383372010116	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
383372010117	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
383372010118	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
383372010119	homodimer interface [polypeptide binding]; other site
383372010120	substrate-cofactor binding pocket; other site
383372010121	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372010122	catalytic residue [active]
383372010123	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
383372010124	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
383372010125	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
383372010126	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
383372010127	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
383372010128	active site
383372010129	(T/H)XGH motif; other site
383372010130	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
383372010131	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
383372010132	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
383372010133	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
383372010134	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372010135	putative active site [active]
383372010136	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372010137	putative active site [active]
383372010138	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372010139	putative active site [active]
383372010140	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372010141	putative active site [active]
383372010142	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
383372010143	Part of AAA domain; Region: AAA_19; pfam13245
383372010144	Family description; Region: UvrD_C_2; pfam13538
383372010145	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
383372010146	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
383372010147	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
383372010148	catalytic site [active]
383372010149	TAP-like protein; Region: Abhydrolase_4; pfam08386
383372010150	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372010151	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372010152	active site
383372010153	ATP binding site [chemical binding]; other site
383372010154	substrate binding site [chemical binding]; other site
383372010155	activation loop (A-loop); other site
383372010156	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
383372010157	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
383372010158	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
383372010159	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
383372010160	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
383372010161	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
383372010162	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
383372010163	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
383372010164	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
383372010165	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
383372010166	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
383372010167	4Fe-4S binding domain; Region: Fer4; pfam00037
383372010168	4Fe-4S binding domain; Region: Fer4; pfam00037
383372010169	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
383372010170	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
383372010171	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
383372010172	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
383372010173	catalytic loop [active]
383372010174	iron binding site [ion binding]; other site
383372010175	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
383372010176	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
383372010177	molybdopterin cofactor binding site; other site
383372010178	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
383372010179	molybdopterin cofactor binding site; other site
383372010180	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372010181	putative active site [active]
383372010182	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
383372010183	SLBB domain; Region: SLBB; pfam10531
383372010184	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
383372010185	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372010186	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372010187	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
383372010188	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
383372010189	hydroxyglutarate oxidase; Provisional; Region: PRK11728
383372010190	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
383372010191	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372010192	putative active site [active]
383372010193	adenylate kinase; Reviewed; Region: adk; PRK00279
383372010194	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
383372010195	AMP-binding site [chemical binding]; other site
383372010196	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
383372010197	haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562
383372010198	Translin family; Region: Translin; cl00957
383372010199	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
383372010200	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
383372010201	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
383372010202	Walker A/P-loop; other site
383372010203	ATP binding site [chemical binding]; other site
383372010204	Q-loop/lid; other site
383372010205	ABC transporter signature motif; other site
383372010206	Walker B; other site
383372010207	D-loop; other site
383372010208	H-loop/switch region; other site
383372010209	deoxyhypusine synthase; Region: dhys; TIGR00321
383372010210	Deoxyhypusine synthase; Region: DS; cl00826
383372010211	hypothetical protein; Provisional; Region: PRK06921
383372010212	Clp protease; Region: CLP_protease; pfam00574
383372010213	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
383372010214	oligomer interface [polypeptide binding]; other site
383372010215	active site residues [active]
383372010216	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
383372010217	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
383372010218	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
383372010219	NAD binding site [chemical binding]; other site
383372010220	homotetramer interface [polypeptide binding]; other site
383372010221	homodimer interface [polypeptide binding]; other site
383372010222	substrate binding site [chemical binding]; other site
383372010223	active site
383372010224	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
383372010225	Domain of unknown function DUF20; Region: UPF0118; pfam01594
383372010226	cell division topological specificity factor MinE; Provisional; Region: PRK13991
383372010227	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
383372010228	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
383372010229	Switch I; other site
383372010230	Switch II; other site
383372010231	septum formation inhibitor; Reviewed; Region: minC; PRK00513
383372010232	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
383372010233	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
383372010234	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
383372010235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372010236	homodimer interface [polypeptide binding]; other site
383372010237	catalytic residue [active]
383372010238	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
383372010239	Flavoprotein; Region: Flavoprotein; pfam02441
383372010240	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
383372010241	HEAT repeats; Region: HEAT_2; pfam13646
383372010242	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
383372010243	YceG-like family; Region: YceG; pfam02618
383372010244	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
383372010245	dimerization interface [polypeptide binding]; other site
383372010246	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
383372010247	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
383372010248	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
383372010249	shikimate binding site; other site
383372010250	NAD(P) binding site [chemical binding]; other site
383372010251	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
383372010252	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
383372010253	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
383372010254	catalytic triad [active]
383372010255	putative active site [active]
383372010256	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
383372010257	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372010258	dimerization interface [polypeptide binding]; other site
383372010259	GAF domain; Region: GAF; pfam01590
383372010260	GAF domain; Region: GAF_2; pfam13185
383372010261	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372010262	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372010263	putative active site [active]
383372010264	heme pocket [chemical binding]; other site
383372010265	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372010266	dimer interface [polypeptide binding]; other site
383372010267	phosphorylation site [posttranslational modification]
383372010268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372010269	ATP binding site [chemical binding]; other site
383372010270	Mg2+ binding site [ion binding]; other site
383372010271	G-X-G motif; other site
383372010272	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372010273	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372010274	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372010275	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372010276	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372010277	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372010278	putative active site [active]
383372010279	heme pocket [chemical binding]; other site
383372010280	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372010281	dimer interface [polypeptide binding]; other site
383372010282	phosphorylation site [posttranslational modification]
383372010283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372010284	ATP binding site [chemical binding]; other site
383372010285	Mg2+ binding site [ion binding]; other site
383372010286	G-X-G motif; other site
383372010287	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
383372010288	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
383372010289	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
383372010290	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
383372010291	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372010292	Double zinc ribbon; Region: DZR; pfam12773
383372010293	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372010294	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372010295	GAF domain; Region: GAF; cl17456
383372010296	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372010297	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372010298	dimer interface [polypeptide binding]; other site
383372010299	phosphorylation site [posttranslational modification]
383372010300	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372010301	ATP binding site [chemical binding]; other site
383372010302	Mg2+ binding site [ion binding]; other site
383372010303	G-X-G motif; other site
383372010304	Predicted permeases [General function prediction only]; Region: RarD; COG2962
383372010305	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
383372010306	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
383372010307	CcmE; Region: CcmE; cl00994
383372010308	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
383372010309	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
383372010310	ligand binding site [chemical binding]; other site
383372010311	flexible hinge region; other site
383372010312	putative switch regulator; other site
383372010313	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
383372010314	non-specific DNA interactions [nucleotide binding]; other site
383372010315	DNA binding site [nucleotide binding]
383372010316	sequence specific DNA binding site [nucleotide binding]; other site
383372010317	putative cAMP binding site [chemical binding]; other site
383372010318	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
383372010319	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
383372010320	FAD binding domain; Region: FAD_binding_4; pfam01565
383372010321	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
383372010322	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
383372010323	FAD binding domain; Region: FAD_binding_4; pfam01565
383372010324	Cytochrome c; Region: Cytochrom_C; cl11414
383372010325	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
383372010326	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
383372010327	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
383372010328	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
383372010329	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
383372010330	NAD binding site [chemical binding]; other site
383372010331	substrate binding site [chemical binding]; other site
383372010332	homodimer interface [polypeptide binding]; other site
383372010333	active site
383372010334	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
383372010335	amidase catalytic site [active]
383372010336	Zn binding residues [ion binding]; other site
383372010337	substrate binding site [chemical binding]; other site
383372010338	PA14 domain; Region: PA14; cl08459
383372010339	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
383372010340	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
383372010341	Competence protein; Region: Competence; pfam03772
383372010342	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372010343	dimerization interface [polypeptide binding]; other site
383372010344	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372010345	dimerization interface [polypeptide binding]; other site
383372010346	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
383372010347	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
383372010348	dimer interface [polypeptide binding]; other site
383372010349	putative CheW interface [polypeptide binding]; other site
383372010350	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372010351	putative active site [active]
383372010352	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
383372010353	Peptidase M30; Region: Peptidase_M30; pfam10460
383372010354	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
383372010355	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
383372010356	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
383372010357	Found in ATP-dependent protease La (LON); Region: LON; smart00464
383372010358	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372010359	Walker A motif; other site
383372010360	ATP binding site [chemical binding]; other site
383372010361	Walker B motif; other site
383372010362	arginine finger; other site
383372010363	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
383372010364	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
383372010365	Phosphotransferase enzyme family; Region: APH; pfam01636
383372010366	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
383372010367	CoA-transferase family III; Region: CoA_transf_3; pfam02515
383372010368	SEC-C motif; Region: SEC-C; pfam02810
383372010369	HicB family; Region: HicB; pfam05534
383372010370	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
383372010371	active site
383372010372	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
383372010373	catalytic core [active]
383372010374	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
383372010375	RDD family; Region: RDD; pfam06271
383372010376	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
383372010377	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
383372010378	putative active site [active]
383372010379	Zn binding site [ion binding]; other site
383372010380	ATP-dependent DNA ligase; Validated; Region: PRK09247
383372010381	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
383372010382	active site
383372010383	DNA binding site [nucleotide binding]
383372010384	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
383372010385	DNA binding site [nucleotide binding]
383372010386	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
383372010387	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
383372010388	N- and C-terminal domain interface [polypeptide binding]; other site
383372010389	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
383372010390	active site
383372010391	putative catalytic site [active]
383372010392	metal binding site [ion binding]; metal-binding site
383372010393	ATP binding site [chemical binding]; other site
383372010394	carbohydrate binding site [chemical binding]; other site
383372010395	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632
383372010396	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
383372010397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372010398	NAD(P) binding site [chemical binding]; other site
383372010399	active site
383372010400	L-rhamnose isomerase; Provisional; Region: PRK01076
383372010401	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
383372010402	Domain of unknown function (DUF718); Region: DUF718; pfam05336
383372010403	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
383372010404	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
383372010405	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
383372010406	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372010407	putative active site [active]
383372010408	acetyl-lysine deacetylase; Provisional; Region: PRK04443
383372010409	M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653
383372010410	metal binding site [ion binding]; metal-binding site
383372010411	putative dimer interface [polypeptide binding]; other site
383372010412	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
383372010413	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
383372010414	inhibitor-cofactor binding pocket; inhibition site
383372010415	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372010416	catalytic residue [active]
383372010417	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
383372010418	drug efflux system protein MdtG; Provisional; Region: PRK09874
383372010419	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372010420	putative substrate translocation pore; other site
383372010421	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
383372010422	AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251
383372010423	putative N-acetyl-L-glutamate binding site [chemical binding]; other site
383372010424	putative nucleotide binding site [chemical binding]; other site
383372010425	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
383372010426	active site
383372010427	metal binding site [ion binding]; metal-binding site
383372010428	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
383372010429	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
383372010430	Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144
383372010431	ATP-grasp domain; Region: ATP-grasp_4; cl17255
383372010432	lysine biosynthesis protein LysW; Region: lysW; TIGR01206
383372010433	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
383372010434	tartrate dehydrogenase; Provisional; Region: PRK08194
383372010435	homoaconitate hydratase small subunit; Provisional; Region: PRK14023
383372010436	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
383372010437	substrate binding site [chemical binding]; other site
383372010438	cystathionine gamma-synthase; Provisional; Region: PRK07811
383372010439	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
383372010440	homodimer interface [polypeptide binding]; other site
383372010441	substrate-cofactor binding pocket; other site
383372010442	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372010443	catalytic residue [active]
383372010444	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
383372010445	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
383372010446	substrate binding site [chemical binding]; other site
383372010447	ligand binding site [chemical binding]; other site
383372010448	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
383372010449	active site
383372010450	catalytic residues [active]
383372010451	metal binding site [ion binding]; metal-binding site
383372010452	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
383372010453	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
383372010454	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
383372010455	P loop; other site
383372010456	GTP binding site [chemical binding]; other site
383372010457	lysine biosynthesis protein LysW; Region: lysW; TIGR01206
383372010458	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
383372010459	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
383372010460	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
383372010461	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
383372010462	Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695
383372010463	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
383372010464	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
383372010465	Uncharacterized conserved protein [Function unknown]; Region: COG0432
383372010466	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372010467	putative active site [active]
383372010468	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
383372010469	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
383372010470	putative catalytic residue [active]
383372010471	phytoene desaturase; Region: crtI_fam; TIGR02734
383372010472	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
383372010473	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
383372010474	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
383372010475	activation loop (A-loop); other site
383372010476	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
383372010477	structural tetrad; other site
383372010478	PQQ-like domain; Region: PQQ_2; pfam13360
383372010479	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
383372010480	structural tetrad; other site
383372010481	FOG: WD40 repeat [General function prediction only]; Region: COG2319
383372010482	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
383372010483	Isochorismatase family; Region: Isochorismatase; pfam00857
383372010484	N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015
383372010485	catalytic triad [active]
383372010486	substrate binding site [chemical binding]; other site
383372010487	domain interfaces; other site
383372010488	conserved cis-peptide bond; other site
383372010489	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
383372010490	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
383372010491	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
383372010492	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
383372010493	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
383372010494	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
383372010495	active site
383372010496	catalytic residues [active]
383372010497	metal binding site [ion binding]; metal-binding site
383372010498	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
383372010499	CoA-transferase family III; Region: CoA_transf_3; pfam02515
383372010500	Transcriptional regulators [Transcription]; Region: GntR; COG1802
383372010501	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
383372010502	DNA-binding site [nucleotide binding]; DNA binding site
383372010503	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
383372010504	SnoaL-like domain; Region: SnoaL_3; pfam13474
383372010505	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
383372010506	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
383372010507	Walker A/P-loop; other site
383372010508	ATP binding site [chemical binding]; other site
383372010509	Q-loop/lid; other site
383372010510	ABC transporter signature motif; other site
383372010511	Walker B; other site
383372010512	D-loop; other site
383372010513	H-loop/switch region; other site
383372010514	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
383372010515	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
383372010516	TM-ABC transporter signature motif; other site
