-- dump date 20140620_041054 -- class Genbank::misc_feature -- table misc_feature_note -- id note 762948000001 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 762948000002 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 762948000003 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762948000004 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 762948000005 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762948000006 DNA binding residues [nucleotide binding] 762948000007 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 762948000008 PAC2 family; Region: PAC2; pfam09754 762948000009 multifunctional aminopeptidase A; Provisional; Region: PRK00913 762948000010 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 762948000011 interface (dimer of trimers) [polypeptide binding]; other site 762948000012 Substrate-binding/catalytic site; other site 762948000013 Zn-binding sites [ion binding]; other site 762948000014 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 762948000015 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762948000016 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762948000017 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 762948000018 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762948000019 E3 interaction surface; other site 762948000020 lipoyl attachment site [posttranslational modification]; other site 762948000021 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762948000022 E3 interaction surface; other site 762948000023 lipoyl attachment site [posttranslational modification]; other site 762948000024 e3 binding domain; Region: E3_binding; pfam02817 762948000025 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 762948000026 lipoate-protein ligase B; Provisional; Region: PRK14345 762948000027 lipoyl synthase; Provisional; Region: PRK05481 762948000028 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762948000029 FeS/SAM binding site; other site 762948000030 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 762948000031 RDD family; Region: RDD; pfam06271 762948000032 glutamine synthetase, type I; Region: GlnA; TIGR00653 762948000033 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 762948000034 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 762948000035 SnoaL-like domain; Region: SnoaL_4; cl17707 762948000036 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 762948000037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762948000038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762948000039 Coenzyme A binding pocket [chemical binding]; other site 762948000040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762948000041 Coenzyme A binding pocket [chemical binding]; other site 762948000042 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 762948000043 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 762948000044 nucleotide binding site/active site [active] 762948000045 HIT family signature motif; other site 762948000046 catalytic residue [active] 762948000047 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 762948000048 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762948000049 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762948000050 metal binding site 2 [ion binding]; metal-binding site 762948000051 putative DNA binding helix; other site 762948000052 metal binding site 1 [ion binding]; metal-binding site 762948000053 dimer interface [polypeptide binding]; other site 762948000054 structural Zn2+ binding site [ion binding]; other site 762948000055 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 762948000056 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 762948000057 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 762948000058 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 762948000059 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 762948000060 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 762948000061 intersubunit interface [polypeptide binding]; other site 762948000062 Domain of unknown function DUF21; Region: DUF21; pfam01595 762948000063 FOG: CBS domain [General function prediction only]; Region: COG0517 762948000064 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762948000065 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 762948000066 Domain of unknown function DUF21; Region: DUF21; pfam01595 762948000067 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762948000068 Transporter associated domain; Region: CorC_HlyC; smart01091 762948000069 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 762948000070 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 762948000071 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 762948000072 TPP-binding site [chemical binding]; other site 762948000073 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 762948000074 PYR/PP interface [polypeptide binding]; other site 762948000075 dimer interface [polypeptide binding]; other site 762948000076 TPP binding site [chemical binding]; other site 762948000077 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 762948000078 active site 762948000079 catalytic triad [active] 762948000080 oxyanion hole [active] 762948000081 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 762948000082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762948000083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762948000084 DNA binding residues [nucleotide binding] 762948000085 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 762948000086 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 762948000087 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 762948000088 hinge; other site 762948000089 active site 762948000090 Predicted GTPases [General function prediction only]; Region: COG1162 762948000091 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 762948000092 GTPase/Zn-binding domain interface [polypeptide binding]; other site 762948000093 GTP/Mg2+ binding site [chemical binding]; other site 762948000094 G4 box; other site 762948000095 G5 box; other site 762948000096 G1 box; other site 762948000097 Switch I region; other site 762948000098 G2 box; other site 762948000099 G3 box; other site 762948000100 Switch II region; other site 762948000101 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 762948000102 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 762948000103 active site 762948000104 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 762948000105 SmpB-tmRNA interface; other site 762948000106 peptide chain release factor 2; Validated; Region: prfB; PRK00578 762948000107 This domain is found in peptide chain release factors; Region: PCRF; smart00937 762948000108 RF-1 domain; Region: RF-1; pfam00472 762948000109 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 762948000110 TadE-like protein; Region: TadE; pfam07811 762948000111 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 762948000112 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 762948000113 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 762948000114 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 762948000115 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 762948000116 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 762948000117 ATP binding site [chemical binding]; other site 762948000118 Walker A motif; other site 762948000119 hexamer interface [polypeptide binding]; other site 762948000120 Walker B motif; other site 762948000121 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 762948000122 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 762948000123 Walker A/P-loop; other site 762948000124 ATP binding site [chemical binding]; other site 762948000125 Q-loop/lid; other site 762948000126 ABC transporter signature motif; other site 762948000127 Walker B; other site 762948000128 D-loop; other site 762948000129 H-loop/switch region; other site 762948000130 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 762948000131 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 762948000132 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 762948000133 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762948000134 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 762948000135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762948000136 UDP-galactopyranose mutase; Region: GLF; pfam03275 762948000137 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 762948000138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 762948000139 Transcription factor WhiB; Region: Whib; pfam02467 762948000140 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 762948000141 PAS fold; Region: PAS_4; pfam08448 762948000142 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 762948000143 Histidine kinase; Region: HisKA_2; pfam07568 762948000144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762948000145 ATP binding site [chemical binding]; other site 762948000146 Mg2+ binding site [ion binding]; other site 762948000147 G-X-G motif; other site 762948000148 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 762948000149 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 762948000150 Helix-turn-helix domain; Region: HTH_17; pfam12728 762948000151 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762948000152 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 762948000153 DEAD/DEAH box helicase; Region: DEAD; pfam00270 762948000154 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 762948000155 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 762948000156 nucleotide binding region [chemical binding]; other site 762948000157 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 762948000158 30S subunit binding site; other site 762948000159 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 762948000160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762948000161 active site 762948000162 lipoprotein LpqB; Provisional; Region: PRK13614 762948000163 Sporulation and spore germination; Region: Germane; pfam10646 762948000164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762948000165 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762948000166 dimerization interface [polypeptide binding]; other site 762948000167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762948000168 dimer interface [polypeptide binding]; other site 762948000169 phosphorylation site [posttranslational modification] 762948000170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762948000171 ATP binding site [chemical binding]; other site 762948000172 Mg2+ binding site [ion binding]; other site 762948000173 G-X-G motif; other site 762948000174 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762948000175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762948000176 active site 762948000177 phosphorylation site [posttranslational modification] 762948000178 intermolecular recognition site; other site 762948000179 dimerization interface [polypeptide binding]; other site 762948000180 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762948000181 DNA binding site [nucleotide binding] 762948000182 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 762948000183 chorismate mutase; Provisional; Region: PRK09239 762948000184 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 762948000185 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 762948000186 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 762948000187 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762948000188 catalytic residue [active] 762948000189 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 762948000190 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 762948000191 putative uracil binding site [chemical binding]; other site 762948000192 putative active site [active] 762948000193 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 762948000194 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 762948000195 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 762948000196 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 762948000197 Ligand binding site [chemical binding]; other site 762948000198 Electron transfer flavoprotein domain; Region: ETF; pfam01012 762948000199 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 762948000200 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 762948000201 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762948000202 protein binding site [polypeptide binding]; other site 762948000203 Repair protein; Region: Repair_PSII; pfam04536 762948000204 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 762948000205 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 762948000206 S-layer homology domain; Region: SLH; pfam00395 762948000207 S-layer homology domain; Region: SLH; pfam00395 762948000208 S-layer homology domain; Region: SLH; pfam00395 762948000209 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762948000210 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762948000211 active site 762948000212 catalytic tetrad [active] 762948000213 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 762948000214 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 762948000215 Uncharacterized conserved protein [Function unknown]; Region: COG1615 762948000216 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 762948000217 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 762948000218 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 762948000219 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 762948000220 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 762948000221 Protein of unknown function DUF45; Region: DUF45; cl00636 762948000222 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 762948000223 Part of AAA domain; Region: AAA_19; pfam13245 762948000224 Family description; Region: UvrD_C_2; pfam13538 762948000225 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 762948000226 active site 762948000227 ATP binding site [chemical binding]; other site 762948000228 Phosphotransferase enzyme family; Region: APH; pfam01636 762948000229 substrate binding site [chemical binding]; other site 762948000230 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 762948000231 Part of AAA domain; Region: AAA_19; pfam13245 762948000232 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 762948000233 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 762948000234 Part of AAA domain; Region: AAA_19; pfam13245 762948000235 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 762948000236 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 762948000237 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 762948000238 active site 762948000239 catalytic site [active] 762948000240 substrate binding site [chemical binding]; other site 762948000241 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 762948000242 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 762948000243 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762948000244 MarR family; Region: MarR; pfam01047 762948000245 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 762948000246 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762948000247 active site 762948000248 hypothetical protein; Provisional; Region: PRK02268 762948000249 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 762948000250 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762948000251 inhibitor-cofactor binding pocket; inhibition site 762948000252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948000253 catalytic residue [active] 762948000254 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 762948000255 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 762948000256 dimer interface [polypeptide binding]; other site 762948000257 active site 762948000258 Schiff base residues; other site 762948000259 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 762948000260 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 762948000261 active site 762948000262 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 762948000263 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 762948000264 domain interfaces; other site 762948000265 active site 762948000266 ferrochelatase; Reviewed; Region: hemH; PRK00035 762948000267 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 762948000268 C-terminal domain interface [polypeptide binding]; other site 762948000269 active site 762948000270 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 762948000271 active site 762948000272 N-terminal domain interface [polypeptide binding]; other site 762948000273 Chlorite dismutase; Region: Chlor_dismutase; cl01280 762948000274 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 762948000275 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762948000276 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 762948000277 substrate binding site [chemical binding]; other site 762948000278 active site 762948000279 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 762948000280 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 762948000281 NAD(P) binding pocket [chemical binding]; other site 762948000282 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 762948000283 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 762948000284 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 762948000285 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762948000286 ATP binding site [chemical binding]; other site 762948000287 Mg++ binding site [ion binding]; other site 762948000288 motif III; other site 762948000289 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762948000290 nucleotide binding region [chemical binding]; other site 762948000291 ATP-binding site [chemical binding]; other site 762948000292 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 762948000293 DNA methylase; Region: N6_N4_Mtase; pfam01555 762948000294 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 762948000295 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 762948000296 active site 762948000297 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 762948000298 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 762948000299 proline aminopeptidase P II; Provisional; Region: PRK10879 762948000300 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 762948000301 active site 762948000302 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 762948000303 MgtE intracellular N domain; Region: MgtE_N; smart00924 762948000304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 762948000305 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 762948000306 Domain of unknown function DUF59; Region: DUF59; cl00941 762948000307 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 762948000308 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 762948000309 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 762948000310 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 762948000311 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 762948000312 metal binding site [ion binding]; metal-binding site 762948000313 putative dimer interface [polypeptide binding]; other site 762948000314 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 762948000315 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 762948000316 putative trimer interface [polypeptide binding]; other site 762948000317 putative CoA binding site [chemical binding]; other site 762948000318 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 762948000319 UDP-glucose 4-epimerase; Region: PLN02240 762948000320 NAD binding site [chemical binding]; other site 762948000321 homodimer interface [polypeptide binding]; other site 762948000322 active site 762948000323 substrate binding site [chemical binding]; other site 762948000324 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762948000325 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762948000326 Walker A/P-loop; other site 762948000327 ATP binding site [chemical binding]; other site 762948000328 Q-loop/lid; other site 762948000329 ABC transporter signature motif; other site 762948000330 Walker B; other site 762948000331 D-loop; other site 762948000332 H-loop/switch region; other site 762948000333 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762948000334 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762948000335 substrate binding pocket [chemical binding]; other site 762948000336 membrane-bound complex binding site; other site 762948000337 hinge residues; other site 762948000338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762948000339 dimer interface [polypeptide binding]; other site 762948000340 conserved gate region; other site 762948000341 ABC-ATPase subunit interface; other site 762948000342 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762948000343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762948000344 dimer interface [polypeptide binding]; other site 762948000345 conserved gate region; other site 762948000346 putative PBP binding loops; other site 762948000347 ABC-ATPase subunit interface; other site 762948000348 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 762948000349 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762948000350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948000351 homodimer interface [polypeptide binding]; other site 762948000352 catalytic residue [active] 762948000353 Ferredoxin [Energy production and conversion]; Region: COG1146 762948000354 4Fe-4S binding domain; Region: Fer4; pfam00037 762948000355 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 762948000356 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 762948000357 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 762948000358 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 762948000359 G1 box; other site 762948000360 putative GEF interaction site [polypeptide binding]; other site 762948000361 GTP/Mg2+ binding site [chemical binding]; other site 762948000362 Switch I region; other site 762948000363 G2 box; other site 762948000364 G3 box; other site 762948000365 Switch II region; other site 762948000366 G4 box; other site 762948000367 G5 box; other site 762948000368 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 762948000369 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 762948000370 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 762948000371 putative NADH binding site [chemical binding]; other site 762948000372 putative active site [active] 762948000373 nudix motif; other site 762948000374 putative metal binding site [ion binding]; other site 762948000375 potential frameshift: common BLAST hit: gi|283458736|ref|YP_003363374.1| predicted acyltransferase 762948000376 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 762948000377 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 762948000378 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 762948000379 active site 762948000380 dimer interface [polypeptide binding]; other site 762948000381 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 762948000382 dimer interface [polypeptide binding]; other site 762948000383 active site 762948000384 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 762948000385 putative substrate binding pocket [chemical binding]; other site 762948000386 AC domain interface; other site 762948000387 catalytic triad [active] 762948000388 AB domain interface; other site 762948000389 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 762948000390 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 762948000391 nudix motif; other site 762948000392 Uncharacterized conserved protein [Function unknown]; Region: COG3189 762948000393 lysine transporter; Provisional; Region: PRK10836 762948000394 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 762948000395 active site pocket [active] 762948000396 oxyanion hole [active] 762948000397 catalytic triad [active] 762948000398 active site nucleophile [active] 762948000399 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762948000400 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 762948000401 OsmC-like protein; Region: OsmC; pfam02566 762948000402 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 762948000403 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 762948000404 AzlC protein; Region: AzlC; cl00570 762948000405 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 762948000406 dimer interface [polypeptide binding]; other site 762948000407 catalytic triad [active] 762948000408 peroxidatic and resolving cysteines [active] 762948000409 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 762948000410 Predicted membrane protein [Function unknown]; Region: COG4270 762948000411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948000412 S-adenosylmethionine binding site [chemical binding]; other site 762948000413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948000414 S-adenosylmethionine binding site [chemical binding]; other site 762948000415 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 762948000416 catalytic triad [active] 762948000417 active site nucleophile [active] 762948000418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948000419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948000420 SnoaL-like domain; Region: SnoaL_2; pfam12680 762948000421 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 762948000422 classical (c) SDRs; Region: SDR_c; cd05233 762948000423 NAD(P) binding site [chemical binding]; other site 762948000424 active site 762948000425 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 762948000426 conserved cys residue [active] 762948000427 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762948000428 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 762948000429 putative NAD(P) binding site [chemical binding]; other site 762948000430 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 762948000431 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 762948000432 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 762948000433 putative active site [active] 762948000434 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 762948000435 Methyltransferase domain; Region: Methyltransf_11; pfam08241 762948000436 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 762948000437 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 762948000438 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 762948000439 potential frameshift: common BLAST hit: gi|119866087|ref|YP_936039.1| N-6 DNA methylase 762948000440 GTP-binding protein YchF; Reviewed; Region: PRK09601 762948000441 YchF GTPase; Region: YchF; cd01900 762948000442 G1 box; other site 762948000443 GTP/Mg2+ binding site [chemical binding]; other site 762948000444 Switch I region; other site 762948000445 G2 box; other site 762948000446 Switch II region; other site 762948000447 G3 box; other site 762948000448 G4 box; other site 762948000449 G5 box; other site 762948000450 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 762948000451 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762948000452 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762948000453 Walker A/P-loop; other site 762948000454 ATP binding site [chemical binding]; other site 762948000455 Q-loop/lid; other site 762948000456 ABC transporter signature motif; other site 762948000457 Walker B; other site 762948000458 D-loop; other site 762948000459 H-loop/switch region; other site 762948000460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 762948000461 Histidine kinase; Region: HisKA_3; pfam07730 762948000462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762948000463 ATP binding site [chemical binding]; other site 762948000464 Mg2+ binding site [ion binding]; other site 762948000465 G-X-G motif; other site 762948000466 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762948000467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762948000468 active site 762948000469 phosphorylation site [posttranslational modification] 762948000470 intermolecular recognition site; other site 762948000471 dimerization interface [polypeptide binding]; other site 762948000472 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762948000473 DNA binding residues [nucleotide binding] 762948000474 dimerization interface [polypeptide binding]; other site 762948000475 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 762948000476 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 762948000477 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 762948000478 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 762948000479 generic binding surface II; other site 762948000480 generic binding surface I; other site 762948000481 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 762948000482 aminotransferase AlaT; Validated; Region: PRK09265 762948000483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762948000484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948000485 homodimer interface [polypeptide binding]; other site 762948000486 catalytic residue [active] 762948000487 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 762948000488 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 762948000489 nudix motif; other site 762948000490 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762948000491 dimerization interface [polypeptide binding]; other site 762948000492 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 762948000493 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 762948000494 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 762948000495 active site 762948000496 tetramer interface; other site 762948000497 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 762948000498 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 762948000499 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 762948000500 Part of AAA domain; Region: AAA_19; pfam13245 762948000501 AAA domain; Region: AAA_12; pfam13087 762948000502 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762948000503 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 762948000504 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 762948000505 putative active site [active] 762948000506 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 762948000507 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 762948000508 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 762948000509 active site turn [active] 762948000510 phosphorylation site [posttranslational modification] 762948000511 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 762948000512 putative catalytic site [active] 762948000513 putative metal binding site [ion binding]; other site 762948000514 putative phosphate binding site [ion binding]; other site 762948000515 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762948000516 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 762948000517 Ca binding site [ion binding]; other site 762948000518 active site 762948000519 catalytic site [active] 762948000520 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762948000521 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 762948000522 Ca binding site [ion binding]; other site 762948000523 active site 762948000524 catalytic site [active] 762948000525 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762948000526 Phospholipid methyltransferase; Region: PEMT; pfam04191 762948000527 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 762948000528 aspartate racemase; Region: asp_race; TIGR00035 762948000529 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 762948000530 dimer interface [polypeptide binding]; other site 762948000531 FMN binding site [chemical binding]; other site 762948000532 Predicted transcriptional regulators [Transcription]; Region: COG1733 762948000533 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762948000534 short chain dehydrogenase; Provisional; Region: PRK06500 762948000535 classical (c) SDRs; Region: SDR_c; cd05233 762948000536 NAD(P) binding site [chemical binding]; other site 762948000537 active site 762948000538 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762948000539 MarR family; Region: MarR_2; pfam12802 762948000540 GMP synthase; Reviewed; Region: guaA; PRK00074 762948000541 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 762948000542 AMP/PPi binding site [chemical binding]; other site 762948000543 candidate oxyanion hole; other site 762948000544 catalytic triad [active] 762948000545 potential glutamine specificity residues [chemical binding]; other site 762948000546 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 762948000547 ATP Binding subdomain [chemical binding]; other site 762948000548 Ligand Binding sites [chemical binding]; other site 762948000549 Dimerization subdomain; other site 762948000550 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 762948000551 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 762948000552 Domain of unknown function (DUF305); Region: DUF305; pfam03713 762948000553 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 762948000554 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762948000555 Soluble P-type ATPase [General function prediction only]; Region: COG4087 762948000556 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 762948000557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762948000558 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762948000559 dimerization interface [polypeptide binding]; other site 762948000560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762948000561 dimer interface [polypeptide binding]; other site 762948000562 phosphorylation site [posttranslational modification] 762948000563 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762948000564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762948000565 DNA binding site [nucleotide binding] 762948000566 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 762948000567 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 762948000568 phosphate binding site [ion binding]; other site 762948000569 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 762948000570 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 762948000571 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 762948000572 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 762948000573 active site 762948000574 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 762948000575 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 762948000576 ring oligomerisation interface [polypeptide binding]; other site 762948000577 ATP/Mg binding site [chemical binding]; other site 762948000578 stacking interactions; other site 762948000579 hinge regions; other site 762948000580 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 762948000581 oligomerisation interface [polypeptide binding]; other site 762948000582 mobile loop; other site 762948000583 roof hairpin; other site 762948000584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948000585 S-adenosylmethionine binding site [chemical binding]; other site 762948000586 carboxylate-amine ligase; Provisional; Region: PRK13517 762948000587 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 762948000588 UGMP family protein; Validated; Region: PRK09604 762948000589 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 762948000590 Fumble; Region: Fumble; cl17357 762948000591 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 762948000592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762948000593 Coenzyme A binding pocket [chemical binding]; other site 762948000594 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 762948000595 Glycoprotease family; Region: Peptidase_M22; pfam00814 762948000596 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 762948000597 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 762948000598 alanine racemase; Reviewed; Region: alr; PRK00053 762948000599 active site 762948000600 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762948000601 dimer interface [polypeptide binding]; other site 762948000602 substrate binding site [chemical binding]; other site 762948000603 catalytic residues [active] 762948000604 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 762948000605 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 762948000606 putative ADP-binding pocket [chemical binding]; other site 762948000607 potential frameshift: common BLAST hit: gi|283457590|ref|YP_003362174.1| sugar transferase 762948000608 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 762948000609 Bacterial sugar transferase; Region: Bac_transf; pfam02397 762948000610 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 762948000611 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 762948000612 putative substrate binding site [chemical binding]; other site 762948000613 putative ATP binding site [chemical binding]; other site 762948000614 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 762948000615 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 762948000616 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 762948000617 glutaminase active site [active] 762948000618 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 762948000619 dimer interface [polypeptide binding]; other site 762948000620 active site 762948000621 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 762948000622 dimer interface [polypeptide binding]; other site 762948000623 active site 762948000624 pantothenate kinase; Provisional; Region: PRK05439 762948000625 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 762948000626 ATP-binding site [chemical binding]; other site 762948000627 CoA-binding site [chemical binding]; other site 762948000628 Mg2+-binding site [ion binding]; other site 762948000629 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 762948000630 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 