-- dump date 20140620_041018 -- class Genbank::misc_feature -- table misc_feature_note -- id note 391595000001 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 391595000002 MerR family regulatory protein; Region: MerR; pfam00376 391595000003 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391595000004 P-loop; other site 391595000005 Magnesium ion binding site [ion binding]; other site 391595000006 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391595000007 Magnesium ion binding site [ion binding]; other site 391595000008 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 391595000009 ParB-like nuclease domain; Region: ParB; smart00470 391595000010 Replication protein C N-terminal domain; Region: RP-C; pfam03428 391595000011 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 391595000012 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 391595000013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595000014 Walker A motif; other site 391595000015 ATP binding site [chemical binding]; other site 391595000016 Walker B motif; other site 391595000017 arginine finger; other site 391595000018 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 391595000019 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 391595000020 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595000021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595000022 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595000023 dimerization interface [polypeptide binding]; other site 391595000024 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391595000025 SnoaL-like domain; Region: SnoaL_2; pfam12680 391595000026 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 391595000027 DNA binding residues [nucleotide binding] 391595000028 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 391595000029 dimer interface [polypeptide binding]; other site 391595000030 putative metal binding site [ion binding]; other site 391595000031 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 391595000032 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 391595000033 TrbC/VIRB2 family; Region: TrbC; pfam04956 391595000034 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391595000035 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391595000036 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391595000037 catalytic residue [active] 391595000038 PIN domain; Region: PIN_3; pfam13470 391595000039 Helix-turn-helix domain; Region: HTH_17; cl17695 391595000040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391595000041 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391595000042 Phospholipid methyltransferase; Region: PEMT; pfam04191 391595000043 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 391595000044 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 391595000045 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 391595000046 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 391595000047 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 391595000048 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 391595000049 DNA binding residues [nucleotide binding] 391595000050 dimer interface [polypeptide binding]; other site 391595000051 putative metal binding site [ion binding]; other site 391595000052 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 391595000053 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 391595000054 Cu(I) binding site [ion binding]; other site 391595000055 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 391595000056 Thioredoxin; Region: Thioredoxin_4; pfam13462 391595000057 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 391595000058 Protein of unknown function (DUF461); Region: DUF461; pfam04314 391595000059 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 391595000060 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 391595000061 Cu(I) binding site [ion binding]; other site 391595000062 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391595000063 Peptidase family M23; Region: Peptidase_M23; pfam01551 391595000064 Protein of unknown function, DUF; Region: DUF411; cl01142 391595000065 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 391595000066 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 391595000067 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 391595000068 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 391595000069 putative active site [active] 391595000070 catalytic triad [active] 391595000071 putative dimer interface [polypeptide binding]; other site 391595000072 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 391595000073 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391595000074 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391595000075 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391595000076 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 391595000077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391595000078 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391595000079 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 391595000080 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 391595000081 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 391595000082 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 391595000083 HlyD family secretion protein; Region: HlyD_3; pfam13437 391595000084 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 391595000085 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 391595000086 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 391595000087 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 391595000088 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 391595000089 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391595000090 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391595000091 active site residue [active] 391595000092 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 391595000093 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 391595000094 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 391595000095 DsbD alpha interface [polypeptide binding]; other site 391595000096 catalytic residues [active] 391595000097 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 391595000098 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 391595000099 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391595000100 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391595000101 Soluble P-type ATPase [General function prediction only]; Region: COG4087 391595000102 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 391595000103 EF-hand domain pair; Region: EF_hand_5; pfam13499 391595000104 Ca2+ binding site [ion binding]; other site 391595000105 FOG: CBS domain [General function prediction only]; Region: COG0517 391595000106 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 391595000107 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 391595000108 BON domain; Region: BON; cl02771 391595000109 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 391595000110 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 391595000111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391595000112 EamA-like transporter family; Region: EamA; pfam00892 391595000113 EamA-like transporter family; Region: EamA; pfam00892 391595000114 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391595000115 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 391595000116 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 391595000117 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 391595000118 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 391595000119 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 391595000120 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 391595000121 Outer membrane efflux protein; Region: OEP; pfam02321 391595000122 Outer membrane efflux protein; Region: OEP; pfam02321 391595000123 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 391595000124 Domain of unknown function (DUF305); Region: DUF305; cl17794 391595000125 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 391595000126 Ion channel; Region: Ion_trans_2; pfam07885 391595000127 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391595000128 active site residue [active] 391595000129 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391595000130 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 391595000131 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 391595000132 DNA binding residues [nucleotide binding] 391595000133 dimer interface [polypeptide binding]; other site 391595000134 copper binding site [ion binding]; other site 391595000135 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391595000136 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391595000137 metal-binding site [ion binding] 391595000138 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391595000139 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391595000140 metal-binding site [ion binding] 391595000141 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391595000142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595000143 motif II; other site 391595000144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391595000145 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391595000146 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 391595000147 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 391595000148 catalytic residues [active] 391595000149 Cytochrome c; Region: Cytochrom_C; pfam00034 391595000150 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 391595000151 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 391595000152 Multicopper oxidase; Region: Cu-oxidase; pfam00394 391595000153 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 391595000154 Copper resistance protein D; Region: CopD; cl00563 391595000155 CopC domain; Region: CopC; pfam04234 391595000156 Cytochrome c; Region: Cytochrom_C; pfam00034 391595000157 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391595000158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391595000159 HAMP domain; Region: HAMP; pfam00672 391595000160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595000161 dimer interface [polypeptide binding]; other site 391595000162 phosphorylation site [posttranslational modification] 391595000163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595000164 ATP binding site [chemical binding]; other site 391595000165 Mg2+ binding site [ion binding]; other site 391595000166 G-X-G motif; other site 391595000167 osmolarity response regulator; Provisional; Region: ompR; PRK09468 391595000168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595000169 active site 391595000170 phosphorylation site [posttranslational modification] 391595000171 intermolecular recognition site; other site 391595000172 dimerization interface [polypeptide binding]; other site 391595000173 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391595000174 DNA binding site [nucleotide binding] 391595000175 BNR repeat-like domain; Region: BNR_2; pfam13088 391595000176 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 391595000177 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 391595000178 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 391595000179 [2Fe-2S] cluster binding site [ion binding]; other site 391595000180 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 391595000181 ParB-like nuclease domain; Region: ParBc; pfam02195 391595000182 Protein of unknown function (DUF736); Region: DUF736; pfam05284 391595000183 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 391595000184 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391595000185 P-loop; other site 391595000186 Magnesium ion binding site [ion binding]; other site 391595000187 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391595000188 Magnesium ion binding site [ion binding]; other site 391595000189 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 391595000190 ParB-like nuclease domain; Region: ParBc; pfam02195 391595000191 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 391595000192 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 391595000193 Substrate binding site; other site 391595000194 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 391595000195 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 391595000196 exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152 391595000197 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 391595000198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391595000199 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391595000200 Transposase; Region: HTH_Tnp_1; cl17663 391595000201 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 391595000202 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 391595000203 active site 391595000204 substrate binding site [chemical binding]; other site 391595000205 metal binding site [ion binding]; metal-binding site 391595000206 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 391595000207 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 391595000208 substrate binding site; other site 391595000209 tetramer interface; other site 391595000210 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 391595000211 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 391595000212 NADP binding site [chemical binding]; other site 391595000213 active site 391595000214 putative substrate binding site [chemical binding]; other site 391595000215 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 391595000216 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 391595000217 NAD binding site [chemical binding]; other site 391595000218 substrate binding site [chemical binding]; other site 391595000219 homodimer interface [polypeptide binding]; other site 391595000220 active site 391595000221 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 391595000222 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 391595000223 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 391595000224 NAD binding site [chemical binding]; other site 391595000225 homodimer interface [polypeptide binding]; other site 391595000226 active site 391595000227 substrate binding site [chemical binding]; other site 391595000228 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391595000229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595000230 NAD(P) binding site [chemical binding]; other site 391595000231 active site 391595000232 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 391595000233 ATP-sulfurylase; Region: ATPS; cd00517 391595000234 active site 391595000235 HXXH motif; other site 391595000236 flexible loop; other site 391595000237 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 391595000238 ligand-binding site [chemical binding]; other site 391595000239 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 391595000240 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391595000241 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391595000242 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 391595000243 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 391595000244 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 391595000245 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 391595000246 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 391595000247 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391595000248 active site 391595000249 Right handed beta helix region; Region: Beta_helix; pfam13229 391595000250 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 391595000251 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 391595000252 trimer interface [polypeptide binding]; other site 391595000253 active site 391595000254 substrate binding site [chemical binding]; other site 391595000255 CoA binding site [chemical binding]; other site 391595000256 biosynthesis cluster domain; Region: biosyn_clust_1; cl14822 391595000257 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391595000258 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391595000259 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 391595000260 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 391595000261 Probable Catalytic site; other site 391595000262 metal-binding site 391595000263 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 391595000264 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391595000265 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595000266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595000267 Walker A/P-loop; other site 391595000268 ATP binding site [chemical binding]; other site 391595000269 Q-loop/lid; other site 391595000270 ABC transporter signature motif; other site 391595000271 Walker B; other site 391595000272 D-loop; other site 391595000273 H-loop/switch region; other site 391595000274 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 391595000275 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 391595000276 active site 391595000277 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 391595000278 Right handed beta helix region; Region: Beta_helix; pfam13229 391595000279 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 391595000280 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391595000281 Bacterial sugar transferase; Region: Bac_transf; pfam02397 391595000282 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 391595000283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595000284 Walker A motif; other site 391595000285 ATP binding site [chemical binding]; other site 391595000286 Walker B motif; other site 391595000287 arginine finger; other site 391595000288 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 391595000289 AAA domain; Region: AAA_31; pfam13614 391595000290 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391595000291 Transposase; Region: HTH_Tnp_1; cl17663 391595000292 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 391595000293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 391595000294 TPR motif; other site 391595000295 binding surface 391595000296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595000297 TPR motif; other site 391595000298 binding surface 391595000299 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 391595000300 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 391595000301 SLBB domain; Region: SLBB; pfam10531 391595000302 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 391595000303 Rhomboid family; Region: Rhomboid; cl11446 391595000304 Replication initiator protein A; Region: RPA; pfam10134 391595000305 DnaA N-terminal domain; Region: DnaA_N; pfam11638 391595000306 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 391595000307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595000308 Walker A motif; other site 391595000309 ATP binding site [chemical binding]; other site 391595000310 Walker B motif; other site 391595000311 arginine finger; other site 391595000312 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 391595000313 DnaA box-binding interface [nucleotide binding]; other site 391595000314 DNA polymerase III subunit beta; Validated; Region: PRK05643 391595000315 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 391595000316 putative DNA binding surface [nucleotide binding]; other site 391595000317 dimer interface [polypeptide binding]; other site 391595000318 beta-clamp/clamp loader binding surface; other site 391595000319 beta-clamp/translesion DNA polymerase binding surface; other site 391595000320 recombination protein F; Reviewed; Region: recF; PRK00064 391595000321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595000322 Walker A/P-loop; other site 391595000323 ATP binding site [chemical binding]; other site 391595000324 Q-loop/lid; other site 391595000325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595000326 ABC transporter signature motif; other site 391595000327 Walker B; other site 391595000328 D-loop; other site 391595000329 H-loop/switch region; other site 391595000330 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391595000331 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 391595000332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595000333 Mg2+ binding site [ion binding]; other site 391595000334 G-X-G motif; other site 391595000335 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 391595000336 anchoring element; other site 391595000337 dimer interface [polypeptide binding]; other site 391595000338 ATP binding site [chemical binding]; other site 391595000339 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 391595000340 active site 391595000341 putative metal-binding site [ion binding]; other site 391595000342 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 391595000343 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 391595000344 catalytic residues [active] 391595000345 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 391595000346 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 391595000347 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 391595000348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595000349 FeS/SAM binding site; other site 391595000350 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 391595000351 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 391595000352 Fe-S cluster binding site [ion binding]; other site 391595000353 active site 391595000354 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595000355 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595000356 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391595000357 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 391595000358 intersubunit interface [polypeptide binding]; other site 391595000359 active site 391595000360 zinc binding site [ion binding]; other site 391595000361 Na+ binding site [ion binding]; other site 391595000362 KduI/IolB family; Region: KduI; pfam04962 391595000363 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391595000364 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391595000365 substrate binding site [chemical binding]; other site 391595000366 ATP binding site [chemical binding]; other site 391595000367 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 391595000368 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391595000369 dimer interface [polypeptide binding]; other site 391595000370 PYR/PP interface [polypeptide binding]; other site 391595000371 TPP binding site [chemical binding]; other site 391595000372 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391595000373 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391595000374 TPP-binding site [chemical binding]; other site 391595000375 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595000376 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595000377 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391595000378 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391595000379 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595000380 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595000381 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391595000382 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595000383 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391595000384 ligand binding site [chemical binding]; other site 391595000385 flexible hinge region; other site 391595000386 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 391595000387 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 391595000388 substrate binding site [chemical binding]; other site 391595000389 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391595000390 putative metal binding site [ion binding]; other site 391595000391 tartrate dehydrogenase; Region: TTC; TIGR02089 391595000392 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 391595000393 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595000394 EamA-like transporter family; Region: EamA; cl17759 391595000395 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391595000396 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391595000397 MatK/TrnK amino terminal region; Region: MatK_N; pfam01824 391595000398 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 391595000399 dimerization interface [polypeptide binding]; other site 391595000400 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391595000401 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391595000402 DNA binding site [nucleotide binding] 391595000403 domain linker motif; other site 391595000404 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 391595000405 putative dimerization interface [polypeptide binding]; other site 391595000406 putative ligand binding site [chemical binding]; other site 391595000407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 391595000408 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 391595000409 hypothetical protein; Provisional; Region: PRK07475 391595000410 MarR family; Region: MarR_2; cl17246 391595000411 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595000412 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391595000413 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595000414 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391595000415 DctM-like transporters; Region: DctM; pfam06808 391595000416 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391595000417 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 391595000418 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 391595000419 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 391595000420 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 391595000421 putative active site [active] 391595000422 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595000423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595000424 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391595000425 dimerization interface [polypeptide binding]; other site 391595000426 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 391595000427 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391595000428 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 391595000429 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 391595000430 Walker A/P-loop; other site 391595000431 ATP binding site [chemical binding]; other site 391595000432 Q-loop/lid; other site 391595000433 ABC transporter signature motif; other site 391595000434 Walker B; other site 391595000435 D-loop; other site 391595000436 H-loop/switch region; other site 391595000437 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 391595000438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595000439 dimer interface [polypeptide binding]; other site 391595000440 conserved gate region; other site 391595000441 putative PBP binding loops; other site 391595000442 ABC-ATPase subunit interface; other site 391595000443 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391595000444 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 391595000445 flagellar motor protein MotA; Validated; Region: PRK09110 391595000446 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 391595000447 Uncharacterized conserved protein [Function unknown]; Region: COG3334 391595000448 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 391595000449 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 391595000450 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 391595000451 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 391595000452 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 391595000453 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 391595000454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391595000455 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391595000456 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 391595000457 HlyD family secretion protein; Region: HlyD_3; pfam13437 391595000458 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 391595000459 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595000460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595000461 Walker A/P-loop; other site 391595000462 ATP binding site [chemical binding]; other site 391595000463 Q-loop/lid; other site 391595000464 ABC transporter signature motif; other site 391595000465 Walker B; other site 391595000466 D-loop; other site 391595000467 H-loop/switch region; other site 391595000468 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 391595000469 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595000470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595000471 Walker A/P-loop; other site 391595000472 ATP binding site [chemical binding]; other site 391595000473 Q-loop/lid; other site 391595000474 ABC transporter signature motif; other site 391595000475 Walker B; other site 391595000476 D-loop; other site 391595000477 H-loop/switch region; other site 391595000478 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 391595000479 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 391595000480 methionine sulfoxide reductase A; Provisional; Region: PRK14054 391595000481 methionine sulfoxide reductase B; Provisional; Region: PRK00222 391595000482 SelR domain; Region: SelR; pfam01641 391595000483 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 391595000484 catalytic residues [active] 391595000485 dimer interface [polypeptide binding]; other site 391595000486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595000487 S-adenosylmethionine binding site [chemical binding]; other site 391595000488 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391595000489 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391595000490 conserved cys residue [active] 391595000491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595000492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595000493 EamA-like transporter family; Region: EamA; pfam00892 391595000494 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391595000495 EamA-like transporter family; Region: EamA; pfam00892 391595000496 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391595000497 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391595000498 IHF dimer interface [polypeptide binding]; other site 391595000499 IHF - DNA interface [nucleotide binding]; other site 391595000500 AMP nucleosidase; Provisional; Region: PRK08292 391595000501 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 391595000502 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 391595000503 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 391595000504 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595000505 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 391595000506 active site 391595000507 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 391595000508 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 391595000509 active site 391595000510 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391595000511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595000512 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595000513 dimerization interface [polypeptide binding]; other site 391595000514 hypothetical protein; Provisional; Region: PRK07490 391595000515 intersubunit interface [polypeptide binding]; other site 391595000516 active site 391595000517 Zn2+ binding site [ion binding]; other site 391595000518 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 391595000519 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 391595000520 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391595000521 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391595000522 active site 391595000523 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 391595000524 CoA binding domain; Region: CoA_binding_2; pfam13380 391595000525 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 391595000526 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 391595000527 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 391595000528 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391595000529 substrate binding site [chemical binding]; other site 391595000530 oxyanion hole (OAH) forming residues; other site 391595000531 trimer interface [polypeptide binding]; other site 391595000532 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 391595000533 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391595000534 putative NAD(P) binding site [chemical binding]; other site 391595000535 VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370 391595000536 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 391595000537 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 391595000538 substrate binding site [chemical binding]; other site 391595000539 ligand binding site [chemical binding]; other site 391595000540 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391595000541 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 391595000542 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 391595000543 Protein of unknown function (DUF502); Region: DUF502; cl01107 391595000544 Protein of unknown function, DUF599; Region: DUF599; pfam04654 391595000545 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 391595000546 FAD binding domain; Region: FAD_binding_4; pfam01565 391595000547 FAD binding domain; Region: FAD_binding_4; pfam01565 391595000548 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 391595000549 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 391595000550 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391595000551 Cysteine-rich domain; Region: CCG; pfam02754 391595000552 Cysteine-rich domain; Region: CCG; pfam02754 391595000553 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 391595000554 active site 391595000555 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 391595000556 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 391595000557 putative dimer interface [polypeptide binding]; other site 391595000558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595000559 WHG domain; Region: WHG; pfam13305 391595000560 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 391595000561 hypothetical protein; Provisional; Region: PRK10756 391595000562 CreA protein; Region: CreA; pfam05981 391595000563 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 391595000564 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 391595000565 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 391595000566 putative active site [active] 391595000567 catalytic site [active] 391595000568 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 391595000569 PLD-like domain; Region: PLDc_2; pfam13091 391595000570 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 391595000571 putative active site [active] 391595000572 putative active site [active] 391595000573 catalytic site [active] 391595000574 catalytic site [active] 391595000575 Domain of unknown function DUF20; Region: UPF0118; pfam01594 391595000576 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 391595000577 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 391595000578 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 391595000579 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 391595000580 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 391595000581 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 391595000582 TrkA-N domain; Region: TrkA_N; pfam02254 391595000583 TrkA-C domain; Region: TrkA_C; pfam02080 391595000584 two-component response regulator; Provisional; Region: PRK09191 391595000585 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 391595000586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595000587 active site 391595000588 phosphorylation site [posttranslational modification] 391595000589 intermolecular recognition site; other site 391595000590 dimerization interface [polypeptide binding]; other site 391595000591 RNA polymerase sigma factor; Provisional; Region: PRK12546 391595000592 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391595000593 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391595000594 DNA binding residues [nucleotide binding] 391595000595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 391595000596 Histidine kinase; Region: HisKA_2; pfam07568 391595000597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595000598 ATP binding site [chemical binding]; other site 391595000599 Mg2+ binding site [ion binding]; other site 391595000600 G-X-G motif; other site 391595000601 acetolactate synthase; Reviewed; Region: PRK08322 391595000602 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391595000603 PYR/PP interface [polypeptide binding]; other site 391595000604 dimer interface [polypeptide binding]; other site 391595000605 TPP binding site [chemical binding]; other site 391595000606 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391595000607 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391595000608 TPP-binding site [chemical binding]; other site 391595000609 glutamate dehydrogenase; Provisional; Region: PRK09414 391595000610 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 391595000611 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 391595000612 NAD(P) binding pocket [chemical binding]; other site 391595000613 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391595000614 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595000615 ligand binding site [chemical binding]; other site 391595000616 flexible hinge region; other site 391595000617 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 391595000618 non-specific DNA interactions [nucleotide binding]; other site 391595000619 DNA binding site [nucleotide binding] 391595000620 sequence specific DNA binding site [nucleotide binding]; other site 391595000621 putative cAMP binding site [chemical binding]; other site 391595000622 mechanosensitive channel MscS; Provisional; Region: PRK10334 391595000623 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391595000624 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 391595000625 BON domain; Region: BON; pfam04972 391595000626 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391595000627 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391595000628 PRC-barrel domain; Region: PRC; pfam05239 391595000629 glutathione reductase; Validated; Region: PRK06116 391595000630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595000631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391595000632 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391595000633 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391595000634 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 391595000635 putative NAD(P) binding site [chemical binding]; other site 391595000636 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391595000637 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391595000638 active site 391595000639 metal binding site [ion binding]; metal-binding site 391595000640 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391595000641 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 391595000642 putative dimer interface [polypeptide binding]; other site 391595000643 putative GSH binding site (G-site) [chemical binding]; other site 391595000644 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 391595000645 dimer interface [polypeptide binding]; other site 391595000646 N-terminal domain interface [polypeptide binding]; other site 391595000647 substrate binding pocket (H-site) [chemical binding]; other site 391595000648 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391595000649 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 391595000650 NAD(P) binding site [chemical binding]; other site 391595000651 catalytic residues [active] 391595000652 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 391595000653 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 391595000654 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 391595000655 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 391595000656 active site 391595000657 DNA binding site [nucleotide binding] 391595000658 Int/Topo IB signature motif; other site 391595000659 catalytic residues [active] 391595000660 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 391595000661 dimerization interface [polypeptide binding]; other site 391595000662 metal binding site [ion binding]; metal-binding site 391595000663 CsbD-like; Region: CsbD; cl17424 391595000664 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 391595000665 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 391595000666 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391595000667 tetramerization interface [polypeptide binding]; other site 391595000668 NAD(P) binding site [chemical binding]; other site 391595000669 catalytic residues [active] 391595000670 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 391595000671 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 391595000672 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391595000673 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391595000674 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391595000675 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 391595000676 active site 391595000677 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 391595000678 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 391595000679 nucleotide binding site/active site [active] 391595000680 HIT family signature motif; other site 391595000681 catalytic residue [active] 391595000682 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 391595000683 SmpB-tmRNA interface; other site 391595000684 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 391595000685 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 391595000686 active site residue [active] 391595000687 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 391595000688 active site residue [active] 391595000689 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 391595000690 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391595000691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595000692 homodimer interface [polypeptide binding]; other site 391595000693 catalytic residue [active] 391595000694 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 391595000695 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391595000696 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 391595000697 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 391595000698 Nitrogen regulatory protein P-II; Region: P-II; smart00938 391595000699 Transglycosylase; Region: Transgly; pfam00912 391595000700 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 391595000701 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 391595000702 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 391595000703 VacJ like lipoprotein; Region: VacJ; cl01073 391595000704 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 391595000705 homotrimer interaction site [polypeptide binding]; other site 391595000706 putative active site [active] 391595000707 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 391595000708 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 391595000709 active site 391595000710 catalytic site [active] 391595000711 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 391595000712 Protein of unknown function, DUF482; Region: DUF482; pfam04339 391595000713 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 391595000714 aromatic arch; other site 391595000715 DCoH dimer interaction site [polypeptide binding]; other site 391595000716 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 391595000717 DCoH tetramer interaction site [polypeptide binding]; other site 391595000718 substrate binding site [chemical binding]; other site 391595000719 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391595000720 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 391595000721 catalytic triad [active] 391595000722 dimer interface [polypeptide binding]; other site 391595000723 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 391595000724 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595000725 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391595000726 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 391595000727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595000728 S-adenosylmethionine binding site [chemical binding]; other site 391595000729 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 391595000730 active site 391595000731 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 391595000732 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 391595000733 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 391595000734 putative MPT binding site; other site 391595000735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391595000736 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 391595000737 Coenzyme A binding pocket [chemical binding]; other site 391595000738 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 391595000739 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 391595000740 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391595000741 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391595000742 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391595000743 ligand binding site [chemical binding]; other site 391595000744 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595000745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595000746 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391595000747 putative effector binding pocket; other site 391595000748 dimerization interface [polypeptide binding]; other site 391595000749 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 391595000750 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 391595000751 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 391595000752 active site 391595000753 FMN binding site [chemical binding]; other site 391595000754 2,4-decadienoyl-CoA binding site; other site 391595000755 catalytic residue [active] 391595000756 4Fe-4S cluster binding site [ion binding]; other site 391595000757 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 391595000758 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595000759 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 391595000760 putative active site [active] 391595000761 Ap4A binding site [chemical binding]; other site 391595000762 nudix motif; other site 391595000763 putative metal binding site [ion binding]; other site 391595000764 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 391595000765 Coenzyme A binding pocket [chemical binding]; other site 391595000766 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 391595000767 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391595000768 substrate binding site [chemical binding]; other site 391595000769 ATP binding site [chemical binding]; other site 391595000770 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 391595000771 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391595000772 minor groove reading motif; other site 391595000773 helix-hairpin-helix signature motif; other site 391595000774 substrate binding pocket [chemical binding]; other site 391595000775 active site 391595000776 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 391595000777 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595000778 Helix-turn-helix domain; Region: HTH_18; pfam12833 391595000779 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 391595000780 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 391595000781 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 391595000782 DNA binding site [nucleotide binding] 391595000783 active site 391595000784 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391595000785 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391595000786 ligand binding site [chemical binding]; other site 391595000787 Predicted flavoprotein [General function prediction only]; Region: COG0431 391595000788 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391595000789 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595000790 Uncharacterized conserved protein [Function unknown]; Region: COG4121 391595000791 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391595000792 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391595000793 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391595000794 catalytic residue [active] 391595000795 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391595000796 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 391595000797 dimer interface [polypeptide binding]; other site 391595000798 active site 391595000799 catalytic residue [active] 391595000800 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 391595000801 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 391595000802 4Fe-4S binding domain; Region: Fer4; pfam00037 391595000803 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 391595000804 The MopB_2 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_2; cd02763 391595000805 putative [Fe4-S4] binding site [ion binding]; other site 391595000806 putative molybdopterin cofactor binding site [chemical binding]; other site 391595000807 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 391595000808 putative molybdopterin cofactor binding site; other site 391595000809 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 391595000810 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 391595000811 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391595000812 PYR/PP interface [polypeptide binding]; other site 391595000813 dimer interface [polypeptide binding]; other site 391595000814 TPP binding site [chemical binding]; other site 391595000815 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391595000816 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391595000817 TPP-binding site [chemical binding]; other site 391595000818 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391595000819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595000820 DNA-binding site [nucleotide binding]; DNA binding site 391595000821 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391595000822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595000823 homodimer interface [polypeptide binding]; other site 391595000824 catalytic residue [active] 391595000825 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 391595000826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 391595000827 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391595000828 aminotransferase; Validated; Region: PRK07678 391595000829 inhibitor-cofactor binding pocket; inhibition site 391595000830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595000831 catalytic residue [active] 391595000832 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 391595000833 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 391595000834 substrate binding pocket [chemical binding]; other site 391595000835 membrane-bound complex binding site; other site 391595000836 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391595000837 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391595000838 Walker A/P-loop; other site 391595000839 ATP binding site [chemical binding]; other site 391595000840 Q-loop/lid; other site 391595000841 ABC transporter signature motif; other site 391595000842 Walker B; other site 391595000843 D-loop; other site 391595000844 H-loop/switch region; other site 391595000845 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391595000846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595000847 dimer interface [polypeptide binding]; other site 391595000848 conserved gate region; other site 391595000849 putative PBP binding loops; other site 391595000850 ABC-ATPase subunit interface; other site 391595000851 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 391595000852 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 391595000853 putative di-iron ligands [ion binding]; other site 391595000854 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391595000855 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 391595000856 ATP binding site [chemical binding]; other site 391595000857 putative Mg++ binding site [ion binding]; other site 391595000858 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391595000859 nucleotide binding region [chemical binding]; other site 391595000860 ATP-binding site [chemical binding]; other site 391595000861 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 391595000862 RNA binding site [nucleotide binding]; other site 391595000863 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391595000864 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 391595000865 homodimer interface [polypeptide binding]; other site 391595000866 substrate-cofactor binding pocket; other site 391595000867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595000868 catalytic residue [active] 391595000869 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 391595000870 FOG: WD40 repeat [General function prediction only]; Region: COG2319 391595000871 structural tetrad; other site 391595000872 Cytochrome c; Region: Cytochrom_C; cl11414 391595000873 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595000874 dimerization interface [polypeptide binding]; other site 391595000875 putative DNA binding site [nucleotide binding]; other site 391595000876 putative Zn2+ binding site [ion binding]; other site 391595000877 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 391595000878 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 391595000879 putative active site [active] 391595000880 putative FMN binding site [chemical binding]; other site 391595000881 putative substrate binding site [chemical binding]; other site 391595000882 putative catalytic residue [active] 391595000883 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 391595000884 TIGR02300 family protein; Region: FYDLN_acid 391595000885 Protein of unknown function DUF45; Region: DUF45; pfam01863 391595000886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595000887 DNA-binding site [nucleotide binding]; DNA binding site 391595000888 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 391595000889 FCD domain; Region: FCD; pfam07729 391595000890 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 391595000891 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 391595000892 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391595000893 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595000894 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595000895 putative DNA binding site [nucleotide binding]; other site 391595000896 putative Zn2+ binding site [ion binding]; other site 391595000897 AsnC family; Region: AsnC_trans_reg; pfam01037 391595000898 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 391595000899 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 391595000900 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 391595000901 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 391595000902 active site 391595000903 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391595000904 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 391595000905 homodimer interface [polypeptide binding]; other site 391595000906 substrate-cofactor binding pocket; other site 391595000907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595000908 catalytic residue [active] 391595000909 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 391595000910 putative active site [active] 391595000911 putative catalytic site [active] 391595000912 Protein of unknown function (DUF1244); Region: DUF1244; pfam06844 391595000913 pyruvate kinase; Provisional; Region: PRK06247 391595000914 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 391595000915 domain interfaces; other site 391595000916 active site 391595000917 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 391595000918 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 391595000919 23S rRNA binding site [nucleotide binding]; other site 391595000920 L21 binding site [polypeptide binding]; other site 391595000921 L13 binding site [polypeptide binding]; other site 391595000922 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; pfam10707 391595000923 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 391595000924 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 391595000925 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 391595000926 dimer interface [polypeptide binding]; other site 391595000927 motif 1; other site 391595000928 active site 391595000929 motif 2; other site 391595000930 motif 3; other site 391595000931 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 391595000932 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 391595000933 putative tRNA-binding site [nucleotide binding]; other site 391595000934 B3/4 domain; Region: B3_4; pfam03483 391595000935 tRNA synthetase B5 domain; Region: B5; smart00874 391595000936 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 391595000937 dimer interface [polypeptide binding]; other site 391595000938 motif 1; other site 391595000939 motif 3; other site 391595000940 motif 2; other site 391595000941 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 391595000942 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071 391595000943 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 391595000944 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 391595000945 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391595000946 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 391595000947 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 391595000948 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391595000949 Virulence factor SrfB; Region: SrfB; pfam07520 391595000950 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391595000951 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391595000952 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 391595000953 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 391595000954 metal ion-dependent adhesion site (MIDAS); other site 391595000955 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 391595000956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595000957 Walker A/P-loop; other site 391595000958 ATP binding site [chemical binding]; other site 391595000959 Q-loop/lid; other site 391595000960 ABC transporter signature motif; other site 391595000961 Walker B; other site 391595000962 D-loop; other site 391595000963 H-loop/switch region; other site 391595000964 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 391595000965 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391595000966 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 391595000967 [2Fe-2S] cluster binding site [ion binding]; other site 391595000968 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 391595000969 putative alpha subunit interface [polypeptide binding]; other site 391595000970 putative active site [active] 391595000971 putative substrate binding site [chemical binding]; other site 391595000972 Fe binding site [ion binding]; other site 391595000973 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 391595000974 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 391595000975 hexamer interface [polypeptide binding]; other site 391595000976 ligand binding site [chemical binding]; other site 391595000977 putative active site [active] 391595000978 NAD(P) binding site [chemical binding]; other site 391595000979 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595000980 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595000981 putative DNA binding site [nucleotide binding]; other site 391595000982 putative Zn2+ binding site [ion binding]; other site 391595000983 AsnC family; Region: AsnC_trans_reg; pfam01037 391595000984 Zc3h12a-like Ribonuclease NYN domain; Region: RNase_Zc3h12a; pfam11977 391595000985 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 391595000986 putative active site [active] 391595000987 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 391595000988 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 391595000989 COQ9; Region: COQ9; pfam08511 391595000990 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 391595000991 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 391595000992 NAD(P) binding site [chemical binding]; other site 391595000993 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 391595000994 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 391595000995 NADP binding site [chemical binding]; other site 391595000996 dimer interface [polypeptide binding]; other site 391595000997 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 391595000998 B1 nucleotide binding pocket [chemical binding]; other site 391595000999 B2 nucleotide binding pocket [chemical binding]; other site 391595001000 CAS motifs; other site 391595001001 active site 391595001002 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 391595001003 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 391595001004 homotrimer interaction site [polypeptide binding]; other site 391595001005 putative active site [active] 391595001006 recombination protein RecR; Reviewed; Region: recR; PRK00076 391595001007 RecR protein; Region: RecR; pfam02132 391595001008 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 391595001009 putative active site [active] 391595001010 putative metal-binding site [ion binding]; other site 391595001011 tetramer interface [polypeptide binding]; other site 391595001012 hypothetical protein; Validated; Region: PRK00153 391595001013 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 391595001014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595001015 Walker A motif; other site 391595001016 ATP binding site [chemical binding]; other site 391595001017 Walker B motif; other site 391595001018 arginine finger; other site 391595001019 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 391595001020 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 391595001021 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 391595001022 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 391595001023 putative NAD(P) binding site [chemical binding]; other site 391595001024 catalytic Zn binding site [ion binding]; other site 391595001025 DctM-like transporters; Region: DctM; pfam06808 391595001026 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391595001027 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 391595001028 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391595001029 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 391595001030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595001031 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391595001032 DNA-binding site [nucleotide binding]; DNA binding site 391595001033 FCD domain; Region: FCD; pfam07729 391595001034 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 391595001035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595001036 ABC-ATPase subunit interface; other site 391595001037 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 391595001038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595001039 dimer interface [polypeptide binding]; other site 391595001040 conserved gate region; other site 391595001041 ABC-ATPase subunit interface; other site 391595001042 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 391595001043 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 391595001044 Walker A/P-loop; other site 391595001045 ATP binding site [chemical binding]; other site 391595001046 Q-loop/lid; other site 391595001047 ABC transporter signature motif; other site 391595001048 Walker B; other site 391595001049 D-loop; other site 391595001050 H-loop/switch region; other site 391595001051 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 391595001052 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391595001053 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 391595001054 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391595001055 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 391595001056 nudix motif; other site 391595001057 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391595001058 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391595001059 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 391595001060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595001061 dimer interface [polypeptide binding]; other site 391595001062 conserved gate region; other site 391595001063 putative PBP binding loops; other site 391595001064 ABC-ATPase subunit interface; other site 391595001065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595001066 dimer interface [polypeptide binding]; other site 391595001067 conserved gate region; other site 391595001068 putative PBP binding loops; other site 391595001069 ABC-ATPase subunit interface; other site 391595001070 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595001071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595001072 Walker A/P-loop; other site 391595001073 ATP binding site [chemical binding]; other site 391595001074 Q-loop/lid; other site 391595001075 ABC transporter signature motif; other site 391595001076 Walker B; other site 391595001077 D-loop; other site 391595001078 H-loop/switch region; other site 391595001079 TOBE domain; Region: TOBE_2; pfam08402 391595001080 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391595001081 catalytic core [active] 391595001082 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 391595001083 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 391595001084 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 391595001085 hinge; other site 391595001086 active site 391595001087 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 391595001088 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 391595001089 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391595001090 NAD binding site [chemical binding]; other site 391595001091 dimerization interface [polypeptide binding]; other site 391595001092 product binding site; other site 391595001093 substrate binding site [chemical binding]; other site 391595001094 zinc binding site [ion binding]; other site 391595001095 catalytic residues [active] 391595001096 hypothetical protein; Provisional; Region: PRK02853 391595001097 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 391595001098 Low molecular weight phosphatase family; Region: LMWPc; cd00115 391595001099 active site 391595001100 Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816 391595001101 substrate binding site [chemical binding]; other site 391595001102 homodimer interface [polypeptide binding]; other site 391595001103 heme binding site [chemical binding]; other site 391595001104 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 391595001105 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391595001106 GTP-binding protein LepA; Provisional; Region: PRK05433 391595001107 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 391595001108 G1 box; other site 391595001109 putative GEF interaction site [polypeptide binding]; other site 391595001110 GTP/Mg2+ binding site [chemical binding]; other site 391595001111 Switch I region; other site 391595001112 G2 box; other site 391595001113 G3 box; other site 391595001114 Switch II region; other site 391595001115 G4 box; other site 391595001116 G5 box; other site 391595001117 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 391595001118 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 391595001119 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 391595001120 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 391595001121 S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692 391595001122 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 391595001123 NodB motif; other site 391595001124 putative active site [active] 391595001125 putative catalytic site [active] 391595001126 putative Zn binding site [ion binding]; other site 391595001127 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 391595001128 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391595001129 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391595001130 catalytic core [active] 391595001131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391595001132 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391595001133 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 391595001134 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 391595001135 putative ADP-binding pocket [chemical binding]; other site 391595001136 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 391595001137 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391595001138 Helix-turn-helix domain; Region: HTH_18; pfam12833 391595001139 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 391595001140 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391595001141 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391595001142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595001143 dimer interface [polypeptide binding]; other site 391595001144 conserved gate region; other site 391595001145 putative PBP binding loops; other site 391595001146 ABC-ATPase subunit interface; other site 391595001147 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391595001148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391595001149 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 391595001150 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391595001151 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391595001152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595001153 Walker A/P-loop; other site 391595001154 ATP binding site [chemical binding]; other site 391595001155 Q-loop/lid; other site 391595001156 ABC transporter signature motif; other site 391595001157 Walker B; other site 391595001158 D-loop; other site 391595001159 H-loop/switch region; other site 391595001160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391595001161 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595001162 Walker A/P-loop; other site 391595001163 ATP binding site [chemical binding]; other site 391595001164 Q-loop/lid; other site 391595001165 ABC transporter signature motif; other site 391595001166 Walker B; other site 391595001167 D-loop; other site 391595001168 H-loop/switch region; other site 391595001169 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391595001170 S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692 391595001171 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 391595001172 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 391595001173 substrate binding site [chemical binding]; other site 391595001174 hexamer interface [polypeptide binding]; other site 391595001175 metal binding site [ion binding]; metal-binding site 391595001176 AMP-binding domain protein; Validated; Region: PRK08315 391595001177 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391595001178 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 391595001179 acyl-activating enzyme (AAE) consensus motif; other site 391595001180 putative AMP binding site [chemical binding]; other site 391595001181 putative active site [active] 391595001182 putative CoA binding site [chemical binding]; other site 391595001183 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391595001184 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 391595001185 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 391595001186 putative NAD(P) binding site [chemical binding]; other site 391595001187 catalytic Zn binding site [ion binding]; other site 391595001188 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 391595001189 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 391595001190 NADP binding site [chemical binding]; other site 391595001191 homodimer interface [polypeptide binding]; other site 391595001192 active site 391595001193 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 391595001194 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 391595001195 active site 391595001196 catalytic site [active] 391595001197 substrate binding site [chemical binding]; other site 391595001198 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 391595001199 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595001200 ligand binding site [chemical binding]; other site 391595001201 flexible hinge region; other site 391595001202 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 391595001203 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391595001204 metal binding triad; other site 391595001205 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 391595001206 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 391595001207 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 391595001208 Na binding site [ion binding]; other site 391595001209 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 391595001210 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 391595001211 adenylate kinase; Reviewed; Region: adk; PRK00279 391595001212 AMP-binding site [chemical binding]; other site 391595001213 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 391595001214 acetyl-CoA synthetase; Provisional; Region: PRK00174 391595001215 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 391595001216 active site 391595001217 CoA binding site [chemical binding]; other site 391595001218 acyl-activating enzyme (AAE) consensus motif; other site 391595001219 AMP binding site [chemical binding]; other site 391595001220 acetate binding site [chemical binding]; other site 391595001221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391595001222 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391595001223 Predicted permeases [General function prediction only]; Region: RarD; COG2962 391595001224 EamA-like transporter family; Region: EamA; pfam00892 391595001225 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391595001226 murein hydrolase B; Provisional; Region: PRK10760; cl17906 391595001227 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391595001228 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595001229 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 391595001230 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 391595001231 HlyD family secretion protein; Region: HlyD_3; pfam13437 391595001232 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 391595001233 putative active site [active] 391595001234 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 391595001235 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595001236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595001237 Walker A/P-loop; other site 391595001238 ATP binding site [chemical binding]; other site 391595001239 Q-loop/lid; other site 391595001240 ABC transporter signature motif; other site 391595001241 Walker B; other site 391595001242 D-loop; other site 391595001243 H-loop/switch region; other site 391595001244 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 391595001245 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391595001246 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391595001247 ligand binding site [chemical binding]; other site 391595001248 hypothetical protein; Provisional; Region: PRK11171 391595001249 Cupin domain; Region: Cupin_2; pfam07883 391595001250 Cupin domain; Region: Cupin_2; pfam07883 391595001251 xanthine permease; Region: pbuX; TIGR03173 391595001252 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 391595001253 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 391595001254 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 391595001255 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 391595001256 active site 391595001257 catalytic site [active] 391595001258 tetramer interface [polypeptide binding]; other site 391595001259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 391595001260 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 391595001261 active site 391595001262 homotetramer interface [polypeptide binding]; other site 391595001263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595001264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595001265 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391595001266 putative effector binding pocket; other site 391595001267 dimerization interface [polypeptide binding]; other site 391595001268 Predicted membrane protein [Function unknown]; Region: COG3748 391595001269 Protein of unknown function (DUF989); Region: DUF989; pfam06181 391595001270 Cytochrome c; Region: Cytochrom_C; pfam00034 391595001271 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 391595001272 amidase catalytic site [active] 391595001273 Zn binding residues [ion binding]; other site 391595001274 substrate binding site [chemical binding]; other site 391595001275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595001276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595001277 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595001278 dimerization interface [polypeptide binding]; other site 391595001279 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 391595001280 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 391595001281 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391595001282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 391595001283 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 391595001284 acetylornithine deacetylase; Provisional; Region: PRK07522 391595001285 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 391595001286 metal binding site [ion binding]; metal-binding site 391595001287 putative dimer interface [polypeptide binding]; other site 391595001288 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 391595001289 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 391595001290 FMN binding site [chemical binding]; other site 391595001291 active site 391595001292 homodimer interface [polypeptide binding]; other site 391595001293 putative catalytic residue [active] 391595001294 4Fe-4S cluster binding site [ion binding]; other site 391595001295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391595001296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391595001297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595001298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595001299 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 391595001300 putative substrate binding pocket [chemical binding]; other site 391595001301 dimerization interface [polypeptide binding]; other site 391595001302 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 391595001303 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391595001304 homotrimer interaction site [polypeptide binding]; other site 391595001305 putative active site [active] 391595001306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595001307 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 391595001308 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 391595001309 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 391595001310 active site 391595001311 Zn binding site [ion binding]; other site 391595001312 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391595001313 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391595001314 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595001315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595001316 dimer interface [polypeptide binding]; other site 391595001317 conserved gate region; other site 391595001318 putative PBP binding loops; other site 391595001319 ABC-ATPase subunit interface; other site 391595001320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595001321 dimer interface [polypeptide binding]; other site 391595001322 conserved gate region; other site 391595001323 putative PBP binding loops; other site 391595001324 ABC-ATPase subunit interface; other site 391595001325 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595001326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595001327 Walker A/P-loop; other site 391595001328 ATP binding site [chemical binding]; other site 391595001329 Q-loop/lid; other site 391595001330 ABC transporter signature motif; other site 391595001331 Walker B; other site 391595001332 D-loop; other site 391595001333 H-loop/switch region; other site 391595001334 TOBE domain; Region: TOBE_2; pfam08402 391595001335 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391595001336 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391595001337 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 391595001338 active site 391595001339 VCBS repeat; Region: VCBS_repeat; TIGR01965 391595001340 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595001341 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391595001342 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595001343 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391595001344 Walker A/P-loop; other site 391595001345 ATP binding site [chemical binding]; other site 391595001346 Q-loop/lid; other site 391595001347 ABC transporter signature motif; other site 391595001348 Walker B; other site 391595001349 D-loop; other site 391595001350 H-loop/switch region; other site 391595001351 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595001352 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391595001353 Walker A/P-loop; other site 391595001354 ATP binding site [chemical binding]; other site 391595001355 Q-loop/lid; other site 391595001356 ABC transporter signature motif; other site 391595001357 Walker B; other site 391595001358 D-loop; other site 391595001359 H-loop/switch region; other site 391595001360 TOBE domain; Region: TOBE_2; pfam08402 391595001361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595001362 dimer interface [polypeptide binding]; other site 391595001363 conserved gate region; other site 391595001364 putative PBP binding loops; other site 391595001365 ABC-ATPase subunit interface; other site 391595001366 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595001367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595001368 dimer interface [polypeptide binding]; other site 391595001369 conserved gate region; other site 391595001370 ABC-ATPase subunit interface; other site 391595001371 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 391595001372 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 391595001373 Penicillinase repressor; Region: Pencillinase_R; pfam03965 391595001374 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 391595001375 hypothetical protein; Provisional; Region: PRK07483 391595001376 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391595001377 inhibitor-cofactor binding pocket; inhibition site 391595001378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595001379 catalytic residue [active] 391595001380 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595001381 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391595001382 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391595001383 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595001384 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391595001385 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 391595001386 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 391595001387 putative active site [active] 391595001388 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 391595001389 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391595001390 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 391595001391 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 391595001392 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 391595001393 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 391595001394 Ligand Binding Site [chemical binding]; other site 391595001395 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391595001396 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 391595001397 catalytic residues [active] 391595001398 catalytic nucleophile [active] 391595001399 Recombinase; Region: Recombinase; pfam07508 391595001400 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 391595001401 Recombinase; Region: Recombinase; pfam07508 391595001402 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 391595001403 Uncharacterized conserved protein [Function unknown]; Region: COG2308 391595001404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 391595001405 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 391595001406 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 391595001407 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 391595001408 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 391595001409 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391595001410 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 391595001411 Bacterial transcriptional regulator; Region: IclR; pfam01614 391595001412 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391595001413 DctM-like transporters; Region: DctM; pfam06808 391595001414 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391595001415 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391595001416 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595001417 choline dehydrogenase; Validated; Region: PRK02106 391595001418 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391595001419 reductive dehalogenase; Region: RDH; TIGR02486 391595001420 reductive dehalogenase; Region: RDH; TIGR02486 391595001421 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391595001422 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 391595001423 FMN-binding pocket [chemical binding]; other site 391595001424 flavin binding motif; other site 391595001425 phosphate binding motif [ion binding]; other site 391595001426 beta-alpha-beta structure motif; other site 391595001427 NAD binding pocket [chemical binding]; other site 391595001428 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391595001429 catalytic loop [active] 391595001430 iron binding site [ion binding]; other site 391595001431 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 391595001432 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391595001433 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 391595001434 NAD(P) binding site [chemical binding]; other site 391595001435 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 391595001436 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595001437 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 391595001438 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 391595001439 Walker A/P-loop; other site 391595001440 ATP binding site [chemical binding]; other site 391595001441 Q-loop/lid; other site 391595001442 ABC transporter signature motif; other site 391595001443 Walker B; other site 391595001444 D-loop; other site 391595001445 H-loop/switch region; other site 391595001446 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391595001447 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 391595001448 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 391595001449 tandem repeat interface [polypeptide binding]; other site 391595001450 oligomer interface [polypeptide binding]; other site 391595001451 active site residues [active] 391595001452 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 391595001453 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 391595001454 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 391595001455 short chain dehydrogenase; Provisional; Region: PRK09134 391595001456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595001457 NAD(P) binding site [chemical binding]; other site 391595001458 active site 391595001459 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 391595001460 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 391595001461 GIY-YIG motif/motif A; other site 391595001462 active site 391595001463 catalytic site [active] 391595001464 putative DNA binding site [nucleotide binding]; other site 391595001465 metal binding site [ion binding]; metal-binding site 391595001466 UvrB/uvrC motif; Region: UVR; pfam02151 391595001467 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 391595001468 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 391595001469 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 391595001470 MoaE interaction surface [polypeptide binding]; other site 391595001471 MoeB interaction surface [polypeptide binding]; other site 391595001472 thiocarboxylated glycine; other site 391595001473 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 391595001474 MoaE homodimer interface [polypeptide binding]; other site 391595001475 MoaD interaction [polypeptide binding]; other site 391595001476 active site residues [active] 391595001477 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391595001478 Ligand Binding Site [chemical binding]; other site 391595001479 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 391595001480 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391595001481 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391595001482 ligand binding site [chemical binding]; other site 391595001483 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 391595001484 UbiA prenyltransferase family; Region: UbiA; pfam01040 391595001485 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 391595001486 RNA methyltransferase, RsmE family; Region: TIGR00046 391595001487 glutamate--cysteine ligase; Region: PLN02611 391595001488 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391595001489 Ligand Binding Site [chemical binding]; other site 391595001490 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391595001491 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 391595001492 putative ligand binding site [chemical binding]; other site 391595001493 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595001494 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 391595001495 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391595001496 TM-ABC transporter signature motif; other site 391595001497 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595001498 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391595001499 TM-ABC transporter signature motif; other site 391595001500 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391595001501 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391595001502 Walker A/P-loop; other site 391595001503 ATP binding site [chemical binding]; other site 391595001504 Q-loop/lid; other site 391595001505 ABC transporter signature motif; other site 391595001506 Walker B; other site 391595001507 D-loop; other site 391595001508 H-loop/switch region; other site 391595001509 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391595001510 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 391595001511 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391595001512 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391595001513 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 391595001514 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391595001515 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391595001516 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 391595001517 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391595001518 catalytic loop [active] 391595001519 iron binding site [ion binding]; other site 391595001520 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391595001521 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 391595001522 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 391595001523 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 391595001524 putative active site [active] 391595001525 putative PHP Thumb interface [polypeptide binding]; other site 391595001526 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 391595001527 generic binding surface II; other site 391595001528 generic binding surface I; other site 391595001529 SlyX; Region: SlyX; pfam04102 391595001530 histidyl-tRNA synthetase; Region: hisS; TIGR00442 391595001531 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 391595001532 dimer interface [polypeptide binding]; other site 391595001533 motif 1; other site 391595001534 motif 2; other site 391595001535 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391595001536 active site 391595001537 motif 3; other site 391595001538 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 391595001539 anticodon binding site; other site 391595001540 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 391595001541 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391595001542 motif 1; other site 391595001543 dimer interface [polypeptide binding]; other site 391595001544 active site 391595001545 motif 2; other site 391595001546 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391595001547 active site 391595001548 motif 3; other site 391595001549 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 391595001550 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 391595001551 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 391595001552 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 391595001553 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 391595001554 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 391595001555 active site 391595001556 dimer interface [polypeptide binding]; other site 391595001557 effector binding site; other site 391595001558 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595001559 salt bridge; other site 391595001560 non-specific DNA binding site [nucleotide binding]; other site 391595001561 sequence-specific DNA binding site [nucleotide binding]; other site 391595001562 TSCPD domain; Region: TSCPD; pfam12637 391595001563 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 391595001564 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 391595001565 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 391595001566 putative homodimer interface [polypeptide binding]; other site 391595001567 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 391595001568 heterodimer interface [polypeptide binding]; other site 391595001569 homodimer interface [polypeptide binding]; other site 391595001570 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 391595001571 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 391595001572 23S rRNA interface [nucleotide binding]; other site 391595001573 L7/L12 interface [polypeptide binding]; other site 391595001574 putative thiostrepton binding site; other site 391595001575 L25 interface [polypeptide binding]; other site 391595001576 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 391595001577 mRNA/rRNA interface [nucleotide binding]; other site 391595001578 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 391595001579 23S rRNA interface [nucleotide binding]; other site 391595001580 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 391595001581 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 391595001582 core dimer interface [polypeptide binding]; other site 391595001583 peripheral dimer interface [polypeptide binding]; other site 391595001584 L10 interface [polypeptide binding]; other site 391595001585 L11 interface [polypeptide binding]; other site 391595001586 putative EF-Tu interaction site [polypeptide binding]; other site 391595001587 putative EF-G interaction site [polypeptide binding]; other site 391595001588 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 391595001589 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 391595001590 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 391595001591 RPB11 interaction site [polypeptide binding]; other site 391595001592 RPB12 interaction site [polypeptide binding]; other site 391595001593 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 391595001594 RPB3 interaction site [polypeptide binding]; other site 391595001595 RPB1 interaction site [polypeptide binding]; other site 391595001596 RPB11 interaction site [polypeptide binding]; other site 391595001597 RPB10 interaction site [polypeptide binding]; other site 391595001598 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 391595001599 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 391595001600 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 391595001601 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 391595001602 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 391595001603 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 391595001604 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 391595001605 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 391595001606 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 391595001607 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 391595001608 DNA binding site [nucleotide binding] 391595001609 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 391595001610 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595001611 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 391595001612 S17 interaction site [polypeptide binding]; other site 391595001613 S8 interaction site; other site 391595001614 16S rRNA interaction site [nucleotide binding]; other site 391595001615 streptomycin interaction site [chemical binding]; other site 391595001616 23S rRNA interaction site [nucleotide binding]; other site 391595001617 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 391595001618 30S ribosomal protein S7; Validated; Region: PRK05302 391595001619 elongation factor G; Reviewed; Region: PRK00007 391595001620 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 391595001621 G1 box; other site 391595001622 putative GEF interaction site [polypeptide binding]; other site 391595001623 GTP/Mg2+ binding site [chemical binding]; other site 391595001624 Switch I region; other site 391595001625 G2 box; other site 391595001626 G3 box; other site 391595001627 Switch II region; other site 391595001628 G4 box; other site 391595001629 G5 box; other site 391595001630 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 391595001631 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 391595001632 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 391595001633 elongation factor Tu; Reviewed; Region: PRK00049 391595001634 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 391595001635 G1 box; other site 391595001636 GEF interaction site [polypeptide binding]; other site 391595001637 GTP/Mg2+ binding site [chemical binding]; other site 391595001638 Switch I region; other site 391595001639 G2 box; other site 391595001640 G3 box; other site 391595001641 Switch II region; other site 391595001642 G4 box; other site 391595001643 G5 box; other site 391595001644 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 391595001645 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 391595001646 Antibiotic Binding Site [chemical binding]; other site 391595001647 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 391595001648 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 391595001649 active site 391595001650 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 391595001651 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 391595001652 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391595001653 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391595001654 ABC-ATPase subunit interface; other site 391595001655 dimer interface [polypeptide binding]; other site 391595001656 putative PBP binding regions; other site 391595001657 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 391595001658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595001659 Walker A/P-loop; other site 391595001660 ATP binding site [chemical binding]; other site 391595001661 Q-loop/lid; other site 391595001662 ABC transporter signature motif; other site 391595001663 Walker B; other site 391595001664 D-loop; other site 391595001665 H-loop/switch region; other site 391595001666 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 391595001667 metal binding site 2 [ion binding]; metal-binding site 391595001668 putative DNA binding helix; other site 391595001669 metal binding site 1 [ion binding]; metal-binding site 391595001670 dimer interface [polypeptide binding]; other site 391595001671 structural Zn2+ binding site [ion binding]; other site 391595001672 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391595001673 