383372010517	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
383372010518	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
383372010519	Walker A/P-loop; other site
383372010520	ATP binding site [chemical binding]; other site
383372010521	Q-loop/lid; other site
383372010522	ABC transporter signature motif; other site
383372010523	Walker B; other site
383372010524	D-loop; other site
383372010525	H-loop/switch region; other site
383372010526	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
383372010527	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
383372010528	TM-ABC transporter signature motif; other site
383372010529	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
383372010530	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
383372010531	ligand binding site [chemical binding]; other site
383372010532	Cupin domain; Region: Cupin_2; cl17218
383372010533	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
383372010534	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
383372010535	NAD(P) binding site [chemical binding]; other site
383372010536	catalytic residues [active]
383372010537	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582
383372010538	Predicted amidohydrolase [General function prediction only]; Region: COG0388
383372010539	putative active site [active]
383372010540	catalytic triad [active]
383372010541	putative dimer interface [polypeptide binding]; other site
383372010542	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
383372010543	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
383372010544	SnoaL-like domain; Region: SnoaL_2; pfam12680
383372010545	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
383372010546	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
383372010547	DNA-binding site [nucleotide binding]; DNA binding site
383372010548	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
383372010549	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
383372010550	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
383372010551	trimer interface [polypeptide binding]; other site
383372010552	putative Zn binding site [ion binding]; other site
383372010553	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
383372010554	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
383372010555	catalytic triad [active]
383372010556	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
383372010557	active site
383372010558	catalytic residues [active]
383372010559	metal binding site [ion binding]; metal-binding site
383372010560	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
383372010561	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
383372010562	substrate binding site [chemical binding]; other site
383372010563	ligand binding site [chemical binding]; other site
383372010564	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
383372010565	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
383372010566	substrate binding site [chemical binding]; other site
383372010567	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
383372010568	CoA-transferase family III; Region: CoA_transf_3; pfam02515
383372010569	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
383372010570	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
383372010571	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
383372010572	active site
383372010573	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
383372010574	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372010575	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
383372010576	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
383372010577	Catalytic site [active]
383372010578	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
383372010579	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372010580	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372010581	phosphopeptide binding site; other site
383372010582	GTP-binding protein Der; Reviewed; Region: PRK00093
383372010583	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
383372010584	G1 box; other site
383372010585	GTP/Mg2+ binding site [chemical binding]; other site
383372010586	Switch I region; other site
383372010587	G2 box; other site
383372010588	Switch II region; other site
383372010589	G3 box; other site
383372010590	G4 box; other site
383372010591	G5 box; other site
383372010592	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
383372010593	G1 box; other site
383372010594	GTP/Mg2+ binding site [chemical binding]; other site
383372010595	Switch I region; other site
383372010596	G2 box; other site
383372010597	G3 box; other site
383372010598	Switch II region; other site
383372010599	G4 box; other site
383372010600	G5 box; other site
383372010601	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372010602	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372010603	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372010604	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372010605	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
383372010606	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
383372010607	Zn2+ binding site [ion binding]; other site
383372010608	Mg2+ binding site [ion binding]; other site
383372010609	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
383372010610	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
383372010611	Protein of unknown function (DUF512); Region: DUF512; pfam04459
383372010612	malate dehydrogenase; Provisional; Region: PRK13529
383372010613	Malic enzyme, N-terminal domain; Region: malic; pfam00390
383372010614	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
383372010615	NAD(P) binding site [chemical binding]; other site
383372010616	excinuclease ABC subunit B; Provisional; Region: PRK05298
383372010617	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
383372010618	nucleotide binding region [chemical binding]; other site
383372010619	ATP-binding site [chemical binding]; other site
383372010620	Ultra-violet resistance protein B; Region: UvrB; pfam12344
383372010621	MutS domain I; Region: MutS_I; pfam01624
383372010622	MutS domain II; Region: MutS_II; pfam05188
383372010623	MutS domain III; Region: MutS_III; pfam05192
383372010624	MutS domain III; Region: MutS_III; pfam05192
383372010625	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
383372010626	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
383372010627	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
383372010628	Walker A/P-loop; other site
383372010629	ATP binding site [chemical binding]; other site
383372010630	Q-loop/lid; other site
383372010631	ABC transporter signature motif; other site
383372010632	Walker B; other site
383372010633	D-loop; other site
383372010634	H-loop/switch region; other site
383372010635	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
383372010636	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
383372010637	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
383372010638	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
383372010639	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
383372010640	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
383372010641	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
383372010642	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
383372010643	protein binding site [polypeptide binding]; other site
383372010644	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
383372010645	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
383372010646	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
383372010647	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
383372010648	polyphosphate kinase; Provisional; Region: PRK05443
383372010649	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
383372010650	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
383372010651	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
383372010652	putative domain interface [polypeptide binding]; other site
383372010653	putative active site [active]
383372010654	catalytic site [active]
383372010655	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
383372010656	putative domain interface [polypeptide binding]; other site
383372010657	putative active site [active]
383372010658	catalytic site [active]
383372010659	Protein of unknown function (DUF1405); Region: DUF1405; pfam07187
383372010660	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
383372010661	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
383372010662	trimer interface [polypeptide binding]; other site
383372010663	active site
383372010664	substrate binding site [chemical binding]; other site
383372010665	CoA binding site [chemical binding]; other site
383372010666	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
383372010667	active site
383372010668	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
383372010669	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
383372010670	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
383372010671	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
383372010672	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
383372010673	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
383372010674	Protein of unknown function DUF262; Region: DUF262; pfam03235
383372010675	Uncharacterized conserved protein [Function unknown]; Region: COG4938
383372010676	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372010677	Walker A/P-loop; other site
383372010678	ATP binding site [chemical binding]; other site
383372010679	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
383372010680	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
383372010681	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
383372010682	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372010683	Walker A/P-loop; other site
383372010684	ATP binding site [chemical binding]; other site
383372010685	Q-loop/lid; other site
383372010686	ABC transporter signature motif; other site
383372010687	Walker B; other site
383372010688	D-loop; other site
383372010689	H-loop/switch region; other site
383372010690	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
383372010691	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
383372010692	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
383372010693	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
383372010694	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
383372010695	Walker A/P-loop; other site
383372010696	ATP binding site [chemical binding]; other site
383372010697	Q-loop/lid; other site
383372010698	ABC transporter signature motif; other site
383372010699	Walker B; other site
383372010700	D-loop; other site
383372010701	H-loop/switch region; other site
383372010702	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
383372010703	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
383372010704	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
383372010705	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
383372010706	Subunit I/III interface [polypeptide binding]; other site
383372010707	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
383372010708	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
383372010709	D-pathway; other site
383372010710	Putative ubiquinol binding site [chemical binding]; other site
383372010711	Low-spin heme (heme b) binding site [chemical binding]; other site
383372010712	Putative water exit pathway; other site
383372010713	Binuclear center (heme o3/CuB) [ion binding]; other site
383372010714	K-pathway; other site
383372010715	Putative proton exit pathway; other site
383372010716	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
383372010717	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
383372010718	Cytochrome c; Region: Cytochrom_C; cl11414
383372010719	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
383372010720	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
383372010721	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
383372010722	Probable zinc-binding domain; Region: zf-trcl; pfam13451
383372010723	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
383372010724	Predicted transcriptional regulators [Transcription]; Region: COG1725
383372010725	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
383372010726	DNA-binding site [nucleotide binding]; DNA binding site
383372010727	Melibiase; Region: Melibiase; pfam02065
383372010728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372010729	dimer interface [polypeptide binding]; other site
383372010730	conserved gate region; other site
383372010731	putative PBP binding loops; other site
383372010732	ABC-ATPase subunit interface; other site
383372010733	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
383372010734	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372010735	dimer interface [polypeptide binding]; other site
383372010736	conserved gate region; other site
383372010737	putative PBP binding loops; other site
383372010738	ABC-ATPase subunit interface; other site
383372010739	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
383372010740	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
383372010741	Melibiase; Region: Melibiase; pfam02065
383372010742	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
383372010743	active site
383372010744	catalytic residues [active]
383372010745	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
383372010746	classical (c) SDRs; Region: SDR_c; cd05233
383372010747	NAD(P) binding site [chemical binding]; other site
383372010748	active site
383372010749	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372010750	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
383372010751	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372010752	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372010753	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372010754	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372010755	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372010756	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372010757	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
383372010758	catalytic residues [active]
383372010759	Rdx family; Region: Rdx; pfam10262
383372010760	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
383372010761	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
383372010762	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
383372010763	TPP-binding site [chemical binding]; other site
383372010764	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
383372010765	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
383372010766	dimer interface [polypeptide binding]; other site
383372010767	PYR/PP interface [polypeptide binding]; other site
383372010768	TPP binding site [chemical binding]; other site
383372010769	substrate binding site [chemical binding]; other site
383372010770	2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626
383372010771	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
383372010772	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372010773	FeS/SAM binding site; other site
383372010774	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
383372010775	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
383372010776	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
383372010777	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14461
383372010778	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
383372010779	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
383372010780	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
383372010781	catalytic residue [active]
383372010782	oligoendopeptidase F; Region: pepF; TIGR00181
383372010783	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
383372010784	active site
383372010785	Zn binding site [ion binding]; other site
383372010786	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
383372010787	putative active site [active]
383372010788	putative metal binding residues [ion binding]; other site
383372010789	signature motif; other site
383372010790	putative triphosphate binding site [ion binding]; other site
383372010791	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
383372010792	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
383372010793	16S/18S rRNA binding site [nucleotide binding]; other site
383372010794	S13e-L30e interaction site [polypeptide binding]; other site
383372010795	25S rRNA binding site [nucleotide binding]; other site
383372010796	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
383372010797	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
383372010798	RNase E interface [polypeptide binding]; other site
383372010799	trimer interface [polypeptide binding]; other site
383372010800	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
383372010801	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
383372010802	RNase E interface [polypeptide binding]; other site
383372010803	trimer interface [polypeptide binding]; other site
383372010804	active site
383372010805	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
383372010806	putative nucleic acid binding region [nucleotide binding]; other site
383372010807	G-X-X-G motif; other site
383372010808	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
383372010809	RNA binding site [nucleotide binding]; other site
383372010810	domain interface; other site
383372010811	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
383372010812	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
383372010813	transmembrane helices; other site
383372010814	CAAX protease self-immunity; Region: Abi; pfam02517
383372010815	mevalonate kinase; Region: mevalon_kin; TIGR00549
383372010816	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
383372010817	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
383372010818	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372010819	S-adenosylmethionine binding site [chemical binding]; other site
383372010820	hypothetical protein; Provisional; Region: PRK05858
383372010821	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
383372010822	PYR/PP interface [polypeptide binding]; other site
383372010823	dimer interface [polypeptide binding]; other site
383372010824	TPP binding site [chemical binding]; other site
383372010825	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
383372010826	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
383372010827	TPP-binding site; other site
383372010828	dimer interface [polypeptide binding]; other site
383372010829	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
383372010830	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
383372010831	Ligand binding site [chemical binding]; other site
383372010832	Electron transfer flavoprotein domain; Region: ETF; pfam01012
383372010833	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
383372010834	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
383372010835	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
383372010836	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
383372010837	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
383372010838	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
383372010839	PAS fold; Region: PAS_4; pfam08448
383372010840	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
383372010841	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372010842	dimer interface [polypeptide binding]; other site
383372010843	phosphorylation site [posttranslational modification]
383372010844	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372010845	ATP binding site [chemical binding]; other site
383372010846	Mg2+ binding site [ion binding]; other site
383372010847	G-X-G motif; other site
383372010848	Response regulator receiver domain; Region: Response_reg; pfam00072
383372010849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372010850	active site
383372010851	phosphorylation site [posttranslational modification]
383372010852	intermolecular recognition site; other site
383372010853	dimerization interface [polypeptide binding]; other site
383372010854	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
383372010855	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
383372010856	Rab subfamily motif 1 (RabSF1); other site
383372010857	G1 box; other site
383372010858	GTP/Mg2+ binding site [chemical binding]; other site
383372010859	Rab subfamily motif 2 (RabSF2); other site
383372010860	Switch I region; other site
383372010861	G2 box; other site
383372010862	effector interaction site; other site
383372010863	GDI interaction site; other site
383372010864	Rab family motif 1 (RabF1); other site
383372010865	GEF interaction site [polypeptide binding]; other site
383372010866	Rab family motif 2 (RabF2); other site
383372010867	G3 box; other site
383372010868	Switch II region; other site
383372010869	Rab family motif 3 (RabF3); other site
383372010870	Rab family motif 4 (RabF4); other site
383372010871	Rab family motif 5 (RabF5); other site
383372010872	Rab subfamily motif 3 (RabSF3); other site
383372010873	G4 box; other site
383372010874	G5 box; other site
383372010875	Response regulator receiver domain; Region: Response_reg; pfam00072
383372010876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372010877	active site
383372010878	phosphorylation site [posttranslational modification]
383372010879	intermolecular recognition site; other site
383372010880	dimerization interface [polypeptide binding]; other site
383372010881	PAS domain S-box; Region: sensory_box; TIGR00229
383372010882	GAF domain; Region: GAF_2; pfam13185
383372010883	GAF domain; Region: GAF; pfam01590
383372010884	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
383372010885	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
383372010886	Zn2+ binding site [ion binding]; other site
383372010887	Mg2+ binding site [ion binding]; other site
383372010888	Methyltransferase domain; Region: Methyltransf_31; pfam13847
383372010889	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372010890	S-adenosylmethionine binding site [chemical binding]; other site
383372010891	Thiamine pyrophosphokinase; Region: TPK; cd07995
383372010892	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
383372010893	active site
383372010894	dimerization interface [polypeptide binding]; other site
383372010895	thiamine binding site [chemical binding]; other site
383372010896	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
383372010897	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
383372010898	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
383372010899	Double zinc ribbon; Region: DZR; pfam12773
383372010900	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372010901	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372010902	phosphopeptide binding site; other site
383372010903	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372010904	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372010905	phosphopeptide binding site; other site
383372010906	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
383372010907	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
383372010908	Walker A/P-loop; other site
383372010909	ATP binding site [chemical binding]; other site
383372010910	Q-loop/lid; other site
383372010911	ABC transporter signature motif; other site
383372010912	Walker B; other site
383372010913	D-loop; other site
383372010914	H-loop/switch region; other site
383372010915	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
383372010916	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
383372010917	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372010918	Double zinc ribbon; Region: DZR; pfam12773
383372010919	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
383372010920	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
383372010921	phosphopeptide binding site; other site
383372010922	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
383372010923	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
383372010924	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
383372010925	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
383372010926	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
383372010927	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
383372010928	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
383372010929	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