762948000631 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 762948000632 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 762948000633 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 762948000634 active site 762948000635 substrate binding site [chemical binding]; other site 762948000636 metal binding site [ion binding]; metal-binding site 762948000637 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 762948000638 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 762948000639 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 762948000640 23S rRNA interface [nucleotide binding]; other site 762948000641 L3 interface [polypeptide binding]; other site 762948000642 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 762948000643 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 762948000644 dimerization interface 3.5A [polypeptide binding]; other site 762948000645 active site 762948000646 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 762948000647 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 762948000648 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 762948000649 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 762948000650 alphaNTD - beta interaction site [polypeptide binding]; other site 762948000651 alphaNTD homodimer interface [polypeptide binding]; other site 762948000652 alphaNTD - beta' interaction site [polypeptide binding]; other site 762948000653 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 762948000654 30S ribosomal protein S11; Validated; Region: PRK05309 762948000655 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 762948000656 30S ribosomal protein S13; Region: bact_S13; TIGR03631 762948000657 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 762948000658 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 762948000659 rRNA binding site [nucleotide binding]; other site 762948000660 predicted 30S ribosome binding site; other site 762948000661 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 762948000662 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762948000663 FeS/SAM binding site; other site 762948000664 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 762948000665 active site 762948000666 adenylate kinase; Reviewed; Region: adk; PRK00279 762948000667 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 762948000668 AMP-binding site [chemical binding]; other site 762948000669 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 762948000670 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 762948000671 SecY translocase; Region: SecY; pfam00344 762948000672 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 762948000673 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 762948000674 23S rRNA binding site [nucleotide binding]; other site 762948000675 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 762948000676 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 762948000677 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 762948000678 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 762948000679 23S rRNA interface [nucleotide binding]; other site 762948000680 L21e interface [polypeptide binding]; other site 762948000681 5S rRNA interface [nucleotide binding]; other site 762948000682 L27 interface [polypeptide binding]; other site 762948000683 L5 interface [polypeptide binding]; other site 762948000684 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 762948000685 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762948000686 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762948000687 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 762948000688 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 762948000689 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 762948000690 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 762948000691 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 762948000692 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 762948000693 RNA binding site [nucleotide binding]; other site 762948000694 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 762948000695 Uncharacterized conserved protein [Function unknown]; Region: COG3391 762948000696 S-layer homology domain; Region: SLH; pfam00395 762948000697 S-layer homology domain; Region: SLH; pfam00395 762948000698 S-layer homology domain; Region: SLH; pfam00395 762948000699 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 762948000700 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 762948000701 putative translocon interaction site; other site 762948000702 23S rRNA interface [nucleotide binding]; other site 762948000703 signal recognition particle (SRP54) interaction site; other site 762948000704 L23 interface [polypeptide binding]; other site 762948000705 trigger factor interaction site; other site 762948000706 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 762948000707 23S rRNA interface [nucleotide binding]; other site 762948000708 5S rRNA interface [nucleotide binding]; other site 762948000709 putative antibiotic binding site [chemical binding]; other site 762948000710 L25 interface [polypeptide binding]; other site 762948000711 L27 interface [polypeptide binding]; other site 762948000712 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 762948000713 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 762948000714 G-X-X-G motif; other site 762948000715 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 762948000716 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 762948000717 putative translocon binding site; other site 762948000718 protein-rRNA interface [nucleotide binding]; other site 762948000719 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 762948000720 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 762948000721 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 762948000722 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 762948000723 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 762948000724 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 762948000725 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 762948000726 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 762948000727 YppG-like protein; Region: YppG; pfam14179 762948000728 elongation factor Tu; Reviewed; Region: PRK00049 762948000729 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 762948000730 G1 box; other site 762948000731 GEF interaction site [polypeptide binding]; other site 762948000732 GTP/Mg2+ binding site [chemical binding]; other site 762948000733 Switch I region; other site 762948000734 G2 box; other site 762948000735 G3 box; other site 762948000736 Switch II region; other site 762948000737 G4 box; other site 762948000738 G5 box; other site 762948000739 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 762948000740 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 762948000741 Antibiotic Binding Site [chemical binding]; other site 762948000742 elongation factor G; Reviewed; Region: PRK00007 762948000743 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 762948000744 G1 box; other site 762948000745 putative GEF interaction site [polypeptide binding]; other site 762948000746 GTP/Mg2+ binding site [chemical binding]; other site 762948000747 Switch I region; other site 762948000748 G2 box; other site 762948000749 G3 box; other site 762948000750 Switch II region; other site 762948000751 G4 box; other site 762948000752 G5 box; other site 762948000753 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 762948000754 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 762948000755 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 762948000756 30S ribosomal protein S7; Validated; Region: PRK05302 762948000757 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 762948000758 S17 interaction site [polypeptide binding]; other site 762948000759 S8 interaction site; other site 762948000760 16S rRNA interaction site [nucleotide binding]; other site 762948000761 streptomycin interaction site [chemical binding]; other site 762948000762 23S rRNA interaction site [nucleotide binding]; other site 762948000763 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 762948000764 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 762948000765 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 762948000766 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 762948000767 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 762948000768 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 762948000769 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 762948000770 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 762948000771 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 762948000772 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 762948000773 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 762948000774 G-loop; other site 762948000775 DNA binding site [nucleotide binding] 762948000776 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 762948000777 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 762948000778 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 762948000779 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 762948000780 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 762948000781 Peptidase family M23; Region: Peptidase_M23; pfam01551 762948000782 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 762948000783 RPB10 interaction site [polypeptide binding]; other site 762948000784 RPB1 interaction site [polypeptide binding]; other site 762948000785 RPB11 interaction site [polypeptide binding]; other site 762948000786 RPB3 interaction site [polypeptide binding]; other site 762948000787 RPB12 interaction site [polypeptide binding]; other site 762948000788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762948000789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762948000790 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762948000791 dimerization interface [polypeptide binding]; other site 762948000792 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762948000793 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762948000794 active site 762948000795 catalytic tetrad [active] 762948000796 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 762948000797 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 762948000798 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 762948000799 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 762948000800 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 762948000801 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 762948000802 glycine dehydrogenase; Provisional; Region: PRK05367 762948000803 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762948000804 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762948000805 catalytic residue [active] 762948000806 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 762948000807 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762948000808 catalytic residue [active] 762948000809 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 762948000810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948000811 putative substrate translocation pore; other site 762948000812 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 762948000813 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 762948000814 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 762948000815 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 762948000816 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 762948000817 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 762948000818 [4Fe-4S] binding site [ion binding]; other site 762948000819 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762948000820 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762948000821 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762948000822 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 762948000823 molybdopterin cofactor binding site; other site 762948000824 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 762948000825 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 762948000826 ATP binding site [chemical binding]; other site 762948000827 substrate interface [chemical binding]; other site 762948000828 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762948000829 active site residue [active] 762948000830 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 762948000831 MoaE homodimer interface [polypeptide binding]; other site 762948000832 MoaD interaction [polypeptide binding]; other site 762948000833 active site residues [active] 762948000834 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 762948000835 MPT binding site; other site 762948000836 trimer interface [polypeptide binding]; other site 762948000837 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 762948000838 trimer interface [polypeptide binding]; other site 762948000839 dimer interface [polypeptide binding]; other site 762948000840 putative active site [active] 762948000841 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 762948000842 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 762948000843 dimer interface [polypeptide binding]; other site 762948000844 putative functional site; other site 762948000845 putative MPT binding site; other site 762948000846 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 762948000847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762948000848 dimer interface [polypeptide binding]; other site 762948000849 conserved gate region; other site 762948000850 putative PBP binding loops; other site 762948000851 ABC-ATPase subunit interface; other site 762948000852 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 762948000853 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762948000854 substrate binding pocket [chemical binding]; other site 762948000855 membrane-bound complex binding site; other site 762948000856 hinge residues; other site 762948000857 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 762948000858 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762948000859 FeS/SAM binding site; other site 762948000860 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 762948000861 Ubiquitin-like proteins; Region: UBQ; cl00155 762948000862 charged pocket; other site 762948000863 hydrophobic patch; other site 762948000864 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 762948000865 GTP binding site; other site 762948000866 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 762948000867 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 762948000868 dimer interface [polypeptide binding]; other site 762948000869 putative functional site; other site 762948000870 putative MPT binding site; other site 762948000871 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762948000872 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762948000873 DNA binding site [nucleotide binding] 762948000874 domain linker motif; other site 762948000875 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 762948000876 dimerization interface [polypeptide binding]; other site 762948000877 ligand binding site [chemical binding]; other site 762948000878 sodium binding site [ion binding]; other site 762948000879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762948000880 Coenzyme A binding pocket [chemical binding]; other site 762948000881 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 762948000882 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 762948000883 active site turn [active] 762948000884 phosphorylation site [posttranslational modification] 762948000885 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 762948000886 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 762948000887 HPr interaction site; other site 762948000888 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762948000889 active site 762948000890 phosphorylation site [posttranslational modification] 762948000891 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 762948000892 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 762948000893 substrate binding [chemical binding]; other site 762948000894 active site 762948000895 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 762948000896 core dimer interface [polypeptide binding]; other site 762948000897 peripheral dimer interface [polypeptide binding]; other site 762948000898 L10 interface [polypeptide binding]; other site 762948000899 L11 interface [polypeptide binding]; other site 762948000900 putative EF-Tu interaction site [polypeptide binding]; other site 762948000901 putative EF-G interaction site [polypeptide binding]; other site 762948000902 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 762948000903 23S rRNA interface [nucleotide binding]; other site 762948000904 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 762948000905 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 762948000906 Walker A/P-loop; other site 762948000907 ATP binding site [chemical binding]; other site 762948000908 Q-loop/lid; other site 762948000909 ABC transporter signature motif; other site 762948000910 Walker B; other site 762948000911 D-loop; other site 762948000912 H-loop/switch region; other site 762948000913 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 762948000914 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 762948000915 gating phenylalanine in ion channel; other site 762948000916 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 762948000917 mRNA/rRNA interface [nucleotide binding]; other site 762948000918 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 762948000919 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 762948000920 23S rRNA interface [nucleotide binding]; other site 762948000921 L7/L12 interface [polypeptide binding]; other site 762948000922 putative thiostrepton binding site; other site 762948000923 L25 interface [polypeptide binding]; other site 762948000924 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 762948000925 amidase catalytic site [active] 762948000926 Zn binding residues [ion binding]; other site 762948000927 substrate binding site [chemical binding]; other site 762948000928 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 762948000929 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 762948000930 putative homodimer interface [polypeptide binding]; other site 762948000931 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 762948000932 heterodimer interface [polypeptide binding]; other site 762948000933 homodimer interface [polypeptide binding]; other site 762948000934 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 762948000935 aspartate aminotransferase; Provisional; Region: PRK05764 762948000936 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762948000937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948000938 homodimer interface [polypeptide binding]; other site 762948000939 catalytic residue [active] 762948000940 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 762948000941 phosphofructokinase; Region: PFK_mixed; TIGR02483 762948000942 active site 762948000943 ADP/pyrophosphate binding site [chemical binding]; other site 762948000944 dimerization interface [polypeptide binding]; other site 762948000945 allosteric effector site; other site 762948000946 fructose-1,6-bisphosphate binding site; other site 762948000947 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 762948000948 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 762948000949 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 762948000950 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 762948000951 heme-binding site [chemical binding]; other site 762948000952 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762948000953 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762948000954 DNA binding site [nucleotide binding] 762948000955 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 762948000956 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762948000957 polyphosphate kinase; Provisional; Region: PRK05443 762948000958 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 762948000959 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 762948000960 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 762948000961 putative domain interface [polypeptide binding]; other site 762948000962 putative active site [active] 762948000963 catalytic site [active] 762948000964 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 762948000965 putative domain interface [polypeptide binding]; other site 762948000966 putative active site [active] 762948000967 catalytic site [active] 762948000968 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 762948000969 active site 762948000970 Ap6A binding site [chemical binding]; other site 762948000971 nudix motif; other site 762948000972 metal binding site [ion binding]; metal-binding site 762948000973 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762948000974 catalytic core [active] 762948000975 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 762948000976 RHS Repeat; Region: RHS_repeat; pfam05593 762948000977 RHS Repeat; Region: RHS_repeat; pfam05593 762948000978 RHS Repeat; Region: RHS_repeat; pfam05593 762948000979 RHS Repeat; Region: RHS_repeat; cl11982 762948000980 RHS Repeat; Region: RHS_repeat; pfam05593 762948000981 RHS Repeat; Region: RHS_repeat; pfam05593 762948000982 RHS Repeat; Region: RHS_repeat; pfam05593 762948000983 RHS Repeat; Region: RHS_repeat; pfam05593 762948000984 RHS Repeat; Region: RHS_repeat; pfam05593 762948000985 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 762948000986 ribonuclease; Region: Ribonuclease; pfam00545 762948000987 active site 762948000988 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 762948000989 active site 762948000990 thymidylate synthase; Reviewed; Region: thyA; PRK01827 762948000991 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 762948000992 dimerization interface [polypeptide binding]; other site 762948000993 active site 762948000994 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 762948000995 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 762948000996 folate binding site [chemical binding]; other site 762948000997 NADP+ binding site [chemical binding]; other site 762948000998 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 762948000999 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 762948001000 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 762948001001 benzoate transport; Region: 2A0115; TIGR00895 762948001002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948001003 putative substrate translocation pore; other site 762948001004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948001005 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762948001006 MarR family; Region: MarR_2; pfam12802 762948001007 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 762948001008 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 762948001009 FAD binding domain; Region: FAD_binding_4; pfam01565 762948001010 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 762948001011 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 762948001012 active site 762948001013 catalytic site [active] 762948001014 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762948001015 active site 762948001016 catalytic site [active] 762948001017 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 762948001018 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 762948001019 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 762948001020 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 762948001021 ATP binding site [chemical binding]; other site 762948001022 Mg++ binding site [ion binding]; other site 762948001023 motif III; other site 762948001024 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762948001025 nucleotide binding region [chemical binding]; other site 762948001026 ATP-binding site [chemical binding]; other site 762948001027 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 762948001028 Predicted membrane protein [Function unknown]; Region: COG3463 762948001029 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 762948001030 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 762948001031 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 762948001032 helix-hairpin-helix signature motif; other site 762948001033 active site 762948001034 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762948001035 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762948001036 catalytic residues [active] 762948001037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 762948001038 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 762948001039 heat shock protein HtpX; Provisional; Region: PRK03072 762948001040 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762948001041 metal binding site 2 [ion binding]; metal-binding site 762948001042 putative DNA binding helix; other site 762948001043 metal binding site 1 [ion binding]; metal-binding site 762948001044 dimer interface [polypeptide binding]; other site 762948001045 structural Zn2+ binding site [ion binding]; other site 762948001046 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 762948001047 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 762948001048 tetramer interface [polypeptide binding]; other site 762948001049 heme binding pocket [chemical binding]; other site 762948001050 NADPH binding site [chemical binding]; other site 762948001051 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 762948001052 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762948001053 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762948001054 Walker A/P-loop; other site 762948001055 ATP binding site [chemical binding]; other site 762948001056 Q-loop/lid; other site 762948001057 ABC transporter signature motif; other site 762948001058 Walker B; other site 762948001059 D-loop; other site 762948001060 H-loop/switch region; other site 762948001061 Predicted permeases [General function prediction only]; Region: RarD; COG2962 762948001062 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 762948001063 EamA-like transporter family; Region: EamA; cl17759 762948001064 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 762948001065 Na2 binding site [ion binding]; other site 762948001066 putative substrate binding site 1 [chemical binding]; other site 762948001067 Na binding site 1 [ion binding]; other site 762948001068 putative substrate binding site 2 [chemical binding]; other site 762948001069 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 762948001070 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762948001071 substrate binding pocket [chemical binding]; other site 762948001072 chain length determination region; other site 762948001073 substrate-Mg2+ binding site; other site 762948001074 catalytic residues [active] 762948001075 aspartate-rich region 1; other site 762948001076 active site lid residues [active] 762948001077 aspartate-rich region 2; other site 762948001078 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 762948001079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948001080 S-adenosylmethionine binding site [chemical binding]; other site 762948001081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762948001082 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762948001083 substrate binding pocket [chemical binding]; other site 762948001084 membrane-bound complex binding site; other site 762948001085 hinge residues; other site 762948001086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762948001087 dimer interface [polypeptide binding]; other site 762948001088 conserved gate region; other site 762948001089 putative PBP binding loops; other site 762948001090 ABC-ATPase subunit interface; other site 762948001091 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762948001092 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762948001093 Walker A/P-loop; other site 762948001094 ATP binding site [chemical binding]; other site 762948001095 Q-loop/lid; other site 762948001096 ABC transporter signature motif; other site 762948001097 Walker B; other site 762948001098 D-loop; other site 762948001099 H-loop/switch region; other site 762948001100 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 762948001101 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 762948001102 active site 762948001103 O-succinylbenzoate synthase; Provisional; Region: PRK02901 762948001104 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 762948001105 active site 762948001106 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 762948001107 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 762948001108 dimer interface [polypeptide binding]; other site 762948001109 tetramer interface [polypeptide binding]; other site 762948001110 PYR/PP interface [polypeptide binding]; other site 762948001111 TPP binding site [chemical binding]; other site 762948001112 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 762948001113 TPP-binding site [chemical binding]; other site 762948001114 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762948001115 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 762948001116 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 762948001117 active site 762948001118 HIGH motif; other site 762948001119 nucleotide binding site [chemical binding]; other site 762948001120 active site 762948001121 KMSKS motif; other site 762948001122 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 762948001123 Na binding site [ion binding]; other site 762948001124 Plasmodium Vir superfamily; Provisional; Region: PTZ00473 762948001125 Predicted ATPases [General function prediction only]; Region: COG1106 762948001126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948001127 Walker A/P-loop; other site 762948001128 ATP binding site [chemical binding]; other site 762948001129 RloB-like protein; Region: RloB; pfam13707 762948001130 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762948001131 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 762948001132 substrate binding site [chemical binding]; other site 762948001133 oxyanion hole (OAH) forming residues; other site 762948001134 trimer interface [polypeptide binding]; other site 762948001135 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762948001136 acyl-activating enzyme (AAE) consensus motif; other site 762948001137 AMP binding site [chemical binding]; other site 762948001138 active site 762948001139 CoA binding site [chemical binding]; other site 762948001140 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 762948001141 UbiA prenyltransferase family; Region: UbiA; pfam01040 762948001142 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 762948001143 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 762948001144 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 762948001145 ResB-like family; Region: ResB; pfam05140 762948001146 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 762948001147 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 762948001148 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 762948001149 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 762948001150 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 762948001151 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762948001152 catalytic residues [active] 762948001153 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762948001154 catalytic core [active] 762948001155 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 762948001156 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762948001157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 762948001158 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762948001159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762948001160 dimerization interface [polypeptide binding]; other site 762948001161 putative DNA binding site [nucleotide binding]; other site 762948001162 putative Zn2+ binding site [ion binding]; other site 762948001163 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 762948001164 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 762948001165 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 762948001166 TrkA-N domain; Region: TrkA_N; pfam02254 762948001167 TrkA-C domain; Region: TrkA_C; pfam02080 762948001168 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 762948001169 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 762948001170 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 762948001171 Cl- selectivity filter; other site 762948001172 Cl- binding residues [ion binding]; other site 762948001173 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 762948001174 pore gating glutamate residue; other site 762948001175 dimer interface [polypeptide binding]; other site 762948001176 IncA protein; Region: IncA; pfam04156 762948001177 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 762948001178 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 762948001179 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 762948001180 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 762948001181 exopolyphosphatase; Region: exo_poly_only; TIGR03706 762948001182 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762948001183 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 762948001184 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 762948001185 active site 762948001186 interdomain interaction site; other site 762948001187 putative metal-binding site [ion binding]; other site 762948001188 nucleotide binding site [chemical binding]; other site 762948001189 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 762948001190 domain I; other site 762948001191 phosphate binding site [ion binding]; other site 762948001192 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 762948001193 domain II; other site 762948001194 domain III; other site 762948001195 nucleotide binding site [chemical binding]; other site 762948001196 DNA binding groove [nucleotide binding] 762948001197 catalytic site [active] 762948001198 domain IV; other site 762948001199 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 762948001200 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 762948001201 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 762948001202 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 762948001203 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 762948001204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948001205 S-adenosylmethionine binding site [chemical binding]; other site 762948001206 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 762948001207 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 762948001208 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 762948001209 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 762948001210 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 762948001211 active site residue [active] 762948001212 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 762948001213 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762948001214 ATP binding site [chemical binding]; other site 762948001215 putative Mg++ binding site [ion binding]; other site 762948001216 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 762948001217 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 762948001218 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762948001219 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 762948001220 Walker A motif; other site 762948001221 ATP binding site [chemical binding]; other site 762948001222 Walker B motif; other site 762948001223 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 762948001224 phosphoenolpyruvate synthase; Validated; Region: PRK06241 762948001225 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 762948001226 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 762948001227 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 762948001228 active site 762948001229 DNA binding site [nucleotide binding] 762948001230 catalytic site [active] 762948001231 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 762948001232 putative active site [active] 762948001233 putative CoA binding site [chemical binding]; other site 762948001234 nudix motif; other site 762948001235 metal binding site [ion binding]; metal-binding site 762948001236 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 762948001237 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762948001238 minor groove reading motif; other site 762948001239 helix-hairpin-helix signature motif; other site 762948001240 substrate binding pocket [chemical binding]; other site 762948001241 active site 762948001242 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 762948001243 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 762948001244 Dehydroquinase class II; Region: DHquinase_II; pfam01220 762948001245 trimer interface [polypeptide binding]; other site 762948001246 active site 762948001247 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762948001248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762948001249 NAD(P) binding site [chemical binding]; other site 762948001250 active site 762948001251 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 762948001252 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 762948001253 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762948001254 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762948001255 ligand binding site [chemical binding]; other site 762948001256 flexible hinge region; other site 762948001257 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 762948001258 non-specific DNA interactions [nucleotide