intersubunit interface [polypeptide binding]; other site 391595001674 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 391595001675 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 391595001676 metal binding site [ion binding]; metal-binding site 391595001677 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 391595001678 active site 391595001679 catalytic triad [active] 391595001680 RNA polymerase sigma factor; Provisional; Region: PRK12515 391595001681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391595001682 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391595001683 DNA binding residues [nucleotide binding] 391595001684 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595001685 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391595001686 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595001687 DNA-binding site [nucleotide binding]; DNA binding site 391595001688 FCD domain; Region: FCD; pfam07729 391595001689 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391595001690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595001691 NAD(P) binding site [chemical binding]; other site 391595001692 active site 391595001693 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 391595001694 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391595001695 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 391595001696 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 391595001697 DctM-like transporters; Region: DctM; pfam06808 391595001698 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391595001699 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 391595001700 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 391595001701 dimer interface [polypeptide binding]; other site 391595001702 active site 391595001703 glycine-pyridoxal phosphate binding site [chemical binding]; other site 391595001704 folate binding site [chemical binding]; other site 391595001705 ATP-NAD kinase; Region: NAD_kinase; pfam01513 391595001706 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 391595001707 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 391595001708 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 391595001709 CsbD-like; Region: CsbD; cl17424 391595001710 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 391595001711 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391595001712 acyl-activating enzyme (AAE) consensus motif; other site 391595001713 AMP binding site [chemical binding]; other site 391595001714 active site 391595001715 CoA binding site [chemical binding]; other site 391595001716 malic enzyme; Reviewed; Region: PRK12862 391595001717 Malic enzyme, N-terminal domain; Region: malic; pfam00390 391595001718 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 391595001719 putative NAD(P) binding site [chemical binding]; other site 391595001720 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 391595001721 Cupin domain; Region: Cupin_2; cl17218 391595001722 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 391595001723 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 391595001724 active site 391595001725 catalytic motif [active] 391595001726 Zn binding site [ion binding]; other site 391595001727 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 391595001728 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391595001729 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 391595001730 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 391595001731 phosphopentomutase; Provisional; Region: PRK05362 391595001732 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 391595001733 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391595001734 active site 391595001735 acyl-CoA synthetase; Validated; Region: PRK08162 391595001736 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 391595001737 acyl-activating enzyme (AAE) consensus motif; other site 391595001738 putative active site [active] 391595001739 AMP binding site [chemical binding]; other site 391595001740 putative CoA binding site [chemical binding]; other site 391595001741 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 391595001742 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 391595001743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391595001744 substrate binding site [chemical binding]; other site 391595001745 oxyanion hole (OAH) forming residues; other site 391595001746 trimer interface [polypeptide binding]; other site 391595001747 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391595001748 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391595001749 Cupin domain; Region: Cupin_2; cl17218 391595001750 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 391595001751 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391595001752 dimer interface [polypeptide binding]; other site 391595001753 active site 391595001754 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391595001755 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 391595001756 putative C-terminal domain interface [polypeptide binding]; other site 391595001757 putative GSH binding site (G-site) [chemical binding]; other site 391595001758 putative dimer interface [polypeptide binding]; other site 391595001759 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391595001760 N-terminal domain interface [polypeptide binding]; other site 391595001761 dimer interface [polypeptide binding]; other site 391595001762 substrate binding pocket (H-site) [chemical binding]; other site 391595001763 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391595001764 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391595001765 active site 391595001766 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 391595001767 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 391595001768 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391595001769 active site 391595001770 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 391595001771 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 391595001772 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391595001773 DNA binding residues [nucleotide binding] 391595001774 putative dimer interface [polypeptide binding]; other site 391595001775 Autoinducer binding domain; Region: Autoind_bind; pfam03472 391595001776 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391595001777 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391595001778 DNA binding residues [nucleotide binding] 391595001779 dimerization interface [polypeptide binding]; other site 391595001780 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 391595001781 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 391595001782 DNA binding residues [nucleotide binding] 391595001783 putative dimer interface [polypeptide binding]; other site 391595001784 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391595001785 CoenzymeA binding site [chemical binding]; other site 391595001786 subunit interaction site [polypeptide binding]; other site 391595001787 PHB binding site; other site 391595001788 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391595001789 CoenzymeA binding site [chemical binding]; other site 391595001790 subunit interaction site [polypeptide binding]; other site 391595001791 PHB binding site; other site 391595001792 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 391595001793 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 391595001794 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 391595001795 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 391595001796 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 391595001797 quinone interaction residues [chemical binding]; other site 391595001798 active site 391595001799 catalytic residues [active] 391595001800 FMN binding site [chemical binding]; other site 391595001801 substrate binding site [chemical binding]; other site 391595001802 Protein of unknown function (DUF952); Region: DUF952; pfam06108 391595001803 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 391595001804 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 391595001805 active site 391595001806 metal binding site [ion binding]; metal-binding site 391595001807 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 391595001808 Uncharacterized conserved protein [Function unknown]; Region: COG2135 391595001809 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391595001810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595001811 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595001812 dimerization interface [polypeptide binding]; other site 391595001813 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 391595001814 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391595001815 FAD binding site [chemical binding]; other site 391595001816 substrate binding pocket [chemical binding]; other site 391595001817 catalytic base [active] 391595001818 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391595001819 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391595001820 Walker A/P-loop; other site 391595001821 ATP binding site [chemical binding]; other site 391595001822 Q-loop/lid; other site 391595001823 ABC transporter signature motif; other site 391595001824 Walker B; other site 391595001825 D-loop; other site 391595001826 H-loop/switch region; other site 391595001827 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595001828 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391595001829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595001830 dimer interface [polypeptide binding]; other site 391595001831 conserved gate region; other site 391595001832 ABC-ATPase subunit interface; other site 391595001833 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595001834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595001835 dimer interface [polypeptide binding]; other site 391595001836 conserved gate region; other site 391595001837 putative PBP binding loops; other site 391595001838 ABC-ATPase subunit interface; other site 391595001839 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391595001840 histidinol dehydrogenase; Region: hisD; TIGR00069 391595001841 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391595001842 NAD binding site [chemical binding]; other site 391595001843 dimerization interface [polypeptide binding]; other site 391595001844 product binding site; other site 391595001845 substrate binding site [chemical binding]; other site 391595001846 zinc binding site [ion binding]; other site 391595001847 catalytic residues [active] 391595001848 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391595001849 SnoaL-like domain; Region: SnoaL_2; pfam12680 391595001850 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391595001851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595001852 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391595001853 NAD(P) binding site [chemical binding]; other site 391595001854 active site 391595001855 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391595001856 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391595001857 DNA binding site [nucleotide binding] 391595001858 domain linker motif; other site 391595001859 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 391595001860 putative dimerization interface [polypeptide binding]; other site 391595001861 putative ligand binding site [chemical binding]; other site 391595001862 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391595001863 SnoaL-like domain; Region: SnoaL_2; pfam12680 391595001864 Cupin domain; Region: Cupin_2; pfam07883 391595001865 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 391595001866 substrate binding site [chemical binding]; other site 391595001867 THF binding site; other site 391595001868 zinc-binding site [ion binding]; other site 391595001869 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391595001870 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391595001871 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391595001872 active site pocket [active] 391595001873 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 391595001874 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 391595001875 NAD binding site [chemical binding]; other site 391595001876 catalytic Zn binding site [ion binding]; other site 391595001877 substrate binding site [chemical binding]; other site 391595001878 structural Zn binding site [ion binding]; other site 391595001879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595001880 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391595001881 putative substrate translocation pore; other site 391595001882 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 391595001883 tetramer interface [polypeptide binding]; other site 391595001884 active site 391595001885 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391595001886 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 391595001887 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 391595001888 serine racemase; Region: PLN02970 391595001889 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391595001890 tetramer interface [polypeptide binding]; other site 391595001891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595001892 catalytic residue [active] 391595001893 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391595001894 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 391595001895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595001896 motif II; other site 391595001897 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 391595001898 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 391595001899 Transmembrane Fragile-X-F protein; Region: Tmemb_185A; pfam10269 391595001900 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 391595001901 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 391595001902 NAD binding site [chemical binding]; other site 391595001903 homotetramer interface [polypeptide binding]; other site 391595001904 homodimer interface [polypeptide binding]; other site 391595001905 substrate binding site [chemical binding]; other site 391595001906 active site 391595001907 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 391595001908 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391595001909 dimer interface [polypeptide binding]; other site 391595001910 active site 391595001911 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 391595001912 active site 1 [active] 391595001913 dimer interface [polypeptide binding]; other site 391595001914 active site 2 [active] 391595001915 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391595001916 metal binding site 2 [ion binding]; metal-binding site 391595001917 putative DNA binding helix; other site 391595001918 metal binding site 1 [ion binding]; metal-binding site 391595001919 dimer interface [polypeptide binding]; other site 391595001920 structural Zn2+ binding site [ion binding]; other site 391595001921 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 391595001922 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391595001923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595001924 FeS/SAM binding site; other site 391595001925 TRAM domain; Region: TRAM; pfam01938 391595001926 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 391595001927 PhoH-like protein; Region: PhoH; pfam02562 391595001928 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 391595001929 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 391595001930 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391595001931 Transporter associated domain; Region: CorC_HlyC; smart01091 391595001932 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 391595001933 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 391595001934 putative active site [active] 391595001935 catalytic triad [active] 391595001936 putative dimer interface [polypeptide binding]; other site 391595001937 S-adenosylmethionine synthetase; Validated; Region: PRK05250 391595001938 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 391595001939 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 391595001940 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 391595001941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595001942 S-adenosylmethionine binding site [chemical binding]; other site 391595001943 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 391595001944 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 391595001945 hinge; other site 391595001946 active site 391595001947 cytidylate kinase; Provisional; Region: cmk; PRK00023 391595001948 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 391595001949 CMP-binding site; other site 391595001950 The sites determining sugar specificity; other site 391595001951 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 391595001952 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 391595001953 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 391595001954 RNA binding site [nucleotide binding]; other site 391595001955 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 391595001956 RNA binding site [nucleotide binding]; other site 391595001957 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 391595001958 RNA binding site [nucleotide binding]; other site 391595001959 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391595001960 RNA binding site [nucleotide binding]; other site 391595001961 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 391595001962 RNA binding site [nucleotide binding]; other site 391595001963 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 391595001964 RNA binding site [nucleotide binding]; other site 391595001965 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391595001966 IHF dimer interface [polypeptide binding]; other site 391595001967 IHF - DNA interface [nucleotide binding]; other site 391595001968 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 391595001969 active site 391595001970 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 391595001971 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 391595001972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595001973 catalytic residue [active] 391595001974 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 391595001975 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 391595001976 Beta-lactamase; Region: Beta-lactamase; pfam00144 391595001977 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 391595001978 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 391595001979 putative active site [active] 391595001980 catalytic residue [active] 391595001981 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 391595001982 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 391595001983 5S rRNA interface [nucleotide binding]; other site 391595001984 CTC domain interface [polypeptide binding]; other site 391595001985 L16 interface [polypeptide binding]; other site 391595001986 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391595001987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595001988 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391595001989 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 391595001990 phosphate binding site [ion binding]; other site 391595001991 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 391595001992 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 391595001993 substrate binding site [chemical binding]; other site 391595001994 active site 391595001995 catalytic residues [active] 391595001996 heterodimer interface [polypeptide binding]; other site 391595001997 GTP-binding protein YchF; Reviewed; Region: PRK09601 391595001998 YchF GTPase; Region: YchF; cd01900 391595001999 G1 box; other site 391595002000 GTP/Mg2+ binding site [chemical binding]; other site 391595002001 Switch I region; other site 391595002002 G2 box; other site 391595002003 Switch II region; other site 391595002004 G3 box; other site 391595002005 G4 box; other site 391595002006 G5 box; other site 391595002007 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 391595002008 aspartate aminotransferase; Provisional; Region: PRK05764 391595002009 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391595002010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595002011 homodimer interface [polypeptide binding]; other site 391595002012 catalytic residue [active] 391595002013 transcriptional repressor DicA; Reviewed; Region: PRK09706 391595002014 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595002015 non-specific DNA binding site [nucleotide binding]; other site 391595002016 salt bridge; other site 391595002017 sequence-specific DNA binding site [nucleotide binding]; other site 391595002018 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 391595002019 allophanate hydrolase; Provisional; Region: PRK08186 391595002020 allophanate hydrolase; Provisional; Region: PRK08186 391595002021 Amidase; Region: Amidase; cl11426 391595002022 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 391595002023 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 391595002024 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391595002025 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 391595002026 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391595002027 Walker A/P-loop; other site 391595002028 ATP binding site [chemical binding]; other site 391595002029 Q-loop/lid; other site 391595002030 ABC transporter signature motif; other site 391595002031 Walker B; other site 391595002032 D-loop; other site 391595002033 H-loop/switch region; other site 391595002034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002035 dimer interface [polypeptide binding]; other site 391595002036 conserved gate region; other site 391595002037 putative PBP binding loops; other site 391595002038 ABC-ATPase subunit interface; other site 391595002039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002040 dimer interface [polypeptide binding]; other site 391595002041 conserved gate region; other site 391595002042 ABC-ATPase subunit interface; other site 391595002043 dihydroxyacetone kinase; Provisional; Region: PRK14479 391595002044 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 391595002045 DAK2 domain; Region: Dak2; cl03685 391595002046 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 391595002047 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391595002048 DNA binding site [nucleotide binding] 391595002049 domain linker motif; other site 391595002050 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 391595002051 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391595002052 putative ligand binding site [chemical binding]; other site 391595002053 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391595002054 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 391595002055 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595002056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595002057 Walker A/P-loop; other site 391595002058 ATP binding site [chemical binding]; other site 391595002059 Q-loop/lid; other site 391595002060 ABC transporter signature motif; other site 391595002061 Walker B; other site 391595002062 D-loop; other site 391595002063 H-loop/switch region; other site 391595002064 TOBE domain; Region: TOBE_2; pfam08402 391595002065 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595002066 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391595002067 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 391595002068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002069 dimer interface [polypeptide binding]; other site 391595002070 conserved gate region; other site 391595002071 putative PBP binding loops; other site 391595002072 ABC-ATPase subunit interface; other site 391595002073 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595002074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002075 dimer interface [polypeptide binding]; other site 391595002076 conserved gate region; other site 391595002077 putative PBP binding loops; other site 391595002078 ABC-ATPase subunit interface; other site 391595002079 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595002080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595002081 Walker A/P-loop; other site 391595002082 ATP binding site [chemical binding]; other site 391595002083 Q-loop/lid; other site 391595002084 ABC transporter signature motif; other site 391595002085 Walker B; other site 391595002086 D-loop; other site 391595002087 H-loop/switch region; other site 391595002088 TOBE domain; Region: TOBE_2; pfam08402 391595002089 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391595002090 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391595002091 substrate binding site [chemical binding]; other site 391595002092 ATP binding site [chemical binding]; other site 391595002093 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 391595002094 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595002095 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595002096 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391595002097 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 391595002098 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391595002099 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 391595002100 Metal-binding active site; metal-binding site 391595002101 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391595002102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595002103 NAD(P) binding site [chemical binding]; other site 391595002104 active site 391595002105 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391595002106 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 391595002107 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 391595002108 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 391595002109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595002110 Cupin domain; Region: Cupin_2; cl17218 391595002111 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595002112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595002113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595002114 dimerization interface [polypeptide binding]; other site 391595002115 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391595002116 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595002117 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391595002118 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391595002119 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595002120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595002121 Walker A/P-loop; other site 391595002122 ATP binding site [chemical binding]; other site 391595002123 Q-loop/lid; other site 391595002124 ABC transporter signature motif; other site 391595002125 Walker B; other site 391595002126 D-loop; other site 391595002127 H-loop/switch region; other site 391595002128 TOBE domain; Region: TOBE_2; pfam08402 391595002129 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 391595002130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002131 dimer interface [polypeptide binding]; other site 391595002132 conserved gate region; other site 391595002133 putative PBP binding loops; other site 391595002134 ABC-ATPase subunit interface; other site 391595002135 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595002136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002137 dimer interface [polypeptide binding]; other site 391595002138 conserved gate region; other site 391595002139 putative PBP binding loops; other site 391595002140 ABC-ATPase subunit interface; other site 391595002141 choline dehydrogenase; Validated; Region: PRK02106 391595002142 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391595002143 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391595002144 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391595002145 active site pocket [active] 391595002146 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 391595002147 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391595002148 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595002149 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 391595002150 heme-binding site [chemical binding]; other site 391595002151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391595002152 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391595002153 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391595002154 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 391595002155 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 391595002156 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 391595002157 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391595002158 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391595002159 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 391595002160 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 391595002161 active site 391595002162 FMN binding site [chemical binding]; other site 391595002163 substrate binding site [chemical binding]; other site 391595002164 3Fe-4S cluster binding site [ion binding]; other site 391595002165 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 391595002166 domain_subunit interface; other site 391595002167 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 391595002168 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 391595002169 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 391595002170 putative active site [active] 391595002171 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 391595002172 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391595002173 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595002174 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 391595002175 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391595002176 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 391595002177 FMN-binding pocket [chemical binding]; other site 391595002178 flavin binding motif; other site 391595002179 phosphate binding motif [ion binding]; other site 391595002180 beta-alpha-beta structure motif; other site 391595002181 NAD binding pocket [chemical binding]; other site 391595002182 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391595002183 catalytic loop [active] 391595002184 iron binding site [ion binding]; other site 391595002185 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 391595002186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595002187 non-specific DNA binding site [nucleotide binding]; other site 391595002188 salt bridge; other site 391595002189 sequence-specific DNA binding site [nucleotide binding]; other site 391595002190 Cupin domain; Region: Cupin_2; pfam07883 391595002191 Bacterial sugar transferase; Region: Bac_transf; pfam02397 391595002192 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391595002193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595002194 Walker A/P-loop; other site 391595002195 ATP binding site [chemical binding]; other site 391595002196 Q-loop/lid; other site 391595002197 ABC transporter signature motif; other site 391595002198 Walker B; other site 391595002199 D-loop; other site 391595002200 H-loop/switch region; other site 391595002201 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 391595002202 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 391595002203 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 391595002204 Ligand Binding Site [chemical binding]; other site 391595002205 Molecular Tunnel; other site 391595002206 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 391595002207 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 391595002208 active site 391595002209 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391595002210 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391595002211 Right handed beta helix region; Region: Beta_helix; pfam13229 391595002212 Right handed beta helix region; Region: Beta_helix; pfam13229 391595002213 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 391595002214 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 391595002215 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 391595002216 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 391595002217 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 391595002218 hypothetical protein; Provisional; Region: PRK01184 391595002219 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 391595002220 Chain length determinant protein; Region: Wzz; cl15801 391595002221 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 391595002222 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 391595002223 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 391595002224 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391595002225 putative catalytic site [active] 391595002226 putative metal binding site [ion binding]; other site 391595002227 putative phosphate binding site [ion binding]; other site 391595002228 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 391595002229 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 391595002230 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 391595002231 putative active site [active] 391595002232 catalytic site [active] 391595002233 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 391595002234 putative active site [active] 391595002235 catalytic site [active] 391595002236 Acetokinase family; Region: Acetate_kinase; cl17229 391595002237 propionate/acetate kinase; Provisional; Region: PRK12379 391595002238 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 391595002239 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 391595002240 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 391595002241 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 391595002242 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 391595002243 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 391595002244 precorrin-3B synthase; Region: CobG; TIGR02435 391595002245 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391595002246 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 391595002247 Precorrin-8X methylmutase; Region: CbiC; pfam02570 391595002248 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 391595002249 active site 391595002250 SAM binding site [chemical binding]; other site 391595002251 homodimer interface [polypeptide binding]; other site 391595002252 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 391595002253 active site 391595002254 SAM binding site [chemical binding]; other site 391595002255 homodimer interface [polypeptide binding]; other site 391595002256 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 391595002257 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 391595002258 active site 391595002259 putative homodimer interface [polypeptide binding]; other site 391595002260 SAM binding site [chemical binding]; other site 391595002261 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 391595002262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595002263 S-adenosylmethionine binding site [chemical binding]; other site 391595002264 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 391595002265 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 391595002266 active site 391595002267 SAM binding site [chemical binding]; other site 391595002268 homodimer interface [polypeptide binding]; other site 391595002269 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 391595002270 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 391595002271 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 391595002272 active site 391595002273 SAM binding site [chemical binding]; other site 391595002274 homodimer interface [polypeptide binding]; other site 391595002275 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 391595002276 active site 391595002277 SAM binding site [chemical binding]; other site 391595002278 homodimer interface [polypeptide binding]; other site 391595002279 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 391595002280 putative FMN binding site [chemical binding]; other site 391595002281 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 391595002282 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391595002283 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 391595002284 phosphate binding site [ion binding]; other site 391595002285 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 391595002286 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 391595002287 TPP-binding site; other site 391595002288 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391595002289 PYR/PP interface [polypeptide binding]; other site 391595002290 dimer interface [polypeptide binding]; other site 391595002291 TPP binding site [chemical binding]; other site 391595002292 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391595002293 Ligand Binding Site [chemical binding]; other site 391595002294 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 391595002295 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391595002296 NAD(P) binding site [chemical binding]; other site 391595002297 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 391595002298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595002299 NAD(P) binding site [chemical binding]; other site 391595002300 active site 391595002301 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391595002302 histidinol dehydrogenase; Region: hisD; TIGR00069 391595002303 NAD binding site [chemical binding]; other site 391595002304 dimerization interface [polypeptide binding]; other site 391595002305 product binding site; other site 391595002306 substrate binding site [chemical binding]; other site 391595002307 zinc binding site [ion binding]; other site 391595002308 catalytic residues [active] 391595002309 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391595002310 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391595002311 DNA binding site [nucleotide binding] 391595002312 domain linker motif; other site 391595002313 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 391595002314 putative dimerization interface [polypeptide binding]; other site 391595002315 putative ligand binding site [chemical binding]; other site 391595002316 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 391595002317 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 391595002318 substrate binding site [chemical binding]; other site 391595002319 catalytic Zn binding site [ion binding]; other site 391595002320 NAD binding site [chemical binding]; other site 391595002321 structural Zn binding site [ion binding]; other site 391595002322 dimer interface [polypeptide binding]; other site 391595002323 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391595002324 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 391595002325 UreF; Region: UreF; pfam01730 391595002326 urease accessory protein UreE; Provisional; Region: PRK14113 391595002327 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 391595002328 dimer interface [polypeptide binding]; other site 391595002329 catalytic residues [active] 391595002330 urease subunit alpha; Reviewed; Region: ureC; PRK13207 391595002331 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 391595002332 subunit interactions [polypeptide binding]; other site 391595002333 active site 391595002334 flap region; other site 391595002335 Uncharacterized conserved protein [Function unknown]; Region: COG2128 391595002336 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 391595002337 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 391595002338 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 391595002339 gamma-beta subunit interface [polypeptide binding]; other site 391595002340 alpha-beta subunit interface [polypeptide binding]; other site 391595002341 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 391595002342 alpha-gamma subunit interface [polypeptide binding]; other site 391595002343 beta-gamma subunit interface [polypeptide binding]; other site 391595002344 UreD urease accessory protein; Region: UreD; pfam01774 391595002345 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391595002346 Uncharacterized conserved protein [Function unknown]; Region: COG1359 391595002347 tartrate dehydrogenase; Region: TTC; TIGR02089 391595002348 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 391595002349 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595002350 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595002351 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391595002352 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391595002353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595002354 DNA-binding site [nucleotide binding]; DNA binding site 391595002355 FCD domain; Region: FCD; pfam07729 391595002356 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391595002357 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391595002358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 391595002359 putative aldolase; Validated; Region: PRK08130 391595002360 intersubunit interface [polypeptide binding]; other site 391595002361 active site 391595002362 Zn2+ binding site [ion binding]; other site 391595002363 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 391595002364 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391595002365 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391595002366 conserved cys residue [active] 391595002367 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595002368 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391595002369 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391595002370 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 391595002371 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595002372 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 391595002373 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 391595002374 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391595002375 Predicted aconitase [General function prediction only]; Region: COG1679 391595002376 Protein of unknown function (DUF521); Region: DUF521; pfam04412 391595002377 Protein of unknown function DUF126; Region: DUF126; pfam01989 391595002378 substrate binding site [chemical binding]; other site 391595002379 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 391595002380 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 391595002381 substrate-cofactor binding pocket; other site 391595002382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595002383 catalytic residue [active] 391595002384 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391595002385 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391595002386 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 391595002387 putative N-terminal domain interface [polypeptide binding]; other site 391595002388 putative dimer interface [polypeptide binding]; other site 391595002389 putative substrate binding pocket (H-site) [chemical binding]; other site 391595002390 Glucokinase; Region: Glucokinase; pfam02685 391595002391 glucokinase, proteobacterial type; Region: glk; TIGR00749 391595002392 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 391595002393 heterodimer interface [polypeptide binding]; other site 391595002394 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 391595002395 active site 391595002396 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 391595002397 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 391595002398 active site 391595002399 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 391595002400 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 391595002401 DctM-like transporters; Region: DctM; pfam06808 391595002402 TM2 domain; Region: TM2; pfam05154 391595002403 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391595002404 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595002405 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391595002406 Ligand Binding Site [chemical binding]; other site 391595002407 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 391595002408 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 391595002409 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391595002410 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 391595002411 substrate binding site [chemical binding]; other site 391595002412 ATP binding site [chemical binding]; other site 391595002413 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 391595002414 Amidohydrolase; Region: Amidohydro_2; pfam04909 391595002415 active site 391595002416 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391595002417 active site 391595002418 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391595002419 catalytic tetrad [active] 391595002420 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 391595002421 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 391595002422 N- and C-terminal domain interface [polypeptide binding]; other site 391595002423 putative active site [active] 391595002424 MgATP binding site [chemical binding]; other site 391595002425 catalytic site [active] 391595002426 metal binding site [ion binding]; metal-binding site 391595002427 putative xylulose binding site [chemical binding]; other site 391595002428 putative homodimer interface [polypeptide binding]; other site 391595002429 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595002430 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595002431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391595002432 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391595002433 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391595002434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 391595002435 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391595002436 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391595002437 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595002438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002439 dimer interface [polypeptide binding]; other site 391595002440 conserved gate region; other site 391595002441 ABC-ATPase subunit interface; other site 391595002442 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595002443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002444 dimer interface [polypeptide binding]; other site 391595002445 conserved gate region; other site 391595002446 putative PBP binding loops; other site 391595002447 ABC-ATPase subunit interface; other site 391595002448 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595002449 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391595002450 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391595002451 Walker A/P-loop; other site 391595002452 ATP binding site [chemical binding]; other site 391595002453 Q-loop/lid; other site 391595002454 ABC transporter signature motif; other site 391595002455 Walker B; other site 391595002456 D-loop; other site 391595002457 H-loop/switch region; other site 391595002458 TOBE domain; Region: TOBE_2; pfam08402 391595002459 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 391595002460 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391595002461 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 391595002462 substrate binding site [chemical binding]; other site 391595002463 dimer interface [polypeptide binding]; other site 391595002464 ATP binding site [chemical binding]; other site 391595002465 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 391595002466 ligand binding site [chemical binding]; other site 391595002467 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 391595002468 putative active site [active] 391595002469 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391595002470 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391595002471 SdiA-regulated; Region: SdiA-regulated; cd09971 391595002472 putative active site [active] 391595002473 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 391595002474 ABC1 family; Region: ABC1; pfam03109 391595002475 serine/threonine protein kinase; Provisional; Region: PRK14879 391595002476 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 391595002477 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391595002478 HlyD family secretion protein; Region: HlyD_3; pfam13437 391595002479 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 391595002480 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595002481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595002482 Walker A/P-loop; other site 391595002483 ATP binding site [chemical binding]; other site 391595002484 Q-loop/lid; other site 391595002485 ABC transporter signature motif; other site 391595002486 Walker B; other site 391595002487 D-loop; other site 391595002488 H-loop/switch region; other site 391595002489 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 391595002490 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595002491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595002492 Walker A/P-loop; other site 391595002493 ATP binding site [chemical binding]; other site 391595002494 Q-loop/lid; other site 391595002495 Walker B; other site 391595002496 D-loop; other site 391595002497 H-loop/switch region; other site 391595002498 PA14 domain; Region: PA14; cl08459 391595002499 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 391595002500 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391595002501 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391595002502 DNA binding site [nucleotide binding] 391595002503 domain linker motif; other site 391595002504 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 391595002505 putative dimerization interface [polypeptide binding]; other site 391595002506 putative ligand binding site [chemical binding]; other site 391595002507 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595002508 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391595002509 Walker A/P-loop; other site 391595002510 ATP binding site [chemical binding]; other site 391595002511 Q-loop/lid; other site 391595002512 ABC transporter signature motif; other site 391595002513 Walker B; other site 391595002514 D-loop; other site 391595002515 H-loop/switch region; other site 391595002516 TOBE domain; Region: TOBE_2; pfam08402 391595002517 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595002518 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391595002519 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391595002520 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 391595002521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002522 dimer interface [polypeptide binding]; other site 391595002523 conserved gate region; other site 391595002524 putative PBP binding loops; other site 391595002525 ABC-ATPase subunit interface; other site 391595002526 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595002527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002528 dimer interface [polypeptide binding]; other site 391595002529 conserved gate region; other site 391595002530 putative PBP binding loops; other site 391595002531 ABC-ATPase subunit interface; other site 391595002532 Eukaryotic cytochrome b(561), including the FRRS1 gene product; Region: Cyt_b561_FRRS1_like; cd08760 391595002533 putative heme binding sites [chemical binding]; other site 391595002534 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 391595002535 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 391595002536 active site 391595002537 homodimer interface [polypeptide binding]; other site 391595002538 catalytic site [active] 391595002539 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 391595002540 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 391595002541 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595002542 active site 391595002543 motif I; other site 391595002544 motif II; other site 391595002545 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 391595002546 SnoaL-like domain; Region: SnoaL_4; pfam13577 391595002547 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 391595002548 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 391595002549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595002550 Walker A motif; other site 391595002551 ATP binding site [chemical binding]; other site 391595002552 Walker B motif; other site 391595002553 arginine finger; other site 391595002554 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391595002555 SnoaL-like domain; Region: SnoaL_2; pfam12680 391595002556 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 391595002557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 391595002558 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391595002559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595002560 DNA-binding site [nucleotide binding]; DNA binding site 391595002561 FCD domain; Region: FCD; pfam07729 391595002562 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391595002563 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595002564 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391595002565 DctM-like transporters; Region: DctM; pfam06808 391595002566 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391595002567 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 391595002568 malonyl-CoA synthase; Validated; Region: PRK07514 391595002569 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 391595002570 acyl-activating enzyme (AAE) consensus motif; other site 391595002571 active site 391595002572 AMP binding site [chemical binding]; other site 391595002573 CoA binding site [chemical binding]; other site 391595002574 xylose isomerase; Provisional; Region: PRK05474 391595002575 xylose isomerase; Region: xylose_isom_A; TIGR02630 391595002576 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 391595002577 N- and C-terminal domain interface [polypeptide binding]; other site 391595002578 D-xylulose kinase; Region: XylB; TIGR01312 391595002579 active site 391595002580 MgATP binding site [chemical binding]; other site 391595002581 catalytic site [active] 391595002582 metal binding site [ion binding]; metal-binding site 391595002583 xylulose binding site [chemical binding]; other site 391595002584 homodimer interface [polypeptide binding]; other site 391595002585 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595002586 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595002587 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391595002588 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391595002589 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 391595002590 Metal-binding active site; metal-binding site 391595002591 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 391595002592 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 391595002593 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 391595002594 DAK2 domain; Region: Dak2; pfam02734 391595002595 PAS domain; Region: PAS_9; pfam13426 391595002596 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 391595002597 putative active site [active] 391595002598 heme pocket [chemical binding]; other site 391595002599 PAS fold; Region: PAS_7; pfam12860 391595002600 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391595002601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391595002602 metal binding site [ion binding]; metal-binding site 391595002603 active site 391595002604 I-site; other site 391595002605 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391595002606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595002607 S-adenosylmethionine binding site [chemical binding]; other site 391595002608 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 391595002609 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595002610 ligand binding site [chemical binding]; other site 391595002611 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391595002612 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391595002613 Walker A/P-loop; other site 391595002614 ATP binding site [chemical binding]; other site 391595002615 Q-loop/lid; other site 391595002616 ABC transporter signature motif; other site 391595002617 Walker B; other site 391595002618 D-loop; other site 391595002619 H-loop/switch region; other site 391595002620 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391595002621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002622 dimer interface [polypeptide binding]; other site 391595002623 conserved gate region; other site 391595002624 putative PBP binding loops; other site 391595002625 ABC-ATPase subunit interface; other site 391595002626 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391595002627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002628 dimer interface [polypeptide binding]; other site 391595002629 conserved gate region; other site 391595002630 putative PBP binding loops; other site 391595002631 ABC-ATPase subunit interface; other site 391595002632 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391595002633 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391595002634 substrate binding pocket [chemical binding]; other site 391595002635 membrane-bound complex binding site; other site 391595002636 hinge residues; other site 391595002637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595002638 cell density-dependent motility repressor; Provisional; Region: PRK10082 391595002639 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391595002640 dimerization interface [polypeptide binding]; other site 391595002641 D-cysteine desulfhydrase; Validated; Region: PRK03910 391595002642 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 391595002643 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595002644 catalytic residue [active] 391595002645 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391595002646 aspartate racemase; Region: asp_race; TIGR00035 391595002647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595002648 heat shock protein 90; Provisional; Region: PRK05218 391595002649 ATP binding site [chemical binding]; other site 391595002650 Mg2+ binding site [ion binding]; other site 391595002651 G-X-G motif; other site 391595002652 hypothetical protein; Provisional; Region: PRK07079 391595002653 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 391595002654 metal binding site [ion binding]; metal-binding site 391595002655 putative dimer interface [polypeptide binding]; other site 391595002656 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 391595002657 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 391595002658 hypothetical protein; Reviewed; Region: PRK00024 391595002659 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 391595002660 MPN+ (JAMM) motif; other site 391595002661 Zinc-binding site [ion binding]; other site 391595002662 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 391595002663 Cytochrome c553 [Energy production and conversion]; Region: COG2863 391595002664 Cytochrome c; Region: Cytochrom_C; cl11414 391595002665 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 391595002666 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 391595002667 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 391595002668 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391595002669 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391595002670 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 391595002671 DctM-like transporters; Region: DctM; pfam06808 391595002672 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391595002673 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391595002674 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595002675 Isochorismatase family; Region: Isochorismatase; pfam00857 391595002676 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 391595002677 catalytic triad [active] 391595002678 conserved cis-peptide bond; other site 391595002679 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 391595002680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595002681 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 391595002682 dimerization interface [polypeptide binding]; other site 391595002683 substrate binding pocket [chemical binding]; other site 391595002684 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595002685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595002686 Walker A/P-loop; other site 391595002687 ATP binding site [chemical binding]; other site 391595002688 Q-loop/lid; other site 391595002689 ABC transporter signature motif; other site 391595002690 Walker B; other site 391595002691 D-loop; other site 391595002692 H-loop/switch region; other site 391595002693 TOBE domain; Region: TOBE_2; pfam08402 391595002694 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595002695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391595002696 ABC-ATPase subunit interface; other site 391595002697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002698 dimer interface [polypeptide binding]; other site 391595002699 conserved gate region; other site 391595002700 putative PBP binding loops; other site 391595002701 ABC-ATPase subunit interface; other site 391595002702 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391595002703 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391595002704 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 391595002705 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 391595002706 dimer interface [polypeptide binding]; other site 391595002707 active site 391595002708 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391595002709 substrate binding site [chemical binding]; other site 391595002710 catalytic residue [active] 391595002711 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 391595002712 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391595002713 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 391595002714 iron-sulfur cluster [ion binding]; other site 391595002715 [2Fe-2S] cluster binding site [ion binding]; other site 391595002716 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 391595002717 alpha subunit interface [polypeptide binding]; other site 391595002718 active site 391595002719 substrate binding site [chemical binding]; other site 391595002720 Fe binding site [ion binding]; other site 391595002721 urocanate hydratase; Provisional; Region: PRK05414 391595002722 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391595002723 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391595002724 active site 391595002725 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391595002726 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391595002727 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391595002728 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 391595002729 active sites [active] 391595002730 tetramer interface [polypeptide binding]; other site 391595002731 imidazolonepropionase; Validated; Region: PRK09356 391595002732 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 391595002733 active site 391595002734 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 391595002735 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595002736 active site 391595002737 hypothetical protein; Provisional; Region: PRK06148 391595002738 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 391595002739 active site 391595002740 ATP binding site [chemical binding]; other site 391595002741 substrate binding site [chemical binding]; other site 391595002742 Peptidase family M23; Region: Peptidase_M23; pfam01551 391595002743 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391595002744 inhibitor-cofactor binding pocket; inhibition site 391595002745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595002746 catalytic residue [active] 391595002747 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 391595002748 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 391595002749 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595002750 catalytic residue [active] 391595002751 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391595002752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595002753 DNA-binding site [nucleotide binding]; DNA binding site 391595002754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391595002755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595002756 homodimer interface [polypeptide binding]; other site 391595002757 catalytic residue [active] 391595002758 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391595002759 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 391595002760 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 391595002761 DctM-like transporters; Region: DctM; pfam06808 391595002762 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391595002763 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391595002764 Ligand Binding Site [chemical binding]; other site 391595002765 SnoaL-like domain; Region: SnoaL_2; pfam12680 391595002766 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595002767 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391595002768 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 391595002769 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391595002770 PYR/PP interface [polypeptide binding]; other site 391595002771 dimer interface [polypeptide binding]; other site 391595002772 TPP binding site [chemical binding]; other site 391595002773 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391595002774 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391595002775 TPP-binding site [chemical binding]; other site 391595002776 Predicted membrane protein [Function unknown]; Region: COG2855 391595002777 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 391595002778 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 391595002779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595002780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595002781 Protein of unknown function, DUF417; Region: DUF417; cl01162 391595002782 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 391595002783 GSH binding site [chemical binding]; other site 391595002784 catalytic residues [active] 391595002785 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 391595002786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595002787 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391595002788 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391595002789 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 391595002790 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391595002791 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 391595002792 HAMP domain; Region: HAMP; pfam00672 391595002793 dimerization interface [polypeptide binding]; other site 391595002794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595002795 dimer interface [polypeptide binding]; other site 391595002796 phosphorylation site [posttranslational modification] 391595002797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595002798 ATP binding site [chemical binding]; other site 391595002799 Mg2+ binding site [ion binding]; other site 391595002800 G-X-G motif; other site 391595002801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595002802 active site 391595002803 phosphorylation site [posttranslational modification] 391595002804 intermolecular recognition site; other site 391595002805 dimerization interface [polypeptide binding]; other site 391595002806 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 391595002807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595002808 active site 391595002809 phosphorylation site [posttranslational modification] 391595002810 intermolecular recognition site; other site 391595002811 dimerization interface [polypeptide binding]; other site 391595002812 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391595002813 DNA binding site [nucleotide binding] 391595002814 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391595002815 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 391595002816 molybdopterin cofactor binding site; other site 391595002817 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 391595002818 molybdopterin cofactor binding site; other site 391595002819 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595002820 EamA-like transporter family; Region: EamA; cl17759 391595002821 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 391595002822 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 391595002823 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 391595002824 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 391595002825 substrate binding pocket [chemical binding]; other site 391595002826 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 391595002827 B12 binding site [chemical binding]; other site 391595002828 cobalt ligand [ion binding]; other site 391595002829 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 391595002830 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 391595002831 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 391595002832 chorismate binding enzyme; Region: Chorismate_bind; cl10555 391595002833 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 391595002834 Uncharacterized conserved protein [Function unknown]; Region: COG1262 391595002835 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 391595002836 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391595002837 MarR family; Region: MarR_2; cl17246 391595002838 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 391595002839 catalytic core [active] 391595002840 fumarylacetoacetase; Region: PLN02856 391595002841 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 391595002842 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391595002843 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 391595002844 maleylacetoacetate isomerase; Region: maiA; TIGR01262 391595002845 C-terminal domain interface [polypeptide binding]; other site 391595002846 GSH binding site (G-site) [chemical binding]; other site 391595002847 putative dimer interface [polypeptide binding]; other site 391595002848 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 391595002849 dimer interface [polypeptide binding]; other site 391595002850 N-terminal domain interface [polypeptide binding]; other site 391595002851 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 391595002852 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 391595002853 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391595002854 MarR family; Region: MarR_2; pfam12802 391595002855 MarR family; Region: MarR_2; cl17246 391595002856 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 391595002857 Coenzyme A transferase; Region: CoA_trans; smart00882 391595002858 Coenzyme A transferase; Region: CoA_trans; cl17247 391595002859 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 391595002860 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391595002861 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391595002862 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 391595002863 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391595002864 Sulfatase; Region: Sulfatase; cl17466 391595002865 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391595002866 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391595002867 kynureninase; Region: kynureninase; TIGR01814 391595002868 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595002869 catalytic residue [active] 391595002870 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595002871 L-aspartate dehydrogenase; Provisional; Region: PRK13303 391595002872 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 391595002873 Domain of unknown function DUF108; Region: DUF108; pfam01958 391595002874 AAA domain; Region: AAA_23; pfam13476 391595002875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595002876 Walker A/P-loop; other site 391595002877 ATP binding site [chemical binding]; other site 391595002878 ABC transporter; Region: ABC_tran; pfam00005 391595002879 Q-loop/lid; other site 391595002880 ABC transporter signature motif; other site 391595002881 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 391595002882 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 391595002883 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595002884 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391595002885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002886 putative PBP binding loops; other site 391595002887 dimer interface [polypeptide binding]; other site 391595002888 ABC-ATPase subunit interface; other site 391595002889 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595002890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002891 dimer interface [polypeptide binding]; other site 391595002892 conserved gate region; other site 391595002893 ABC-ATPase subunit interface; other site 391595002894 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595002895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595002896 Walker A/P-loop; other site 391595002897 ATP binding site [chemical binding]; other site 391595002898 Q-loop/lid; other site 391595002899 ABC transporter signature motif; other site 391595002900 Walker B; other site 391595002901 D-loop; other site 391595002902 H-loop/switch region; other site 391595002903 TOBE domain; Region: TOBE_2; pfam08402 391595002904 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595002905 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391595002906 Walker A/P-loop; other site 391595002907 ATP binding site [chemical binding]; other site 391595002908 Q-loop/lid; other site 391595002909 ABC transporter signature motif; other site 391595002910 Walker B; other site 391595002911 D-loop; other site 391595002912 H-loop/switch region; other site 391595002913 TOBE domain; Region: TOBE_2; pfam08402 391595002914 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 391595002915 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 391595002916 putative N- and C-terminal domain interface [polypeptide binding]; other site 391595002917 putative active site [active] 391595002918 MgATP binding site [chemical binding]; other site 391595002919 catalytic site [active] 391595002920 metal binding site [ion binding]; metal-binding site 391595002921 putative xylulose binding site [chemical binding]; other site 391595002922 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 391595002923 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391595002924 putative ligand binding site [chemical binding]; other site 391595002925 putative NAD binding site [chemical binding]; other site 391595002926 catalytic site [active] 391595002927 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 391595002928 intersubunit interface [polypeptide binding]; other site 391595002929 active site 391595002930 Zn2+ binding site [ion binding]; other site 391595002931 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 391595002932 Uncharacterized conserved protein [Function unknown]; Region: COG3347 391595002933 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 391595002934 intersubunit interface [polypeptide binding]; other site 391595002935 active site 391595002936 Zn2+ binding site [ion binding]; other site 391595002937 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391595002938 D-xylulose kinase; Region: XylB; TIGR01312 391595002939 nucleotide binding site [chemical binding]; other site 391595002940 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 391595002941 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 391595002942 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595002943 motif II; other site 391595002944 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 391595002945 triosephosphate isomerase; Provisional; Region: PRK14565 391595002946 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 391595002947 substrate binding site [chemical binding]; other site 391595002948 dimer interface [polypeptide binding]; other site 391595002949 catalytic triad [active] 391595002950 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 391595002951 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 391595002952 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 391595002953 inhibitor binding site; inhibition site 391595002954 catalytic Zn binding site [ion binding]; other site 391595002955 structural Zn binding site [ion binding]; other site 391595002956 NADP binding site [chemical binding]; other site 391595002957 tetramer interface [polypeptide binding]; other site 391595002958 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391595002959 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391595002960 Walker A/P-loop; other site 391595002961 ATP binding site [chemical binding]; other site 391595002962 Q-loop/lid; other site 391595002963 ABC transporter signature motif; other site 391595002964 Walker B; other site 391595002965 D-loop; other site 391595002966 H-loop/switch region; other site 391595002967 TOBE domain; Region: TOBE_2; pfam08402 391595002968 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391595002969 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391595002970 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595002971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002972 dimer interface [polypeptide binding]; other site 391595002973 conserved gate region; other site 391595002974 putative PBP binding loops; other site 391595002975 ABC-ATPase subunit interface; other site 391595002976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595002977 dimer interface [polypeptide binding]; other site 391595002978 conserved gate region; other site 391595002979 ABC-ATPase subunit interface; other site 391595002980 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 391595002981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595002982 active site 391595002983 motif I; other site 391595002984 motif II; other site 391595002985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595002986 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 391595002987 putative N- and C-terminal domain interface [polypeptide binding]; other site 391595002988 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 391595002989 putative active site [active] 391595002990 MgATP binding site [chemical binding]; other site 391595002991 catalytic site [active] 391595002992 metal binding site [ion binding]; metal-binding site 391595002993 putative carbohydrate binding site [chemical binding]; other site 391595002994 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 391595002995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595002996 NAD(P) binding site [chemical binding]; other site 391595002997 active site 391595002998 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 391595002999 active site 391595003000 NAD binding site [chemical binding]; other site 391595003001 metal binding site [ion binding]; metal-binding site 391595003002 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 391595003003 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391595003004 non-specific DNA interactions [nucleotide binding]; other site 391595003005 DNA binding site [nucleotide binding] 391595003006 sequence specific DNA binding site [nucleotide binding]; other site 391595003007 putative cAMP binding site [chemical binding]; other site 391595003008 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 391595003009 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 391595003010 dimer interface [polypeptide binding]; other site 391595003011 substrate binding site [chemical binding]; other site 391595003012 ATP binding site [chemical binding]; other site 391595003013 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391595003014 thiamine phosphate binding site [chemical binding]; other site 391595003015 active site 391595003016 pyrophosphate binding site [ion binding]; other site 391595003017 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 391595003018 substrate binding site [chemical binding]; other site 391595003019 multimerization interface [polypeptide binding]; other site 391595003020 ATP binding site [chemical binding]; other site 391595003021 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391595003022 classical (c) SDRs; Region: SDR_c; cd05233 391595003023 NAD(P) binding site [chemical binding]; other site 391595003024 active site 391595003025 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595003026 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 391595003027 DctM-like transporters; Region: DctM; pfam06808 391595003028 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391595003029 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 391595003030 putative metal binding residues [ion binding]; other site 391595003031 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391595003032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391595003033 DNA binding site [nucleotide binding] 391595003034 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 391595003035 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 391595003036 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391595003037 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 391595003038 active site 391595003039 nucleotide binding site [chemical binding]; other site 391595003040 HIGH motif; other site 391595003041 KMSKS motif; other site 391595003042 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 391595003043 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 391595003044 active site 391595003045 metal-binding site 391595003046 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 391595003047 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 391595003048 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391595003049 Uncharacterized conserved protein [Function unknown]; Region: COG1359 391595003050 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391595003051 MarR family; Region: MarR_2; pfam12802 391595003052 Helix-turn-helix domain; Region: HTH_18; pfam12833 391595003053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595003054 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 391595003055 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 391595003056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595003057 S-adenosylmethionine binding site [chemical binding]; other site 391595003058 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 391595003059 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 391595003060 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595003061 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 391595003062 active site 391595003063 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391595003064 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 391595003065 conserved cys residue [active] 391595003066 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 391595003067 DJ-1 family protein; Region: not_thiJ; TIGR01383 391595003068 conserved cys residue [active] 391595003069 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 391595003070 Transposase; Region: HTH_Tnp_1; pfam01527 391595003071 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391595003072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391595003073 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391595003074 VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370 391595003075 DctM-like transporters; Region: DctM; pfam06808 391595003076 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391595003077 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391595003078 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595003079 hypothetical protein; Provisional; Region: PRK05463 391595003080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595003081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595003082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391595003083 dimerization interface [polypeptide binding]; other site 391595003084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 391595003085 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391595003086 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391595003087 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391595003088 MarR family; Region: MarR_2; pfam12802 391595003089 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391595003090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391595003091 Coenzyme A binding pocket [chemical binding]; other site 391595003092 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391595003093 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 391595003094 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 391595003095 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391595003096 active site 391595003097 metal binding site [ion binding]; metal-binding site 391595003098 hexamer interface [polypeptide binding]; other site 391595003099 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 391595003100 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391595003101 active site 391595003102 metal binding site [ion binding]; metal-binding site 391595003103 hexamer interface [polypeptide binding]; other site 391595003104 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595003105 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391595003106 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595003107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595003108 dimer interface [polypeptide binding]; other site 391595003109 conserved gate region; other site 391595003110 putative PBP binding loops; other site 391595003111 ABC-ATPase subunit interface; other site 391595003112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595003113 putative PBP binding loops; other site 391595003114 ABC-ATPase subunit interface; other site 391595003115 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595003116 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391595003117 Walker A/P-loop; other site 391595003118 ATP binding site [chemical binding]; other site 391595003119 Q-loop/lid; other site 391595003120 ABC transporter signature motif; other site 391595003121 Walker B; other site 391595003122 D-loop; other site 391595003123 H-loop/switch region; other site 391595003124 TOBE domain; Region: TOBE_2; pfam08402 391595003125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595003126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595003127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391595003128 dimerization interface [polypeptide binding]; other site 391595003129 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391595003130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391595003131 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391595003132 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391595003133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391595003134 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391595003135 Integrase core domain; Region: rve; pfam00665 391595003136 Predicted transcriptional regulator [Transcription]; Region: COG1959 391595003137 Transcriptional regulator; Region: Rrf2; pfam02082 391595003138 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 391595003139 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 391595003140 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 391595003141 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391595003142 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 391595003143 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 391595003144 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595003145 Walker A/P-loop; other site 391595003146 ATP binding site [chemical binding]; other site 391595003147 Q-loop/lid; other site 391595003148 ABC transporter signature motif; other site 391595003149 Walker B; other site 391595003150 D-loop; other site 391595003151 H-loop/switch region; other site 391595003152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595003153 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 391595003154 Walker A/P-loop; other site 391595003155 ATP binding site [chemical binding]; other site 391595003156 Q-loop/lid; other site 391595003157 ABC transporter signature motif; other site 391595003158 Walker B; other site 391595003159 D-loop; other site 391595003160 H-loop/switch region; other site 391595003161 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391595003162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391595003163 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391595003164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595003165 dimer interface [polypeptide binding]; other site 391595003166 conserved gate region; other site 391595003167 putative PBP binding loops; other site 391595003168 ABC-ATPase subunit interface; other site 391595003169 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595003170 EamA-like transporter family; Region: EamA; pfam00892 391595003171 hypothetical protein; Provisional; Region: PRK06194 391595003172 classical (c) SDRs; Region: SDR_c; cd05233 391595003173 NAD(P) binding site [chemical binding]; other site 391595003174 active site 391595003175 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391595003176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391595003177 DNA binding site [nucleotide binding] 391595003178 BCCT family transporter; Region: BCCT; pfam02028 391595003179 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 391595003180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595003181 Response regulator receiver domain; Region: Response_reg; pfam00072 391595003182 active site 391595003183 phosphorylation site [posttranslational modification] 391595003184 intermolecular recognition site; other site 391595003185 dimerization interface [polypeptide binding]; other site 391595003186 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391595003187 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391595003188 DNA binding residues [nucleotide binding] 391595003189 dimerization interface [polypeptide binding]; other site 391595003190 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 391595003191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595003192 dimer interface [polypeptide binding]; other site 391595003193 phosphorylation site [posttranslational modification] 391595003194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595003195 ATP binding site [chemical binding]; other site 391595003196 Mg2+ binding site [ion binding]; other site 391595003197 G-X-G motif; other site 391595003198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595003199 active site 391595003200 phosphorylation site [posttranslational modification] 391595003201 intermolecular recognition site; other site 391595003202 dimerization interface [polypeptide binding]; other site 391595003203 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391595003204 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 391595003205 putative ligand binding site [chemical binding]; other site 391595003206 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595003207 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391595003208 TM-ABC transporter signature motif; other site 391595003209 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391595003210 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391595003211 TM-ABC transporter signature motif; other site 391595003212 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 391595003213 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391595003214 Walker A/P-loop; other site 391595003215 ATP binding site [chemical binding]; other site 391595003216 Q-loop/lid; other site 391595003217 ABC transporter signature motif; other site 391595003218 Walker B; other site 391595003219 D-loop; other site 391595003220 H-loop/switch region; other site 391595003221 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 391595003222 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391595003223 Walker A/P-loop; other site 391595003224 ATP binding site [chemical binding]; other site 391595003225 Q-loop/lid; other site 391595003226 ABC transporter signature motif; other site 391595003227 Walker B; other site 391595003228 D-loop; other site 391595003229 H-loop/switch region; other site 391595003230 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 391595003231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595003232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595003233 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391595003234 dimerization interface [polypeptide binding]; other site 391595003235 Protein of unknown function, DUF481; Region: DUF481; pfam04338 391595003236 4-coumarate--CoA ligase; Region: PLN02246 391595003237 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 391595003238 acyl-activating enzyme (AAE) consensus motif; other site 391595003239 active site 391595003240 putative CoA binding site [chemical binding]; other site 391595003241 AMP binding site [chemical binding]; other site 391595003242 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 391595003243 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 391595003244 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 391595003245 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 391595003246 dimer interface [polypeptide binding]; other site 391595003247 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391595003248 active site 391595003249 metal binding site [ion binding]; metal-binding site 391595003250 glutathione binding site [chemical binding]; other site 391595003251 thymidylate synthase; Reviewed; Region: thyA; PRK01827 391595003252 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 391595003253 dimerization interface [polypeptide binding]; other site 391595003254 active site 391595003255 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 391595003256 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 391595003257 NADP+ binding site [chemical binding]; other site 391595003258 folate binding site [chemical binding]; other site 391595003259 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391595003260 DNA-binding site [nucleotide binding]; DNA binding site 391595003261 RNA-binding motif; other site 391595003262 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391595003263 ArsC family; Region: ArsC; pfam03960 391595003264 Predicted membrane protein [Function unknown]; Region: COG2259 391595003265 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 391595003266 hypothetical protein; Provisional; Region: PRK05409 391595003267 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 391595003268 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 391595003269 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 391595003270 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 391595003271 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 391595003272 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 391595003273 active site 391595003274 dimer interface [polypeptide binding]; other site 391595003275 motif 1; other site 391595003276 motif 2; other site 391595003277 motif 3; other site 391595003278 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 391595003279 anticodon binding site; other site 391595003280 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391595003281 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 391595003282 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 391595003283 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 391595003284 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 391595003285 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 391595003286 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 391595003287 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 391595003288 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 391595003289 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 391595003290 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391595003291 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595003292 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391595003293 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391595003294 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391595003295 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 391595003296 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 391595003297 catalytic triad [active] 391595003298 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391595003299 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391595003300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595003301 dimer interface [polypeptide binding]; other site 391595003302 conserved gate region; other site 391595003303 putative PBP binding loops; other site 391595003304 ABC-ATPase subunit interface; other site 391595003305 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391595003306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595003307 ABC-ATPase subunit interface; other site 391595003308 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391595003309 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391595003310 substrate binding pocket [chemical binding]; other site 391595003311 membrane-bound complex binding site; other site 391595003312 hinge residues; other site 391595003313 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 391595003314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595003315 Walker A/P-loop; other site 391595003316 ATP binding site [chemical binding]; other site 391595003317 Q-loop/lid; other site 391595003318 ABC transporter signature motif; other site 391595003319 Walker B; other site 391595003320 D-loop; other site 391595003321 H-loop/switch region; other site 391595003322 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 391595003323 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 391595003324 putative metal binding site [ion binding]; other site 391595003325 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 391595003326 putative metal binding site [ion binding]; other site 391595003327 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 391595003328 CTP synthetase; Validated; Region: pyrG; PRK05380 391595003329 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 391595003330 Catalytic site [active] 391595003331 active site 391595003332 UTP binding site [chemical binding]; other site 391595003333 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 391595003334 active site 391595003335 putative oxyanion hole; other site 391595003336 catalytic triad [active] 391595003337 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 391595003338 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 391595003339 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 391595003340 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 391595003341 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 391595003342 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 391595003343 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 391595003344 GDP-binding site [chemical binding]; other site 391595003345 ACT binding site; other site 391595003346 IMP binding site; other site 391595003347 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 391595003348 Thiamine pyrophosphokinase; Region: TPK; cd07995 391595003349 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 391595003350 active site 391595003351 dimerization interface [polypeptide binding]; other site 391595003352 thiamine binding site [chemical binding]; other site 391595003353 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595003354 EamA-like transporter family; Region: EamA; pfam00892 391595003355 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 391595003356 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 391595003357 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 391595003358 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391595003359 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 391595003360 C-terminal domain interface [polypeptide binding]; other site 391595003361 GSH binding site (G-site) [chemical binding]; other site 391595003362 dimer interface [polypeptide binding]; other site 391595003363 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 