383372010930	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
383372010931	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
383372010932	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
383372010933	NAD binding site [chemical binding]; other site
383372010934	ligand binding site [chemical binding]; other site
383372010935	catalytic site [active]
383372010936	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
383372010937	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
383372010938	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
383372010939	dimerization interface [polypeptide binding]; other site
383372010940	putative DNA binding site [nucleotide binding]; other site
383372010941	putative Zn2+ binding site [ion binding]; other site
383372010942	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
383372010943	Predicted permeases [General function prediction only]; Region: COG0701
383372010944	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
383372010945	Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO)-like family, N-terminal TRX-fold subdomain; composed of proteins with similarity to PfPDO, a redox active thermostable protein believed to be the archaeal counterpart of bacterial DsbA and...; Region: PfPDO_like_N; cd02975
383372010946	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
383372010947	catalytic residues [active]
383372010948	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
383372010949	catalytic residues [active]
383372010950	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
383372010951	H+ Antiporter protein; Region: 2A0121; TIGR00900
383372010952	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372010953	putative substrate translocation pore; other site
383372010954	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
383372010955	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
383372010956	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
383372010957	inhibitor-cofactor binding pocket; inhibition site
383372010958	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372010959	catalytic residue [active]
383372010960	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
383372010961	putative ligand binding pocket/active site [active]
383372010962	putative metal binding site [ion binding]; other site
383372010963	Bacterial SH3 domain; Region: SH3_3; pfam08239
383372010964	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
383372010965	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
383372010966	active site residue [active]
383372010967	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
383372010968	active site residue [active]
383372010969	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
383372010970	Protein of unknown function (DUF1641); Region: DUF1641; pfam07849
383372010971	Transcriptional regulator [Transcription]; Region: LysR; COG0583
383372010972	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
383372010973	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
383372010974	dimerization interface [polypeptide binding]; other site
383372010975	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
383372010976	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
383372010977	active site
383372010978	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372010979	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
383372010980	active site
383372010981	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372010982	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372010983	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372010984	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372010985	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372010986	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372010987	S-adenosylmethionine binding site [chemical binding]; other site
383372010988	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
383372010989	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
383372010990	Walker A/P-loop; other site
383372010991	ATP binding site [chemical binding]; other site
383372010992	Q-loop/lid; other site
383372010993	ABC transporter signature motif; other site
383372010994	Walker B; other site
383372010995	D-loop; other site
383372010996	H-loop/switch region; other site
383372010997	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
383372010998	putative carbohydrate binding site [chemical binding]; other site
383372010999	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372011000	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372011001	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372011002	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372011003	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
383372011004	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
383372011005	active site
383372011006	Methyltransferase domain; Region: Methyltransf_11; pfam08241
383372011007	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372011008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
383372011009	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372011010	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372011011	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372011012	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372011013	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
383372011014	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
383372011015	active site
383372011016	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
383372011017	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
383372011018	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
383372011019	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
383372011020	Probable transposase; Region: OrfB_IS605; pfam01385
383372011021	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
383372011022	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
383372011023	Protein of unknown function DUF86; Region: DUF86; pfam01934
383372011024	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372011025	active site
383372011026	NTP binding site [chemical binding]; other site
383372011027	metal binding triad [ion binding]; metal-binding site
383372011028	antibiotic binding site [chemical binding]; other site
383372011029	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372011030	putative active site [active]
383372011031	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
383372011032	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372011033	NAD(P) binding site [chemical binding]; other site
383372011034	active site
383372011035	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
383372011036	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372011037	active site
383372011038	phosphorylation site [posttranslational modification]
383372011039	intermolecular recognition site; other site
383372011040	dimerization interface [polypeptide binding]; other site
383372011041	ANTAR domain; Region: ANTAR; pfam03861
383372011042	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
383372011043	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
383372011044	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
383372011045	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372011046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372011047	active site
383372011048	phosphorylation site [posttranslational modification]
383372011049	intermolecular recognition site; other site
383372011050	dimerization interface [polypeptide binding]; other site
383372011051	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372011052	DNA binding site [nucleotide binding]
383372011053	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
383372011054	Rubrerythrin [Energy production and conversion]; Region: COG1592
383372011055	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
383372011056	dinuclear metal binding motif [ion binding]; other site
383372011057	metal-dependent hydrolase; Provisional; Region: PRK13291
383372011058	DinB superfamily; Region: DinB_2; pfam12867
383372011059	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372011060	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
383372011061	putative ADP-binding pocket [chemical binding]; other site
383372011062	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
383372011063	Chain length determinant protein; Region: Wzz; pfam02706
383372011064	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
383372011065	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
383372011066	Response regulator receiver domain; Region: Response_reg; pfam00072
383372011067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372011068	active site
383372011069	phosphorylation site [posttranslational modification]
383372011070	intermolecular recognition site; other site
383372011071	dimerization interface [polypeptide binding]; other site
383372011072	PAS domain; Region: PAS_9; pfam13426
383372011073	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372011074	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372011075	PAS domain S-box; Region: sensory_box; TIGR00229
383372011076	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372011077	dimer interface [polypeptide binding]; other site
383372011078	phosphorylation site [posttranslational modification]
383372011079	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372011080	ATP binding site [chemical binding]; other site
383372011081	Mg2+ binding site [ion binding]; other site
383372011082	G-X-G motif; other site
383372011083	Response regulator receiver domain; Region: Response_reg; pfam00072
383372011084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372011085	active site
383372011086	phosphorylation site [posttranslational modification]
383372011087	intermolecular recognition site; other site
383372011088	dimerization interface [polypeptide binding]; other site
383372011089	methionine gamma-lyase; Validated; Region: PRK07049
383372011090	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
383372011091	homodimer interface [polypeptide binding]; other site
383372011092	substrate-cofactor binding pocket; other site
383372011093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372011094	catalytic residue [active]
383372011095	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
383372011096	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
383372011097	active site
383372011098	metal binding site [ion binding]; metal-binding site
383372011099	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
383372011100	active site
383372011101	ATP binding site [chemical binding]; other site
383372011102	Bacterial PH domain; Region: DUF304; pfam03703
383372011103	GAF domain; Region: GAF_2; pfam13185
383372011104	GAF domain; Region: GAF_3; pfam13492
383372011105	Bacterial transcriptional activator domain; Region: BTAD; smart01043
383372011106	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
383372011107	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
383372011108	DNA binding residues [nucleotide binding]
383372011109	short chain dehydrogenase; Provisional; Region: PRK06197
383372011110	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
383372011111	putative NAD(P) binding site [chemical binding]; other site
383372011112	active site
383372011113	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
383372011114	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
383372011115	ligand binding site [chemical binding]; other site
383372011116	flexible hinge region; other site
383372011117	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
383372011118	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
383372011119	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372011120	Coenzyme A binding pocket [chemical binding]; other site
383372011121	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
383372011122	active site
383372011123	catalytic site [active]
383372011124	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
383372011125	Peptidase family M50; Region: Peptidase_M50; pfam02163
383372011126	active site
383372011127	putative substrate binding region [chemical binding]; other site
383372011128	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992
383372011129	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
383372011130	active site
383372011131	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
383372011132	putative trimer interface [polypeptide binding]; other site
383372011133	putative CoA binding site [chemical binding]; other site
383372011134	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
383372011135	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
383372011136	putative active site [active]
383372011137	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372011138	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
383372011139	DNA methylase; Region: N6_N4_Mtase; pfam01555
383372011140	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
383372011141	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
383372011142	Bacterial transcriptional activator domain; Region: BTAD; smart01043
383372011143	Predicted ATPase [General function prediction only]; Region: COG3903
383372011144	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372011145	binding surface
383372011146	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011147	TPR motif; other site
383372011148	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011149	Transposase IS200 like; Region: Y1_Tnp; pfam01797
383372011150	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
383372011151	Ca2+ binding site [ion binding]; other site
383372011152	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
383372011153	PA14 domain; Region: PA14; cl08459
383372011154	Mo-co oxidoreductase dimerisation domain; Region: Mo-co_dimer; pfam03404
383372011155	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
383372011156	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
383372011157	CHAT domain; Region: CHAT; cl17868
383372011158	AAA ATPase domain; Region: AAA_16; pfam13191
383372011159	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011160	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011161	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011162	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011163	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011164	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011165	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011166	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011167	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011168	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011169	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011170	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372011171	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
383372011172	active site
383372011173	Ap6A binding site [chemical binding]; other site
383372011174	nudix motif; other site
383372011175	metal binding site [ion binding]; metal-binding site
383372011176	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
383372011177	dimer interface [polypeptide binding]; other site
383372011178	substrate binding site [chemical binding]; other site
383372011179	metal binding sites [ion binding]; metal-binding site
383372011180	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372011181	Double zinc ribbon; Region: DZR; pfam12773
383372011182	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
383372011183	transcription termination factor Rho; Provisional; Region: rho; PRK09376
383372011184	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
383372011185	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
383372011186	RNA binding site [nucleotide binding]; other site
383372011187	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
383372011188	multimer interface [polypeptide binding]; other site
383372011189	Walker A motif; other site
383372011190	ATP binding site [chemical binding]; other site
383372011191	Walker B motif; other site
383372011192	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
383372011193	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
383372011194	motif 1; other site
383372011195	active site
383372011196	motif 2; other site
383372011197	motif 3; other site
383372011198	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
383372011199	DHHA1 domain; Region: DHHA1; pfam02272
383372011200	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
383372011201	AAA domain; Region: AAA_33; pfam13671
383372011202	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
383372011203	active site
383372011204	Rossmann-like domain; Region: Rossmann-like; pfam10727
383372011205	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
383372011206	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
383372011207	putative active site pocket [active]
383372011208	cleavage site
383372011209	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
383372011210	Thioredoxin; Region: Thioredoxin_4; pfam13462
383372011211	Double zinc ribbon; Region: DZR; pfam12773
383372011212	Protein of unknown function (DUF970); Region: DUF970; cl17525
383372011213	thymidylate kinase; Validated; Region: tmk; PRK00698
383372011214	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
383372011215	TMP-binding site; other site
383372011216	ATP-binding site [chemical binding]; other site
383372011217	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
383372011218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372011219	Walker A motif; other site
383372011220	ATP binding site [chemical binding]; other site
383372011221	Walker B motif; other site
383372011222	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
383372011223	RxxxH motif; other site
383372011224	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
383372011225	predicted active site [active]
383372011226	catalytic triad [active]
383372011227	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
383372011228	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
383372011229	active site
383372011230	multimer interface [polypeptide binding]; other site
383372011231	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
383372011232	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
383372011233	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
383372011234	Predicted transcriptional regulator [Transcription]; Region: COG2345
383372011235	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
383372011236	dimerization interface [polypeptide binding]; other site
383372011237	putative DNA binding site [nucleotide binding]; other site
383372011238	putative Zn2+ binding site [ion binding]; other site
383372011239	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
383372011240	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372011241	NAD(P) binding site [chemical binding]; other site
383372011242	active site
383372011243	hypothetical protein; Validated; Region: PRK07682
383372011244	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
383372011245	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372011246	homodimer interface [polypeptide binding]; other site
383372011247	catalytic residue [active]
383372011248	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
383372011249	Ligand binding site; other site
383372011250	Putative Catalytic site; other site
383372011251	DXD motif; other site
383372011252	Dehydroquinase class II; Region: DHquinase_II; pfam01220
383372011253	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
383372011254	trimer interface [polypeptide binding]; other site
383372011255	active site
383372011256	dimer interface [polypeptide binding]; other site
383372011257	Right handed beta helix region; Region: Beta_helix; pfam13229
383372011258	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
383372011259	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
383372011260	Right handed beta helix region; Region: Beta_helix; pfam13229
383372011261	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
383372011262	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
383372011263	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
383372011264	nucleotide binding site [chemical binding]; other site
383372011265	NEF interaction site [polypeptide binding]; other site
383372011266	SBD interface [polypeptide binding]; other site
383372011267	Colicin V production protein; Region: Colicin_V; pfam02674
383372011268	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
383372011269	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
383372011270	CoA binding domain; Region: CoA_binding; smart00881
383372011271	CoA-ligase; Region: Ligase_CoA; pfam00549
383372011272	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
383372011273	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
383372011274	catalytic residue [active]
383372011275	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
383372011276	Low molecular weight phosphatase family; Region: LMWPc; cd00115
383372011277	active site
383372011278	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
383372011279	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
383372011280	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
383372011281	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
383372011282	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
383372011283	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
383372011284	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
383372011285	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
383372011286	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
383372011287	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
383372011288	putative NAD(P) binding site [chemical binding]; other site
383372011289	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
383372011290	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
383372011291	Ligand Binding Site [chemical binding]; other site
383372011292	Protein of unknown function (DUF3623); Region: DUF3623; pfam12291
383372011293	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
383372011294	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
383372011295	UbiA prenyltransferase family; Region: UbiA; pfam01040
383372011296	Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224
383372011297	subunit interface [polypeptide binding]; other site
383372011298	Heme binding sites [chemical binding]; other site
383372011299	bifunctional photosynthetic reaction center subunit L/M; Provisional; Region: PRK14505
383372011300	Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290
383372011301	subunit M interface; other site
383372011302	subunit H interface; other site
383372011303	quinone binding site; other site
383372011304	bacteriopheophytin binding site; other site
383372011305	bacteriochlorophyll binding site; other site
383372011306	cytochrome C subunit interface; other site
383372011307	Fe binding site [ion binding]; other site
383372011308	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
383372011309	pheophytin binding site; other site
383372011310	chlorophyll binding site; other site
383372011311	quinone binding site; other site
383372011312	Fe binding site [ion binding]; other site
383372011313	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
383372011314	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
383372011315	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
383372011316	DNA binding residues [nucleotide binding]
383372011317	B12 binding domain; Region: B12-binding_2; pfam02607
383372011318	B12 binding domain; Region: B12-binding; pfam02310
383372011319	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
383372011320	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
383372011321	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
383372011322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
383372011323	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
383372011324	Uncharacterized conserved protein [Function unknown]; Region: COG2308
383372011325	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
383372011326	Histidine kinase; Region: HisKA_3; pfam07730
383372011327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372011328	ATP binding site [chemical binding]; other site