binding]; other site 762948001259 DNA binding site [nucleotide binding] 762948001260 sequence specific DNA binding site [nucleotide binding]; other site 762948001261 putative cAMP binding site [chemical binding]; other site 762948001262 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 762948001263 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762948001264 NAD binding site [chemical binding]; other site 762948001265 substrate binding site [chemical binding]; other site 762948001266 putative active site [active] 762948001267 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762948001268 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 762948001269 putative NAD(P) binding site [chemical binding]; other site 762948001270 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 762948001271 nudix motif; other site 762948001272 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 762948001273 homotrimer interaction site [polypeptide binding]; other site 762948001274 putative active site [active] 762948001275 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 762948001276 Transglycosylase; Region: Transgly; pfam00912 762948001277 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 762948001278 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 762948001279 phosphodiesterase YaeI; Provisional; Region: PRK11340 762948001280 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762948001281 active site 762948001282 metal binding site [ion binding]; metal-binding site 762948001283 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762948001284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762948001285 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 762948001286 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762948001287 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762948001288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948001289 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762948001290 Walker A/P-loop; other site 762948001291 ATP binding site [chemical binding]; other site 762948001292 Q-loop/lid; other site 762948001293 ABC transporter signature motif; other site 762948001294 Walker B; other site 762948001295 D-loop; other site 762948001296 H-loop/switch region; other site 762948001297 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762948001298 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762948001299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948001300 Walker A/P-loop; other site 762948001301 ATP binding site [chemical binding]; other site 762948001302 Q-loop/lid; other site 762948001303 ABC transporter signature motif; other site 762948001304 Walker B; other site 762948001305 D-loop; other site 762948001306 H-loop/switch region; other site 762948001307 S-layer homology domain; Region: SLH; pfam00395 762948001308 S-layer homology domain; Region: SLH; pfam00395 762948001309 S-layer homology domain; Region: SLH; pfam00395 762948001310 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 762948001311 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 762948001312 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 762948001313 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 762948001314 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 762948001315 Moco binding site; other site 762948001316 metal coordination site [ion binding]; other site 762948001317 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 762948001318 RHS Repeat; Region: RHS_repeat; pfam05593 762948001319 RHS Repeat; Region: RHS_repeat; cl11982 762948001320 RHS Repeat; Region: RHS_repeat; pfam05593 762948001321 RHS Repeat; Region: RHS_repeat; pfam05593 762948001322 RHS Repeat; Region: RHS_repeat; pfam05593 762948001323 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 762948001324 RHS Repeat; Region: RHS_repeat; pfam05593 762948001325 RHS Repeat; Region: RHS_repeat; pfam05593 762948001326 RHS Repeat; Region: RHS_repeat; pfam05593 762948001327 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 762948001328 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 762948001329 nucleophilic elbow; other site 762948001330 catalytic triad; other site 762948001331 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 762948001332 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 762948001333 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 762948001334 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 762948001335 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 762948001336 Cysteine-rich domain; Region: CCG; pfam02754 762948001337 Cysteine-rich domain; Region: CCG; pfam02754 762948001338 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 762948001339 L-lactate permease; Region: Lactate_perm; cl00701 762948001340 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762948001341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762948001342 DNA-binding site [nucleotide binding]; DNA binding site 762948001343 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762948001344 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 762948001345 ATP binding site [chemical binding]; other site 762948001346 active site 762948001347 substrate binding site [chemical binding]; other site 762948001348 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 762948001349 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 762948001350 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 762948001351 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 762948001352 L-asparaginase II; Region: Asparaginase_II; pfam06089 762948001353 amidophosphoribosyltransferase; Provisional; Region: PRK07847 762948001354 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 762948001355 active site 762948001356 tetramer interface [polypeptide binding]; other site 762948001357 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762948001358 active site 762948001359 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 762948001360 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 762948001361 dimerization interface [polypeptide binding]; other site 762948001362 putative ATP binding site [chemical binding]; other site 762948001363 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 762948001364 active site 762948001365 catalytic triad [active] 762948001366 H+ Antiporter protein; Region: 2A0121; TIGR00900 762948001367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948001368 putative substrate translocation pore; other site 762948001369 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 762948001370 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 762948001371 Ligand binding site; other site 762948001372 Putative Catalytic site; other site 762948001373 DXD motif; other site 762948001374 Predicted membrane protein [Function unknown]; Region: COG2246 762948001375 GtrA-like protein; Region: GtrA; pfam04138 762948001376 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 762948001377 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948001378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948001379 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 762948001380 dimer interface [polypeptide binding]; other site 762948001381 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 762948001382 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 762948001383 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 762948001384 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 762948001385 putative metal binding residues [ion binding]; other site 762948001386 signature motif; other site 762948001387 dimer interface [polypeptide binding]; other site 762948001388 active site 762948001389 polyP binding site; other site 762948001390 substrate binding site [chemical binding]; other site 762948001391 acceptor-phosphate pocket; other site 762948001392 Excalibur calcium-binding domain; Region: Excalibur; smart00894 762948001393 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 762948001394 NAD-dependent deacetylase; Provisional; Region: PRK05333 762948001395 Predicted transcriptional regulators [Transcription]; Region: COG1695 762948001396 Transcriptional regulator PadR-like family; Region: PadR; cl17335 762948001397 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 762948001398 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 762948001399 putative NAD(P) binding site [chemical binding]; other site 762948001400 dimer interface [polypeptide binding]; other site 762948001401 Predicted transcriptional regulators [Transcription]; Region: COG1733 762948001402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762948001403 dimerization interface [polypeptide binding]; other site 762948001404 putative DNA binding site [nucleotide binding]; other site 762948001405 putative Zn2+ binding site [ion binding]; other site 762948001406 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 762948001407 Clp amino terminal domain; Region: Clp_N; pfam02861 762948001408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762948001409 Walker A motif; other site 762948001410 ATP binding site [chemical binding]; other site 762948001411 Walker B motif; other site 762948001412 arginine finger; other site 762948001413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762948001414 Walker A motif; other site 762948001415 ATP binding site [chemical binding]; other site 762948001416 Walker B motif; other site 762948001417 arginine finger; other site 762948001418 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762948001419 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 762948001420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762948001421 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762948001422 NAD(P) binding site [chemical binding]; other site 762948001423 active site 762948001424 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 762948001425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762948001426 motif II; other site 762948001427 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 762948001428 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 762948001429 dimerization interface [polypeptide binding]; other site 762948001430 DPS ferroxidase diiron center [ion binding]; other site 762948001431 ion pore; other site 762948001432 MMPL family; Region: MMPL; pfam03176 762948001433 MMPL family; Region: MMPL; pfam03176 762948001434 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 762948001435 diiron binding motif [ion binding]; other site 762948001436 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 762948001437 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 762948001438 CoA binding domain; Region: CoA_binding; smart00881 762948001439 CoA-ligase; Region: Ligase_CoA; pfam00549 762948001440 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 762948001441 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 762948001442 CoA-ligase; Region: Ligase_CoA; pfam00549 762948001443 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 762948001444 Part of AAA domain; Region: AAA_19; pfam13245 762948001445 Family description; Region: UvrD_C_2; pfam13538 762948001446 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 762948001447 dimer interface [polypeptide binding]; other site 762948001448 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 762948001449 dimer interface [polypeptide binding]; other site 762948001450 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 762948001451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 762948001452 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 762948001453 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 762948001454 NlpC/P60 family; Region: NLPC_P60; pfam00877 762948001455 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 762948001456 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 762948001457 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 762948001458 FeoA domain; Region: FeoA; cl00838 762948001459 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 762948001460 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762948001461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762948001462 active site 762948001463 phosphorylation site [posttranslational modification] 762948001464 intermolecular recognition site; other site 762948001465 dimerization interface [polypeptide binding]; other site 762948001466 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762948001467 DNA binding site [nucleotide binding] 762948001468 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 762948001469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762948001470 dimerization interface [polypeptide binding]; other site 762948001471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762948001472 dimer interface [polypeptide binding]; other site 762948001473 phosphorylation site [posttranslational modification] 762948001474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762948001475 ATP binding site [chemical binding]; other site 762948001476 Mg2+ binding site [ion binding]; other site 762948001477 G-X-G motif; other site 762948001478 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 762948001479 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 762948001480 RNA/DNA hybrid binding site [nucleotide binding]; other site 762948001481 active site 762948001482 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 762948001483 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 762948001484 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 762948001485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762948001486 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 762948001487 NAD(P) binding site [chemical binding]; other site 762948001488 active site 762948001489 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 762948001490 Isochorismatase family; Region: Isochorismatase; pfam00857 762948001491 catalytic triad [active] 762948001492 conserved cis-peptide bond; other site 762948001493 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 762948001494 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 762948001495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762948001496 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762948001497 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 762948001498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762948001499 non-specific DNA binding site [nucleotide binding]; other site 762948001500 salt bridge; other site 762948001501 sequence-specific DNA binding site [nucleotide binding]; other site 762948001502 DinB superfamily; Region: DinB_2; pfam12867 762948001503 MepB protein; Region: MepB; pfam08877 762948001504 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 762948001505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948001506 S-adenosylmethionine binding site [chemical binding]; other site 762948001507 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 762948001508 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 762948001509 ring oligomerisation interface [polypeptide binding]; other site 762948001510 ATP/Mg binding site [chemical binding]; other site 762948001511 stacking interactions; other site 762948001512 hinge regions; other site 762948001513 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 762948001514 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 762948001515 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 762948001516 ligand binding site [chemical binding]; other site 762948001517 active site 762948001518 UGI interface [polypeptide binding]; other site 762948001519 catalytic site [active] 762948001520 Uncharacterized conserved protein [Function unknown]; Region: COG2966 762948001521 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 762948001522 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 762948001523 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 762948001524 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 762948001525 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 762948001526 dimerization domain swap beta strand [polypeptide binding]; other site 762948001527 regulatory protein interface [polypeptide binding]; other site 762948001528 active site 762948001529 regulatory phosphorylation site [posttranslational modification]; other site 762948001530 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 762948001531 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 762948001532 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 762948001533 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 762948001534 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 762948001535 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 762948001536 active site 762948001537 phosphorylation site [posttranslational modification] 762948001538 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 762948001539 active site 762948001540 P-loop; other site 762948001541 phosphorylation site [posttranslational modification] 762948001542 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 762948001543 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 762948001544 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 762948001545 putative substrate binding site [chemical binding]; other site 762948001546 putative ATP binding site [chemical binding]; other site 762948001547 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 762948001548 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 762948001549 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 762948001550 VanZ like family; Region: VanZ; cl01971 762948001551 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762948001552 catalytic core [active] 762948001553 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762948001554 catalytic core [active] 762948001555 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762948001556 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762948001557 Walker A/P-loop; other site 762948001558 ATP binding site [chemical binding]; other site 762948001559 Q-loop/lid; other site 762948001560 ABC transporter signature motif; other site 762948001561 Walker B; other site 762948001562 D-loop; other site 762948001563 H-loop/switch region; other site 762948001564 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 762948001565 oligomeric interface; other site 762948001566 putative active site [active] 762948001567 homodimer interface [polypeptide binding]; other site 762948001568 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 762948001569 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 762948001570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762948001571 motif II; other site 762948001572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762948001573 dimer interface [polypeptide binding]; other site 762948001574 conserved gate region; other site 762948001575 ABC-ATPase subunit interface; other site 762948001576 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 762948001577 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 762948001578 Walker A/P-loop; other site 762948001579 ATP binding site [chemical binding]; other site 762948001580 Q-loop/lid; other site 762948001581 ABC transporter signature motif; other site 762948001582 Walker B; other site 762948001583 D-loop; other site 762948001584 H-loop/switch region; other site 762948001585 NIL domain; Region: NIL; pfam09383 762948001586 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 762948001587 Methyltransferase domain; Region: Methyltransf_26; pfam13659 762948001588 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 762948001589 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 762948001590 enoyl-CoA hydratase; Provisional; Region: PRK06688 762948001591 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762948001592 substrate binding site [chemical binding]; other site 762948001593 oxyanion hole (OAH) forming residues; other site 762948001594 trimer interface [polypeptide binding]; other site 762948001595 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762948001596 active site 2 [active] 762948001597 active site 1 [active] 762948001598 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762948001599 E3 interaction surface; other site 762948001600 lipoyl attachment site [posttranslational modification]; other site 762948001601 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762948001602 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762948001603 alpha subunit interface [polypeptide binding]; other site 762948001604 TPP binding site [chemical binding]; other site 762948001605 heterodimer interface [polypeptide binding]; other site 762948001606 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762948001607 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 762948001608 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762948001609 TPP-binding site [chemical binding]; other site 762948001610 tetramer interface [polypeptide binding]; other site 762948001611 heterodimer interface [polypeptide binding]; other site 762948001612 phosphorylation loop region [posttranslational modification] 762948001613 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 762948001614 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 762948001615 dimer interface [polypeptide binding]; other site 762948001616 active site 762948001617 CoA binding pocket [chemical binding]; other site 762948001618 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 762948001619 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 762948001620 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 762948001621 dimer interface [polypeptide binding]; other site 762948001622 active site 762948001623 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 762948001624 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762948001625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762948001626 NAD(P) binding site [chemical binding]; other site 762948001627 active site 762948001628 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 762948001629 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 762948001630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762948001631 motif II; other site 762948001632 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 762948001633 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 762948001634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948001635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762948001636 putative substrate translocation pore; other site 762948001637 SnoaL-like domain; Region: SnoaL_2; pfam12680 762948001638 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 762948001639 catalytic residues [active] 762948001640 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 762948001641 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 762948001642 acyl-activating enzyme (AAE) consensus motif; other site 762948001643 putative AMP binding site [chemical binding]; other site 762948001644 putative active site [active] 762948001645 putative CoA binding site [chemical binding]; other site 762948001646 maltose O-acetyltransferase; Provisional; Region: PRK10092 762948001647 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 762948001648 trimer interface [polypeptide binding]; other site 762948001649 active site 762948001650 substrate binding site [chemical binding]; other site 762948001651 CoA binding site [chemical binding]; other site 762948001652 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 762948001653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762948001654 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762948001655 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 762948001656 E3 interaction surface; other site 762948001657 lipoyl attachment site [posttranslational modification]; other site 762948001658 e3 binding domain; Region: E3_binding; pfam02817 762948001659 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 762948001660 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762948001661 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762948001662 alpha subunit interface [polypeptide binding]; other site 762948001663 TPP binding site [chemical binding]; other site 762948001664 heterodimer interface [polypeptide binding]; other site 762948001665 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762948001666 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 762948001667 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762948001668 tetramer interface [polypeptide binding]; other site 762948001669 TPP-binding site [chemical binding]; other site 762948001670 heterodimer interface [polypeptide binding]; other site 762948001671 phosphorylation loop region [posttranslational modification] 762948001672 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 762948001673 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762948001674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948001675 homodimer interface [polypeptide binding]; other site 762948001676 catalytic residue [active] 762948001677 Laminin Domain I; Region: Laminin_I; pfam06008 762948001678 adenylosuccinate lyase; Provisional; Region: PRK09285 762948001679 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 762948001680 tetramer interface [polypeptide binding]; other site 762948001681 active site 762948001682 Divergent AAA domain; Region: AAA_4; pfam04326 762948001683 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 762948001684 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 762948001685 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 762948001686 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 762948001687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762948001688 Thioredoxin; Region: Thioredoxin_4; cl17273 762948001689 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 762948001690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948001691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948001692 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 762948001693 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 762948001694 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 762948001695 NAD(P) binding site [chemical binding]; other site 762948001696 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762948001697 catalytic core [active] 762948001698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762948001699 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762948001700 DNA binding site [nucleotide binding] 762948001701 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762948001702 active site 762948001703 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 762948001704 potential frameshift: common BLAST hit: gi|283458147|ref|YP_003362763.1| Rhs family protein 762948001705 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 762948001706 RHS Repeat; Region: RHS_repeat; cl11982 762948001707 RHS Repeat; Region: RHS_repeat; pfam05593 762948001708 RHS Repeat; Region: RHS_repeat; pfam05593 762948001709 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 762948001710 RHS Repeat; Region: RHS_repeat; pfam05593 762948001711 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 762948001712 RHS Repeat; Region: RHS_repeat; pfam05593 762948001713 RHS Repeat; Region: RHS_repeat; pfam05593 762948001714 RHS Repeat; Region: RHS_repeat; pfam05593 762948001715 RHS Repeat; Region: RHS_repeat; pfam05593 762948001716 RHS Repeat; Region: RHS_repeat; cl11982 762948001717 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948001718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948001719 Predicted membrane protein [Function unknown]; Region: COG1511 762948001720 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762948001721 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 762948001722 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 762948001723 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 762948001724 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 762948001725 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 762948001726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948001727 Walker A/P-loop; other site 762948001728 ATP binding site [chemical binding]; other site 762948001729 Q-loop/lid; other site 762948001730 ABC transporter signature motif; other site 762948001731 Walker B; other site 762948001732 D-loop; other site 762948001733 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 762948001734 nucleoside/Zn binding site; other site 762948001735 dimer interface [polypeptide binding]; other site 762948001736 catalytic motif [active] 762948001737 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762948001738 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762948001739 ATP binding site [chemical binding]; other site 762948001740 putative Mg++ binding site [ion binding]; other site 762948001741 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762948001742 nucleotide binding region [chemical binding]; other site 762948001743 ATP-binding site [chemical binding]; other site 762948001744 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 762948001745 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762948001746 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 762948001747 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 762948001748 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 762948001749 active site 762948001750 Putative sensor; Region: Sensor; pfam13796 762948001751 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 762948001752 Histidine kinase; Region: HisKA_3; pfam07730 762948001753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762948001754 ATP binding site [chemical binding]; other site 762948001755 Mg2+ binding site [ion binding]; other site 762948001756 G-X-G motif; other site 762948001757 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762948001758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762948001759 active site 762948001760 phosphorylation site [posttranslational modification] 762948001761 intermolecular recognition site; other site 762948001762 dimerization interface [polypeptide binding]; other site 762948001763 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762948001764 DNA binding residues [nucleotide binding] 762948001765 dimerization interface [polypeptide binding]; other site 762948001766 Uncharacterized conserved protein [Function unknown]; Region: COG2128 762948001767 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 762948001768 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 762948001769 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 762948001770 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 762948001771 active site 762948001772 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 762948001773 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 762948001774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948001775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948001776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948001777 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762948001778 putative substrate translocation pore; other site 762948001779 DNA repair protein RadA; Provisional; Region: PRK11823 762948001780 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762948001781 Walker A motif; other site 762948001782 ATP binding site [chemical binding]; other site 762948001783 Walker B motif; other site 762948001784 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 762948001785 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 762948001786 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 762948001787 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 762948001788 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762948001789 endonuclease III; Region: ENDO3c; smart00478 762948001790 minor groove reading motif; other site 762948001791 helix-hairpin-helix signature motif; other site 762948001792 substrate binding pocket [chemical binding]; other site 762948001793 active site 762948001794 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 762948001795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762948001796 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762948001797 NAD(P) binding site [chemical binding]; other site 762948001798 active site 762948001799 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762948001800 MarR family; Region: MarR_2; pfam12802 762948001801 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 762948001802 Clp amino terminal domain; Region: Clp_N; pfam02861 762948001803 Clp amino terminal domain; Region: Clp_N; pfam02861 762948001804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762948001805 Walker A motif; other site 762948001806 ATP binding site [chemical binding]; other site 762948001807 Walker B motif; other site 762948001808 arginine finger; other site 762948001809 UvrB/uvrC motif; Region: UVR; pfam02151 762948001810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762948001811 Walker A motif; other site 762948001812 ATP binding site [chemical binding]; other site 762948001813 Walker B motif; other site 762948001814 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762948001815 Lsr2; Region: Lsr2; pfam11774 762948001816 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 762948001817 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 762948001818 putative anticodon binding site; other site 762948001819 dimer interface [polypeptide binding]; other site 762948001820 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762948001821 motif 1; other site 762948001822 dimer interface [polypeptide binding]; other site 762948001823 active site 762948001824 motif 2; other site 762948001825 motif 3; other site 762948001826 pantoate--beta-alanine ligase; Region: panC; TIGR00018 762948001827 Pantoate-beta-alanine ligase; Region: PanC; cd00560 762948001828 active site 762948001829 ATP-binding site [chemical binding]; other site 762948001830 pantoate-binding site; other site 762948001831 HXXH motif; other site 762948001832 Rossmann-like domain; Region: Rossmann-like; pfam10727 762948001833 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 762948001834 Predicted membrane protein [Function unknown]; Region: COG3428 762948001835 Bacterial PH domain; Region: DUF304; pfam03703 762948001836 Bacterial PH domain; Region: DUF304; cl01348 762948001837 Bacterial PH domain; Region: DUF304; cl01348 762948001838 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 762948001839 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 762948001840 catalytic center binding site [active] 762948001841 ATP binding site [chemical binding]; other site 762948001842 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 762948001843 active site 762948001844 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 762948001845 dihydropteroate synthase; Region: DHPS; TIGR01496 762948001846 substrate binding pocket [chemical binding]; other site 762948001847 dimer interface [polypeptide binding]; other site 762948001848 inhibitor binding site; inhibition site 762948001849 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762948001850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762948001851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762948001852 Coenzyme A binding pocket [chemical binding]; other site 762948001853 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 762948001854 homodecamer interface [polypeptide binding]; other site 762948001855 GTP cyclohydrolase I; Provisional; Region: PLN03044 762948001856 active site 762948001857 putative catalytic site residues [active] 762948001858 zinc binding site [ion binding]; other site 762948001859 GTP-CH-I/GFRP interaction surface; other site 762948001860 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 762948001861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762948001862 Walker A motif; other site 762948001863 ATP binding site [chemical binding]; other site 762948001864 Walker B motif; other site 762948001865 arginine finger; other site 762948001866 Peptidase family M41; Region: Peptidase_M41; pfam01434 762948001867 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 762948001868 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762948001869 active site 762948001870 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 762948001871 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 762948001872 Ligand Binding Site [chemical binding]; other site 762948001873 putative hydrolase; Region: TIGR03624 762948001874 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 762948001875 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 762948001876 dimer interface [polypeptide binding]; other site 762948001877 substrate binding site [chemical binding]; other site 762948001878 metal binding sites [ion binding]; metal-binding site 762948001879 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 762948001880 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 762948001881 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 762948001882 AAA domain; Region: AAA_12; pfam13087 762948001883 Protein of unknown function, DUF393; Region: DUF393; pfam04134 762948001884 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 762948001885 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 762948001886 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 762948001887 FeoA domain; Region: FeoA; pfam04023 762948001888 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 762948001889 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762948001890 ABC-ATPase subunit interface; other site 762948001891 dimer interface [polypeptide binding]; other site 762948001892 putative PBP binding regions; other site 