391595003364 dimer interface [polypeptide binding]; other site 391595003365 N-terminal domain interface [polypeptide binding]; other site 391595003366 substrate binding pocket (H-site) [chemical binding]; other site 391595003367 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 391595003368 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391595003369 active site 391595003370 dimer interface [polypeptide binding]; other site 391595003371 glutathione reductase; Validated; Region: PRK06116 391595003372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595003373 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391595003374 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391595003375 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 391595003376 HflK protein; Region: hflK; TIGR01933 391595003377 HflC protein; Region: hflC; TIGR01932 391595003378 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 391595003379 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 391595003380 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 391595003381 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391595003382 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391595003383 protein binding site [polypeptide binding]; other site 391595003384 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391595003385 protein binding site [polypeptide binding]; other site 391595003386 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 391595003387 generic binding surface I; other site 391595003388 generic binding surface II; other site 391595003389 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 391595003390 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391595003391 catalytic loop [active] 391595003392 iron binding site [ion binding]; other site 391595003393 Family description; Region: VCBS; pfam13517 391595003394 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 391595003395 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 391595003396 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 391595003397 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 391595003398 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 391595003399 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 391595003400 generic binding surface I; other site 391595003401 generic binding surface II; other site 391595003402 endoglucanase; Region: PLN02340 391595003403 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 391595003404 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 391595003405 putative dimer interface [polypeptide binding]; other site 391595003406 [2Fe-2S] cluster binding site [ion binding]; other site 391595003407 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 391595003408 SLBB domain; Region: SLBB; pfam10531 391595003409 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 391595003410 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 391595003411 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 391595003412 P loop; other site 391595003413 GTP binding site [chemical binding]; other site 391595003414 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 391595003415 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 391595003416 Intracellular septation protein A; Region: IspA; pfam04279 391595003417 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391595003418 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595003419 ligand binding site [chemical binding]; other site 391595003420 flexible hinge region; other site 391595003421 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 391595003422 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 391595003423 C-terminal domain interface [polypeptide binding]; other site 391595003424 GSH binding site (G-site) [chemical binding]; other site 391595003425 dimer interface [polypeptide binding]; other site 391595003426 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391595003427 N-terminal domain interface [polypeptide binding]; other site 391595003428 dimer interface [polypeptide binding]; other site 391595003429 substrate binding pocket (H-site) [chemical binding]; other site 391595003430 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 391595003431 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 391595003432 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 391595003433 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 391595003434 homodimer interface [polypeptide binding]; other site 391595003435 substrate-cofactor binding pocket; other site 391595003436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595003437 catalytic residue [active] 391595003438 putative GTP cyclohydrolase; Provisional; Region: PRK13674 391595003439 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 391595003440 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 391595003441 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391595003442 hypothetical protein; Provisional; Region: PRK07524 391595003443 PYR/PP interface [polypeptide binding]; other site 391595003444 dimer interface [polypeptide binding]; other site 391595003445 TPP binding site [chemical binding]; other site 391595003446 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391595003447 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 391595003448 TPP-binding site [chemical binding]; other site 391595003449 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391595003450 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391595003451 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 391595003452 motif 1; other site 391595003453 dimer interface [polypeptide binding]; other site 391595003454 active site 391595003455 motif 2; other site 391595003456 motif 3; other site 391595003457 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 391595003458 DALR anticodon binding domain; Region: DALR_1; pfam05746 391595003459 pyruvate phosphate dikinase; Provisional; Region: PRK09279 391595003460 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 391595003461 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391595003462 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 391595003463 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 391595003464 Dihydroneopterin aldolase; Region: FolB; smart00905 391595003465 active site 391595003466 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 391595003467 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 391595003468 dihydropteroate synthase; Region: DHPS; TIGR01496 391595003469 substrate binding pocket [chemical binding]; other site 391595003470 dimer interface [polypeptide binding]; other site 391595003471 inhibitor binding site; inhibition site 391595003472 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 391595003473 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 391595003474 active site 391595003475 substrate binding site [chemical binding]; other site 391595003476 metal binding site [ion binding]; metal-binding site 391595003477 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 391595003478 EamA-like transporter family; Region: EamA; pfam00892 391595003479 ketol-acid reductoisomerase; Provisional; Region: PRK05479 391595003480 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 391595003481 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 391595003482 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595003483 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 391595003484 putative DNA binding site [nucleotide binding]; other site 391595003485 putative Zn2+ binding site [ion binding]; other site 391595003486 AsnC family; Region: AsnC_trans_reg; pfam01037 391595003487 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595003488 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595003489 putative DNA binding site [nucleotide binding]; other site 391595003490 putative Zn2+ binding site [ion binding]; other site 391595003491 AsnC family; Region: AsnC_trans_reg; pfam01037 391595003492 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 391595003493 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595003494 catalytic residue [active] 391595003495 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 391595003496 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391595003497 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 391595003498 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 391595003499 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391595003500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595003501 DNA-binding site [nucleotide binding]; DNA binding site 391595003502 FCD domain; Region: FCD; pfam07729 391595003503 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 391595003504 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 391595003505 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 391595003506 DXD motif; other site 391595003507 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 391595003508 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 391595003509 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 391595003510 catalytic site [active] 391595003511 subunit interface [polypeptide binding]; other site 391595003512 Yqey-like protein; Region: YqeY; pfam09424 391595003513 Predicted transcriptional regulator [Transcription]; Region: COG2378 391595003514 HTH domain; Region: HTH_11; pfam08279 391595003515 WYL domain; Region: WYL; pfam13280 391595003516 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 391595003517 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 391595003518 Subunit I/III interface [polypeptide binding]; other site 391595003519 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 391595003520 D-pathway; other site 391595003521 Subunit I/VIIc interface [polypeptide binding]; other site 391595003522 Subunit I/IV interface [polypeptide binding]; other site 391595003523 Subunit I/II interface [polypeptide binding]; other site 391595003524 Low-spin heme (heme a) binding site [chemical binding]; other site 391595003525 Subunit I/VIIa interface [polypeptide binding]; other site 391595003526 Subunit I/VIa interface [polypeptide binding]; other site 391595003527 Dimer interface; other site 391595003528 Putative water exit pathway; other site 391595003529 Binuclear center (heme a3/CuB) [ion binding]; other site 391595003530 K-pathway; other site 391595003531 Subunit I/Vb interface [polypeptide binding]; other site 391595003532 Putative proton exit pathway; other site 391595003533 Subunit I/VIb interface; other site 391595003534 Subunit I/VIc interface [polypeptide binding]; other site 391595003535 Electron transfer pathway; other site 391595003536 Subunit I/VIIIb interface [polypeptide binding]; other site 391595003537 Subunit I/VIIb interface [polypeptide binding]; other site 391595003538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391595003539 PAS fold; Region: PAS_3; pfam08447 391595003540 putative active site [active] 391595003541 heme pocket [chemical binding]; other site 391595003542 lipoate-protein ligase B; Provisional; Region: PRK14341 391595003543 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 391595003544 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 391595003545 RelB antitoxin; Region: RelB; cl01171 391595003546 multiple promoter invertase; Provisional; Region: mpi; PRK13413 391595003547 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391595003548 catalytic residues [active] 391595003549 catalytic nucleophile [active] 391595003550 Presynaptic Site I dimer interface [polypeptide binding]; other site 391595003551 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391595003552 Synaptic Flat tetramer interface [polypeptide binding]; other site 391595003553 Synaptic Site I dimer interface [polypeptide binding]; other site 391595003554 DNA binding site [nucleotide binding] 391595003555 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391595003556 DNA-binding interface [nucleotide binding]; DNA binding site 391595003557 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 391595003558 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 391595003559 ThiF family; Region: ThiF; pfam00899 391595003560 ATP binding site [chemical binding]; other site 391595003561 substrate interface [chemical binding]; other site 391595003562 Fic family protein [Function unknown]; Region: COG3177 391595003563 Fic/DOC family; Region: Fic; pfam02661 391595003564 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 391595003565 Antirestriction protein (ArdA); Region: ArdA; cl01953 391595003566 Transposase; Region: HTH_Tnp_1; pfam01527 391595003567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391595003568 HTH-like domain; Region: HTH_21; pfam13276 391595003569 Integrase core domain; Region: rve; pfam00665 391595003570 Integrase core domain; Region: rve_3; pfam13683 391595003571 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 391595003572 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 391595003573 Int/Topo IB signature motif; other site 391595003574 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391595003575 integron integrase; Region: integrase_gron; TIGR02249 391595003576 active site 391595003577 DNA binding site [nucleotide binding] 391595003578 Int/Topo IB signature motif; other site 391595003579 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 391595003580 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 391595003581 Int/Topo IB signature motif; other site 391595003582 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 391595003583 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 391595003584 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595003585 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595003586 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595003587 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 391595003588 Helix-turn-helix domain; Region: HTH_18; pfam12833 391595003589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595003590 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 391595003591 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595003592 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 391595003593 active site 391595003594 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 391595003595 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 391595003596 Surface antigen; Region: Bac_surface_Ag; pfam01103 391595003597 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391595003598 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391595003599 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391595003600 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391595003601 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 391595003602 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 391595003603 PLD-like domain; Region: PLDc_2; pfam13091 391595003604 putative active site [active] 391595003605 catalytic site [active] 391595003606 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 391595003607 PLD-like domain; Region: PLDc_2; pfam13091 391595003608 putative active site [active] 391595003609 catalytic site [active] 391595003610 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 391595003611 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595003612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595003613 Walker A/P-loop; other site 391595003614 ATP binding site [chemical binding]; other site 391595003615 Q-loop/lid; other site 391595003616 ABC transporter signature motif; other site 391595003617 Walker B; other site 391595003618 D-loop; other site 391595003619 H-loop/switch region; other site 391595003620 AMP-binding domain protein; Validated; Region: PRK07529 391595003621 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391595003622 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391595003623 acyl-activating enzyme (AAE) consensus motif; other site 391595003624 AMP binding site [chemical binding]; other site 391595003625 active site 391595003626 CoA binding site [chemical binding]; other site 391595003627 Uncharacterized conserved protein [Function unknown]; Region: COG3379 391595003628 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 391595003629 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391595003630 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595003631 Walker A/P-loop; other site 391595003632 ATP binding site [chemical binding]; other site 391595003633 Q-loop/lid; other site 391595003634 ABC transporter signature motif; other site 391595003635 Walker B; other site 391595003636 D-loop; other site 391595003637 H-loop/switch region; other site 391595003638 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391595003639 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595003640 Walker A/P-loop; other site 391595003641 ATP binding site [chemical binding]; other site 391595003642 Q-loop/lid; other site 391595003643 ABC transporter signature motif; other site 391595003644 Walker B; other site 391595003645 D-loop; other site 391595003646 H-loop/switch region; other site 391595003647 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391595003648 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391595003649 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391595003650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595003651 dimer interface [polypeptide binding]; other site 391595003652 conserved gate region; other site 391595003653 putative PBP binding loops; other site 391595003654 ABC-ATPase subunit interface; other site 391595003655 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391595003656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595003657 dimer interface [polypeptide binding]; other site 391595003658 conserved gate region; other site 391595003659 ABC-ATPase subunit interface; other site 391595003660 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391595003661 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391595003662 Predicted acyl esterases [General function prediction only]; Region: COG2936 391595003663 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 391595003664 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 391595003665 MOFRL family; Region: MOFRL; pfam05161 391595003666 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 391595003667 putative active site [active] 391595003668 dimerization interface [polypeptide binding]; other site 391595003669 putative tRNAtyr binding site [nucleotide binding]; other site 391595003670 transcription initiation factor IIB; Reviewed; Region: tfb; PRK00423 391595003671 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 391595003672 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 391595003673 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 391595003674 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 391595003675 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 391595003676 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 391595003677 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391595003678 RNA binding surface [nucleotide binding]; other site 391595003679 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 391595003680 active site 391595003681 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 391595003682 nucleoside/Zn binding site; other site 391595003683 dimer interface [polypeptide binding]; other site 391595003684 catalytic motif [active] 391595003685 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391595003686 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391595003687 Ceramidase; Region: Ceramidase; pfam05875 391595003688 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 391595003689 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391595003690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595003691 non-specific DNA binding site [nucleotide binding]; other site 391595003692 salt bridge; other site 391595003693 sequence-specific DNA binding site [nucleotide binding]; other site 391595003694 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 391595003695 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 391595003696 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 391595003697 amidase catalytic site [active] 391595003698 Zn binding residues [ion binding]; other site 391595003699 substrate binding site [chemical binding]; other site 391595003700 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391595003701 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 391595003702 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 391595003703 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 391595003704 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 391595003705 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 391595003706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595003707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595003708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595003709 dimerization interface [polypeptide binding]; other site 391595003710 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391595003711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595003712 non-specific DNA binding site [nucleotide binding]; other site 391595003713 salt bridge; other site 391595003714 sequence-specific DNA binding site [nucleotide binding]; other site 391595003715 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391595003716 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 391595003717 active site 391595003718 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 391595003719 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 391595003720 active site 391595003721 putative substrate binding pocket [chemical binding]; other site 391595003722 guanine deaminase; Provisional; Region: PRK09228 391595003723 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 391595003724 active site 391595003725 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 391595003726 MgtE intracellular N domain; Region: MgtE_N; smart00924 391595003727 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 391595003728 Divalent cation transporter; Region: MgtE; cl00786 391595003729 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 391595003730 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 391595003731 putative active site [active] 391595003732 metal binding site [ion binding]; metal-binding site 391595003733 homodimer binding site [polypeptide binding]; other site 391595003734 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595003735 EamA-like transporter family; Region: EamA; pfam00892 391595003736 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 391595003737 transmembrane helices; other site 391595003738 TrkA-C domain; Region: TrkA_C; pfam02080 391595003739 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 391595003740 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 391595003741 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 391595003742 transmembrane helices; other site 391595003743 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 391595003744 TrkA-C domain; Region: TrkA_C; pfam02080 391595003745 TrkA-C domain; Region: TrkA_C; pfam02080 391595003746 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 391595003747 hypothetical protein; Validated; Region: PRK00110 391595003748 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595003749 EamA-like transporter family; Region: EamA; pfam00892 391595003750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595003751 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 391595003752 Sulfatase; Region: Sulfatase; cl17466 391595003753 choline-sulfatase; Region: chol_sulfatase; TIGR03417 391595003754 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 391595003755 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 391595003756 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391595003757 NAD(P) binding site [chemical binding]; other site 391595003758 catalytic residues [active] 391595003759 choline dehydrogenase; Validated; Region: PRK02106 391595003760 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391595003761 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391595003762 Staphylococcal nuclease homologues; Region: SNc; smart00318 391595003763 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 391595003764 Catalytic site; other site 391595003765 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391595003766 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595003767 non-specific DNA binding site [nucleotide binding]; other site 391595003768 salt bridge; other site 391595003769 sequence-specific DNA binding site [nucleotide binding]; other site 391595003770 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 391595003771 Domain of unknown function (DUF955); Region: DUF955; pfam06114 391595003772 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 391595003773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595003774 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 391595003775 putative substrate translocation pore; other site 391595003776 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 391595003777 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 391595003778 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 391595003779 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 391595003780 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 391595003781 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391595003782 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 391595003783 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391595003784 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391595003785 carboxyltransferase (CT) interaction site; other site 391595003786 biotinylation site [posttranslational modification]; other site 391595003787 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 391595003788 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 391595003789 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 391595003790 active site 391595003791 substrate binding site [chemical binding]; other site 391595003792 coenzyme B12 binding site [chemical binding]; other site 391595003793 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 391595003794 B12 binding site [chemical binding]; other site 391595003795 cobalt ligand [ion binding]; other site 391595003796 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 391595003797 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 391595003798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391595003799 Coenzyme A binding pocket [chemical binding]; other site 391595003800 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 391595003801 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 391595003802 putative metal binding site [ion binding]; other site 391595003803 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391595003804 HSP70 interaction site [polypeptide binding]; other site 391595003805 exopolyphosphatase; Region: exo_poly_only; TIGR03706 391595003806 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 391595003807 polyphosphate kinase; Provisional; Region: PRK05443 391595003808 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 391595003809 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 391595003810 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 391595003811 putative domain interface [polypeptide binding]; other site 391595003812 putative active site [active] 391595003813 catalytic site [active] 391595003814 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 391595003815 putative domain interface [polypeptide binding]; other site 391595003816 putative active site [active] 391595003817 catalytic site [active] 391595003818 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 391595003819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391595003820 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 391595003821 Domain of unknown function DUF20; Region: UPF0118; pfam01594 391595003822 prolyl-tRNA synthetase; Provisional; Region: PRK12325 391595003823 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 391595003824 dimer interface [polypeptide binding]; other site 391595003825 motif 1; other site 391595003826 active site 391595003827 motif 2; other site 391595003828 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391595003829 active site 391595003830 motif 3; other site 391595003831 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 391595003832 anticodon binding site; other site 391595003833 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 391595003834 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 391595003835 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391595003836 FtsX-like permease family; Region: FtsX; pfam02687 391595003837 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391595003838 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391595003839 Walker A/P-loop; other site 391595003840 ATP binding site [chemical binding]; other site 391595003841 Q-loop/lid; other site 391595003842 ABC transporter signature motif; other site 391595003843 Walker B; other site 391595003844 D-loop; other site 391595003845 H-loop/switch region; other site 391595003846 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 391595003847 Protein of unknown function, DUF606; Region: DUF606; pfam04657 391595003848 Cytochrome c; Region: Cytochrom_C; cl11414 391595003849 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 391595003850 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 391595003851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595003852 ATP binding site [chemical binding]; other site 391595003853 Mg2+ binding site [ion binding]; other site 391595003854 G-X-G motif; other site 391595003855 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 391595003856 anchoring element; other site 391595003857 dimer interface [polypeptide binding]; other site 391595003858 ATP binding site [chemical binding]; other site 391595003859 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 391595003860 active site 391595003861 metal binding site [ion binding]; metal-binding site 391595003862 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 391595003863 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 391595003864 multidrug efflux protein; Reviewed; Region: PRK01766 391595003865 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 391595003866 cation binding site [ion binding]; other site 391595003867 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391595003868 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391595003869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595003870 NAD(P) binding site [chemical binding]; other site 391595003871 active site 391595003872 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595003873 Phosphotransferase enzyme family; Region: APH; pfam01636 391595003874 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 391595003875 putative active site [active] 391595003876 putative substrate binding site [chemical binding]; other site 391595003877 ATP binding site [chemical binding]; other site 391595003878 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391595003879 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391595003880 active site 391595003881 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 391595003882 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595003883 active site 391595003884 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 391595003885 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 391595003886 dimerization interface 3.5A [polypeptide binding]; other site 391595003887 active site 391595003888 YcjX-like family, DUF463; Region: DUF463; pfam04317 391595003889 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391595003890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391595003891 Coenzyme A binding pocket [chemical binding]; other site 391595003892 hypothetical protein; Provisional; Region: PRK05415 391595003893 Domain of unknown function (DUF697); Region: DUF697; pfam05128 391595003894 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 391595003895 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391595003896 active site 391595003897 HIGH motif; other site 391595003898 nucleotide binding site [chemical binding]; other site 391595003899 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 391595003900 active site 391595003901 KMSKS motif; other site 391595003902 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 391595003903 tRNA binding surface [nucleotide binding]; other site 391595003904 anticodon binding site; other site 391595003905 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 391595003906 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 391595003907 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 391595003908 DNA binding site [nucleotide binding] 391595003909 active site 391595003910 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 391595003911 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391595003912 active site 391595003913 DNA binding site [nucleotide binding] 391595003914 Int/Topo IB signature motif; other site 391595003915 Protein of unknown function, DUF484; Region: DUF484; cl17449 391595003916 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 391595003917 active site 391595003918 intersubunit interactions; other site 391595003919 catalytic residue [active] 391595003920 primosome assembly protein PriA; Validated; Region: PRK05580 391595003921 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391595003922 ATP binding site [chemical binding]; other site 391595003923 putative Mg++ binding site [ion binding]; other site 391595003924 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 391595003925 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 391595003926 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 391595003927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595003928 S-adenosylmethionine binding site [chemical binding]; other site 391595003929 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391595003930 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 391595003931 active site 391595003932 putative DNA-binding cleft [nucleotide binding]; other site 391595003933 dimer interface [polypeptide binding]; other site 391595003934 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 391595003935 RuvA N terminal domain; Region: RuvA_N; pfam01330 391595003936 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 391595003937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595003938 Walker A motif; other site 391595003939 ATP binding site [chemical binding]; other site 391595003940 Walker B motif; other site 391595003941 arginine finger; other site 391595003942 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 391595003943 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391595003944 active site 391595003945 TolQ protein; Region: tolQ; TIGR02796 391595003946 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 391595003947 TolR protein; Region: tolR; TIGR02801 391595003948 translocation protein TolB; Provisional; Region: tolB; PRK05137 391595003949 TolB amino-terminal domain; Region: TolB_N; pfam04052 391595003950 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391595003951 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391595003952 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391595003953 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391595003954 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391595003955 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391595003956 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391595003957 ligand binding site [chemical binding]; other site 391595003958 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 391595003959 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 391595003960 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 391595003961 FtsH Extracellular; Region: FtsH_ext; pfam06480 391595003962 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 391595003963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595003964 Walker A motif; other site 391595003965 ATP binding site [chemical binding]; other site 391595003966 Walker B motif; other site 391595003967 arginine finger; other site 391595003968 Peptidase family M41; Region: Peptidase_M41; pfam01434 391595003969 MOSC domain; Region: MOSC; pfam03473 391595003970 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 391595003971 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 391595003972 Potassium binding sites [ion binding]; other site 391595003973 Cesium cation binding sites [ion binding]; other site 391595003974 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 391595003975 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 391595003976 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 391595003977 homodimer interface [polypeptide binding]; other site 391595003978 NADP binding site [chemical binding]; other site 391595003979 substrate binding site [chemical binding]; other site 391595003980 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391595003981 CoenzymeA binding site [chemical binding]; other site 391595003982 subunit interaction site [polypeptide binding]; other site 391595003983 PHB binding site; other site 391595003984 metallophosphoesterase, DNA ligase-associated; Region: P_estr_lig_assc; TIGR04123 391595003985 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 391595003986 active site 391595003987 metal binding site [ion binding]; metal-binding site 391595003988 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 391595003989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391595003990 ATP binding site [chemical binding]; other site 391595003991 putative Mg++ binding site [ion binding]; other site 391595003992 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391595003993 nucleotide binding region [chemical binding]; other site 391595003994 ATP-binding site [chemical binding]; other site 391595003995 DEAD/H associated; Region: DEAD_assoc; pfam08494 391595003996 RNA helicase; Region: RNA_helicase; pfam00910 391595003997 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 391595003998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595003999 binding surface 391595004000 TPR motif; other site 391595004001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595004002 binding surface 391595004003 TPR motif; other site 391595004004 Tetratricopeptide repeat; Region: TPR_16; pfam13432 391595004005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595004006 TPR motif; other site 391595004007 binding surface 391595004008 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 391595004009 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 391595004010 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 391595004011 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 391595004012 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 391595004013 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 391595004014 ATP binding site [chemical binding]; other site 391595004015 Walker A motif; other site 391595004016 hexamer interface [polypeptide binding]; other site 391595004017 Walker B motif; other site 391595004018 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 391595004019 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 391595004020 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 391595004021 BON domain; Region: BON; pfam04972 391595004022 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 391595004023 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 391595004024 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 391595004025 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391595004026 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391595004027 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391595004028 catalytic residue [active] 391595004029 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 391595004030 PAS domain; Region: PAS_9; pfam13426 391595004031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391595004032 putative active site [active] 391595004033 heme pocket [chemical binding]; other site 391595004034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 391595004035 Histidine kinase; Region: HisKA_2; pfam07568 391595004036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595004037 ATP binding site [chemical binding]; other site 391595004038 Mg2+ binding site [ion binding]; other site 391595004039 G-X-G motif; other site 391595004040 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 391595004041 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 391595004042 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 391595004043 active site 391595004044 interdomain interaction site; other site 391595004045 putative metal-binding site [ion binding]; other site 391595004046 nucleotide binding site [chemical binding]; other site 391595004047 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 391595004048 domain I; other site 391595004049 DNA binding groove [nucleotide binding] 391595004050 phosphate binding site [ion binding]; other site 391595004051 domain II; other site 391595004052 domain III; other site 391595004053 nucleotide binding site [chemical binding]; other site 391595004054 catalytic site [active] 391595004055 domain IV; other site 391595004056 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 391595004057 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391595004058 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391595004059 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391595004060 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 391595004061 DNA protecting protein DprA; Region: dprA; TIGR00732 391595004062 protease TldD; Provisional; Region: tldD; PRK10735 391595004063 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 391595004064 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 391595004065 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 391595004066 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 391595004067 UbiA prenyltransferase family; Region: UbiA; pfam01040 391595004068 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 391595004069 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 391595004070 Subunit III/VIIa interface [polypeptide binding]; other site 391595004071 Phospholipid binding site [chemical binding]; other site 391595004072 Subunit I/III interface [polypeptide binding]; other site 391595004073 Subunit III/VIb interface [polypeptide binding]; other site 391595004074 Subunit III/VIa interface; other site 391595004075 Subunit III/Vb interface [polypeptide binding]; other site 391595004076 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 391595004077 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 391595004078 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 391595004079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595004080 catalytic residue [active] 391595004081 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391595004082 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391595004083 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391595004084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391595004085 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391595004086 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391595004087 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 391595004088 FAD binding domain; Region: FAD_binding_4; pfam01565 391595004089 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 391595004090 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 391595004091 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391595004092 active site 391595004093 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391595004094 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 391595004095 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 391595004096 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 391595004097 Sulfate transporter family; Region: Sulfate_transp; pfam00916 391595004098 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 391595004099 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 391595004100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391595004101 Coenzyme A binding pocket [chemical binding]; other site 391595004102 EcsC protein family; Region: EcsC; pfam12787 391595004103 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 391595004104 nudix motif; other site 391595004105 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 391595004106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595004107 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 391595004108 NAD(P) binding site [chemical binding]; other site 391595004109 active site 391595004110 aspartate kinase; Reviewed; Region: PRK06635 391595004111 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 391595004112 putative nucleotide binding site [chemical binding]; other site 391595004113 putative catalytic residues [active] 391595004114 putative Mg ion binding site [ion binding]; other site 391595004115 putative aspartate binding site [chemical binding]; other site 391595004116 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 391595004117 putative allosteric regulatory site; other site 391595004118 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 391595004119 putative allosteric regulatory residue; other site 391595004120 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 391595004121 GAF domain; Region: GAF; pfam01590 391595004122 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 391595004123 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391595004124 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 391595004125 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 391595004126 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 391595004127 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 391595004128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 391595004129 ACT domain; Region: ACT_3; pfam10000 391595004130 Family description; Region: ACT_7; pfam13840 391595004131 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391595004132 dimerization interface [polypeptide binding]; other site 391595004133 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391595004134 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391595004135 dimer interface [polypeptide binding]; other site 391595004136 putative CheW interface [polypeptide binding]; other site 391595004137 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 391595004138 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391595004139 Walker A/P-loop; other site 391595004140 ATP binding site [chemical binding]; other site 391595004141 Q-loop/lid; other site 391595004142 ABC transporter signature motif; other site 391595004143 Walker B; other site 391595004144 D-loop; other site 391595004145 H-loop/switch region; other site 391595004146 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 391595004147 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391595004148 Walker A/P-loop; other site 391595004149 ATP binding site [chemical binding]; other site 391595004150 Q-loop/lid; other site 391595004151 ABC transporter signature motif; other site 391595004152 Walker B; other site 391595004153 D-loop; other site 391595004154 H-loop/switch region; other site 391595004155 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391595004156 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391595004157 TM-ABC transporter signature motif; other site 391595004158 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391595004159 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595004160 TM-ABC transporter signature motif; other site 391595004161 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391595004162 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 391595004163 putative ligand binding site [chemical binding]; other site 391595004164 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 391595004165 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 391595004166 putative active site [active] 391595004167 metal binding site [ion binding]; metal-binding site 391595004168 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391595004169 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 391595004170 NAD(P) binding site [chemical binding]; other site 391595004171 catalytic residues [active] 391595004172 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391595004173 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391595004174 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391595004175 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595004176 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391595004177 DctM-like transporters; Region: DctM; pfam06808 391595004178 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391595004179 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391595004180 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391595004181 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 391595004182 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 391595004183 putative active site [active] 391595004184 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 391595004185 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 391595004186 cobyric acid synthase; Provisional; Region: PRK00784 391595004187 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 391595004188 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 391595004189 catalytic triad [active] 391595004190 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 391595004191 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 391595004192 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 391595004193 homodimer interface [polypeptide binding]; other site 391595004194 Walker A motif; other site 391595004195 ATP binding site [chemical binding]; other site 391595004196 hydroxycobalamin binding site [chemical binding]; other site 391595004197 Walker B motif; other site 391595004198 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391595004199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391595004200 substrate binding pocket [chemical binding]; other site 391595004201 membrane-bound complex binding site; other site 391595004202 hinge residues; other site 391595004203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595004204 dimer interface [polypeptide binding]; other site 391595004205 conserved gate region; other site 391595004206 putative PBP binding loops; other site 391595004207 ABC-ATPase subunit interface; other site 391595004208 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391595004209 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391595004210 Walker A/P-loop; other site 391595004211 ATP binding site [chemical binding]; other site 391595004212 Q-loop/lid; other site 391595004213 ABC transporter signature motif; other site 391595004214 Walker B; other site 391595004215 D-loop; other site 391595004216 H-loop/switch region; other site 391595004217 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391595004218 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595004219 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391595004220 DctM-like transporters; Region: DctM; pfam06808 391595004221 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391595004222 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 391595004223 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 391595004224 tetramer interface [polypeptide binding]; other site 391595004225 active site 391595004226 Mg2+/Mn2+ binding site [ion binding]; other site 391595004227 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 391595004228 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 391595004229 putative active site [active] 391595004230 putative FMN binding site [chemical binding]; other site 391595004231 putative substrate binding site [chemical binding]; other site 391595004232 putative catalytic residue [active] 391595004233 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391595004234 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 391595004235 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391595004236 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 391595004237 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 391595004238 dimer interface [polypeptide binding]; other site 391595004239 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391595004240 active site 391595004241 metal binding site [ion binding]; metal-binding site 391595004242 glutathione binding site [chemical binding]; other site 391595004243 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 391595004244 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 391595004245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595004246 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 391595004247 dimerization interface [polypeptide binding]; other site 391595004248 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 391595004249 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 391595004250 heme binding site [chemical binding]; other site 391595004251 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 391595004252 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391595004253 Ligand Binding Site [chemical binding]; other site 391595004254 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 391595004255 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 391595004256 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 391595004257 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391595004258 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391595004259 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 391595004260 acyl-activating enzyme (AAE) consensus motif; other site 391595004261 acyl-activating enzyme (AAE) consensus motif; other site 391595004262 putative AMP binding site [chemical binding]; other site 391595004263 putative active site [active] 391595004264 putative CoA binding site [chemical binding]; other site 391595004265 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 391595004266 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391595004267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391595004268 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391595004269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595004270 non-specific DNA binding site [nucleotide binding]; other site 391595004271 salt bridge; other site 391595004272 sequence-specific DNA binding site [nucleotide binding]; other site 391595004273 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 391595004274 Domain of unknown function (DUF955); Region: DUF955; pfam06114 391595004275 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 391595004276 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 391595004277 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 391595004278 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391595004279 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391595004280 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391595004281 HlyD family secretion protein; Region: HlyD_3; pfam13437 391595004282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595004283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595004284 WHG domain; Region: WHG; pfam13305 391595004285 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391595004286 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 391595004287 active site 391595004288 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 391595004289 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391595004290 active site 391595004291 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391595004292 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391595004293 Walker A/P-loop; other site 391595004294 ATP binding site [chemical binding]; other site 391595004295 Q-loop/lid; other site 391595004296 ABC transporter signature motif; other site 391595004297 Walker B; other site 391595004298 D-loop; other site 391595004299 H-loop/switch region; other site 391595004300 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595004301 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391595004302 TM-ABC transporter signature motif; other site 391595004303 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391595004304 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391595004305 ligand binding site [chemical binding]; other site 391595004306 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595004307 putative DNA binding site [nucleotide binding]; other site 391595004308 dimerization interface [polypeptide binding]; other site 391595004309 putative Zn2+ binding site [ion binding]; other site 391595004310 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391595004311 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391595004312 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 391595004313 VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370 391595004314 GAF domain; Region: GAF; pfam01590 391595004315 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 391595004316 PAS domain; Region: PAS_9; pfam13426 391595004317 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391595004318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391595004319 metal binding site [ion binding]; metal-binding site 391595004320 active site 391595004321 I-site; other site 391595004322 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391595004323 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391595004324 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595004325 Walker A/P-loop; other site 391595004326 ATP binding site [chemical binding]; other site 391595004327 Q-loop/lid; other site 391595004328 ABC transporter signature motif; other site 391595004329 Walker B; other site 391595004330 D-loop; other site 391595004331 H-loop/switch region; other site 391595004332 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391595004333 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391595004334 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595004335 Walker A/P-loop; other site 391595004336 ATP binding site [chemical binding]; other site 391595004337 Q-loop/lid; other site 391595004338 ABC transporter signature motif; other site 391595004339 Walker B; other site 391595004340 D-loop; other site 391595004341 H-loop/switch region; other site 391595004342 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391595004343 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391595004344 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391595004345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595004346 dimer interface [polypeptide binding]; other site 391595004347 conserved gate region; other site 391595004348 putative PBP binding loops; other site 391595004349 ABC-ATPase subunit interface; other site 391595004350 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391595004351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595004352 dimer interface [polypeptide binding]; other site 391595004353 conserved gate region; other site 391595004354 putative PBP binding loops; other site 391595004355 ABC-ATPase subunit interface; other site 391595004356 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391595004357 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 391595004358 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 391595004359 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391595004360 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 391595004361 MobA/MobL family; Region: MobA_MobL; pfam03389 391595004362 Conjugal transfer protein TraD; Region: TraD; pfam06412 391595004363 Conjugal transfer protein TraD; Region: TraD; pfam06412 391595004364 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391595004365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595004366 active site 391595004367 phosphorylation site [posttranslational modification] 391595004368 intermolecular recognition site; other site 391595004369 dimerization interface [polypeptide binding]; other site 391595004370 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 391595004371 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 391595004372 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 391595004373 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 391595004374 putative CheA interaction surface; other site 391595004375 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 391595004376 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 391595004377 putative binding surface; other site 391595004378 active site 391595004379 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 391595004380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595004381 ATP binding site [chemical binding]; other site 391595004382 Mg2+ binding site [ion binding]; other site 391595004383 G-X-G motif; other site 391595004384 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 391595004385 Response regulator receiver domain; Region: Response_reg; pfam00072 391595004386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595004387 active site 391595004388 phosphorylation site [posttranslational modification] 391595004389 intermolecular recognition site; other site 391595004390 dimerization interface [polypeptide binding]; other site 391595004391 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 391595004392 anti sigma factor interaction site; other site 391595004393 regulatory phosphorylation site [posttranslational modification]; other site 391595004394 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 391595004395 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 391595004396 substrate binding pocket [chemical binding]; other site 391595004397 dimer interface [polypeptide binding]; other site 391595004398 inhibitor binding site; inhibition site 391595004399 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 391595004400 FAD binding site [chemical binding]; other site 391595004401 Virulence factor; Region: Virulence_fact; pfam13769 391595004402 exopolyphosphatase; Region: exo_poly_only; TIGR03706 391595004403 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 391595004404 nucleotide binding site [chemical binding]; other site 391595004405 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 391595004406 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 391595004407 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391595004408 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595004409 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 391595004410 Walker A/P-loop; other site 391595004411 ATP binding site [chemical binding]; other site 391595004412 Q-loop/lid; other site 391595004413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595004414 ABC transporter signature motif; other site 391595004415 Walker B; other site 391595004416 D-loop; other site 391595004417 H-loop/switch region; other site 391595004418 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391595004419 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595004420 ligand binding site [chemical binding]; other site 391595004421 flexible hinge region; other site 391595004422 trigger factor; Provisional; Region: tig; PRK01490 391595004423 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 391595004424 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 391595004425 aquaporin Z; Provisional; Region: PRK05420 391595004426 amphipathic channel; other site 391595004427 Asn-Pro-Ala signature motifs; other site 391595004428 Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053 391595004429 diiron binding motif [ion binding]; other site 391595004430 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 391595004431 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 391595004432 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 391595004433 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 391595004434 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 391595004435 YceI-like domain; Region: YceI; smart00867 391595004436 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 391595004437 YceI-like domain; Region: YceI; smart00867 391595004438 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 391595004439 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391595004440 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 391595004441 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 391595004442 NAD(P) binding site [chemical binding]; other site 391595004443 homotetramer interface [polypeptide binding]; other site 391595004444 homodimer interface [polypeptide binding]; other site 391595004445 active site 391595004446 acyl carrier protein; Provisional; Region: acpP; PRK00982 391595004447 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391595004448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391595004449 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 391595004450 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391595004451 dimer interface [polypeptide binding]; other site 391595004452 active site 391595004453 YceG-like family; Region: YceG; pfam02618 391595004454 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 391595004455 dimerization interface [polypeptide binding]; other site 391595004456 Phage-related protein [Function unknown]; Region: COG4695 391595004457 Phage portal protein; Region: Phage_portal; pfam04860 391595004458 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 391595004459 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 391595004460 Phage capsid family; Region: Phage_capsid; pfam05065 391595004461 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 391595004462 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 391595004463 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 391595004464 oligomerization interface [polypeptide binding]; other site 391595004465 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 391595004466 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 391595004467 Phage major tail protein 2; Region: Phage_tail_2; cl11463 391595004468 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 391595004469 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550 391595004470 Phage-related minor tail protein [Function unknown]; Region: COG5281 391595004471 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 391595004472 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 391595004473 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 391595004474 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 391595004475 NlpC/P60 family; Region: NLPC_P60; cl17555 391595004476 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 391595004477 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 391595004478 Putative phage tail protein; Region: Phage-tail_3; pfam13550 391595004479 serine acetyltransferase; Provisional; Region: cysE; PRK11132 391595004480 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 391595004481 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 391595004482 trimer interface [polypeptide binding]; other site 391595004483 active site 391595004484 substrate binding site [chemical binding]; other site 391595004485 CoA binding site [chemical binding]; other site 391595004486 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 391595004487 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391595004488 E3 interaction surface; other site 391595004489 lipoyl attachment site [posttranslational modification]; other site 391595004490 e3 binding domain; Region: E3_binding; pfam02817 391595004491 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391595004492 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 391595004493 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391595004494 E3 interaction surface; other site 391595004495 lipoyl attachment site [posttranslational modification]; other site 391595004496 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391595004497 alpha subunit interface [polypeptide binding]; other site 391595004498 TPP binding site [chemical binding]; other site 391595004499 heterodimer interface [polypeptide binding]; other site 391595004500 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391595004501 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 391595004502 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391595004503 tetramer interface [polypeptide binding]; other site 391595004504 TPP-binding site [chemical binding]; other site 391595004505 heterodimer interface [polypeptide binding]; other site 391595004506 phosphorylation loop region [posttranslational modification] 391595004507 Septum formation initiator; Region: DivIC; cl17659 391595004508 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 391595004509 Phosphoglycerate kinase; Region: PGK; pfam00162 391595004510 substrate binding site [chemical binding]; other site 391595004511 hinge regions; other site 391595004512 ADP binding site [chemical binding]; other site 391595004513 catalytic site [active] 391595004514 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 391595004515 active site 391595004516 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 391595004517 active site 391595004518 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 391595004519 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391595004520 Peptidase family M23; Region: Peptidase_M23; pfam01551 391595004521 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 391595004522 dinuclear metal binding motif [ion binding]; other site 391595004523 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 391595004524 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 391595004525 catalytic triad [active] 391595004526 Protein of unknown function; Region: DUF3971; pfam13116 391595004527 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 391595004528 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 391595004529 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 391595004530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595004531 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391595004532 putative substrate translocation pore; other site 391595004533 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 391595004534 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 391595004535 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595004536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391595004537 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391595004538 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 391595004539 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 391595004540 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 391595004541 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 391595004542 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 391595004543 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 391595004544 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391595004545 substrate binding site [chemical binding]; other site 391595004546 oxyanion hole (OAH) forming residues; other site 391595004547 trimer interface [polypeptide binding]; other site 391595004548 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 391595004549 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 391595004550 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391595004551 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 391595004552 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 391595004553 tetrameric interface [polypeptide binding]; other site 391595004554 NAD binding site [chemical binding]; other site 391595004555 catalytic residues [active] 391595004556 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595004557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595004558 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391595004559 dimerization interface [polypeptide binding]; other site 391595004560 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 391595004561 FOG: CBS domain [General function prediction only]; Region: COG0517 391595004562 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 391595004563 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 391595004564 active site 391595004565 (T/H)XGH motif; other site 391595004566 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 391595004567 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 391595004568 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391595004569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 391595004570 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 391595004571 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 391595004572 TPP-binding site [chemical binding]; other site 391595004573 dimer interface [polypeptide binding]; other site 391595004574 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391595004575 PYR/PP interface [polypeptide binding]; other site 391595004576 dimer interface [polypeptide binding]; other site 391595004577 TPP binding site [chemical binding]; other site 391595004578 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391595004579 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 391595004580 Cell division protein ZapA; Region: ZapA; pfam05164 391595004581 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 391595004582 putative GSH binding site [chemical binding]; other site 391595004583 catalytic residues [active] 391595004584 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 391595004585 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 391595004586 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391595004587 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391595004588 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 391595004589 putative MPT binding site; other site 391595004590 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391595004591 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 391595004592 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391595004593 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391595004594 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391595004595 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391595004596 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 391595004597 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 391595004598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 391595004599 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 391595004600 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 391595004601 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 391595004602 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391595004603 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 391595004604 FAD binding pocket [chemical binding]; other site 391595004605 FAD binding motif [chemical binding]; other site 391595004606 phosphate binding motif [ion binding]; other site 391595004607 beta-alpha-beta structure motif; other site 391595004608 NAD binding pocket [chemical binding]; other site 391595004609 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 391595004610 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 391595004611 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 391595004612 Active Sites [active] 391595004613 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 391595004614 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391595004615 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391595004616 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 391595004617 siroheme synthase; Provisional; Region: cysG; PRK10637 391595004618 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 391595004619 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 391595004620 active site 391595004621 SAM binding site [chemical binding]; other site 391595004622 homodimer interface [polypeptide binding]; other site 391595004623 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595004624 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595004625 putative DNA binding site [nucleotide binding]; other site 391595004626 putative Zn2+ binding site [ion binding]; other site 391595004627 AsnC family; Region: AsnC_trans_reg; pfam01037 391595004628 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391595004629 Cytochrome P450; Region: p450; cl12078 391595004630 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 391595004631 triosephosphate isomerase; Provisional; Region: PRK14565 391595004632 substrate binding site [chemical binding]; other site 391595004633 dimer interface [polypeptide binding]; other site 391595004634 catalytic triad [active] 391595004635 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 391595004636 maltose O-acetyltransferase; Provisional; Region: PRK10092 391595004637 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 391595004638 active site 391595004639 substrate binding site [chemical binding]; other site 391595004640 trimer interface [polypeptide binding]; other site 391595004641 CoA binding site [chemical binding]; other site 391595004642 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 391595004643 Uncharacterized conserved protein [Function unknown]; Region: COG1479 391595004644 Protein of unknown function DUF262; Region: DUF262; pfam03235 391595004645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391595004646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595004647 putative substrate translocation pore; other site 391595004648 Right handed beta helix region; Region: Beta_helix; pfam13229 391595004649 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 391595004650 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 391595004651 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391595004652 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 391595004653 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 391595004654 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 391595004655 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 391595004656 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391595004657 putative CheW interface [polypeptide binding]; other site 391595004658 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 391595004659 Found in ATP-dependent protease La (LON); Region: LON; smart00464 391595004660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595004661 Walker A motif; other site 391595004662 ATP binding site [chemical binding]; other site 391595004663 Walker B motif; other site 391595004664 arginine finger; other site 391595004665 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 391595004666 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391595004667 Transposase; Region: HTH_Tnp_1; cl17663 391595004668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391595004669 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391595004670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391595004671 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391595004672 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391595004673 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391595004674 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 391595004675 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391595004676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391595004677 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391595004678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595004679 active site 391595004680 phosphorylation site [posttranslational modification] 391595004681 intermolecular recognition site; other site 391595004682 dimerization interface [polypeptide binding]; other site 391595004683 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391595004684 DNA binding site [nucleotide binding] 391595004685 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 391595004686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391595004687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595004688 dimer interface [polypeptide binding]; other site 391595004689 phosphorylation site [posttranslational modification] 391595004690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595004691 ATP binding site [chemical binding]; other site 391595004692 Mg2+ binding site [ion binding]; other site 391595004693 G-X-G motif; other site 391595004694 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391595004695 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 391595004696 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 391595004697 dimer interface [polypeptide binding]; other site 391595004698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595004699 catalytic residue [active] 391595004700 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391595004701 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595004702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595004703 putative PBP binding loops; other site 391595004704 dimer interface [polypeptide binding]; other site 391595004705 ABC-ATPase subunit interface; other site 391595004706 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595004707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595004708 dimer interface [polypeptide binding]; other site 391595004709 conserved gate region; other site 391595004710 putative PBP binding loops; other site 391595004711 ABC-ATPase subunit interface; other site 391595004712 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391595004713 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391595004714 Walker A/P-loop; other site 391595004715 ATP binding site [chemical binding]; other site 391595004716 Q-loop/lid; other site 391595004717 ABC transporter signature motif; other site 391595004718 Walker B; other site 391595004719 D-loop; other site 391595004720 H-loop/switch region; other site 391595004721 TOBE domain; Region: TOBE_2; pfam08402 391595004722 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595004723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595004724 dimer interface [polypeptide binding]; other site 391595004725 conserved gate region; other site 391595004726 putative PBP binding loops; other site 391595004727 ABC-ATPase subunit interface; other site 391595004728 glucuronate isomerase; Reviewed; Region: PRK02925 391595004729 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 391595004730 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 391595004731 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 391595004732 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 391595004733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595004734 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391595004735 Walker A/P-loop; other site 391595004736 ATP binding site [chemical binding]; other site 391595004737 Q-loop/lid; other site 391595004738 ABC transporter signature motif; other site 391595004739 Walker B; other site 391595004740 D-loop; other site 391595004741 H-loop/switch region; other site 391595004742 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391595004743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595004744 dimer interface [polypeptide binding]; other site 391595004745 conserved gate region; other site 391595004746 putative PBP binding loops; other site 391595004747 ABC-ATPase subunit interface; other site 391595004748 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 391595004749 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391595004750 Patatin-like phospholipase; Region: Patatin; pfam01734 391595004751 active site 391595004752 nucleophile elbow; other site 391595004753 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 391595004754 Double zinc ribbon; Region: DZR; pfam12773 391595004755 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 391595004756 cyclase homology domain; Region: CHD; cd07302 391595004757 nucleotidyl binding site; other site 391595004758 metal binding site [ion binding]; metal-binding site 391595004759 dimer interface [polypeptide binding]; other site 391595004760 AAA ATPase domain; Region: AAA_16; pfam13191 391595004761 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391595004762 tetramer interface [polypeptide binding]; other site 391595004763 TPP-binding site [chemical binding]; other site 391595004764 heterodimer interface [polypeptide binding]; other site 391595004765 phosphorylation loop region [posttranslational modification] 391595004766 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391595004767 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391595004768 alpha subunit interface [polypeptide binding]; other site 391595004769 TPP binding site [chemical binding]; other site 391595004770 heterodimer interface [polypeptide binding]; other site 391595004771 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391595004772 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391595004773 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 391595004774 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391595004775 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391595004776 DNA binding site [nucleotide binding] 391595004777 domain linker motif; other site 391595004778 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 391595004779 putative dimerization interface [polypeptide binding]; other site 391595004780 putative ligand binding site [chemical binding]; other site 391595004781 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 391595004782 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391595004783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391595004784 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 391595004785 putative catalytic cysteine [active] 391595004786 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391595004787 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 391595004788 acyl-activating enzyme (AAE) consensus motif; other site 391595004789 putative AMP binding site [chemical binding]; other site 391595004790 putative active site [active] 391595004791 putative CoA binding site [chemical binding]; other site 391595004792 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 391595004793 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 391595004794 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595004795 Walker A/P-loop; other site 391595004796 ATP binding site [chemical binding]; other site 391595004797 Q-loop/lid; other site 391595004798 ABC transporter signature motif; other site 391595004799 Walker B; other site 391595004800 D-loop; other site 391595004801 H-loop/switch region; other site 391595004802 TOBE domain; Region: TOBE; cl01440 391595004803 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 391595004804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595004805 dimer interface [polypeptide binding]; other site 391595004806 conserved gate region; other site 391595004807 putative PBP binding loops; other site 391595004808 ABC-ATPase subunit interface; other site 391595004809 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 391595004810 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391595004811 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391595004812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595004813 dimer interface [polypeptide binding]; other site 391595004814 conserved gate region; other site 391595004815 putative PBP binding loops; other site 391595004816 ABC-ATPase subunit interface; other site 391595004817 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391595004818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595004819 Walker A/P-loop; other site 391595004820 ATP binding site [chemical binding]; other site 391595004821 Q-loop/lid; other site 391595004822 ABC transporter signature motif; other site 391595004823 Walker B; other site 391595004824 D-loop; other site 391595004825 H-loop/switch region; other site 391595004826 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 391595004827 PBP superfamily domain; Region: PBP_like_2; pfam12849 391595004828 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 391595004829 Domain of unknown function DUF59; Region: DUF59; pfam01883 391595004830 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 391595004831 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 391595004832 Walker A motif; other site 391595004833 Cytochrome c; Region: Cytochrom_C; pfam00034 391595004834 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 391595004835 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391595004836 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 391595004837 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 391595004838 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 391595004839 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 391595004840 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 391595004841 [4Fe-4S] binding site [ion binding]; other site 391595004842 molybdopterin cofactor binding site; other site 391595004843 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391595004844 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 391595004845 molybdopterin cofactor binding site; other site 391595004846 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 391595004847 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 391595004848 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 391595004849 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391595004850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595004851 DNA-binding site [nucleotide binding]; DNA binding site 391595004852 FCD domain; Region: FCD; pfam07729 391595004853 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 391595004854 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391595004855 Bacterial transcriptional regulator; Region: IclR; pfam01614 391595004856 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 391595004857 homodimer interface [polypeptide binding]; other site 391595004858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595004859 catalytic residue [active] 391595004860 serine racemase; Region: PLN02970 391595004861 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391595004862 tetramer interface [polypeptide binding]; other site 391595004863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595004864 catalytic residue [active] 391595004865 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 391595004866 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 391595004867 dimer interface [polypeptide binding]; other site 391595004868 active site 391595004869 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391595004870 substrate binding site [chemical binding]; other site 391595004871 catalytic residue [active] 391595004872 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 391595004873 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391595004874 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 391595004875 Catalytic domain of Protein Kinases; Region: PKc; cd00180 391595004876 active site 391595004877 ATP binding site [chemical binding]; other site 391595004878 substrate binding site [chemical binding]; other site 391595004879 activation loop (A-loop); other site 391595004880 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 391595004881 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 391595004882 phosphopeptide binding site; other site 391595004883 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 391595004884 active site 391595004885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595004886 Walker A/P-loop; other site 391595004887 ATP binding site [chemical binding]; other site 391595004888 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 391595004889 G1 box; other site 391595004890 GTP/Mg2+ binding site [chemical binding]; other site 391595004891 G2 box; other site 391595004892 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 391595004893 G3 box; other site 391595004894 Switch II region; other site 391595004895 GTP/Mg2+ binding site [chemical binding]; other site 391595004896 G4 box; other site 391595004897 G5 box; other site 391595004898 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 391595004899 G1 box; other site 391595004900 GTP/Mg2+ binding site [chemical binding]; other site 391595004901 G2 box; other site 391595004902 Switch I region; other site 391595004903 G3 box; other site 391595004904 Switch II region; other site 391595004905 G4 box; other site 391595004906 G5 box; other site 391595004907 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391595004908 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 391595004909 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391595004910 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 391595004911 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 391595004912 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 391595004913 N- and C-terminal domain interface [polypeptide binding]; other site 391595004914 active site 391595004915 MgATP binding site [chemical binding]; other site 391595004916 catalytic site [active] 391595004917 metal binding site [ion binding]; metal-binding site 391595004918 glycerol binding site [chemical binding]; other site 391595004919 homotetramer interface [polypeptide binding]; other site 391595004920 homodimer interface [polypeptide binding]; other site 391595004921 FBP binding site [chemical binding]; other site 391595004922 protein IIAGlc interface [polypeptide binding]; other site 391595004923 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 391595004924 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 391595004925 putative active site [active] 391595004926 metal binding site [ion binding]; metal-binding site 391595004927 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 391595004928 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 391595004929 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391595004930 phosphogluconate dehydratase; Validated; Region: PRK09054 391595004931 6-phosphogluconate dehydratase; Region: edd; TIGR01196 391595004932 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 391595004933 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 391595004934 active site 391595004935 intersubunit interface [polypeptide binding]; other site 391595004936 catalytic residue [active] 391595004937 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 391595004938 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391595004939 putative substrate binding site [chemical binding]; other site 391595004940 putative ATP binding site [chemical binding]; other site 391595004941 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 391595004942 homodimer interface [polypeptide binding]; other site 391595004943 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 391595004944 active site pocket [active] 391595004945 glycogen branching enzyme; Provisional; Region: PRK05402 391595004946 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 391595004947 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 391595004948 active site 391595004949 catalytic site [active] 391595004950 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 391595004951 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 391595004952 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 391595004953 ligand binding site; other site 391595004954 oligomer interface; other site 391595004955 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 391595004956 dimer interface [polypeptide binding]; other site 391595004957 N-terminal domain interface [polypeptide binding]; other site 391595004958 sulfate 1 binding site; other site 391595004959 glycogen synthase; Provisional; Region: glgA; PRK00654 391595004960 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 391595004961 ADP-binding pocket [chemical binding]; other site 391595004962 homodimer interface [polypeptide binding]; other site 391595004963 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 391595004964 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 391595004965 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 391595004966 active site 391595004967 catalytic site [active] 391595004968 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 391595004969 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 391595004970 phosphoglucomutase; Region: PLN02307 391595004971 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 391595004972 active site 391595004973 substrate binding site [chemical binding]; other site 391595004974 metal binding site [ion binding]; metal-binding site 391595004975 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 391595004976 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 391595004977 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 391595004978 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391595004979 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 391595004980 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 391595004981 active site 391595004982 intersubunit interface [polypeptide binding]; other site 391595004983 catalytic residue [active] 391595004984 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 391595004985 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 391595004986 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 391595004987 classical (c) SDRs; Region: SDR_c; cd05233 391595004988 NAD(P) binding site [chemical binding]; other site 391595004989 active site 391595004990 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 391595004991 Melibiase; Region: Melibiase; pfam02065 391595004992 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595004993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595004994 dimer interface [polypeptide binding]; other site 391595004995 conserved gate region; other site 391595004996 putative PBP binding loops; other site 391595004997 ABC-ATPase subunit interface; other site 391595004998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595004999 dimer interface [polypeptide binding]; other site 391595005000 conserved gate region; other site 391595005001 putative PBP binding loops; other site 391595005002 ABC-ATPase subunit interface; other site 391595005003 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595005004 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391595005005 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391595005006 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 391595005007 Bacterial transcriptional regulator; Region: IclR; pfam01614 391595005008 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391595005009 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391595005010 Walker A/P-loop; other site 391595005011 ATP binding site [chemical binding]; other site 391595005012 Q-loop/lid; other site 391595005013 ABC transporter signature motif; other site 391595005014 Walker B; other site 391595005015 D-loop; other site 391595005016 H-loop/switch region; other site 391595005017 TOBE domain; Region: TOBE_2; pfam08402 391595005018 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 391595005019 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 391595005020 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 391595005021 oligomer interface [polypeptide binding]; other site 391595005022 active site residues [active] 391595005023 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 391595005024 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 391595005025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595005026 Walker A motif; other site 391595005027 ATP binding site [chemical binding]; other site 391595005028 Walker B motif; other site 391595005029 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 391595005030 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 391595005031 homotrimer interaction site [polypeptide binding]; other site 391595005032 putative active site [active] 391595005033 NADH dehydrogenase; Validated; Region: PRK08183 391595005034 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 391595005035 mce related protein; Region: MCE; pfam02470 391595005036 