383372011329	Mg2+ binding site [ion binding]; other site
383372011330	G-X-G motif; other site
383372011331	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372011332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372011333	active site
383372011334	phosphorylation site [posttranslational modification]
383372011335	intermolecular recognition site; other site
383372011336	dimerization interface [polypeptide binding]; other site
383372011337	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372011338	DNA binding residues [nucleotide binding]
383372011339	dimerization interface [polypeptide binding]; other site
383372011340	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
383372011341	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
383372011342	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
383372011343	substrate binding site [chemical binding]; other site
383372011344	dimer interface [polypeptide binding]; other site
383372011345	ATP binding site [chemical binding]; other site
383372011346	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
383372011347	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372011348	motif II; other site
383372011349	LrgA family; Region: LrgA; pfam03788
383372011350	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
383372011351	classical (c) SDRs; Region: SDR_c; cd05233
383372011352	NAD(P) binding site [chemical binding]; other site
383372011353	active site
383372011354	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
383372011355	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
383372011356	homodimer interface [polypeptide binding]; other site
383372011357	active site
383372011358	TDP-binding site; other site
383372011359	acceptor substrate-binding pocket; other site
383372011360	oxidative damage protection protein; Provisional; Region: PRK05408
383372011361	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
383372011362	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
383372011363	hexamer interface [polypeptide binding]; other site
383372011364	ligand binding site [chemical binding]; other site
383372011365	putative active site [active]
383372011366	NAD(P) binding site [chemical binding]; other site
383372011367	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
383372011368	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
383372011369	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
383372011370	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
383372011371	Ligand Binding Site [chemical binding]; other site
383372011372	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
383372011373	Ligand Binding Site [chemical binding]; other site
383372011374	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
383372011375	Ligand Binding Site [chemical binding]; other site
383372011376	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
383372011377	Ligand Binding Site [chemical binding]; other site
383372011378	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
383372011379	Ligand Binding Site [chemical binding]; other site
383372011380	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
383372011381	FOG: CBS domain [General function prediction only]; Region: COG0517
383372011382	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
383372011383	FOG: CBS domain [General function prediction only]; Region: COG0517
383372011384	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
383372011385	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
383372011386	active site
383372011387	diiron metal binding site [ion binding]; other site
383372011388	Transcriptional regulator [Transcription]; Region: LysR; COG0583
383372011389	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
383372011390	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
383372011391	dimerization interface [polypeptide binding]; other site
383372011392	calcium/proton exchanger (cax); Region: cax; TIGR00378
383372011393	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
383372011394	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
383372011395	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
383372011396	dimerization interface [polypeptide binding]; other site
383372011397	putative active cleft [active]
383372011398	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
383372011399	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
383372011400	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
383372011401	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
383372011402	dimer interface [polypeptide binding]; other site
383372011403	anticodon binding site; other site
383372011404	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
383372011405	homodimer interface [polypeptide binding]; other site
383372011406	motif 1; other site
383372011407	active site
383372011408	motif 2; other site
383372011409	GAD domain; Region: GAD; pfam02938
383372011410	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
383372011411	active site
383372011412	motif 3; other site
383372011413	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
383372011414	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
383372011415	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372011416	putative active site [active]
383372011417	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372011418	putative active site [active]
383372011419	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
383372011420	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
383372011421	[2Fe-2S] cluster binding site [ion binding]; other site
383372011422	C-terminal catalytic domain of plant choline monooxygenase (CMO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_CMO-like; cd08883
383372011423	putative alpha subunit interface [polypeptide binding]; other site
383372011424	putative active site [active]
383372011425	putative substrate binding site [chemical binding]; other site
383372011426	Fe binding site [ion binding]; other site
383372011427	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
383372011428	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
383372011429	dimerization interface [polypeptide binding]; other site
383372011430	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
383372011431	ATP binding site [chemical binding]; other site
383372011432	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
383372011433	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
383372011434	HupF/HypC family; Region: HupF_HypC; pfam01455
383372011435	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
383372011436	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
383372011437	iron-sulfur cluster [ion binding]; other site
383372011438	[2Fe-2S] cluster binding site [ion binding]; other site
383372011439	This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063
383372011440	nickel binding site [ion binding]; other site
383372011441	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
383372011442	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
383372011443	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
383372011444	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
383372011445	Protein of unknown function (DUF1641); Region: DUF1641; pfam07849
383372011446	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
383372011447	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
383372011448	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
383372011449	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
383372011450	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
383372011451	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
383372011452	active site
383372011453	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
383372011454	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
383372011455	inhibitor-cofactor binding pocket; inhibition site
383372011456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372011457	catalytic residue [active]
383372011458	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372011459	MoxR-like ATPases [General function prediction only]; Region: COG0714
383372011460	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372011461	Walker A motif; other site
383372011462	ATP binding site [chemical binding]; other site
383372011463	Walker B motif; other site
383372011464	arginine finger; other site
383372011465	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
383372011466	Protein of unknown function DUF58; Region: DUF58; pfam01882
383372011467	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
383372011468	von Willebrand factor type A domain; Region: VWA_2; pfam13519
383372011469	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372011470	metal ion-dependent adhesion site (MIDAS); other site
383372011471	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
383372011472	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
383372011473	metal ion-dependent adhesion site (MIDAS); other site
383372011474	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
383372011475	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
383372011476	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
383372011477	Phosphotransferase enzyme family; Region: APH; pfam01636
383372011478	active site
383372011479	substrate binding site [chemical binding]; other site
383372011480	ATP binding site [chemical binding]; other site
383372011481	FOG: CBS domain [General function prediction only]; Region: COG0517
383372011482	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
383372011483	FOG: CBS domain [General function prediction only]; Region: COG0517
383372011484	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372011485	GAF domain; Region: GAF_3; pfam13492
383372011486	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372011487	dimer interface [polypeptide binding]; other site
383372011488	phosphorylation site [posttranslational modification]
383372011489	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372011490	ATP binding site [chemical binding]; other site
383372011491	Mg2+ binding site [ion binding]; other site
383372011492	G-X-G motif; other site
383372011493	Response regulator receiver domain; Region: Response_reg; pfam00072
383372011494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372011495	active site
383372011496	phosphorylation site [posttranslational modification]
383372011497	intermolecular recognition site; other site
383372011498	dimerization interface [polypeptide binding]; other site
383372011499	shikimate kinase; Reviewed; Region: aroK; PRK00131
383372011500	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
383372011501	active site
383372011502	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
383372011503	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
383372011504	acyl-activating enzyme (AAE) consensus motif; other site
383372011505	putative AMP binding site [chemical binding]; other site
383372011506	putative active site [active]
383372011507	putative CoA binding site [chemical binding]; other site
383372011508	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
383372011509	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
383372011510	Tetramer interface [polypeptide binding]; other site
383372011511	active site
383372011512	FMN-binding site [chemical binding]; other site
383372011513	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372011514	TPR repeat; Region: TPR_11; pfam13414
383372011515	binding surface
383372011516	TPR motif; other site
383372011517	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
383372011518	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
383372011519	active site
383372011520	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372011521	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372011522	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372011523	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372011524	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372011525	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372011526	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
383372011527	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
383372011528	metal binding site [ion binding]; metal-binding site
383372011529	active site
383372011530	I-site; other site
383372011531	Transglycosylase; Region: Transgly; pfam00912
383372011532	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
383372011533	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
383372011534	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
383372011535	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
383372011536	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
383372011537	DNA binding site [nucleotide binding]
383372011538	catalytic residue [active]
383372011539	H2TH interface [polypeptide binding]; other site
383372011540	putative catalytic residues [active]
383372011541	turnover-facilitating residue; other site
383372011542	intercalation triad [nucleotide binding]; other site
383372011543	8OG recognition residue [nucleotide binding]; other site
383372011544	putative reading head residues; other site
383372011545	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
383372011546	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
383372011547	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
383372011548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372011549	dimer interface [polypeptide binding]; other site
383372011550	conserved gate region; other site
383372011551	putative PBP binding loops; other site
383372011552	ABC-ATPase subunit interface; other site
383372011553	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
383372011554	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372011555	dimer interface [polypeptide binding]; other site
383372011556	conserved gate region; other site
383372011557	putative PBP binding loops; other site
383372011558	ABC-ATPase subunit interface; other site
383372011559	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
383372011560	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
383372011561	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
383372011562	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
383372011563	inhibitor-cofactor binding pocket; inhibition site
383372011564	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372011565	catalytic residue [active]
383372011566	Transcriptional regulators [Transcription]; Region: GntR; COG1802
383372011567	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
383372011568	DNA-binding site [nucleotide binding]; DNA binding site
383372011569	FCD domain; Region: FCD; pfam07729
383372011570	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
383372011571	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
383372011572	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
383372011573	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372011574	dimer interface [polypeptide binding]; other site
383372011575	conserved gate region; other site
383372011576	putative PBP binding loops; other site
383372011577	ABC-ATPase subunit interface; other site
383372011578	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
383372011579	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
383372011580	dimer interface [polypeptide binding]; other site
383372011581	conserved gate region; other site
383372011582	putative PBP binding loops; other site
383372011583	ABC-ATPase subunit interface; other site
383372011584	galactonate dehydratase; Provisional; Region: PRK14017
383372011585	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
383372011586	metal binding site [ion binding]; metal-binding site
383372011587	substrate binding pocket [chemical binding]; other site
383372011588	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
383372011589	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
383372011590	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
383372011591	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
383372011592	classical (c) SDRs; Region: SDR_c; cd05233
383372011593	NAD(P) binding site [chemical binding]; other site
383372011594	active site
383372011595	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
383372011596	DNA-binding site [nucleotide binding]; DNA binding site
383372011597	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
383372011598	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
383372011599	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
383372011600	putative active site [active]
383372011601	Zn binding site [ion binding]; other site
383372011602	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
383372011603	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
383372011604	active site pocket [active]
383372011605	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372011606	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372011607	dimerization interface [polypeptide binding]; other site
383372011608	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372011609	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
383372011610	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
383372011611	Nuclease-related domain; Region: NERD; pfam08378
383372011612	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
383372011613	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
383372011614	active site
383372011615	catalytic site [active]
383372011616	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
383372011617	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372011618	putative active site [active]
383372011619	BtpA family; Region: BtpA; cl00440
383372011620	pteridine reductase; Provisional; Region: PRK09135
383372011621	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372011622	NAD(P) binding site [chemical binding]; other site
383372011623	active site
383372011624	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
383372011625	trimer interface [polypeptide binding]; other site
383372011626	dimer interface [polypeptide binding]; other site
383372011627	putative active site [active]
383372011628	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
383372011629	heterodimer interface [polypeptide binding]; other site
383372011630	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
383372011631	substrate interaction site [chemical binding]; other site
383372011632	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
383372011633	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
383372011634	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
383372011635	active site
383372011636	substrate binding site [chemical binding]; other site
383372011637	coenzyme B12 binding site [chemical binding]; other site
383372011638	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
383372011639	B12 binding site [chemical binding]; other site
383372011640	cobalt ligand [ion binding]; other site
383372011641	membrane ATPase/protein kinase; Provisional; Region: PRK09435
383372011642	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
383372011643	GTP/Mg2+ binding site [chemical binding]; other site
383372011644	G5 box; other site
383372011645	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
383372011646	Walker A; other site
383372011647	G1 box; other site
383372011648	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
383372011649	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
383372011650	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
383372011651	FeoA domain; Region: FeoA; pfam04023
383372011652	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
383372011653	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
383372011654	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
383372011655	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
383372011656	substrate binding pocket [chemical binding]; other site
383372011657	dimer interface [polypeptide binding]; other site
383372011658	inhibitor binding site; inhibition site
383372011659	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
383372011660	B12 binding site [chemical binding]; other site
383372011661	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
383372011662	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
383372011663	intersubunit interface [polypeptide binding]; other site
383372011664	active site
383372011665	Zn2+ binding site [ion binding]; other site
383372011666	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
383372011667	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372011668	NAD(P) binding site [chemical binding]; other site
383372011669	active site
383372011670	B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034
383372011671	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
383372011672	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372011673	PAS domain; Region: PAS_9; pfam13426
383372011674	putative active site [active]
383372011675	heme pocket [chemical binding]; other site
383372011676	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372011677	PAS fold; Region: PAS_3; pfam08447
383372011678	putative active site [active]
383372011679	heme pocket [chemical binding]; other site
383372011680	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372011681	dimer interface [polypeptide binding]; other site
383372011682	phosphorylation site [posttranslational modification]
383372011683	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372011684	ATP binding site [chemical binding]; other site
383372011685	Mg2+ binding site [ion binding]; other site
383372011686	G-X-G motif; other site
383372011687	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
383372011688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372011689	active site
383372011690	phosphorylation site [posttranslational modification]
383372011691	intermolecular recognition site; other site
383372011692	dimerization interface [polypeptide binding]; other site
383372011693	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372011694	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372011695	Predicted membrane protein [Function unknown]; Region: COG3463
383372011696	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
383372011697	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
383372011698	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372011699	TPR motif; other site
383372011700	binding surface
383372011701	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131
383372011702	Methyltransferase domain; Region: Methyltransf_23; pfam13489
383372011703	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372011704	S-adenosylmethionine binding site [chemical binding]; other site
383372011705	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372011706	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372011707	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372011708	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372011709	Predicted permease; Region: DUF318; cl17795
383372011710	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
383372011711	metal binding site 2 [ion binding]; metal-binding site
383372011712	putative DNA binding helix; other site
383372011713	metal binding site 1 [ion binding]; metal-binding site
383372011714	dimer interface [polypeptide binding]; other site
383372011715	structural Zn2+ binding site [ion binding]; other site
383372011716	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
383372011717	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
383372011718	ligand binding site [chemical binding]; other site
383372011719	flexible hinge region; other site
383372011720	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
383372011721	putative switch regulator; other site
383372011722	non-specific DNA interactions [nucleotide binding]; other site
383372011723	DNA binding site [nucleotide binding]
383372011724	sequence specific DNA binding site [nucleotide binding]; other site
383372011725	putative cAMP binding site [chemical binding]; other site
383372011726	Probable zinc-binding domain; Region: zf-trcl; pfam13451
383372011727	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
383372011728	RNA binding site [nucleotide binding]; other site
383372011729	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
383372011730	metal binding site 2 [ion binding]; metal-binding site
383372011731	putative DNA binding helix; other site