762948001893 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 762948001894 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 762948001895 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 762948001896 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 762948001897 metal binding site [ion binding]; metal-binding site 762948001898 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762948001899 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 762948001900 putative catalytic site [active] 762948001901 putative phosphate binding site [ion binding]; other site 762948001902 active site 762948001903 metal binding site A [ion binding]; metal-binding site 762948001904 DNA binding site [nucleotide binding] 762948001905 putative AP binding site [nucleotide binding]; other site 762948001906 putative metal binding site B [ion binding]; other site 762948001907 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 762948001908 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 762948001909 Peptidase family M48; Region: Peptidase_M48; pfam01435 762948001910 DDE superfamily endonuclease; Region: DDE_4; cl17710 762948001911 propionate/acetate kinase; Provisional; Region: PRK12379 762948001912 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 762948001913 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 762948001914 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 762948001915 multidrug efflux protein; Reviewed; Region: PRK09577 762948001916 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 762948001917 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762948001918 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762948001919 Walker A/P-loop; other site 762948001920 ATP binding site [chemical binding]; other site 762948001921 Q-loop/lid; other site 762948001922 ABC transporter signature motif; other site 762948001923 Walker B; other site 762948001924 D-loop; other site 762948001925 H-loop/switch region; other site 762948001926 Protein of unknown function (DUF493); Region: DUF493; cl01102 762948001927 seryl-tRNA synthetase; Provisional; Region: PRK05431 762948001928 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 762948001929 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 762948001930 dimer interface [polypeptide binding]; other site 762948001931 active site 762948001932 motif 1; other site 762948001933 motif 2; other site 762948001934 motif 3; other site 762948001935 prephenate dehydratase; Provisional; Region: PRK11898 762948001936 Prephenate dehydratase; Region: PDT; pfam00800 762948001937 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 762948001938 putative L-Phe binding site [chemical binding]; other site 762948001939 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 762948001940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948001941 S-adenosylmethionine binding site [chemical binding]; other site 762948001942 Domain of unknown function DUF77; Region: DUF77; pfam01910 762948001943 phosphate acetyltransferase; Reviewed; Region: PRK05632 762948001944 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762948001945 DRTGG domain; Region: DRTGG; pfam07085 762948001946 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 762948001947 Protein of unknown function DUF86; Region: DUF86; cl01031 762948001948 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762948001949 active site 762948001950 NTP binding site [chemical binding]; other site 762948001951 metal binding triad [ion binding]; metal-binding site 762948001952 antibiotic binding site [chemical binding]; other site 762948001953 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 762948001954 putative homodimer interface [polypeptide binding]; other site 762948001955 putative homotetramer interface [polypeptide binding]; other site 762948001956 putative allosteric switch controlling residues; other site 762948001957 putative metal binding site [ion binding]; other site 762948001958 putative homodimer-homodimer interface [polypeptide binding]; other site 762948001959 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762948001960 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762948001961 metal-binding site [ion binding] 762948001962 Protein of unknown function (DUF975); Region: DUF975; cl10504 762948001963 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762948001964 Soluble P-type ATPase [General function prediction only]; Region: COG4087 762948001965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948001966 S-adenosylmethionine binding site [chemical binding]; other site 762948001967 Domain of unknown function (DUF2703); Region: DUF2703; pfam10865 762948001968 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 762948001969 dimer interface [polypeptide binding]; other site 762948001970 FMN binding site [chemical binding]; other site 762948001971 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 762948001972 dimer interface [polypeptide binding]; other site 762948001973 FMN binding site [chemical binding]; other site 762948001974 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 762948001975 dimer interface [polypeptide binding]; other site 762948001976 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762948001977 conserved cys residue [active] 762948001978 Asp23 family; Region: Asp23; pfam03780 762948001979 Asp23 family; Region: Asp23; cl00574 762948001980 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 762948001981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762948001982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762948001983 DNA binding residues [nucleotide binding] 762948001984 Asp23 family; Region: Asp23; cl00574 762948001985 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 762948001986 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 762948001987 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762948001988 RNA binding surface [nucleotide binding]; other site 762948001989 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 762948001990 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948001991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948001992 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 762948001993 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 762948001994 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 762948001995 active site 762948001996 catalytic site [active] 762948001997 metal binding site [ion binding]; metal-binding site 762948001998 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 762948001999 HPr interaction site; other site 762948002000 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762948002001 active site 762948002002 phosphorylation site [posttranslational modification] 762948002003 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 762948002004 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 762948002005 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 762948002006 active site 762948002007 intersubunit interface [polypeptide binding]; other site 762948002008 zinc binding site [ion binding]; other site 762948002009 Na+ binding site [ion binding]; other site 762948002010 L-asparagine permease; Provisional; Region: PRK15049 762948002011 ornithine cyclodeaminase; Validated; Region: PRK07589 762948002012 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 762948002013 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 762948002014 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762948002015 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762948002016 active site 762948002017 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 762948002018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 762948002019 active site 762948002020 motif I; other site 762948002021 motif II; other site 762948002022 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 762948002023 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 762948002024 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 762948002025 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762948002026 active site residue [active] 762948002027 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 762948002028 POT family; Region: PTR2; cl17359 762948002029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948002030 putative substrate translocation pore; other site 762948002031 Fic family protein [Function unknown]; Region: COG3177 762948002032 Fic/DOC family; Region: Fic; pfam02661 762948002033 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 762948002034 putative DNA binding helix; other site 762948002035 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 762948002036 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762948002037 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762948002038 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 762948002039 RES domain; Region: RES; cl02411 762948002040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762948002041 non-specific DNA binding site [nucleotide binding]; other site 762948002042 salt bridge; other site 762948002043 sequence-specific DNA binding site [nucleotide binding]; other site 762948002044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762948002045 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762948002046 active site 762948002047 motif I; other site 762948002048 motif II; other site 762948002049 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 762948002050 substrate binding site [chemical binding]; other site 762948002051 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 762948002052 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 762948002053 putative substrate binding site [chemical binding]; other site 762948002054 putative ATP binding site [chemical binding]; other site 762948002055 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 762948002056 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 762948002057 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 762948002058 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762948002059 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 762948002060 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 762948002061 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762948002062 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762948002063 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 762948002064 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 762948002065 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762948002066 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 762948002067 NAD(P) binding site [chemical binding]; other site 762948002068 Domain of unknown function (DUF955); Region: DUF955; pfam06114 762948002069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762948002070 sequence-specific DNA binding site [nucleotide binding]; other site 762948002071 salt bridge; other site 762948002072 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762948002073 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762948002074 active site 762948002075 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762948002076 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762948002077 active site 762948002078 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 762948002079 Acyltransferase family; Region: Acyl_transf_3; pfam01757 762948002080 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 762948002081 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 762948002082 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 762948002083 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762948002084 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 762948002085 Ligand binding site; other site 762948002086 Putative Catalytic site; other site 762948002087 DXD motif; other site 762948002088 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 762948002089 acetylornithine deacetylase; Provisional; Region: PRK07522 762948002090 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 762948002091 metal binding site [ion binding]; metal-binding site 762948002092 putative dimer interface [polypeptide binding]; other site 762948002093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948002094 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762948002095 putative substrate translocation pore; other site 762948002096 Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534 762948002097 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 762948002098 amphipathic channel; other site 762948002099 Asn-Pro-Ala signature motifs; other site 762948002100 VanZ like family; Region: VanZ; pfam04892 762948002101 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 762948002102 classical (c) SDRs; Region: SDR_c; cd05233 762948002103 NAD(P) binding site [chemical binding]; other site 762948002104 active site 762948002105 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762948002106 catalytic core [active] 762948002107 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 762948002108 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 762948002109 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 762948002110 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 762948002111 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 762948002112 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 762948002113 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 762948002114 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 762948002115 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 762948002116 active site 762948002117 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 762948002118 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 762948002119 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 762948002120 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762948002121 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762948002122 active site 762948002123 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762948002124 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762948002125 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762948002126 active site 762948002127 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 762948002128 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 762948002129 acyl-activating enzyme (AAE) consensus motif; other site 762948002130 active site 762948002131 CrcB-like protein; Region: CRCB; pfam02537 762948002132 CrcB-like protein; Region: CRCB; pfam02537 762948002133 potential frameshift: common BLAST hit: gi|283457126|ref|YP_003361690.1| predicted drug exporter of the RND superfamily 762948002134 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 762948002135 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 762948002136 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 762948002137 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 762948002138 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 762948002139 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948002140 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948002141 HAMP domain; Region: HAMP; pfam00672 762948002142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762948002143 dimer interface [polypeptide binding]; other site 762948002144 phosphorylation site [posttranslational modification] 762948002145 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 762948002146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762948002147 ATP binding site [chemical binding]; other site 762948002148 Mg2+ binding site [ion binding]; other site 762948002149 G-X-G motif; other site 762948002150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762948002151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762948002152 active site 762948002153 phosphorylation site [posttranslational modification] 762948002154 intermolecular recognition site; other site 762948002155 dimerization interface [polypeptide binding]; other site 762948002156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762948002157 DNA binding site [nucleotide binding] 762948002158 transcriptional antiterminator BglG; Provisional; Region: PRK09772 762948002159 CAT RNA binding domain; Region: CAT_RBD; smart01061 762948002160 PRD domain; Region: PRD; pfam00874 762948002161 PRD domain; Region: PRD; pfam00874 762948002162 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 762948002163 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 762948002164 active pocket/dimerization site; other site 762948002165 active site 762948002166 phosphorylation site [posttranslational modification] 762948002167 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 762948002168 active site 762948002169 phosphorylation site [posttranslational modification] 762948002170 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 762948002171 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 762948002172 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762948002173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762948002174 active site 762948002175 motif I; other site 762948002176 motif II; other site 762948002177 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 762948002178 biotin synthase; Validated; Region: PRK06256 762948002179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948002180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948002181 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 762948002182 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 762948002183 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 762948002184 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762948002185 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 762948002186 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 762948002187 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 762948002188 shikimate binding site; other site 762948002189 NAD(P) binding site [chemical binding]; other site 762948002190 Rhomboid family; Region: Rhomboid; pfam01694 762948002191 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 762948002192 active site 762948002193 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 762948002194 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 762948002195 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 762948002196 DNA gyrase subunit A; Validated; Region: PRK05560 762948002197 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 762948002198 CAP-like domain; other site 762948002199 active site 762948002200 primary dimer interface [polypeptide binding]; other site 762948002201 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762948002202 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762948002203 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762948002204 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762948002205 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762948002206 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762948002207 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 762948002208 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 762948002209 anchoring element; other site 762948002210 dimer interface [polypeptide binding]; other site 762948002211 ATP binding site [chemical binding]; other site 762948002212 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 762948002213 active site 762948002214 putative metal-binding site [ion binding]; other site 762948002215 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762948002216 Protein of unknown function (DUF721); Region: DUF721; cl02324 762948002217 recombination protein F; Reviewed; Region: recF; PRK00064 762948002218 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 762948002219 Walker A/P-loop; other site 762948002220 ATP binding site [chemical binding]; other site 762948002221 Q-loop/lid; other site 762948002222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948002223 ABC transporter signature motif; other site 762948002224 Walker B; other site 762948002225 D-loop; other site 762948002226 H-loop/switch region; other site 762948002227 DNA polymerase III subunit beta; Validated; Region: PRK07761 762948002228 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 762948002229 putative DNA binding surface [nucleotide binding]; other site 762948002230 dimer interface [polypeptide binding]; other site 762948002231 beta-clamp/clamp loader binding surface; other site 762948002232 beta-clamp/translesion DNA polymerase binding surface; other site 762948002233 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 762948002234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762948002235 Walker A motif; other site 762948002236 ATP binding site [chemical binding]; other site 762948002237 Walker B motif; other site 762948002238 arginine finger; other site 762948002239 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 762948002240 DnaA box-binding interface [nucleotide binding]; other site 762948002241 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 762948002242 Ribonuclease P; Region: Ribonuclease_P; cl00457 762948002243 Haemolytic domain; Region: Haemolytic; pfam01809 762948002244 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 762948002245 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 762948002246 G-X-X-G motif; other site 762948002247 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 762948002248 RxxxH motif; other site 762948002249 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 762948002250 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 762948002251 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762948002252 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762948002253 P-loop; other site 762948002254 Magnesium ion binding site [ion binding]; other site 762948002255 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762948002256 Magnesium ion binding site [ion binding]; other site 762948002257 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 762948002258 ParB-like nuclease domain; Region: ParBc; pfam02195 762948002259 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762948002260 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762948002261 catalytic residues [active] 762948002262 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 762948002263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762948002264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762948002265 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 762948002266 MviN-like protein; Region: MVIN; pfam03023 762948002267 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 762948002268 active site 762948002269 Ap6A binding site [chemical binding]; other site 762948002270 nudix motif; other site 762948002271 metal binding site [ion binding]; metal-binding site 762948002272 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 762948002273 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 762948002274 active site 762948002275 NTP binding site [chemical binding]; other site 762948002276 metal binding triad [ion binding]; metal-binding site 762948002277 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 762948002278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762948002279 Zn2+ binding site [ion binding]; other site 762948002280 Mg2+ binding site [ion binding]; other site 762948002281 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 762948002282 TM2 domain; Region: TM2; pfam05154 762948002283 TM2 domain; Region: TM2; pfam05154 762948002284 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 762948002285 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 762948002286 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 762948002287 dimer interface [polypeptide binding]; other site 762948002288 ssDNA binding site [nucleotide binding]; other site 762948002289 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762948002290 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 762948002291 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 762948002292 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 762948002293 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 762948002294 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762948002295 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 762948002296 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762948002297 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 762948002298 Walker A/P-loop; other site 762948002299 ATP binding site [chemical binding]; other site 762948002300 Q-loop/lid; other site 762948002301 ABC transporter signature motif; other site 762948002302 Walker B; other site 762948002303 D-loop; other site 762948002304 H-loop/switch region; other site 762948002305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948002306 S-adenosylmethionine binding site [chemical binding]; other site 762948002307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762948002308 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 762948002309 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 762948002310 active site 762948002311 TDP-binding site; other site 762948002312 homodimer interface [polypeptide binding]; other site 762948002313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762948002314 NAD(P) binding site [chemical binding]; other site 762948002315 active site 762948002316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762948002317 replicative DNA helicase; Region: DnaB; TIGR00665 762948002318 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 762948002319 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 762948002320 Walker A motif; other site 762948002321 ATP binding site [chemical binding]; other site 762948002322 Walker B motif; other site 762948002323 DNA binding loops [nucleotide binding] 762948002324 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 762948002325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762948002326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762948002327 dimerization interface [polypeptide binding]; other site 762948002328 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 762948002329 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 762948002330 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 762948002331 active site 762948002332 catalytic site [active] 762948002333 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 762948002334 Glutamine amidotransferase class-I; Region: GATase; pfam00117 762948002335 glutamine binding [chemical binding]; other site 762948002336 catalytic triad [active] 762948002337 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 762948002338 Catalytic domain of Protein Kinases; Region: PKc; cd00180 762948002339 active site 762948002340 ATP binding site [chemical binding]; other site 762948002341 substrate binding site [chemical binding]; other site 762948002342 activation loop (A-loop); other site 762948002343 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762948002344 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762948002345 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762948002346 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 762948002347 Catalytic domain of Protein Kinases; Region: PKc; cd00180 762948002348 active site 762948002349 ATP binding site [chemical binding]; other site 762948002350 substrate binding site [chemical binding]; other site 762948002351 activation loop (A-loop); other site 762948002352 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762948002353 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762948002354 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 762948002355 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 762948002356 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 762948002357 active site 762948002358 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 762948002359 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 762948002360 phosphopeptide binding site; other site 762948002361 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 762948002362 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 762948002363 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 762948002364 phosphopeptide binding site; other site 762948002365 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 762948002366 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 762948002367 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 762948002368 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 762948002369 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 762948002370 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 762948002371 dimer interface [polypeptide binding]; other site 762948002372 putative anticodon binding site; other site 762948002373 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762948002374 motif 1; other site 762948002375 dimer interface [polypeptide binding]; other site 762948002376 active site 762948002377 motif 2; other site 762948002378 motif 3; other site 762948002379 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 762948002380 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 762948002381 Ferritin-like domain; Region: Ferritin; pfam00210 762948002382 ferroxidase diiron center [ion binding]; other site 762948002383 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762948002384 MarR family; Region: MarR; pfam01047 762948002385 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 762948002386 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 762948002387 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 762948002388 Divergent AAA domain; Region: AAA_4; pfam04326 762948002389 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 762948002390 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 762948002391 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 762948002392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762948002393 Helix-turn-helix domain; Region: HTH_18; pfam12833 762948002394 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 762948002395 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762948002396 DNA binding site [nucleotide binding] 762948002397 active site 762948002398 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 762948002399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948002400 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762948002401 Walker A/P-loop; other site 762948002402 ATP binding site [chemical binding]; other site 762948002403 Q-loop/lid; other site 762948002404 ABC transporter signature motif; other site 762948002405 Walker B; other site 762948002406 D-loop; other site 762948002407 H-loop/switch region; other site 762948002408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948002409 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762948002410 Walker A/P-loop; other site 762948002411 ATP binding site [chemical binding]; other site 762948002412 Q-loop/lid; other site 762948002413 ABC transporter signature motif; other site 762948002414 Walker B; other site 762948002415 D-loop; other site 762948002416 H-loop/switch region; other site 762948002417 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762948002418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948002419 Walker A/P-loop; other site 762948002420 ATP binding site [chemical binding]; other site 762948002421 Q-loop/lid; other site 762948002422 ABC transporter signature motif; other site 762948002423 Walker B; other site 762948002424 D-loop; other site 762948002425 H-loop/switch region; other site 762948002426 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762948002427 Methyltransferase domain; Region: Methyltransf_31; pfam13847 762948002428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948002429 S-adenosylmethionine binding site [chemical binding]; other site 762948002430 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 762948002431 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 762948002432 nudix motif; other site 762948002433 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 762948002434 Uncharacterized conserved protein [Function unknown]; Region: COG1359 762948002435 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 762948002436 hydrophobic ligand binding site; other site 762948002437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948002438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948002439 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 762948002440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948002441 putative substrate translocation pore; other site 762948002442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948002443 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 762948002444 Tubby C 2; Region: Tub_2; cl02043 762948002445 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 762948002446 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 762948002447 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 762948002448 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 762948002449 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 762948002450 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762948002451 catalytic Zn binding site [ion binding]; other site 762948002452 structural Zn binding site [ion binding]; other site 762948002453 NAD(P) binding site [chemical binding]; other site 762948002454 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 762948002455 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 762948002456 Sulfate transporter family; Region: Sulfate_transp; pfam00916 762948002457 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 762948002458 active site clefts [active] 762948002459 zinc binding site [ion binding]; other site 762948002460 dimer interface [polypeptide binding]; other site 762948002461 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 762948002462 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762948002463 ABC-ATPase subunit interface; other site 762948002464 dimer interface [polypeptide binding]; other site 762948002465 putative PBP binding regions; other site 762948002466 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 762948002467 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 762948002468 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 762948002469 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 762948002470 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 762948002471 intersubunit interface [polypeptide binding]; other site 762948002472 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 762948002473 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 762948002474 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 762948002475 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 762948002476 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 762948002477 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 762948002478 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 762948002479 Catalytic domain of Protein Kinases; Region: PKc; cd00180 762948002480 active site 762948002481 ATP binding site [chemical binding]; other site 762948002482 substrate binding site [chemical binding]; other site 762948002483 activation loop (A-loop); other site 762948002484 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762948002485 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cd01391 762948002486 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 762948002487 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 762948002488 phosphopeptide binding site; other site 762948002489 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 762948002490 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 762948002491 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 762948002492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948002493 Walker A/P-loop; other site 762948002494 ATP binding site [chemical binding]; other site 762948002495 RHS Repeat; Region: RHS_repeat; cl11982 762948002496 RHS Repeat; Region: RHS_repeat; pfam05593 762948002497 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 762948002498 RHS Repeat; Region: RHS_repeat; pfam05593 762948002499 RHS Repeat; Region: RHS_repeat; cl11982 762948002500 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 762948002501 RHS Repeat; Region: RHS_repeat; pfam05593 762948002502 RHS Repeat; Region: RHS_repeat; pfam05593 762948002503 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 762948002504 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 762948002505 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 762948002506 RHS Repeat; Region: RHS_repeat; pfam05593 762948002507 RHS Repeat; Region: RHS_repeat; pfam05593 762948002508 RHS Repeat; Region: RHS_repeat; pfam05593 762948002509 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 762948002510 RHS Repeat; Region: RHS_repeat; cl11982 762948002511 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 762948002512 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 762948002513 RHS Repeat; Region: RHS_repeat; pfam05593 762948002514 RHS Repeat; Region: RHS_repeat; pfam05593 762948002515 RHS Repeat; Region: RHS_repeat; pfam05593 762948002516 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 762948002517 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 762948002518 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 762948002519 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 762948002520 NAD binding site [chemical binding]; other site 762948002521 substrate binding site [chemical binding]; other site 762948002522 catalytic Zn binding site [ion binding]; other site 762948002523 tetramer interface [polypeptide binding]; other site 762948002524 structural Zn binding site [ion binding]; other site 762948002525 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 762948002526 