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 391595005037 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 391595005038 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 391595005039 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391595005040 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 391595005041 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391595005042 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 391595005043 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391595005044 carboxyltransferase (CT) interaction site; other site 391595005045 biotinylation site [posttranslational modification]; other site 391595005046 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391595005047 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391595005048 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 391595005049 acyl-activating enzyme (AAE) consensus motif; other site 391595005050 acyl-activating enzyme (AAE) consensus motif; other site 391595005051 putative AMP binding site [chemical binding]; other site 391595005052 putative active site [active] 391595005053 putative CoA binding site [chemical binding]; other site 391595005054 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391595005055 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391595005056 Walker A/P-loop; other site 391595005057 ATP binding site [chemical binding]; other site 391595005058 Q-loop/lid; other site 391595005059 ABC transporter signature motif; other site 391595005060 Walker B; other site 391595005061 D-loop; other site 391595005062 H-loop/switch region; other site 391595005063 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391595005064 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391595005065 Walker A/P-loop; other site 391595005066 ATP binding site [chemical binding]; other site 391595005067 Q-loop/lid; other site 391595005068 ABC transporter signature motif; other site 391595005069 Walker B; other site 391595005070 D-loop; other site 391595005071 H-loop/switch region; other site 391595005072 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391595005073 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391595005074 TM-ABC transporter signature motif; other site 391595005075 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391595005076 TM-ABC transporter signature motif; other site 391595005077 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391595005078 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 391595005079 putative ligand binding site [chemical binding]; other site 391595005080 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391595005081 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595005082 non-specific DNA binding site [nucleotide binding]; other site 391595005083 salt bridge; other site 391595005084 sequence-specific DNA binding site [nucleotide binding]; other site 391595005085 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 391595005086 Response regulator receiver domain; Region: Response_reg; pfam00072 391595005087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595005088 active site 391595005089 phosphorylation site [posttranslational modification] 391595005090 intermolecular recognition site; other site 391595005091 dimerization interface [polypeptide binding]; other site 391595005092 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 391595005093 Na binding site [ion binding]; other site 391595005094 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 391595005095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595005096 dimer interface [polypeptide binding]; other site 391595005097 phosphorylation site [posttranslational modification] 391595005098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595005099 ATP binding site [chemical binding]; other site 391595005100 Mg2+ binding site [ion binding]; other site 391595005101 G-X-G motif; other site 391595005102 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 391595005103 Putative phosphatase (DUF442); Region: DUF442; cl17385 391595005104 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 391595005105 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391595005106 catalytic core [active] 391595005107 Pirin-related protein [General function prediction only]; Region: COG1741 391595005108 Pirin; Region: Pirin; pfam02678 391595005109 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 391595005110 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391595005111 hypothetical protein; Validated; Region: PRK09104 391595005112 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 391595005113 metal binding site [ion binding]; metal-binding site 391595005114 putative dimer interface [polypeptide binding]; other site 391595005115 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 391595005116 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 391595005117 substrate-cofactor binding pocket; other site 391595005118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595005119 catalytic residue [active] 391595005120 Helix-turn-helix domain; Region: HTH_25; pfam13413 391595005121 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 391595005122 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 391595005123 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 391595005124 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 391595005125 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 391595005126 catalytic residues [active] 391595005127 Peptidase family M48; Region: Peptidase_M48; cl12018 391595005128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595005129 TPR repeat; Region: TPR_11; pfam13414 391595005130 binding surface 391595005131 TPR motif; other site 391595005132 Tetratricopeptide repeat; Region: TPR_16; pfam13432 391595005133 hypothetical protein; Provisional; Region: PRK08960 391595005134 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391595005135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595005136 homodimer interface [polypeptide binding]; other site 391595005137 catalytic residue [active] 391595005138 AMIN domain; Region: AMIN; pfam11741 391595005139 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 391595005140 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 391595005141 active site 391595005142 metal binding site [ion binding]; metal-binding site 391595005143 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 391595005144 Transglycosylase; Region: Transgly; pfam00912 391595005145 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 391595005146 peptide chain release factor 2; Validated; Region: prfB; PRK00578 391595005147 This domain is found in peptide chain release factors; Region: PCRF; smart00937 391595005148 RF-1 domain; Region: RF-1; pfam00472 391595005149 Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955 391595005150 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391595005151 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 391595005152 [2Fe-2S] cluster binding site [ion binding]; other site 391595005153 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 391595005154 alpha subunit interface [polypeptide binding]; other site 391595005155 active site 391595005156 substrate binding site [chemical binding]; other site 391595005157 Fe binding site [ion binding]; other site 391595005158 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391595005159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595005160 sequence-specific DNA binding site [nucleotide binding]; other site 391595005161 salt bridge; other site 391595005162 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 391595005163 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 391595005164 putative valine binding site [chemical binding]; other site 391595005165 dimer interface [polypeptide binding]; other site 391595005166 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 391595005167 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 391595005168 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391595005169 PYR/PP interface [polypeptide binding]; other site 391595005170 dimer interface [polypeptide binding]; other site 391595005171 TPP binding site [chemical binding]; other site 391595005172 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391595005173 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 391595005174 TPP-binding site [chemical binding]; other site 391595005175 dimer interface [polypeptide binding]; other site 391595005176 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391595005177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595005178 active site 391595005179 phosphorylation site [posttranslational modification] 391595005180 intermolecular recognition site; other site 391595005181 dimerization interface [polypeptide binding]; other site 391595005182 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391595005183 DNA binding residues [nucleotide binding] 391595005184 dimerization interface [polypeptide binding]; other site 391595005185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 391595005186 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 391595005187 Histidine kinase; Region: HisKA_3; pfam07730 391595005188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595005189 ATP binding site [chemical binding]; other site 391595005190 Mg2+ binding site [ion binding]; other site 391595005191 G-X-G motif; other site 391595005192 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 391595005193 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595005194 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391595005195 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391595005196 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391595005197 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 391595005198 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 391595005199 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 391595005200 RDD family; Region: RDD; pfam06271 391595005201 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 391595005202 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 391595005203 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391595005204 metal binding triad; other site 391595005205 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391595005206 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391595005207 metal binding triad; other site 391595005208 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 391595005209 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 391595005210 putative RNA binding site [nucleotide binding]; other site 391595005211 Methyltransferase domain; Region: Methyltransf_26; pfam13659 391595005212 PIN domain; Region: PIN_3; pfam13470 391595005213 Peptidase family M48; Region: Peptidase_M48; cl12018 391595005214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 391595005215 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391595005216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391595005217 Coenzyme A binding pocket [chemical binding]; other site 391595005218 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391595005219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595005220 Walker A motif; other site 391595005221 ATP binding site [chemical binding]; other site 391595005222 Walker B motif; other site 391595005223 arginine finger; other site 391595005224 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 391595005225 salicylate hydroxylase; Provisional; Region: PRK08163 391595005226 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391595005227 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 391595005228 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 391595005229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595005230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595005231 WHG domain; Region: WHG; pfam13305 391595005232 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 391595005233 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391595005234 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 391595005235 catalytic site [active] 391595005236 Homoserine O-succinyltransferase; Region: HTS; pfam04204 391595005237 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 391595005238 proposed active site lysine [active] 391595005239 conserved cys residue [active] 391595005240 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595005241 EamA-like transporter family; Region: EamA; pfam00892 391595005242 EamA-like transporter family; Region: EamA; pfam00892 391595005243 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 391595005244 EamA-like transporter family; Region: EamA; pfam00892 391595005245 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391595005246 BCCT family transporter; Region: BCCT; cl00569 391595005247 TetR family transcriptional regulator; Provisional; Region: PRK14996 391595005248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595005249 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 391595005250 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 391595005251 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391595005252 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391595005253 Serine hydrolase; Region: Ser_hydrolase; cl17834 391595005254 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 391595005255 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 391595005256 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391595005257 Lipase (class 2); Region: Lipase_2; pfam01674 391595005258 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391595005259 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 391595005260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595005261 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 391595005262 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 391595005263 trimer interface [polypeptide binding]; other site 391595005264 active site 391595005265 substrate binding site [chemical binding]; other site 391595005266 CoA binding site [chemical binding]; other site 391595005267 SnoaL-like domain; Region: SnoaL_2; pfam12680 391595005268 Isochorismatase family; Region: Isochorismatase; pfam00857 391595005269 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 391595005270 catalytic triad [active] 391595005271 conserved cis-peptide bond; other site 391595005272 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391595005273 MarR family; Region: MarR_2; pfam12802 391595005274 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 391595005275 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595005276 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595005277 active site 391595005278 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391595005279 active site 391595005280 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 391595005281 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391595005282 Walker A/P-loop; other site 391595005283 ATP binding site [chemical binding]; other site 391595005284 Q-loop/lid; other site 391595005285 ABC transporter signature motif; other site 391595005286 Walker B; other site 391595005287 D-loop; other site 391595005288 H-loop/switch region; other site 391595005289 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 391595005290 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595005291 Walker A/P-loop; other site 391595005292 ATP binding site [chemical binding]; other site 391595005293 Q-loop/lid; other site 391595005294 ABC transporter signature motif; other site 391595005295 Walker B; other site 391595005296 D-loop; other site 391595005297 H-loop/switch region; other site 391595005298 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391595005299 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 391595005300 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 391595005301 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 391595005302 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 391595005303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595005304 DNA-binding site [nucleotide binding]; DNA binding site 391595005305 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 391595005306 UTRA domain; Region: UTRA; pfam07702 391595005307 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595005308 dimerization interface [polypeptide binding]; other site 391595005309 putative DNA binding site [nucleotide binding]; other site 391595005310 putative Zn2+ binding site [ion binding]; other site 391595005311 Low molecular weight phosphatase family; Region: LMWPc; cd00115 391595005312 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 391595005313 active site 391595005314 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 391595005315 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 391595005316 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391595005317 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 391595005318 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 391595005319 trimer interface [polypeptide binding]; other site 391595005320 active site 391595005321 substrate binding site [chemical binding]; other site 391595005322 CoA binding site [chemical binding]; other site 391595005323 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 391595005324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595005325 dimer interface [polypeptide binding]; other site 391595005326 conserved gate region; other site 391595005327 ABC-ATPase subunit interface; other site 391595005328 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 391595005329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595005330 dimer interface [polypeptide binding]; other site 391595005331 conserved gate region; other site 391595005332 putative PBP binding loops; other site 391595005333 ABC-ATPase subunit interface; other site 391595005334 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 391595005335 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 391595005336 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 391595005337 Walker A/P-loop; other site 391595005338 ATP binding site [chemical binding]; other site 391595005339 Q-loop/lid; other site 391595005340 ABC transporter signature motif; other site 391595005341 Walker B; other site 391595005342 D-loop; other site 391595005343 H-loop/switch region; other site 391595005344 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 391595005345 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 391595005346 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 391595005347 dihydropyrimidinase; Provisional; Region: PRK13404 391595005348 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 391595005349 tetramer interface [polypeptide binding]; other site 391595005350 active site 391595005351 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391595005352 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391595005353 Amidase; Region: Amidase; cl11426 391595005354 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595005355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595005356 dimer interface [polypeptide binding]; other site 391595005357 conserved gate region; other site 391595005358 putative PBP binding loops; other site 391595005359 ABC-ATPase subunit interface; other site 391595005360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595005361 dimer interface [polypeptide binding]; other site 391595005362 conserved gate region; other site 391595005363 putative PBP binding loops; other site 391595005364 ABC-ATPase subunit interface; other site 391595005365 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595005366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595005367 Walker A/P-loop; other site 391595005368 ATP binding site [chemical binding]; other site 391595005369 Q-loop/lid; other site 391595005370 ABC transporter signature motif; other site 391595005371 Walker B; other site 391595005372 D-loop; other site 391595005373 H-loop/switch region; other site 391595005374 TOBE domain; Region: TOBE_2; pfam08402 391595005375 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227 391595005376 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 391595005377 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391595005378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595005379 DNA-binding site [nucleotide binding]; DNA binding site 391595005380 FCD domain; Region: FCD; pfam07729 391595005381 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595005382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595005383 dimer interface [polypeptide binding]; other site 391595005384 conserved gate region; other site 391595005385 putative PBP binding loops; other site 391595005386 ABC-ATPase subunit interface; other site 391595005387 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595005388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595005389 dimer interface [polypeptide binding]; other site 391595005390 putative PBP binding loops; other site 391595005391 ABC-ATPase subunit interface; other site 391595005392 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595005393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595005394 Walker A/P-loop; other site 391595005395 ATP binding site [chemical binding]; other site 391595005396 Q-loop/lid; other site 391595005397 ABC transporter signature motif; other site 391595005398 Walker B; other site 391595005399 D-loop; other site 391595005400 H-loop/switch region; other site 391595005401 TOBE domain; Region: TOBE_2; pfam08402 391595005402 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391595005403 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391595005404 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391595005405 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 391595005406 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391595005407 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 391595005408 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 391595005409 dimer interface [polypeptide binding]; other site 391595005410 active site 391595005411 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 391595005412 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391595005413 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 391595005414 ATP binding site [chemical binding]; other site 391595005415 substrate binding site [chemical binding]; other site 391595005416 BtpA family; Region: BtpA; cl00440 391595005417 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 391595005418 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 391595005419 active site 391595005420 catalytic site [active] 391595005421 tetramer interface [polypeptide binding]; other site 391595005422 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 391595005423 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391595005424 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 391595005425 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595005426 active site 391595005427 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595005428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595005429 Walker A/P-loop; other site 391595005430 ATP binding site [chemical binding]; other site 391595005431 Q-loop/lid; other site 391595005432 ABC transporter signature motif; other site 391595005433 Walker B; other site 391595005434 D-loop; other site 391595005435 H-loop/switch region; other site 391595005436 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391595005437 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391595005438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391595005439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595005440 ABC-ATPase subunit interface; other site 391595005441 putative PBP binding loops; other site 391595005442 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595005443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595005444 dimer interface [polypeptide binding]; other site 391595005445 conserved gate region; other site 391595005446 putative PBP binding loops; other site 391595005447 ABC-ATPase subunit interface; other site 391595005448 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 391595005449 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 391595005450 active site 391595005451 catalytic site [active] 391595005452 tetramer interface [polypeptide binding]; other site 391595005453 NHL repeat; Region: NHL; pfam01436 391595005454 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391595005455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595005456 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595005457 dimerization interface [polypeptide binding]; other site 391595005458 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 391595005459 Fatty acid desaturase; Region: FA_desaturase; pfam00487 391595005460 putative di-iron ligands [ion binding]; other site 391595005461 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391595005462 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595005463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595005464 Walker A/P-loop; other site 391595005465 ATP binding site [chemical binding]; other site 391595005466 Q-loop/lid; other site 391595005467 ABC transporter signature motif; other site 391595005468 Walker B; other site 391595005469 D-loop; other site 391595005470 H-loop/switch region; other site 391595005471 TOBE domain; Region: TOBE_2; pfam08402 391595005472 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391595005473 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391595005474 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 391595005475 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595005476 dimer interface [polypeptide binding]; other site 391595005477 conserved gate region; other site 391595005478 putative PBP binding loops; other site 391595005479 ABC-ATPase subunit interface; other site 391595005480 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595005481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595005482 dimer interface [polypeptide binding]; other site 391595005483 conserved gate region; other site 391595005484 putative PBP binding loops; other site 391595005485 ABC-ATPase subunit interface; other site 391595005486 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 391595005487 agmatinase; Region: agmatinase; TIGR01230 391595005488 oligomer interface [polypeptide binding]; other site 391595005489 putative active site [active] 391595005490 Mn binding site [ion binding]; other site 391595005491 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391595005492 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 391595005493 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 391595005494 acyl-activating enzyme (AAE) consensus motif; other site 391595005495 acyl-activating enzyme (AAE) consensus motif; other site 391595005496 putative AMP binding site [chemical binding]; other site 391595005497 putative active site [active] 391595005498 putative CoA binding site [chemical binding]; other site 391595005499 CoA binding site [chemical binding]; other site 391595005500 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 391595005501 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391595005502 putative NAD(P) binding site [chemical binding]; other site 391595005503 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391595005504 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 391595005505 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 391595005506 active site 391595005507 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391595005508 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391595005509 TM-ABC transporter signature motif; other site 391595005510 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595005511 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391595005512 TM-ABC transporter signature motif; other site 391595005513 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391595005514 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 391595005515 putative ligand binding site [chemical binding]; other site 391595005516 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391595005517 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391595005518 Walker A/P-loop; other site 391595005519 ATP binding site [chemical binding]; other site 391595005520 Q-loop/lid; other site 391595005521 ABC transporter signature motif; other site 391595005522 Walker B; other site 391595005523 D-loop; other site 391595005524 H-loop/switch region; other site 391595005525 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391595005526 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391595005527 Walker A/P-loop; other site 391595005528 ATP binding site [chemical binding]; other site 391595005529 Q-loop/lid; other site 391595005530 ABC transporter signature motif; other site 391595005531 Walker B; other site 391595005532 D-loop; other site 391595005533 H-loop/switch region; other site 391595005534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595005535 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391595005536 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595005537 dimerization interface [polypeptide binding]; other site 391595005538 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 391595005539 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 391595005540 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 391595005541 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 391595005542 LytTr DNA-binding domain; Region: LytTR; smart00850 391595005543 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 391595005544 FAD binding domain; Region: FAD_binding_4; pfam01565 391595005545 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 391595005546 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391595005547 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391595005548 catalytic loop [active] 391595005549 iron binding site [ion binding]; other site 391595005550 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391595005551 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 391595005552 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 391595005553 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391595005554 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391595005555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595005556 Walker A motif; other site 391595005557 ATP binding site [chemical binding]; other site 391595005558 Walker B motif; other site 391595005559 arginine finger; other site 391595005560 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 391595005561 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 391595005562 metal ion-dependent adhesion site (MIDAS); other site 391595005563 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391595005564 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391595005565 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 391595005566 Ligand binding site; other site 391595005567 metal-binding site 391595005568 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 391595005569 putative hydrophobic ligand binding site [chemical binding]; other site 391595005570 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391595005571 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391595005572 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 391595005573 Helix-turn-helix domain; Region: HTH_38; pfam13936 391595005574 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391595005575 Homeodomain-like domain; Region: HTH_32; pfam13565 391595005576 Integrase core domain; Region: rve; pfam00665 391595005577 Response regulator receiver domain; Region: Response_reg; pfam00072 391595005578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595005579 active site 391595005580 phosphorylation site [posttranslational modification] 391595005581 intermolecular recognition site; other site 391595005582 dimerization interface [polypeptide binding]; other site 391595005583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391595005584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595005585 dimer interface [polypeptide binding]; other site 391595005586 phosphorylation site [posttranslational modification] 391595005587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595005588 ATP binding site [chemical binding]; other site 391595005589 Mg2+ binding site [ion binding]; other site 391595005590 G-X-G motif; other site 391595005591 Response regulator receiver domain; Region: Response_reg; pfam00072 391595005592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595005593 active site 391595005594 phosphorylation site [posttranslational modification] 391595005595 intermolecular recognition site; other site 391595005596 dimerization interface [polypeptide binding]; other site 391595005597 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391595005598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595005599 active site 391595005600 phosphorylation site [posttranslational modification] 391595005601 intermolecular recognition site; other site 391595005602 dimerization interface [polypeptide binding]; other site 391595005603 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391595005604 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595005605 dimer interface [polypeptide binding]; other site 391595005606 phosphorylation site [posttranslational modification] 391595005607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595005608 ATP binding site [chemical binding]; other site 391595005609 Mg2+ binding site [ion binding]; other site 391595005610 G-X-G motif; other site 391595005611 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391595005612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595005613 active site 391595005614 phosphorylation site [posttranslational modification] 391595005615 intermolecular recognition site; other site 391595005616 dimerization interface [polypeptide binding]; other site 391595005617 multiple promoter invertase; Provisional; Region: mpi; PRK13413 391595005618 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391595005619 catalytic residues [active] 391595005620 catalytic nucleophile [active] 391595005621 Presynaptic Site I dimer interface [polypeptide binding]; other site 391595005622 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391595005623 Synaptic Flat tetramer interface [polypeptide binding]; other site 391595005624 Synaptic Site I dimer interface [polypeptide binding]; other site 391595005625 DNA binding site [nucleotide binding] 391595005626 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391595005627 DNA-binding interface [nucleotide binding]; DNA binding site 391595005628 mitochondrial import inner membrane, translocase subunit; Region: 3a0801s03tim44; TIGR00984 391595005629 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391595005630 ligand binding site [chemical binding]; other site 391595005631 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 391595005632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391595005633 ATP binding site [chemical binding]; other site 391595005634 putative Mg++ binding site [ion binding]; other site 391595005635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391595005636 nucleotide binding region [chemical binding]; other site 391595005637 ATP-binding site [chemical binding]; other site 391595005638 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 391595005639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391595005640 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391595005641 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391595005642 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391595005643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391595005644 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391595005645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391595005646 Transposase; Region: HTH_Tnp_1; cl17663 391595005647 GMP synthase; Reviewed; Region: guaA; PRK00074 391595005648 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 391595005649 AMP/PPi binding site [chemical binding]; other site 391595005650 candidate oxyanion hole; other site 391595005651 catalytic triad [active] 391595005652 potential glutamine specificity residues [chemical binding]; other site 391595005653 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 391595005654 ATP Binding subdomain [chemical binding]; other site 391595005655 Ligand Binding sites [chemical binding]; other site 391595005656 Dimerization subdomain; other site 391595005657 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 391595005658 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055 391595005659 DnaA box-binding interface [nucleotide binding]; other site 391595005660 lipoyl synthase; Provisional; Region: PRK05481 391595005661 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595005662 FeS/SAM binding site; other site 391595005663 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391595005664 active site 391595005665 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 391595005666 putative coenzyme Q binding site [chemical binding]; other site 391595005667 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 391595005668 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 391595005669 tetramer interfaces [polypeptide binding]; other site 391595005670 binuclear metal-binding site [ion binding]; other site 391595005671 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 391595005672 homotrimer interaction site [polypeptide binding]; other site 391595005673 zinc binding site [ion binding]; other site 391595005674 CDP-binding sites; other site 391595005675 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 391595005676 substrate binding site; other site 391595005677 dimer interface; other site 391595005678 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 391595005679 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 391595005680 FMN binding site [chemical binding]; other site 391595005681 active site 391595005682 catalytic residues [active] 391595005683 substrate binding site [chemical binding]; other site 391595005684 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 391595005685 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 391595005686 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595005687 dimer interface [polypeptide binding]; other site 391595005688 phosphorylation site [posttranslational modification] 391595005689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595005690 ATP binding site [chemical binding]; other site 391595005691 G-X-G motif; other site 391595005692 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391595005693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595005694 active site 391595005695 phosphorylation site [posttranslational modification] 391595005696 intermolecular recognition site; other site 391595005697 dimerization interface [polypeptide binding]; other site 391595005698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595005699 Walker A motif; other site 391595005700 ATP binding site [chemical binding]; other site 391595005701 Walker B motif; other site 391595005702 arginine finger; other site 391595005703 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 391595005704 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 391595005705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391595005706 dimerization interface [polypeptide binding]; other site 391595005707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595005708 dimer interface [polypeptide binding]; other site 391595005709 phosphorylation site [posttranslational modification] 391595005710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595005711 ATP binding site [chemical binding]; other site 391595005712 Mg2+ binding site [ion binding]; other site 391595005713 G-X-G motif; other site 391595005714 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391595005715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595005716 active site 391595005717 phosphorylation site [posttranslational modification] 391595005718 intermolecular recognition site; other site 391595005719 dimerization interface [polypeptide binding]; other site 391595005720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595005721 Walker A motif; other site 391595005722 ATP binding site [chemical binding]; other site 391595005723 Walker B motif; other site 391595005724 arginine finger; other site 391595005725 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 391595005726 SnoaL-like domain; Region: SnoaL_2; pfam12680 391595005727 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391595005728 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 391595005729 TrkA-N domain; Region: TrkA_N; pfam02254 391595005730 TrkA-C domain; Region: TrkA_C; pfam02080 391595005731 TrkA-N domain; Region: TrkA_N; pfam02254 391595005732 TrkA-C domain; Region: TrkA_C; pfam02080 391595005733 Cation transport protein; Region: TrkH; cl17365 391595005734 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 391595005735 bacterial Hfq-like; Region: Hfq; cd01716 391595005736 hexamer interface [polypeptide binding]; other site 391595005737 Sm1 motif; other site 391595005738 RNA binding site [nucleotide binding]; other site 391595005739 Sm2 motif; other site 391595005740 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 391595005741 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 391595005742 HflX GTPase family; Region: HflX; cd01878 391595005743 G1 box; other site 391595005744 GTP/Mg2+ binding site [chemical binding]; other site 391595005745 Switch I region; other site 391595005746 G2 box; other site 391595005747 G3 box; other site 391595005748 Switch II region; other site 391595005749 G4 box; other site 391595005750 G5 box; other site 391595005751 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 391595005752 pseudouridine synthase; Region: TIGR00093 391595005753 active site 391595005754 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 391595005755 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 391595005756 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 391595005757 active site 391595005758 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391595005759 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391595005760 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 391595005761 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 391595005762 dimer interface [polypeptide binding]; other site 391595005763 allosteric magnesium binding site [ion binding]; other site 391595005764 active site 391595005765 aspartate-rich active site metal binding site; other site 391595005766 Schiff base residues; other site 391595005767 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 391595005768 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 391595005769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391595005770 ATP binding site [chemical binding]; other site 391595005771 putative Mg++ binding site [ion binding]; other site 391595005772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391595005773 nucleotide binding region [chemical binding]; other site 391595005774 ATP-binding site [chemical binding]; other site 391595005775 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 391595005776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595005777 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 391595005778 putative substrate translocation pore; other site 391595005779 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 391595005780 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 391595005781 catalytic residues [active] 391595005782 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391595005783 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391595005784 acyl-activating enzyme (AAE) consensus motif; other site 391595005785 AMP binding site [chemical binding]; other site 391595005786 active site 391595005787 CoA binding site [chemical binding]; other site 391595005788 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391595005789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595005790 non-specific DNA binding site [nucleotide binding]; other site 391595005791 salt bridge; other site 391595005792 sequence-specific DNA binding site [nucleotide binding]; other site 391595005793 Cupin domain; Region: Cupin_2; pfam07883 391595005794 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 391595005795 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 391595005796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595005797 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 391595005798 NAD(P) binding site [chemical binding]; other site 391595005799 active site 391595005800 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 391595005801 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 391595005802 active site 391595005803 nucleophile elbow; other site 391595005804 Uncharacterized conserved protein [Function unknown]; Region: COG2928 391595005805 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 391595005806 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391595005807 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 391595005808 substrate binding site [chemical binding]; other site 391595005809 ATP binding site [chemical binding]; other site 391595005810 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 391595005811 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 391595005812 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391595005813 thiamine phosphate binding site [chemical binding]; other site 391595005814 active site 391595005815 pyrophosphate binding site [ion binding]; other site 391595005816 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 391595005817 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 391595005818 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 391595005819 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 391595005820 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 391595005821 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 391595005822 active site 391595005823 Zn binding site [ion binding]; other site 391595005824 EF-hand domain pair; Region: EF_hand_5; pfam13499 391595005825 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 391595005826 Ca2+ binding site [ion binding]; other site 391595005827 DNA gyrase subunit A; Validated; Region: PRK05560 391595005828 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 391595005829 CAP-like domain; other site 391595005830 active site 391595005831 primary dimer interface [polypeptide binding]; other site 391595005832 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391595005833 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391595005834 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391595005835 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391595005836 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391595005837 Usg-like family; Region: Usg; pfam06233 391595005838 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595005839 FeS/SAM binding site; other site 391595005840 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 391595005841 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 391595005842 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 391595005843 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 391595005844 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 391595005845 putative active site [active] 391595005846 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 391595005847 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 391595005848 active site 391595005849 dimer interface [polypeptide binding]; other site 391595005850 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 391595005851 dimer interface [polypeptide binding]; other site 391595005852 active site 391595005853 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391595005854 active site 391595005855 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 391595005856 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391595005857 catalytic loop [active] 391595005858 iron binding site [ion binding]; other site 391595005859 agmatinase; Region: agmatinase; TIGR01230 391595005860 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 391595005861 oligomer interface [polypeptide binding]; other site 391595005862 active site 391595005863 Mn binding site [ion binding]; other site 391595005864 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 391595005865 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391595005866 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 391595005867 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 391595005868 active site 391595005869 16S rRNA methyltransferase B; Provisional; Region: PRK14901 391595005870 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 391595005871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391595005872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595005873 dimer interface [polypeptide binding]; other site 391595005874 phosphorylation site [posttranslational modification] 391595005875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595005876 ATP binding site [chemical binding]; other site 391595005877 Mg2+ binding site [ion binding]; other site 391595005878 G-X-G motif; other site 391595005879 Response regulator receiver domain; Region: Response_reg; pfam00072 391595005880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595005881 active site 391595005882 phosphorylation site [posttranslational modification] 391595005883 intermolecular recognition site; other site 391595005884 dimerization interface [polypeptide binding]; other site 391595005885 recombinase A; Provisional; Region: recA; PRK09354 391595005886 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 391595005887 hexamer interface [polypeptide binding]; other site 391595005888 Walker A motif; other site 391595005889 ATP binding site [chemical binding]; other site 391595005890 Walker B motif; other site 391595005891 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 391595005892 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 391595005893 motif 1; other site 391595005894 active site 391595005895 motif 2; other site 391595005896 motif 3; other site 391595005897 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 391595005898 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 391595005899 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 391595005900 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 391595005901 G1 box; other site 391595005902 putative GEF interaction site [polypeptide binding]; other site 391595005903 GTP/Mg2+ binding site [chemical binding]; other site 391595005904 Switch I region; other site 391595005905 G2 box; other site 391595005906 G3 box; other site 391595005907 Switch II region; other site 391595005908 G4 box; other site 391595005909 G5 box; other site 391595005910 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 391595005911 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 391595005912 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 391595005913 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595005914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595005915 putative DNA binding site [nucleotide binding]; other site 391595005916 putative Zn2+ binding site [ion binding]; other site 391595005917 AsnC family; Region: AsnC_trans_reg; pfam01037 391595005918 isocitrate dehydrogenase; Validated; Region: PRK08299 391595005919 HD domain; Region: HD_3; pfam13023 391595005920 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 391595005921 Transcriptional regulator; Region: Rrf2; cl17282 391595005922 Rrf2 family protein; Region: rrf2_super; TIGR00738 391595005923 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391595005924 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 391595005925 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595005926 catalytic residue [active] 391595005927 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 391595005928 putative ABC transporter; Region: ycf24; CHL00085 391595005929 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 391595005930 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 391595005931 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 391595005932 Walker A/P-loop; other site 391595005933 ATP binding site [chemical binding]; other site 391595005934 Q-loop/lid; other site 391595005935 ABC transporter signature motif; other site 391595005936 Walker B; other site 391595005937 D-loop; other site 391595005938 H-loop/switch region; other site 391595005939 FeS assembly protein SufD; Region: sufD; TIGR01981 391595005940 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 391595005941 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391595005942 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 391595005943 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595005944 catalytic residue [active] 391595005945 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 391595005946 glutaminase A; Region: Gln_ase; TIGR03814 391595005947 ammonium transporter; Region: amt; TIGR00836 391595005948 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391595005949 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391595005950 metal binding site [ion binding]; metal-binding site 391595005951 active site 391595005952 I-site; other site 391595005953 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391595005954 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 391595005955 Ligand binding site; other site 391595005956 metal-binding site 391595005957 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391595005958 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 391595005959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595005960 Walker A/P-loop; other site 391595005961 ATP binding site [chemical binding]; other site 391595005962 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 391595005963 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 391595005964 putative active site [active] 391595005965 putative metal-binding site [ion binding]; other site 391595005966 Part of AAA domain; Region: AAA_19; pfam13245 391595005967 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 391595005968 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 391595005969 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391595005970 Walker A motif; other site 391595005971 ATP binding site [chemical binding]; other site 391595005972 Walker B motif; other site 391595005973 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 391595005974 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391595005975 multiple promoter invertase; Provisional; Region: mpi; PRK13413 391595005976 catalytic residues [active] 391595005977 catalytic nucleophile [active] 391595005978 Presynaptic Site I dimer interface [polypeptide binding]; other site 391595005979 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391595005980 Synaptic Flat tetramer interface [polypeptide binding]; other site 391595005981 Synaptic Site I dimer interface [polypeptide binding]; other site 391595005982 DNA binding site [nucleotide binding] 391595005983 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391595005984 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 391595005985 DNA methylase; Region: N6_N4_Mtase; cl17433 391595005986 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 391595005987 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 391595005988 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 391595005989 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 391595005990 Uncharacterized conserved protein [Function unknown]; Region: COG3743 391595005991 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 391595005992 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391595005993 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391595005994 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391595005995 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391595005996 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391595005997 GTPase CgtA; Reviewed; Region: obgE; PRK12299 391595005998 GTP1/OBG; Region: GTP1_OBG; pfam01018 391595005999 Obg GTPase; Region: Obg; cd01898 391595006000 G1 box; other site 391595006001 GTP/Mg2+ binding site [chemical binding]; other site 391595006002 Switch I region; other site 391595006003 G2 box; other site 391595006004 G3 box; other site 391595006005 Switch II region; other site 391595006006 G4 box; other site 391595006007 G5 box; other site 391595006008 gamma-glutamyl kinase; Provisional; Region: PRK05429 391595006009 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 391595006010 nucleotide binding site [chemical binding]; other site 391595006011 homotetrameric interface [polypeptide binding]; other site 391595006012 putative phosphate binding site [ion binding]; other site 391595006013 putative allosteric binding site; other site 391595006014 PUA domain; Region: PUA; pfam01472 391595006015 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 391595006016 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 391595006017 putative catalytic cysteine [active] 391595006018 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 391595006019 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 391595006020 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 391595006021 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391595006022 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391595006023 putative acyl-acceptor binding pocket; other site 391595006024 PA14 domain; Region: PA14; cl08459 391595006025 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 391595006026 rRNA interaction site [nucleotide binding]; other site 391595006027 S8 interaction site; other site 391595006028 putative laminin-1 binding site; other site 391595006029 elongation factor Ts; Provisional; Region: tsf; PRK09377 391595006030 UBA/TS-N domain; Region: UBA; pfam00627 391595006031 Elongation factor TS; Region: EF_TS; pfam00889 391595006032 Elongation factor TS; Region: EF_TS; pfam00889 391595006033 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 391595006034 Dehydroquinase class II; Region: DHquinase_II; pfam01220 391595006035 active site 391595006036 trimer interface [polypeptide binding]; other site 391595006037 dimer interface [polypeptide binding]; other site 391595006038 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 391595006039 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 391595006040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595006041 active site 391595006042 phosphorylation site [posttranslational modification] 391595006043 intermolecular recognition site; other site 391595006044 dimerization interface [polypeptide binding]; other site 391595006045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391595006046 DNA binding site [nucleotide binding] 391595006047 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 391595006048 PhoU domain; Region: PhoU; pfam01895 391595006049 PhoU domain; Region: PhoU; pfam01895 391595006050 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 391595006051 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 391595006052 Walker A/P-loop; other site 391595006053 ATP binding site [chemical binding]; other site 391595006054 Q-loop/lid; other site 391595006055 ABC transporter signature motif; other site 391595006056 Walker B; other site 391595006057 D-loop; other site 391595006058 H-loop/switch region; other site 391595006059 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 391595006060 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 391595006061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595006062 dimer interface [polypeptide binding]; other site 391595006063 conserved gate region; other site 391595006064 putative PBP binding loops; other site 391595006065 ABC-ATPase subunit interface; other site 391595006066 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 391595006067 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 391595006068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595006069 dimer interface [polypeptide binding]; other site 391595006070 conserved gate region; other site 391595006071 putative PBP binding loops; other site 391595006072 ABC-ATPase subunit interface; other site 391595006073 PBP superfamily domain; Region: PBP_like_2; pfam12849 391595006074 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 391595006075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595006076 dimer interface [polypeptide binding]; other site 391595006077 phosphorylation site [posttranslational modification] 391595006078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595006079 ATP binding site [chemical binding]; other site 391595006080 Mg2+ binding site [ion binding]; other site 391595006081 G-X-G motif; other site 391595006082 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 391595006083 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 391595006084 homodimer interface [polypeptide binding]; other site 391595006085 substrate-cofactor binding pocket; other site 391595006086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595006087 catalytic residue [active] 391595006088 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 391595006089 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 391595006090 trimer interface [polypeptide binding]; other site 391595006091 putative metal binding site [ion binding]; other site 391595006092 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 391595006093 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 391595006094 catalytic site [active] 391595006095 G-X2-G-X-G-K; other site 391595006096 hypothetical protein; Provisional; Region: PRK11820 391595006097 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 391595006098 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 391595006099 PAS domain; Region: PAS_5; pfam07310 391595006100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 391595006101 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 391595006102 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391595006103 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391595006104 conserved cys residue [active] 391595006105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595006106 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595006107 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 391595006108 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 391595006109 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391595006110 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 391595006111 putative ligand binding site [chemical binding]; other site 391595006112 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391595006113 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391595006114 Walker A/P-loop; other site 391595006115 ATP binding site [chemical binding]; other site 391595006116 Q-loop/lid; other site 391595006117 ABC transporter signature motif; other site 391595006118 Walker B; other site 391595006119 D-loop; other site 391595006120 H-loop/switch region; other site 391595006121 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391595006122 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391595006123 Walker A/P-loop; other site 391595006124 ATP binding site [chemical binding]; other site 391595006125 Q-loop/lid; other site 391595006126 ABC transporter signature motif; other site 391595006127 Walker B; other site 391595006128 D-loop; other site 391595006129 H-loop/switch region; other site 391595006130 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391595006131 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595006132 TM-ABC transporter signature motif; other site 391595006133 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 391595006134 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391595006135 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391595006136 TM-ABC transporter signature motif; other site 391595006137 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 391595006138 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 391595006139 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 391595006140 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391595006141 dimer interface [polypeptide binding]; other site 391595006142 active site 391595006143 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 391595006144 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 391595006145 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 391595006146 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 391595006147 trimer interface [polypeptide binding]; other site 391595006148 active site 391595006149 UDP-GlcNAc binding site [chemical binding]; other site 391595006150 lipid binding site [chemical binding]; lipid-binding site 391595006151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 391595006152 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391595006153 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391595006154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 391595006155 Peptidase M15; Region: Peptidase_M15_3; cl01194 391595006156 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 391595006157 TadE-like protein; Region: TadE; pfam07811 391595006158 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 391595006159 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 391595006160 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 391595006161 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 391595006162 23S rRNA interface [nucleotide binding]; other site 391595006163 L3 interface [polypeptide binding]; other site 391595006164 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391595006165 CoenzymeA binding site [chemical binding]; other site 391595006166 subunit interaction site [polypeptide binding]; other site 391595006167 PHB binding site; other site 391595006168 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 391595006169 Glucose inhibited division protein A; Region: GIDA; pfam01134 391595006170 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 391595006171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595006172 S-adenosylmethionine binding site [chemical binding]; other site 391595006173 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 391595006174 active site 391595006175 HIGH motif; other site 391595006176 nucleotide binding site [chemical binding]; other site 391595006177 active site 391595006178 KMSKS motif; other site 391595006179 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 391595006180 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 391595006181 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 391595006182 trimerization site [polypeptide binding]; other site 391595006183 active site 391595006184 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391595006185 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391595006186 dimer interface [polypeptide binding]; other site 391595006187 putative CheW interface [polypeptide binding]; other site 391595006188 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 391595006189 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 391595006190 generic binding surface II; other site 391595006191 ssDNA binding site; other site 391595006192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391595006193 ATP binding site [chemical binding]; other site 391595006194 putative Mg++ binding site [ion binding]; other site 391595006195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391595006196 nucleotide binding region [chemical binding]; other site 391595006197 ATP-binding site [chemical binding]; other site 391595006198 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 391595006199 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 391595006200 nucleotide binding pocket [chemical binding]; other site 391595006201 K-X-D-G motif; other site 391595006202 catalytic site [active] 391595006203 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 391595006204 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 391595006205 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 391595006206 Dimer interface [polypeptide binding]; other site 391595006207 BRCT sequence motif; other site 391595006208 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391595006209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595006210 active site 391595006211 phosphorylation site [posttranslational modification] 391595006212 intermolecular recognition site; other site 391595006213 dimerization interface [polypeptide binding]; other site 391595006214 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391595006215 DNA binding site [nucleotide binding] 391595006216 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 391595006217 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 391595006218 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 391595006219 Ligand Binding Site [chemical binding]; other site 391595006220 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 391595006221 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 391595006222 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 391595006223 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 391595006224 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 391595006225 active site 391595006226 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 391595006227 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 391595006228 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391595006229 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 391595006230 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391595006231 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391595006232 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391595006233 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391595006234 Surface antigen; Region: Bac_surface_Ag; pfam01103 391595006235 RIP metalloprotease RseP; Region: TIGR00054 391595006236 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 391595006237 active site 391595006238 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 391595006239 protein binding site [polypeptide binding]; other site 391595006240 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 391595006241 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 391595006242 putative substrate binding region [chemical binding]; other site 391595006243 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 391595006244 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 391595006245 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 391595006246 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 391595006247 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 391595006248 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 391595006249 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 391595006250 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 391595006251 catalytic residue [active] 391595006252 putative FPP diphosphate binding site; other site 391595006253 putative FPP binding hydrophobic cleft; other site 391595006254 dimer interface [polypeptide binding]; other site 391595006255 putative IPP diphosphate binding site; other site 391595006256 ribosome recycling factor; Reviewed; Region: frr; PRK00083 391595006257 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 391595006258 hinge region; other site 391595006259 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 391595006260 putative nucleotide binding site [chemical binding]; other site 391595006261 uridine monophosphate binding site [chemical binding]; other site 391595006262 homohexameric interface [polypeptide binding]; other site 391595006263 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 391595006264 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 391595006265 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 391595006266 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391595006267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595006268 dimer interface [polypeptide binding]; other site 391595006269 conserved gate region; other site 391595006270 putative PBP binding loops; other site 391595006271 ABC-ATPase subunit interface; other site 391595006272 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391595006273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595006274 conserved gate region; other site 391595006275 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 391595006276 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595006277 Walker A/P-loop; other site 391595006278 ATP binding site [chemical binding]; other site 391595006279 Q-loop/lid; other site 391595006280 ABC transporter signature motif; other site 391595006281 Walker B; other site 391595006282 D-loop; other site 391595006283 H-loop/switch region; other site 391595006284 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391595006285 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595006286 Walker A/P-loop; other site 391595006287 ATP binding site [chemical binding]; other site 391595006288 Q-loop/lid; other site 391595006289 ABC transporter signature motif; other site 391595006290 Walker B; other site 391595006291 D-loop; other site 391595006292 H-loop/switch region; other site 391595006293 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391595006294 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391595006295 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391595006296 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391595006297 catalytic residue [active] 391595006298 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 391595006299 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 391595006300 dimer interface [polypeptide binding]; other site 391595006301 ssDNA binding site [nucleotide binding]; other site 391595006302 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391595006303 Hint domain; Region: Hint_2; pfam13403 391595006304 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 391595006305 putative substrate binding site [chemical binding]; other site 391595006306 putative ATP binding site [chemical binding]; other site 391595006307 Uncharacterized conserved protein [Function unknown]; Region: COG0062 391595006308 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 391595006309 Nitrogen regulatory protein P-II; Region: P-II; smart00938 391595006310 glutamine synthetase; Provisional; Region: glnA; PRK09469 391595006311 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391595006312 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391595006313 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 391595006314 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391595006315 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391595006316 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391595006317 active site 391595006318 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 391595006319 active site 391595006320 catalytic triad [active] 391595006321 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 391595006322 BioY family; Region: BioY; pfam02632 391595006323 adenylosuccinate lyase; Provisional; Region: PRK07492 391595006324 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 391595006325 tetramer interface [polypeptide binding]; other site 391595006326 active site 391595006327 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 391595006328 FliG C-terminal domain; Region: FliG_C; pfam01706 391595006329 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 391595006330 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 391595006331 putative acyl-acceptor binding pocket; other site 391595006332 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 391595006333 aconitate hydratase; Validated; Region: PRK09277 391595006334 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 391595006335 substrate binding site [chemical binding]; other site 391595006336 ligand binding site [chemical binding]; other site 391595006337 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 391595006338 substrate binding site [chemical binding]; other site 391595006339 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 391595006340 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391595006341 heme exporter protein CcmC; Region: ccmC; TIGR01191 391595006342 heme exporter protein CcmB; Region: ccmB; TIGR01190 391595006343 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 391595006344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595006345 Walker A/P-loop; other site 391595006346 ATP binding site [chemical binding]; other site 391595006347 Q-loop/lid; other site 391595006348 ABC transporter signature motif; other site 391595006349 Walker B; other site 391595006350 D-loop; other site 391595006351 H-loop/switch region; other site 391595006352 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 391595006353 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 391595006354 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 391595006355 Protein export membrane protein; Region: SecD_SecF; pfam02355 391595006356 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 391595006357 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 391595006358 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 391595006359 Preprotein translocase subunit; Region: YajC; pfam02699 391595006360 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 391595006361 active site 391595006362 seryl-tRNA synthetase; Provisional; Region: PRK05431 391595006363 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 391595006364 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 391595006365 dimer interface [polypeptide binding]; other site 391595006366 active site 391595006367 motif 1; other site 391595006368 motif 2; other site 391595006369 motif 3; other site 391595006370 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391595006371 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391595006372 homoserine dehydrogenase; Provisional; Region: PRK06349 391595006373 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 391595006374 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 391595006375 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 391595006376 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 391595006377 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 391595006378 putative active site [active] 391595006379 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 391595006380 DHH family; Region: DHH; pfam01368 391595006381 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391595006382 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391595006383 HlyD family secretion protein; Region: HlyD_3; pfam13437 391595006384 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391595006385 Heme NO binding associated; Region: HNOBA; pfam07701 391595006386 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391595006387 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391595006388 metal binding site [ion binding]; metal-binding site 391595006389 active site 391595006390 I-site; other site 391595006391 Heme NO binding; Region: HNOB; pfam07700 391595006392 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 391595006393 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 391595006394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595006395 motif II; other site 391595006396 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 391595006397 Heavy-metal resistance; Region: Metal_resist; pfam13801 391595006398 RNA polymerase sigma factor; Provisional; Region: PRK12524 391595006399 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391595006400 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391595006401 DNA binding residues [nucleotide binding] 391595006402 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 391595006403 EF-hand domain pair; Region: EF_hand_5; pfam13499 391595006404 Ca2+ binding site [ion binding]; other site 391595006405 Protein of unknown function (DUF983); Region: DUF983; pfam06170 391595006406 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 391595006407 nudix motif; other site 391595006408 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 391595006409 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391595006410 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391595006411 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391595006412 active site 391595006413 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 391595006414 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 391595006415 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391595006416 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391595006417 active site 391595006418 catalytic tetrad [active] 391595006419 Uncharacterized conserved protein [Function unknown]; Region: COG4544 391595006420 YceI-like domain; Region: YceI; pfam04264 391595006421 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391595006422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595006423 putative substrate translocation pore; other site 391595006424 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 391595006425 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 391595006426 active site 391595006427 HIGH motif; other site 391595006428 KMSKS motif; other site 391595006429 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 391595006430 tRNA binding surface [nucleotide binding]; other site 391595006431 anticodon binding site; other site 391595006432 HAMP domain; Region: HAMP; pfam00672 391595006433 dimerization interface [polypeptide binding]; other site 391595006434 PAS domain; Region: PAS_9; pfam13426 391595006435 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391595006436 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391595006437 dimer interface [polypeptide binding]; other site 391595006438 putative CheW interface [polypeptide binding]; other site 391595006439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595006440 TPR motif; other site 391595006441 binding surface 391595006442 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595006443 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595006444 dimerization interface [polypeptide binding]; other site 391595006445 putative DNA binding site [nucleotide binding]; other site 391595006446 putative Zn2+ binding site [ion binding]; other site 391595006447 AsnC family; Region: AsnC_trans_reg; pfam01037 391595006448 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 391595006449 Proline dehydrogenase; Region: Pro_dh; pfam01619 391595006450 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 391595006451 Glutamate binding site [chemical binding]; other site 391595006452 NAD binding site [chemical binding]; other site 391595006453 catalytic residues [active] 391595006454 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 391595006455 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391595006456 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 391595006457 active site 391595006458 dimerization interface [polypeptide binding]; other site 391595006459 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 391595006460 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 391595006461 FMN binding site [chemical binding]; other site 391595006462 active site 391595006463 catalytic residues [active] 391595006464 substrate binding site [chemical binding]; other site 391595006465 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391595006466 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391595006467 active site 391595006468 DNA binding site [nucleotide binding] 391595006469 Int/Topo IB signature motif; other site 391595006470 RES domain; Region: RES; pfam08808 391595006471 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 391595006472 ParB-like nuclease domain; Region: ParBc; pfam02195 391595006473 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 391595006474 Berberine and berberine like; Region: BBE; pfam08031 391595006475 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595006476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595006477 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391595006478 dimerization interface [polypeptide binding]; other site 391595006479 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 391595006480 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391595006481 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391595006482 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391595006483 HlyD family secretion protein; Region: HlyD_3; pfam13437 391595006484 YHYH protein; Region: YHYH; pfam14240 391595006485 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 391595006486 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 391595006487 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391595006488 Sulfatase; Region: Sulfatase; pfam00884 391595006489 Domain of unknown function DUF302; Region: DUF302; pfam03625 391595006490 Domain of unknown function DUF302; Region: DUF302; pfam03625 391595006491 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595006492 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391595006493 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391595006494 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 391595006495 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 391595006496 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391595006497 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391595006498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595006499 dimer interface [polypeptide binding]; other site 391595006500 conserved gate region; other site 391595006501 putative PBP binding loops; other site 391595006502 ABC-ATPase subunit interface; other site 391595006503 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391595006504 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391595006505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595006506 dimer interface [polypeptide binding]; other site 391595006507 conserved gate region; other site 391595006508 putative PBP binding loops; other site 391595006509 ABC-ATPase subunit interface; other site 391595006510 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391595006511 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595006512 Walker A/P-loop; other site 391595006513 ATP binding site [chemical binding]; other site 391595006514 Q-loop/lid; other site 391595006515 ABC transporter signature motif; other site 391595006516 Walker B; other site 391595006517 D-loop; other site 391595006518 H-loop/switch region; other site 391595006519 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391595006520 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391595006521 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595006522 Walker A/P-loop; other site 391595006523 ATP binding site [chemical binding]; other site 391595006524 Q-loop/lid; other site 391595006525 ABC transporter signature motif; other site 391595006526 Walker B; other site 391595006527 D-loop; other site 391595006528 H-loop/switch region; other site 391595006529 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391595006530 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 391595006531 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 391595006532 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 391595006533 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 391595006534 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 391595006535 Phosphotransferase enzyme family; Region: APH; pfam01636 391595006536 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391595006537 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391595006538 Walker A/P-loop; other site 391595006539 ATP binding site [chemical binding]; other site 391595006540 Q-loop/lid; other site 391595006541 ABC transporter signature motif; other site 391595006542 Walker B; other site 391595006543 D-loop; other site 391595006544 H-loop/switch region; other site 391595006545 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391595006546 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595006547 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391595006548 TM-ABC transporter signature motif; other site 391595006549 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 391595006550 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391595006551 putative ligand binding site [chemical binding]; other site 391595006552 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391595006553 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 391595006554 Bacterial transcriptional regulator; Region: IclR; pfam01614 391595006555 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 391595006556 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 391595006557 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391595006558 catalytic loop [active] 391595006559 iron binding site [ion binding]; other site 391595006560 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 391595006561 BtpA family; Region: BtpA; cl00440 391595006562 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391595006563 active site 391595006564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595006565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595006566 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595006567 dimerization interface [polypeptide binding]; other site 391595006568 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391595006569 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391595006570 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595006571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595006572 dimer interface [polypeptide binding]; other site 391595006573 conserved gate region; other site 391595006574 putative PBP binding loops; other site 391595006575 ABC-ATPase subunit interface; other site 391595006576 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595006577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595006578 dimer interface [polypeptide binding]; other site 391595006579 conserved gate region; other site 391595006580 putative PBP binding loops; other site 391595006581 ABC-ATPase subunit interface; other site 391595006582 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595006583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595006584 Walker A/P-loop; other site 391595006585 ATP binding site [chemical binding]; other site 391595006586 Q-loop/lid; other site 391595006587 ABC transporter signature motif; other site 391595006588 Walker B; other site 391595006589 D-loop; other site 391595006590 H-loop/switch region; other site 391595006591 TOBE domain; Region: TOBE_2; pfam08402 391595006592 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 391595006593 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 391595006594 active site 391595006595 catalytic site [active] 391595006596 Zn binding site [ion binding]; other site 391595006597 tetramer interface [polypeptide binding]; other site 391595006598 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 391595006599 nucleoside/Zn binding site; other site 391595006600 dimer interface [polypeptide binding]; other site 391595006601 catalytic motif [active] 391595006602 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 391595006603 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391595006604 iron-sulfur cluster [ion binding]; other site 391595006605 [2Fe-2S] cluster binding site [ion binding]; other site 391595006606 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 391595006607 alpha subunit interface [polypeptide binding]; other site 391595006608 active site 391595006609 substrate binding site [chemical binding]; other site 391595006610 Fe binding site [ion binding]; other site 391595006611 Isochorismatase family; Region: Isochorismatase; pfam00857 391595006612 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 391595006613 catalytic triad [active] 391595006614 conserved cis-peptide bond; other site 391595006615 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391595006616 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391595006617 TM-ABC transporter signature motif; other site 391595006618 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391595006619 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595006620 TM-ABC transporter signature motif; other site 391595006621 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391595006622 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391595006623 Walker A/P-loop; other site 391595006624 ATP binding site [chemical binding]; other site 391595006625 Q-loop/lid; other site 391595006626 ABC transporter signature motif; other site 391595006627 Walker B; other site 391595006628 D-loop; other site 391595006629 H-loop/switch region; other site 391595006630 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391595006631 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391595006632 Walker A/P-loop; other site 391595006633 ATP binding site [chemical binding]; other site 391595006634 Q-loop/lid; other site 391595006635 ABC transporter signature motif; other site 391595006636 Walker B; other site 391595006637 D-loop; other site 391595006638 H-loop/switch region; other site 391595006639 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391595006640 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 391595006641 ligand binding site [chemical binding]; other site 391595006642 MarR family; Region: MarR_2; cl17246 391595006643 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391595006644 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 391595006645 high affinity sulphate transporter 1; Region: sulP; TIGR00815 391595006646 Sulfate transporter family; Region: Sulfate_transp; pfam00916 391595006647 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 391595006648 Putative phosphatase (DUF442); Region: DUF442; cl17385 391595006649 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 391595006650 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391595006651 Predicted transporter component [General function prediction only]; Region: COG2391 391595006652 Sulphur transport; Region: Sulf_transp; pfam04143 391595006653 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 391595006654 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 391595006655 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391595006656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595006657 S-adenosylmethionine binding site [chemical binding]; other site 391595006658 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 391595006659 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 391595006660 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 391595006661 [2Fe-2S] cluster binding site [ion binding]; other site 391595006662 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391595006663 active site residue [active] 391595006664 DsrE/DsrF-like family; Region: DrsE; pfam02635 391595006665 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391595006666 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391595006667 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391595006668 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595006669 ligand binding site [chemical binding]; other site 391595006670 flexible hinge region; other site 391595006671 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 391595006672 Electron transfer DM13; Region: DM13; pfam10517 391595006673 Helix-turn-helix domain; Region: HTH_18; pfam12833 391595006674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595006675 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391595006676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595006677 ATP binding site [chemical binding]; other site 391595006678 Mg2+ binding site [ion binding]; other site 391595006679 G-X-G motif; other site 391595006680 Helix-turn-helix domain; Region: HTH_18; pfam12833 391595006681 Helix-turn-helix domain; Region: HTH_18; pfam12833 391595006682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595006683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595006684 Protein of unknown function, DUF417; Region: DUF417; cl01162 391595006685 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 391595006686 GSH binding site [chemical binding]; other site 391595006687 catalytic residues [active] 391595006688 Uncharacterized conserved protein [Function unknown]; Region: COG2353 391595006689 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391595006690 putative catalytic site [active] 391595006691 putative phosphate binding site [ion binding]; other site 391595006692 putative metal binding site [ion binding]; other site 391595006693 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 391595006694 Sulfatase; Region: Sulfatase; cl17466 391595006695 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 391595006696 NMT1/THI5 like; Region: NMT1; pfam09084 391595006697 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391595006698 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391595006699 Walker A/P-loop; other site 391595006700 ATP binding site [chemical binding]; other site 391595006701 Q-loop/lid; other site 391595006702 ABC transporter signature motif; other site 391595006703 Walker B; other site 391595006704 D-loop; other site 391595006705 H-loop/switch region; other site 391595006706 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391595006707 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 391595006708 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391595006709 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 391595006710 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391595006711 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391595006712 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 391595006713 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 391595006714 active site 391595006715 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391595006716 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391595006717 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 391595006718 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 391595006719 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 391595006720 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391595006721 inhibitor-cofactor binding pocket; inhibition site 391595006722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595006723 catalytic residue [active] 391595006724 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391595006725 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391595006726 Walker A/P-loop; other site 391595006727 ATP binding site [chemical binding]; other site 391595006728 Q-loop/lid; other site 391595006729 ABC transporter signature motif; other site 391595006730 Walker B; other site 391595006731 D-loop; other site 391595006732 H-loop/switch region; other site 391595006733 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391595006734 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391595006735 Walker A/P-loop; other site 391595006736 ATP binding site [chemical binding]; other site 391595006737 Q-loop/lid; other site 391595006738 ABC transporter signature motif; other site 391595006739 Walker B; other site 391595006740 D-loop; other site 391595006741 H-loop/switch region; other site 391595006742 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391595006743 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391595006744 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391595006745 TM-ABC transporter signature motif; other site 391595006746 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595006747 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391595006748 TM-ABC transporter signature motif; other site 391595006749 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391595006750 