383372011732	metal binding site 1 [ion binding]; metal-binding site
383372011733	dimer interface [polypeptide binding]; other site
383372011734	structural Zn2+ binding site [ion binding]; other site
383372011735	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
383372011736	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
383372011737	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
383372011738	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372011739	NAD(P) binding site [chemical binding]; other site
383372011740	active site
383372011741	ornithine cyclodeaminase; Validated; Region: PRK08618
383372011742	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
383372011743	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
383372011744	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
383372011745	ligand binding site [chemical binding]; other site
383372011746	flexible hinge region; other site
383372011747	D-mannonate oxidoreductase; Provisional; Region: PRK08277
383372011748	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372011749	NAD(P) binding site [chemical binding]; other site
383372011750	active site
383372011751	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
383372011752	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
383372011753	active site
383372011754	catalytic site [active]
383372011755	HEAT repeats; Region: HEAT_2; pfam13646
383372011756	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372011757	active site
383372011758	NTP binding site [chemical binding]; other site
383372011759	metal binding triad [ion binding]; metal-binding site
383372011760	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701
383372011761	HEPN domain; Region: HEPN; pfam05168
383372011762	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372011763	active site
383372011764	NTP binding site [chemical binding]; other site
383372011765	metal binding triad [ion binding]; metal-binding site
383372011766	antibiotic binding site [chemical binding]; other site
383372011767	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
383372011768	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
383372011769	rRNA interaction site [nucleotide binding]; other site
383372011770	S8 interaction site; other site
383372011771	putative laminin-1 binding site; other site
383372011772	elongation factor Ts; Reviewed; Region: tsf; PRK12332
383372011773	UBA/TS-N domain; Region: UBA; pfam00627
383372011774	Elongation factor TS; Region: EF_TS; pfam00889
383372011775	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
383372011776	putative nucleotide binding site [chemical binding]; other site
383372011777	uridine monophosphate binding site [chemical binding]; other site
383372011778	homohexameric interface [polypeptide binding]; other site
383372011779	ribosome recycling factor; Reviewed; Region: frr; PRK00083
383372011780	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
383372011781	hinge region; other site
383372011782	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
383372011783	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
383372011784	catalytic residue [active]
383372011785	putative FPP diphosphate  binding site; other site
383372011786	putative FPP binding hydrophobic cleft; other site
383372011787	dimer interface [polypeptide binding]; other site
383372011788	putative IPP diphosphate binding site; other site
383372011789	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
383372011790	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
383372011791	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
383372011792	DHH family; Region: DHH; pfam01368
383372011793	DHHA1 domain; Region: DHHA1; pfam02272
383372011794	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
383372011795	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
383372011796	ligand binding site [chemical binding]; other site
383372011797	flexible hinge region; other site
383372011798	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
383372011799	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
383372011800	metal binding triad; other site
383372011801	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
383372011802	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
383372011803	active site
383372011804	catalytic site [active]
383372011805	substrate binding site [chemical binding]; other site
383372011806	acetyl-CoA synthetase; Provisional; Region: PRK00174
383372011807	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
383372011808	active site
383372011809	CoA binding site [chemical binding]; other site
383372011810	acyl-activating enzyme (AAE) consensus motif; other site
383372011811	AMP binding site [chemical binding]; other site
383372011812	acetate binding site [chemical binding]; other site
383372011813	acetyl-CoA synthetase; Provisional; Region: PRK00174
383372011814	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
383372011815	active site
383372011816	CoA binding site [chemical binding]; other site
383372011817	acyl-activating enzyme (AAE) consensus motif; other site
383372011818	AMP binding site [chemical binding]; other site
383372011819	acetate binding site [chemical binding]; other site
383372011820	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
383372011821	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372011822	Coenzyme A binding pocket [chemical binding]; other site
383372011823	ribonuclease PH; Reviewed; Region: rph; PRK00173
383372011824	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
383372011825	oligomer interface [polypeptide binding]; other site
383372011826	RNA binding site [nucleotide binding]; other site
383372011827	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
383372011828	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372011829	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372011830	Bacterial Ig-like domain; Region: Big_5; pfam13205
383372011831	MG2 domain; Region: A2M_N; pfam01835
383372011832	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
383372011833	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
383372011834	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372011835	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372011836	S-adenosylmethionine binding site [chemical binding]; other site
383372011837	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
383372011838	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372011839	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
383372011840	active site
383372011841	catalytic residues [active]
383372011842	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
383372011843	AsnC family; Region: AsnC_trans_reg; pfam01037
383372011844	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
383372011845	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
383372011846	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
383372011847	GatB domain; Region: GatB_Yqey; smart00845
383372011848	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
383372011849	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
383372011850	Putative esterase; Region: Esterase; pfam00756
383372011851	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
383372011852	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
383372011853	Walker A/P-loop; other site
383372011854	ATP binding site [chemical binding]; other site
383372011855	Q-loop/lid; other site
383372011856	ABC transporter signature motif; other site
383372011857	Walker B; other site
383372011858	D-loop; other site
383372011859	H-loop/switch region; other site
383372011860	Predicted periplasmic protein [Function unknown]; Region: COG3698
383372011861	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
383372011862	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
383372011863	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
383372011864	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
383372011865	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
383372011866	ATP binding site [chemical binding]; other site
383372011867	Mg2+ binding site [ion binding]; other site
383372011868	G-X-G motif; other site
383372011869	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
383372011870	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
383372011871	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
383372011872	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
383372011873	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
383372011874	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
383372011875	protein binding site [polypeptide binding]; other site
383372011876	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
383372011877	Domain interface; other site
383372011878	Peptide binding site; other site
383372011879	Active site tetrad [active]
383372011880	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
383372011881	putative active site pocket [active]
383372011882	4-fold oligomerization interface [polypeptide binding]; other site
383372011883	metal binding residues [ion binding]; metal-binding site
383372011884	3-fold/trimer interface [polypeptide binding]; other site
383372011885	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
383372011886	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
383372011887	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372011888	active site
383372011889	NTP binding site [chemical binding]; other site
383372011890	metal binding triad [ion binding]; metal-binding site
383372011891	antibiotic binding site [chemical binding]; other site
383372011892	Protein of unknown function DUF86; Region: DUF86; cl01031
383372011893	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110
383372011894	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
383372011895	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
383372011896	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
383372011897	classical (c) SDRs; Region: SDR_c; cd05233
383372011898	NAD(P) binding site [chemical binding]; other site
383372011899	active site
383372011900	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
383372011901	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
383372011902	acyl-activating enzyme (AAE) consensus motif; other site
383372011903	active site
383372011904	AMP binding site [chemical binding]; other site
383372011905	CoA binding site [chemical binding]; other site
383372011906	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931
383372011907	putative active site [active]
383372011908	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
383372011909	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
383372011910	putative trimer interface [polypeptide binding]; other site
383372011911	putative CoA binding site [chemical binding]; other site
383372011912	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
383372011913	trimer interface [polypeptide binding]; other site
383372011914	active site
383372011915	substrate binding site [chemical binding]; other site
383372011916	CoA binding site [chemical binding]; other site
383372011917	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
383372011918	Ligand binding site; other site
383372011919	Putative Catalytic site; other site
383372011920	DXD motif; other site
383372011921	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
383372011922	active site
383372011923	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
383372011924	homodimer interface [polypeptide binding]; other site
383372011925	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
383372011926	hypothetical protein; Provisional; Region: PRK07233
383372011927	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
383372011928	Bacterial sugar transferase; Region: Bac_transf; pfam02397
383372011929	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372011930	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372011931	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
383372011932	GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478
383372011933	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
383372011934	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
383372011935	putative FMN binding site [chemical binding]; other site
383372011936	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
383372011937	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
383372011938	phosphate binding site [ion binding]; other site
383372011939	dimer interface [polypeptide binding]; other site
383372011940	substrate binding site [chemical binding]; other site
383372011941	2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552
383372011942	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
383372011943	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
383372011944	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
383372011945	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
383372011946	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
383372011947	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
383372011948	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
383372011949	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
383372011950	YbbR-like protein; Region: YbbR; pfam07949
383372011951	Uncharacterized conserved protein [Function unknown]; Region: COG1624
383372011952	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
383372011953	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372011954	TPR motif; other site
383372011955	binding surface
383372011956	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372011957	binding surface
383372011958	TPR motif; other site
383372011959	TPR repeat; Region: TPR_11; pfam13414
383372011960	TPR repeat; Region: TPR_11; pfam13414
383372011961	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372011962	TPR motif; other site
383372011963	binding surface
383372011964	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
383372011965	binding surface
383372011966	TPR motif; other site
383372011967	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372011968	binding surface
383372011969	TPR motif; other site
383372011970	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
383372011971	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372011972	Walker A motif; other site
383372011973	ATP binding site [chemical binding]; other site
383372011974	Walker B motif; other site
383372011975	arginine finger; other site
383372011976	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
383372011977	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
383372011978	replicative DNA helicase; Region: DnaB; TIGR00665
383372011979	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
383372011980	Walker A motif; other site
383372011981	ATP binding site [chemical binding]; other site
383372011982	Walker B motif; other site
383372011983	DNA binding loops [nucleotide binding]
383372011984	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
383372011985	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
383372011986	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
383372011987	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
383372011988	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372011989	motif II; other site
383372011990	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
383372011991	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
383372011992	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
383372011993	active site
383372011994	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
383372011995	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
383372011996	23S rRNA interface [nucleotide binding]; other site
383372011997	L3 interface [polypeptide binding]; other site
383372011998	tRNA pseudouridine synthase ACD; Provisional; Region: PRK14588
383372011999	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
383372012000	dimerization interface 3.5A [polypeptide binding]; other site
383372012001	active site
383372012002	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
383372012003	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
383372012004	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
383372012005	alphaNTD homodimer interface [polypeptide binding]; other site
383372012006	alphaNTD - beta interaction site [polypeptide binding]; other site
383372012007	alphaNTD - beta' interaction site [polypeptide binding]; other site
383372012008	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
383372012009	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
383372012010	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
383372012011	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
383372012012	RNA binding surface [nucleotide binding]; other site
383372012013	30S ribosomal protein S11; Validated; Region: PRK05309
383372012014	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
383372012015	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
383372012016	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
383372012017	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
383372012018	rRNA binding site [nucleotide binding]; other site
383372012019	predicted 30S ribosome binding site; other site
383372012020	adenylate kinase; Reviewed; Region: adk; PRK00279
383372012021	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
383372012022	AMP-binding site [chemical binding]; other site
383372012023	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
383372012024	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
383372012025	SecY translocase; Region: SecY; pfam00344
383372012026	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
383372012027	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
383372012028	23S rRNA binding site [nucleotide binding]; other site
383372012029	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
383372012030	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
383372012031	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
383372012032	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
383372012033	5S rRNA interface [nucleotide binding]; other site
383372012034	L27 interface [polypeptide binding]; other site
383372012035	23S rRNA interface [nucleotide binding]; other site
383372012036	L5 interface [polypeptide binding]; other site
383372012037	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
383372012038	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
383372012039	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
383372012040	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
383372012041	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
383372012042	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
383372012043	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
383372012044	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
383372012045	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
383372012046	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
383372012047	RNA binding site [nucleotide binding]; other site
383372012048	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
383372012049	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
383372012050	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
383372012051	putative translocon interaction site; other site
383372012052	23S rRNA interface [nucleotide binding]; other site
383372012053	signal recognition particle (SRP54) interaction site; other site
383372012054	L23 interface [polypeptide binding]; other site
383372012055	trigger factor interaction site; other site
383372012056	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
383372012057	23S rRNA interface [nucleotide binding]; other site
383372012058	5S rRNA interface [nucleotide binding]; other site
383372012059	putative antibiotic binding site [chemical binding]; other site
383372012060	L25 interface [polypeptide binding]; other site
383372012061	L27 interface [polypeptide binding]; other site
383372012062	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
383372012063	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
383372012064	G-X-X-G motif; other site
383372012065	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
383372012066	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
383372012067	putative translocon binding site; other site
383372012068	protein-rRNA interface [nucleotide binding]; other site
383372012069	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
383372012070	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
383372012071	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
383372012072	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
383372012073	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
383372012074	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
383372012075	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
383372012076	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
383372012077	elongation factor Tu; Reviewed; Region: PRK00049
383372012078	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
383372012079	G1 box; other site
383372012080	GEF interaction site [polypeptide binding]; other site
383372012081	GTP/Mg2+ binding site [chemical binding]; other site
383372012082	Switch I region; other site
383372012083	G2 box; other site
383372012084	G3 box; other site
383372012085	Switch II region; other site
383372012086	G4 box; other site
383372012087	G5 box; other site
383372012088	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
383372012089	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
383372012090	Antibiotic Binding Site [chemical binding]; other site
383372012091	elongation factor G; Reviewed; Region: PRK00007
383372012092	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
383372012093	G1 box; other site
383372012094	putative GEF interaction site [polypeptide binding]; other site
383372012095	GTP/Mg2+ binding site [chemical binding]; other site
383372012096	Switch I region; other site
383372012097	G2 box; other site
383372012098	G3 box; other site
383372012099	Switch II region; other site
383372012100	G4 box; other site
383372012101	G5 box; other site
383372012102	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
383372012103	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
383372012104	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
383372012105	30S ribosomal protein S7; Validated; Region: PRK05302
383372012106	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
383372012107	S17 interaction site [polypeptide binding]; other site
383372012108	S8 interaction site; other site
383372012109	16S rRNA interaction site [nucleotide binding]; other site
383372012110	streptomycin interaction site [chemical binding]; other site
383372012111	23S rRNA interaction site [nucleotide binding]; other site
383372012112	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
383372012113	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
383372012114	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
383372012115	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
383372012116	NgoMIV restriction enzyme; Region: NgoMIV_restric; pfam09015
383372012117	DNA methylase; Region: N6_N4_Mtase; pfam01555
383372012118	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
383372012119	Nitrogenase_MoFe_beta_like: Nitrogenase MoFe protein, beta subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen (N2) to ammonia.  This group contains the beta subunits of component 1 of the three known genetically...; Region: Nitrogenase_MoFe_beta_like; cd01965
383372012120	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
383372012121	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
383372012122	Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967
383372012123	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372012124	Radical SAM superfamily; Region: Radical_SAM; pfam04055
383372012125	FeS/SAM binding site; other site
383372012126	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
383372012127	nitrogenase iron protein; Region: nifH; TIGR01287
383372012128	Nucleotide-binding sites [chemical binding]; other site
383372012129	Walker A motif; other site
383372012130	Switch I region of nucleotide binding site; other site
383372012131	Fe4S4 binding sites [ion binding]; other site
383372012132	Switch II region of nucleotide binding site; other site