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 762948002527 putative metal binding site [ion binding]; other site 762948002528 hypothetical protein; Provisional; Region: PRK14013 762948002529 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 762948002530 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 762948002531 putative metal binding site [ion binding]; other site 762948002532 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 762948002533 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 762948002534 putative metal binding site [ion binding]; other site 762948002535 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 762948002536 H+ Antiporter protein; Region: 2A0121; TIGR00900 762948002537 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 762948002538 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 762948002539 active site 762948002540 Zn binding site [ion binding]; other site 762948002541 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 762948002542 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 762948002543 THF binding site; other site 762948002544 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 762948002545 substrate binding site [chemical binding]; other site 762948002546 THF binding site; other site 762948002547 zinc-binding site [ion binding]; other site 762948002548 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 762948002549 FAD binding site [chemical binding]; other site 762948002550 adenylosuccinate lyase; Provisional; Region: PRK09285 762948002551 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762948002552 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 762948002553 active site 762948002554 catalytic tetrad [active] 762948002555 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 762948002556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948002557 putative substrate translocation pore; other site 762948002558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948002559 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 762948002560 Cytochrome P450; Region: p450; cl12078 762948002561 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 762948002562 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762948002563 Flavoprotein; Region: Flavoprotein; cl08021 762948002564 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 762948002565 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762948002566 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 762948002567 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 762948002568 active site 762948002569 zinc binding site [ion binding]; other site 762948002570 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 762948002571 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 762948002572 putative active site [active] 762948002573 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762948002574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948002575 Walker A/P-loop; other site 762948002576 ATP binding site [chemical binding]; other site 762948002577 Q-loop/lid; other site 762948002578 ABC transporter signature motif; other site 762948002579 Walker B; other site 762948002580 D-loop; other site 762948002581 H-loop/switch region; other site 762948002582 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 762948002583 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 762948002584 active site 762948002585 zinc binding site [ion binding]; other site 762948002586 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 762948002587 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 762948002588 putative active site [active] 762948002589 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762948002590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948002591 Walker A/P-loop; other site 762948002592 ATP binding site [chemical binding]; other site 762948002593 Q-loop/lid; other site 762948002594 ABC transporter signature motif; other site 762948002595 Walker B; other site 762948002596 D-loop; other site 762948002597 H-loop/switch region; other site 762948002598 Tubby C 2; Region: Tub_2; cl02043 762948002599 Frizzled/Smoothened family membrane region; Region: Frizzled; pfam01534 762948002600 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 762948002601 dimer interface [polypeptide binding]; other site 762948002602 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762948002603 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 762948002604 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762948002605 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762948002606 catalytic residue [active] 762948002607 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 762948002608 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 762948002609 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 762948002610 putative active site [active] 762948002611 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762948002612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948002613 Walker A/P-loop; other site 762948002614 ATP binding site [chemical binding]; other site 762948002615 Q-loop/lid; other site 762948002616 ABC transporter signature motif; other site 762948002617 Walker B; other site 762948002618 D-loop; other site 762948002619 H-loop/switch region; other site 762948002620 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 762948002621 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 762948002622 active site 762948002623 zinc binding site [ion binding]; other site 762948002624 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762948002625 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762948002626 Walker A/P-loop; other site 762948002627 ATP binding site [chemical binding]; other site 762948002628 Q-loop/lid; other site 762948002629 ABC transporter signature motif; other site 762948002630 Walker B; other site 762948002631 D-loop; other site 762948002632 H-loop/switch region; other site 762948002633 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762948002634 FtsX-like permease family; Region: FtsX; pfam02687 762948002635 FtsX-like permease family; Region: FtsX; pfam02687 762948002636 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 762948002637 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 762948002638 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 762948002639 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 762948002640 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 762948002641 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 762948002642 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 762948002643 active site 762948002644 metal binding site [ion binding]; metal-binding site 762948002645 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 762948002646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948002647 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 762948002648 Walker A/P-loop; other site 762948002649 ATP binding site [chemical binding]; other site 762948002650 Q-loop/lid; other site 762948002651 ABC transporter signature motif; other site 762948002652 Walker B; other site 762948002653 D-loop; other site 762948002654 H-loop/switch region; other site 762948002655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 762948002656 Histidine kinase; Region: HisKA_3; pfam07730 762948002657 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762948002658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762948002659 active site 762948002660 phosphorylation site [posttranslational modification] 762948002661 intermolecular recognition site; other site 762948002662 dimerization interface [polypeptide binding]; other site 762948002663 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762948002664 DNA binding residues [nucleotide binding] 762948002665 dimerization interface [polypeptide binding]; other site 762948002666 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762948002667 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762948002668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948002669 Walker A/P-loop; other site 762948002670 ATP binding site [chemical binding]; other site 762948002671 Q-loop/lid; other site 762948002672 ABC transporter signature motif; other site 762948002673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 762948002674 Walker B; other site 762948002675 Walker B; other site 762948002676 D-loop; other site 762948002677 D-loop; other site 762948002678 H-loop/switch region; other site 762948002679 H-loop/switch region; other site 762948002680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 762948002681 AAA domain; Region: AAA_22; pfam13401 762948002682 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 762948002683 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 762948002684 predicted active site [active] 762948002685 catalytic triad [active] 762948002686 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 762948002687 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 762948002688 active site 762948002689 multimer interface [polypeptide binding]; other site 762948002690 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762948002691 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 762948002692 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762948002693 EamA-like transporter family; Region: EamA; pfam00892 762948002694 MarR family; Region: MarR_2; cl17246 762948002695 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762948002696 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 762948002697 hydrophobic ligand binding site; other site 762948002698 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762948002699 MarR family; Region: MarR; pfam01047 762948002700 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 762948002701 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 762948002702 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 762948002703 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 762948002704 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 762948002705 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 762948002706 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 762948002707 homodimer interface [polypeptide binding]; other site 762948002708 NAD binding pocket [chemical binding]; other site 762948002709 ATP binding pocket [chemical binding]; other site 762948002710 Mg binding site [ion binding]; other site 762948002711 active-site loop [active] 762948002712 Tic20-like protein; Region: Tic20; pfam09685 762948002713 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 762948002714 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 762948002715 putative active site [active] 762948002716 catalytic triad [active] 762948002717 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 762948002718 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 762948002719 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 762948002720 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 762948002721 putative active site [active] 762948002722 catalytic triad [active] 762948002723 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 762948002724 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 762948002725 S-layer homology domain; Region: SLH; pfam00395 762948002726 S-layer homology domain; Region: SLH; pfam00395 762948002727 S-layer homology domain; Region: SLH; pfam00395 762948002728 Tic20-like protein; Region: Tic20; pfam09685 762948002729 Tic20-like protein; Region: Tic20; pfam09685 762948002730 Tic20-like protein; Region: Tic20; pfam09685 762948002731 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 762948002732 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 762948002733 GDP-binding site [chemical binding]; other site 762948002734 ACT binding site; other site 762948002735 IMP binding site; other site 762948002736 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 762948002737 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 762948002738 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 762948002739 oligomer interface [polypeptide binding]; other site 762948002740 metal binding site [ion binding]; metal-binding site 762948002741 metal binding site [ion binding]; metal-binding site 762948002742 putative Cl binding site [ion binding]; other site 762948002743 basic sphincter; other site 762948002744 hydrophobic gate; other site 762948002745 periplasmic entrance; other site 762948002746 Htaa; Region: HtaA; pfam04213 762948002747 S-layer homology domain; Region: SLH; pfam00395 762948002748 S-layer homology domain; Region: SLH; pfam00395 762948002749 S-layer homology domain; Region: SLH; pfam00395 762948002750 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 762948002751 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762948002752 ABC-ATPase subunit interface; other site 762948002753 dimer interface [polypeptide binding]; other site 762948002754 putative PBP binding regions; other site 762948002755 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 762948002756 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762948002757 ABC-ATPase subunit interface; other site 762948002758 dimer interface [polypeptide binding]; other site 762948002759 putative PBP binding regions; other site 762948002760 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 762948002761 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 762948002762 siderophore binding site; other site 762948002763 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 762948002764 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 762948002765 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 762948002766 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762948002767 homodimer interface [polypeptide binding]; other site 762948002768 substrate-cofactor binding pocket; other site 762948002769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948002770 catalytic residue [active] 762948002771 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 762948002772 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 762948002773 putative hydrophobic ligand binding site [chemical binding]; other site 762948002774 Predicted membrane protein [Function unknown]; Region: COG2860 762948002775 UPF0126 domain; Region: UPF0126; pfam03458 762948002776 UPF0126 domain; Region: UPF0126; pfam03458 762948002777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948002778 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 762948002779 putative substrate translocation pore; other site 762948002780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762948002781 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762948002782 Coenzyme A binding pocket [chemical binding]; other site 762948002783 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 762948002784 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 762948002785 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 762948002786 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 762948002787 dimer interface [polypeptide binding]; other site 762948002788 decamer (pentamer of dimers) interface [polypeptide binding]; other site 762948002789 catalytic triad [active] 762948002790 peroxidatic and resolving cysteines [active] 762948002791 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762948002792 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762948002793 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 762948002794 Acylphosphatase; Region: Acylphosphatase; cl00551 762948002795 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 762948002796 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762948002797 NAD(P) binding site [chemical binding]; other site 762948002798 putative active site [active] 762948002799 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 762948002800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948002801 putative substrate translocation pore; other site 762948002802 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762948002803 acetyl-CoA synthetase; Provisional; Region: PRK00174 762948002804 acyl-activating enzyme (AAE) consensus motif; other site 762948002805 AMP binding site [chemical binding]; other site 762948002806 active site 762948002807 CoA binding site [chemical binding]; other site 762948002808 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 762948002809 active site 762948002810 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 762948002811 active site 762948002812 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762948002813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762948002814 dimer interface [polypeptide binding]; other site 762948002815 conserved gate region; other site 762948002816 putative PBP binding loops; other site 762948002817 ABC-ATPase subunit interface; other site 762948002818 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 762948002819 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762948002820 substrate binding pocket [chemical binding]; other site 762948002821 membrane-bound complex binding site; other site 762948002822 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762948002823 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762948002824 Walker A/P-loop; other site 762948002825 ATP binding site [chemical binding]; other site 762948002826 Q-loop/lid; other site 762948002827 ABC transporter signature motif; other site 762948002828 Walker B; other site 762948002829 D-loop; other site 762948002830 H-loop/switch region; other site 762948002831 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 762948002832 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 762948002833 active site 762948002834 non-prolyl cis peptide bond; other site 762948002835 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 762948002836 hypothetical protein; Provisional; Region: PRK04233 762948002837 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 762948002838 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 762948002839 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 762948002840 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 762948002841 ferredoxin-NADP+ reductase; Region: PLN02852 762948002842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762948002843 potential frameshift: common BLAST hit: gi|116628412|ref|YP_821031.1| transposase 762948002844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 762948002845 Transposase; Region: DDE_Tnp_ISL3; pfam01610 762948002846 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 762948002847 Immunity protein Imm6; Region: Imm6; pfam14434 762948002848 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 762948002849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 762948002850 Transposase; Region: DDE_Tnp_ISL3; pfam01610 762948002851 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 762948002852 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762948002853 Walker A/P-loop; other site 762948002854 ATP binding site [chemical binding]; other site 762948002855 Q-loop/lid; other site 762948002856 ABC transporter signature motif; other site 762948002857 Walker B; other site 762948002858 D-loop; other site 762948002859 H-loop/switch region; other site 762948002860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762948002861 dimer interface [polypeptide binding]; other site 762948002862 conserved gate region; other site 762948002863 putative PBP binding loops; other site 762948002864 ABC-ATPase subunit interface; other site 762948002865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762948002866 ABC-ATPase subunit interface; other site 762948002867 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 762948002868 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762948002869 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 762948002870 Ca binding site [ion binding]; other site 762948002871 active site 762948002872 catalytic site [active] 762948002873 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 762948002874 Uncharacterized conserved protein [Function unknown]; Region: COG1359 762948002875 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 762948002876 RNA/DNA hybrid binding site [nucleotide binding]; other site 762948002877 active site 762948002878 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 762948002879 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 762948002880 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 762948002881 putative active site [active] 762948002882 catalytic site [active] 762948002883 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 762948002884 putative active site [active] 762948002885 catalytic site [active] 762948002886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948002887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948002888 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762948002889 putative substrate translocation pore; other site 762948002890 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_3; cd12160 762948002891 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762948002892 putative ligand binding site [chemical binding]; other site 762948002893 putative NAD binding site [chemical binding]; other site 762948002894 catalytic site [active] 762948002895 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762948002896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762948002897 putative PBP binding loops; other site 762948002898 dimer interface [polypeptide binding]; other site 762948002899 ABC-ATPase subunit interface; other site 762948002900 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762948002901 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 762948002902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762948002903 dimer interface [polypeptide binding]; other site 762948002904 conserved gate region; other site 762948002905 putative PBP binding loops; other site 762948002906 ABC-ATPase subunit interface; other site 762948002907 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 762948002908 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762948002909 Walker A/P-loop; other site 762948002910 ATP binding site [chemical binding]; other site 762948002911 Q-loop/lid; other site 762948002912 ABC transporter signature motif; other site 762948002913 Walker B; other site 762948002914 D-loop; other site 762948002915 H-loop/switch region; other site 762948002916 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762948002917 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762948002918 Walker A/P-loop; other site 762948002919 ATP binding site [chemical binding]; other site 762948002920 Q-loop/lid; other site 762948002921 ABC transporter signature motif; other site 762948002922 Walker B; other site 762948002923 D-loop; other site 762948002924 H-loop/switch region; other site 762948002925 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762948002926 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762948002927 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 762948002928 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762948002929 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 762948002930 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 762948002931 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762948002932 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 762948002933 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762948002934 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 762948002935 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 762948002936 active site turn [active] 762948002937 phosphorylation site [posttranslational modification] 762948002938 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 762948002939 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 762948002940 HPr interaction site; other site 762948002941 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762948002942 active site 762948002943 phosphorylation site [posttranslational modification] 762948002944 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 762948002945 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762948002946 Soluble P-type ATPase [General function prediction only]; Region: COG4087 762948002947 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 762948002948 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762948002949 Walker A/P-loop; other site 762948002950 ATP binding site [chemical binding]; other site 762948002951 Q-loop/lid; other site 762948002952 ABC transporter signature motif; other site 762948002953 Walker B; other site 762948002954 D-loop; other site 762948002955 H-loop/switch region; other site 762948002956 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 762948002957 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762948002958 dimer interface [polypeptide binding]; other site 762948002959 putative PBP binding regions; other site 762948002960 ABC-ATPase subunit interface; other site 762948002961 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 762948002962 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 762948002963 intersubunit interface [polypeptide binding]; other site 762948002964 Htaa; Region: HtaA; pfam04213 762948002965 Htaa; Region: HtaA; pfam04213 762948002966 Htaa; Region: HtaA; pfam04213 762948002967 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 762948002968 heme binding pocket [chemical binding]; other site 762948002969 heme ligand [chemical binding]; other site 762948002970 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 762948002971 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 762948002972 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 762948002973 dimerization interface [polypeptide binding]; other site 762948002974 ATP binding site [chemical binding]; other site 762948002975 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 762948002976 dimerization interface [polypeptide binding]; other site 762948002977 ATP binding site [chemical binding]; other site 762948002978 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 762948002979 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 762948002980 putative active site [active] 762948002981 catalytic triad [active] 762948002982 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 762948002983 aspartate kinase; Reviewed; Region: PRK06635 762948002984 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 762948002985 putative nucleotide binding site [chemical binding]; other site 762948002986 putative catalytic residues [active] 762948002987 putative Mg ion binding site [ion binding]; other site 762948002988 putative aspartate binding site [chemical binding]; other site 762948002989 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 762948002990 putative allosteric regulatory site; other site 762948002991 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 762948002992 putative allosteric regulatory residue; other site 762948002993 recombination protein RecR; Reviewed; Region: recR; PRK00076 762948002994 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 762948002995 RecR protein; Region: RecR; pfam02132 762948002996 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 762948002997 putative active site [active] 762948002998 putative metal-binding site [ion binding]; other site 762948002999 tetramer interface [polypeptide binding]; other site 762948003000 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 762948003001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762948003002 Walker A motif; other site 762948003003 ATP binding site [chemical binding]; other site 762948003004 Walker B motif; other site 762948003005 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 762948003006 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 762948003007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948003008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948003009 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 762948003010 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 762948003011 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 762948003012 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 762948003013 active site 762948003014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762948003015 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 762948003016 putative hydrophobic ligand binding site [chemical binding]; other site 762948003017 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 762948003018 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 762948003019 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 762948003020 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 762948003021 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762948003022 active site 762948003023 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948003024 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948003025 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 762948003026 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762948003027 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762948003028 ATP binding site [chemical binding]; other site 762948003029 putative Mg++ binding site [ion binding]; other site 762948003030 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 762948003031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762948003032 nucleotide binding region [chemical binding]; other site 762948003033 ATP-binding site [chemical binding]; other site 762948003034 DEAD/H associated; Region: DEAD_assoc; pfam08494 762948003035 malonic semialdehyde reductase; Provisional; Region: PRK05365 762948003036 FMN binding site [chemical binding]; other site 762948003037 dimer interface [polypeptide binding]; other site 762948003038 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 762948003039 FMN binding site [chemical binding]; other site 762948003040 dimer interface [polypeptide binding]; other site 762948003041 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 762948003042 FMN binding site [chemical binding]; other site 762948003043 dimer interface [polypeptide binding]; other site 762948003044 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 762948003045 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762948003046 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 762948003047 catalytic loop [active] 762948003048 iron binding site [ion binding]; other site 762948003049 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 762948003050 active site 762948003051 substrate-binding site [chemical binding]; other site 762948003052 metal-binding site [ion binding] 762948003053 GTP binding site [chemical binding]; other site 762948003054 Transcriptional regulator; Region: Rrf2; cl17282 762948003055 Rrf2 family protein; Region: rrf2_super; TIGR00738 762948003056 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 762948003057 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 762948003058 heme-binding site [chemical binding]; other site 762948003059 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 762948003060 FAD binding pocket [chemical binding]; other site 762948003061 FAD binding motif [chemical binding]; other site 762948003062 phosphate binding motif [ion binding]; other site 762948003063 beta-alpha-beta structure motif; other site 762948003064 NAD binding pocket [chemical binding]; other site 762948003065 Heme binding pocket [chemical binding]; other site 762948003066 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 762948003067 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 762948003068 active site 762948003069 substrate binding site [chemical binding]; other site 762948003070 metal binding site [ion binding]; metal-binding site 762948003071 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 762948003072 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 762948003073 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 762948003074 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762948003075 active site 762948003076 NTP binding site [chemical binding]; other site 762948003077 metal binding triad [ion binding]; metal-binding site 762948003078 antibiotic binding site [chemical binding]; other site 762948003079 Uncharacterized conserved protein [Function unknown]; Region: COG2361 762948003080 AAA domain; Region: AAA_33; pfam13671 762948003081 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 762948003082 active site 762948003083 metal binding site [ion binding]; metal-binding site 762948003084 RNA ligase; Region: RNA_lig_T4_1; pfam09511 762948003085 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 762948003086 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 762948003087 DNA polymerase III subunit delta'; Validated; Region: PRK07940 762948003088 DNA polymerase III subunit delta'; Validated; Region: PRK08485 762948003089 thymidylate kinase; Validated; Region: tmk; PRK00698 762948003090 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 762948003091 TMP-binding site; other site 762948003092 ATP-binding site [chemical binding]; other site 762948003093 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 762948003094 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762948003095 homodimer interface [polypeptide binding]; other site 762948003096 substrate-cofactor binding pocket; other site 762948003097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948003098 catalytic residue [active] 762948003099 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 762948003100 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762948003101 catalytic core [active] 762948003102 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 762948003103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762948003104 dimer interface [polypeptide binding]; other site 762948003105 phosphorylation site [posttranslational modification] 762948003106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762948003107 ATP binding site [chemical binding]; other site 762948003108 Mg2+ binding site [ion binding]; other site 762948003109 G-X-G motif; other site 762948003110 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762948003111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762948003112 active site 762948003113 phosphorylation site [posttranslational modification] 762948003114 intermolecular recognition site; other site 762948003115 dimerization interface [polypeptide binding]; other site 762948003116 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762948003117 DNA binding site [nucleotide binding] 762948003118 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 762948003119 substrate binding site; other site 762948003120 dimer interface; other site 762948003121 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 762948003122 homotrimer interaction site [polypeptide binding]; other site 762948003123 zinc binding site [ion binding]; other site 762948003124 CDP-binding sites; other site 762948003125 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 762948003126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762948003127 active site 762948003128 HIGH motif; other site 762948003129 nucleotide binding site [chemical binding]; other site 762948003130 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 762948003131 KMSKS motif; other site 762948003132 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762948003133 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 762948003134 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 762948003135 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762948003136 Thioredoxin; Region: Thioredoxin_4; cl17273 762948003137 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 762948003138 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 762948003139 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 762948003140 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762948003141 Walker A/P-loop; other site 762948003142 ATP binding site [chemical binding]; other site 762948003143 Q-loop/lid; other site 762948003144 ABC transporter signature motif; other site 762948003145 Walker B; other site 762948003146 D-loop; other site 762948003147 H-loop/switch region; other site 762948003148 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 762948003149 active site 762948003150 catalytic triad [active] 762948003151 oxyanion hole [active] 762948003152 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 762948003153 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 762948003154 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 762948003155 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 762948003156 IHF - DNA interface [nucleotide binding]; other site 762948003157 IHF dimer interface [polypeptide binding]; other site 762948003158 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 762948003159 CopC domain; Region: CopC; pfam04234 762948003160 Protein of unknown function (DUF461); Region: DUF461; pfam04314 762948003161 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 762948003162 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 762948003163 Copper resistance protein D; Region: CopD; cl00563 762948003164 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 762948003165 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 762948003166 DNA-binding interface [nucleotide binding]; DNA binding site 762948003167 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 762948003168 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 762948003169 active site 762948003170 substrate binding site [chemical binding]; other site 762948003171 FMN binding site [chemical binding]; other site 762948003172 putative catalytic residues [active] 762948003173 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762948003174 