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391595006751 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391595006752 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391595006753 conserved cys residue [active] 391595006754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595006755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595006756 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391595006757 classical (c) SDRs; Region: SDR_c; cd05233 391595006758 NAD(P) binding site [chemical binding]; other site 391595006759 active site 391595006760 aminotransferase; Provisional; Region: PRK06105 391595006761 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391595006762 inhibitor-cofactor binding pocket; inhibition site 391595006763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595006764 catalytic residue [active] 391595006765 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 391595006766 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391595006767 DctM-like transporters; Region: DctM; pfam06808 391595006768 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391595006769 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391595006770 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595006771 acetyl-CoA synthetase; Provisional; Region: PRK00174 391595006772 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 391595006773 active site 391595006774 CoA binding site [chemical binding]; other site 391595006775 acyl-activating enzyme (AAE) consensus motif; other site 391595006776 AMP binding site [chemical binding]; other site 391595006777 acetate binding site [chemical binding]; other site 391595006778 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 391595006779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 391595006780 Family of unknown function (DUF490); Region: DUF490; pfam04357 391595006781 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 391595006782 Surface antigen; Region: Bac_surface_Ag; pfam01103 391595006783 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 391595006784 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391595006785 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391595006786 Walker A/P-loop; other site 391595006787 ATP binding site [chemical binding]; other site 391595006788 Q-loop/lid; other site 391595006789 ABC transporter signature motif; other site 391595006790 Walker B; other site 391595006791 D-loop; other site 391595006792 H-loop/switch region; other site 391595006793 TOBE domain; Region: TOBE; pfam03459 391595006794 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 391595006795 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 391595006796 active site 391595006797 catalytic site [active] 391595006798 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 391595006799 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595006800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595006801 putative PBP binding loops; other site 391595006802 dimer interface [polypeptide binding]; other site 391595006803 ABC-ATPase subunit interface; other site 391595006804 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595006805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595006806 dimer interface [polypeptide binding]; other site 391595006807 conserved gate region; other site 391595006808 putative PBP binding loops; other site 391595006809 ABC-ATPase subunit interface; other site 391595006810 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595006811 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391595006812 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391595006813 DNA binding site [nucleotide binding] 391595006814 domain linker motif; other site 391595006815 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 391595006816 ligand binding site [chemical binding]; other site 391595006817 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 391595006818 beta-galactosidase; Region: BGL; TIGR03356 391595006819 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 391595006820 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595006821 DctM-like transporters; Region: DctM; pfam06808 391595006822 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391595006823 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391595006824 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 391595006825 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391595006826 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391595006827 active site 391595006828 catalytic tetrad [active] 391595006829 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 391595006830 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 391595006831 active site 391595006832 dimer interface [polypeptide binding]; other site 391595006833 non-prolyl cis peptide bond; other site 391595006834 insertion regions; other site 391595006835 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391595006836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595006837 DNA-binding site [nucleotide binding]; DNA binding site 391595006838 UTRA domain; Region: UTRA; pfam07702 391595006839 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595006840 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595006841 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391595006842 Predicted metal-binding protein [General function prediction only]; Region: COG3019 391595006843 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 391595006844 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 391595006845 Multicopper oxidase; Region: Cu-oxidase; pfam00394 391595006846 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 391595006847 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 391595006848 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 391595006849 DNA binding residues [nucleotide binding] 391595006850 dimer interface [polypeptide binding]; other site 391595006851 copper binding site [ion binding]; other site 391595006852 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391595006853 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391595006854 metal-binding site [ion binding] 391595006855 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391595006856 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391595006857 metal-binding site [ion binding] 391595006858 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391595006859 Soluble P-type ATPase [General function prediction only]; Region: COG4087 391595006860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595006861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595006862 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595006863 dimerization interface [polypeptide binding]; other site 391595006864 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 391595006865 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 391595006866 putative ligand binding site [chemical binding]; other site 391595006867 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391595006868 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391595006869 Walker A/P-loop; other site 391595006870 ATP binding site [chemical binding]; other site 391595006871 Q-loop/lid; other site 391595006872 ABC transporter signature motif; other site 391595006873 Walker B; other site 391595006874 D-loop; other site 391595006875 H-loop/switch region; other site 391595006876 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391595006877 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595006878 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391595006879 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391595006880 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595006881 TM-ABC transporter signature motif; other site 391595006882 dihydroxy-acid dehydratase; Validated; Region: PRK06131 391595006883 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595006884 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595006885 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391595006886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595006887 active site 391595006888 phosphorylation site [posttranslational modification] 391595006889 intermolecular recognition site; other site 391595006890 dimerization interface [polypeptide binding]; other site 391595006891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391595006892 DNA binding site [nucleotide binding] 391595006893 histidine kinase; Provisional; Region: PRK13557 391595006894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391595006895 putative active site [active] 391595006896 heme pocket [chemical binding]; other site 391595006897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595006898 dimer interface [polypeptide binding]; other site 391595006899 phosphorylation site [posttranslational modification] 391595006900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595006901 ATP binding site [chemical binding]; other site 391595006902 Mg2+ binding site [ion binding]; other site 391595006903 G-X-G motif; other site 391595006904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595006905 active site 391595006906 phosphorylation site [posttranslational modification] 391595006907 intermolecular recognition site; other site 391595006908 dimerization interface [polypeptide binding]; other site 391595006909 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 391595006910 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 391595006911 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 391595006912 iron-sulfur cluster [ion binding]; other site 391595006913 [2Fe-2S] cluster binding site [ion binding]; other site 391595006914 arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693 391595006915 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391595006916 molybdopterin cofactor binding site; other site 391595006917 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 391595006918 molybdopterin cofactor binding site; other site 391595006919 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 391595006920 HEAT repeats; Region: HEAT_2; pfam13646 391595006921 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391595006922 Resolvase, N terminal domain; Region: Resolvase; pfam00239 391595006923 catalytic residues [active] 391595006924 Recombinase; Region: Recombinase; pfam07508 391595006925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391595006926 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 391595006927 DNA binding residues [nucleotide binding] 391595006928 Predicted integral membrane protein [Function unknown]; Region: COG5616 391595006929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595006930 TPR motif; other site 391595006931 binding surface 391595006932 TPR repeat; Region: TPR_11; pfam13414 391595006933 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595006934 TPR motif; other site 391595006935 TPR repeat; Region: TPR_11; pfam13414 391595006936 binding surface 391595006937 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391595006938 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391595006939 DNA binding residues [nucleotide binding] 391595006940 dimerization interface [polypeptide binding]; other site 391595006941 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 391595006942 GAF domain; Region: GAF; pfam01590 391595006943 SnoaL-like domain; Region: SnoaL_2; pfam12680 391595006944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595006945 putative substrate translocation pore; other site 391595006946 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391595006947 Amino acid synthesis; Region: AA_synth; pfam06684 391595006948 Amino acid synthesis; Region: AA_synth; pfam06684 391595006949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595006950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595006951 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 391595006952 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 391595006953 homodimer interface [polypeptide binding]; other site 391595006954 active site 391595006955 TDP-binding site; other site 391595006956 Phage terminase, small subunit; Region: Terminase_4; cl01525 391595006957 Phage terminase, small subunit; Region: Terminase_4; pfam05119 391595006958 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 391595006959 DNA methylase; Region: N6_N4_Mtase; cl17433 391595006960 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 391595006961 active site 391595006962 Int/Topo IB signature motif; other site 391595006963 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 391595006964 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 391595006965 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 391595006966 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391595006967 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 391595006968 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 391595006969 dimer interface [polypeptide binding]; other site 391595006970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595006971 catalytic residue [active] 391595006972 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 391595006973 putative active site pocket [active] 391595006974 dimerization interface [polypeptide binding]; other site 391595006975 putative catalytic residue [active] 391595006976 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 391595006977 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 391595006978 dimer interface [polypeptide binding]; other site 391595006979 ADP-ribose binding site [chemical binding]; other site 391595006980 active site 391595006981 nudix motif; other site 391595006982 metal binding site [ion binding]; metal-binding site 391595006983 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 391595006984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595006985 S-adenosylmethionine binding site [chemical binding]; other site 391595006986 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 391595006987 DNA photolyase; Region: DNA_photolyase; pfam00875 391595006988 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391595006989 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391595006990 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595006991 catalytic residue [active] 391595006992 BCCT family transporter; Region: BCCT; pfam02028 391595006993 BCCT family transporter; Region: BCCT; pfam02028 391595006994 BCCT family transporter; Region: BCCT; pfam02028 391595006995 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 391595006996 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 391595006997 NADP binding site [chemical binding]; other site 391595006998 dimer interface [polypeptide binding]; other site 391595006999 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 391595007000 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595007001 DinB family; Region: DinB; cl17821 391595007002 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 391595007003 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 391595007004 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391595007005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595007006 DNA-binding site [nucleotide binding]; DNA binding site 391595007007 FCD domain; Region: FCD; pfam07729 391595007008 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 391595007009 nudix motif; other site 391595007010 SnoaL-like domain; Region: SnoaL_2; pfam12680 391595007011 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 391595007012 Chromate transporter; Region: Chromate_transp; pfam02417 391595007013 Stringent starvation protein B; Region: SspB; pfam04386 391595007014 fumarate hydratase; Reviewed; Region: fumC; PRK00485 391595007015 Class II fumarases; Region: Fumarase_classII; cd01362 391595007016 active site 391595007017 tetramer interface [polypeptide binding]; other site 391595007018 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 391595007019 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 391595007020 catalytic residue [active] 391595007021 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 391595007022 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 391595007023 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 391595007024 CPxP motif; other site 391595007025 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 391595007026 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391595007027 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 391595007028 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391595007029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595007030 active site 391595007031 phosphorylation site [posttranslational modification] 391595007032 intermolecular recognition site; other site 391595007033 dimerization interface [polypeptide binding]; other site 391595007034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595007035 Walker A motif; other site 391595007036 ATP binding site [chemical binding]; other site 391595007037 Walker B motif; other site 391595007038 arginine finger; other site 391595007039 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391595007040 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 391595007041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595007042 dimer interface [polypeptide binding]; other site 391595007043 phosphorylation site [posttranslational modification] 391595007044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595007045 ATP binding site [chemical binding]; other site 391595007046 Mg2+ binding site [ion binding]; other site 391595007047 G-X-G motif; other site 391595007048 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 391595007049 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 391595007050 putative active site [active] 391595007051 catalytic triad [active] 391595007052 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 391595007053 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 391595007054 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 391595007055 ATP binding site [chemical binding]; other site 391595007056 active site 391595007057 substrate binding site [chemical binding]; other site 391595007058 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 391595007059 methionine synthase I; Validated; Region: PRK07534 391595007060 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 391595007061 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 391595007062 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 391595007063 B12 binding site [chemical binding]; other site 391595007064 cobalt ligand [ion binding]; other site 391595007065 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 391595007066 Fe-S metabolism associated domain; Region: SufE; cl00951 391595007067 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 391595007068 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 391595007069 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 391595007070 catalytic site [active] 391595007071 putative active site [active] 391595007072 putative substrate binding site [chemical binding]; other site 391595007073 HRDC domain; Region: HRDC; pfam00570 391595007074 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 391595007075 active site 391595007076 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 391595007077 cosubstrate binding site; other site 391595007078 substrate binding site [chemical binding]; other site 391595007079 catalytic site [active] 391595007080 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 391595007081 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 391595007082 dimerization interface [polypeptide binding]; other site 391595007083 putative ATP binding site [chemical binding]; other site 391595007084 Surface antigen; Region: Bac_surface_Ag; pfam01103 391595007085 HAMP domain; Region: HAMP; pfam00672 391595007086 dimerization interface [polypeptide binding]; other site 391595007087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595007088 dimer interface [polypeptide binding]; other site 391595007089 phosphorylation site [posttranslational modification] 391595007090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595007091 ATP binding site [chemical binding]; other site 391595007092 Mg2+ binding site [ion binding]; other site 391595007093 G-X-G motif; other site 391595007094 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391595007095 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 391595007096 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 391595007097 active site 391595007098 catalytic site [active] 391595007099 substrate binding site [chemical binding]; other site 391595007100 BRCA1 C Terminus (BRCT) domain; Region: BRCT; pfam00533 391595007101 Dimer interface [polypeptide binding]; other site 391595007102 BRCT sequence motif; other site 391595007103 Terminase-like family; Region: Terminase_6; pfam03237 391595007104 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 391595007105 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 391595007106 putative active site [active] 391595007107 putative NTP binding site [chemical binding]; other site 391595007108 putative nucleic acid binding site [nucleotide binding]; other site 391595007109 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391595007110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595007111 non-specific DNA binding site [nucleotide binding]; other site 391595007112 salt bridge; other site 391595007113 sequence-specific DNA binding site [nucleotide binding]; other site 391595007114 Helix-turn-helix domain; Region: HTH_17; pfam12728 391595007115 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391595007116 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595007117 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595007118 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391595007119 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391595007120 active site 391595007121 Int/Topo IB signature motif; other site 391595007122 DNA binding site [nucleotide binding] 391595007123 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391595007124 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 391595007125 LytTr DNA-binding domain; Region: LytTR; smart00850 391595007126 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391595007127 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 391595007128 homodimer interface [polypeptide binding]; other site 391595007129 substrate-cofactor binding pocket; other site 391595007130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595007131 catalytic residue [active] 391595007132 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391595007133 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391595007134 Walker A/P-loop; other site 391595007135 ATP binding site [chemical binding]; other site 391595007136 Q-loop/lid; other site 391595007137 ABC transporter signature motif; other site 391595007138 Walker B; other site 391595007139 D-loop; other site 391595007140 H-loop/switch region; other site 391595007141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595007142 dimer interface [polypeptide binding]; other site 391595007143 conserved gate region; other site 391595007144 putative PBP binding loops; other site 391595007145 ABC-ATPase subunit interface; other site 391595007146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595007147 dimer interface [polypeptide binding]; other site 391595007148 conserved gate region; other site 391595007149 putative PBP binding loops; other site 391595007150 ABC-ATPase subunit interface; other site 391595007151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391595007152 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391595007153 substrate binding pocket [chemical binding]; other site 391595007154 membrane-bound complex binding site; other site 391595007155 hinge residues; other site 391595007156 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391595007157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595007158 DNA-binding site [nucleotide binding]; DNA binding site 391595007159 FCD domain; Region: FCD; pfam07729 391595007160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391595007161 Transposase; Region: HTH_Tnp_1; cl17663 391595007162 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 391595007163 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 391595007164 N- and C-terminal domain interface [polypeptide binding]; other site 391595007165 putative active site [active] 391595007166 putative MgATP binding site [chemical binding]; other site 391595007167 putative catalytic site [active] 391595007168 metal binding site [ion binding]; metal-binding site 391595007169 putative carbohydrate binding site [chemical binding]; other site 391595007170 Domain of unknown function (DUF718); Region: DUF718; pfam05336 391595007171 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391595007172 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595007173 TM-ABC transporter signature motif; other site 391595007174 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595007175 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391595007176 TM-ABC transporter signature motif; other site 391595007177 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391595007178 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391595007179 Walker A/P-loop; other site 391595007180 ATP binding site [chemical binding]; other site 391595007181 Q-loop/lid; other site 391595007182 ABC transporter signature motif; other site 391595007183 Walker B; other site 391595007184 D-loop; other site 391595007185 H-loop/switch region; other site 391595007186 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391595007187 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 391595007188 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 391595007189 ligand binding site [chemical binding]; other site 391595007190 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391595007191 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 391595007192 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391595007193 short chain dehydrogenase; Validated; Region: PRK08324 391595007194 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 391595007195 active site 391595007196 Zn2+ binding site [ion binding]; other site 391595007197 intersubunit interface [polypeptide binding]; other site 391595007198 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 391595007199 putative NAD(P) binding site [chemical binding]; other site 391595007200 active site 391595007201 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 391595007202 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 391595007203 Cache domain; Region: Cache_1; pfam02743 391595007204 PAS domain; Region: PAS_9; pfam13426 391595007205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391595007206 putative active site [active] 391595007207 heme pocket [chemical binding]; other site 391595007208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595007209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391595007210 dimer interface [polypeptide binding]; other site 391595007211 phosphorylation site [posttranslational modification] 391595007212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595007213 ATP binding site [chemical binding]; other site 391595007214 Mg2+ binding site [ion binding]; other site 391595007215 G-X-G motif; other site 391595007216 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 391595007217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595007218 active site 391595007219 phosphorylation site [posttranslational modification] 391595007220 intermolecular recognition site; other site 391595007221 dimerization interface [polypeptide binding]; other site 391595007222 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391595007223 DNA binding residues [nucleotide binding] 391595007224 dimerization interface [polypeptide binding]; other site 391595007225 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 391595007226 active site 391595007227 dimer interface [polypeptide binding]; other site 391595007228 metal binding site [ion binding]; metal-binding site 391595007229 shikimate kinase; Provisional; Region: PRK13946 391595007230 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 391595007231 ADP binding site [chemical binding]; other site 391595007232 magnesium binding site [ion binding]; other site 391595007233 putative shikimate binding site; other site 391595007234 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 391595007235 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391595007236 active site 391595007237 DNA binding site [nucleotide binding] 391595007238 Int/Topo IB signature motif; other site 391595007239 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 391595007240 Domain of unknown function DUF21; Region: DUF21; pfam01595 391595007241 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391595007242 Transporter associated domain; Region: CorC_HlyC; smart01091 391595007243 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595007244 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391595007245 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391595007246 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391595007247 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595007248 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 391595007249 Predicted membrane protein [Function unknown]; Region: COG4325 391595007250 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 391595007251 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391595007252 NMT1/THI5 like; Region: NMT1; pfam09084 391595007253 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 391595007254 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391595007255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595007256 dimer interface [polypeptide binding]; other site 391595007257 conserved gate region; other site 391595007258 putative PBP binding loops; other site 391595007259 ABC-ATPase subunit interface; other site 391595007260 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391595007261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595007262 dimer interface [polypeptide binding]; other site 391595007263 conserved gate region; other site 391595007264 putative PBP binding loops; other site 391595007265 ABC-ATPase subunit interface; other site 391595007266 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391595007267 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391595007268 Walker A/P-loop; other site 391595007269 ATP binding site [chemical binding]; other site 391595007270 Q-loop/lid; other site 391595007271 ABC transporter signature motif; other site 391595007272 Walker B; other site 391595007273 D-loop; other site 391595007274 H-loop/switch region; other site 391595007275 phenylhydantoinase; Validated; Region: PRK08323 391595007276 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 391595007277 tetramer interface [polypeptide binding]; other site 391595007278 active site 391595007279 allantoate amidohydrolase; Reviewed; Region: PRK12893 391595007280 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 391595007281 active site 391595007282 metal binding site [ion binding]; metal-binding site 391595007283 dimer interface [polypeptide binding]; other site 391595007284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595007285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595007286 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 391595007287 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 391595007288 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 391595007289 homodimer interface [polypeptide binding]; other site 391595007290 active site 391595007291 FMN binding site [chemical binding]; other site 391595007292 substrate binding site [chemical binding]; other site 391595007293 4Fe-4S binding domain; Region: Fer4; pfam00037 391595007294 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 391595007295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595007296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391595007297 CheB methylesterase; Region: CheB_methylest; pfam01339 391595007298 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 391595007299 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 391595007300 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 391595007301 PAS domain; Region: PAS_9; pfam13426 391595007302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391595007303 PAS fold; Region: PAS_3; pfam08447 391595007304 putative active site [active] 391595007305 heme pocket [chemical binding]; other site 391595007306 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 391595007307 active site 391595007308 catalytic residues [active] 391595007309 TfoX C-terminal domain; Region: TfoX_C; pfam04994 391595007310 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 391595007311 active site 391595007312 multimer interface [polypeptide binding]; other site 391595007313 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 391595007314 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391595007315 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391595007316 ABC transporter; Region: ABC_tran_2; pfam12848 391595007317 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391595007318 V4R domain; Region: V4R; cl15268 391595007319 MarC family integral membrane protein; Region: MarC; pfam01914 391595007320 Predicted aspartyl protease [General function prediction only]; Region: COG3577 391595007321 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 391595007322 catalytic motif [active] 391595007323 Catalytic residue [active] 391595007324 DNA polymerase III subunit chi; Validated; Region: PRK05728 391595007325 multifunctional aminopeptidase A; Provisional; Region: PRK00913 391595007326 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 391595007327 interface (dimer of trimers) [polypeptide binding]; other site 391595007328 Substrate-binding/catalytic site; other site 391595007329 Zn-binding sites [ion binding]; other site 391595007330 Predicted permeases [General function prediction only]; Region: COG0795 391595007331 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 391595007332 Predicted permeases [General function prediction only]; Region: COG0795 391595007333 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 391595007334 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 391595007335 Organic solvent tolerance protein; Region: OstA_C; pfam04453 391595007336 SurA N-terminal domain; Region: SurA_N; pfam09312 391595007337 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 391595007338 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 391595007339 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 391595007340 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 391595007341 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 391595007342 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 391595007343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595007344 S-adenosylmethionine binding site [chemical binding]; other site 391595007345 peptide chain release factor 1; Validated; Region: prfA; PRK00591 391595007346 This domain is found in peptide chain release factors; Region: PCRF; smart00937 391595007347 RF-1 domain; Region: RF-1; pfam00472 391595007348 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 391595007349 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 391595007350 agmatinase; Region: agmatinase; TIGR01230 391595007351 oligomer interface [polypeptide binding]; other site 391595007352 putative active site [active] 391595007353 Mn binding site [ion binding]; other site 391595007354 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 391595007355 agmatinase; Region: agmatinase; TIGR01230 391595007356 oligomer interface [polypeptide binding]; other site 391595007357 putative active site [active] 391595007358 Mn binding site [ion binding]; other site 391595007359 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391595007360 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391595007361 metal binding site [ion binding]; metal-binding site 391595007362 putative dimer interface [polypeptide binding]; other site 391595007363 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 391595007364 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 391595007365 homodimer interface [polypeptide binding]; other site 391595007366 metal binding site [ion binding]; metal-binding site 391595007367 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 391595007368 homodimer interface [polypeptide binding]; other site 391595007369 active site 391595007370 putative chemical substrate binding site [chemical binding]; other site 391595007371 metal binding site [ion binding]; metal-binding site 391595007372 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 391595007373 active site 391595007374 tetramer interface [polypeptide binding]; other site 391595007375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391595007376 hypothetical protein; Validated; Region: PRK00029 391595007377 Uncharacterized conserved protein [Function unknown]; Region: COG0397 391595007378 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595007379 EamA-like transporter family; Region: EamA; pfam00892 391595007380 EamA-like transporter family; Region: EamA; pfam00892 391595007381 helicase 45; Provisional; Region: PTZ00424 391595007382 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391595007383 ATP binding site [chemical binding]; other site 391595007384 Mg++ binding site [ion binding]; other site 391595007385 motif III; other site 391595007386 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391595007387 nucleotide binding region [chemical binding]; other site 391595007388 ATP-binding site [chemical binding]; other site 391595007389 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391595007390 metal binding site 2 [ion binding]; metal-binding site 391595007391 putative DNA binding helix; other site 391595007392 metal binding site 1 [ion binding]; metal-binding site 391595007393 dimer interface [polypeptide binding]; other site 391595007394 structural Zn2+ binding site [ion binding]; other site 391595007395 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595007396 EamA-like transporter family; Region: EamA; pfam00892 391595007397 enolase; Provisional; Region: eno; PRK00077 391595007398 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 391595007399 dimer interface [polypeptide binding]; other site 391595007400 metal binding site [ion binding]; metal-binding site 391595007401 substrate binding pocket [chemical binding]; other site 391595007402 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 391595007403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391595007404 Coenzyme A binding pocket [chemical binding]; other site 391595007405 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595007406 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 391595007407 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 391595007408 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 391595007409 active site 391595007410 HIGH motif; other site 391595007411 dimer interface [polypeptide binding]; other site 391595007412 KMSKS motif; other site 391595007413 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 391595007414 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391595007415 NAD binding site [chemical binding]; other site 391595007416 homodimer interface [polypeptide binding]; other site 391595007417 homotetramer interface [polypeptide binding]; other site 391595007418 active site 391595007419 ABC transporter ATPase component; Reviewed; Region: PRK11147 391595007420 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391595007421 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391595007422 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 391595007423 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 391595007424 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 391595007425 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 391595007426 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 391595007427 putative phosphate acyltransferase; Provisional; Region: PRK05331 391595007428 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 391595007429 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 391595007430 dimer interface [polypeptide binding]; other site 391595007431 active site 391595007432 CoA binding pocket [chemical binding]; other site 391595007433 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391595007434 IHF dimer interface [polypeptide binding]; other site 391595007435 IHF - DNA interface [nucleotide binding]; other site 391595007436 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 391595007437 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391595007438 DNA binding residues [nucleotide binding] 391595007439 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 391595007440 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 391595007441 trimer interface [polypeptide binding]; other site 391595007442 active site 391595007443 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 391595007444 trimer interface [polypeptide binding]; other site 391595007445 active site 391595007446 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 391595007447 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 391595007448 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 391595007449 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 391595007450 Sporulation related domain; Region: SPOR; pfam05036 391595007451 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 391595007452 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 391595007453 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 391595007454 active site 391595007455 HIGH motif; other site 391595007456 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391595007457 KMSK motif region; other site 391595007458 tRNA binding surface [nucleotide binding]; other site 391595007459 DALR anticodon binding domain; Region: DALR_1; smart00836 391595007460 anticodon binding site; other site 391595007461 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 391595007462 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391595007463 Zn2+ binding site [ion binding]; other site 391595007464 Mg2+ binding site [ion binding]; other site 391595007465 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 391595007466 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 391595007467 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 391595007468 putative catalytic site [active] 391595007469 putative phosphate binding site [ion binding]; other site 391595007470 active site 391595007471 metal binding site A [ion binding]; metal-binding site 391595007472 DNA binding site [nucleotide binding] 391595007473 putative AP binding site [nucleotide binding]; other site 391595007474 putative metal binding site B [ion binding]; other site 391595007475 Protein of unknown function (DUF533); Region: DUF533; pfam04391 391595007476 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 391595007477 putative metal binding site [ion binding]; other site 391595007478 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 391595007479 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 391595007480 active site 391595007481 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 391595007482 Predicted esterase [General function prediction only]; Region: COG0400 391595007483 putative hydrolase; Provisional; Region: PRK11460 391595007484 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 391595007485 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391595007486 helix-hairpin-helix signature motif; other site 391595007487 substrate binding pocket [chemical binding]; other site 391595007488 active site 391595007489 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 391595007490 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 391595007491 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391595007492 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 391595007493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595007494 S-adenosylmethionine binding site [chemical binding]; other site 391595007495 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 391595007496 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 391595007497 active site 391595007498 catalytic residues [active] 391595007499 metal binding site [ion binding]; metal-binding site 391595007500 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 391595007501 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 391595007502 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391595007503 active site 391595007504 HIGH motif; other site 391595007505 nucleotide binding site [chemical binding]; other site 391595007506 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 391595007507 KMSKS motif; other site 391595007508 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 391595007509 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 391595007510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391595007511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595007512 homodimer interface [polypeptide binding]; other site 391595007513 catalytic residue [active] 391595007514 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 391595007515 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391595007516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391595007517 Coenzyme A binding pocket [chemical binding]; other site 391595007518 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 391595007519 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 391595007520 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 391595007521 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 391595007522 active site 391595007523 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 391595007524 TSCPD domain; Region: TSCPD; pfam12637 391595007525 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 391595007526 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391595007527 DNA-binding site [nucleotide binding]; DNA binding site 391595007528 RNA-binding motif; other site 391595007529 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391595007530 DNA-binding site [nucleotide binding]; DNA binding site 391595007531 RNA-binding motif; other site 391595007532 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 391595007533 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 391595007534 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 391595007535 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 391595007536 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 391595007537 NAD binding site [chemical binding]; other site 391595007538 homotetramer interface [polypeptide binding]; other site 391595007539 homodimer interface [polypeptide binding]; other site 391595007540 substrate binding site [chemical binding]; other site 391595007541 active site 391595007542 LysE type translocator; Region: LysE; cl00565 391595007543 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391595007544 active site 391595007545 hypothetical protein; Provisional; Region: PRK07550 391595007546 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391595007547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595007548 homodimer interface [polypeptide binding]; other site 391595007549 catalytic residue [active] 391595007550 SurA N-terminal domain; Region: SurA_N_3; cl07813 391595007551 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 391595007552 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 391595007553 anthranilate synthase component I; Provisional; Region: PRK13573 391595007554 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 391595007555 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 391595007556 Predicted deacylase [General function prediction only]; Region: COG3608 391595007557 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 391595007558 putative active site [active] 391595007559 Zn binding site [ion binding]; other site 391595007560 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 391595007561 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391595007562 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391595007563 metal binding site [ion binding]; metal-binding site 391595007564 active site 391595007565 I-site; other site 391595007566 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391595007567 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 391595007568 NodB motif; other site 391595007569 putative active site [active] 391595007570 putative catalytic site [active] 391595007571 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 391595007572 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 391595007573 glutamine binding [chemical binding]; other site 391595007574 catalytic triad [active] 391595007575 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 391595007576 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391595007577 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 391595007578 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 391595007579 ligand binding site [chemical binding]; other site 391595007580 active site 391595007581 UGI interface [polypeptide binding]; other site 391595007582 catalytic site [active] 391595007583 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 391595007584 active site 391595007585 ribulose/triose binding site [chemical binding]; other site 391595007586 phosphate binding site [ion binding]; other site 391595007587 substrate (anthranilate) binding pocket [chemical binding]; other site 391595007588 product (indole) binding pocket [chemical binding]; other site 391595007589 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 391595007590 trimer interface [polypeptide binding]; other site 391595007591 dimer interface [polypeptide binding]; other site 391595007592 putative active site [active] 391595007593 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 391595007594 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 391595007595 dimer interface [polypeptide binding]; other site 391595007596 putative functional site; other site 391595007597 putative MPT binding site; other site 391595007598 LexA repressor; Validated; Region: PRK00215 391595007599 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 391595007600 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391595007601 Catalytic site [active] 391595007602 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 391595007603 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 391595007604 Competence protein; Region: Competence; pfam03772 391595007605 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 391595007606 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391595007607 active site 391595007608 HIGH motif; other site 391595007609 nucleotide binding site [chemical binding]; other site 391595007610 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 391595007611 active site 391595007612 KMSKS motif; other site 391595007613 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 391595007614 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 391595007615 dimer interface [polypeptide binding]; other site 391595007616 active site 391595007617 citrylCoA binding site [chemical binding]; other site 391595007618 NADH binding [chemical binding]; other site 391595007619 cationic pore residues; other site 391595007620 oxalacetate/citrate binding site [chemical binding]; other site 391595007621 coenzyme A binding site [chemical binding]; other site 391595007622 catalytic triad [active] 391595007623 enoyl-CoA hydratase; Provisional; Region: PRK08140 391595007624 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391595007625 substrate binding site [chemical binding]; other site 391595007626 oxyanion hole (OAH) forming residues; other site 391595007627 trimer interface [polypeptide binding]; other site 391595007628 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 391595007629 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 391595007630 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 391595007631 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 391595007632 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 391595007633 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 391595007634 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 391595007635 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 391595007636 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391595007637 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 391595007638 putative acyl-acceptor binding pocket; other site 391595007639 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 391595007640 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 391595007641 dimer interface [polypeptide binding]; other site 391595007642 PYR/PP interface [polypeptide binding]; other site 391595007643 TPP binding site [chemical binding]; other site 391595007644 substrate binding site [chemical binding]; other site 391595007645 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391595007646 TPP-binding site [chemical binding]; other site 391595007647 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 391595007648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595007649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595007650 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391595007651 putative effector binding pocket; other site 391595007652 dimerization interface [polypeptide binding]; other site 391595007653 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 391595007654 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 391595007655 dimerization interface [polypeptide binding]; other site 391595007656 ATP binding site [chemical binding]; other site 391595007657 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 391595007658 dimerization interface [polypeptide binding]; other site 391595007659 ATP binding site [chemical binding]; other site 391595007660 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 391595007661 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 391595007662 metal ion-dependent adhesion site (MIDAS); other site 391595007663 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 391595007664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595007665 Walker A motif; other site 391595007666 ATP binding site [chemical binding]; other site 391595007667 Walker B motif; other site 391595007668 arginine finger; other site 391595007669 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 391595007670 active site 391595007671 substrate binding pocket [chemical binding]; other site 391595007672 dimer interface [polypeptide binding]; other site 391595007673 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391595007674 active site 391595007675 replicative DNA helicase; Provisional; Region: PRK09165 391595007676 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 391595007677 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 391595007678 Walker A motif; other site 391595007679 ATP binding site [chemical binding]; other site 391595007680 Walker B motif; other site 391595007681 DNA binding loops [nucleotide binding] 391595007682 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 391595007683 metal ion-dependent adhesion site (MIDAS); other site 391595007684 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 391595007685 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 391595007686 active site 391595007687 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391595007688 dimer interface [polypeptide binding]; other site 391595007689 substrate binding site [chemical binding]; other site 391595007690 catalytic residues [active] 391595007691 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 391595007692 Permease; Region: Permease; pfam02405 391595007693 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 391595007694 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 391595007695 Walker A/P-loop; other site 391595007696 ATP binding site [chemical binding]; other site 391595007697 Q-loop/lid; other site 391595007698 ABC transporter signature motif; other site 391595007699 Walker B; other site 391595007700 D-loop; other site 391595007701 H-loop/switch region; other site 391595007702 DNA repair protein RadA; Provisional; Region: PRK11823 391595007703 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 391595007704 Walker A motif/ATP binding site; other site 391595007705 ATP binding site [chemical binding]; other site 391595007706 Walker B motif; other site 391595007707 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 391595007708 Colicin V production protein; Region: Colicin_V; pfam02674 391595007709 amidophosphoribosyltransferase; Provisional; Region: PRK09123 391595007710 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 391595007711 active site 391595007712 tetramer interface [polypeptide binding]; other site 391595007713 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391595007714 active site 391595007715 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 391595007716 KR domain; Region: KR; pfam08659 391595007717 classical (c) SDRs; Region: SDR_c; cd05233 391595007718 NAD(P) binding site [chemical binding]; other site 391595007719 active site 391595007720 stationary phase survival protein SurE; Provisional; Region: PRK13931 391595007721 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 391595007722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595007723 S-adenosylmethionine binding site [chemical binding]; other site 391595007724 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 391595007725 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 391595007726 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 391595007727 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391595007728 Peptidase family M23; Region: Peptidase_M23; pfam01551 391595007729 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 391595007730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595007731 Walker A motif; other site 391595007732 ATP binding site [chemical binding]; other site 391595007733 Walker B motif; other site 391595007734 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 391595007735 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 391595007736 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 391595007737 Predicted transcriptional regulator [Transcription]; Region: COG2378 391595007738 HTH domain; Region: HTH_11; pfam08279 391595007739 WYL domain; Region: WYL; pfam13280 391595007740 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 391595007741 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 391595007742 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595007743 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391595007744 Walker A/P-loop; other site 391595007745 ATP binding site [chemical binding]; other site 391595007746 Q-loop/lid; other site 391595007747 ABC transporter signature motif; other site 391595007748 Walker B; other site 391595007749 D-loop; other site 391595007750 H-loop/switch region; other site 391595007751 TOBE domain; Region: TOBE_2; pfam08402 391595007752 short chain dehydrogenase; Provisional; Region: PRK08339 391595007753 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 391595007754 putative NAD(P) binding site [chemical binding]; other site 391595007755 putative active site [active] 391595007756 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 391595007757 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 391595007758 G1 box; other site 391595007759 putative GEF interaction site [polypeptide binding]; other site 391595007760 GTP/Mg2+ binding site [chemical binding]; other site 391595007761 Switch I region; other site 391595007762 G2 box; other site 391595007763 G3 box; other site 391595007764 Switch II region; other site 391595007765 G4 box; other site 391595007766 G5 box; other site 391595007767 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 391595007768 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391595007769 DEAD-like helicases superfamily; Region: DEXDc; smart00487 391595007770 ATP binding site [chemical binding]; other site 391595007771 Mg++ binding site [ion binding]; other site 391595007772 motif III; other site 391595007773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391595007774 nucleotide binding region [chemical binding]; other site 391595007775 ATP-binding site [chemical binding]; other site 391595007776 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 391595007777 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391595007778 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 391595007779 pantothenate kinase; Reviewed; Region: PRK13318 391595007780 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 391595007781 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 391595007782 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 391595007783 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 391595007784 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391595007785 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 391595007786 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391595007787 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 391595007788 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 391595007789 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391595007790 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 391595007791 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 391595007792 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 391595007793 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 391595007794 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 391595007795 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 391595007796 4Fe-4S binding domain; Region: Fer4; pfam00037 391595007797 4Fe-4S binding domain; Region: Fer4; pfam00037 391595007798 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 391595007799 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 391595007800 NADH dehydrogenase subunit G; Validated; Region: PRK09130 391595007801 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391595007802 catalytic loop [active] 391595007803 iron binding site [ion binding]; other site 391595007804 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 391595007805 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391595007806 molybdopterin cofactor binding site; other site 391595007807 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 391595007808 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 391595007809 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 391595007810 SLBB domain; Region: SLBB; pfam10531 391595007811 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 391595007812 Uncharacterized conserved protein [Function unknown]; Region: COG3743 391595007813 NADH dehydrogenase subunit E; Validated; Region: PRK07539 391595007814 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 391595007815 putative dimer interface [polypeptide binding]; other site 391595007816 [2Fe-2S] cluster binding site [ion binding]; other site 391595007817 Uncharacterized conserved protein [Function unknown]; Region: COG3743 391595007818 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 391595007819 NADH dehydrogenase subunit D; Validated; Region: PRK06075 391595007820 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 391595007821 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 391595007822 NADH dehydrogenase subunit B; Validated; Region: PRK06411 391595007823 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 391595007824 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 391595007825 Fasciclin domain; Region: Fasciclin; pfam02469 391595007826 enoyl-CoA hydratase; Provisional; Region: PRK07468 391595007827 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391595007828 substrate binding site [chemical binding]; other site 391595007829 oxyanion hole (OAH) forming residues; other site 391595007830 trimer interface [polypeptide binding]; other site 391595007831 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 391595007832 active site 391595007833 catalytic residues [active] 391595007834 metal binding site [ion binding]; metal-binding site 391595007835 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391595007836 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 391595007837 putative C-terminal domain interface [polypeptide binding]; other site 391595007838 putative GSH binding site (G-site) [chemical binding]; other site 391595007839 putative dimer interface [polypeptide binding]; other site 391595007840 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391595007841 N-terminal domain interface [polypeptide binding]; other site 391595007842 dimer interface [polypeptide binding]; other site 391595007843 substrate binding pocket (H-site) [chemical binding]; other site 391595007844 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 391595007845 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391595007846 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391595007847 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391595007848 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391595007849 carboxyltransferase (CT) interaction site; other site 391595007850 biotinylation site [posttranslational modification]; other site 391595007851 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 391595007852 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 391595007853 isovaleryl-CoA dehydrogenase; Region: PLN02519 391595007854 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391595007855 active site 391595007856 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391595007857 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595007858 catalytic residue [active] 391595007859 phosphoglycolate phosphatase; Provisional; Region: PRK13222 391595007860 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391595007861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595007862 motif II; other site 391595007863 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 391595007864 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 391595007865 Substrate binding site; other site 391595007866 Mg++ binding site; other site 391595007867 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 391595007868 active site 391595007869 substrate binding site [chemical binding]; other site 391595007870 CoA binding site [chemical binding]; other site 391595007871 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 391595007872 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 391595007873 glutaminase active site [active] 391595007874 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 391595007875 dimer interface [polypeptide binding]; other site 391595007876 active site 391595007877 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 391595007878 dimer interface [polypeptide binding]; other site 391595007879 active site 391595007880 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 391595007881 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 391595007882 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595007883 FeS/SAM binding site; other site 391595007884 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 391595007885 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 391595007886 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 391595007887 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391595007888 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391595007889 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391595007890 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391595007891 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391595007892 metal binding site [ion binding]; metal-binding site 391595007893 putative dimer interface [polypeptide binding]; other site 391595007894 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595007895 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391595007896 acetylornithine deacetylase; Provisional; Region: PRK07522 391595007897 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 391595007898 metal binding site [ion binding]; metal-binding site 391595007899 putative dimer interface [polypeptide binding]; other site 391595007900 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391595007901 classical (c) SDRs; Region: SDR_c; cd05233 391595007902 NAD(P) binding site [chemical binding]; other site 391595007903 active site 391595007904 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595007905 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391595007906 Walker A/P-loop; other site 391595007907 ATP binding site [chemical binding]; other site 391595007908 Q-loop/lid; other site 391595007909 ABC transporter signature motif; other site 391595007910 Walker B; other site 391595007911 D-loop; other site 391595007912 H-loop/switch region; other site 391595007913 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 391595007914 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595007915 Walker A/P-loop; other site 391595007916 ATP binding site [chemical binding]; other site 391595007917 Q-loop/lid; other site 391595007918 ABC transporter signature motif; other site 391595007919 Walker B; other site 391595007920 D-loop; other site 391595007921 H-loop/switch region; other site 391595007922 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 391595007923 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391595007924 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 391595007925 peptide binding site [polypeptide binding]; other site 391595007926 dimer interface [polypeptide binding]; other site 391595007927 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391595007928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595007929 dimer interface [polypeptide binding]; other site 391595007930 conserved gate region; other site 391595007931 putative PBP binding loops; other site 391595007932 ABC-ATPase subunit interface; other site 391595007933 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391595007934 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391595007935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595007936 dimer interface [polypeptide binding]; other site 391595007937 conserved gate region; other site 391595007938 putative PBP binding loops; other site 391595007939 ABC-ATPase subunit interface; other site 391595007940 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 391595007941 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 391595007942 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 391595007943 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 391595007944 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 391595007945 ligand binding site [chemical binding]; other site 391595007946 homodimer interface [polypeptide binding]; other site 391595007947 NAD(P) binding site [chemical binding]; other site 391595007948 trimer interface B [polypeptide binding]; other site 391595007949 trimer interface A [polypeptide binding]; other site 391595007950 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 391595007951 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 391595007952 classical (c) SDRs; Region: SDR_c; cd05233 391595007953 NAD(P) binding site [chemical binding]; other site 391595007954 active site 391595007955 Peptidase C26; Region: Peptidase_C26; pfam07722 391595007956 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 391595007957 catalytic triad [active] 391595007958 malate synthase G; Provisional; Region: PRK02999 391595007959 active site 391595007960 aminopeptidase N; Provisional; Region: pepN; PRK14015 391595007961 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 391595007962 Zn binding site [ion binding]; other site 391595007963 short chain dehydrogenase; Provisional; Region: PRK06123 391595007964 classical (c) SDRs; Region: SDR_c; cd05233 391595007965 NAD(P) binding site [chemical binding]; other site 391595007966 active site 391595007967 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391595007968 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391595007969 catalytic residue [active] 391595007970 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 391595007971 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 391595007972 GatB domain; Region: GatB_Yqey; smart00845 391595007973 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391595007974 active site 391595007975 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 391595007976 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391595007977 HSP70 interaction site [polypeptide binding]; other site 391595007978 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 391595007979 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 391595007980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391595007981 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 391595007982 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 391595007983 metal ion-dependent adhesion site (MIDAS); other site 391595007984 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391595007985 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391595007986 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 391595007987 active site 391595007988 Domain of unknown function (DUF427); Region: DUF427; pfam04248 391595007989 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 391595007990 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 391595007991 Cl- selectivity filter; other site 391595007992 Cl- binding residues [ion binding]; other site 391595007993 pore gating glutamate residue; other site 391595007994 dimer interface [polypeptide binding]; other site 391595007995 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 391595007996 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 391595007997 Walker A/P-loop; other site 391595007998 ATP binding site [chemical binding]; other site 391595007999 Q-loop/lid; other site 391595008000 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 391595008001 ABC transporter signature motif; other site 391595008002 Walker B; other site 391595008003 D-loop; other site 391595008004 H-loop/switch region; other site 391595008005 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 391595008006 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 391595008007 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 391595008008 cell division protein FtsZ; Validated; Region: PRK09330 391595008009 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 391595008010 nucleotide binding site [chemical binding]; other site 391595008011 SulA interaction site; other site 391595008012 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 391595008013 Cell division protein FtsA; Region: FtsA; smart00842 391595008014 Cell division protein FtsA; Region: FtsA; pfam14450 391595008015 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 391595008016 Cell division protein FtsQ; Region: FtsQ; pfam03799 391595008017 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 391595008018 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 391595008019 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391595008020 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 391595008021 FAD binding domain; Region: FAD_binding_4; pfam01565 391595008022 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 391595008023 Protein of unknown function (DUF2484); Region: DUF2484; pfam10658 391595008024 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 391595008025 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391595008026 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391595008027 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391595008028 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 391595008029 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 391595008030 active site 391595008031 homodimer interface [polypeptide binding]; other site 391595008032 cell division protein FtsW; Region: ftsW; TIGR02614 391595008033 Predicted flavoproteins [General function prediction only]; Region: COG2081 391595008034 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595008035 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 391595008036 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 391595008037 NAD(P) binding pocket [chemical binding]; other site 391595008038 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391595008039 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 391595008040 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 391595008041 Mg++ binding site [ion binding]; other site 391595008042 putative catalytic motif [active] 391595008043 putative substrate binding site [chemical binding]; other site 391595008044 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 391595008045 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391595008046 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391595008047 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 391595008048 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391595008049 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391595008050 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391595008051 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 391595008052 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 391595008053 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 391595008054 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 391595008055 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 391595008056 MraW methylase family; Region: Methyltransf_5; cl17771 391595008057 cell division protein MraZ; Reviewed; Region: PRK00326 391595008058 MraZ protein; Region: MraZ; pfam02381 391595008059 MraZ protein; Region: MraZ; pfam02381 391595008060 Domain of unknown function DUF59; Region: DUF59; pfam01883 391595008061 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 391595008062 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 391595008063 Walker A motif; other site 391595008064 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391595008065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 391595008066 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 391595008067 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 391595008068 Part of AAA domain; Region: AAA_19; pfam13245 391595008069 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 391595008070 Family description; Region: UvrD_C_2; pfam13538 391595008071 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 391595008072 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391595008073 phosphate binding site [ion binding]; other site 391595008074 pyruvate carboxylase; Reviewed; Region: PRK12999 391595008075 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391595008076 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391595008077 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391595008078 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 391595008079 active site 391595008080 catalytic residues [active] 391595008081 metal binding site [ion binding]; metal-binding site 391595008082 homodimer binding site [polypeptide binding]; other site 391595008083 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391595008084 carboxyltransferase (CT) interaction site; other site 391595008085 biotinylation site [posttranslational modification]; other site 391595008086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391595008087 Transposase; Region: HTH_Tnp_1; cl17663 391595008088 CheD chemotactic sensory transduction; Region: CheD; cl00810 391595008089 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 391595008090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595008091 active site 391595008092 phosphorylation site [posttranslational modification] 391595008093 intermolecular recognition site; other site 391595008094 dimerization interface [polypeptide binding]; other site 391595008095 CheB methylesterase; Region: CheB_methylest; pfam01339 391595008096 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391595008097 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391595008098 active site 391595008099 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 391595008100 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 391595008101 FtsX-like permease family; Region: FtsX; pfam02687 391595008102 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391595008103 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391595008104 Walker A/P-loop; other site 391595008105 ATP binding site [chemical binding]; other site 391595008106 Q-loop/lid; other site 391595008107 ABC transporter signature motif; other site 391595008108 Walker B; other site 391595008109 D-loop; other site 391595008110 H-loop/switch region; other site 391595008111 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 391595008112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391595008113 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391595008114 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 391595008115 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 391595008116 PUCC protein; Region: PUCC; pfam03209 391595008117 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 391595008118 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 391595008119 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 391595008120 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 391595008121 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391595008122 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 391595008123 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 391595008124 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391595008125 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 391595008126 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 391595008127 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595008128 AsnC family; Region: AsnC_trans_reg; pfam01037 391595008129 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 391595008130 putative active site pocket [active] 391595008131 4-fold oligomerization interface [polypeptide binding]; other site 391595008132 metal binding residues [ion binding]; metal-binding site 391595008133 3-fold/trimer interface [polypeptide binding]; other site 391595008134 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 391595008135 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 391595008136 putative active site [active] 391595008137 oxyanion strand; other site 391595008138 catalytic triad [active] 391595008139 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 391595008140 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 391595008141 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 391595008142 catalytic residues [active] 391595008143 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 391595008144 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 391595008145 substrate binding site [chemical binding]; other site 391595008146 glutamase interaction surface [polypeptide binding]; other site 391595008147 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 391595008148 metal binding site [ion binding]; metal-binding site 391595008149 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 391595008150 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 391595008151 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 391595008152 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 391595008153 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 391595008154 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 391595008155 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 391595008156 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391595008157 active site 391595008158 metal binding site [ion binding]; metal-binding site 391595008159 hexamer interface [polypeptide binding]; other site 391595008160 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595008161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595008162 dimer interface [polypeptide binding]; other site 391595008163 conserved gate region; other site 391595008164 putative PBP binding loops; other site 391595008165 ABC-ATPase subunit interface; other site 391595008166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595008167 dimer interface [polypeptide binding]; other site 391595008168 conserved gate region; other site 391595008169 putative PBP binding loops; other site 391595008170 ABC-ATPase subunit interface; other site 391595008171 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391595008172 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391595008173 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595008174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595008175 Walker A/P-loop; other site 391595008176 ATP binding site [chemical binding]; other site 391595008177 Q-loop/lid; other site 391595008178 ABC transporter signature motif; other site 391595008179 Walker B; other site 391595008180 D-loop; other site 391595008181 H-loop/switch region; other site 391595008182 TOBE domain; Region: TOBE_2; pfam08402 391595008183 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391595008184 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 391595008185 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391595008186 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 391595008187 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391595008188 active site 391595008189 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 391595008190 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391595008191 active site 391595008192 metal binding site [ion binding]; metal-binding site 391595008193 hexamer interface [polypeptide binding]; other site 391595008194 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595008195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595008196 dimer interface [polypeptide binding]; other site 391595008197 conserved gate region; other site 391595008198 putative PBP binding loops; other site 391595008199 ABC-ATPase subunit interface; other site 391595008200 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595008201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595008202 dimer interface [polypeptide binding]; other site 391595008203 conserved gate region; other site 391595008204 putative PBP binding loops; other site 391595008205 ABC-ATPase subunit interface; other site 391595008206 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595008207 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391595008208 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595008209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595008210 Walker A/P-loop; other site 391595008211 ATP binding site [chemical binding]; other site 391595008212 Q-loop/lid; other site 391595008213 ABC transporter signature motif; other site 391595008214 Walker B; other site 391595008215 D-loop; other site 391595008216 H-loop/switch region; other site 391595008217 TOBE domain; Region: TOBE_2; pfam08402 391595008218 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391595008219 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 391595008220 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391595008221 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 391595008222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391595008223 putative active site [active] 391595008224 heme pocket [chemical binding]; other site 391595008225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595008226 dimer interface [polypeptide binding]; other site 391595008227 phosphorylation site [posttranslational modification] 391595008228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595008229 ATP binding site [chemical binding]; other site 391595008230 Mg2+ binding site [ion binding]; other site 391595008231 G-X-G motif; other site 391595008232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595008233 Response regulator receiver domain; Region: Response_reg; pfam00072 391595008234 active site 391595008235 phosphorylation site [posttranslational modification] 391595008236 intermolecular recognition site; other site 391595008237 dimerization interface [polypeptide binding]; other site 391595008238 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 391595008239 Moco binding site; other site 391595008240 metal coordination site [ion binding]; other site 391595008241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391595008242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595008243 active site 391595008244 phosphorylation site [posttranslational modification] 391595008245 intermolecular recognition site; other site 391595008246 dimerization interface [polypeptide binding]; other site 391595008247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391595008248 DNA binding residues [nucleotide binding] 391595008249 dimerization interface [polypeptide binding]; other site 391595008250 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391595008251 catalytic core [active] 391595008252 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391595008253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595008254 DNA-binding site [nucleotide binding]; DNA binding site 391595008255 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 391595008256 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391595008257 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 391595008258 putative ligand binding site [chemical binding]; other site 391595008259 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595008260 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391595008261 TM-ABC transporter signature motif; other site 391595008262 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391595008263 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391595008264 TM-ABC transporter signature motif; other site 391595008265 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391595008266 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391595008267 Walker A/P-loop; other site 391595008268 ATP binding site [chemical binding]; other site 391595008269 Q-loop/lid; other site 391595008270 ABC transporter signature motif; other site 391595008271 Walker B; other site 391595008272 D-loop; other site 391595008273 H-loop/switch region; other site 391595008274 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391595008275 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391595008276 Walker A/P-loop; other site 391595008277 ATP binding site [chemical binding]; other site 391595008278 Q-loop/lid; other site 391595008279 ABC transporter signature motif; other site 391595008280 Walker B; other site 391595008281 D-loop; other site 391595008282 H-loop/switch region; other site 391595008283 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391595008284 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 391595008285 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 391595008286 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 391595008287 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391595008288 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595008289 Sporulation related domain; Region: SPOR; pfam05036 391595008290 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 391595008291 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 391595008292 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 391595008293 thymidylate kinase; Validated; Region: tmk; PRK00698 391595008294 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 391595008295 TMP-binding site; other site 391595008296 ATP-binding site [chemical binding]; other site 391595008297 DNA polymerase III subunit delta'; Validated; Region: PRK07471 391595008298 AAA ATPase domain; Region: AAA_16; pfam13191 391595008299 DNA polymerase III subunit delta'; Validated; Region: PRK08485 391595008300 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 391595008301 active site 391595008302 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 391595008303 putative hydrolase; Provisional; Region: PRK02113 391595008304 Predicted permeases [General function prediction only]; Region: COG0679 391595008305 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391595008306 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391595008307 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391595008308 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391595008309 active site 391595008310 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 391595008311 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595008312 catalytic residue [active] 391595008313 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 391595008314 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391595008315 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391595008316 active site 391595008317 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 391595008318 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 391595008319 putative active site [active] 391595008320 Zn binding site [ion binding]; other site 391595008321 phosphoglycolate phosphatase; Provisional; Region: PRK13222 391595008322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595008323 motif II; other site 391595008324 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 391595008325 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 391595008326 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 391595008327 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595008328 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391595008329 Walker A/P-loop; other site 391595008330 ATP binding site [chemical binding]; other site 391595008331 Q-loop/lid; other site 391595008332 ABC transporter signature motif; other site 391595008333 Walker B; other site 391595008334 D-loop; other site 391595008335 H-loop/switch region; other site 391595008336 TOBE domain; Region: TOBE_2; pfam08402 391595008337 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595008338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595008339 dimer interface [polypeptide binding]; other site 391595008340 conserved gate region; other site 391595008341 putative PBP binding loops; other site 391595008342 ABC-ATPase subunit interface; other site 391595008343 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 391595008344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595008345 putative PBP binding loops; other site 391595008346 dimer interface [polypeptide binding]; other site 391595008347 ABC-ATPase subunit interface; other site 391595008348 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595008349 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391595008350 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391595008351 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391595008352 DNA binding site [nucleotide binding] 391595008353 domain linker motif; other site 391595008354 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 391595008355 dimerization interface [polypeptide binding]; other site 391595008356 ligand binding site [chemical binding]; other site 391595008357 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 391595008358 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391595008359 ABC-ATPase subunit interface; other site 391595008360 dimer interface [polypeptide binding]; other site 391595008361 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 391595008362 putative PBP binding regions; other site 391595008363 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 391595008364 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 391595008365 putative ligand binding residues [chemical binding]; other site 391595008366 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 391595008367 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 391595008368 Walker A/P-loop; other site 391595008369 ATP binding site [chemical binding]; other site 391595008370 Q-loop/lid; other site 391595008371 ABC transporter signature motif; other site 391595008372 Walker B; other site 391595008373 D-loop; other site 391595008374 H-loop/switch region; other site 391595008375 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 391595008376 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 391595008377 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 391595008378 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391595008379 Predicted permease; Region: DUF318; cl17795 391595008380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595008381 dimerization interface [polypeptide binding]; other site 391595008382 putative DNA binding site [nucleotide binding]; other site 391595008383 putative Zn2+ binding site [ion binding]; other site 391595008384 acyl-CoA esterase; Provisional; Region: PRK10673 391595008385 PGAP1-like protein; Region: PGAP1; pfam07819 391595008386 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 391595008387 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391595008388 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 391595008389 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 391595008390 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391595008391 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391595008392 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 391595008393 IMP binding site; other site 391595008394 dimer interface [polypeptide binding]; other site 391595008395 partial ornithine binding site; other site 391595008396 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 391595008397 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 391595008398 dimer interface [polypeptide binding]; other site 391595008399 active site 391595008400 CoA binding pocket [chemical binding]; other site 391595008401 thymidine kinase; Provisional; Region: PRK04296 391595008402 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 391595008403 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391595008404 dimerization interface [polypeptide binding]; other site 391595008405 ligand binding site [chemical binding]; other site 391595008406 NADP binding site [chemical binding]; other site 391595008407 catalytic site [active] 391595008408 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 391595008409 dimer interface [polypeptide binding]; other site 391595008410 putative tRNA-binding site [nucleotide binding]; other site 391595008411 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 391595008412 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 391595008413 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 391595008414 Membrane fusogenic activity; Region: BMFP; pfam04380 391595008415 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 391595008416 Uncharacterized conserved protein [Function unknown]; Region: COG1565 391595008417 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 391595008418 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 391595008419 Hint domain; Region: Hint_2; pfam13403 391595008420 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595008421 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595008422 putative DNA binding site [nucleotide binding]; other site 391595008423 putative Zn2+ binding site [ion binding]; other site 391595008424 AsnC family; Region: AsnC_trans_reg; pfam01037 391595008425 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 391595008426 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595008427 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391595008428 Cytochrome P450; Region: p450; cl12078 391595008429 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 391595008430 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 391595008431 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 391595008432 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 391595008433 putative dimer interface [polypeptide binding]; other site 391595008434 