383372012133	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
383372012134	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
383372012135	FtsX-like permease family; Region: FtsX; pfam02687
383372012136	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181
383372012137	active site
383372012138	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372012139	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
383372012140	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
383372012141	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
383372012142	dimer interface [polypeptide binding]; other site
383372012143	PYR/PP interface [polypeptide binding]; other site
383372012144	TPP binding site [chemical binding]; other site
383372012145	substrate binding site [chemical binding]; other site
383372012146	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
383372012147	Domain of unknown function; Region: EKR; smart00890
383372012148	4Fe-4S binding domain; Region: Fer4_6; pfam12837
383372012149	4Fe-4S binding domain; Region: Fer4; pfam00037
383372012150	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
383372012151	TPP-binding site [chemical binding]; other site
383372012152	dimer interface [polypeptide binding]; other site
383372012153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372012154	Major Facilitator Superfamily; Region: MFS_1; pfam07690
383372012155	putative substrate translocation pore; other site
383372012156	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
383372012157	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
383372012158	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
383372012159	putative active site [active]
383372012160	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
383372012161	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
383372012162	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
383372012163	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372012164	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
383372012165	AAK_FomA-like: This CD includes a fosfomycin biosynthetic gene product, FomA, and similar proteins found in a wide range of organisms. Together, the fomA and fomB genes in the fosfomycin biosynthetic gene cluster of Streptomyces wedmorensis confer...; Region: AAK_FomA-like; cd04241
383372012166	putative nucleotide binding site [chemical binding]; other site
383372012167	putative substrate binding site [chemical binding]; other site
383372012168	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
383372012169	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
383372012170	active site
383372012171	dimerization interface [polypeptide binding]; other site
383372012172	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
383372012173	Protein of unknown function (DUF524); Region: DUF524; pfam04411
383372012174	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
383372012175	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
383372012176	Part of AAA domain; Region: AAA_19; pfam13245
383372012177	Family description; Region: UvrD_C_2; pfam13538
383372012178	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
383372012179	Methyltransferase domain; Region: Methyltransf_11; pfam08241
383372012180	PAS domain S-box; Region: sensory_box; TIGR00229
383372012181	PAS domain; Region: PAS_8; pfam13188
383372012182	PAS domain; Region: PAS; smart00091
383372012183	PAS domain; Region: PAS_9; pfam13426
383372012184	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372012185	translocation protein TolB; Provisional; Region: tolB; PRK00178
383372012186	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
383372012187	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
383372012188	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
383372012189	protein binding site [polypeptide binding]; other site
383372012190	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
383372012191	Catalytic dyad [active]
383372012192	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
383372012193	active site
383372012194	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
383372012195	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
383372012196	Mg++ binding site [ion binding]; other site
383372012197	putative catalytic motif [active]
383372012198	substrate binding site [chemical binding]; other site
383372012199	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
383372012200	substrate binding site [chemical binding]; other site
383372012201	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
383372012202	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
383372012203	putative RNA binding site [nucleotide binding]; other site
383372012204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372012205	S-adenosylmethionine binding site [chemical binding]; other site
383372012206	Immunoglobulin domain; Region: Ig; cl11960
383372012207	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
383372012208	Fe-S cluster binding site [ion binding]; other site
383372012209	active site
383372012210	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
383372012211	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
383372012212	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
383372012213	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
383372012214	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
383372012215	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
383372012216	PGAP1-like protein; Region: PGAP1; pfam07819
383372012217	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
383372012218	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
383372012219	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
383372012220	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
383372012221	active site
383372012222	Substrate binding site; other site
383372012223	Mg++ binding site; other site
383372012224	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
383372012225	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372012226	Walker A motif; other site
383372012227	ATP binding site [chemical binding]; other site
383372012228	Walker B motif; other site
383372012229	arginine finger; other site
383372012230	Protein of unknown function (DUF503); Region: DUF503; pfam04456
383372012231	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
383372012232	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
383372012233	heterotetramer interface [polypeptide binding]; other site
383372012234	active site pocket [active]
383372012235	cleavage site
383372012236	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
383372012237	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
383372012238	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
383372012239	putative RNA binding site [nucleotide binding]; other site
383372012240	Methyltransferase domain; Region: Methyltransf_26; pfam13659
383372012241	Protein of unknown function (DUF1498); Region: DUF1498; cl17840
383372012242	Uncharacterized conserved protein [Function unknown]; Region: COG1262
383372012243	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
383372012244	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
383372012245	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372012246	Walker A/P-loop; other site
383372012247	ATP binding site [chemical binding]; other site
383372012248	Q-loop/lid; other site
383372012249	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372012250	ABC transporter signature motif; other site
383372012251	Walker B; other site
383372012252	D-loop; other site
383372012253	H-loop/switch region; other site
383372012254	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
383372012255	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
383372012256	dimer interface [polypeptide binding]; other site
383372012257	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
383372012258	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
383372012259	dimer interface [polypeptide binding]; other site
383372012260	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372012261	Major Facilitator Superfamily; Region: MFS_1; pfam07690
383372012262	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372012263	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
383372012264	anti sigma factor interaction site; other site
383372012265	regulatory phosphorylation site [posttranslational modification]; other site
383372012266	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
383372012267	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
383372012268	ATP binding site [chemical binding]; other site
383372012269	Mg2+ binding site [ion binding]; other site
383372012270	G-X-G motif; other site
383372012271	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
383372012272	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372012273	ATP binding site [chemical binding]; other site
383372012274	Mg2+ binding site [ion binding]; other site
383372012275	G-X-G motif; other site
383372012276	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
383372012277	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
383372012278	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
383372012279	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
383372012280	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
383372012281	catalytic residues [active]
383372012282	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
383372012283	putative homodimer interface [polypeptide binding]; other site
383372012284	putative homotetramer interface [polypeptide binding]; other site
383372012285	putative allosteric switch controlling residues; other site
383372012286	putative metal binding site [ion binding]; other site
383372012287	putative homodimer-homodimer interface [polypeptide binding]; other site
383372012288	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
383372012289	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372012290	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
383372012291	DNA binding residues [nucleotide binding]
383372012292	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
383372012293	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
383372012294	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
383372012295	hydroxyglutarate oxidase; Provisional; Region: PRK11728
383372012296	glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377
383372012297	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
383372012298	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
383372012299	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
383372012300	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
383372012301	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
383372012302	Cysteine-rich domain; Region: CCG; pfam02754
383372012303	Cysteine-rich domain; Region: CCG; pfam02754
383372012304	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
383372012305	active pocket/dimerization site; other site
383372012306	active site
383372012307	phosphorylation site [posttranslational modification]
383372012308	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
383372012309	dimerization domain swap beta strand [polypeptide binding]; other site
383372012310	regulatory protein interface [polypeptide binding]; other site
383372012311	active site
383372012312	regulatory phosphorylation site [posttranslational modification]; other site
383372012313	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
383372012314	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
383372012315	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
383372012316	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
383372012317	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
383372012318	Catalytic domain of Protein Kinases; Region: PKc; cd00180
383372012319	active site
383372012320	ATP binding site [chemical binding]; other site
383372012321	substrate binding site [chemical binding]; other site
383372012322	activation loop (A-loop); other site
383372012323	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
383372012324	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
383372012325	active site
383372012326	NTP binding site [chemical binding]; other site
383372012327	metal binding triad [ion binding]; metal-binding site
383372012328	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
383372012329	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
383372012330	Zn2+ binding site [ion binding]; other site
383372012331	Mg2+ binding site [ion binding]; other site
383372012332	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
383372012333	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
383372012334	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
383372012335	putative dimer interface [polypeptide binding]; other site
383372012336	Peptidase family M48; Region: Peptidase_M48; cl12018
383372012337	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
383372012338	thiamine phosphate binding site [chemical binding]; other site
383372012339	active site
383372012340	pyrophosphate binding site [ion binding]; other site
383372012341	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
383372012342	substrate binding site [chemical binding]; other site
383372012343	multimerization interface [polypeptide binding]; other site
383372012344	ATP binding site [chemical binding]; other site
383372012345	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
383372012346	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
383372012347	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
383372012348	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
383372012349	Walker A/P-loop; other site
383372012350	ATP binding site [chemical binding]; other site
383372012351	Q-loop/lid; other site
383372012352	ABC transporter signature motif; other site
383372012353	Walker B; other site
383372012354	D-loop; other site
383372012355	H-loop/switch region; other site
383372012356	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
383372012357	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
383372012358	Walker A/P-loop; other site
383372012359	ATP binding site [chemical binding]; other site
383372012360	Q-loop/lid; other site
383372012361	ABC transporter signature motif; other site
383372012362	Walker B; other site
383372012363	D-loop; other site
383372012364	H-loop/switch region; other site
383372012365	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
383372012366	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
383372012367	dimer interface [polypeptide binding]; other site
383372012368	substrate binding site [chemical binding]; other site
383372012369	ATP binding site [chemical binding]; other site
383372012370	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
383372012371	active site
383372012372	NTP binding site [chemical binding]; other site
383372012373	metal binding triad [ion binding]; metal-binding site
383372012374	antibiotic binding site [chemical binding]; other site
383372012375	HEPN domain; Region: HEPN; pfam05168
383372012376	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
383372012377	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
383372012378	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
383372012379	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
383372012380	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
383372012381	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
383372012382	PAS fold; Region: PAS; pfam00989
383372012383	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372012384	putative active site [active]
383372012385	heme pocket [chemical binding]; other site
383372012386	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372012387	GAF domain; Region: GAF; pfam01590
383372012388	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
383372012389	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
383372012390	Zn2+ binding site [ion binding]; other site
383372012391	Mg2+ binding site [ion binding]; other site
383372012392	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
383372012393	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
383372012394	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
383372012395	Probable Catalytic site; other site
383372012396	metal-binding site
383372012397	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372012398	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
383372012399	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
383372012400	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
383372012401	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
383372012402	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131
383372012403	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
383372012404	methionine sulfoxide reductase A; Provisional; Region: PRK14054
383372012405	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
383372012406	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
383372012407	FAD binding domain; Region: FAD_binding_4; pfam01565
383372012408	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
383372012409	putative active site [active]
383372012410	FAD binding domain; Region: FAD_binding_4; pfam01565
383372012411	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
383372012412	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
383372012413	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
383372012414	circadian clock protein KaiC; Reviewed; Region: PRK09302
383372012415	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
383372012416	Walker A motif; other site
383372012417	ATP binding site [chemical binding]; other site
383372012418	Walker B motif; other site
383372012419	recA bacterial DNA recombination protein; Region: RecA; cl17211
383372012420	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
383372012421	Walker A motif; other site
383372012422	ATP binding site [chemical binding]; other site
383372012423	Walker B motif; other site
383372012424	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
383372012425	tetramer interface [polypeptide binding]; other site
383372012426	dimer interface [polypeptide binding]; other site
383372012427	Response regulator receiver domain; Region: Response_reg; pfam00072
383372012428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372012429	active site
383372012430	phosphorylation site [posttranslational modification]
383372012431	intermolecular recognition site; other site
383372012432	dimerization interface [polypeptide binding]; other site
383372012433	PAS fold; Region: PAS_4; pfam08448
383372012434	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372012435	dimer interface [polypeptide binding]; other site
383372012436	phosphorylation site [posttranslational modification]
383372012437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372012438	ATP binding site [chemical binding]; other site
383372012439	Mg2+ binding site [ion binding]; other site
383372012440	G-X-G motif; other site
383372012441	Response regulator receiver domain; Region: Response_reg; pfam00072
383372012442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372012443	active site
383372012444	phosphorylation site [posttranslational modification]
383372012445	intermolecular recognition site; other site
383372012446	dimerization interface [polypeptide binding]; other site
383372012447	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
383372012448	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
383372012449	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372012450	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372012451	active site
383372012452	phosphorylation site [posttranslational modification]
383372012453	intermolecular recognition site; other site
383372012454	dimerization interface [polypeptide binding]; other site
383372012455	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
383372012456	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
383372012457	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
383372012458	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
383372012459	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
383372012460	ATP binding site [chemical binding]; other site
383372012461	Walker A motif; other site
383372012462	hexamer interface [polypeptide binding]; other site
383372012463	Walker B motif; other site
383372012464	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
383372012465	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
383372012466	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
383372012467	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
383372012468	metal ion-dependent adhesion site (MIDAS); other site
383372012469	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
383372012470	TadE-like protein; Region: TadE; pfam07811
383372012471	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
383372012472	PCRF domain; Region: PCRF; pfam03462
383372012473	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
383372012474	RF-1 domain; Region: RF-1; pfam00472
383372012475	NAD-dependent deacetylase; Provisional; Region: PRK00481
383372012476	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
383372012477	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cd08368
383372012478	Zn binding site [ion binding]; other site
383372012479	Protein of unknown function (DUF3633); Region: DUF3633; pfam12315
383372012480	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
383372012481	Zn binding site [ion binding]; other site
383372012482	HD domain; Region: HD_3; pfam13023
383372012483	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
383372012484	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
383372012485	Ca binding site [ion binding]; other site
383372012486	active site
383372012487	catalytic site [active]
383372012488	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
383372012489	heat shock protein 90; Provisional; Region: PRK05218
383372012490	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372012491	ATP binding site [chemical binding]; other site
383372012492	Mg2+ binding site [ion binding]; other site
383372012493	G-X-G motif; other site
383372012494	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
383372012495	HlyD family secretion protein; Region: HlyD_3; pfam13437
383372012496	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
383372012497	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
383372012498	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
383372012499	Putative glycosyl hydrolase domain; Region: DUF4015; cl17870
383372012500	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
383372012501	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
383372012502	active site
383372012503	Radical SAM superfamily; Region: Radical_SAM; pfam04055
383372012504	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372012505	FeS/SAM binding site; other site
383372012506	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
383372012507	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372012508	S-adenosylmethionine binding site [chemical binding]; other site
383372012509	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
383372012510	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
383372012511	Moco binding site; other site
383372012512	metal coordination site [ion binding]; other site
383372012513	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
383372012514	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
383372012515	CoA-binding site [chemical binding]; other site
383372012516	ATP-binding [chemical binding]; other site
383372012517	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
383372012518	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
383372012519	active site
383372012520	putative substrate binding pocket [chemical binding]; other site
383372012521	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
383372012522	DNA methylase; Region: N6_N4_Mtase; pfam01555
383372012523	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372012524	S-adenosylmethionine binding site [chemical binding]; other site
383372012525	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
383372012526	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
383372012527	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
383372012528	Domain of unknown function (DUF955); Region: DUF955; pfam06114