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762948003175 Methyltransferase domain; Region: Methyltransf_31; pfam13847 762948003176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948003177 S-adenosylmethionine binding site [chemical binding]; other site 762948003178 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 762948003179 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762948003180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948003181 putative substrate translocation pore; other site 762948003182 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948003183 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948003184 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762948003185 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 762948003186 NAD(P) binding site [chemical binding]; other site 762948003187 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 762948003188 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 762948003189 ATP binding site [chemical binding]; other site 762948003190 substrate interface [chemical binding]; other site 762948003191 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762948003192 active site residue [active] 762948003193 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 762948003194 ThiS interaction site; other site 762948003195 putative active site [active] 762948003196 tetramer interface [polypeptide binding]; other site 762948003197 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 762948003198 thiS-thiF/thiG interaction site; other site 762948003199 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 762948003200 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 762948003201 thiamine phosphate binding site [chemical binding]; other site 762948003202 active site 762948003203 pyrophosphate binding site [ion binding]; other site 762948003204 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 762948003205 trimer interface [polypeptide binding]; other site 762948003206 active site 762948003207 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 762948003208 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 762948003209 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 762948003210 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 762948003211 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 762948003212 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762948003213 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762948003214 Walker A/P-loop; other site 762948003215 ATP binding site [chemical binding]; other site 762948003216 Q-loop/lid; other site 762948003217 ABC transporter signature motif; other site 762948003218 Walker B; other site 762948003219 D-loop; other site 762948003220 H-loop/switch region; other site 762948003221 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762948003222 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 762948003223 Walker A/P-loop; other site 762948003224 ATP binding site [chemical binding]; other site 762948003225 Q-loop/lid; other site 762948003226 ABC transporter signature motif; other site 762948003227 Walker B; other site 762948003228 D-loop; other site 762948003229 H-loop/switch region; other site 762948003230 Cobalt transport protein; Region: CbiQ; cl00463 762948003231 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 762948003232 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 762948003233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948003234 catalytic residue [active] 762948003235 phosphofructokinase family protein; Provisional; Region: PTZ00468 762948003236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948003237 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 762948003238 putative substrate translocation pore; other site 762948003239 hypothetical protein; Provisional; Region: PRK06547 762948003240 Low molecular weight phosphatase family; Region: LMWPc; cd00115 762948003241 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 762948003242 active site 762948003243 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 762948003244 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 762948003245 Tumour suppressor, Mitostatin; Region: Trichoplein; pfam13868 762948003246 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762948003247 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 762948003248 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762948003249 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762948003250 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 762948003251 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 762948003252 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 762948003253 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 762948003254 nucleotide binding site [chemical binding]; other site 762948003255 GrpE; Region: GrpE; pfam01025 762948003256 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 762948003257 dimer interface [polypeptide binding]; other site 762948003258 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 762948003259 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 762948003260 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 762948003261 HSP70 interaction site [polypeptide binding]; other site 762948003262 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 762948003263 substrate binding site [polypeptide binding]; other site 762948003264 dimer interface [polypeptide binding]; other site 762948003265 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 762948003266 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 762948003267 DNA binding residues [nucleotide binding] 762948003268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948003269 S-adenosylmethionine binding site [chemical binding]; other site 762948003270 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 762948003271 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 762948003272 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 762948003273 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 762948003274 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 762948003275 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 762948003276 RNA binding site [nucleotide binding]; other site 762948003277 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762948003278 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762948003279 active site 762948003280 catalytic tetrad [active] 762948003281 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 762948003282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762948003283 ATP binding site [chemical binding]; other site 762948003284 putative Mg++ binding site [ion binding]; other site 762948003285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762948003286 nucleotide binding region [chemical binding]; other site 762948003287 ATP-binding site [chemical binding]; other site 762948003288 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 762948003289 oligomeric interface; other site 762948003290 putative active site [active] 762948003291 homodimer interface [polypeptide binding]; other site 762948003292 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 762948003293 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 762948003294 active site 762948003295 substrate binding site [chemical binding]; other site 762948003296 cosubstrate binding site; other site 762948003297 catalytic site [active] 762948003298 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 762948003299 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 762948003300 purine monophosphate binding site [chemical binding]; other site 762948003301 dimer interface [polypeptide binding]; other site 762948003302 putative catalytic residues [active] 762948003303 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 762948003304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948003305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948003306 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 762948003307 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 762948003308 dimer interface [polypeptide binding]; other site 762948003309 active site 762948003310 glycine-pyridoxal phosphate binding site [chemical binding]; other site 762948003311 folate binding site [chemical binding]; other site 762948003312 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 762948003313 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 762948003314 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 762948003315 homodimer interface [polypeptide binding]; other site 762948003316 NADP binding site [chemical binding]; other site 762948003317 substrate binding site [chemical binding]; other site 762948003318 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762948003319 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762948003320 DNA-binding site [nucleotide binding]; DNA binding site 762948003321 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 762948003322 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 762948003323 putative active site [active] 762948003324 putative catalytic site [active] 762948003325 putative DNA binding site [nucleotide binding]; other site 762948003326 putative phosphate binding site [ion binding]; other site 762948003327 metal binding site A [ion binding]; metal-binding site 762948003328 putative AP binding site [nucleotide binding]; other site 762948003329 putative metal binding site B [ion binding]; other site 762948003330 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 762948003331 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 762948003332 active site 762948003333 HIGH motif; other site 762948003334 dimer interface [polypeptide binding]; other site 762948003335 KMSKS motif; other site 762948003336 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 762948003337 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 762948003338 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 762948003339 Substrate binding site; other site 762948003340 Cupin domain; Region: Cupin_2; cl17218 762948003341 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 762948003342 putative Iron-sulfur protein interface [polypeptide binding]; other site 762948003343 putative proximal heme binding site [chemical binding]; other site 762948003344 putative SdhD-like interface [polypeptide binding]; other site 762948003345 putative distal heme binding site [chemical binding]; other site 762948003346 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 762948003347 putative Iron-sulfur protein interface [polypeptide binding]; other site 762948003348 putative proximal heme binding site [chemical binding]; other site 762948003349 putative SdhC-like subunit interface [polypeptide binding]; other site 762948003350 putative distal heme binding site [chemical binding]; other site 762948003351 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 762948003352 L-aspartate oxidase; Provisional; Region: PRK06175 762948003353 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 762948003354 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 762948003355 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 762948003356 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762948003357 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 762948003358 metal binding site [ion binding]; metal-binding site 762948003359 putative dimer interface [polypeptide binding]; other site 762948003360 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 762948003361 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 762948003362 homodimer interface [polypeptide binding]; other site 762948003363 metal binding site [ion binding]; metal-binding site 762948003364 enolase; Provisional; Region: eno; PRK00077 762948003365 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 762948003366 dimer interface [polypeptide binding]; other site 762948003367 metal binding site [ion binding]; metal-binding site 762948003368 substrate binding pocket [chemical binding]; other site 762948003369 Septum formation initiator; Region: DivIC; pfam04977 762948003370 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 762948003371 potential frameshift: common BLAST hit: gi|119962077|ref|YP_947049.1| protein of unknown function (DUF501) 762948003372 Protein of unknown function (DUF501); Region: DUF501; cl00652 762948003373 Protein of unknown function (DUF501); Region: DUF501; cl00652 762948003374 exopolyphosphatase; Region: exo_poly_only; TIGR03706 762948003375 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762948003376 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 762948003377 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 762948003378 active site 762948003379 catalytic residues [active] 762948003380 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 762948003381 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762948003382 Predicted membrane protein [Function unknown]; Region: COG2259 762948003383 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 762948003384 Excalibur calcium-binding domain; Region: Excalibur; smart00894 762948003385 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762948003386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762948003387 active site 762948003388 motif I; other site 762948003389 motif II; other site 762948003390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762948003391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762948003392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948003393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948003394 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762948003395 putative substrate translocation pore; other site 762948003396 Bax inhibitor 1 like; Region: BaxI_1; cl17691 762948003397 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762948003398 Domain of unknown function DUF20; Region: UPF0118; pfam01594 762948003399 threonine dehydratase; Provisional; Region: PRK08198 762948003400 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 762948003401 tetramer interface [polypeptide binding]; other site 762948003402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948003403 catalytic residue [active] 762948003404 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 762948003405 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 762948003406 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 762948003407 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 762948003408 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 762948003409 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 762948003410 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 762948003411 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 762948003412 catalytic residue [active] 762948003413 putative FPP diphosphate binding site; other site 762948003414 putative FPP binding hydrophobic cleft; other site 762948003415 dimer interface [polypeptide binding]; other site 762948003416 putative IPP diphosphate binding site; other site 762948003417 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 762948003418 nudix motif; other site 762948003419 S-layer homology domain; Region: SLH; pfam00395 762948003420 S-layer homology domain; Region: SLH; pfam00395 762948003421 fumarate hydratase; Reviewed; Region: fumC; PRK00485 762948003422 Class II fumarases; Region: Fumarase_classII; cd01362 762948003423 active site 762948003424 tetramer interface [polypeptide binding]; other site 762948003425 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 762948003426 active site clefts [active] 762948003427 zinc binding site [ion binding]; other site 762948003428 dimer interface [polypeptide binding]; other site 762948003429 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 762948003430 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 762948003431 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 762948003432 putative active site [active] 762948003433 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 762948003434 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 762948003435 AIR carboxylase; Region: AIRC; pfam00731 762948003436 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 762948003437 ATP-grasp domain; Region: ATP-grasp; pfam02222 762948003438 Predicted membrane protein [Function unknown]; Region: COG2246 762948003439 GtrA-like protein; Region: GtrA; pfam04138 762948003440 TIGR03089 family protein; Region: TIGR03089 762948003441 Transcription factor WhiB; Region: Whib; pfam02467 762948003442 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 762948003443 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 762948003444 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 762948003445 Predicted methyltransferases [General function prediction only]; Region: COG0313 762948003446 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 762948003447 putative SAM binding site [chemical binding]; other site 762948003448 putative homodimer interface [polypeptide binding]; other site 762948003449 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 762948003450 active site 762948003451 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 762948003452 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 762948003453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948003454 S-adenosylmethionine binding site [chemical binding]; other site 762948003455 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 762948003456 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762948003457 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762948003458 active site 762948003459 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 762948003460 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 762948003461 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 762948003462 trimer interface [polypeptide binding]; other site 762948003463 active site 762948003464 substrate binding site [chemical binding]; other site 762948003465 CoA binding site [chemical binding]; other site 762948003466 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 762948003467 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762948003468 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762948003469 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762948003470 ABC transporter; Region: ABC_tran_2; pfam12848 762948003471 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762948003472 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 762948003473 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 762948003474 Substrate binding site; other site 762948003475 Mg++ binding site; other site 762948003476 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 762948003477 active site 762948003478 substrate binding site [chemical binding]; other site 762948003479 CoA binding site [chemical binding]; other site 762948003480 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 762948003481 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 762948003482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762948003483 active site 762948003484 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 762948003485 Low molecular weight phosphatase family; Region: LMWPc; cl00105 762948003486 active site 762948003487 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 762948003488 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 762948003489 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762948003490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948003491 Walker A/P-loop; other site 762948003492 ATP binding site [chemical binding]; other site 762948003493 Q-loop/lid; other site 762948003494 ABC transporter signature motif; other site 762948003495 Walker B; other site 762948003496 D-loop; other site 762948003497 H-loop/switch region; other site 762948003498 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762948003499 active site 762948003500 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 762948003501 GDP-Fucose binding site [chemical binding]; other site 762948003502 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762948003503 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762948003504 active site 762948003505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 762948003506 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 762948003507 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 762948003508 ligand binding site; other site 762948003509 tetramer interface; other site 762948003510 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 762948003511 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 762948003512 NeuB family; Region: NeuB; pfam03102 762948003513 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 762948003514 NeuB binding interface [polypeptide binding]; other site 762948003515 putative substrate binding site [chemical binding]; other site 762948003516 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 762948003517 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 762948003518 Acyltransferase family; Region: Acyl_transf_3; pfam01757 762948003519 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762948003520 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 762948003521 putative ADP-binding pocket [chemical binding]; other site 762948003522 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 762948003523 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762948003524 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762948003525 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 762948003526 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762948003527 active site 762948003528 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 762948003529 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 762948003530 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762948003531 putative ADP-binding pocket [chemical binding]; other site 762948003532 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 762948003533 Chain length determinant protein; Region: Wzz; cl15801 762948003534 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 762948003535 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762948003536 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 762948003537 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 762948003538 substrate binding site; other site 762948003539 tetramer interface; other site 762948003540 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 762948003541 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 762948003542 NAD binding site [chemical binding]; other site 762948003543 substrate binding site [chemical binding]; other site 762948003544 homodimer interface [polypeptide binding]; other site 762948003545 active site 762948003546 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 762948003547 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 762948003548 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 762948003549 NADP binding site [chemical binding]; other site 762948003550 active site 762948003551 putative substrate binding site [chemical binding]; other site 762948003552 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 762948003553 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 762948003554 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762948003555 NAD(P) binding site [chemical binding]; other site 762948003556 catalytic residues [active] 762948003557 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 762948003558 5S rRNA interface [nucleotide binding]; other site 762948003559 CTC domain interface [polypeptide binding]; other site 762948003560 L16 interface [polypeptide binding]; other site 762948003561 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 762948003562 putative active site [active] 762948003563 catalytic residue [active] 762948003564 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 762948003565 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 762948003566 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762948003567 catalytic residue [active] 762948003568 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 762948003569 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 762948003570 trimerization site [polypeptide binding]; other site 762948003571 active site 762948003572 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 762948003573 RHS Repeat; Region: RHS_repeat; pfam05593 762948003574 RHS Repeat; Region: RHS_repeat; pfam05593 762948003575 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 762948003576 RHS Repeat; Region: RHS_repeat; pfam05593 762948003577 RHS Repeat; Region: RHS_repeat; cl11982 762948003578 RHS Repeat; Region: RHS_repeat; pfam05593 762948003579 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 762948003580 RHS Repeat; Region: RHS_repeat; pfam05593 762948003581 RHS Repeat; Region: RHS_repeat; pfam05593 762948003582 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 762948003583 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 762948003584 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762948003585 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 762948003586 active site 762948003587 nucleotide binding site [chemical binding]; other site 762948003588 HIGH motif; other site 762948003589 KMSKS motif; other site 762948003590 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 762948003591 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 762948003592 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 762948003593 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 762948003594 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 762948003595 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 762948003596 Chain length determinant protein; Region: Wzz; cl15801 762948003597 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 762948003598 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762948003599 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762948003600 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 762948003601 active site 762948003602 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 762948003603 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 762948003604 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 762948003605 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 762948003606 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762948003607 ATP binding site [chemical binding]; other site 762948003608 putative Mg++ binding site [ion binding]; other site 762948003609 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762948003610 nucleotide binding region [chemical binding]; other site 762948003611 ATP-binding site [chemical binding]; other site 762948003612 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 762948003613 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 762948003614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762948003615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762948003616 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762948003617 metabolite-proton symporter; Region: 2A0106; TIGR00883 762948003618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948003619 putative substrate translocation pore; other site 762948003620 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 762948003621 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762948003622 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 762948003623 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 762948003624 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 762948003625 carboxyltransferase (CT) interaction site; other site 762948003626 biotinylation site [posttranslational modification]; other site 762948003627 Maf-like protein; Region: Maf; pfam02545 762948003628 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 762948003629 active site 762948003630 dimer interface [polypeptide binding]; other site 762948003631 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 762948003632 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 762948003633 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 762948003634 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 762948003635 Restriction endonuclease; Region: Mrr_cat; pfam04471 762948003636 Restriction endonuclease; Region: Mrr_cat; pfam04471 762948003637 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 762948003638 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 762948003639 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 762948003640 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 762948003641 YCII-related domain; Region: YCII; cl00999 762948003642 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 762948003643 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 762948003644 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 762948003645 Bacterial PH domain; Region: DUF304; pfam03703 762948003646 cyclase homology domain; Region: CHD; cd07302 762948003647 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 762948003648 nucleotidyl binding site; other site 762948003649 metal binding site [ion binding]; metal-binding site 762948003650 dimer interface [polypeptide binding]; other site 762948003651 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 762948003652 active site 762948003653 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 762948003654 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 762948003655 nucleotide binding pocket [chemical binding]; other site 762948003656 K-X-D-G motif; other site 762948003657 catalytic site [active] 762948003658 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 762948003659 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 762948003660 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 762948003661 Dimer interface [polypeptide binding]; other site 762948003662 BRCT sequence motif; other site 762948003663 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 762948003664 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762948003665 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 762948003666 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762948003667 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 762948003668 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 762948003669 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 762948003670 GatB domain; Region: GatB_Yqey; smart00845 762948003671 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762948003672 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762948003673 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 762948003674 Walker A/P-loop; other site 762948003675 ATP binding site [chemical binding]; other site 762948003676 Q-loop/lid; other site 762948003677 ABC transporter signature motif; other site 762948003678 Walker B; other site 762948003679 D-loop; other site 762948003680 H-loop/switch region; other site 762948003681 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 762948003682 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762948003683 Abi-like protein; Region: Abi_2; pfam07751 762948003684 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 762948003685 classical (c) SDRs; Region: SDR_c; cd05233 762948003686 NAD(P) binding site [chemical binding]; other site 762948003687 active site 762948003688 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 762948003689 putative hydrophobic ligand binding site [chemical binding]; other site 762948003690 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762948003691 dimerization interface [polypeptide binding]; other site 762948003692 putative DNA binding site [nucleotide binding]; other site 762948003693 putative Zn2+ binding site [ion binding]; other site 762948003694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948003695 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 762948003696 Walker A/P-loop; other site 762948003697 ATP binding site [chemical binding]; other site 762948003698 Q-loop/lid; other site 762948003699 ABC transporter signature motif; other site 762948003700 Walker B; other site 762948003701 D-loop; other site 762948003702 H-loop/switch region; other site 762948003703 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 762948003704 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762948003705 homodimer interface [polypeptide binding]; other site 762948003706 substrate-cofactor binding pocket; other site 762948003707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948003708 catalytic residue [active] 762948003709 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 762948003710 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 762948003711 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 762948003712 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 762948003713 DNA binding residues [nucleotide binding] 762948003714 dimer interface [polypeptide binding]; other site 762948003715 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 762948003716 Predicted esterase [General function prediction only]; Region: COG0400 762948003717 Serine hydrolase (FSH1); Region: FSH1; pfam03959 762948003718 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762948003719 RNA binding surface [nucleotide binding]; other site 762948003720 glycyl-tRNA synthetase; Provisional; Region: PRK04173 762948003721 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762948003722 motif 1; other site 762948003723 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 762948003724 active site 762948003725 motif 2; other site 762948003726 motif 3; other site 762948003727 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 762948003728 anticodon binding site; other site 762948003729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762948003730 Coenzyme A binding pocket [chemical binding]; other site 762948003731 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 762948003732 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 762948003733 FMN binding site [chemical binding]; other site 762948003734 active site 762948003735 catalytic residues [active] 762948003736 substrate binding site [chemical binding]; other site 762948003737 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 762948003738 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762948003739 Zn2+ binding site [ion binding]; other site 762948003740 Mg2+ binding site [ion binding]; other site 762948003741 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 762948003742 DNA primase, catalytic core; Region: dnaG; TIGR01391 762948003743 CHC2 zinc finger; Region: zf-CHC2; pfam01807 762948003744 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 762948003745 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 762948003746 active site 762948003747 metal binding site [ion binding]; metal-binding site 762948003748 interdomain interaction site; other site 762948003749 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 762948003750 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762948003751 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 762948003752 putative ADP-binding pocket [chemical binding]; other site 762948003753 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 762948003754 Peptidase family M23; Region: Peptidase_M23; pfam01551 762948003755 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 762948003756 rRNA interaction site [nucleotide binding]; other site 762948003757 S8 interaction site; other site 762948003758 putative laminin-1 binding site; other site 762948003759 elongation factor Ts; Provisional; Region: tsf; PRK09377 762948003760 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 762948003761 Elongation factor TS; Region: EF_TS; pfam00889 762948003762 Elongation factor TS; Region: EF_TS; pfam00889 762948003763 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 762948003764 putative nucleotide binding site [chemical binding]; other site 762948003765 uridine monophosphate binding site [chemical binding]; other site 762948003766 homohexameric interface [polypeptide binding]; other site 762948003767 ribosome recycling factor; Reviewed; Region: frr; PRK00083 762948003768 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 762948003769 hinge region; other site 762948003770 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 762948003771 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 762948003772 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 762948003773 DivIVA domain; Region: DivI1A_domain; TIGR03544 762948003774 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 762948003775 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 762948003776 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 762948003777 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 762948003778 RIP metalloprotease RseP; Region: TIGR00054 762948003779 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 762948003780 active site 762948003781 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 762948003782 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 762948003783 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 762948003784 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 762948003785 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 762948003786 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 762948003787 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 762948003788 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762948003789 prolyl-tRNA synthetase; Provisional; Region: PRK09194 762948003790 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 762948003791 dimer interface [polypeptide binding]; other site 762948003792 motif 1; other site 762948003793 active site 762948003794 motif 2; other