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 391595008435 AIR carboxylase; Region: AIRC; pfam00731 391595008436 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 391595008437 ATP-grasp domain; Region: ATP-grasp; pfam02222 391595008438 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 391595008439 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595008440 active site 391595008441 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 391595008442 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 391595008443 nudix motif; other site 391595008444 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 391595008445 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 391595008446 ring oligomerisation interface [polypeptide binding]; other site 391595008447 ATP/Mg binding site [chemical binding]; other site 391595008448 stacking interactions; other site 391595008449 hinge regions; other site 391595008450 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 391595008451 oligomerisation interface [polypeptide binding]; other site 391595008452 mobile loop; other site 391595008453 roof hairpin; other site 391595008454 Uncharacterized conserved protein (DUF2161); Region: DUF2161; pfam09929 391595008455 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 391595008456 DHH family; Region: DHH; pfam01368 391595008457 DHHA2 domain; Region: DHHA2; pfam02833 391595008458 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 391595008459 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595008460 active site 391595008461 motif I; other site 391595008462 motif II; other site 391595008463 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 391595008464 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 391595008465 dimer interaction site [polypeptide binding]; other site 391595008466 substrate-binding tunnel; other site 391595008467 active site 391595008468 catalytic site [active] 391595008469 substrate binding site [chemical binding]; other site 391595008470 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 391595008471 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 391595008472 active site 391595008473 Riboflavin kinase; Region: Flavokinase; pfam01687 391595008474 hypothetical protein; Provisional; Region: PRK05170 391595008475 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 391595008476 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 391595008477 tetramer interface [polypeptide binding]; other site 391595008478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595008479 catalytic residue [active] 391595008480 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391595008481 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 391595008482 catalytic site [active] 391595008483 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 391595008484 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 391595008485 putative catalytic residue [active] 391595008486 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 391595008487 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 391595008488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391595008489 active site 391595008490 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391595008491 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13443 391595008492 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 391595008493 gamma subunit interface [polypeptide binding]; other site 391595008494 epsilon subunit interface [polypeptide binding]; other site 391595008495 LBP interface [polypeptide binding]; other site 391595008496 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 391595008497 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 391595008498 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 391595008499 alpha subunit interaction interface [polypeptide binding]; other site 391595008500 Walker A motif; other site 391595008501 ATP binding site [chemical binding]; other site 391595008502 Walker B motif; other site 391595008503 inhibitor binding site; inhibition site 391595008504 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 391595008505 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 391595008506 core domain interface [polypeptide binding]; other site 391595008507 delta subunit interface [polypeptide binding]; other site 391595008508 epsilon subunit interface [polypeptide binding]; other site 391595008509 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 391595008510 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 391595008511 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 391595008512 beta subunit interaction interface [polypeptide binding]; other site 391595008513 Walker A motif; other site 391595008514 ATP binding site [chemical binding]; other site 391595008515 Walker B motif; other site 391595008516 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 391595008517 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 391595008518 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 391595008519 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391595008520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391595008521 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 391595008522 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 391595008523 Clp amino terminal domain; Region: Clp_N; pfam02861 391595008524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595008525 Walker A motif; other site 391595008526 ATP binding site [chemical binding]; other site 391595008527 Walker B motif; other site 391595008528 arginine finger; other site 391595008529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595008530 Walker A motif; other site 391595008531 ATP binding site [chemical binding]; other site 391595008532 Walker B motif; other site 391595008533 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391595008534 hypothetical protein; Validated; Region: PRK09039 391595008535 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391595008536 ligand binding site [chemical binding]; other site 391595008537 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 391595008538 putative active site pocket [active] 391595008539 dimerization interface [polypeptide binding]; other site 391595008540 putative catalytic residue [active] 391595008541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 391595008542 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 391595008543 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 391595008544 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 391595008545 prephenate dehydrogenase; Validated; Region: PRK08507 391595008546 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 391595008547 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391595008548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595008549 homodimer interface [polypeptide binding]; other site 391595008550 catalytic residue [active] 391595008551 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 391595008552 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 391595008553 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 391595008554 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 391595008555 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391595008556 RNA binding surface [nucleotide binding]; other site 391595008557 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 391595008558 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391595008559 putative acyltransferase; Provisional; Region: PRK05790 391595008560 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391595008561 dimer interface [polypeptide binding]; other site 391595008562 active site 391595008563 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 391595008564 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 391595008565 NAD(P) binding site [chemical binding]; other site 391595008566 homotetramer interface [polypeptide binding]; other site 391595008567 homodimer interface [polypeptide binding]; other site 391595008568 active site 391595008569 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391595008570 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595008571 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595008572 dimerization interface [polypeptide binding]; other site 391595008573 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 391595008574 Methyltransferase domain; Region: Methyltransf_26; pfam13659 391595008575 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 391595008576 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 391595008577 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391595008578 substrate binding pocket [chemical binding]; other site 391595008579 chain length determination region; other site 391595008580 substrate-Mg2+ binding site; other site 391595008581 catalytic residues [active] 391595008582 aspartate-rich region 1; other site 391595008583 active site lid residues [active] 391595008584 aspartate-rich region 2; other site 391595008585 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 391595008586 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 391595008587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595008588 TPR motif; other site 391595008589 binding surface 391595008590 TPR repeat; Region: TPR_11; pfam13414 391595008591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595008592 TPR motif; other site 391595008593 binding surface 391595008594 TPR repeat; Region: TPR_11; pfam13414 391595008595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595008596 binding surface 391595008597 TPR motif; other site 391595008598 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391595008599 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 391595008600 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391595008601 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 391595008602 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 391595008603 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 391595008604 DNA binding residues [nucleotide binding] 391595008605 dimer interface [polypeptide binding]; other site 391595008606 [2Fe-2S] cluster binding site [ion binding]; other site 391595008607 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391595008608 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391595008609 active site 391595008610 metal binding site [ion binding]; metal-binding site 391595008611 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 391595008612 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 391595008613 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 391595008614 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495 391595008615 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK14690 391595008616 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 391595008617 dimer interface [polypeptide binding]; other site 391595008618 putative functional site; other site 391595008619 putative MPT binding site; other site 391595008620 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 391595008621 Walker A motif; other site 391595008622 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 391595008623 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 391595008624 GTP binding site; other site 391595008625 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 391595008626 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 391595008627 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 391595008628 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 391595008629 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391595008630 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391595008631 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391595008632 active site 391595008633 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 391595008634 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 391595008635 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 391595008636 hypothetical protein; Validated; Region: PRK00228 391595008637 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 391595008638 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391595008639 Protein export membrane protein; Region: SecD_SecF; cl14618 391595008640 HlyD family secretion protein; Region: HlyD_3; pfam13437 391595008641 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 391595008642 MPT binding site; other site 391595008643 trimer interface [polypeptide binding]; other site 391595008644 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391595008645 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 391595008646 Fe-S cluster binding site [ion binding]; other site 391595008647 active site 391595008648 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 391595008649 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 391595008650 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 391595008651 dihydroorotase; Validated; Region: PRK09059 391595008652 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 391595008653 active site 391595008654 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 391595008655 Ectoine synthase; Region: Ectoine_synth; pfam06339 391595008656 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391595008657 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391595008658 active site 391595008659 catalytic tetrad [active] 391595008660 Protein of unknown function (DUF938); Region: DUF938; pfam06080 391595008661 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595008662 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391595008663 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391595008664 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595008665 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391595008666 FAD binding domain; Region: FAD_binding_4; pfam01565 391595008667 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 391595008668 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 391595008669 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391595008670 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 391595008671 dimerization interface [polypeptide binding]; other site 391595008672 ligand binding site [chemical binding]; other site 391595008673 NADP binding site [chemical binding]; other site 391595008674 catalytic site [active] 391595008675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 391595008676 Bacterial SH3 domain; Region: SH3_4; pfam06347 391595008677 Bacterial SH3 domain; Region: SH3_4; pfam06347 391595008678 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391595008679 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 391595008680 NAD(P) binding site [chemical binding]; other site 391595008681 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 391595008682 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 391595008683 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 391595008684 cyclase homology domain; Region: CHD; cd07302 391595008685 nucleotidyl binding site; other site 391595008686 metal binding site [ion binding]; metal-binding site 391595008687 dimer interface [polypeptide binding]; other site 391595008688 Predicted integral membrane protein [Function unknown]; Region: COG5616 391595008689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595008690 binding surface 391595008691 TPR motif; other site 391595008692 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 391595008693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391595008694 Coenzyme A binding pocket [chemical binding]; other site 391595008695 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 391595008696 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 391595008697 tetramer interface [polypeptide binding]; other site 391595008698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595008699 catalytic residue [active] 391595008700 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 391595008701 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 391595008702 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 391595008703 cyclase homology domain; Region: CHD; cd07302 391595008704 nucleotidyl binding site; other site 391595008705 metal binding site [ion binding]; metal-binding site 391595008706 dimer interface [polypeptide binding]; other site 391595008707 Predicted integral membrane protein [Function unknown]; Region: COG5616 391595008708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 391595008709 TPR motif; other site 391595008710 binding surface 391595008711 Amino acid synthesis; Region: AA_synth; pfam06684 391595008712 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391595008713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391595008714 Coenzyme A binding pocket [chemical binding]; other site 391595008715 SnoaL-like domain; Region: SnoaL_2; pfam12680 391595008716 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391595008717 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391595008718 DNA binding residues [nucleotide binding] 391595008719 dimerization interface [polypeptide binding]; other site 391595008720 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 391595008721 GAF domain; Region: GAF; pfam01590 391595008722 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391595008723 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391595008724 DNA binding residues [nucleotide binding] 391595008725 dimerization interface [polypeptide binding]; other site 391595008726 Predicted integral membrane protein [Function unknown]; Region: COG5616 391595008727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595008728 TPR motif; other site 391595008729 binding surface 391595008730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595008731 TPR motif; other site 391595008732 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391595008733 binding surface 391595008734 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 391595008735 active site 391595008736 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 391595008737 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 391595008738 additional DNA contacts [nucleotide binding]; other site 391595008739 mismatch recognition site; other site 391595008740 active site 391595008741 zinc binding site [ion binding]; other site 391595008742 DNA intercalation site [nucleotide binding]; other site 391595008743 Homeodomain-like domain; Region: HTH_23; pfam13384 391595008744 Winged helix-turn helix; Region: HTH_29; pfam13551 391595008745 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 391595008746 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 391595008747 cofactor binding site; other site 391595008748 DNA binding site [nucleotide binding] 391595008749 substrate interaction site [chemical binding]; other site 391595008750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 391595008751 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 391595008752 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 391595008753 ParB-like nuclease domain; Region: ParBc; pfam02195 391595008754 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 391595008755 DNA methylase; Region: N6_N4_Mtase; pfam01555 391595008756 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391595008757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595008758 non-specific DNA binding site [nucleotide binding]; other site 391595008759 salt bridge; other site 391595008760 sequence-specific DNA binding site [nucleotide binding]; other site 391595008761 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 391595008762 Phosphotransferase enzyme family; Region: APH; pfam01636 391595008763 active site 391595008764 ATP binding site [chemical binding]; other site 391595008765 substrate binding site [chemical binding]; other site 391595008766 dimer interface [polypeptide binding]; other site 391595008767 Phosphotransferase enzyme family; Region: APH; pfam01636 391595008768 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 391595008769 substrate binding site [chemical binding]; other site 391595008770 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 391595008771 allantoate amidohydrolase; Reviewed; Region: PRK09290 391595008772 active site 391595008773 metal binding site [ion binding]; metal-binding site 391595008774 dimer interface [polypeptide binding]; other site 391595008775 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391595008776 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 391595008777 ligand binding site [chemical binding]; other site 391595008778 regulator interaction site; other site 391595008779 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 391595008780 ANTAR domain; Region: ANTAR; pfam03861 391595008781 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 391595008782 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 391595008783 dimer interface [polypeptide binding]; other site 391595008784 catalytic residues [active] 391595008785 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 391595008786 UreF; Region: UreF; pfam01730 391595008787 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 391595008788 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 391595008789 alpha-gamma subunit interface [polypeptide binding]; other site 391595008790 beta-gamma subunit interface [polypeptide binding]; other site 391595008791 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 391595008792 alpha-beta subunit interface [polypeptide binding]; other site 391595008793 urease subunit alpha; Reviewed; Region: ureC; PRK13308 391595008794 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 391595008795 subunit interactions [polypeptide binding]; other site 391595008796 active site 391595008797 flap region; other site 391595008798 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391595008799 UreD urease accessory protein; Region: UreD; pfam01774 391595008800 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 391595008801 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 391595008802 multimer interface [polypeptide binding]; other site 391595008803 active site 391595008804 catalytic triad [active] 391595008805 dimer interface [polypeptide binding]; other site 391595008806 MoxR-like ATPases [General function prediction only]; Region: COG0714 391595008807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595008808 Walker A motif; other site 391595008809 ATP binding site [chemical binding]; other site 391595008810 Walker B motif; other site 391595008811 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 391595008812 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391595008813 metal ion-dependent adhesion site (MIDAS); other site 391595008814 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 391595008815 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391595008816 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 391595008817 ligand binding site [chemical binding]; other site 391595008818 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595008819 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391595008820 TM-ABC transporter signature motif; other site 391595008821 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391595008822 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391595008823 TM-ABC transporter signature motif; other site 391595008824 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 391595008825 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391595008826 Walker A/P-loop; other site 391595008827 ATP binding site [chemical binding]; other site 391595008828 Q-loop/lid; other site 391595008829 ABC transporter signature motif; other site 391595008830 Walker B; other site 391595008831 D-loop; other site 391595008832 H-loop/switch region; other site 391595008833 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 391595008834 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391595008835 Walker A/P-loop; other site 391595008836 ATP binding site [chemical binding]; other site 391595008837 Q-loop/lid; other site 391595008838 ABC transporter signature motif; other site 391595008839 Walker B; other site 391595008840 D-loop; other site 391595008841 H-loop/switch region; other site 391595008842 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 391595008843 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 391595008844 iron-sulfur cluster [ion binding]; other site 391595008845 [2Fe-2S] cluster binding site [ion binding]; other site 391595008846 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391595008847 hydrophobic ligand binding site; other site 391595008848 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391595008849 Sel1-like repeats; Region: SEL1; smart00671 391595008850 Sel1-like repeats; Region: SEL1; smart00671 391595008851 Sel1-like repeats; Region: SEL1; smart00671 391595008852 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 391595008853 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391595008854 Amidase; Region: Amidase; cl11426 391595008855 ParB-like nuclease domain; Region: ParB; smart00470 391595008856 RepB plasmid partitioning protein; Region: RepB; pfam07506 391595008857 ParB-like nuclease domain; Region: ParB; smart00470 391595008858 RepB plasmid partitioning protein; Region: RepB; pfam07506 391595008859 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391595008860 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 391595008861 catalytic residues [active] 391595008862 catalytic nucleophile [active] 391595008863 Recombinase; Region: Recombinase; pfam07508 391595008864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391595008865 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391595008866 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391595008867 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391595008868 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391595008869 substrate binding pocket [chemical binding]; other site 391595008870 membrane-bound complex binding site; other site 391595008871 hinge residues; other site 391595008872 conserved hypothetical protein; Region: TIGR02231 391595008873 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 391595008874 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 391595008875 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391595008876 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 391595008877 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391595008878 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391595008879 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391595008880 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391595008881 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391595008882 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391595008883 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 391595008884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391595008885 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391595008886 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391595008887 YaeQ protein; Region: YaeQ; cl01913 391595008888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595008889 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595008890 dimerization interface [polypeptide binding]; other site 391595008891 Predicted permease; Region: DUF318; cl17795 391595008892 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595008893 EamA-like transporter family; Region: EamA; pfam00892 391595008894 EamA-like transporter family; Region: EamA; pfam00892 391595008895 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 391595008896 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391595008897 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 391595008898 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391595008899 active site 391595008900 Int/Topo IB signature motif; other site 391595008901 catalytic residues [active] 391595008902 DNA binding site [nucleotide binding] 391595008903 transaminase; Validated; Region: PRK07324 391595008904 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391595008905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595008906 homodimer interface [polypeptide binding]; other site 391595008907 catalytic residue [active] 391595008908 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 391595008909 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 391595008910 homodimer interface [polypeptide binding]; other site 391595008911 substrate-cofactor binding pocket; other site 391595008912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595008913 catalytic residue [active] 391595008914 Uncharacterized conserved protein [Function unknown]; Region: COG2968 391595008915 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 391595008916 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 391595008917 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 391595008918 dimer interface [polypeptide binding]; other site 391595008919 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 391595008920 active site 391595008921 Fe binding site [ion binding]; other site 391595008922 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595008923 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 391595008924 AsnC family; Region: AsnC_trans_reg; pfam01037 391595008925 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 391595008926 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 391595008927 TrkA-N domain; Region: TrkA_N; pfam02254 391595008928 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 391595008929 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 391595008930 putative dimer interface [polypeptide binding]; other site 391595008931 active site pocket [active] 391595008932 putative cataytic base [active] 391595008933 cobalamin synthase; Reviewed; Region: cobS; PRK00235 391595008934 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 391595008935 Ferredoxin [Energy production and conversion]; Region: COG1146 391595008936 4Fe-4S binding domain; Region: Fer4; pfam00037 391595008937 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 391595008938 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391595008939 RNA binding surface [nucleotide binding]; other site 391595008940 DEAD-like helicases superfamily; Region: DEXDc; smart00487 391595008941 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391595008942 ATP binding site [chemical binding]; other site 391595008943 putative Mg++ binding site [ion binding]; other site 391595008944 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391595008945 nucleotide binding region [chemical binding]; other site 391595008946 ATP-binding site [chemical binding]; other site 391595008947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595008948 binding surface 391595008949 TPR repeat; Region: TPR_11; pfam13414 391595008950 TPR motif; other site 391595008951 TPR repeat; Region: TPR_11; pfam13414 391595008952 SCP-2 sterol transfer family; Region: SCP2; pfam02036 391595008953 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 391595008954 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391595008955 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 391595008956 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 391595008957 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391595008958 ATP-dependent DNA ligase; Validated; Region: PRK09247 391595008959 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 391595008960 active site 391595008961 DNA binding site [nucleotide binding] 391595008962 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 391595008963 DNA binding site [nucleotide binding] 391595008964 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 391595008965 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 391595008966 active site 391595008967 Zn binding site [ion binding]; other site 391595008968 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 391595008969 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 391595008970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391595008971 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391595008972 DNA binding residues [nucleotide binding] 391595008973 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 391595008974 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391595008975 RNA binding surface [nucleotide binding]; other site 391595008976 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 391595008977 active site 391595008978 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 391595008979 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391595008980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595008981 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391595008982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391595008983 Coenzyme A binding pocket [chemical binding]; other site 391595008984 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 391595008985 transcription antitermination factor NusB; Region: nusB; TIGR01951 391595008986 putative RNA binding site [nucleotide binding]; other site 391595008987 6,7-dimethyl-8-ribityllumazine synthase; Provisional; Region: ribH; PRK00061 391595008988 active site 391595008989 homopentamer interface [polypeptide binding]; other site 391595008990 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 391595008991 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 391595008992 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 391595008993 dimerization interface [polypeptide binding]; other site 391595008994 active site 391595008995 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 391595008996 Lumazine binding domain; Region: Lum_binding; pfam00677 391595008997 Lumazine binding domain; Region: Lum_binding; pfam00677 391595008998 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 391595008999 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 391595009000 catalytic motif [active] 391595009001 Zn binding site [ion binding]; other site 391595009002 RibD C-terminal domain; Region: RibD_C; cl17279 391595009003 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 391595009004 ATP cone domain; Region: ATP-cone; pfam03477 391595009005 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 391595009006 Transcriptional activator HlyU; Region: HlyU; pfam10115 391595009007 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 391595009008 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 391595009009 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 391595009010 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 391595009011 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391595009012 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 391595009013 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391595009014 DNA binding residues [nucleotide binding] 391595009015 DNA primase, catalytic core; Region: dnaG; TIGR01391 391595009016 CHC2 zinc finger; Region: zf-CHC2; cl17510 391595009017 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 391595009018 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 391595009019 active site 391595009020 metal binding site [ion binding]; metal-binding site 391595009021 interdomain interaction site; other site 391595009022 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 391595009023 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391595009024 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391595009025 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 391595009026 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391595009027 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595009028 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 391595009029 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 391595009030 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391595009031 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 391595009032 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 391595009033 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 391595009034 NAD(P) binding site [chemical binding]; other site 391595009035 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 391595009036 GTP-binding protein Der; Reviewed; Region: PRK00093 391595009037 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 391595009038 G1 box; other site 391595009039 GTP/Mg2+ binding site [chemical binding]; other site 391595009040 Switch I region; other site 391595009041 G2 box; other site 391595009042 Switch II region; other site 391595009043 G3 box; other site 391595009044 G4 box; other site 391595009045 G5 box; other site 391595009046 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 391595009047 G1 box; other site 391595009048 GTP/Mg2+ binding site [chemical binding]; other site 391595009049 Switch I region; other site 391595009050 G2 box; other site 391595009051 G3 box; other site 391595009052 Switch II region; other site 391595009053 G4 box; other site 391595009054 G5 box; other site 391595009055 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 391595009056 Trp docking motif [polypeptide binding]; other site 391595009057 active site 391595009058 PQQ-like domain; Region: PQQ_2; pfam13360 391595009059 PQQ-like domain; Region: PQQ_2; pfam13360 391595009060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 391595009061 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391595009062 HlyD family secretion protein; Region: HlyD_3; pfam13437 391595009063 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391595009064 Protein export membrane protein; Region: SecD_SecF; cl14618 391595009065 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391595009066 Domain of unknown function DUF302; Region: DUF302; pfam03625 391595009067 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391595009068 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595009069 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 391595009070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595009071 Walker A/P-loop; other site 391595009072 ATP binding site [chemical binding]; other site 391595009073 Q-loop/lid; other site 391595009074 ABC transporter signature motif; other site 391595009075 Walker B; other site 391595009076 D-loop; other site 391595009077 H-loop/switch region; other site 391595009078 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 391595009079 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 391595009080 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 391595009081 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 391595009082 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 391595009083 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 391595009084 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 391595009085 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 391595009086 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 391595009087 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595009088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595009089 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 391595009090 putative dimerization interface [polypeptide binding]; other site 391595009091 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 391595009092 FAD binding site [chemical binding]; other site 391595009093 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391595009094 CoenzymeA binding site [chemical binding]; other site 391595009095 subunit interaction site [polypeptide binding]; other site 391595009096 PHB binding site; other site 391595009097 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 391595009098 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391595009099 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391595009100 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391595009101 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 391595009102 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341 391595009103 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 391595009104 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391595009105 active site 391595009106 HIGH motif; other site 391595009107 nucleotide binding site [chemical binding]; other site 391595009108 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 391595009109 active site 391595009110 KMSKS motif; other site 391595009111 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 391595009112 tRNA binding surface [nucleotide binding]; other site 391595009113 anticodon binding site; other site 391595009114 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 391595009115 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 391595009116 enoyl-CoA hydratase; Provisional; Region: PRK07509 391595009117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391595009118 substrate binding site [chemical binding]; other site 391595009119 oxyanion hole (OAH) forming residues; other site 391595009120 trimer interface [polypeptide binding]; other site 391595009121 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 391595009122 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391595009123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595009124 homodimer interface [polypeptide binding]; other site 391595009125 catalytic residue [active] 391595009126 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 391595009127 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 391595009128 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595009129 catalytic residue [active] 391595009130 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391595009131 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595009132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595009133 Walker A/P-loop; other site 391595009134 ATP binding site [chemical binding]; other site 391595009135 Q-loop/lid; other site 391595009136 ABC transporter signature motif; other site 391595009137 Walker B; other site 391595009138 D-loop; other site 391595009139 H-loop/switch region; other site 391595009140 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 391595009141 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 391595009142 Probable Catalytic site; other site 391595009143 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 391595009144 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 391595009145 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595009146 elongation factor P; Validated; Region: PRK00529 391595009147 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 391595009148 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 391595009149 RNA binding site [nucleotide binding]; other site 391595009150 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 391595009151 RNA binding site [nucleotide binding]; other site 391595009152 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 391595009153 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 391595009154 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 391595009155 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391595009156 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 391595009157 Walker A/P-loop; other site 391595009158 ATP binding site [chemical binding]; other site 391595009159 Q-loop/lid; other site 391595009160 ABC transporter signature motif; other site 391595009161 Walker B; other site 391595009162 D-loop; other site 391595009163 H-loop/switch region; other site 391595009164 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391595009165 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 391595009166 FtsX-like permease family; Region: FtsX; pfam02687 391595009167 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 391595009168 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 391595009169 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595009170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595009171 Walker A/P-loop; other site 391595009172 ATP binding site [chemical binding]; other site 391595009173 Q-loop/lid; other site 391595009174 ABC transporter signature motif; other site 391595009175 Walker B; other site 391595009176 D-loop; other site 391595009177 H-loop/switch region; other site 391595009178 TOBE domain; Region: TOBE_2; pfam08402 391595009179 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595009180 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595009181 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595009182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595009183 dimer interface [polypeptide binding]; other site 391595009184 conserved gate region; other site 391595009185 putative PBP binding loops; other site 391595009186 ABC-ATPase subunit interface; other site 391595009187 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 391595009188 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595009189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391595009190 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 391595009191 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391595009192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595009193 DNA-binding site [nucleotide binding]; DNA binding site 391595009194 UTRA domain; Region: UTRA; pfam07702 391595009195 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 391595009196 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 391595009197 dimer interface [polypeptide binding]; other site 391595009198 active site 391595009199 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 391595009200 dimer interface [polypeptide binding]; other site 391595009201 active site 391595009202 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595009203 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 391595009204 active site 391595009205 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 391595009206 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 391595009207 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391595009208 HlyD family secretion protein; Region: HlyD_3; pfam13437 391595009209 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 391595009210 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595009211 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 391595009212 Walker A/P-loop; other site 391595009213 ATP binding site [chemical binding]; other site 391595009214 Q-loop/lid; other site 391595009215 ABC transporter signature motif; other site 391595009216 Walker B; other site 391595009217 D-loop; other site 391595009218 H-loop/switch region; other site 391595009219 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595009220 DNA-binding site [nucleotide binding]; DNA binding site 391595009221 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 391595009222 UTRA domain; Region: UTRA; pfam07702 391595009223 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 391595009224 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595009225 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391595009226 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391595009227 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391595009228 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 391595009229 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391595009230 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391595009231 active site 391595009232 PAS domain; Region: PAS_9; pfam13426 391595009233 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391595009234 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391595009235 metal binding site [ion binding]; metal-binding site 391595009236 active site 391595009237 I-site; other site 391595009238 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391595009239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595009240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391595009241 putative substrate translocation pore; other site 391595009242 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391595009243 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391595009244 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 391595009245 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 391595009246 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595009247 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 391595009248 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 391595009249 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391595009250 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391595009251 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391595009252 conserved cys residue [active] 391595009253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595009254 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 391595009255 Bacterial sugar transferase; Region: Bac_transf; pfam02397 391595009256 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 391595009257 putative active site [active] 391595009258 catalytic site [active] 391595009259 putative metal binding site [ion binding]; other site 391595009260 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 391595009261 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 391595009262 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595009263 FeS/SAM binding site; other site 391595009264 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 391595009265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595009266 FeS/SAM binding site; other site 391595009267 HemN C-terminal domain; Region: HemN_C; pfam06969 391595009268 NnrU protein; Region: NnrU; pfam07298 391595009269 NnrS protein; Region: NnrS; pfam05940 391595009270 Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534 391595009271 Transcriptional regulator; Region: Rrf2; cl17282 391595009272 Rrf2 family protein; Region: rrf2_super; TIGR00738 391595009273 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 391595009274 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 391595009275 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 391595009276 TrkA-N domain; Region: TrkA_N; pfam02254 391595009277 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 391595009278 Maf-like protein; Region: Maf; pfam02545 391595009279 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 391595009280 active site 391595009281 dimer interface [polypeptide binding]; other site 391595009282 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 391595009283 rRNA binding site [nucleotide binding]; other site 391595009284 predicted 30S ribosome binding site; other site 391595009285 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 391595009286 Predicted amidohydrolase [General function prediction only]; Region: COG0388 391595009287 putative active site [active] 391595009288 catalytic triad [active] 391595009289 putative dimer interface [polypeptide binding]; other site 391595009290 NAD-dependent deacetylase; Provisional; Region: PRK00481 391595009291 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 391595009292 NAD+ binding site [chemical binding]; other site 391595009293 substrate binding site [chemical binding]; other site 391595009294 Zn binding site [ion binding]; other site 391595009295 Protein of unknown function (DUF461); Region: DUF461; pfam04314 391595009296 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 391595009297 membrane ATPase/protein kinase; Provisional; Region: PRK09435 391595009298 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 391595009299 Walker A; other site 391595009300 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 391595009301 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391595009302 ATP binding site [chemical binding]; other site 391595009303 putative Mg++ binding site [ion binding]; other site 391595009304 helicase superfamily c-terminal domain; Region: HELICc; smart00490 391595009305 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 391595009306 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 391595009307 ornithine carbamoyltransferase; Provisional; Region: PRK00779 391595009308 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 391595009309 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 391595009310 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 391595009311 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391595009312 inhibitor-cofactor binding pocket; inhibition site 391595009313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595009314 catalytic residue [active] 391595009315 GcrA cell cycle regulator; Region: GcrA; cl11564 391595009316 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 391595009317 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391595009318 PYR/PP interface [polypeptide binding]; other site 391595009319 dimer interface [polypeptide binding]; other site 391595009320 TPP binding site [chemical binding]; other site 391595009321 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391595009322 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391595009323 TPP-binding site [chemical binding]; other site 391595009324 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391595009325 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391595009326 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 391595009327 OpgC protein; Region: OpgC_C; pfam10129 391595009328 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 391595009329 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 391595009330 glucosyltransferase MdoH; Provisional; Region: PRK05454 391595009331 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 391595009332 active site 391595009333 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391595009334 active site residue [active] 391595009335 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 391595009336 putative uracil binding site [chemical binding]; other site 391595009337 putative active site [active] 391595009338 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 391595009339 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 391595009340 AsmA family; Region: AsmA; pfam05170 391595009341 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 391595009342 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 391595009343 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391595009344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595009345 FeS/SAM binding site; other site 391595009346 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 391595009347 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 391595009348 Protein of unknown function, DUF393; Region: DUF393; pfam04134 391595009349 Peptidase family M48; Region: Peptidase_M48; cl12018 391595009350 aminotransferase; Provisional; Region: PRK13356 391595009351 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391595009352 homodimer interface [polypeptide binding]; other site 391595009353 substrate-cofactor binding pocket; other site 391595009354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595009355 catalytic residue [active] 391595009356 Sensors of blue-light using FAD; Region: BLUF; pfam04940 391595009357 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391595009358 Ligand Binding Site [chemical binding]; other site 391595009359 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 391595009360 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 391595009361 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 391595009362 Glycoprotease family; Region: Peptidase_M22; pfam00814 391595009363 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 391595009364 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391595009365 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391595009366 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 391595009367 ligand binding site [chemical binding]; other site 391595009368 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391595009369 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391595009370 Walker A/P-loop; other site 391595009371 ATP binding site [chemical binding]; other site 391595009372 Q-loop/lid; other site 391595009373 ABC transporter signature motif; other site 391595009374 Walker B; other site 391595009375 D-loop; other site 391595009376 H-loop/switch region; other site 391595009377 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391595009378 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391595009379 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595009380 TM-ABC transporter signature motif; other site 391595009381 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595009382 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391595009383 TM-ABC transporter signature motif; other site 391595009384 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391595009385 hypothetical protein; Provisional; Region: PRK10621 391595009386 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 391595009387 AAA domain; Region: AAA_30; pfam13604 391595009388 Family description; Region: UvrD_C_2; pfam13538 391595009389 Autoinducer synthetase; Region: Autoind_synth; cl17404 391595009390 Autoinducer binding domain; Region: Autoind_bind; pfam03472 391595009391 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391595009392 DNA binding residues [nucleotide binding] 391595009393 dimerization interface [polypeptide binding]; other site 391595009394 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 391595009395 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 391595009396 putative NAD(P) binding site [chemical binding]; other site 391595009397 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 391595009398 putative acyl-acceptor binding pocket; other site 391595009399 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 391595009400 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 391595009401 B12 binding site [chemical binding]; other site 391595009402 cobalt ligand [ion binding]; other site 391595009403 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 391595009404 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 391595009405 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 391595009406 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 391595009407 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 391595009408 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 391595009409 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 391595009410 L-aspartate oxidase; Provisional; Region: PRK06175 391595009411 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 391595009412 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 391595009413 putative SdhC subunit interface [polypeptide binding]; other site 391595009414 putative proximal heme binding site [chemical binding]; other site 391595009415 putative Iron-sulfur protein interface [polypeptide binding]; other site 391595009416 putative proximal quinone binding site; other site 391595009417 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 391595009418 Iron-sulfur protein interface; other site 391595009419 proximal quinone binding site [chemical binding]; other site 391595009420 SdhD (CybS) interface [polypeptide binding]; other site 391595009421 proximal heme binding site [chemical binding]; other site 391595009422 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 391595009423 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 391595009424 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 391595009425 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 391595009426 putative active site [active] 391595009427 putative catalytic site [active] 391595009428 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 391595009429 putative active site [active] 391595009430 putative catalytic site [active] 391595009431 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 391595009432 NnrU protein; Region: NnrU; pfam07298 391595009433 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 391595009434 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391595009435 malate dehydrogenase; Reviewed; Region: PRK06223 391595009436 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 391595009437 NAD(P) binding site [chemical binding]; other site 391595009438 dimer interface [polypeptide binding]; other site 391595009439 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391595009440 substrate binding site [chemical binding]; other site 391595009441 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 391595009442 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 391595009443 CoA-ligase; Region: Ligase_CoA; pfam00549 391595009444 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 391595009445 CoA binding domain; Region: CoA_binding; pfam02629 391595009446 CoA-ligase; Region: Ligase_CoA; pfam00549 391595009447 Protein of unknown function (DUF805); Region: DUF805; pfam05656 391595009448 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 391595009449 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 391595009450 TPP-binding site [chemical binding]; other site 391595009451 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 391595009452 dimer interface [polypeptide binding]; other site 391595009453 PYR/PP interface [polypeptide binding]; other site 391595009454 TPP binding site [chemical binding]; other site 391595009455 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391595009456 E3 interaction surface; other site 391595009457 lipoyl attachment site [posttranslational modification]; other site 391595009458 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 391595009459 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391595009460 E3 interaction surface; other site 391595009461 lipoyl attachment site [posttranslational modification]; other site 391595009462 e3 binding domain; Region: E3_binding; pfam02817 391595009463 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391595009464 MAPEG family; Region: MAPEG; cl09190 391595009465 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391595009466 phosphate binding site [ion binding]; other site 391595009467 MAPEG family; Region: MAPEG; pfam01124 391595009468 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 391595009469 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 391595009470 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391595009471 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391595009472 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 391595009473 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391595009474 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391595009475 putative acyl-acceptor binding pocket; other site 391595009476 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 391595009477 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 391595009478 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391595009479 Walker A/P-loop; other site 391595009480 ATP binding site [chemical binding]; other site 391595009481 Q-loop/lid; other site 391595009482 ABC transporter signature motif; other site 391595009483 Walker B; other site 391595009484 D-loop; other site 391595009485 H-loop/switch region; other site 391595009486 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 391595009487 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 391595009488 diaminopimelate decarboxylase; Region: lysA; TIGR01048 391595009489 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 391595009490 active site 391595009491 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391595009492 substrate binding site [chemical binding]; other site 391595009493 catalytic residues [active] 391595009494 dimer interface [polypeptide binding]; other site 391595009495 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 391595009496 argininosuccinate lyase; Provisional; Region: PRK00855 391595009497 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 391595009498 active sites [active] 391595009499 tetramer interface [polypeptide binding]; other site 391595009500 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 391595009501 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391595009502 catalytic residues [active] 391595009503 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391595009504 putative metal binding site [ion binding]; other site 391595009505 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391595009506 putative catalytic site [active] 391595009507 putative phosphate binding site [ion binding]; other site 391595009508 putative metal binding site [ion binding]; other site 391595009509 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391595009510 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391595009511 HlyD family secretion protein; Region: HlyD_3; pfam13437 391595009512 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391595009513 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391595009514 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391595009515 active site 391595009516 catalytic tetrad [active] 391595009517 PKD domain; Region: PKD; pfam00801 391595009518 VCBS repeat; Region: VCBS_repeat; TIGR01965 391595009519 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 391595009520 DctM-like transporters; Region: DctM; pfam06808 391595009521 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391595009522 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 391595009523 choline dehydrogenase; Validated; Region: PRK02106 391595009524 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391595009525 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391595009526 active site 391595009527 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391595009528 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 391595009529 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 391595009530 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391595009531 active site 391595009532 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 391595009533 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 391595009534 substrate-cofactor binding pocket; other site 391595009535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595009536 catalytic residue [active] 391595009537 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 391595009538 active site 391595009539 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 391595009540 putative active site [active] 391595009541 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 391595009542 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 391595009543 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 391595009544 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 391595009545 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 391595009546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595009547 FeS/SAM binding site; other site 391595009548 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 391595009549 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595009550 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595009551 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595009552 putative DNA binding site [nucleotide binding]; other site 391595009553 putative Zn2+ binding site [ion binding]; other site 391595009554 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595009555 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595009556 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 391595009557 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 391595009558 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 391595009559 active site 391595009560 SAM binding site [chemical binding]; other site 391595009561 homodimer interface [polypeptide binding]; other site 391595009562 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 391595009563 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 391595009564 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 391595009565 FMN-binding domain; Region: FMN_bind; cl01081 391595009566 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 391595009567 4Fe-4S binding domain; Region: Fer4_5; pfam12801 391595009568 4Fe-4S binding domain; Region: Fer4_5; pfam12801 391595009569 Cytochrome c2 [Energy production and conversion]; Region: COG3474 391595009570 Cytochrome c; Region: Cytochrom_C; pfam00034 391595009571 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 391595009572 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 391595009573 Binuclear center (active site) [active] 391595009574 K-pathway; other site 391595009575 Putative proton exit pathway; other site 391595009576 MoxR-like ATPases [General function prediction only]; Region: COG0714 391595009577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595009578 Walker A motif; other site 391595009579 ATP binding site [chemical binding]; other site 391595009580 Walker B motif; other site 391595009581 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 391595009582 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 391595009583 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 391595009584 metal ion-dependent adhesion site (MIDAS); other site 391595009585 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 391595009586 Subunit I/III interface [polypeptide binding]; other site 391595009587 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 391595009588 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391595009589 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595009590 ligand binding site [chemical binding]; other site 391595009591 flexible hinge region; other site 391595009592 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 391595009593 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391595009594 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595009595 ligand binding site [chemical binding]; other site 391595009596 flexible hinge region; other site 391595009597 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391595009598 putative switch regulator; other site 391595009599 non-specific DNA interactions [nucleotide binding]; other site 391595009600 DNA binding site [nucleotide binding] 391595009601 sequence specific DNA binding site [nucleotide binding]; other site 391595009602 putative cAMP binding site [chemical binding]; other site 391595009603 ApbE family; Region: ApbE; pfam02424 391595009604 NosL; Region: NosL; pfam05573 391595009605 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 391595009606 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391595009607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595009608 Walker A/P-loop; other site 391595009609 ATP binding site [chemical binding]; other site 391595009610 Q-loop/lid; other site 391595009611 ABC transporter signature motif; other site 391595009612 Walker B; other site 391595009613 D-loop; other site 391595009614 H-loop/switch region; other site 391595009615 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 391595009616 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 391595009617 nitrous-oxide reductase; Validated; Region: PRK02888 391595009618 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 391595009619 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 391595009620 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 391595009621 4Fe-4S binding domain; Region: Fer4_5; pfam12801 391595009622 4Fe-4S binding domain; Region: Fer4_5; pfam12801 391595009623 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595009624 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595009625 DctM-like transporters; Region: DctM; pfam06808 391595009626 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391595009627 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391595009628 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391595009629 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595009630 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391595009631 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 391595009632 FAD binding pocket [chemical binding]; other site 391595009633 FAD binding motif [chemical binding]; other site 391595009634 phosphate binding motif [ion binding]; other site 391595009635 beta-alpha-beta structure motif; other site 391595009636 NAD binding pocket [chemical binding]; other site 391595009637 Amino acid synthesis; Region: AA_synth; pfam06684 391595009638 Amino acid synthesis; Region: AA_synth; pfam06684 391595009639 hypothetical protein; Provisional; Region: PRK04334 391595009640 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391595009641 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111 391595009642 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391595009643 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391595009644 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391595009645 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391595009646 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 391595009647 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 391595009648 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391595009649 MarR family; Region: MarR_2; pfam12802 391595009650 Amidohydrolase; Region: Amidohydro_5; pfam13594 391595009651 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 391595009652 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 391595009653 active site 391595009654 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595009655 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 391595009656 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391595009657 active site 391595009658 thymidine phosphorylase; Provisional; Region: PRK04350 391595009659 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391595009660 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 391595009661 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 391595009662 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 391595009663 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 391595009664 dimerization interface [polypeptide binding]; other site 391595009665 active site 391595009666 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 391595009667 DctM-like transporters; Region: DctM; pfam06808 391595009668 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391595009669 FRG domain; Region: FRG; pfam08867 391595009670 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391595009671 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595009672 ligand binding site [chemical binding]; other site 391595009673 flexible hinge region; other site 391595009674 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391595009675 putative switch regulator; other site 391595009676 non-specific DNA interactions [nucleotide binding]; other site 391595009677 DNA binding site [nucleotide binding] 391595009678 sequence specific DNA binding site [nucleotide binding]; other site 391595009679 putative cAMP binding site [chemical binding]; other site 391595009680 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391595009681 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391595009682 Sulphur transport; Region: Sulf_transp; pfam04143 391595009683 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 391595009684 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 391595009685 Cytochrome c2 [Energy production and conversion]; Region: COG3474 391595009686 Cytochrome c; Region: Cytochrom_C; cl11414 391595009687 Cytochrome c; Region: Cytochrom_C; pfam00034 391595009688 Cytochrome c2 [Energy production and conversion]; Region: COG3474 391595009689 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 391595009690 Moco binding site; other site 391595009691 metal coordination site [ion binding]; other site 391595009692 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 391595009693 active site 391595009694 metal binding site [ion binding]; metal-binding site 391595009695 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 391595009696 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 391595009697 Cytochrome c [Energy production and conversion]; Region: COG3258 391595009698 Cytochrome c [Energy production and conversion]; Region: COG3258 391595009699 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 391595009700 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 391595009701 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 391595009702 Cytochrome c; Region: Cytochrom_C; pfam00034 391595009703 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 391595009704 catalytic residues [active] 391595009705 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 391595009706 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 391595009707 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391595009708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595009709 dimerization interface [polypeptide binding]; other site 391595009710 putative DNA binding site [nucleotide binding]; other site 391595009711 putative Zn2+ binding site [ion binding]; other site 391595009712 Sulphur transport; Region: Sulf_transp; pfam04143 391595009713 Uncharacterized conserved protein [Function unknown]; Region: COG3777 391595009714 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391595009715 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391595009716 active site 1 [active] 391595009717 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 391595009718 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391595009719 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391595009720 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391595009721 TM-ABC transporter signature motif; other site 391595009722 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391595009723 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595009724 TM-ABC transporter signature motif; other site 391595009725 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391595009726 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391595009727 Walker A/P-loop; other site 391595009728 ATP binding site [chemical binding]; other site 391595009729 Q-loop/lid; other site 391595009730 ABC transporter signature motif; other site 391595009731 Walker B; other site 391595009732 D-loop; other site 391595009733 H-loop/switch region; other site 391595009734 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391595009735 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 391595009736 ligand binding site [chemical binding]; other site 391595009737 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391595009738 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391595009739 Walker A/P-loop; other site 391595009740 ATP binding site [chemical binding]; other site 391595009741 Q-loop/lid; other site 391595009742 ABC transporter signature motif; other site 391595009743 Walker B; other site 391595009744 D-loop; other site 391595009745 H-loop/switch region; other site 391595009746 Isochorismatase family; Region: Isochorismatase; pfam00857 391595009747 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 391595009748 catalytic triad [active] 391595009749 conserved cis-peptide bond; other site 391595009750 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391595009751 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391595009752 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 391595009753 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 391595009754 putative active site [active] 391595009755 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391595009756 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391595009757 Predicted amidohydrolase [General function prediction only]; Region: COG0388 391595009758 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 391595009759 putative active site [active] 391595009760 catalytic triad [active] 391595009761 putative dimer interface [polypeptide binding]; other site 391595009762 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 391595009763 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 391595009764 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 391595009765 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 391595009766 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 391595009767 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 391595009768 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391595009769 ATP binding site [chemical binding]; other site 391595009770 putative Mg++ binding site [ion binding]; other site 391595009771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391595009772 nucleotide binding region [chemical binding]; other site 391595009773 ATP-binding site [chemical binding]; other site 391595009774 Part of AAA domain; Region: AAA_19; pfam13245 391595009775 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 391595009776 Family description; Region: UvrD_C_2; pfam13538 391595009777 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 391595009778 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391595009779 active site 391595009780 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391595009781 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 391595009782 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 391595009783 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 391595009784 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 391595009785 Domain of unknown function DUF20; Region: UPF0118; pfam01594 391595009786 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391595009787 putative catalytic site [active] 391595009788 putative metal binding site [ion binding]; other site 391595009789 putative phosphate binding site [ion binding]; other site 391595009790 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 391595009791 G8 domain; Region: G8; pfam10162 391595009792 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391595009793 Predicted thioesterase [General function prediction only]; Region: COG5496 391595009794 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595009795 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595009796 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 391595009797 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391595009798 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391595009799 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391595009800 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 391595009801 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 391595009802 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391595009803 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 391595009804 dimer interface [polypeptide binding]; other site 391595009805 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391595009806 putative metal binding site [ion binding]; other site 391595009807 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595009808 sequence-specific DNA binding site [nucleotide binding]; other site 391595009809 salt bridge; other site 391595009810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595009811 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391595009812 putative substrate translocation pore; other site 391595009813 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 391595009814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391595009815 Coenzyme A binding pocket [chemical binding]; other site 391595009816 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 391595009817 active site 391595009818 hydrophilic channel; other site 391595009819 dimerization interface [polypeptide binding]; other site 391595009820 catalytic residues [active] 391595009821 active site lid [active] 391595009822 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 391595009823 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391595009824 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391595009825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595009826 homodimer interface [polypeptide binding]; other site 391595009827 catalytic residue [active] 391595009828 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 391595009829 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 391595009830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 391595009831 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391595009832 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391595009833 EamA-like transporter family; Region: EamA; pfam00892 391595009834 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391595009835 TPP-binding site [chemical binding]; other site 391595009836 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 391595009837 PYR/PP interface [polypeptide binding]; other site 391595009838 dimer interface [polypeptide binding]; other site 391595009839 TPP binding site [chemical binding]; other site 391595009840 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391595009841 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 391595009842 tetramer interface [polypeptide binding]; other site 391595009843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595009844 catalytic residue [active] 391595009845 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391595009846 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595009847 putative DNA binding site [nucleotide binding]; other site 391595009848 putative Zn2+ binding site [ion binding]; other site 391595009849 AsnC family; Region: AsnC_trans_reg; pfam01037 391595009850 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391595009851 Transposase; Region: HTH_Tnp_1; cl17663 391595009852 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 391595009853 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 391595009854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595009855 AAA domain; Region: AAA_33; pfam13671 391595009856 AAA domain; Region: AAA_17; pfam13207 391595009857 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 391595009858 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 391595009859 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 391595009860 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 391595009861 Survival protein SurE; Region: SurE; cl00448 391595009862 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391595009863 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595009864 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595009865 Walker A/P-loop; other site 391595009866 ATP binding site [chemical binding]; other site 391595009867 Q-loop/lid; other site 391595009868 ABC transporter signature motif; other site 391595009869 Walker B; other site 391595009870 D-loop; other site 391595009871 H-loop/switch region; other site 391595009872 TOBE domain; Region: TOBE_2; pfam08402 391595009873 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 391595009874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595009875 dimer interface [polypeptide binding]; other site 391595009876 conserved gate region; other site 391595009877 putative PBP binding loops; other site 391595009878 ABC-ATPase subunit interface; other site 391595009879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595009880 dimer interface [polypeptide binding]; other site 391595009881 conserved gate region; other site 391595009882 putative PBP binding loops; other site 391595009883 ABC-ATPase subunit interface; other site 391595009884 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391595009885 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391595009886 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391595009887 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 391595009888 E3 interaction surface; other site 391595009889 lipoyl attachment site [posttranslational modification]; other site 391595009890 e3 binding domain; Region: E3_binding; pfam02817 391595009891 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391595009892 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 391595009893 catalytic site [active] 391595009894 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391595009895 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391595009896 alpha subunit interface [polypeptide binding]; other site 391595009897 TPP binding site [chemical binding]; other site 391595009898 heterodimer interface [polypeptide binding]; other site 391595009899 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391595009900 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 391595009901 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391595009902 tetramer interface [polypeptide binding]; other site 391595009903 TPP-binding site [chemical binding]; other site 391595009904 heterodimer interface [polypeptide binding]; other site 391595009905 phosphorylation loop region [posttranslational modification] 391595009906 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 391595009907 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 391595009908 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 391595009909 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391595009910 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595009911 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 391595009912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595009913 dimer interface [polypeptide binding]; other site 391595009914 conserved gate region; other site 391595009915 putative PBP binding loops; other site 391595009916 ABC-ATPase subunit interface; other site 391595009917 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595009918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595009919 dimer interface [polypeptide binding]; other site 391595009920 conserved gate region; other site 391595009921 putative PBP binding loops; other site 391595009922 ABC-ATPase subunit interface; other site 391595009923 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595009924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595009925 Walker A/P-loop; other site 391595009926 ATP binding site [chemical binding]; other site 391595009927 Q-loop/lid; other site 391595009928 ABC transporter signature motif; other site 391595009929 Walker B; other site 391595009930 D-loop; other site 391595009931 H-loop/switch region; other site 391595009932 TOBE domain; Region: TOBE_2; pfam08402 391595009933 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391595009934 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391595009935 ATP binding site [chemical binding]; other site 391595009936 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 391595009937 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391595009938 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391595009939 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391595009940 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391595009941 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 391595009942 catalytic residues [active] 391595009943 catalytic nucleophile [active] 391595009944 Recombinase; Region: Recombinase; pfam07508 391595009945 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 391595009946 Recombinase; Region: Recombinase; pfam07508 391595009947 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 391595009948 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 391595009949 putative active site [active] 391595009950 putative catalytic site [active] 391595009951 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391595009952 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 391595009953 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595009954 active site 391595009955 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391595009956 NMT1/THI5 like; Region: NMT1; pfam09084 391595009957 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391595009958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595009959 dimer interface [polypeptide binding]; other site 391595009960 conserved gate region; other site 391595009961 putative PBP binding loops; other site 391595009962 ABC-ATPase subunit interface; other site 391595009963 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391595009964 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391595009965 Walker A/P-loop; other site 391595009966 ATP binding site [chemical binding]; other site 391595009967 Q-loop/lid; other site 391595009968 ABC transporter signature motif; other site 391595009969 Walker B; other site 391595009970 D-loop; other site 391595009971 H-loop/switch region; other site 391595009972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595009973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595009974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391595009975 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391595009976 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391595009977 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595009978 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595009979 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595009980 dimerization interface [polypeptide binding]; other site 391595009981 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 391595009982 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391595009983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 391595009984 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 391595009985 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391595009986 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391595009987 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 391595009988 active site 391595009989 homotetramer interface [polypeptide binding]; other site 391595009990 Staphylococcal nuclease homologues; Region: SNc; smart00318 391595009991 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 391595009992 Catalytic site; other site 391595009993 Domain of unknown function DUF302; Region: DUF302; pfam03625 391595009994 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 391595009995 Predicted integral membrane protein [Function unknown]; Region: COG5616 391595009996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595009997 TPR motif; other site 391595009998 TPR repeat; Region: TPR_11; pfam13414 391595009999 binding surface 391595010000 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 391595010001 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391595010002 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391595010003 dimer interface [polypeptide binding]; other site 391595010004 putative CheW interface [polypeptide binding]; other site 391595010005 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 391595010006 DNA methylase; Region: N6_N4_Mtase; cl17433 391595010007 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391595010008 Transposase; Region: HTH_Tnp_1; cl17663 391595010009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391595010010 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391595010011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391595010012 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391595010013 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391595010014 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391595010015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391595010016 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 391595010017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595010018 ATP binding site [chemical binding]; other site 391595010019 Mg2+ binding site [ion binding]; other site 391595010020 G-X-G motif; other site 391595010021 mercuric reductase; Validated; Region: PRK06370 391595010022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595010023 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391595010024 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391595010025 Uncharacterized conserved protein [Function unknown]; Region: COG0398 391595010026 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 391595010027 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 391595010028 Ribonuclease P; Region: Ribonuclease_P; pfam00825 391595010029 Haemolytic domain; Region: Haemolytic; pfam01809 391595010030 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 391595010031 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 391595010032 Ligand Binding Site [chemical binding]; other site 391595010033 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391595010034 metal binding site [ion binding]; metal-binding site 391595010035 active site 391595010036 I-site; other site 391595010037 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391595010038 membrane protein insertase; Provisional; Region: PRK01318 391595010039 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 391595010040 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 391595010041 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 391595010042 MOSC domain; Region: MOSC; pfam03473 391595010043 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 391595010044 G1 box; other site 391595010045 GTP/Mg2+ binding site [chemical binding]; other site 391595010046 Switch I region; other site 391595010047 G2 box; other site 391595010048 G3 box; other site 391595010049 Switch II region; other site 391595010050 G4 box; other site 391595010051 G5 box; other site 391595010052 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 391595010053 feedback inhibition sensing region; other site 391595010054 homohexameric interface [polypeptide binding]; other site 391595010055 nucleotide binding site [chemical binding]; other site 391595010056 N-acetyl-L-glutamate binding site [chemical binding]; other site 391595010057 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 391595010058 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 391595010059 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391595010060 catalytic core [active] 391595010061 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391595010062 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391595010063 Walker A/P-loop; other site 391595010064 ATP binding site [chemical binding]; other site 391595010065 Q-loop/lid; other site 391595010066 ABC transporter signature motif; other site 391595010067 Walker B; other site 391595010068 D-loop; other site 391595010069 H-loop/switch region; other site 391595010070 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391595010071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595010072 dimer interface [polypeptide binding]; other site 391595010073 conserved gate region; other site 391595010074 putative PBP binding loops; other site 391595010075 ABC-ATPase subunit interface; other site 391595010076 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 391595010077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391595010078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595010079 dimer interface [polypeptide binding]; other site 391595010080 conserved gate region; other site 391595010081 putative PBP binding loops; other site 391595010082 ABC-ATPase subunit interface; other site 391595010083 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 391595010084 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391595010085 substrate binding pocket [chemical binding]; other site 391595010086 membrane-bound complex binding site; other site 391595010087 hinge residues; other site 391595010088 ATP12 chaperone protein; Region: ATP12; pfam07542 391595010089 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 391595010090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595010091 motif II; other site 391595010092 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 391595010093 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391595010094 RNA binding surface [nucleotide binding]; other site 391595010095 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 391595010096 active site 391595010097 camphor resistance protein CrcB; Provisional; Region: PRK14195 391595010098 recombination factor protein RarA; Reviewed; Region: PRK13342 391595010099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595010100 Walker A motif; other site 391595010101 ATP binding site [chemical binding]; other site 391595010102 Walker B motif; other site 391595010103 arginine finger; other site 391595010104 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 391595010105 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 391595010106 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 391595010107 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 391595010108 alphaNTD - beta interaction site [polypeptide binding]; other site 391595010109 alphaNTD homodimer interface [polypeptide binding]; other site 391595010110 alphaNTD - beta' interaction site [polypeptide binding]; other site 391595010111 