383372012529	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
383372012530	Family description; Region: UvrD_C_2; pfam13538
383372012531	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
383372012532	non-specific DNA binding site [nucleotide binding]; other site
383372012533	salt bridge; other site
383372012534	sequence-specific DNA binding site [nucleotide binding]; other site
383372012535	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
383372012536	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372012537	DNA binding residues [nucleotide binding]
383372012538	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
383372012539	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
383372012540	conserved hypothetical integral membrane protein; Region: TIGR03766
383372012541	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
383372012542	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
383372012543	Peptidase family M23; Region: Peptidase_M23; pfam01551
383372012544	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
383372012545	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372012546	ATP binding site [chemical binding]; other site
383372012547	Mg2+ binding site [ion binding]; other site
383372012548	G-X-G motif; other site
383372012549	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
383372012550	anchoring element; other site
383372012551	dimer interface [polypeptide binding]; other site
383372012552	ATP binding site [chemical binding]; other site
383372012553	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
383372012554	active site
383372012555	putative metal-binding site [ion binding]; other site
383372012556	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
383372012557	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
383372012558	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
383372012559	adenylosuccinate lyase; Provisional; Region: PRK09285
383372012560	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
383372012561	tetramer interface [polypeptide binding]; other site
383372012562	active site
383372012563	Protein of unknown function (DUF454); Region: DUF454; pfam04304
383372012564	CheW-like domain; Region: CheW; pfam01584
383372012565	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
383372012566	dimer interface [polypeptide binding]; other site
383372012567	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
383372012568	putative CheW interface [polypeptide binding]; other site
383372012569	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
383372012570	putative binding surface; other site
383372012571	active site
383372012572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372012573	ATP binding site [chemical binding]; other site
383372012574	Mg2+ binding site [ion binding]; other site
383372012575	G-X-G motif; other site
383372012576	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
383372012577	Response regulator receiver domain; Region: Response_reg; pfam00072
383372012578	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372012579	active site
383372012580	phosphorylation site [posttranslational modification]
383372012581	intermolecular recognition site; other site
383372012582	dimerization interface [polypeptide binding]; other site
383372012583	Response regulator receiver domain; Region: Response_reg; pfam00072
383372012584	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372012585	active site
383372012586	phosphorylation site [posttranslational modification]
383372012587	intermolecular recognition site; other site
383372012588	dimerization interface [polypeptide binding]; other site
383372012589	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
383372012590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372012591	active site
383372012592	phosphorylation site [posttranslational modification]
383372012593	intermolecular recognition site; other site
383372012594	dimerization interface [polypeptide binding]; other site
383372012595	CheB methylesterase; Region: CheB_methylest; pfam01339
383372012596	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
383372012597	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372012598	S-adenosylmethionine binding site [chemical binding]; other site
383372012599	TPR repeat; Region: TPR_11; pfam13414
383372012600	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372012601	binding surface
383372012602	TPR motif; other site
383372012603	Tetratricopeptide repeat; Region: TPR_16; pfam13432
383372012604	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
383372012605	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
383372012606	TPR repeat; Region: TPR_11; pfam13414
383372012607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372012608	binding surface
383372012609	TPR motif; other site
383372012610	TPR repeat; Region: TPR_11; pfam13414
383372012611	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372012612	binding surface
383372012613	TPR motif; other site
383372012614	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372012615	binding surface
383372012616	TPR motif; other site
383372012617	TPR repeat; Region: TPR_11; pfam13414
383372012618	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372012619	binding surface
383372012620	TPR motif; other site
383372012621	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372012622	binding surface
383372012623	TPR motif; other site
383372012624	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
383372012625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372012626	ATP binding site [chemical binding]; other site
383372012627	Mg2+ binding site [ion binding]; other site
383372012628	G-X-G motif; other site
383372012629	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
383372012630	anti sigma factor interaction site; other site
383372012631	regulatory phosphorylation site [posttranslational modification]; other site
383372012632	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
383372012633	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
383372012634	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
383372012635	chorismate binding enzyme; Region: Chorismate_bind; cl10555
383372012636	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
383372012637	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
383372012638	dimer interface [polypeptide binding]; other site
383372012639	tetramer interface [polypeptide binding]; other site
383372012640	PYR/PP interface [polypeptide binding]; other site
383372012641	TPP binding site [chemical binding]; other site
383372012642	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
383372012643	TPP-binding site; other site
383372012644	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
383372012645	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
383372012646	substrate binding site [chemical binding]; other site
383372012647	oxyanion hole (OAH) forming residues; other site
383372012648	trimer interface [polypeptide binding]; other site
383372012649	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
383372012650	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
383372012651	acyl-activating enzyme (AAE) consensus motif; other site
383372012652	putative AMP binding site [chemical binding]; other site
383372012653	putative active site [active]
383372012654	putative CoA binding site [chemical binding]; other site
383372012655	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
383372012656	Phosphotransferase enzyme family; Region: APH; pfam01636
383372012657	putative active site [active]
383372012658	putative substrate binding site [chemical binding]; other site
383372012659	ATP binding site [chemical binding]; other site
383372012660	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372012661	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372012662	DNA binding residues [nucleotide binding]
383372012663	dimerization interface [polypeptide binding]; other site
383372012664	Transposase IS200 like; Region: Y1_Tnp; cl00848
383372012665	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
383372012666	Coenzyme A binding pocket [chemical binding]; other site
383372012667	CAAX protease self-immunity; Region: Abi; pfam02517
383372012668	Cache domain; Region: Cache_1; pfam02743
383372012669	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
383372012670	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372012671	dimerization interface [polypeptide binding]; other site
383372012672	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
383372012673	Histidine kinase; Region: HisKA_3; pfam07730
383372012674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372012675	ATP binding site [chemical binding]; other site
383372012676	Mg2+ binding site [ion binding]; other site
383372012677	G-X-G motif; other site
383372012678	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372012679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372012680	active site
383372012681	phosphorylation site [posttranslational modification]
383372012682	intermolecular recognition site; other site
383372012683	dimerization interface [polypeptide binding]; other site
383372012684	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372012685	DNA binding residues [nucleotide binding]
383372012686	dimerization interface [polypeptide binding]; other site
383372012687	Response regulator receiver domain; Region: Response_reg; pfam00072
383372012688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372012689	active site
383372012690	phosphorylation site [posttranslational modification]
383372012691	intermolecular recognition site; other site
383372012692	dimerization interface [polypeptide binding]; other site
383372012693	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
383372012694	LabA_like proteins; Region: LabA_like; cd06167
383372012695	putative metal binding site [ion binding]; other site
383372012696	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
383372012697	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
383372012698	putative active site pocket [active]
383372012699	dimerization interface [polypeptide binding]; other site
383372012700	putative catalytic residue [active]
383372012701	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
383372012702	Predicted ATPase [General function prediction only]; Region: COG4637
383372012703	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372012704	Walker A/P-loop; other site
383372012705	ATP binding site [chemical binding]; other site
383372012706	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372012707	ABC transporter signature motif; other site
383372012708	Walker B; other site
383372012709	D-loop; other site
383372012710	H-loop/switch region; other site
383372012711	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
383372012712	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701
383372012713	CRISPR-associated protein, Csx11 family; Region: cas_csx11; TIGR02682
383372012714	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
383372012715	AAA domain; Region: AAA_21; pfam13304
383372012716	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
383372012717	trehalose synthase; Region: treS_nterm; TIGR02456
383372012718	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
383372012719	Ca binding site [ion binding]; other site
383372012720	active site
383372012721	catalytic site [active]
383372012722	DNA photolyase; Region: DNA_photolyase; pfam00875
383372012723	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
383372012724	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
383372012725	putative acyl-acceptor binding pocket; other site
383372012726	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
383372012727	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
383372012728	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
383372012729	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
383372012730	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
383372012731	catalytic core [active]
383372012732	conserved hypothetical protein; Region: TIGR03847
383372012733	conserved hypothetical protein; Region: TIGR03843
383372012734	ferredoxin-NADP+ reductase; Region: PLN02852
383372012735	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
383372012736	FeoC like transcriptional regulator; Region: FeoC; pfam09012
383372012737	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
383372012738	Nucleoside recognition; Region: Gate; pfam07670
383372012739	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
383372012740	Nucleoside recognition; Region: Gate; pfam07670
383372012741	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
383372012742	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
383372012743	G1 box; other site
383372012744	GTP/Mg2+ binding site [chemical binding]; other site
383372012745	Switch I region; other site
383372012746	G2 box; other site
383372012747	G3 box; other site
383372012748	Switch II region; other site
383372012749	G4 box; other site
383372012750	FeoA domain; Region: FeoA; pfam04023
383372012751	FeoA domain; Region: FeoA; pfam04023
383372012752	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
383372012753	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
383372012754	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
383372012755	catalytic residue [active]
383372012756	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
383372012757	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
383372012758	Walker A/P-loop; other site
383372012759	ATP binding site [chemical binding]; other site
383372012760	Q-loop/lid; other site
383372012761	ABC transporter signature motif; other site
383372012762	Walker B; other site
383372012763	D-loop; other site
383372012764	H-loop/switch region; other site
383372012765	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
383372012766	GTPase CgtA; Reviewed; Region: obgE; PRK12297
383372012767	GTP1/OBG; Region: GTP1_OBG; pfam01018
383372012768	Obg GTPase; Region: Obg; cd01898
383372012769	G1 box; other site
383372012770	GTP/Mg2+ binding site [chemical binding]; other site
383372012771	Switch I region; other site
383372012772	G2 box; other site
383372012773	G3 box; other site
383372012774	Switch II region; other site
383372012775	G4 box; other site
383372012776	G5 box; other site
383372012777	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
383372012778	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
383372012779	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372012780	Bacterial sugar transferase; Region: Bac_transf; pfam02397
383372012781	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
383372012782	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
383372012783	NAD binding site [chemical binding]; other site
383372012784	putative substrate binding site 2 [chemical binding]; other site
383372012785	putative substrate binding site 1 [chemical binding]; other site
383372012786	active site
383372012787	O-Antigen ligase; Region: Wzy_C; pfam04932
383372012788	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
383372012789	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
383372012790	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
383372012791	NAD(P) binding site [chemical binding]; other site
383372012792	active site
383372012793	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
383372012794	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
383372012795	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372012796	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
383372012797	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
383372012798	N- and C-terminal domain interface [polypeptide binding]; other site
383372012799	active site
383372012800	catalytic site [active]
383372012801	metal binding site [ion binding]; metal-binding site
383372012802	carbohydrate binding site [chemical binding]; other site
383372012803	ATP binding site [chemical binding]; other site
383372012804	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372012805	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
383372012806	DNA polymerase III subunit delta'; Validated; Region: PRK08485
383372012807	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
383372012808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372012809	active site
383372012810	phosphorylation site [posttranslational modification]
383372012811	intermolecular recognition site; other site
383372012812	dimerization interface [polypeptide binding]; other site
383372012813	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
383372012814	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
383372012815	dimer interface [polypeptide binding]; other site
383372012816	active site
383372012817	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
383372012818	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
383372012819	PLD-like domain; Region: PLDc_2; pfam13091
383372012820	putative active site [active]
383372012821	catalytic site [active]
383372012822	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
383372012823	PLD-like domain; Region: PLDc_2; pfam13091
383372012824	putative active site [active]
383372012825	catalytic site [active]
383372012826	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372012827	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
383372012828	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
383372012829	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
383372012830	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
383372012831	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
383372012832	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
383372012833	Zn2+ binding site [ion binding]; other site
383372012834	Mg2+ binding site [ion binding]; other site
383372012835	Yqey-like protein; Region: YqeY; pfam09424
383372012836	Guanylate kinase; Region: Guanylate_kin; pfam00625
383372012837	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
383372012838	catalytic site [active]
383372012839	G-X2-G-X-G-K; other site
383372012840	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
383372012841	Domain of unknown function (DUF814); Region: DUF814; pfam05670
383372012842	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
383372012843	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
383372012844	ATP-grasp domain; Region: ATP-grasp_4; cl17255
383372012845	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
383372012846	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
383372012847	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
383372012848	carboxyltransferase (CT) interaction site; other site
383372012849	biotinylation site [posttranslational modification]; other site
383372012850	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
383372012851	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
383372012852	inhibitor site; inhibition site
383372012853	active site
383372012854	dimer interface [polypeptide binding]; other site
383372012855	catalytic residue [active]
383372012856	Methyltransferase domain; Region: Methyltransf_26; pfam13659
383372012857	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
383372012858	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372012859	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
383372012860	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
383372012861	motif II; other site
383372012862	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
383372012863	Cysteine-rich domain; Region: CCG; pfam02754
383372012864	Cysteine-rich domain; Region: CCG; pfam02754
383372012865	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
383372012866	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
383372012867	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
383372012868	TrkA-N domain; Region: TrkA_N; pfam02254
383372012869	TrkA-C domain; Region: TrkA_C; pfam02080
383372012870	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372012871	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372012872	active site
383372012873	phosphorylation site [posttranslational modification]
383372012874	intermolecular recognition site; other site
383372012875	dimerization interface [polypeptide binding]; other site
383372012876	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372012877	DNA binding site [nucleotide binding]
383372012878	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
383372012879	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
383372012880	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
383372012881	PBP superfamily domain; Region: PBP_like_2; cl17296
383372012882	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
383372012883	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372012884	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
383372012885	dimerization interface [polypeptide binding]; other site
383372012886	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372012887	dimer interface [polypeptide binding]; other site
383372012888	phosphorylation site [posttranslational modification]
383372012889	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372012890	ATP binding site [chemical binding]; other site
383372012891	Mg2+ binding site [ion binding]; other site
383372012892	G-X-G motif; other site
383372012893	Response regulator receiver domain; Region: Response_reg; pfam00072
383372012894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372012895	active site
383372012896	phosphorylation site [posttranslational modification]
383372012897	intermolecular recognition site; other site
383372012898	dimerization interface [polypeptide binding]; other site
383372012899	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
383372012900	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
383372012901	active site
383372012902	substrate binding site [chemical binding]; other site
383372012903	metal binding site [ion binding]; metal-binding site
383372012904	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
383372012905	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
383372012906	UbiA prenyltransferase family; Region: UbiA; pfam01040
383372012907	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
383372012908	Sulfatase; Region: Sulfatase; cl17466
383372012909	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
383372012910	Uncharacterized conserved protein [Function unknown]; Region: COG3379
383372012911	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
383372012912	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537
383372012913	ATP-sulfurylase; Region: ATPS; cd00517
383372012914	active site
383372012915	HXXH motif; other site
383372012916	flexible loop; other site
383372012917	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
383372012918	ligand-binding site [chemical binding]; other site
383372012919	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
383372012920	active site
383372012921	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
383372012922	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
383372012923	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
383372012924	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
383372012925	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
383372012926	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
383372012927	active site
383372012928	HIGH motif; other site
383372012929	nucleotide binding site [chemical binding]; other site
383372012930	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
383372012931	KMSKS motif; other site
383372012932	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
383372012933	tRNA binding surface [nucleotide binding]; other site
383372012934	anticodon binding site; other site
383372012935	This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840
383372012936	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
383372012937	L11 interface [polypeptide binding]; other site
383372012938	putative EF-Tu interaction site [polypeptide binding]; other site
383372012939	putative EF-G interaction site [polypeptide binding]; other site
383372012940	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
383372012941	23S rRNA interface [nucleotide binding]; other site
383372012942	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
383372012943	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