site 762948003795 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 762948003796 putative deacylase active site [active] 762948003797 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762948003798 active site 762948003799 motif 3; other site 762948003800 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 762948003801 anticodon binding site; other site 762948003802 ribosome maturation protein RimP; Reviewed; Region: PRK00092 762948003803 Sm and related proteins; Region: Sm_like; cl00259 762948003804 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 762948003805 NusA N-terminal domain; Region: NusA_N; pfam08529 762948003806 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 762948003807 RNA binding site [nucleotide binding]; other site 762948003808 homodimer interface [polypeptide binding]; other site 762948003809 NusA-like KH domain; Region: KH_5; pfam13184 762948003810 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 762948003811 G-X-X-G motif; other site 762948003812 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 762948003813 putative RNA binding cleft [nucleotide binding]; other site 762948003814 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 762948003815 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 762948003816 translation initiation factor IF-2; Region: IF-2; TIGR00487 762948003817 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 762948003818 G1 box; other site 762948003819 putative GEF interaction site [polypeptide binding]; other site 762948003820 GTP/Mg2+ binding site [chemical binding]; other site 762948003821 Switch I region; other site 762948003822 G2 box; other site 762948003823 G3 box; other site 762948003824 Switch II region; other site 762948003825 G4 box; other site 762948003826 G5 box; other site 762948003827 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 762948003828 Translation-initiation factor 2; Region: IF-2; pfam11987 762948003829 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 762948003830 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 762948003831 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 762948003832 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 762948003833 RNA binding site [nucleotide binding]; other site 762948003834 active site 762948003835 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 762948003836 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 762948003837 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 762948003838 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 762948003839 active site 762948003840 Riboflavin kinase; Region: Flavokinase; smart00904 762948003841 S-ribosylhomocysteinase; Provisional; Region: PRK02260 762948003842 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 762948003843 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 762948003844 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 762948003845 Spore germination protein; Region: Spore_permease; cl17796 762948003846 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 762948003847 16S/18S rRNA binding site [nucleotide binding]; other site 762948003848 S13e-L30e interaction site [polypeptide binding]; other site 762948003849 25S rRNA binding site [nucleotide binding]; other site 762948003850 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 762948003851 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 762948003852 oligomer interface [polypeptide binding]; other site 762948003853 RNA binding site [nucleotide binding]; other site 762948003854 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 762948003855 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 762948003856 RNase E interface [polypeptide binding]; other site 762948003857 trimer interface [polypeptide binding]; other site 762948003858 active site 762948003859 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 762948003860 putative nucleic acid binding region [nucleotide binding]; other site 762948003861 G-X-X-G motif; other site 762948003862 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 762948003863 RNA binding site [nucleotide binding]; other site 762948003864 domain interface; other site 762948003865 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762948003866 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 762948003867 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762948003868 Epoxide hydrolase N terminus; Region: EHN; pfam06441 762948003869 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762948003870 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 762948003871 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 762948003872 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 762948003873 active site 762948003874 catalytic triad [active] 762948003875 oxyanion hole [active] 762948003876 dihydrodipicolinate reductase; Provisional; Region: PRK00048 762948003877 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 762948003878 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 762948003879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 762948003880 TPR motif; other site 762948003881 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762948003882 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 762948003883 dimer interface [polypeptide binding]; other site 762948003884 active site 762948003885 catalytic residue [active] 762948003886 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 762948003887 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762948003888 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 762948003889 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 762948003890 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 762948003891 G1 box; other site 762948003892 GTP/Mg2+ binding site [chemical binding]; other site 762948003893 G2 box; other site 762948003894 Switch I region; other site 762948003895 G3 box; other site 762948003896 Switch II region; other site 762948003897 G4 box; other site 762948003898 G5 box; other site 762948003899 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 762948003900 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 762948003901 Competence-damaged protein; Region: CinA; pfam02464 762948003902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762948003903 non-specific DNA binding site [nucleotide binding]; other site 762948003904 salt bridge; other site 762948003905 sequence-specific DNA binding site [nucleotide binding]; other site 762948003906 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 762948003907 recombinase A; Provisional; Region: recA; PRK09354 762948003908 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 762948003909 hexamer interface [polypeptide binding]; other site 762948003910 Walker A motif; other site 762948003911 ATP binding site [chemical binding]; other site 762948003912 Walker B motif; other site 762948003913 recombination regulator RecX; Reviewed; Region: recX; PRK00117 762948003914 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 762948003915 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 762948003916 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 762948003917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762948003918 FeS/SAM binding site; other site 762948003919 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 762948003920 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 762948003921 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 762948003922 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 762948003923 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 762948003924 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 762948003925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948003926 S-adenosylmethionine binding site [chemical binding]; other site 762948003927 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 762948003928 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 762948003929 HflX GTPase family; Region: HflX; cd01878 762948003930 G1 box; other site 762948003931 GTP/Mg2+ binding site [chemical binding]; other site 762948003932 Switch I region; other site 762948003933 G2 box; other site 762948003934 G3 box; other site 762948003935 Switch II region; other site 762948003936 G4 box; other site 762948003937 G5 box; other site 762948003938 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 762948003939 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 762948003940 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 762948003941 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762948003942 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762948003943 active site 762948003944 LexA repressor; Validated; Region: PRK00215 762948003945 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 762948003946 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 762948003947 Catalytic site [active] 762948003948 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762948003949 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 762948003950 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762948003951 conserved cys residue [active] 762948003952 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 762948003953 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 762948003954 catalytic residues [active] 762948003955 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 762948003956 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 762948003957 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 762948003958 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 762948003959 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 762948003960 23S rRNA binding site [nucleotide binding]; other site 762948003961 L21 binding site [polypeptide binding]; other site 762948003962 L13 binding site [polypeptide binding]; other site 762948003963 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 762948003964 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 762948003965 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762948003966 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 762948003967 Cation efflux family; Region: Cation_efflux; pfam01545 762948003968 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 762948003969 active site 762948003970 8-oxo-dGMP binding site [chemical binding]; other site 762948003971 nudix motif; other site 762948003972 metal binding site [ion binding]; metal-binding site 762948003973 Iron permease FTR1 family; Region: FTR1; pfam03239 762948003974 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 762948003975 Imelysin; Region: Peptidase_M75; pfam09375 762948003976 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 762948003977 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 762948003978 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 762948003979 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 762948003980 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 762948003981 dimer interface [polypeptide binding]; other site 762948003982 motif 1; other site 762948003983 active site 762948003984 motif 2; other site 762948003985 motif 3; other site 762948003986 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 762948003987 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 762948003988 putative tRNA-binding site [nucleotide binding]; other site 762948003989 B3/4 domain; Region: B3_4; pfam03483 762948003990 tRNA synthetase B5 domain; Region: B5; smart00874 762948003991 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 762948003992 dimer interface [polypeptide binding]; other site 762948003993 motif 1; other site 762948003994 motif 3; other site 762948003995 motif 2; other site 762948003996 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 762948003997 arginine repressor; Provisional; Region: PRK03341 762948003998 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 762948003999 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 762948004000 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 762948004001 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 762948004002 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 762948004003 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 762948004004 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 762948004005 acyl-activating enzyme (AAE) consensus motif; other site 762948004006 putative AMP binding site [chemical binding]; other site 762948004007 putative active site [active] 762948004008 putative CoA binding site [chemical binding]; other site 762948004009 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762948004010 active site 762948004011 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 762948004012 Part of AAA domain; Region: AAA_19; pfam13245 762948004013 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 762948004014 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 762948004015 active site 762948004016 HIGH motif; other site 762948004017 dimer interface [polypeptide binding]; other site 762948004018 KMSKS motif; other site 762948004019 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762948004020 RNA binding surface [nucleotide binding]; other site 762948004021 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 762948004022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762948004023 active site 762948004024 motif I; other site 762948004025 motif II; other site 762948004026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762948004027 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 762948004028 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762948004029 RNA binding surface [nucleotide binding]; other site 762948004030 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 762948004031 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 762948004032 ATP-NAD kinase; Region: NAD_kinase; pfam01513 762948004033 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 762948004034 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 762948004035 Walker A/P-loop; other site 762948004036 ATP binding site [chemical binding]; other site 762948004037 Q-loop/lid; other site 762948004038 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 762948004039 ABC transporter signature motif; other site 762948004040 Walker B; other site 762948004041 D-loop; other site 762948004042 H-loop/switch region; other site 762948004043 CTP synthetase; Validated; Region: pyrG; PRK05380 762948004044 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 762948004045 Catalytic site [active] 762948004046 active site 762948004047 UTP binding site [chemical binding]; other site 762948004048 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 762948004049 active site 762948004050 putative oxyanion hole; other site 762948004051 catalytic triad [active] 762948004052 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 762948004053 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 762948004054 dimer interface [polypeptide binding]; other site 762948004055 ADP-ribose binding site [chemical binding]; other site 762948004056 active site 762948004057 nudix motif; other site 762948004058 metal binding site [ion binding]; metal-binding site 762948004059 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 762948004060 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762948004061 active site 762948004062 DNA binding site [nucleotide binding] 762948004063 Int/Topo IB signature motif; other site 762948004064 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 762948004065 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 762948004066 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762948004067 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762948004068 P-loop; other site 762948004069 Magnesium ion binding site [ion binding]; other site 762948004070 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762948004071 Magnesium ion binding site [ion binding]; other site 762948004072 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 762948004073 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 762948004074 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 762948004075 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762948004076 RNA binding surface [nucleotide binding]; other site 762948004077 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 762948004078 active site 762948004079 prephenate dehydrogenase; Validated; Region: PRK06545 762948004080 prephenate dehydrogenase; Validated; Region: PRK08507 762948004081 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 762948004082 cytidylate kinase; Provisional; Region: cmk; PRK00023 762948004083 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 762948004084 CMP-binding site; other site 762948004085 The sites determining sugar specificity; other site 762948004086 GTP-binding protein Der; Reviewed; Region: PRK03003 762948004087 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 762948004088 G1 box; other site 762948004089 GTP/Mg2+ binding site [chemical binding]; other site 762948004090 Switch I region; other site 762948004091 G2 box; other site 762948004092 Switch II region; other site 762948004093 G3 box; other site 762948004094 G4 box; other site 762948004095 G5 box; other site 762948004096 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 762948004097 G1 box; other site 762948004098 GTP/Mg2+ binding site [chemical binding]; other site 762948004099 Switch I region; other site 762948004100 G2 box; other site 762948004101 G3 box; other site 762948004102 Switch II region; other site 762948004103 G4 box; other site 762948004104 G5 box; other site 762948004105 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 762948004106 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762948004107 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 762948004108 L-lactate permease; Region: Lactate_perm; cl00701 762948004109 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 762948004110 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 762948004111 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 762948004112 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762948004113 DNA binding site [nucleotide binding] 762948004114 active site 762948004115 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762948004116 minor groove reading motif; other site 762948004117 helix-hairpin-helix signature motif; other site 762948004118 glycerol kinase; Provisional; Region: glpK; PRK00047 762948004119 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 762948004120 N- and C-terminal domain interface [polypeptide binding]; other site 762948004121 active site 762948004122 MgATP binding site [chemical binding]; other site 762948004123 catalytic site [active] 762948004124 metal binding site [ion binding]; metal-binding site 762948004125 putative homotetramer interface [polypeptide binding]; other site 762948004126 glycerol binding site [chemical binding]; other site 762948004127 homodimer interface [polypeptide binding]; other site 762948004128 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 762948004129 amphipathic channel; other site 762948004130 Asn-Pro-Ala signature motifs; other site 762948004131 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 762948004132 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 762948004133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762948004134 DNA binding residues [nucleotide binding] 762948004135 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 762948004136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762948004137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762948004138 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 762948004139 putative dimerization interface [polypeptide binding]; other site 762948004140 Proline dehydrogenase; Region: Pro_dh; cl03282 762948004141 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 762948004142 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762948004143 NAD(P) binding site [chemical binding]; other site 762948004144 catalytic residues [active] 762948004145 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 762948004146 lipoyl attachment site [posttranslational modification]; other site 762948004147 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 762948004148 DNA binding residues [nucleotide binding] 762948004149 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 762948004150 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 762948004151 DNA binding residues [nucleotide binding] 762948004152 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 762948004153 putative dimer interface [polypeptide binding]; other site 762948004154 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762948004155 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762948004156 P-loop; other site 762948004157 Magnesium ion binding site [ion binding]; other site 762948004158 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762948004159 Magnesium ion binding site [ion binding]; other site 762948004160 mycothione reductase; Reviewed; Region: PRK07846 762948004161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762948004162 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762948004163 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 762948004164 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 762948004165 acyl-activating enzyme (AAE) consensus motif; other site 762948004166 putative AMP binding site [chemical binding]; other site 762948004167 putative active site [active] 762948004168 putative CoA binding site [chemical binding]; other site 762948004169 Esterase/lipase [General function prediction only]; Region: COG1647 762948004170 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 762948004171 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762948004172 putative acyl-acceptor binding pocket; other site 762948004173 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 762948004174 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 762948004175 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 762948004176 active site 762948004177 ATP binding site [chemical binding]; other site 762948004178 substrate binding site [chemical binding]; other site 762948004179 activation loop (A-loop); other site 762948004180 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 762948004181 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762948004182 substrate binding pocket [chemical binding]; other site 762948004183 chain length determination region; other site 762948004184 substrate-Mg2+ binding site; other site 762948004185 catalytic residues [active] 762948004186 aspartate-rich region 1; other site 762948004187 active site lid residues [active] 762948004188 aspartate-rich region 2; other site 762948004189 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 762948004190 active site 762948004191 DNA polymerase IV; Validated; Region: PRK02406 762948004192 DNA binding site [nucleotide binding] 762948004193 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 762948004194 cell division protein MraZ; Reviewed; Region: PRK00326 762948004195 MraZ protein; Region: MraZ; pfam02381 762948004196 MraZ protein; Region: MraZ; pfam02381 762948004197 MraW methylase family; Region: Methyltransf_5; cl17771 762948004198 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 762948004199 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 762948004200 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 762948004201 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 762948004202 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 762948004203 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762948004204 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762948004205 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762948004206 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 762948004207 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762948004208 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762948004209 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762948004210 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 762948004211 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 762948004212 Mg++ binding site [ion binding]; other site 762948004213 putative catalytic motif [active] 762948004214 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 762948004215 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762948004216 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762948004217 cell division protein FtsW; Region: ftsW; TIGR02614 762948004218 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 762948004219 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 762948004220 active site 762948004221 homodimer interface [polypeptide binding]; other site 762948004222 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 762948004223 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762948004224 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762948004225 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762948004226 cell division protein FtsQ; Provisional; Region: PRK05529 762948004227 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 762948004228 Cell division protein FtsQ; Region: FtsQ; pfam03799 762948004229 cell division protein FtsZ; Validated; Region: PRK09330 762948004230 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 762948004231 nucleotide binding site [chemical binding]; other site 762948004232 SulA interaction site; other site 762948004233 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 762948004234 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 762948004235 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 762948004236 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762948004237 catalytic residue [active] 762948004238 Protein of unknown function (DUF552); Region: DUF552; pfam04472 762948004239 DivIVA protein; Region: DivIVA; pfam05103 762948004240 DivIVA domain; Region: DivI1A_domain; TIGR03544 762948004241 lipoprotein signal peptidase; Provisional; Region: PRK14787 762948004242 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 762948004243 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762948004244 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762948004245 RNA binding surface [nucleotide binding]; other site 762948004246 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 762948004247 active site 762948004248 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 762948004249 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 762948004250 active site 762948004251 PHP Thumb interface [polypeptide binding]; other site 762948004252 metal binding site [ion binding]; metal-binding site 762948004253 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 762948004254 generic binding surface II; other site 762948004255 generic binding surface I; other site 762948004256 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 762948004257 ATP cone domain; Region: ATP-cone; pfam03477 762948004258 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762948004259 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 762948004260 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 762948004261 active site 762948004262 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 762948004263 oligomerization interface [polypeptide binding]; other site 762948004264 active site 762948004265 metal binding site [ion binding]; metal-binding site 762948004266 The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921 762948004267 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 762948004268 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 762948004269 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 762948004270 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 762948004271 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 762948004272 metal binding triad; other site 762948004273 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 762948004274 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 762948004275 metal binding triad; other site 762948004276 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 762948004277 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 762948004278 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 762948004279 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 762948004280 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 762948004281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762948004282 ATP binding site [chemical binding]; other site 762948004283 putative Mg++ binding site [ion binding]; other site 762948004284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762948004285 nucleotide binding region [chemical binding]; other site 762948004286 ATP-binding site [chemical binding]; other site 762948004287 Helicase associated domain (HA2); Region: HA2; pfam04408 762948004288 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 762948004289 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 762948004290 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762948004291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762948004292 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762948004293 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 762948004294 putative NAD(P) binding site [chemical binding]; other site 762948004295 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 762948004296 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 762948004297 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 762948004298 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 762948004299 active site 762948004300 HIGH motif; other site 762948004301 KMSK motif region; other site 762948004302 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762948004303 tRNA binding surface [nucleotide binding]; other site 762948004304 anticodon binding site; other site 762948004305 diaminopimelate decarboxylase; Region: lysA; TIGR01048 762948004306 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 762948004307 active site 762948004308 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762948004309 substrate binding site [chemical binding]; other site 762948004310 catalytic residues [active] 762948004311 dimer interface [polypeptide binding]; other site 762948004312 homoserine dehydrogenase; Provisional; Region: PRK06349 762948004313 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 762948004314 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 762948004315 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 762948004316 threonine synthase; Reviewed; Region: PRK06721 762948004317 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 762948004318 homodimer interface [polypeptide binding]; other site 762948004319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948004320 catalytic residue [active] 762948004321 homoserine kinase; Provisional; Region: PRK01212 762948004322 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 762948004323 transcription termination factor Rho; Provisional; Region: PRK12608 762948004324 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 762948004325 RNA binding site [nucleotide binding]; other site 762948004326 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 762948004327 multimer interface [polypeptide binding]; other site 762948004328 Walker A motif; other site 762948004329 ATP binding site [chemical binding]; other site 762948004330 Walker B motif; other site 762948004331 peptide chain release factor 1; Validated; Region: prfA; PRK00591 762948004332 This domain is found in peptide chain release factors; Region: PCRF; smart00937 762948004333 RF-1 domain; Region: RF-1; pfam00472 762948004334 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 762948004335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948004336 S-adenosylmethionine binding site [chemical binding]; other site 762948004337 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 762948004338 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 762948004339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762948004340 NAD(P) binding site [chemical binding]; other site 762948004341 active site 762948004342 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 762948004343 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762948004344 active site 762948004345 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762948004346 active site 762948004347 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 762948004348 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762948004349 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 762948004350 NAD(P) binding site [chemical binding]; other site 762948004351 homodimer interface [polypeptide binding]; other site 762948004352 substrate binding site [chemical binding]; other site 762948004353 active site 762948004354 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 762948004355 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 762948004356 Mg++ binding site [ion binding]; other site 762948004357 putative catalytic motif [active] 762948004358 putative substrate binding site [chemical binding]; other site 762948004359 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 762948004360 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 762948004361 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636 762948004362 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 762948004363 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 762948004364 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 762948004365 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 762948004366 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 762948004367 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762948004368 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 762948004369 beta subunit interaction interface [polypeptide binding]; other site 762948004370 Walker A motif; other site 762948004371 ATP binding site [chemical binding]; other site 762948004372 Walker B motif; other site 762948004373 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762948004374 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 762948004375 core domain interface [polypeptide binding]; other site 762948004376 delta subunit interface [polypeptide binding]; other site 762948004377 epsilon subunit interface [polypeptide binding]; other site 762948004378 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 762948004379 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762948004380 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 762948004381 alpha subunit interaction interface [polypeptide binding]; other site 762948004382 Walker A motif; other site 762948004383 ATP binding site [chemical binding]; other site 762948004384 Walker B motif; other site 762948004385 inhibitor binding site; inhibition site 762948004386 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762948004387 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 762948004388 gamma subunit interface [polypeptide binding]; other site 762948004389 epsilon subunit interface [polypeptide binding]; other site 762948004390 LBP interface [polypeptide binding]; other site 762948004391 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 762948004392 hypothetical protein; Provisional; Region: PRK03298 762948004393 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762948004394 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762948004395 Domain of unknown function DUF20; Region: UPF0118; pfam01594 762948004396 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 762948004397 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762948004398 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 762948004399 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762948004400 Walker A/P-loop; other site 762948004401 ATP binding site [chemical binding]; other site 762948004402 Q-loop/lid; other site 762948004403 ABC transporter signature motif; other site 762948004404 Walker B; other site 762948004405 D-loop; other site 762948004406 H-loop/switch region; other site 762948004407 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 762948004408 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 762948004409 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762948004410 ATP binding site [chemical binding]; other site 762948004411 putative Mg++ binding site [ion binding]; other site 762948004412 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 762948004413 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 762948004414 Isochorismatase family; Region: Isochorismatase; pfam00857 762948004415 catalytic triad [active] 762948004416 metal binding site [ion binding]; metal-binding site 762948004417 conserved cis-peptide bond; other site 762948004418 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 762948004419 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 762948004420 active site 762948004421 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 762948004422 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 762948004423 glutamate racemase; Provisional; Region: PRK00865 762948004424 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 762948004425 ribonuclease PH; Reviewed; Region: rph; PRK00173 762948004426 Ribonuclease PH; Region: RNase_PH_bact; cd11362 762948004427 hexamer interface [polypeptide binding]; other site 762948004428 active site 762948004429 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 762948004430 active site 762948004431 dimerization interface [polypeptide binding]; other site 762948004432 RDD family; Region: RDD; cl00746 762948004433 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 762948004434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762948004435 