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 391595010112 30S ribosomal protein S11; Validated; Region: PRK05309 391595010113 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 391595010114 30S ribosomal protein S13; Region: bact_S13; TIGR03631 391595010115 Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 1; Region: RGS-like_1; cd08734 391595010116 adenylate kinase; Reviewed; Region: adk; PRK00279 391595010117 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 391595010118 AMP-binding site [chemical binding]; other site 391595010119 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 391595010120 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 391595010121 SecY translocase; Region: SecY; pfam00344 391595010122 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 391595010123 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 391595010124 23S rRNA binding site [nucleotide binding]; other site 391595010125 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 391595010126 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 391595010127 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 391595010128 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 391595010129 5S rRNA interface [nucleotide binding]; other site 391595010130 23S rRNA interface [nucleotide binding]; other site 391595010131 L5 interface [polypeptide binding]; other site 391595010132 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 391595010133 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 391595010134 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 391595010135 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 391595010136 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 391595010137 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 391595010138 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 391595010139 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 391595010140 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 391595010141 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 391595010142 RNA binding site [nucleotide binding]; other site 391595010143 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 391595010144 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 391595010145 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 391595010146 23S rRNA interface [nucleotide binding]; other site 391595010147 putative translocon interaction site; other site 391595010148 signal recognition particle (SRP54) interaction site; other site 391595010149 L23 interface [polypeptide binding]; other site 391595010150 trigger factor interaction site; other site 391595010151 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 391595010152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595010153 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 391595010154 putative dimerization interface [polypeptide binding]; other site 391595010155 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595010156 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391595010157 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 391595010158 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 391595010159 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 391595010160 agmatinase; Region: agmatinase; TIGR01230 391595010161 Arginase family; Region: Arginase; cd09989 391595010162 active site 391595010163 Mn binding site [ion binding]; other site 391595010164 oligomer interface [polypeptide binding]; other site 391595010165 ornithine cyclodeaminase; Validated; Region: PRK07589 391595010166 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391595010167 conserved hypothetical protein; Region: TIGR02466 391595010168 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 391595010169 23S rRNA interface [nucleotide binding]; other site 391595010170 5S rRNA interface [nucleotide binding]; other site 391595010171 putative antibiotic binding site [chemical binding]; other site 391595010172 L25 interface [polypeptide binding]; other site 391595010173 L27 interface [polypeptide binding]; other site 391595010174 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 391595010175 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 391595010176 G-X-X-G motif; other site 391595010177 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 391595010178 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 391595010179 putative translocon binding site; other site 391595010180 protein-rRNA interface [nucleotide binding]; other site 391595010181 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 391595010182 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 391595010183 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 391595010184 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 391595010185 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 391595010186 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391595010187 DNA-binding site [nucleotide binding]; DNA binding site 391595010188 RNA-binding motif; other site 391595010189 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 391595010190 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 391595010191 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 391595010192 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 391595010193 intracellular protease, PfpI family; Region: PfpI; TIGR01382 391595010194 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 391595010195 conserved cys residue [active] 391595010196 elongation factor Tu; Reviewed; Region: PRK00049 391595010197 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 391595010198 G1 box; other site 391595010199 GEF interaction site [polypeptide binding]; other site 391595010200 GTP/Mg2+ binding site [chemical binding]; other site 391595010201 Switch I region; other site 391595010202 G2 box; other site 391595010203 G3 box; other site 391595010204 Switch II region; other site 391595010205 G4 box; other site 391595010206 G5 box; other site 391595010207 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 391595010208 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 391595010209 Antibiotic Binding Site [chemical binding]; other site 391595010210 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391595010211 Cytochrome P450; Region: p450; cl12078 391595010212 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 391595010213 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 391595010214 CAP-like domain; other site 391595010215 active site 391595010216 primary dimer interface [polypeptide binding]; other site 391595010217 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391595010218 Bacterial SH3 domain homologues; Region: SH3b; smart00287 391595010219 short chain dehydrogenase; Provisional; Region: PRK05993 391595010220 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 391595010221 NADP binding site [chemical binding]; other site 391595010222 active site 391595010223 steroid binding site; other site 391595010224 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 391595010225 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 391595010226 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 391595010227 Ligand binding site [chemical binding]; other site 391595010228 Electron transfer flavoprotein domain; Region: ETF; pfam01012 391595010229 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 391595010230 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 391595010231 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 391595010232 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 391595010233 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391595010234 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391595010235 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 391595010236 putative acyl-acceptor binding pocket; other site 391595010237 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 391595010238 dimerization domain swap beta strand [polypeptide binding]; other site 391595010239 regulatory protein interface [polypeptide binding]; other site 391595010240 active site 391595010241 regulatory phosphorylation site [posttranslational modification]; other site 391595010242 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 391595010243 active pocket/dimerization site; other site 391595010244 active site 391595010245 phosphorylation site [posttranslational modification] 391595010246 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 391595010247 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 391595010248 Hpr binding site; other site 391595010249 active site 391595010250 homohexamer subunit interaction site [polypeptide binding]; other site 391595010251 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 391595010252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391595010253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595010254 dimer interface [polypeptide binding]; other site 391595010255 phosphorylation site [posttranslational modification] 391595010256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595010257 ATP binding site [chemical binding]; other site 391595010258 Mg2+ binding site [ion binding]; other site 391595010259 G-X-G motif; other site 391595010260 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391595010261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595010262 active site 391595010263 phosphorylation site [posttranslational modification] 391595010264 intermolecular recognition site; other site 391595010265 dimerization interface [polypeptide binding]; other site 391595010266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391595010267 DNA binding site [nucleotide binding] 391595010268 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 391595010269 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 391595010270 active site 391595010271 substrate-binding site [chemical binding]; other site 391595010272 metal-binding site [ion binding] 391595010273 ATP binding site [chemical binding]; other site 391595010274 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595010275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595010276 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391595010277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595010278 non-specific DNA binding site [nucleotide binding]; other site 391595010279 salt bridge; other site 391595010280 sequence-specific DNA binding site [nucleotide binding]; other site 391595010281 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391595010282 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391595010283 active site 391595010284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595010285 META domain; Region: META; pfam03724 391595010286 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 391595010287 Recombination protein O N terminal; Region: RecO_N; pfam11967 391595010288 Recombination protein O C terminal; Region: RecO_C; pfam02565 391595010289 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 391595010290 GTPase Era; Reviewed; Region: era; PRK00089 391595010291 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 391595010292 G1 box; other site 391595010293 GTP/Mg2+ binding site [chemical binding]; other site 391595010294 Switch I region; other site 391595010295 G2 box; other site 391595010296 Switch II region; other site 391595010297 G3 box; other site 391595010298 G4 box; other site 391595010299 G5 box; other site 391595010300 KH domain; Region: KH_2; pfam07650 391595010301 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 391595010302 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 391595010303 dimerization interface [polypeptide binding]; other site 391595010304 active site 391595010305 metal binding site [ion binding]; metal-binding site 391595010306 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 391595010307 dsRNA binding site [nucleotide binding]; other site 391595010308 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 391595010309 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 391595010310 Catalytic site [active] 391595010311 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 391595010312 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 391595010313 LysE type translocator; Region: LysE; cl00565 391595010314 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 391595010315 active site 391595010316 hydrophilic channel; other site 391595010317 dimerization interface [polypeptide binding]; other site 391595010318 catalytic residues [active] 391595010319 active site lid [active] 391595010320 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 391595010321 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 391595010322 HD domain; Region: HD_4; pfam13328 391595010323 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 391595010324 synthetase active site [active] 391595010325 NTP binding site [chemical binding]; other site 391595010326 metal binding site [ion binding]; metal-binding site 391595010327 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 391595010328 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 391595010329 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 391595010330 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 391595010331 catalytic center binding site [active] 391595010332 ATP binding site [chemical binding]; other site 391595010333 Uncharacterized conserved protein [Function unknown]; Region: COG1432 391595010334 LabA_like proteins; Region: LabA; cd10911 391595010335 putative metal binding site [ion binding]; other site 391595010336 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 391595010337 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 391595010338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391595010339 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 391595010340 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391595010341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595010342 S-adenosylmethionine binding site [chemical binding]; other site 391595010343 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 391595010344 RNA/DNA hybrid binding site [nucleotide binding]; other site 391595010345 active site 391595010346 Predicted membrane protein [Function unknown]; Region: COG2860 391595010347 UPF0126 domain; Region: UPF0126; pfam03458 391595010348 UPF0126 domain; Region: UPF0126; pfam03458 391595010349 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 391595010350 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 391595010351 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 391595010352 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391595010353 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 391595010354 active site 391595010355 catalytic triad [active] 391595010356 oxyanion hole [active] 391595010357 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595010358 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391595010359 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391595010360 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595010361 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 391595010362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595010363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595010364 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391595010365 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391595010366 HlyD family secretion protein; Region: HlyD_3; pfam13437 391595010367 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391595010368 Protein export membrane protein; Region: SecD_SecF; cl14618 391595010369 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 391595010370 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 391595010371 putative active site [active] 391595010372 substrate binding site [chemical binding]; other site 391595010373 putative cosubstrate binding site; other site 391595010374 catalytic site [active] 391595010375 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 391595010376 substrate binding site [chemical binding]; other site 391595010377 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391595010378 active site 391595010379 catalytic residues [active] 391595010380 metal binding site [ion binding]; metal-binding site 391595010381 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391595010382 active site 391595010383 catalytic residues [active] 391595010384 metal binding site [ion binding]; metal-binding site 391595010385 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 391595010386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391595010387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595010388 homodimer interface [polypeptide binding]; other site 391595010389 catalytic residue [active] 391595010390 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 391595010391 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 391595010392 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 391595010393 putative dimer interface [polypeptide binding]; other site 391595010394 N-terminal domain interface [polypeptide binding]; other site 391595010395 putative substrate binding pocket (H-site) [chemical binding]; other site 391595010396 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391595010397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595010398 active site 391595010399 phosphorylation site [posttranslational modification] 391595010400 intermolecular recognition site; other site 391595010401 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391595010402 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 391595010403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595010404 catalytic residue [active] 391595010405 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 391595010406 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391595010407 murein hydrolase B; Provisional; Region: PRK10760; cl17906 391595010408 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391595010409 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 391595010410 AAA domain; Region: AAA_23; pfam13476 391595010411 Walker A/P-loop; other site 391595010412 ATP binding site [chemical binding]; other site 391595010413 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 391595010414 Walker B; other site 391595010415 D-loop; other site 391595010416 H-loop/switch region; other site 391595010417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595010418 DNA-binding site [nucleotide binding]; DNA binding site 391595010419 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 391595010420 F0F1 ATP synthase subunit B; Provisional; Region: PRK13455 391595010421 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 391595010422 F0F1 ATP synthase subunit B'; Provisional; Region: PRK13454 391595010423 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 391595010424 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 391595010425 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 391595010426 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 391595010427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595010428 dimerization interface [polypeptide binding]; other site 391595010429 putative DNA binding site [nucleotide binding]; other site 391595010430 putative Zn2+ binding site [ion binding]; other site 391595010431 EamA-like transporter family; Region: EamA; pfam00892 391595010432 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391595010433 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595010434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595010435 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595010436 dimerization interface [polypeptide binding]; other site 391595010437 signal recognition particle protein; Provisional; Region: PRK10867 391595010438 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 391595010439 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 391595010440 P loop; other site 391595010441 GTP binding site [chemical binding]; other site 391595010442 Signal peptide binding domain; Region: SRP_SPB; pfam02978 391595010443 NIPSNAP; Region: NIPSNAP; pfam07978 391595010444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391595010445 chorismate mutase; Provisional; Region: PRK09239 391595010446 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 391595010447 RimM N-terminal domain; Region: RimM; pfam01782 391595010448 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 391595010449 PRC-barrel domain; Region: PRC; pfam05239 391595010450 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 391595010451 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 391595010452 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 391595010453 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 391595010454 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 391595010455 active site 391595010456 ATPase MipZ; Region: MipZ; pfam09140 391595010457 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391595010458 P-loop; other site 391595010459 Magnesium ion binding site [ion binding]; other site 391595010460 EamA-like transporter family; Region: EamA; pfam00892 391595010461 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391595010462 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 391595010463 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 391595010464 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391595010465 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391595010466 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 391595010467 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595010468 Amidohydrolase; Region: Amidohydro_4; pfam13147 391595010469 active site 391595010470 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391595010471 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391595010472 Domain of unknown function (DUF309); Region: DUF309; pfam03745 391595010473 DctM-like transporters; Region: DctM; pfam06808 391595010474 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391595010475 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391595010476 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595010477 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 391595010478 substrate binding site [chemical binding]; other site 391595010479 active site 391595010480 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 391595010481 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 391595010482 domain interfaces; other site 391595010483 active site 391595010484 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 391595010485 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 391595010486 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 391595010487 classical (c) SDRs; Region: SDR_c; cd05233 391595010488 NAD(P) binding site [chemical binding]; other site 391595010489 active site 391595010490 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 391595010491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595010492 S-adenosylmethionine binding site [chemical binding]; other site 391595010493 Uncharacterized conserved protein [Function unknown]; Region: COG2127 391595010494 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 391595010495 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 391595010496 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 391595010497 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391595010498 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391595010499 metal-binding site [ion binding] 391595010500 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391595010501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595010502 motif II; other site 391595010503 FixH; Region: FixH; pfam05751 391595010504 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 391595010505 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 391595010506 4Fe-4S binding domain; Region: Fer4_5; pfam12801 391595010507 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391595010508 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 391595010509 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 391595010510 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 391595010511 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 391595010512 Cytochrome c; Region: Cytochrom_C; pfam00034 391595010513 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 391595010514 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 391595010515 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 391595010516 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 391595010517 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 391595010518 Low-spin heme binding site [chemical binding]; other site 391595010519 Putative water exit pathway; other site 391595010520 Binuclear center (active site) [active] 391595010521 Putative proton exit pathway; other site 391595010522 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391595010523 Ligand Binding Site [chemical binding]; other site 391595010524 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595010525 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391595010526 ligand binding site [chemical binding]; other site 391595010527 flexible hinge region; other site 391595010528 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391595010529 putative switch regulator; other site 391595010530 non-specific DNA interactions [nucleotide binding]; other site 391595010531 DNA binding site [nucleotide binding] 391595010532 sequence specific DNA binding site [nucleotide binding]; other site 391595010533 putative cAMP binding site [chemical binding]; other site 391595010534 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 391595010535 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595010536 FeS/SAM binding site; other site 391595010537 HemN C-terminal domain; Region: HemN_C; pfam06969 391595010538 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 391595010539 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595010540 Walker A/P-loop; other site 391595010541 ATP binding site [chemical binding]; other site 391595010542 Q-loop/lid; other site 391595010543 ABC transporter signature motif; other site 391595010544 Walker B; other site 391595010545 D-loop; other site 391595010546 H-loop/switch region; other site 391595010547 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 391595010548 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595010549 Walker A/P-loop; other site 391595010550 ATP binding site [chemical binding]; other site 391595010551 Q-loop/lid; other site 391595010552 ABC transporter signature motif; other site 391595010553 Walker B; other site 391595010554 D-loop; other site 391595010555 H-loop/switch region; other site 391595010556 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391595010557 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 391595010558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595010559 dimer interface [polypeptide binding]; other site 391595010560 conserved gate region; other site 391595010561 putative PBP binding loops; other site 391595010562 ABC-ATPase subunit interface; other site 391595010563 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 391595010564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595010565 dimer interface [polypeptide binding]; other site 391595010566 conserved gate region; other site 391595010567 putative PBP binding loops; other site 391595010568 ABC-ATPase subunit interface; other site 391595010569 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 391595010570 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 391595010571 Cytochrome c2 [Energy production and conversion]; Region: COG3474 391595010572 prephenate dehydratase; Provisional; Region: PRK11899 391595010573 Prephenate dehydratase; Region: PDT; pfam00800 391595010574 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 391595010575 putative L-Phe binding site [chemical binding]; other site 391595010576 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 391595010577 hydrophobic ligand binding site; other site 391595010578 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 391595010579 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 391595010580 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 391595010581 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 391595010582 putative NADH binding site [chemical binding]; other site 391595010583 putative active site [active] 391595010584 nudix motif; other site 391595010585 putative metal binding site [ion binding]; other site 391595010586 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 391595010587 active site 391595010588 metal binding site [ion binding]; metal-binding site 391595010589 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391595010590 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 391595010591 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 391595010592 excinuclease ABC subunit B; Provisional; Region: PRK05298 391595010593 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391595010594 ATP binding site [chemical binding]; other site 391595010595 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391595010596 nucleotide binding region [chemical binding]; other site 391595010597 ATP-binding site [chemical binding]; other site 391595010598 Ultra-violet resistance protein B; Region: UvrB; pfam12344 391595010599 UvrB/uvrC motif; Region: UVR; pfam02151 391595010600 Abortive infection C-terminus; Region: Abi_C; pfam14355 391595010601 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 391595010602 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 391595010603 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 391595010604 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 391595010605 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391595010606 active site 391595010607 nucleotide binding site [chemical binding]; other site 391595010608 HIGH motif; other site 391595010609 KMSKS motif; other site 391595010610 tellurite resistance protein terB; Region: terB; cd07176 391595010611 putative metal binding site [ion binding]; other site 391595010612 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 391595010613 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 391595010614 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 391595010615 active site 391595010616 (T/H)XGH motif; other site 391595010617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 391595010618 MOSC domain; Region: MOSC; pfam03473 391595010619 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 391595010620 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 391595010621 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391595010622 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391595010623 ABC transporter; Region: ABC_tran_2; pfam12848 391595010624 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391595010625 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 391595010626 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 391595010627 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 391595010628 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391595010629 DNA-binding site [nucleotide binding]; DNA binding site 391595010630 RNA-binding motif; other site 391595010631 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391595010632 DNA-binding site [nucleotide binding]; DNA binding site 391595010633 RNA-binding motif; other site 391595010634 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 391595010635 active site 391595010636 catalytic triad [active] 391595010637 oxyanion hole [active] 391595010638 switch loop; other site 391595010639 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 391595010640 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391595010641 Walker A/P-loop; other site 391595010642 ATP binding site [chemical binding]; other site 391595010643 Q-loop/lid; other site 391595010644 ABC transporter signature motif; other site 391595010645 Walker B; other site 391595010646 D-loop; other site 391595010647 H-loop/switch region; other site 391595010648 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 391595010649 glycine dehydrogenase; Provisional; Region: PRK05367 391595010650 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 391595010651 tetramer interface [polypeptide binding]; other site 391595010652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595010653 catalytic residue [active] 391595010654 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 391595010655 tetramer interface [polypeptide binding]; other site 391595010656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595010657 catalytic residue [active] 391595010658 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 391595010659 lipoyl attachment site [posttranslational modification]; other site 391595010660 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 391595010661 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595010662 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 391595010663 putative active site pocket [active] 391595010664 dimerization interface [polypeptide binding]; other site 391595010665 putative catalytic residue [active] 391595010666 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 391595010667 putative efflux protein, MATE family; Region: matE; TIGR00797 391595010668 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 391595010669 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391595010670 active site 391595010671 HIGH motif; other site 391595010672 nucleotide binding site [chemical binding]; other site 391595010673 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 391595010674 active site 391595010675 KMSKS motif; other site 391595010676 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391595010677 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391595010678 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 391595010679 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391595010680 NAD synthetase; Provisional; Region: PRK13981 391595010681 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 391595010682 multimer interface [polypeptide binding]; other site 391595010683 active site 391595010684 catalytic triad [active] 391595010685 protein interface 1 [polypeptide binding]; other site 391595010686 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 391595010687 homodimer interface [polypeptide binding]; other site 391595010688 NAD binding pocket [chemical binding]; other site 391595010689 ATP binding pocket [chemical binding]; other site 391595010690 Mg binding site [ion binding]; other site 391595010691 active-site loop [active] 391595010692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391595010693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391595010694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391595010695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391595010696 MORN repeat; Region: MORN; cl14787 391595010697 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 391595010698 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 391595010699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595010700 NAD(P) binding site [chemical binding]; other site 391595010701 active site 391595010702 2-isopropylmalate synthase; Validated; Region: PRK00915 391595010703 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 391595010704 active site 391595010705 catalytic residues [active] 391595010706 metal binding site [ion binding]; metal-binding site 391595010707 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 391595010708 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391595010709 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391595010710 substrate binding pocket [chemical binding]; other site 391595010711 membrane-bound complex binding site; other site 391595010712 hinge residues; other site 391595010713 rod shape-determining protein MreB; Provisional; Region: PRK13927 391595010714 MreB and similar proteins; Region: MreB_like; cd10225 391595010715 nucleotide binding site [chemical binding]; other site 391595010716 Mg binding site [ion binding]; other site 391595010717 putative protofilament interaction site [polypeptide binding]; other site 391595010718 RodZ interaction site [polypeptide binding]; other site 391595010719 rod shape-determining protein MreC; Provisional; Region: PRK13922 391595010720 rod shape-determining protein MreC; Region: MreC; pfam04085 391595010721 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 391595010722 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 391595010723 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 391595010724 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 391595010725 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 391595010726 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 391595010727 putative ligand binding site [chemical binding]; other site 391595010728 NAD binding site [chemical binding]; other site 391595010729 dimerization interface [polypeptide binding]; other site 391595010730 catalytic site [active] 391595010731 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 391595010732 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 391595010733 active site 391595010734 Zn binding site [ion binding]; other site 391595010735 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 391595010736 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 391595010737 ATP binding site [chemical binding]; other site 391595010738 substrate interface [chemical binding]; other site 391595010739 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 391595010740 trimer interface [polypeptide binding]; other site 391595010741 active site 391595010742 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 391595010743 Flavoprotein; Region: Flavoprotein; pfam02441 391595010744 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 391595010745 Protein of unknown function, DUF399; Region: DUF399; pfam04187 391595010746 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 391595010747 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391595010748 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391595010749 DNA binding residues [nucleotide binding] 391595010750 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 391595010751 homotrimer interface [polypeptide binding]; other site 391595010752 Walker A motif; other site 391595010753 GTP binding site [chemical binding]; other site 391595010754 Walker B motif; other site 391595010755 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391595010756 catalytic core [active] 391595010757 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 391595010758 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391595010759 putative C-terminal domain interface [polypeptide binding]; other site 391595010760 putative GSH binding site (G-site) [chemical binding]; other site 391595010761 putative dimer interface [polypeptide binding]; other site 391595010762 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 391595010763 putative N-terminal domain interface [polypeptide binding]; other site 391595010764 putative dimer interface [polypeptide binding]; other site 391595010765 putative substrate binding pocket (H-site) [chemical binding]; other site 391595010766 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 391595010767 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 391595010768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595010769 Walker A motif; other site 391595010770 ATP binding site [chemical binding]; other site 391595010771 Walker B motif; other site 391595010772 arginine finger; other site 391595010773 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 391595010774 glutathione synthetase; Provisional; Region: PRK05246 391595010775 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 391595010776 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 391595010777 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 391595010778 Predicted methyltransferases [General function prediction only]; Region: COG0313 391595010779 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 391595010780 putative SAM binding site [chemical binding]; other site 391595010781 putative homodimer interface [polypeptide binding]; other site 391595010782 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391595010783 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 391595010784 putative ligand binding site [chemical binding]; other site 391595010785 PII uridylyl-transferase; Provisional; Region: PRK05092 391595010786 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391595010787 metal binding triad; other site 391595010788 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391595010789 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 391595010790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391595010791 Zn2+ binding site [ion binding]; other site 391595010792 Mg2+ binding site [ion binding]; other site 391595010793 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 391595010794 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 391595010795 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 391595010796 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 391595010797 Rhomboid family; Region: Rhomboid; pfam01694 391595010798 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 391595010799 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 391595010800 active site 391595010801 HIGH motif; other site 391595010802 dimer interface [polypeptide binding]; other site 391595010803 KMSKS motif; other site 391595010804 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 391595010805 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 391595010806 active site 391595010807 Zn binding site [ion binding]; other site 391595010808 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 391595010809 putative FMN binding site [chemical binding]; other site 391595010810 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 391595010811 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 391595010812 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391595010813 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 391595010814 dimer interface [polypeptide binding]; other site 391595010815 substrate binding site [chemical binding]; other site 391595010816 metal binding site [ion binding]; metal-binding site 391595010817 Response regulator receiver domain; Region: Response_reg; pfam00072 391595010818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595010819 active site 391595010820 phosphorylation site [posttranslational modification] 391595010821 intermolecular recognition site; other site 391595010822 dimerization interface [polypeptide binding]; other site 391595010823 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391595010824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391595010825 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 391595010826 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 391595010827 dimer interface [polypeptide binding]; other site 391595010828 anticodon binding site; other site 391595010829 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391595010830 motif 1; other site 391595010831 dimer interface [polypeptide binding]; other site 391595010832 active site 391595010833 motif 2; other site 391595010834 GAD domain; Region: GAD; pfam02938 391595010835 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391595010836 active site 391595010837 motif 3; other site 391595010838 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391595010839 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 391595010840 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 391595010841 [2Fe-2S] cluster binding site [ion binding]; other site 391595010842 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595010843 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595010844 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595010845 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595010846 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 391595010847 substrate binding pocket [chemical binding]; other site 391595010848 dimerization interface [polypeptide binding]; other site 391595010849 HAMP domain; Region: HAMP; pfam00672 391595010850 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391595010851 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391595010852 dimer interface [polypeptide binding]; other site 391595010853 putative CheW interface [polypeptide binding]; other site 391595010854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391595010855 Transposase; Region: HTH_Tnp_1; cl17663 391595010856 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 391595010857 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 391595010858 oligomeric interface; other site 391595010859 putative active site [active] 391595010860 homodimer interface [polypeptide binding]; other site 391595010861 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391595010862 Autoinducer synthetase; Region: Autoind_synth; cl17404 391595010863 Autoinducer binding domain; Region: Autoind_bind; pfam03472 391595010864 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391595010865 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 391595010866 catalytic residues [active] 391595010867 catalytic nucleophile [active] 391595010868 Recombinase; Region: Recombinase; pfam07508 391595010869 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 391595010870 Recombinase; Region: Recombinase; pfam07508 391595010871 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391595010872 metal binding site [ion binding]; metal-binding site 391595010873 active site 391595010874 I-site; other site 391595010875 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391595010876 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 391595010877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391595010878 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391595010879 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391595010880 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391595010881 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 391595010882 catalytic residues [active] 391595010883 catalytic nucleophile [active] 391595010884 Recombinase; Region: Recombinase; pfam07508 391595010885 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 391595010886 Recombinase; Region: Recombinase; pfam07508 391595010887 Helix-turn-helix domain; Region: HTH_28; pfam13518 391595010888 Transposase; Region: HTH_Tnp_1; pfam01527 391595010889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391595010890 Right handed beta helix region; Region: Beta_helix; pfam13229 391595010891 Right handed beta helix region; Region: Beta_helix; pfam13229 391595010892 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391595010893 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391595010894 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 391595010895 catalytic residues [active] 391595010896 catalytic nucleophile [active] 391595010897 Recombinase; Region: Recombinase; pfam07508 391595010898 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 391595010899 Recombinase; Region: Recombinase; pfam07508 391595010900 putative transposase OrfB; Reviewed; Region: PHA02517 391595010901 HTH-like domain; Region: HTH_21; pfam13276 391595010902 Integrase core domain; Region: rve; pfam00665 391595010903 Integrase core domain; Region: rve_3; pfam13683 391595010904 Transposase; Region: HTH_Tnp_1; pfam01527 391595010905 Autoinducer binding domain; Region: Autoind_bind; pfam03472 391595010906 Transposase; Region: HTH_Tnp_1; cl17663 391595010907 putative transposase OrfB; Reviewed; Region: PHA02517 391595010908 HTH-like domain; Region: HTH_21; pfam13276 391595010909 Integrase core domain; Region: rve; pfam00665 391595010910 Integrase core domain; Region: rve_3; pfam13683 391595010911 Autoinducer synthetase; Region: Autoind_synth; cl17404 391595010912 Helix-turn-helix domain; Region: HTH_38; pfam13936 391595010913 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 391595010914 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 391595010915 Int/Topo IB signature motif; other site 391595010916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391595010917 Transposase; Region: HTH_Tnp_1; cl17663 391595010918 Integrase core domain; Region: rve; pfam00665 391595010919 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391595010920 HSP70 interaction site [polypeptide binding]; other site 391595010921 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 391595010922 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 391595010923 dimer interface [polypeptide binding]; other site 391595010924 active site 391595010925 glycine-pyridoxal phosphate binding site [chemical binding]; other site 391595010926 folate binding site [chemical binding]; other site 391595010927 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391595010928 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 391595010929 dimerization interface [polypeptide binding]; other site 391595010930 ligand binding site [chemical binding]; other site 391595010931 NADP binding site [chemical binding]; other site 391595010932 catalytic site [active] 391595010933 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 391595010934 CoA binding domain; Region: CoA_binding; smart00881 391595010935 CoA-ligase; Region: Ligase_CoA; pfam00549 391595010936 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 391595010937 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 391595010938 CoA-ligase; Region: Ligase_CoA; pfam00549 391595010939 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 391595010940 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595010941 catalytic residue [active] 391595010942 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391595010943 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391595010944 DNA binding residues [nucleotide binding] 391595010945 dimerization interface [polypeptide binding]; other site 391595010946 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 391595010947 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 391595010948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595010949 Walker A/P-loop; other site 391595010950 ATP binding site [chemical binding]; other site 391595010951 Q-loop/lid; other site 391595010952 ABC transporter signature motif; other site 391595010953 Walker B; other site 391595010954 D-loop; other site 391595010955 H-loop/switch region; other site 391595010956 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391595010957 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391595010958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391595010959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391595010960 dimerization interface [polypeptide binding]; other site 391595010961 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 391595010962 linker region; other site 391595010963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595010964 dimer interface [polypeptide binding]; other site 391595010965 phosphorylation site [posttranslational modification] 391595010966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595010967 ATP binding site [chemical binding]; other site 391595010968 Mg2+ binding site [ion binding]; other site 391595010969 G-X-G motif; other site 391595010970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391595010971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595010972 active site 391595010973 phosphorylation site [posttranslational modification] 391595010974 intermolecular recognition site; other site 391595010975 dimerization interface [polypeptide binding]; other site 391595010976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391595010977 DNA binding site [nucleotide binding] 391595010978 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 391595010979 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 391595010980 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 391595010981 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 391595010982 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 391595010983 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 391595010984 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595010985 FeS/SAM binding site; other site 391595010986 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 391595010987 D-glutamate deacylase; Validated; Region: PRK09061 391595010988 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595010989 active site 391595010990 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595010991 D-glutamate deacylase; Validated; Region: PRK09061 391595010992 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595010993 active site 391595010994 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595010995 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 391595010996 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391595010997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595010998 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 391595010999 C1q domain; Region: C1q; cl17543 391595011000 Sulfolobus plasmid regulatory protein; Region: Sulfolobus_pRN; pfam05584 391595011001 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 391595011002 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 391595011003 active site 391595011004 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 391595011005 Isochorismatase family; Region: Isochorismatase; pfam00857 391595011006 catalytic triad [active] 391595011007 metal binding site [ion binding]; metal-binding site 391595011008 conserved cis-peptide bond; other site 391595011009 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 391595011010 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 391595011011 active site residue [active] 391595011012 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 391595011013 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 391595011014 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 391595011015 ligand binding site [chemical binding]; other site 391595011016 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 391595011017 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391595011018 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 391595011019 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391595011020 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 391595011021 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391595011022 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 391595011023 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 391595011024 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 391595011025 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 391595011026 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391595011027 PAS domain; Region: PAS_9; pfam13426 391595011028 putative active site [active] 391595011029 heme pocket [chemical binding]; other site 391595011030 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391595011031 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391595011032 metal binding site [ion binding]; metal-binding site 391595011033 active site 391595011034 I-site; other site 391595011035 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391595011036 Protein of unknown function DUF16; Region: DUF16; pfam01519 391595011037 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 391595011038 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391595011039 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391595011040 substrate binding pocket [chemical binding]; other site 391595011041 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391595011042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595011043 S-adenosylmethionine binding site [chemical binding]; other site 391595011044 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 391595011045 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 391595011046 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 391595011047 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 391595011048 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 391595011049 Phage protein D [General function prediction only]; Region: COG3500 391595011050 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 391595011051 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 391595011052 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 391595011053 virulence protein SpvB; Provisional; Region: PRK15244 391595011054 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 391595011055 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 391595011056 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 391595011057 Walker A motif; other site 391595011058 ATP binding site [chemical binding]; other site 391595011059 Walker B motif; other site 391595011060 arginine finger; other site 391595011061 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 391595011062 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391595011063 intersubunit interface [polypeptide binding]; other site 391595011064 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 391595011065 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 391595011066 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391595011067 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391595011068 ABC-ATPase subunit interface; other site 391595011069 dimer interface [polypeptide binding]; other site 391595011070 putative PBP binding regions; other site 391595011071 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391595011072 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391595011073 ABC-ATPase subunit interface; other site 391595011074 dimer interface [polypeptide binding]; other site 391595011075 putative PBP binding regions; other site 391595011076 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391595011077 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391595011078 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 391595011079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391595011080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595011081 dimer interface [polypeptide binding]; other site 391595011082 conserved gate region; other site 391595011083 putative PBP binding loops; other site 391595011084 ABC-ATPase subunit interface; other site 391595011085 Hemin uptake protein hemP; Region: hemP; pfam10636 391595011086 Imelysin; Region: Peptidase_M75; cl09159 391595011087 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 391595011088 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 391595011089 dimerization interface [polypeptide binding]; other site 391595011090 DPS ferroxidase diiron center [ion binding]; other site 391595011091 ion pore; other site 391595011092 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 391595011093 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 391595011094 Imelysin; Region: Peptidase_M75; pfam09375 391595011095 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 391595011096 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391595011097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595011098 Walker A/P-loop; other site 391595011099 ATP binding site [chemical binding]; other site 391595011100 Q-loop/lid; other site 391595011101 ABC transporter signature motif; other site 391595011102 Walker B; other site 391595011103 D-loop; other site 391595011104 H-loop/switch region; other site 391595011105 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391595011106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595011107 dimer interface [polypeptide binding]; other site 391595011108 conserved gate region; other site 391595011109 putative PBP binding loops; other site 391595011110 ABC-ATPase subunit interface; other site 391595011111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 391595011112 NMT1/THI5 like; Region: NMT1; pfam09084 391595011113 substrate binding pocket [chemical binding]; other site 391595011114 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 391595011115 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 391595011116 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 391595011117 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 391595011118 ligand binding site [chemical binding]; other site 391595011119 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 391595011120 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 391595011121 putative hydrophobic ligand binding site [chemical binding]; other site 391595011122 protein interface [polypeptide binding]; other site 391595011123 gate; other site 391595011124 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 391595011125 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 391595011126 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 391595011127 Predicted secreted protein [Function unknown]; Region: COG5501 391595011128 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 391595011129 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 391595011130 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391595011131 active site residue [active] 391595011132 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 391595011133 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391595011134 substrate binding pocket [chemical binding]; other site 391595011135 membrane-bound complex binding site; other site 391595011136 hinge residues; other site 391595011137 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 391595011138 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 391595011139 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 391595011140 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 391595011141 Trp docking motif [polypeptide binding]; other site 391595011142 dimer interface [polypeptide binding]; other site 391595011143 active site 391595011144 small subunit binding site [polypeptide binding]; other site 391595011145 Cytochrome c2 [Energy production and conversion]; Region: COG3474 391595011146 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 391595011147 S-formylglutathione hydrolase; Region: PLN02442 391595011148 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 391595011149 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 391595011150 substrate binding site [chemical binding]; other site 391595011151 catalytic Zn binding site [ion binding]; other site 391595011152 NAD binding site [chemical binding]; other site 391595011153 structural Zn binding site [ion binding]; other site 391595011154 dimer interface [polypeptide binding]; other site 391595011155 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391595011156 Predicted secreted protein [Function unknown]; Region: COG5501 391595011157 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 391595011158 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 391595011159 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 391595011160 PAS fold; Region: PAS_7; pfam12860 391595011161 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391595011162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595011163 dimer interface [polypeptide binding]; other site 391595011164 phosphorylation site [posttranslational modification] 391595011165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595011166 ATP binding site [chemical binding]; other site 391595011167 Mg2+ binding site [ion binding]; other site 391595011168 G-X-G motif; other site 391595011169 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391595011170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595011171 active site 391595011172 phosphorylation site [posttranslational modification] 391595011173 intermolecular recognition site; other site 391595011174 dimerization interface [polypeptide binding]; other site 391595011175 FIST N domain; Region: FIST; pfam08495 391595011176 Uncharacterized conserved protein [Function unknown]; Region: COG3287 391595011177 FIST C domain; Region: FIST_C; pfam10442 391595011178 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391595011179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595011180 active site 391595011181 phosphorylation site [posttranslational modification] 391595011182 intermolecular recognition site; other site 391595011183 dimerization interface [polypeptide binding]; other site 391595011184 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391595011185 DNA binding residues [nucleotide binding] 391595011186 dimerization interface [polypeptide binding]; other site 391595011187 Oxygen tolerance; Region: BatD; pfam13584 391595011188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595011189 TPR motif; other site 391595011190 binding surface 391595011191 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 391595011192 metal ion-dependent adhesion site (MIDAS); other site 391595011193 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391595011194 metal ion-dependent adhesion site (MIDAS); other site 391595011195 Protein of unknown function DUF58; Region: DUF58; pfam01882 391595011196 MoxR-like ATPases [General function prediction only]; Region: COG0714 391595011197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595011198 Walker A motif; other site 391595011199 ATP binding site [chemical binding]; other site 391595011200 Walker B motif; other site 391595011201 arginine finger; other site 391595011202 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391595011203 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391595011204 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 391595011205 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391595011206 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595011207 TM-ABC transporter signature motif; other site 391595011208 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391595011209 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595011210 TM-ABC transporter signature motif; other site 391595011211 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391595011212 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391595011213 Walker A/P-loop; other site 391595011214 ATP binding site [chemical binding]; other site 391595011215 Q-loop/lid; other site 391595011216 ABC transporter signature motif; other site 391595011217 Walker B; other site 391595011218 D-loop; other site 391595011219 H-loop/switch region; other site 391595011220 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391595011221 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 391595011222 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391595011223 putative ligand binding site [chemical binding]; other site 391595011224 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 391595011225 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595011226 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 391595011227 active site 391595011228 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 391595011229 putative heme binding pocket [chemical binding]; other site 391595011230 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 391595011231 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 391595011232 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595011233 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391595011234 active site 391595011235 UDP-glucose 4-epimerase; Region: PLN02240 391595011236 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 391595011237 NAD binding site [chemical binding]; other site 391595011238 homodimer interface [polypeptide binding]; other site 391595011239 active site 391595011240 substrate binding site [chemical binding]; other site 391595011241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391595011242 Transposase; Region: HTH_Tnp_1; cl17663 391595011243 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 391595011244 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391595011245 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391595011246 putative catalytic site [active] 391595011247 putative phosphate binding site [ion binding]; other site 391595011248 putative metal binding site [ion binding]; other site 391595011249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595011250 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 391595011251 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 391595011252 putative acyl-acceptor binding pocket; other site 391595011253 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 391595011254 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 391595011255 NIPSNAP; Region: NIPSNAP; pfam07978 391595011256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391595011257 dimerization interface [polypeptide binding]; other site 391595011258 putative DNA binding site [nucleotide binding]; other site 391595011259 putative Zn2+ binding site [ion binding]; other site 391595011260 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 391595011261 TMAO/DMSO reductase; Reviewed; Region: PRK05363 391595011262 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 391595011263 Moco binding site; other site 391595011264 metal coordination site [ion binding]; other site 391595011265 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 391595011266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595011267 motif II; other site 391595011268 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 391595011269 Fasciclin domain; Region: Fasciclin; pfam02469 391595011270 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 391595011271 Clp amino terminal domain; Region: Clp_N; pfam02861 391595011272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595011273 Walker A motif; other site 391595011274 ATP binding site [chemical binding]; other site 391595011275 Walker B motif; other site 391595011276 arginine finger; other site 391595011277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595011278 Walker A motif; other site 391595011279 ATP binding site [chemical binding]; other site 391595011280 Walker B motif; other site 391595011281 arginine finger; other site 391595011282 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391595011283 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 391595011284 active site 391595011285 dimer interface [polypeptide binding]; other site 391595011286 DNA polymerase IV; Provisional; Region: PRK02794 391595011287 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 391595011288 active site 391595011289 DNA binding site [nucleotide binding] 391595011290 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 391595011291 putative S-transferase; Provisional; Region: PRK11752 391595011292 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 391595011293 C-terminal domain interface [polypeptide binding]; other site 391595011294 GSH binding site (G-site) [chemical binding]; other site 391595011295 dimer interface [polypeptide binding]; other site 391595011296 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 391595011297 dimer interface [polypeptide binding]; other site 391595011298 N-terminal domain interface [polypeptide binding]; other site 391595011299 active site 391595011300 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391595011301 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391595011302 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 391595011303 acyl-activating enzyme (AAE) consensus motif; other site 391595011304 active site 391595011305 AMP binding site [chemical binding]; other site 391595011306 CoA binding site [chemical binding]; other site 391595011307 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391595011308 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391595011309 Walker A/P-loop; other site 391595011310 ATP binding site [chemical binding]; other site 391595011311 Q-loop/lid; other site 391595011312 ABC transporter signature motif; other site 391595011313 Walker B; other site 391595011314 D-loop; other site 391595011315 H-loop/switch region; other site 391595011316 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 391595011317 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391595011318 putative ligand binding site [chemical binding]; other site 391595011319 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391595011320 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391595011321 TM-ABC transporter signature motif; other site 391595011322 Short C-terminal domain; Region: SHOCT; pfam09851 391595011323 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391595011324 TM-ABC transporter signature motif; other site 391595011325 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391595011326 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391595011327 Walker A/P-loop; other site 391595011328 ATP binding site [chemical binding]; other site 391595011329 Q-loop/lid; other site 391595011330 ABC transporter signature motif; other site 391595011331 Walker B; other site 391595011332 D-loop; other site 391595011333 H-loop/switch region; other site 391595011334 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 391595011335 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391595011336 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 391595011337 acyl-activating enzyme (AAE) consensus motif; other site 391595011338 putative AMP binding site [chemical binding]; other site 391595011339 putative active site [active] 391595011340 putative CoA binding site [chemical binding]; other site 391595011341 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 391595011342 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391595011343 catalytic loop [active] 391595011344 iron binding site [ion binding]; other site 391595011345 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 391595011346 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391595011347 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 391595011348 [4Fe-4S] binding site [ion binding]; other site 391595011349 molybdopterin cofactor binding site; other site 391595011350 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 391595011351 molybdopterin cofactor binding site; other site 391595011352 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391595011353 catalytic core [active] 391595011354 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391595011355 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 391595011356 C-terminal domain interface [polypeptide binding]; other site 391595011357 GSH binding site (G-site) [chemical binding]; other site 391595011358 dimer interface [polypeptide binding]; other site 391595011359 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 391595011360 dimer interface [polypeptide binding]; other site 391595011361 substrate binding pocket (H-site) [chemical binding]; other site 391595011362 N-terminal domain interface [polypeptide binding]; other site 391595011363 Saccharopine Dehydrogenase NAD-binding and catalytic domains; Region: SDH; cd12188 391595011364 active site 391595011365 ligand binding site [chemical binding]; other site 391595011366 homodimer interface [polypeptide binding]; other site 391595011367 NAD(P) binding site [chemical binding]; other site 391595011368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595011369 NAD(P) binding site [chemical binding]; other site 391595011370 active site 391595011371 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 391595011372 MFS/sugar transport protein; Region: MFS_2; pfam13347 391595011373 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 391595011374 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 391595011375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391595011376 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 391595011377 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391595011378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391595011379 DNA binding residues [nucleotide binding] 391595011380 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 391595011381 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 391595011382 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391595011383 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391595011384 active site pocket [active] 391595011385 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 391595011386 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391595011387 putative ligand binding site [chemical binding]; other site 391595011388 NAD binding site [chemical binding]; other site 391595011389 catalytic site [active] 391595011390 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 391595011391 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391595011392 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 391595011393 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391595011394 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 391595011395 NAD binding site [chemical binding]; other site 391595011396 homotetramer interface [polypeptide binding]; other site 391595011397 homodimer interface [polypeptide binding]; other site 391595011398 active site 391595011399 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391595011400 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391595011401 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391595011402 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 391595011403 putative NAD(P) binding site [chemical binding]; other site 391595011404 active site 391595011405 putative substrate binding site [chemical binding]; other site 391595011406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595011407 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391595011408 DNA-binding site [nucleotide binding]; DNA binding site 391595011409 FCD domain; Region: FCD; pfam07729 391595011410 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391595011411 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391595011412 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391595011413 active site pocket [active] 391595011414 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391595011415 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391595011416 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391595011417 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 391595011418 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 391595011419 galactarate dehydratase; Region: galactar-dH20; TIGR03248 391595011420 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 391595011421 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595011422 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595011423 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391595011424 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 391595011425 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391595011426 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391595011427 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595011428 EamA-like transporter family; Region: EamA; pfam00892 391595011429 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391595011430 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391595011431 substrate binding site [chemical binding]; other site 391595011432 ATP binding site [chemical binding]; other site 391595011433 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595011434 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595011435 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391595011436 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595011437 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595011438 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391595011439 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595011440 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595011441 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391595011442 mannonate dehydratase; Provisional; Region: PRK03906 391595011443 mannonate dehydratase; Region: uxuA; TIGR00695 391595011444 RmuC family; Region: RmuC; pfam02646 391595011445 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 391595011446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595011447 ATP binding site [chemical binding]; other site 391595011448 Mg2+ binding site [ion binding]; other site 391595011449 G-X-G motif; other site 391595011450 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 391595011451 ATP binding site [chemical binding]; other site 391595011452 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 391595011453 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 391595011454 intersubunit interface [polypeptide binding]; other site 391595011455 active site 391595011456 catalytic residue [active] 391595011457 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 391595011458 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391595011459 NAD(P) binding site [chemical binding]; other site 391595011460 catalytic residues [active] 391595011461 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391595011462 NAD(P) binding site [chemical binding]; other site 391595011463 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391595011464 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391595011465 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391595011466 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391595011467 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391595011468 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 391595011469 lipoprotein signal peptidase; Provisional; Region: PRK14782 391595011470 lipoprotein signal peptidase; Provisional; Region: PRK14787 391595011471 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 391595011472 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 391595011473 purine monophosphate binding site [chemical binding]; other site 391595011474 dimer interface [polypeptide binding]; other site 391595011475 putative catalytic residues [active] 391595011476 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 391595011477 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 391595011478 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 391595011479 NusB family; Region: NusB; pfam01029 391595011480 putative RNA binding site [nucleotide binding]; other site 391595011481 16S rRNA methyltransferase B; Provisional; Region: PRK10901 391595011482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595011483 S-adenosylmethionine binding site [chemical binding]; other site 391595011484 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 391595011485 dihydrodipicolinate reductase; Provisional; Region: PRK00048 391595011486 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 391595011487 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 391595011488 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 391595011489 Predicted periplasmic protein [Function unknown]; Region: COG3698 391595011490 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 391595011491 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 391595011492 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 391595011493 RNA binding site [nucleotide binding]; other site 391595011494 active site 391595011495 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 391595011496 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 391595011497 16S/18S rRNA binding site [nucleotide binding]; other site 391595011498 S13e-L30e interaction site [polypeptide binding]; other site 391595011499 25S rRNA binding site [nucleotide binding]; other site 391595011500 4-aminobutyrate aminotransferase; Provisional; Region: PRK08360 391595011501 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391595011502 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391595011503 Ligand Binding Site [chemical binding]; other site 391595011504 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 391595011505 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 391595011506 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 391595011507 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391595011508 Zn2+ binding site [ion binding]; other site 391595011509 Mg2+ binding site [ion binding]; other site 391595011510 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 391595011511 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 391595011512 trimer interface [polypeptide binding]; other site 391595011513 RNase E interface [polypeptide binding]; other site 391595011514 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 391595011515 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 391595011516 RNase E interface [polypeptide binding]; other site 391595011517 trimer interface [polypeptide binding]; other site 391595011518 active site 391595011519 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 391595011520 putative nucleic acid binding region [nucleotide binding]; other site 391595011521 G-X-X-G motif; other site 391595011522 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 391595011523 RNA binding site [nucleotide binding]; other site 391595011524 domain interface; other site 391595011525 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 391595011526 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391595011527 active site 391595011528 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 391595011529 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 391595011530 dimer interface [polypeptide binding]; other site 391595011531 decamer (pentamer of dimers) interface [polypeptide binding]; other site 391595011532 catalytic triad [active] 391595011533 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 391595011534 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391595011535 NAD binding site [chemical binding]; other site 391595011536 catalytic residues [active] 391595011537 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 391595011538 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 391595011539 active site 391595011540 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595011541 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391595011542 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391595011543 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391595011544 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595011545 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 391595011546 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 391595011547 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391595011548 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391595011549 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391595011550 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595011551 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391595011552 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 391595011553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595011554 non-specific DNA binding site [nucleotide binding]; other site 391595011555 salt bridge; other site 391595011556 sequence-specific DNA binding site [nucleotide binding]; other site 391595011557 Cupin domain; Region: Cupin_2; pfam07883 391595011558 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 391595011559 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 391595011560 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391595011561 dimer interface [polypeptide binding]; other site 391595011562 active site 391595011563 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 391595011564 anti sigma factor interaction site; other site 391595011565 regulatory phosphorylation site [posttranslational modification]; other site 391595011566 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 391595011567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 391595011568 Mg2+ binding site [ion binding]; other site 391595011569 G-X-G motif; other site 391595011570 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 391595011571 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 391595011572 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 391595011573 Predicted permeases [General function prediction only]; Region: COG0679 391595011574 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391595011575 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391595011576 catalytic residue [active] 391595011577 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 391595011578 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 391595011579 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 391595011580 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 391595011581 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391595011582 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 391595011583 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 391595011584 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391595011585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595011586 homodimer interface [polypeptide binding]; other site 391595011587 catalytic residue [active] 391595011588 hypothetical protein; Provisional; Region: PRK06102 391595011589 Amidase; Region: Amidase; cl11426 391595011590 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391595011591 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 391595011592 Uncharacterized conserved protein [Function unknown]; Region: COG2835 391595011593 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 391595011594 GRIP domain; Region: GRIP; cl03225 391595011595 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 391595011596 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 391595011597 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391595011598 putative catalytic site [active] 391595011599 putative metal binding site [ion binding]; other site 391595011600 putative phosphate binding site [ion binding]; other site 391595011601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595011602 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391595011603 active site 391595011604 phosphorylation site [posttranslational modification] 391595011605 intermolecular recognition site; other site 391595011606 dimerization interface [polypeptide binding]; other site 391595011607 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391595011608 DNA binding site [nucleotide binding] 391595011609 GTP cyclohydrolase; Provisional; Region: PRK08815 391595011610 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 391595011611 dimerization interface [polypeptide binding]; other site 391595011612 active site 391595011613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 391595011614 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 391595011615 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391595011616 catalytic residue [active] 391595011617 Gram-negative porin; Region: Porin_4; pfam13609 391595011618 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 391595011619 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 391595011620 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 391595011621 HIGH motif; other site 391595011622 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 391595011623 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391595011624 active site 391595011625 KMSKS motif; other site 391595011626 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 391595011627 tRNA binding surface [nucleotide binding]; other site 391595011628 Lipopolysaccharide-assembly; Region: LptE; pfam04390 391595011629 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 391595011630 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 391595011631 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391595011632 putative C-terminal domain interface [polypeptide binding]; other site 391595011633 putative GSH binding site (G-site) [chemical binding]; other site 391595011634 putative dimer interface [polypeptide binding]; other site 391595011635 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391595011636 dimer interface [polypeptide binding]; other site 391595011637 N-terminal domain interface [polypeptide binding]; other site 391595011638 substrate binding pocket (H-site) [chemical binding]; other site 391595011639 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595011640 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 391595011641 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391595011642 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391595011643 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391595011644 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391595011645 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 391595011646 epoxyqueuosine reductase; Region: TIGR00276 391595011647 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 391595011648 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 391595011649 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391595011650 C-terminal domain interface [polypeptide binding]; other site 391595011651 GSH binding site (G-site) [chemical binding]; other site 391595011652 dimer interface [polypeptide binding]; other site 391595011653 Transglycosylase; Region: Transgly; cl17702 391595011654 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 391595011655 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 391595011656 active site 391595011657 dimer interface [polypeptide binding]; other site 391595011658 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 391595011659 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 391595011660 active site 391595011661 FMN binding site [chemical binding]; other site 391595011662 substrate binding site [chemical binding]; other site 391595011663 3Fe-4S cluster binding site [ion binding]; other site 391595011664 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 391595011665 domain interface; other site 391595011666 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391595011667 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391595011668 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 391595011669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595011670 Bacitracin resistance protein BacA; Region: BacA; pfam02673 391595011671 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 391595011672 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 391595011673 putative NAD(P) binding site [chemical binding]; other site 391595011674 active site 391595011675 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 391595011676 putative deacylase active site [active] 391595011677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 391595011678 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391595011679 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391595011680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391595011681 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391595011682 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391595011683 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391595011684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595011685 dimer interface [polypeptide binding]; other site 391595011686 conserved gate region; other site 391595011687 putative PBP binding loops; other site 391595011688 ABC-ATPase subunit interface; other site 391595011689 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 391595011690 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391595011691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595011692 Walker A/P-loop; other site 391595011693 ATP binding site [chemical binding]; other site 391595011694 Q-loop/lid; other site 391595011695 ABC transporter signature motif; other site 391595011696 Walker B; other site 391595011697 D-loop; other site 391595011698 H-loop/switch region; other site 391595011699 Putative transcription activator [Transcription]; Region: TenA; COG0819 391595011700 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 391595011701 NMT1/THI5 like; Region: NMT1; pfam09084 391595011702 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 391595011703 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 391595011704 ATP binding site [chemical binding]; other site 391595011705 substrate interface [chemical binding]; other site 391595011706 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391595011707 active site residue [active] 391595011708 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391595011709 active site 391595011710 thiamine phosphate binding site [chemical binding]; other site 391595011711 pyrophosphate binding site [ion binding]; other site 391595011712 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 391595011713 ThiS interaction site; other site 391595011714 putative active site [active] 391595011715 tetramer interface [polypeptide binding]; other site 391595011716 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 391595011717 thiS-thiF/thiG interaction site; other site 391595011718 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 391595011719 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 391595011720 dimer interface [polypeptide binding]; other site 391595011721 substrate binding site [chemical binding]; other site 391595011722 ATP binding site [chemical binding]; other site 391595011723 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595011724 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595011725 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391595011726 dimerization interface [polypeptide binding]; other site 391595011727 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391595011728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595011729 S-adenosylmethionine binding site [chemical binding]; other site 391595011730 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 391595011731 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391595011732 catalytic tetrad [active] 391595011733 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391595011734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595011735 non-specific DNA binding site [nucleotide binding]; other site 391595011736 salt bridge; other site 391595011737 sequence-specific DNA binding site [nucleotide binding]; other site 391595011738 siroheme synthase; Provisional; Region: cysG; PRK10637 391595011739 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 391595011740 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 391595011741 active site 391595011742 SAM binding site [chemical binding]; other site 391595011743 homodimer interface [polypeptide binding]; other site 391595011744 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 391595011745 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 391595011746 [4Fe-4S] binding site [ion binding]; other site 391595011747 molybdopterin cofactor binding site; other site 391595011748 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 391595011749 molybdopterin cofactor binding site; other site 391595011750 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 391595011751 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 391595011752 [2Fe-2S] cluster binding site [ion binding]; other site 391595011753 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 391595011754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595011755 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391595011756 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 391595011757 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391595011758 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391595011759 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391595011760 Walker A/P-loop; other site 391595011761 ATP binding site [chemical binding]; other site 391595011762 Q-loop/lid; other site 391595011763 ABC transporter signature motif; other site 391595011764 Walker B; other site 391595011765 D-loop; other site 391595011766 H-loop/switch region; other site 391595011767 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391595011768 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391595011769 Walker A/P-loop; other site 391595011770 ATP binding site [chemical binding]; other site 391595011771 Q-loop/lid; other site 391595011772 ABC transporter signature motif; other site 391595011773 Walker B; other site 391595011774 D-loop; other