383372012944	mRNA/rRNA interface [nucleotide binding]; other site
383372012945	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
383372012946	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
383372012947	23S rRNA interface [nucleotide binding]; other site
383372012948	L7/L12 interface [polypeptide binding]; other site
383372012949	putative thiostrepton binding site; other site
383372012950	L25 interface [polypeptide binding]; other site
383372012951	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
383372012952	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
383372012953	putative homodimer interface [polypeptide binding]; other site
383372012954	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
383372012955	heterodimer interface [polypeptide binding]; other site
383372012956	homodimer interface [polypeptide binding]; other site
383372012957	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
383372012958	elongation factor Tu; Reviewed; Region: PRK00049
383372012959	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
383372012960	G1 box; other site
383372012961	GEF interaction site [polypeptide binding]; other site
383372012962	GTP/Mg2+ binding site [chemical binding]; other site
383372012963	Switch I region; other site
383372012964	G2 box; other site
383372012965	G3 box; other site
383372012966	Switch II region; other site
383372012967	G4 box; other site
383372012968	G5 box; other site
383372012969	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
383372012970	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
383372012971	Antibiotic Binding Site [chemical binding]; other site
383372012972	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
383372012973	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
383372012974	dimerization interface [polypeptide binding]; other site
383372012975	ligand binding site [chemical binding]; other site
383372012976	NADP binding site [chemical binding]; other site
383372012977	catalytic site [active]
383372012978	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
383372012979	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
383372012980	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372012981	DNA binding residues [nucleotide binding]
383372012982	H+ Antiporter protein; Region: 2A0121; TIGR00900
383372012983	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
383372012984	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
383372012985	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
383372012986	hinge; other site
383372012987	active site
383372012988	YGGT family; Region: YGGT; pfam02325
383372012989	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
383372012990	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372012991	dimer interface [polypeptide binding]; other site
383372012992	phosphorylation site [posttranslational modification]
383372012993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372012994	ATP binding site [chemical binding]; other site
383372012995	Mg2+ binding site [ion binding]; other site
383372012996	G-X-G motif; other site
383372012997	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
383372012998	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
383372012999	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
383372013000	metal binding site [ion binding]; metal-binding site
383372013001	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
383372013002	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
383372013003	purine monophosphate binding site [chemical binding]; other site
383372013004	dimer interface [polypeptide binding]; other site
383372013005	putative catalytic residues [active]
383372013006	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
383372013007	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
383372013008	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
383372013009	MarR family; Region: MarR_2; pfam12802
383372013010	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
383372013011	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
383372013012	G1 box; other site
383372013013	GTP/Mg2+ binding site [chemical binding]; other site
383372013014	G2 box; other site
383372013015	Switch I region; other site
383372013016	G3 box; other site
383372013017	Switch II region; other site
383372013018	G4 box; other site
383372013019	G5 box; other site
383372013020	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
383372013021	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
383372013022	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
383372013023	putative dimer interface [polypeptide binding]; other site
383372013024	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372013025	GAF domain; Region: GAF_3; pfam13492
383372013026	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
383372013027	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
383372013028	putative active site [active]
383372013029	heme pocket [chemical binding]; other site
383372013030	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
383372013031	dimer interface [polypeptide binding]; other site
383372013032	phosphorylation site [posttranslational modification]
383372013033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372013034	ATP binding site [chemical binding]; other site
383372013035	Mg2+ binding site [ion binding]; other site
383372013036	G-X-G motif; other site
383372013037	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372013038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372013039	active site
383372013040	phosphorylation site [posttranslational modification]
383372013041	intermolecular recognition site; other site
383372013042	dimerization interface [polypeptide binding]; other site
383372013043	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372013044	DNA binding site [nucleotide binding]
383372013045	ScpA/B protein; Region: ScpA_ScpB; cl00598
383372013046	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
383372013047	aromatic arch; other site
383372013048	DCoH dimer interaction site [polypeptide binding]; other site
383372013049	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
383372013050	DCoH tetramer interaction site [polypeptide binding]; other site
383372013051	substrate binding site [chemical binding]; other site
383372013052	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
383372013053	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
383372013054	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
383372013055	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
383372013056	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
383372013057	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
383372013058	DNA binding residues [nucleotide binding]
383372013059	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
383372013060	active site
383372013061	dimer interface [polypeptide binding]; other site
383372013062	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
383372013063	SmpB-tmRNA interface; other site
383372013064	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372013065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372013066	active site
383372013067	phosphorylation site [posttranslational modification]
383372013068	intermolecular recognition site; other site
383372013069	dimerization interface [polypeptide binding]; other site
383372013070	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372013071	DNA binding site [nucleotide binding]
383372013072	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
383372013073	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
383372013074	Walker A motif; other site
383372013075	ATP binding site [chemical binding]; other site
383372013076	Walker B motif; other site
383372013077	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
383372013078	GxxExxY protein; Region: GxxExxY; TIGR04256
383372013079	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
383372013080	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
383372013081	Walker A/P-loop; other site
383372013082	ATP binding site [chemical binding]; other site
383372013083	Q-loop/lid; other site
383372013084	ABC transporter signature motif; other site
383372013085	Walker B; other site
383372013086	D-loop; other site
383372013087	H-loop/switch region; other site
383372013088	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
383372013089	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
383372013090	Walker A/P-loop; other site
383372013091	ATP binding site [chemical binding]; other site
383372013092	Q-loop/lid; other site
383372013093	ABC transporter signature motif; other site
383372013094	Walker B; other site
383372013095	D-loop; other site
383372013096	H-loop/switch region; other site
383372013097	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
383372013098	FtsX-like permease family; Region: FtsX; pfam02687
383372013099	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
383372013100	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
383372013101	HlyD family secretion protein; Region: HlyD_3; pfam13437
383372013102	H+ Antiporter protein; Region: 2A0121; TIGR00900
383372013103	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372013104	putative substrate translocation pore; other site
383372013105	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
383372013106	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
383372013107	tetramer interface [polypeptide binding]; other site
383372013108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
383372013109	catalytic residue [active]
383372013110	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
383372013111	cobalt transport protein CbiM; Validated; Region: PRK06265
383372013112	PDGLE domain; Region: PDGLE; pfam13190
383372013113	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
383372013114	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
383372013115	Cytochrome P450; Region: p450; cl12078
383372013116	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
383372013117	FeoA domain; Region: FeoA; pfam04023
383372013118	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
383372013119	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
383372013120	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
383372013121	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
383372013122	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
383372013123	putative PBP binding regions; other site
383372013124	ABC-ATPase subunit  interface; other site
383372013125	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
383372013126	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
383372013127	putative hemin binding site; other site
383372013128	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
383372013129	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
383372013130	Walker A/P-loop; other site
383372013131	ATP binding site [chemical binding]; other site
383372013132	Q-loop/lid; other site
383372013133	ABC transporter signature motif; other site
383372013134	Walker B; other site
383372013135	D-loop; other site
383372013136	H-loop/switch region; other site
383372013137	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
383372013138	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
383372013139	isocitrate lyase; Provisional; Region: PRK15063
383372013140	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
383372013141	tetramer interface [polypeptide binding]; other site
383372013142	active site
383372013143	Mg2+/Mn2+ binding site [ion binding]; other site
383372013144	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
383372013145	malate synthase A; Region: malate_syn_A; TIGR01344
383372013146	active site
383372013147	PIN domain; Region: PIN_3; cl17397
383372013148	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
383372013149	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
383372013150	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
383372013151	molybdopterin cofactor binding site; other site
383372013152	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
383372013153	molybdopterin cofactor binding site; other site
383372013154	Protein of unknown function DUF45; Region: DUF45; cl00636
383372013155	Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277
383372013156	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
383372013157	FeS/SAM binding site; other site
383372013158	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
383372013159	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
383372013160	GrpE; Region: GrpE; pfam01025
383372013161	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
383372013162	dimer interface [polypeptide binding]; other site
383372013163	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
383372013164	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
383372013165	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
383372013166	nucleotide binding site [chemical binding]; other site
383372013167	NEF interaction site [polypeptide binding]; other site
383372013168	SBD interface [polypeptide binding]; other site
383372013169	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
383372013170	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
383372013171	HSP70 interaction site [polypeptide binding]; other site
383372013172	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
383372013173	substrate binding site [polypeptide binding]; other site
383372013174	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
383372013175	Zn binding sites [ion binding]; other site
383372013176	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
383372013177	dimer interface [polypeptide binding]; other site
383372013178	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
383372013179	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
383372013180	metal binding triad [ion binding]; metal-binding site
383372013181	integron integrase; Region: integrase_gron; TIGR02249
383372013182	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
383372013183	active site
383372013184	Int/Topo IB signature motif; other site
383372013185	DNA binding site [nucleotide binding]
383372013186	DNA methylase; Region: N6_N4_Mtase; cl17433
383372013187	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364
383372013188	L11 interface [polypeptide binding]; other site
383372013189	putative EF-Tu interaction site [polypeptide binding]; other site
383372013190	putative EF-G interaction site [polypeptide binding]; other site
383372013191	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
383372013192	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
383372013193	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
383372013194	putative substrate binding site [chemical binding]; other site
383372013195	putative ATP binding site [chemical binding]; other site
383372013196	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
383372013197	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
383372013198	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
383372013199	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
383372013200	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
383372013201	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
383372013202	Walker A/P-loop; other site
383372013203	ATP binding site [chemical binding]; other site
383372013204	Q-loop/lid; other site
383372013205	ABC transporter signature motif; other site
383372013206	Walker B; other site
383372013207	D-loop; other site
383372013208	H-loop/switch region; other site
383372013209	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
383372013210	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
383372013211	Walker A/P-loop; other site
383372013212	ATP binding site [chemical binding]; other site
383372013213	Q-loop/lid; other site
383372013214	ABC transporter signature motif; other site
383372013215	Walker B; other site
383372013216	D-loop; other site
383372013217	H-loop/switch region; other site
383372013218	TPR repeat; Region: TPR_11; pfam13414
383372013219	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
383372013220	binding surface
383372013221	TPR motif; other site
383372013222	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372013223	binding surface
383372013224	TPR motif; other site
383372013225	TPR repeat; Region: TPR_11; pfam13414
383372013226	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
383372013227	DNA photolyase; Region: DNA_photolyase; pfam00875
383372013228	Uncharacterized conserved protein [Function unknown]; Region: COG1432
383372013229	LabA_like proteins; Region: LabA_like; cd06167
383372013230	putative metal binding site [ion binding]; other site
383372013231	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
383372013232	active site
383372013233	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
383372013234	putative active site [active]
383372013235	putative metal binding site [ion binding]; other site
383372013236	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
383372013237	Trm112p-like protein; Region: Trm112p; cl01066
383372013238	Uncharacterized protein involved in cysteine biosynthesis [Amino acid transport and metabolism]; Region: CysZ; COG2981
383372013239	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
383372013240	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
383372013241	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
383372013242	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
383372013243	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
383372013244	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
383372013245	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
383372013246	Transposase domain (DUF772); Region: DUF772; pfam05598
383372013247	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
383372013248	Major Facilitator Superfamily; Region: MFS_1; pfam07690
383372013249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
383372013250	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
383372013251	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
383372013252	active site
383372013253	catalytic tetrad [active]
383372013254	Predicted membrane protein [Function unknown]; Region: COG2311
383372013255	Protein of unknown function (DUF418); Region: DUF418; cl12135
383372013256	Protein of unknown function (DUF418); Region: DUF418; pfam04235
383372013257	Bacterial transcriptional activator domain; Region: BTAD; smart01043
383372013258	AAA ATPase domain; Region: AAA_16; pfam13191
383372013259	Tetratricopeptide repeat; Region: TPR_12; pfam13424
383372013260	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372013261	binding surface
383372013262	TPR motif; other site
383372013263	Uncharacterized conserved protein [Function unknown]; Region: COG2353
383372013264	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
383372013265	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
383372013266	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
383372013267	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
383372013268	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
383372013269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372013270	active site
383372013271	phosphorylation site [posttranslational modification]
383372013272	intermolecular recognition site; other site
383372013273	dimerization interface [polypeptide binding]; other site
383372013274	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
383372013275	DNA binding residues [nucleotide binding]
383372013276	dimerization interface [polypeptide binding]; other site
383372013277	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
383372013278	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
383372013279	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
383372013280	dimer interface [polypeptide binding]; other site
383372013281	active site
383372013282	catalytic nucleophile [active]
383372013283	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
383372013284	S-adenosylmethionine binding site [chemical binding]; other site
383372013285	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
383372013286	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
383372013287	dimer interface [polypeptide binding]; other site
383372013288	active site
383372013289	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
383372013290	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
383372013291	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
383372013292	NAD binding site [chemical binding]; other site
383372013293	substrate binding site [chemical binding]; other site
383372013294	catalytic Zn binding site [ion binding]; other site
383372013295	tetramer interface [polypeptide binding]; other site
383372013296	structural Zn binding site [ion binding]; other site
383372013297	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
383372013298	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
383372013299	Walker A/P-loop; other site
383372013300	ATP binding site [chemical binding]; other site
383372013301	Q-loop/lid; other site
383372013302	ABC transporter signature motif; other site
383372013303	Walker B; other site
383372013304	D-loop; other site
383372013305	CcmB protein; Region: CcmB; cl17444
383372013306	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
383372013307	CcmE; Region: CcmE; cl00994
383372013308	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
383372013309	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
383372013310	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
383372013311	HSP70 interaction site [polypeptide binding]; other site
383372013312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
383372013313	TPR motif; other site
383372013314	binding surface
383372013315	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
383372013316	putative active site [active]
383372013317	homotetrameric interface [polypeptide binding]; other site
383372013318	metal binding site [ion binding]; metal-binding site
383372013319	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
383372013320	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
383372013321	catalytic residues [active]
383372013322	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
383372013323	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
383372013324	active site
383372013325	phosphorylation site [posttranslational modification]
383372013326	intermolecular recognition site; other site
383372013327	dimerization interface [polypeptide binding]; other site
383372013328	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
383372013329	DNA binding site [nucleotide binding]
383372013330	gamma-glutamyl kinase; Provisional; Region: PRK05429
383372013331	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
383372013332	nucleotide binding site [chemical binding]; other site
383372013333	homotetrameric interface [polypeptide binding]; other site
383372013334	putative phosphate binding site [ion binding]; other site
383372013335	putative allosteric binding site; other site
383372013336	PUA domain; Region: PUA; pfam01472
383372013337	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
383372013338	putative catalytic cysteine [active]
383372013339	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
383372013340	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
383372013341	phosphate binding site [ion binding]; other site
383372013342	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
383372013343	Cytochrome P450; Region: p450; cl12078
383372013344	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372013345	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
383372013346	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
383372013347	GAF domain; Region: GAF_3; pfam13492
383372013348	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
383372013349	Histidine kinase; Region: HisKA_2; pfam07568
383372013350	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
383372013351	Mg2+ binding site [ion binding]; other site
383372013352	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
383372013353	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
383372013354	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
383372013355	active site
383372013356	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079