site 391595011775 H-loop/switch region; other site 391595011776 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391595011777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595011778 dimer interface [polypeptide binding]; other site 391595011779 conserved gate region; other site 391595011780 putative PBP binding loops; other site 391595011781 ABC-ATPase subunit interface; other site 391595011782 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391595011783 NMT1-like family; Region: NMT1_2; pfam13379 391595011784 NMT1-like family; Region: NMT1_2; pfam13379 391595011785 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391595011786 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 391595011787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 391595011788 active site 391595011789 phosphorylation site [posttranslational modification] 391595011790 intermolecular recognition site; other site 391595011791 dimerization interface [polypeptide binding]; other site 391595011792 ANTAR domain; Region: ANTAR; pfam03861 391595011793 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 391595011794 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 391595011795 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391595011796 Coenzyme A binding pocket [chemical binding]; other site 391595011797 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391595011798 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391595011799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595011800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595011801 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391595011802 putative effector binding pocket; other site 391595011803 dimerization interface [polypeptide binding]; other site 391595011804 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 391595011805 Isochorismatase family; Region: Isochorismatase; pfam00857 391595011806 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 391595011807 catalytic triad [active] 391595011808 conserved cis-peptide bond; other site 391595011809 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391595011810 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391595011811 Walker A/P-loop; other site 391595011812 ATP binding site [chemical binding]; other site 391595011813 Q-loop/lid; other site 391595011814 ABC transporter signature motif; other site 391595011815 Walker B; other site 391595011816 D-loop; other site 391595011817 H-loop/switch region; other site 391595011818 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391595011819 Isochorismatase family; Region: Isochorismatase; pfam00857 391595011820 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 391595011821 catalytic triad [active] 391595011822 conserved cis-peptide bond; other site 391595011823 formamidase; Provisional; Region: amiF; PRK13287 391595011824 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 391595011825 multimer interface [polypeptide binding]; other site 391595011826 active site 391595011827 catalytic triad [active] 391595011828 dimer interface [polypeptide binding]; other site 391595011829 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595011830 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391595011831 TM-ABC transporter signature motif; other site 391595011832 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595011833 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391595011834 TM-ABC transporter signature motif; other site 391595011835 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391595011836 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 391595011837 putative ligand binding site [chemical binding]; other site 391595011838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595011839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595011840 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391595011841 dimerization interface [polypeptide binding]; other site 391595011842 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 391595011843 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391595011844 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391595011845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391595011846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595011847 ABC-ATPase subunit interface; other site 391595011848 putative PBP binding loops; other site 391595011849 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391595011850 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391595011851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595011852 dimer interface [polypeptide binding]; other site 391595011853 conserved gate region; other site 391595011854 putative PBP binding loops; other site 391595011855 ABC-ATPase subunit interface; other site 391595011856 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391595011857 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595011858 Walker A/P-loop; other site 391595011859 ATP binding site [chemical binding]; other site 391595011860 Q-loop/lid; other site 391595011861 ABC transporter signature motif; other site 391595011862 Walker B; other site 391595011863 D-loop; other site 391595011864 H-loop/switch region; other site 391595011865 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391595011866 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391595011867 Walker A/P-loop; other site 391595011868 ATP binding site [chemical binding]; other site 391595011869 Q-loop/lid; other site 391595011870 ABC transporter signature motif; other site 391595011871 Walker B; other site 391595011872 D-loop; other site 391595011873 H-loop/switch region; other site 391595011874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391595011875 allophanate hydrolase; Provisional; Region: PRK08186 391595011876 Amidase; Region: Amidase; cl11426 391595011877 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 391595011878 homotrimer interaction site [polypeptide binding]; other site 391595011879 putative active site [active] 391595011880 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391595011881 Amidase; Region: Amidase; cl11426 391595011882 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 391595011883 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 391595011884 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 391595011885 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 391595011886 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391595011887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595011888 active site 391595011889 phosphorylation site [posttranslational modification] 391595011890 intermolecular recognition site; other site 391595011891 dimerization interface [polypeptide binding]; other site 391595011892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391595011893 DNA binding site [nucleotide binding] 391595011894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391595011895 HAMP domain; Region: HAMP; pfam00672 391595011896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595011897 dimer interface [polypeptide binding]; other site 391595011898 phosphorylation site [posttranslational modification] 391595011899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595011900 ATP binding site [chemical binding]; other site 391595011901 Mg2+ binding site [ion binding]; other site 391595011902 G-X-G motif; other site 391595011903 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595011904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595011905 ABC transporter signature motif; other site 391595011906 Walker B; other site 391595011907 D-loop; other site 391595011908 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391595011909 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 391595011910 Ca2+ binding site [ion binding]; other site 391595011911 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595011912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391595011913 ABC-ATPase subunit interface; other site 391595011914 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391595011915 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391595011916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 391595011917 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 391595011918 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 391595011919 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 391595011920 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 391595011921 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391595011922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595011923 FeS/SAM binding site; other site 391595011924 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 391595011925 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391595011926 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595011927 ligand binding site [chemical binding]; other site 391595011928 flexible hinge region; other site 391595011929 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 391595011930 non-specific DNA interactions [nucleotide binding]; other site 391595011931 DNA binding site [nucleotide binding] 391595011932 sequence specific DNA binding site [nucleotide binding]; other site 391595011933 putative cAMP binding site [chemical binding]; other site 391595011934 cytochrome c-550; Provisional; Region: psbV; cl17239 391595011935 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 391595011936 cytochrome b; Provisional; Region: CYTB; MTH00191 391595011937 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 391595011938 intrachain domain interface; other site 391595011939 interchain domain interface [polypeptide binding]; other site 391595011940 heme bH binding site [chemical binding]; other site 391595011941 Qi binding site; other site 391595011942 heme bL binding site [chemical binding]; other site 391595011943 Qo binding site; other site 391595011944 interchain domain interface [polypeptide binding]; other site 391595011945 intrachain domain interface; other site 391595011946 Qi binding site; other site 391595011947 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 391595011948 Qo binding site; other site 391595011949 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 391595011950 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 391595011951 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 391595011952 [2Fe-2S] cluster binding site [ion binding]; other site 391595011953 putative glutathione S-transferase; Provisional; Region: PRK10357 391595011954 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391595011955 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 391595011956 dimer interface [polypeptide binding]; other site 391595011957 N-terminal domain interface [polypeptide binding]; other site 391595011958 putative substrate binding pocket (H-site) [chemical binding]; other site 391595011959 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 391595011960 riboflavin synthase subunit beta; Provisional; Region: PRK12419 391595011961 active site 391595011962 homopentamer interface [polypeptide binding]; other site 391595011963 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 391595011964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595011965 Walker A/P-loop; other site 391595011966 ATP binding site [chemical binding]; other site 391595011967 Q-loop/lid; other site 391595011968 ABC transporter signature motif; other site 391595011969 Walker B; other site 391595011970 D-loop; other site 391595011971 H-loop/switch region; other site 391595011972 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 391595011973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595011974 dimer interface [polypeptide binding]; other site 391595011975 conserved gate region; other site 391595011976 putative PBP binding loops; other site 391595011977 ABC-ATPase subunit interface; other site 391595011978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595011979 conserved gate region; other site 391595011980 putative PBP binding loops; other site 391595011981 ABC-ATPase subunit interface; other site 391595011982 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391595011983 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 391595011984 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 391595011985 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 391595011986 Tetramer interface [polypeptide binding]; other site 391595011987 active site 391595011988 FMN-binding site [chemical binding]; other site 391595011989 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595011990 EamA-like transporter family; Region: EamA; pfam00892 391595011991 EamA-like transporter family; Region: EamA; cl17759 391595011992 SnoaL-like domain; Region: SnoaL_2; pfam12680 391595011993 branched-chain amino acid aminotransferase; Validated; Region: PRK07544 391595011994 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391595011995 homodimer interface [polypeptide binding]; other site 391595011996 substrate-cofactor binding pocket; other site 391595011997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595011998 catalytic residue [active] 391595011999 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391595012000 MarR family; Region: MarR_2; pfam12802 391595012001 osmolarity response regulator; Provisional; Region: ompR; PRK09468 391595012002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595012003 active site 391595012004 phosphorylation site [posttranslational modification] 391595012005 intermolecular recognition site; other site 391595012006 dimerization interface [polypeptide binding]; other site 391595012007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391595012008 DNA binding site [nucleotide binding] 391595012009 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 391595012010 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 391595012011 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391595012012 substrate binding pocket [chemical binding]; other site 391595012013 chain length determination region; other site 391595012014 substrate-Mg2+ binding site; other site 391595012015 catalytic residues [active] 391595012016 aspartate-rich region 1; other site 391595012017 active site lid residues [active] 391595012018 aspartate-rich region 2; other site 391595012019 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 391595012020 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 391595012021 TPP-binding site; other site 391595012022 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391595012023 PYR/PP interface [polypeptide binding]; other site 391595012024 dimer interface [polypeptide binding]; other site 391595012025 TPP binding site [chemical binding]; other site 391595012026 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391595012027 bile acid transporter; Region: bass; TIGR00841 391595012028 Sodium Bile acid symporter family; Region: SBF; cl17470 391595012029 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 391595012030 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391595012031 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 391595012032 acyl-activating enzyme (AAE) consensus motif; other site 391595012033 putative AMP binding site [chemical binding]; other site 391595012034 putative active site [active] 391595012035 putative CoA binding site [chemical binding]; other site 391595012036 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 391595012037 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391595012038 Zn binding site [ion binding]; other site 391595012039 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 391595012040 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391595012041 Zn binding site [ion binding]; other site 391595012042 Predicted esterase [General function prediction only]; Region: COG0400 391595012043 Serine hydrolase (FSH1); Region: FSH1; pfam03959 391595012044 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391595012045 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391595012046 Walker A/P-loop; other site 391595012047 ATP binding site [chemical binding]; other site 391595012048 Q-loop/lid; other site 391595012049 ABC transporter signature motif; other site 391595012050 Walker B; other site 391595012051 D-loop; other site 391595012052 H-loop/switch region; other site 391595012053 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391595012054 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391595012055 Walker A/P-loop; other site 391595012056 ATP binding site [chemical binding]; other site 391595012057 Q-loop/lid; other site 391595012058 ABC transporter signature motif; other site 391595012059 Walker B; other site 391595012060 D-loop; other site 391595012061 H-loop/switch region; other site 391595012062 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391595012063 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391595012064 TM-ABC transporter signature motif; other site 391595012065 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391595012066 TM-ABC transporter signature motif; other site 391595012067 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391595012068 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 391595012069 putative ligand binding site [chemical binding]; other site 391595012070 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 391595012071 dimer interface [polypeptide binding]; other site 391595012072 ADP-ribose binding site [chemical binding]; other site 391595012073 active site 391595012074 nudix motif; other site 391595012075 metal binding site [ion binding]; metal-binding site 391595012076 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 391595012077 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 391595012078 FAD dependent oxidoreductase; Region: DAO; pfam01266 391595012079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391595012080 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391595012081 active site residue [active] 391595012082 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391595012083 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 391595012084 putative hydrophobic ligand binding site [chemical binding]; other site 391595012085 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391595012086 Sulfatase; Region: Sulfatase; pfam00884 391595012087 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 391595012088 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391595012089 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 391595012090 MoxR-like ATPases [General function prediction only]; Region: COG0714 391595012091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595012092 Walker A motif; other site 391595012093 ATP binding site [chemical binding]; other site 391595012094 Walker B motif; other site 391595012095 arginine finger; other site 391595012096 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 391595012097 Protein of unknown function DUF58; Region: DUF58; pfam01882 391595012098 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 391595012099 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391595012100 metal ion-dependent adhesion site (MIDAS); other site 391595012101 von Willebrand factor type A domain; Region: VWA_2; pfam13519 391595012102 metal ion-dependent adhesion site (MIDAS); other site 391595012103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391595012104 Tetratricopeptide repeat; Region: TPR_16; pfam13432 391595012105 TPR motif; other site 391595012106 binding surface 391595012107 Oxygen tolerance; Region: BatD; pfam13584 391595012108 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 391595012109 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 391595012110 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 391595012111 HEAT repeats; Region: HEAT_2; pfam13646 391595012112 Tetratricopeptide repeat; Region: TPR_16; pfam13432 391595012113 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595012114 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391595012115 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595012116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595012117 dimer interface [polypeptide binding]; other site 391595012118 conserved gate region; other site 391595012119 putative PBP binding loops; other site 391595012120 ABC-ATPase subunit interface; other site 391595012121 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595012122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595012123 dimer interface [polypeptide binding]; other site 391595012124 conserved gate region; other site 391595012125 putative PBP binding loops; other site 391595012126 ABC-ATPase subunit interface; other site 391595012127 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391595012128 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391595012129 Walker A/P-loop; other site 391595012130 ATP binding site [chemical binding]; other site 391595012131 Q-loop/lid; other site 391595012132 ABC transporter signature motif; other site 391595012133 Walker B; other site 391595012134 D-loop; other site 391595012135 H-loop/switch region; other site 391595012136 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391595012137 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595012138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595012139 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 391595012140 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391595012141 NAD(P) binding site [chemical binding]; other site 391595012142 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 391595012143 choline dehydrogenase; Validated; Region: PRK02106 391595012144 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391595012145 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391595012146 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391595012147 active site 391595012148 catalytic tetrad [active] 391595012149 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 391595012150 Coenzyme A transferase; Region: CoA_trans; smart00882 391595012151 Coenzyme A transferase; Region: CoA_trans; cl17247 391595012152 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 391595012153 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391595012154 substrate binding site [chemical binding]; other site 391595012155 oxyanion hole (OAH) forming residues; other site 391595012156 trimer interface [polypeptide binding]; other site 391595012157 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 391595012158 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 391595012159 active site 391595012160 catalytic site [active] 391595012161 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391595012162 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391595012163 active site 391595012164 catalytic tetrad [active] 391595012165 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391595012166 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391595012167 active site 391595012168 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 391595012169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595012170 NAD(P) binding site [chemical binding]; other site 391595012171 active site 391595012172 Protein of unknown function (DUF993); Region: DUF993; pfam06187 391595012173 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391595012174 CHASE2 domain; Region: CHASE2; pfam05226 391595012175 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 391595012176 cyclase homology domain; Region: CHD; cd07302 391595012177 nucleotidyl binding site; other site 391595012178 metal binding site [ion binding]; metal-binding site 391595012179 dimer interface [polypeptide binding]; other site 391595012180 FecR protein; Region: FecR; pfam04773 391595012181 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391595012182 putative catalytic site [active] 391595012183 putative metal binding site [ion binding]; other site 391595012184 putative phosphate binding site [ion binding]; other site 391595012185 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 391595012186 Fasciclin domain; Region: Fasciclin; pfam02469 391595012187 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391595012188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391595012189 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391595012190 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391595012191 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391595012192 DNA binding site [nucleotide binding] 391595012193 domain linker motif; other site 391595012194 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 391595012195 putative dimerization interface [polypeptide binding]; other site 391595012196 putative ligand binding site [chemical binding]; other site 391595012197 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 391595012198 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391595012199 putative ligand binding site [chemical binding]; other site 391595012200 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391595012201 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391595012202 TM-ABC transporter signature motif; other site 391595012203 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391595012204 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391595012205 Walker A/P-loop; other site 391595012206 ATP binding site [chemical binding]; other site 391595012207 Q-loop/lid; other site 391595012208 ABC transporter signature motif; other site 391595012209 Walker B; other site 391595012210 D-loop; other site 391595012211 H-loop/switch region; other site 391595012212 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 391595012213 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 391595012214 EamA-like transporter family; Region: EamA; cl17759 391595012215 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 391595012216 RES domain; Region: RES; smart00953 391595012217 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595012218 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391595012219 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 391595012220 enoyl-CoA hydratase; Validated; Region: PRK08139 391595012221 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391595012222 substrate binding site [chemical binding]; other site 391595012223 oxyanion hole (OAH) forming residues; other site 391595012224 trimer interface [polypeptide binding]; other site 391595012225 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 391595012226 Fatty acid desaturase; Region: FA_desaturase; pfam00487 391595012227 putative di-iron ligands [ion binding]; other site 391595012228 Helix-turn-helix domain; Region: HTH_19; pfam12844 391595012229 HemY protein N-terminus; Region: HemY_N; pfam07219 391595012230 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 391595012231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 391595012232 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 391595012233 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 391595012234 active site 391595012235 UGMP family protein; Validated; Region: PRK09604 391595012236 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 391595012237 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 391595012238 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 391595012239 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 391595012240 YciI-like protein; Reviewed; Region: PRK12863 391595012241 EVE domain; Region: EVE; pfam01878 391595012242 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 391595012243 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 391595012244 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 391595012245 homotetramer interface [polypeptide binding]; other site 391595012246 ligand binding site [chemical binding]; other site 391595012247 catalytic site [active] 391595012248 NAD binding site [chemical binding]; other site 391595012249 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 391595012250 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 391595012251 Ligand binding site; other site 391595012252 metal-binding site 391595012253 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 391595012254 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391595012255 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 391595012256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595012257 active site 391595012258 phosphorylation site [posttranslational modification] 391595012259 intermolecular recognition site; other site 391595012260 dimerization interface [polypeptide binding]; other site 391595012261 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 391595012262 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 391595012263 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 391595012264 Cu(I) binding site [ion binding]; other site 391595012265 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391595012266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595012267 dimer interface [polypeptide binding]; other site 391595012268 phosphorylation site [posttranslational modification] 391595012269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595012270 ATP binding site [chemical binding]; other site 391595012271 Mg2+ binding site [ion binding]; other site 391595012272 G-X-G motif; other site 391595012273 PAS fold; Region: PAS_7; pfam12860 391595012274 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 391595012275 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 391595012276 Phosphotransferase enzyme family; Region: APH; pfam01636 391595012277 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 391595012278 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 391595012279 Substrate binding site; other site 391595012280 metal-binding site 391595012281 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 391595012282 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 391595012283 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 391595012284 Part of AAA domain; Region: AAA_19; pfam13245 391595012285 Family description; Region: UvrD_C_2; pfam13538 391595012286 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 391595012287 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 391595012288 catalytic residues [active] 391595012289 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 391595012290 active site 391595012291 HslU subunit interaction site [polypeptide binding]; other site 391595012292 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 391595012293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595012294 Walker A motif; other site 391595012295 ATP binding site [chemical binding]; other site 391595012296 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 391595012297 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 391595012298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595012299 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391595012300 putative substrate translocation pore; other site 391595012301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 391595012302 Smr domain; Region: Smr; pfam01713 391595012303 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 391595012304 MltA specific insert domain; Region: MltA; smart00925 391595012305 3D domain; Region: 3D; pfam06725 391595012306 Tim44-like domain; Region: Tim44; pfam04280 391595012307 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 391595012308 Preprotein translocase subunit SecB; Region: SecB; pfam02556 391595012309 SecA binding site; other site 391595012310 Preprotein binding site; other site 391595012311 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 391595012312 active site 391595012313 catalytic site [active] 391595012314 substrate binding site [chemical binding]; other site 391595012315 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 391595012316 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 391595012317 CoA-binding site [chemical binding]; other site 391595012318 ATP-binding [chemical binding]; other site 391595012319 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 391595012320 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 391595012321 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 391595012322 shikimate binding site; other site 391595012323 NAD(P) binding site [chemical binding]; other site 391595012324 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 391595012325 putative active site [active] 391595012326 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 391595012327 transcription termination factor Rho; Provisional; Region: rho; PRK09376 391595012328 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 391595012329 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 391595012330 RNA binding site [nucleotide binding]; other site 391595012331 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 391595012332 multimer interface [polypeptide binding]; other site 391595012333 Walker A motif; other site 391595012334 ATP binding site [chemical binding]; other site 391595012335 Walker B motif; other site 391595012336 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 391595012337 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 391595012338 trmE is a tRNA modification GTPase; Region: trmE; cd04164 391595012339 G1 box; other site 391595012340 GTP/Mg2+ binding site [chemical binding]; other site 391595012341 Switch I region; other site 391595012342 G2 box; other site 391595012343 Switch II region; other site 391595012344 G3 box; other site 391595012345 G4 box; other site 391595012346 G5 box; other site 391595012347 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 391595012348 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 391595012349 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 391595012350 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 391595012351 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 391595012352 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 391595012353 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 391595012354 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391595012355 P-loop; other site 391595012356 Magnesium ion binding site [ion binding]; other site 391595012357 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391595012358 Magnesium ion binding site [ion binding]; other site 391595012359 ParB-like nuclease domain; Region: ParBc; pfam02195 391595012360 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 391595012361 KorB domain; Region: KorB; pfam08535 391595012362 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 391595012363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595012364 FeS/SAM binding site; other site 391595012365 HemN C-terminal domain; Region: HemN_C; pfam06969 391595012366 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 391595012367 active site 391595012368 dimerization interface [polypeptide binding]; other site 391595012369 ribonuclease PH; Reviewed; Region: rph; PRK00173 391595012370 Ribonuclease PH; Region: RNase_PH_bact; cd11362 391595012371 hexamer interface [polypeptide binding]; other site 391595012372 active site 391595012373 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 391595012374 GrpE; Region: GrpE; pfam01025 391595012375 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 391595012376 dimer interface [polypeptide binding]; other site 391595012377 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 391595012378 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 391595012379 MutS domain I; Region: MutS_I; pfam01624 391595012380 MutS domain II; Region: MutS_II; pfam05188 391595012381 MutS domain III; Region: MutS_III; pfam05192 391595012382 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 391595012383 Walker A/P-loop; other site 391595012384 ATP binding site [chemical binding]; other site 391595012385 Q-loop/lid; other site 391595012386 ABC transporter signature motif; other site 391595012387 Walker B; other site 391595012388 D-loop; other site 391595012389 H-loop/switch region; other site 391595012390 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 391595012391 Malic enzyme, N-terminal domain; Region: malic; pfam00390 391595012392 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 391595012393 putative NAD(P) binding site [chemical binding]; other site 391595012394 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 391595012395 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 391595012396 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391595012397 substrate binding site [chemical binding]; other site 391595012398 dimer interface [polypeptide binding]; other site 391595012399 ATP binding site [chemical binding]; other site 391595012400 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 391595012401 argininosuccinate synthase; Provisional; Region: PRK13820 391595012402 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 391595012403 ANP binding site [chemical binding]; other site 391595012404 Substrate Binding Site II [chemical binding]; other site 391595012405 Substrate Binding Site I [chemical binding]; other site 391595012406 threonine dehydratase; Validated; Region: PRK08639 391595012407 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391595012408 tetramer interface [polypeptide binding]; other site 391595012409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595012410 catalytic residue [active] 391595012411 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 391595012412 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391595012413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595012414 NAD(P) binding site [chemical binding]; other site 391595012415 active site 391595012416 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 391595012417 putative binding surface; other site 391595012418 active site 391595012419 Response regulator receiver domain; Region: Response_reg; pfam00072 391595012420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595012421 active site 391595012422 phosphorylation site [posttranslational modification] 391595012423 intermolecular recognition site; other site 391595012424 dimerization interface [polypeptide binding]; other site 391595012425 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 391595012426 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 391595012427 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 391595012428 nudix motif; other site 391595012429 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 391595012430 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 391595012431 dimerization interface [polypeptide binding]; other site 391595012432 domain crossover interface; other site 391595012433 redox-dependent activation switch; other site 391595012434 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 391595012435 putative active site [active] 391595012436 putative CoA binding site [chemical binding]; other site 391595012437 nudix motif; other site 391595012438 metal binding site [ion binding]; metal-binding site 391595012439 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 391595012440 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 391595012441 active site 391595012442 NTP binding site [chemical binding]; other site 391595012443 metal binding triad [ion binding]; metal-binding site 391595012444 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 391595012445 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391595012446 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595012447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595012448 Walker A/P-loop; other site 391595012449 ATP binding site [chemical binding]; other site 391595012450 Q-loop/lid; other site 391595012451 ABC transporter signature motif; other site 391595012452 Walker B; other site 391595012453 D-loop; other site 391595012454 H-loop/switch region; other site 391595012455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391595012456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595012457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595012458 Walker A/P-loop; other site 391595012459 ATP binding site [chemical binding]; other site 391595012460 Q-loop/lid; other site 391595012461 ABC transporter signature motif; other site 391595012462 Walker B; other site 391595012463 D-loop; other site 391595012464 H-loop/switch region; other site 391595012465 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 391595012466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595012467 S-adenosylmethionine binding site [chemical binding]; other site 391595012468 Ion transport protein; Region: Ion_trans; pfam00520 391595012469 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391595012470 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 391595012471 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391595012472 ferrochelatase; Reviewed; Region: hemH; PRK00035 391595012473 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 391595012474 C-terminal domain interface [polypeptide binding]; other site 391595012475 active site 391595012476 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 391595012477 active site 391595012478 N-terminal domain interface [polypeptide binding]; other site 391595012479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391595012480 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 391595012481 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 391595012482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391595012483 active site 391595012484 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 391595012485 GSH binding site [chemical binding]; other site 391595012486 catalytic residues [active] 391595012487 nitrilase; Region: PLN02798 391595012488 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 391595012489 putative active site [active] 391595012490 catalytic triad [active] 391595012491 dimer interface [polypeptide binding]; other site 391595012492 MarR family; Region: MarR_2; pfam12802 391595012493 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 391595012494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595012495 S-adenosylmethionine binding site [chemical binding]; other site 391595012496 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 391595012497 Serine hydrolase; Region: Ser_hydrolase; cl17834 391595012498 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 391595012499 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391595012500 ribosome maturation protein RimP; Reviewed; Region: PRK00092 391595012501 Sm and related proteins; Region: Sm_like; cl00259 391595012502 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 391595012503 putative oligomer interface [polypeptide binding]; other site 391595012504 putative RNA binding site [nucleotide binding]; other site 391595012505 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 391595012506 NusA N-terminal domain; Region: NusA_N; pfam08529 391595012507 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 391595012508 RNA binding site [nucleotide binding]; other site 391595012509 homodimer interface [polypeptide binding]; other site 391595012510 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 391595012511 G-X-X-G motif; other site 391595012512 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 391595012513 G-X-X-G motif; other site 391595012514 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 391595012515 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391595012516 hypothetical protein; Provisional; Region: PRK09190 391595012517 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 391595012518 putative RNA binding cleft [nucleotide binding]; other site 391595012519 translation initiation factor IF-2; Region: IF-2; TIGR00487 391595012520 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 391595012521 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 391595012522 G1 box; other site 391595012523 putative GEF interaction site [polypeptide binding]; other site 391595012524 GTP/Mg2+ binding site [chemical binding]; other site 391595012525 Switch I region; other site 391595012526 G2 box; other site 391595012527 G3 box; other site 391595012528 Switch II region; other site 391595012529 G4 box; other site 391595012530 G5 box; other site 391595012531 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 391595012532 Translation-initiation factor 2; Region: IF-2; pfam11987 391595012533 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 391595012534 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 391595012535 active site 391595012536 8-oxo-dGMP binding site [chemical binding]; other site 391595012537 nudix motif; other site 391595012538 metal binding site [ion binding]; metal-binding site 391595012539 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 391595012540 heterotetramer interface [polypeptide binding]; other site 391595012541 active site pocket [active] 391595012542 cleavage site 391595012543 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 391595012544 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 391595012545 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 391595012546 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 391595012547 nucleotide binding region [chemical binding]; other site 391595012548 ATP-binding site [chemical binding]; other site 391595012549 SEC-C motif; Region: SEC-C; pfam02810 391595012550 PBP superfamily domain; Region: PBP_like_2; cl17296 391595012551 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391595012552 ligand binding site [chemical binding]; other site 391595012553 hypothetical protein; Reviewed; Region: PRK00024 391595012554 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 391595012555 MPN+ (JAMM) motif; other site 391595012556 Zinc-binding site [ion binding]; other site 391595012557 chaperone protein DnaJ; Provisional; Region: PRK10767 391595012558 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391595012559 HSP70 interaction site [polypeptide binding]; other site 391595012560 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 391595012561 substrate binding site [polypeptide binding]; other site 391595012562 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 391595012563 Zn binding sites [ion binding]; other site 391595012564 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 391595012565 dimer interface [polypeptide binding]; other site 391595012566 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 391595012567 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 391595012568 nucleotide binding site [chemical binding]; other site 391595012569 NEF interaction site [polypeptide binding]; other site 391595012570 SBD interface [polypeptide binding]; other site 391595012571 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 391595012572 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 391595012573 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391595012574 active site 391595012575 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 391595012576 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 391595012577 Ligand binding site; other site 391595012578 oligomer interface; other site 391595012579 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 391595012580 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 391595012581 active site 391595012582 tetramer interface; other site 391595012583 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 391595012584 active site 391595012585 phosphorylation site [posttranslational modification] 391595012586 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 391595012587 30S subunit binding site; other site 391595012588 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 391595012589 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 391595012590 Walker A/P-loop; other site 391595012591 ATP binding site [chemical binding]; other site 391595012592 Q-loop/lid; other site 391595012593 ABC transporter signature motif; other site 391595012594 Walker B; other site 391595012595 D-loop; other site 391595012596 H-loop/switch region; other site 391595012597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 391595012598 OstA-like protein; Region: OstA; pfam03968 391595012599 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 391595012600 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 391595012601 putative active site [active] 391595012602 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 391595012603 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 391595012604 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 391595012605 catalytic site [active] 391595012606 putative active site [active] 391595012607 putative substrate binding site [chemical binding]; other site 391595012608 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391595012609 EamA-like transporter family; Region: EamA; pfam00892 391595012610 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 391595012611 hypothetical protein; Provisional; Region: PRK09256 391595012612 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 391595012613 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 391595012614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 391595012615 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 391595012616 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 391595012617 YGGT family; Region: YGGT; pfam02325 391595012618 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 391595012619 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391595012620 ATP binding site [chemical binding]; other site 391595012621 putative Mg++ binding site [ion binding]; other site 391595012622 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391595012623 nucleotide binding region [chemical binding]; other site 391595012624 ATP-binding site [chemical binding]; other site 391595012625 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 391595012626 HRDC domain; Region: HRDC; pfam00570 391595012627 hypothetical protein; Validated; Region: PRK02101 391595012628 PAS fold; Region: PAS_7; pfam12860 391595012629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391595012630 dimer interface [polypeptide binding]; other site 391595012631 phosphorylation site [posttranslational modification] 391595012632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391595012633 ATP binding site [chemical binding]; other site 391595012634 Mg2+ binding site [ion binding]; other site 391595012635 G-X-G motif; other site 391595012636 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391595012637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595012638 active site 391595012639 phosphorylation site [posttranslational modification] 391595012640 intermolecular recognition site; other site 391595012641 Response regulator receiver domain; Region: Response_reg; pfam00072 391595012642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595012643 active site 391595012644 phosphorylation site [posttranslational modification] 391595012645 intermolecular recognition site; other site 391595012646 dimerization interface [polypeptide binding]; other site 391595012647 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 391595012648 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 391595012649 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 391595012650 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 391595012651 Protein of unknown function DUF58; Region: DUF58; pfam01882 391595012652 MoxR-like ATPases [General function prediction only]; Region: COG0714 391595012653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391595012654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 391595012655 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 391595012656 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 391595012657 DNA polymerase I; Provisional; Region: PRK05755 391595012658 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 391595012659 active site 391595012660 metal binding site 1 [ion binding]; metal-binding site 391595012661 putative 5' ssDNA interaction site; other site 391595012662 metal binding site 3; metal-binding site 391595012663 metal binding site 2 [ion binding]; metal-binding site 391595012664 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 391595012665 putative DNA binding site [nucleotide binding]; other site 391595012666 putative metal binding site [ion binding]; other site 391595012667 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 391595012668 active site 391595012669 catalytic site [active] 391595012670 substrate binding site [chemical binding]; other site 391595012671 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 391595012672 active site 391595012673 DNA binding site [nucleotide binding] 391595012674 catalytic site [active] 391595012675 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 391595012676 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 391595012677 putative active site [active] 391595012678 putative PHP Thumb interface [polypeptide binding]; other site 391595012679 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 391595012680 phosphoglyceromutase; Provisional; Region: PRK05434 391595012681 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 391595012682 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 391595012683 Peptidase family M23; Region: Peptidase_M23; pfam01551 391595012684 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 391595012685 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 391595012686 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 391595012687 protein binding site [polypeptide binding]; other site 391595012688 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 391595012689 Catalytic dyad [active] 391595012690 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 391595012691 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391595012692 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391595012693 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 391595012694 Q-loop/lid; other site 391595012695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595012696 ABC transporter signature motif; other site 391595012697 Walker B; other site 391595012698 D-loop; other site 391595012699 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391595012700 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595012701 ligand binding site [chemical binding]; other site 391595012702 flexible hinge region; other site 391595012703 CAAX protease self-immunity; Region: Abi; pfam02517 391595012704 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 391595012705 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 391595012706 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 391595012707 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 391595012708 Predicted ATPase [General function prediction only]; Region: COG1485 391595012709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595012710 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391595012711 putative substrate translocation pore; other site 391595012712 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391595012713 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391595012714 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 391595012715 nucleophilic elbow; other site 391595012716 catalytic triad; other site 391595012717 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 391595012718 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391595012719 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 391595012720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595012721 motif II; other site 391595012722 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 391595012723 S-formylglutathione hydrolase; Region: PLN02442 391595012724 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 391595012725 Predicted permeases [General function prediction only]; Region: COG0679 391595012726 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595012727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595012728 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 391595012729 DNA Polymerase Y-family; Region: PolY_like; cd03468 391595012730 active site 391595012731 DNA binding site [nucleotide binding] 391595012732 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 391595012733 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 391595012734 NlpC/P60 family; Region: NLPC_P60; cl17555 391595012735 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 391595012736 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 391595012737 interface (dimer of trimers) [polypeptide binding]; other site 391595012738 Substrate-binding/catalytic site; other site 391595012739 Zn-binding sites [ion binding]; other site 391595012740 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 391595012741 active site clefts [active] 391595012742 zinc binding site [ion binding]; other site 391595012743 dimer interface [polypeptide binding]; other site 391595012744 Domain of unknown function (DUF897); Region: DUF897; pfam05982 391595012745 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 391595012746 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 391595012747 active site 391595012748 catalytic site [active] 391595012749 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 391595012750 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 391595012751 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 391595012752 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 391595012753 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 391595012754 RNA/DNA hybrid binding site [nucleotide binding]; other site 391595012755 active site 391595012756 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 391595012757 DNA methylase; Region: N6_N4_Mtase; pfam01555 391595012758 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 391595012759 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391595012760 minor groove reading motif; other site 391595012761 helix-hairpin-helix signature motif; other site 391595012762 substrate binding pocket [chemical binding]; other site 391595012763 active site 391595012764 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 391595012765 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 391595012766 DNA binding and oxoG recognition site [nucleotide binding] 391595012767 Protein of unknown function (DUF721); Region: DUF721; cl02324 391595012768 Thioredoxin; Region: Thioredoxin_4; pfam13462 391595012769 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 391595012770 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 391595012771 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 391595012772 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 391595012773 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 391595012774 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 391595012775 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391595012776 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 391595012777 active site 391595012778 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 391595012779 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 391595012780 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 391595012781 classical (c) SDRs; Region: SDR_c; cd05233 391595012782 NAD(P) binding site [chemical binding]; other site 391595012783 active site 391595012784 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 391595012785 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391595012786 substrate binding site [chemical binding]; other site 391595012787 oxyanion hole (OAH) forming residues; other site 391595012788 trimer interface [polypeptide binding]; other site 391595012789 CCC1-related family of proteins; Region: CCC1_like; cl00278 391595012790 H+ Antiporter protein; Region: 2A0121; TIGR00900 391595012791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595012792 putative substrate translocation pore; other site 391595012793 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 391595012794 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 391595012795 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595012796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 391595012797 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391595012798 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 391595012799 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 391595012800 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 391595012801 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391595012802 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391595012803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595012804 dimer interface [polypeptide binding]; other site 391595012805 conserved gate region; other site 391595012806 putative PBP binding loops; other site 391595012807 ABC-ATPase subunit interface; other site 391595012808 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595012809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595012810 dimer interface [polypeptide binding]; other site 391595012811 conserved gate region; other site 391595012812 putative PBP binding loops; other site 391595012813 ABC-ATPase subunit interface; other site 391595012814 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595012815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595012816 Walker A/P-loop; other site 391595012817 ATP binding site [chemical binding]; other site 391595012818 Q-loop/lid; other site 391595012819 ABC transporter signature motif; other site 391595012820 Walker B; other site 391595012821 D-loop; other site 391595012822 H-loop/switch region; other site 391595012823 TOBE domain; Region: TOBE_2; pfam08402 391595012824 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 391595012825 active site 391595012826 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 391595012827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391595012828 putative substrate translocation pore; other site 391595012829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595012830 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 391595012831 putative effector binding pocket; other site 391595012832 putative dimerization interface [polypeptide binding]; other site 391595012833 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391595012834 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 391595012835 putative C-terminal domain interface [polypeptide binding]; other site 391595012836 putative GSH binding site (G-site) [chemical binding]; other site 391595012837 putative dimer interface [polypeptide binding]; other site 391595012838 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 391595012839 putative N-terminal domain interface [polypeptide binding]; other site 391595012840 putative dimer interface [polypeptide binding]; other site 391595012841 putative substrate binding pocket (H-site) [chemical binding]; other site 391595012842 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 391595012843 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 391595012844 FAD binding pocket [chemical binding]; other site 391595012845 FAD binding motif [chemical binding]; other site 391595012846 phosphate binding motif [ion binding]; other site 391595012847 beta-alpha-beta structure motif; other site 391595012848 NAD binding pocket [chemical binding]; other site 391595012849 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391595012850 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595012851 ligand binding site [chemical binding]; other site 391595012852 flexible hinge region; other site 391595012853 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595012854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391595012855 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391595012856 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391595012857 catalytic loop [active] 391595012858 iron binding site [ion binding]; other site 391595012859 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391595012860 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391595012861 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391595012862 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391595012863 short chain dehydrogenase; Provisional; Region: PRK06198 391595012864 classical (c) SDRs; Region: SDR_c; cd05233 391595012865 NAD(P) binding site [chemical binding]; other site 391595012866 active site 391595012867 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391595012868 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 391595012869 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 391595012870 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391595012871 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391595012872 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595012873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595012874 Walker A/P-loop; other site 391595012875 ATP binding site [chemical binding]; other site 391595012876 Q-loop/lid; other site 391595012877 ABC transporter signature motif; other site 391595012878 Walker B; other site 391595012879 D-loop; other site 391595012880 H-loop/switch region; other site 391595012881 TOBE domain; Region: TOBE_2; pfam08402 391595012882 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391595012883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595012884 Walker A/P-loop; other site 391595012885 ATP binding site [chemical binding]; other site 391595012886 Q-loop/lid; other site 391595012887 ABC transporter signature motif; other site 391595012888 Walker B; other site 391595012889 D-loop; other site 391595012890 H-loop/switch region; other site 391595012891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595012892 dimer interface [polypeptide binding]; other site 391595012893 conserved gate region; other site 391595012894 putative PBP binding loops; other site 391595012895 ABC-ATPase subunit interface; other site 391595012896 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391595012897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595012898 dimer interface [polypeptide binding]; other site 391595012899 conserved gate region; other site 391595012900 putative PBP binding loops; other site 391595012901 ABC-ATPase subunit interface; other site 391595012902 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391595012903 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391595012904 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391595012905 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 391595012906 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595012907 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595012908 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391595012909 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 391595012910 active site 391595012911 catalytic residues [active] 391595012912 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391595012913 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391595012914 DNA binding site [nucleotide binding] 391595012915 domain linker motif; other site 391595012916 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 391595012917 dimerization interface [polypeptide binding]; other site 391595012918 ligand binding site [chemical binding]; other site 391595012919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595012920 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391595012921 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595012922 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 391595012923 Helix-turn-helix domain; Region: HTH_18; pfam12833 391595012924 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391595012925 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391595012926 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391595012927 active site 391595012928 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 391595012929 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391595012930 Walker A motif; other site 391595012931 ATP binding site [chemical binding]; other site 391595012932 Walker B motif; other site 391595012933 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12627 391595012934 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12632 391595012935 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391595012936 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391595012937 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 391595012938 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 391595012939 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12690 391595012940 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391595012941 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 391595012942 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 391595012943 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391595012944 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391595012945 SAF-like; Region: SAF_2; pfam13144 391595012946 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 391595012947 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 391595012948 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 391595012949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391595012950 Transposase; Region: HTH_Tnp_1; cl17663 391595012951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391595012952 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391595012953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391595012954 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391595012955 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391595012956 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391595012957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391595012958 Transposase; Region: HTH_Tnp_1; cl17663 391595012959 Integrase core domain; Region: rve; pfam00665 391595012960 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391595012961 Integrase core domain; Region: rve_3; pfam13683 391595012962 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391595012963 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391595012964 catalytic residue [active] 391595012965 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 391595012966 FHIPEP family; Region: FHIPEP; pfam00771 391595012967 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 391595012968 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 391595012969 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 391595012970 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391595012971 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 391595012972 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 391595012973 Flagellar protein FlbT; Region: FlbT; pfam07378 391595012974 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794 391595012975 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 391595012976 FlgN protein; Region: FlgN; pfam05130 391595012977 Rod binding protein; Region: Rod-binding; pfam10135 391595012978 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 391595012979 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12813 391595012980 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 391595012981 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 391595012982 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391595012983 FAD dependent oxidoreductase; Region: DAO; pfam01266 391595012984 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595012985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595012986 dimer interface [polypeptide binding]; other site 391595012987 conserved gate region; other site 391595012988 putative PBP binding loops; other site 391595012989 ABC-ATPase subunit interface; other site 391595012990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595012991 dimer interface [polypeptide binding]; other site 391595012992 conserved gate region; other site 391595012993 putative PBP binding loops; other site 391595012994 ABC-ATPase subunit interface; other site 391595012995 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595012996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595012997 Walker A/P-loop; other site 391595012998 ATP binding site [chemical binding]; other site 391595012999 Q-loop/lid; other site 391595013000 ABC transporter signature motif; other site 391595013001 Walker B; other site 391595013002 D-loop; other site 391595013003 H-loop/switch region; other site 391595013004 TOBE domain; Region: TOBE_2; pfam08402 391595013005 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 391595013006 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391595013007 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391595013008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391595013009 DNA-binding site [nucleotide binding]; DNA binding site 391595013010 FCD domain; Region: FCD; pfam07729 391595013011 putative aminotransferase; Validated; Region: PRK07480 391595013012 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391595013013 inhibitor-cofactor binding pocket; inhibition site 391595013014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595013015 catalytic residue [active] 391595013016 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595013017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595013018 Walker A/P-loop; other site 391595013019 ATP binding site [chemical binding]; other site 391595013020 Q-loop/lid; other site 391595013021 ABC transporter signature motif; other site 391595013022 Walker B; other site 391595013023 D-loop; other site 391595013024 H-loop/switch region; other site 391595013025 TOBE domain; Region: TOBE_2; pfam08402 391595013026 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391595013027 Uncharacterized conserved protein [Function unknown]; Region: COG5470 391595013028 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 391595013029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595013030 dimer interface [polypeptide binding]; other site 391595013031 conserved gate region; other site 391595013032 putative PBP binding loops; other site 391595013033 ABC-ATPase subunit interface; other site 391595013034 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595013035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595013036 dimer interface [polypeptide binding]; other site 391595013037 conserved gate region; other site 391595013038 putative PBP binding loops; other site 391595013039 ABC-ATPase subunit interface; other site 391595013040 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391595013041 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391595013042 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391595013043 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391595013044 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391595013045 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391595013046 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 391595013047 putative N-terminal domain interface [polypeptide binding]; other site 391595013048 ribonuclease R; Region: RNase_R; TIGR02063 391595013049 RNB domain; Region: RNB; pfam00773 391595013050 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 391595013051 RNA binding site [nucleotide binding]; other site 391595013052 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 391595013053 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 391595013054 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 391595013055 metal binding site [ion binding]; metal-binding site 391595013056 dimer interface [polypeptide binding]; other site 391595013057 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 391595013058 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 391595013059 trimer interface [polypeptide binding]; other site 391595013060 active site 391595013061 substrate binding site [chemical binding]; other site 391595013062 CoA binding site [chemical binding]; other site 391595013063 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 391595013064 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391595013065 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 391595013066 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 391595013067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391595013068 FeS/SAM binding site; other site 391595013069 L-asparaginase II; Region: Asparaginase_II; pfam06089 391595013070 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 391595013071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391595013072 motif II; other site 391595013073 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391595013074 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391595013075 Integrase core domain; Region: rve; pfam00665 391595013076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391595013077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391595013078 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391595013079 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391595013080 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595013081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595013082 dimer interface [polypeptide binding]; other site 391595013083 ABC-ATPase subunit interface; other site 391595013084 putative PBP binding loops; other site 391595013085 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391595013086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391595013087 dimer interface [polypeptide binding]; other site 391595013088 conserved gate region; other site 391595013089 putative PBP binding loops; other site 391595013090 ABC-ATPase subunit interface; other site 391595013091 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391595013092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391595013093 Walker A/P-loop; other site 391595013094 ATP binding site [chemical binding]; other site 391595013095 Q-loop/lid; other site 391595013096 ABC transporter signature motif; other site 391595013097 Walker B; other site 391595013098 D-loop; other site 391595013099 H-loop/switch region; other site 391595013100 TOBE domain; Region: TOBE_2; pfam08402 391595013101 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391595013102 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391595013103 Transposase; Region: HTH_Tnp_1; cl17663 391595013104 Integrase core domain; Region: rve; pfam00665 391595013105 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391595013106 Integrase core domain; Region: rve_3; pfam13683 391595013107 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391595013108 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391595013109 Integrase core domain; Region: rve; pfam00665 391595013110 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 391595013111 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 391595013112 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 391595013113 putative trimer interface [polypeptide binding]; other site 391595013114 putative CoA binding site [chemical binding]; other site 391595013115 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391595013116 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595013117 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 391595013118 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 391595013119 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 391595013120 Substrate binding site; other site 391595013121 metal-binding site 391595013122 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 391595013123 ligand binding site; other site 391595013124 tetramer interface; other site 391595013125 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 391595013126 NeuB family; Region: NeuB; pfam03102 391595013127 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 391595013128 NeuB binding interface [polypeptide binding]; other site 391595013129 putative substrate binding site [chemical binding]; other site 391595013130 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 391595013131 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 391595013132 homodimer interface [polypeptide binding]; other site 391595013133 active site 391595013134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391595013135 NAD(P) binding site [chemical binding]; other site 391595013136 active site 391595013137 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 391595013138 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 391595013139 inhibitor-cofactor binding pocket; inhibition site 391595013140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595013141 catalytic residue [active] 391595013142 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391595013143 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 391595013144 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 391595013145 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 391595013146 NADP-binding site; other site 391595013147 homotetramer interface [polypeptide binding]; other site 391595013148 substrate binding site [chemical binding]; other site 391595013149 homodimer interface [polypeptide binding]; other site 391595013150 active site 391595013151 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 391595013152 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 391595013153 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391595013154 active site 391595013155 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 391595013156 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391595013157 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 391595013158 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 391595013159 putative active site [active] 391595013160 putative cosubstrate binding site; other site 391595013161 putative substrate binding site [chemical binding]; other site 391595013162 catalytic site [active] 391595013163 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 391595013164 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 391595013165 inhibitor-cofactor binding pocket; inhibition site 391595013166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595013167 catalytic residue [active] 391595013168 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391595013169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595013170 S-adenosylmethionine binding site [chemical binding]; other site 391595013171 Transposase; Region: HTH_Tnp_1; cl17663 391595013172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391595013173 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 391595013174 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 391595013175 active site 391595013176 homodimer interface [polypeptide binding]; other site 391595013177 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 391595013178 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 391595013179 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 391595013180 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 391595013181 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 391595013182 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 391595013183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391595013184 Integrase core domain; Region: rve; pfam00665 391595013185 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391595013186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391595013187 Helix-turn-helix domain; Region: HTH_36; pfam13730 391595013188 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 391595013189 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595013190 catalytic residue [active] 391595013191 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 391595013192 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 391595013193 ligand binding site [chemical binding]; other site 391595013194 NAD binding site [chemical binding]; other site 391595013195 dimerization interface [polypeptide binding]; other site 391595013196 catalytic site [active] 391595013197 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 391595013198 putative L-serine binding site [chemical binding]; other site 391595013199 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 391595013200 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391595013201 NAD(P) binding site [chemical binding]; other site 391595013202 2-amino-3-ketobutyrate coenzyme A ligase; Provisional; Region: PRK06939 391595013203 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 391595013204 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595013205 catalytic residue [active] 391595013206 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391595013207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391595013208 non-specific DNA binding site [nucleotide binding]; other site 391595013209 salt bridge; other site 391595013210 sequence-specific DNA binding site [nucleotide binding]; other site 391595013211 Cupin domain; Region: Cupin_2; cl17218 391595013212 beta-ketothiolase; Provisional; Region: PRK09051 391595013213 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391595013214 dimer interface [polypeptide binding]; other site 391595013215 active site 391595013216 ABC1 family; Region: ABC1; cl17513 391595013217 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 391595013218 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 391595013219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595013220 S-adenosylmethionine binding site [chemical binding]; other site 391595013221 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 391595013222 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 391595013223 DNA binding site [nucleotide binding] 391595013224 catalytic residue [active] 391595013225 H2TH interface [polypeptide binding]; other site 391595013226 putative catalytic residues [active] 391595013227 turnover-facilitating residue; other site 391595013228 intercalation triad [nucleotide binding]; other site 391595013229 8OG recognition residue [nucleotide binding]; other site 391595013230 putative reading head residues; other site 391595013231 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 391595013232 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 391595013233 enoyl-CoA hydratase; Provisional; Region: PRK05862 391595013234 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391595013235 substrate binding site [chemical binding]; other site 391595013236 oxyanion hole (OAH) forming residues; other site 391595013237 trimer interface [polypeptide binding]; other site 391595013238 META domain; Region: META; pfam03724 391595013239 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 391595013240 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 391595013241 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391595013242 P-loop; other site 391595013243 Magnesium ion binding site [ion binding]; other site 391595013244 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391595013245 Magnesium ion binding site [ion binding]; other site 391595013246 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 391595013247 ParB-like nuclease domain; Region: ParB; smart00470 391595013248 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 391595013249 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 391595013250 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 391595013251 metal ion-dependent adhesion site (MIDAS); other site 391595013252 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 391595013253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391595013254 Walker A motif; other site 391595013255 ATP binding site [chemical binding]; other site 391595013256 Walker B motif; other site 391595013257 arginine finger; other site 391595013258 phytoene desaturase; Region: crtI_fam; TIGR02734 391595013259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595013260 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 391595013261 active site lid residues [active] 391595013262 substrate binding pocket [chemical binding]; other site 391595013263 catalytic residues [active] 391595013264 substrate-Mg2+ binding site; other site 391595013265 aspartate-rich region 1; other site 391595013266 aspartate-rich region 2; other site 391595013267 TspO/MBR family; Region: TspO_MBR; pfam03073 391595013268 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 391595013269 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 391595013270 phytoene desaturase; Region: crtI_fam; TIGR02734 391595013271 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391595013272 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 391595013273 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391595013274 substrate binding pocket [chemical binding]; other site 391595013275 chain length determination region; other site 391595013276 substrate-Mg2+ binding site; other site 391595013277 catalytic residues [active] 391595013278 aspartate-rich region 1; other site 391595013279 active site lid residues [active] 391595013280 aspartate-rich region 2; other site 391595013281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595013282 S-adenosylmethionine binding site [chemical binding]; other site 391595013283 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 391595013284 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 391595013285 putative NAD(P) binding site [chemical binding]; other site 391595013286 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391595013287 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 391595013288 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 391595013289 Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980 391595013290 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 391595013291 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 391595013292 PufQ cytochrome subunit; Region: PufQ; pfam05398 391595013293 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 391595013294 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 391595013295 subunit M interface; other site 391595013296 subunit H interface; other site 391595013297 quinone binding site; other site 391595013298 bacteriopheophytin binding site; other site 391595013299 bacteriochlorophyll binding site; other site 391595013300 cytochrome C subunit interface; other site 391595013301 Fe binding site [ion binding]; other site 391595013302 photosynthetic reaction center subunit M; Provisional; Region: PRK14504 391595013303 pheophytin binding site; other site 391595013304 chlorophyll binding site; other site 391595013305 quinone binding site; other site 391595013306 Fe binding site [ion binding]; other site 391595013307 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224 391595013308 subunit interface [polypeptide binding]; other site 391595013309 Heme binding sites [chemical binding]; other site 391595013310 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 391595013311 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 391595013312 TPP-binding site; other site 391595013313 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391595013314 PYR/PP interface [polypeptide binding]; other site 391595013315 dimer interface [polypeptide binding]; other site 391595013316 TPP binding site [chemical binding]; other site 391595013317 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391595013318 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 391595013319 putative active site pocket [active] 391595013320 cleavage site 391595013321 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 391595013322 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 391595013323 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 391595013324 putative NAD(P) binding site [chemical binding]; other site 391595013325 active site 391595013326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391595013327 Coenzyme A binding pocket [chemical binding]; other site 391595013328 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 391595013329 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 391595013330 active site 391595013331 metal binding site [ion binding]; metal-binding site 391595013332 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 391595013333 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 391595013334 active site 391595013335 oligomerization interface [polypeptide binding]; other site 391595013336 metal binding site [ion binding]; metal-binding site 391595013337 Pantoate-beta-alanine ligase; Region: PanC; cd00560 391595013338 pantoate--beta-alanine ligase; Region: panC; TIGR00018 391595013339 active site 391595013340 ATP-binding site [chemical binding]; other site 391595013341 pantoate-binding site; other site 391595013342 HXXH motif; other site 391595013343 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13013 391595013344 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 391595013345 metal binding site [ion binding]; metal-binding site 391595013346 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391595013347 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391595013348 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391595013349 catalytic residue [active] 391595013350 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 391595013351 two-component response regulator; Provisional; Region: PRK09191 391595013352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 391595013353 DNA binding residues [nucleotide binding] 391595013354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391595013355 active site 391595013356 phosphorylation site [posttranslational modification] 391595013357 intermolecular recognition site; other site 391595013358 dimerization interface [polypeptide binding]; other site 391595013359 RNA polymerase sigma factor; Provisional; Region: PRK12546 391595013360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391595013361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391595013362 DNA binding residues [nucleotide binding] 391595013363 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 391595013364 Histidine kinase; Region: HisKA_2; pfam07568 391595013365 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 391595013366 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 391595013367 active site 391595013368 FMN binding site [chemical binding]; other site 391595013369 substrate binding site [chemical binding]; other site 391595013370 3Fe-4S cluster binding site [ion binding]; other site 391595013371 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391595013372 Protein of unknown function (DUF330); Region: DUF330; pfam03886 391595013373 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 391595013374 mce related protein; Region: MCE; pfam02470 391595013375 Paraquat-inducible protein A; Region: PqiA; pfam04403 391595013376 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 391595013377 Paraquat-inducible protein A; Region: PqiA; pfam04403 391595013378 D-lactate dehydrogenase; Provisional; Region: PRK11183 391595013379 FAD binding domain; Region: FAD_binding_4; pfam01565 391595013380 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 391595013381 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 391595013382 Cysteine-rich domain; Region: CCG; pfam02754 391595013383 Cysteine-rich domain; Region: CCG; pfam02754 391595013384 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 391595013385 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 391595013386 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391595013387 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 391595013388 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 391595013389 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 391595013390 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391595013391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391595013392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391595013393 dimerization interface [polypeptide binding]; other site 391595013394 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 391595013395 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391595013396 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 391595013397 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391595013398 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391595013399 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391595013400 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391595013401 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 391595013402 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391595013403 Sulfatase; Region: Sulfatase; pfam00884 391595013404 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 391595013405 Uncharacterized conserved protein [Function unknown]; Region: COG5361 391595013406 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 391595013407 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 391595013408 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391595013409 Sulfatase; Region: Sulfatase; pfam00884 391595013410 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391595013411 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391595013412 ligand binding site [chemical binding]; other site 391595013413 flexible hinge region; other site 391595013414 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 391595013415 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 391595013416 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 391595013417 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 391595013418 nudix motif; other site 391595013419 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 391595013420 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 391595013421 PUCC protein; Region: PUCC; pfam03209 391595013422 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 391595013423 UbiA prenyltransferase family; Region: UbiA; pfam01040 391595013424 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 391595013425 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391595013426 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 391595013427 B12 binding site [chemical binding]; other site 391595013428 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 391595013429 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 391595013430 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 391595013431 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 391595013432 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 391595013433 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 391595013434 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 391595013435 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 391595013436 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 391595013437 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 391595013438 P-loop; other site 391595013439 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 391595013440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391595013441 S-adenosylmethionine binding site [chemical binding]; other site 391595013442 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 391595013443 PUCC protein; Region: PUCC; pfam03209 391595013444 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cd00226 391595013445 subunit C interaction residues; other site 391595013446 photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150 391595013447 subunit M interaction residues [polypeptide binding]; other site 391595013448 subunit L interaction residues [polypeptide binding]; other site 391595013449 putative proton transfer pathway, P1; other site 391595013450 putative proton transfer pathway, P2; other site 391595013451 Bacterial PH domain; Region: DUF304; pfam03703 391595013452 putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054 391595013453 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 391595013454 diiron binding motif [ion binding]; other site 391595013455 Protein of unknown function (DUF3623); Region: DUF3623; pfam12291 391595013456 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 391595013457 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 391595013458 substrate-cofactor binding pocket; other site 391595013459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391595013460 catalytic residue [active] 391595013461 Cytochrome c; Region: Cytochrom_C; cl11414 391595013462 DnaA N-terminal domain; Region: DnaA_N; pfam11638