ATP binding site [chemical binding]; other site 762948004436 Mg2+ binding site [ion binding]; other site 762948004437 G-X-G motif; other site 762948004438 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 762948004439 anchoring element; other site 762948004440 dimer interface [polypeptide binding]; other site 762948004441 ATP binding site [chemical binding]; other site 762948004442 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 762948004443 active site 762948004444 metal binding site [ion binding]; metal-binding site 762948004445 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762948004446 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 762948004447 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 762948004448 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 762948004449 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 762948004450 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 762948004451 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762948004452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948004453 Walker A/P-loop; other site 762948004454 ATP binding site [chemical binding]; other site 762948004455 Q-loop/lid; other site 762948004456 ABC transporter signature motif; other site 762948004457 D-loop; other site 762948004458 H-loop/switch region; other site 762948004459 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 762948004460 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 762948004461 Walker A/P-loop; other site 762948004462 ATP binding site [chemical binding]; other site 762948004463 Q-loop/lid; other site 762948004464 ABC transporter signature motif; other site 762948004465 Walker B; other site 762948004466 D-loop; other site 762948004467 H-loop/switch region; other site 762948004468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762948004469 Coenzyme A binding pocket [chemical binding]; other site 762948004470 (R)-citramalate synthase; Provisional; Region: PRK09389 762948004471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762948004472 TPR motif; other site 762948004473 binding surface 762948004474 TPR repeat; Region: TPR_11; pfam13414 762948004475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762948004476 binding surface 762948004477 TPR motif; other site 762948004478 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762948004479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762948004480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762948004481 Coenzyme A binding pocket [chemical binding]; other site 762948004482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762948004483 binding surface 762948004484 TPR motif; other site 762948004485 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 762948004486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762948004487 binding surface 762948004488 TPR motif; other site 762948004489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762948004490 binding surface 762948004491 TPR motif; other site 762948004492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762948004493 binding surface 762948004494 TPR motif; other site 762948004495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762948004496 binding surface 762948004497 TPR motif; other site 762948004498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762948004499 binding surface 762948004500 TPR motif; other site 762948004501 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 762948004502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762948004503 binding surface 762948004504 TPR motif; other site 762948004505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762948004506 binding surface 762948004507 TPR motif; other site 762948004508 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 762948004509 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 762948004510 CAP-like domain; other site 762948004511 active site 762948004512 primary dimer interface [polypeptide binding]; other site 762948004513 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 762948004514 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 762948004515 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 762948004516 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 762948004517 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 762948004518 trimer interface [polypeptide binding]; other site 762948004519 active site 762948004520 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 762948004521 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 762948004522 generic binding surface I; other site 762948004523 generic binding surface II; other site 762948004524 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 762948004525 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 762948004526 TrkA-N domain; Region: TrkA_N; pfam02254 762948004527 TrkA-C domain; Region: TrkA_C; pfam02080 762948004528 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 762948004529 TrkA-N domain; Region: TrkA_N; pfam02254 762948004530 TrkA-C domain; Region: TrkA_C; pfam02080 762948004531 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 762948004532 TRAM domain; Region: TRAM; cl01282 762948004533 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 762948004534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948004535 S-adenosylmethionine binding site [chemical binding]; other site 762948004536 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 762948004537 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 762948004538 TPP-binding site [chemical binding]; other site 762948004539 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762948004540 PYR/PP interface [polypeptide binding]; other site 762948004541 dimer interface [polypeptide binding]; other site 762948004542 TPP binding site [chemical binding]; other site 762948004543 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762948004544 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 762948004545 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 762948004546 iron-sulfur cluster [ion binding]; other site 762948004547 [2Fe-2S] cluster binding site [ion binding]; other site 762948004548 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 762948004549 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 762948004550 catalytic site [active] 762948004551 putative active site [active] 762948004552 putative substrate binding site [chemical binding]; other site 762948004553 HRDC domain; Region: HRDC; cl02578 762948004554 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 762948004555 SelR domain; Region: SelR; pfam01641 762948004556 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762948004557 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 762948004558 putative deacylase active site [active] 762948004559 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 762948004560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762948004561 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762948004562 DNA binding residues [nucleotide binding] 762948004563 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 762948004564 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 762948004565 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 762948004566 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762948004567 catalytic residues [active] 762948004568 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 762948004569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 762948004570 methionine sulfoxide reductase A; Provisional; Region: PRK14054 762948004571 Uncharacterized conserved protein [Function unknown]; Region: COG0327 762948004572 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 762948004573 S-layer homology domain; Region: SLH; pfam00395 762948004574 S-layer homology domain; Region: SLH; pfam00395 762948004575 S-layer homology domain; Region: SLH; pfam00395 762948004576 hypothetical protein; Validated; Region: PRK02101 762948004577 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 762948004578 active site 762948004579 catalytic residues [active] 762948004580 metal binding site [ion binding]; metal-binding site 762948004581 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762948004582 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762948004583 active site 762948004584 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 762948004585 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 762948004586 dimer interface [polypeptide binding]; other site 762948004587 ssDNA binding site [nucleotide binding]; other site 762948004588 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762948004589 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 762948004590 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 762948004591 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 762948004592 putative active site [active] 762948004593 putative substrate binding site [chemical binding]; other site 762948004594 dimer interface [polypeptide binding]; other site 762948004595 catalytic site [active] 762948004596 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 762948004597 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 762948004598 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762948004599 Catalytic site [active] 762948004600 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 762948004601 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762948004602 Catalytic site [active] 762948004603 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 762948004604 RNA/DNA hybrid binding site [nucleotide binding]; other site 762948004605 active site 762948004606 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 762948004607 hypothetical protein; Reviewed; Region: PRK12497 762948004608 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 762948004609 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 762948004610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762948004611 Walker A motif; other site 762948004612 ATP binding site [chemical binding]; other site 762948004613 Walker B motif; other site 762948004614 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 762948004615 DNA protecting protein DprA; Region: dprA; TIGR00732 762948004616 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 762948004617 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 762948004618 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762948004619 active site 762948004620 DNA binding site [nucleotide binding] 762948004621 Int/Topo IB signature motif; other site 762948004622 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 762948004623 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 762948004624 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 762948004625 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 762948004626 dimer interface [polypeptide binding]; other site 762948004627 active site 762948004628 CoA binding pocket [chemical binding]; other site 762948004629 acyl carrier protein; Provisional; Region: acpP; PRK00982 762948004630 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 762948004631 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 762948004632 dimer interface [polypeptide binding]; other site 762948004633 active site 762948004634 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 762948004635 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 762948004636 active site 762948004637 S-layer homology domain; Region: SLH; pfam00395 762948004638 S-layer homology domain; Region: SLH; pfam00395 762948004639 S-layer homology domain; Region: SLH; pfam00395 762948004640 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 762948004641 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 762948004642 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 762948004643 catalytic motif [active] 762948004644 Zn binding site [ion binding]; other site 762948004645 RibD C-terminal domain; Region: RibD_C; pfam01872 762948004646 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 762948004647 Lumazine binding domain; Region: Lum_binding; pfam00677 762948004648 Lumazine binding domain; Region: Lum_binding; pfam00677 762948004649 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 762948004650 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 762948004651 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 762948004652 dimerization interface [polypeptide binding]; other site 762948004653 active site 762948004654 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 762948004655 homopentamer interface [polypeptide binding]; other site 762948004656 active site 762948004657 anthranilate synthase component I; Provisional; Region: PRK13571 762948004658 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 762948004659 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 762948004660 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 762948004661 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 762948004662 active site 762948004663 ribulose/triose binding site [chemical binding]; other site 762948004664 phosphate binding site [ion binding]; other site 762948004665 substrate (anthranilate) binding pocket [chemical binding]; other site 762948004666 product (indole) binding pocket [chemical binding]; other site 762948004667 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 762948004668 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 762948004669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948004670 catalytic residue [active] 762948004671 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 762948004672 substrate binding site [chemical binding]; other site 762948004673 active site 762948004674 catalytic residues [active] 762948004675 heterodimer interface [polypeptide binding]; other site 762948004676 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 762948004677 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 762948004678 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 762948004679 pyruvate kinase; Provisional; Region: PRK06247 762948004680 domain interfaces; other site 762948004681 active site 762948004682 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 762948004683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762948004684 active site 762948004685 phosphorylation site [posttranslational modification] 762948004686 intermolecular recognition site; other site 762948004687 dimerization interface [polypeptide binding]; other site 762948004688 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 762948004689 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762948004690 CoenzymeA binding site [chemical binding]; other site 762948004691 subunit interaction site [polypeptide binding]; other site 762948004692 PHB binding site; other site 762948004693 SnoaL-like domain; Region: SnoaL_2; pfam12680 762948004694 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 762948004695 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 762948004696 DNA polymerase I; Provisional; Region: PRK05755 762948004697 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 762948004698 active site 762948004699 putative 5' ssDNA interaction site; other site 762948004700 metal binding site 3; metal-binding site 762948004701 metal binding site 1 [ion binding]; metal-binding site 762948004702 metal binding site 2 [ion binding]; metal-binding site 762948004703 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 762948004704 putative DNA binding site [nucleotide binding]; other site 762948004705 putative metal binding site [ion binding]; other site 762948004706 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 762948004707 active site 762948004708 substrate binding site [chemical binding]; other site 762948004709 catalytic site [active] 762948004710 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 762948004711 active site 762948004712 DNA binding site [nucleotide binding] 762948004713 catalytic site [active] 762948004714 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 762948004715 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 762948004716 RNA binding site [nucleotide binding]; other site 762948004717 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 762948004718 RNA binding site [nucleotide binding]; other site 762948004719 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762948004720 RNA binding site [nucleotide binding]; other site 762948004721 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762948004722 RNA binding site [nucleotide binding]; other site 762948004723 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 762948004724 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 762948004725 CoA-binding site [chemical binding]; other site 762948004726 ATP-binding [chemical binding]; other site 762948004727 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 762948004728 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 762948004729 excinuclease ABC subunit B; Provisional; Region: PRK05298 762948004730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 762948004731 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762948004732 nucleotide binding region [chemical binding]; other site 762948004733 ATP-binding site [chemical binding]; other site 762948004734 Ultra-violet resistance protein B; Region: UvrB; pfam12344 762948004735 UvrB/uvrC motif; Region: UVR; pfam02151 762948004736 Predicted transcriptional regulators [Transcription]; Region: COG1733 762948004737 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762948004738 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 762948004739 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762948004740 NAD binding site [chemical binding]; other site 762948004741 substrate binding site [chemical binding]; other site 762948004742 putative active site [active] 762948004743 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 762948004744 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762948004745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762948004746 ATP binding site [chemical binding]; other site 762948004747 putative Mg++ binding site [ion binding]; other site 762948004748 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762948004749 nucleotide binding region [chemical binding]; other site 762948004750 ATP-binding site [chemical binding]; other site 762948004751 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 762948004752 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762948004753 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762948004754 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948004755 ABC transporter signature motif; other site 762948004756 Walker B; other site 762948004757 D-loop; other site 762948004758 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762948004759 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762948004760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948004761 Walker A/P-loop; other site 762948004762 ATP binding site [chemical binding]; other site 762948004763 Q-loop/lid; other site 762948004764 ABC transporter signature motif; other site 762948004765 Walker B; other site 762948004766 D-loop; other site 762948004767 H-loop/switch region; other site 762948004768 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 762948004769 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 762948004770 dimer interface [polypeptide binding]; other site 762948004771 substrate binding site [chemical binding]; other site 762948004772 ATP binding site [chemical binding]; other site 762948004773 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 762948004774 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 762948004775 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 762948004776 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 762948004777 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 762948004778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762948004779 ATP binding site [chemical binding]; other site 762948004780 putative Mg++ binding site [ion binding]; other site 762948004781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 762948004782 nucleotide binding region [chemical binding]; other site 762948004783 ATP-binding site [chemical binding]; other site 762948004784 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 762948004785 active site 762948004786 catalytic site [active] 762948004787 substrate binding site [chemical binding]; other site 762948004788 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762948004789 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 762948004790 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762948004791 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 762948004792 HsdM N-terminal domain; Region: HsdM_N; pfam12161 762948004793 Methyltransferase domain; Region: Methyltransf_26; pfam13659 762948004794 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 762948004795 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 762948004796 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762948004797 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 762948004798 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 762948004799 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 762948004800 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 762948004801 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 762948004802 Binuclear center (active site) [active] 762948004803 K-pathway; other site 762948004804 Putative proton exit pathway; other site 762948004805 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 762948004806 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762948004807 putative acyl-acceptor binding pocket; other site 762948004808 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 762948004809 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 762948004810 GIY-YIG motif/motif A; other site 762948004811 active site 762948004812 catalytic site [active] 762948004813 putative DNA binding site [nucleotide binding]; other site 762948004814 metal binding site [ion binding]; metal-binding site 762948004815 UvrB/uvrC motif; Region: UVR; pfam02151 762948004816 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 762948004817 Helix-hairpin-helix motif; Region: HHH; pfam00633 762948004818 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 762948004819 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 762948004820 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 762948004821 putative substrate binding pocket [chemical binding]; other site 762948004822 dimer interface [polypeptide binding]; other site 762948004823 phosphate binding site [ion binding]; other site 762948004824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 762948004825 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 762948004826 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 762948004827 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 762948004828 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 762948004829 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 762948004830 Phosphoglycerate kinase; Region: PGK; pfam00162 762948004831 substrate binding site [chemical binding]; other site 762948004832 hinge regions; other site 762948004833 ADP binding site [chemical binding]; other site 762948004834 catalytic site [active] 762948004835 triosephosphate isomerase; Provisional; Region: PRK14567 762948004836 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 762948004837 substrate binding site [chemical binding]; other site 762948004838 dimer interface [polypeptide binding]; other site 762948004839 catalytic triad [active] 762948004840 BCCT family transporter; Region: BCCT; pfam02028 762948004841 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009 762948004842 SWIM zinc finger; Region: SWIM; pfam04434 762948004843 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 762948004844 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 762948004845 putative active site [active] 762948004846 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 762948004847 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 762948004848 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 762948004849 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 762948004850 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 762948004851 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 762948004852 putative active site [active] 762948004853 transaldolase; Provisional; Region: PRK03903 762948004854 catalytic residue [active] 762948004855 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 762948004856 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 762948004857 TPP-binding site [chemical binding]; other site 762948004858 dimer interface [polypeptide binding]; other site 762948004859 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762948004860 PYR/PP interface [polypeptide binding]; other site 762948004861 dimer interface [polypeptide binding]; other site 762948004862 TPP binding site [chemical binding]; other site 762948004863 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762948004864 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 762948004865 UbiA prenyltransferase family; Region: UbiA; pfam01040 762948004866 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 762948004867 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 762948004868 ABC-2 type transporter; Region: ABC2_membrane; cl17235 762948004869 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 762948004870 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762948004871 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762948004872 Walker A/P-loop; other site 762948004873 ATP binding site [chemical binding]; other site 762948004874 Q-loop/lid; other site 762948004875 ABC transporter signature motif; other site 762948004876 Walker B; other site 762948004877 D-loop; other site 762948004878 H-loop/switch region; other site 762948004879 Predicted transcriptional regulator [Transcription]; Region: COG2345 762948004880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762948004881 putative DNA binding site [nucleotide binding]; other site 762948004882 putative Zn2+ binding site [ion binding]; other site 762948004883 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 762948004884 FeS assembly protein SufB; Region: sufB; TIGR01980 762948004885 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 762948004886 FeS assembly protein SufD; Region: sufD; TIGR01981 762948004887 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 762948004888 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 762948004889 Walker A/P-loop; other site 762948004890 ATP binding site [chemical binding]; other site 762948004891 Q-loop/lid; other site 762948004892 ABC transporter signature motif; other site 762948004893 Walker B; other site 762948004894 D-loop; other site 762948004895 H-loop/switch region; other site 762948004896 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 762948004897 HD domain; Region: HD_4; pfam13328 762948004898 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762948004899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762948004900 Coenzyme A binding pocket [chemical binding]; other site 762948004901 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 762948004902 Cobalt transport protein; Region: CbiQ; cl00463 762948004903 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762948004904 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762948004905 Walker A/P-loop; other site 762948004906 ATP binding site [chemical binding]; other site 762948004907 Q-loop/lid; other site 762948004908 ABC transporter signature motif; other site 762948004909 Walker B; other site 762948004910 D-loop; other site 762948004911 H-loop/switch region; other site 762948004912 BioY family; Region: BioY; pfam02632 762948004913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948004914 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762948004915 Walker A/P-loop; other site 762948004916 ATP binding site [chemical binding]; other site 762948004917 Q-loop/lid; other site 762948004918 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762948004919 ABC transporter; Region: ABC_tran_2; pfam12848 762948004920 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762948004921 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 762948004922 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 762948004923 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 762948004924 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762948004925 NAD(P) binding site [chemical binding]; other site 762948004926 homotetramer interface [polypeptide binding]; other site 762948004927 homodimer interface [polypeptide binding]; other site 762948004928 active site 762948004929 short chain dehydrogenase; Provisional; Region: PRK07806 762948004930 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 762948004931 NAD(P) binding site [chemical binding]; other site 762948004932 active site 762948004933 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 762948004934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948004935 Walker A/P-loop; other site 762948004936 ATP binding site [chemical binding]; other site 762948004937 Q-loop/lid; other site 762948004938 ABC transporter signature motif; other site 762948004939 Walker B; other site 762948004940 D-loop; other site 762948004941 H-loop/switch region; other site 762948004942 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 762948004943 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762948004944 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 762948004945 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 762948004946 HIRAN domain; Region: HIRAN; cl07418 762948004947 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 762948004948 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 762948004949 Zn binding site [ion binding]; other site 762948004950 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762948004951 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 762948004952 putative NAD(P) binding site [chemical binding]; other site 762948004953 catalytic Zn binding site [ion binding]; other site 762948004954 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 762948004955 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 762948004956 NAD binding site [chemical binding]; other site 762948004957 dimer interface [polypeptide binding]; other site 762948004958 substrate binding site [chemical binding]; other site 762948004959 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762948004960 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 762948004961 Recombination protein O N terminal; Region: RecO_N; pfam11967 762948004962 Recombination protein O C terminal; Region: RecO_C; pfam02565 762948004963 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 762948004964 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 762948004965 catalytic residue [active] 762948004966 putative FPP diphosphate binding site; other site 762948004967 putative FPP binding hydrophobic cleft; other site 762948004968 dimer interface [polypeptide binding]; other site 762948004969 putative IPP diphosphate binding site; other site 762948004970 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 762948004971 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 762948004972 quinone interaction residues [chemical binding]; other site 762948004973 active site 762948004974 catalytic residues [active] 762948004975 FMN binding site [chemical binding]; other site 762948004976 substrate binding site [chemical binding]; other site 762948004977 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 762948004978 hypothetical protein; Provisional; Region: PRK07907 762948004979 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 762948004980 active site 762948004981 metal binding site [ion binding]; metal-binding site 762948004982 dimer interface [polypeptide binding]; other site 762948004983 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 762948004984 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 762948004985 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 762948004986 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 762948004987 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 762948004988 D-pathway; other site 762948004989 Putative ubiquinol binding site [chemical binding]; other site 762948004990 Low-spin heme (heme b) binding site [chemical binding]; other site 762948004991 Putative water exit pathway; other site 762948004992 Binuclear center (heme o3/CuB) [ion binding]; other site 762948004993 K-pathway; other site 762948004994 Putative proton exit pathway; other site 762948004995 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 762948004996 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 762948004997 heme bH binding site [chemical binding]; other site 762948004998 Qi binding site; other site 762948004999 intrachain domain interface; other site 762948005000 heme bL binding site [chemical binding]; other site 762948005001 interchain domain interface [polypeptide binding]; other site 762948005002 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 762948005003 Qo binding site; other site 762948005004 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 762948005005 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 762948005006 iron-sulfur cluster [ion binding]; other site 762948005007 [2Fe-2S] cluster binding site [ion binding]; other site 762948005008 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762948005009 Cytochrome c; Region: Cytochrom_C; pfam00034 762948005010 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762948005011 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 762948005012 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 762948005013 Subunit I/III interface [polypeptide binding]; other site 762948005014 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 762948005015 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 762948005016 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 762948005017 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 762948005018 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 762948005019 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 762948005020 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 762948005021 Amino acid permease; Region: AA_permease; pfam00324 762948005022 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 762948005023 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762948005024 inhibitor-cofactor binding pocket; inhibition site 762948005025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948005026 catalytic residue [active] 762948005027 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 762948005028 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 762948005029 tetrameric interface [polypeptide binding]; other site 762948005030 NAD binding site [chemical binding]; other site 762948005031 catalytic residues [active] 762948005032 substrate binding site [chemical binding]; other site 762948005033 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762948005034 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 762948005035 tetramerization interface [polypeptide binding]; other site 762948005036 NAD(P) binding site [chemical binding]; other site 762948005037 catalytic residues [active] 762948005038 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762948005039 Ligand Binding Site [chemical binding]; other site 762948005040 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762948005041 Ligand Binding Site [chemical binding]; other site 762948005042 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762948005043 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 762948005044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762948005045 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 762948005046 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 762948005047 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 762948005048 Ligand binding site; other site 762948005049 Putative Catalytic site; other site 762948005050 DXD motif; other site 762948005051 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 762948005052 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 762948005053 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762948005054 ATP binding site [chemical binding]; other site 762948005055 putative Mg++ binding site [ion binding]; other site 762948005056 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762948005057 nucleotide binding region [chemical binding]; other site 762948005058 ATP-binding site [chemical binding]; other site 762948005059 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 762948005060 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 762948005061 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 762948005062 WYL domain; Region: WYL; pfam13280 762948005063 WYL domain; Region: WYL; pfam13280 762948005064 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 762948005065 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 762948005066 Pup-ligase protein; Region: Pup_ligase; cl15463 762948005067 Pup-like protein; Region: Pup; pfam05639 762948005068 Pup-ligase protein; Region: Pup_ligase; pfam03136 762948005069 proteasome ATPase; Region: pup_AAA; TIGR03689 762948005070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762948005071 Walker A motif; other site 762948005072 ATP binding site [chemical binding]; other site 762948005073 Walker B motif; other site 762948005074 arginine finger; other site 762948005075 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 762948005076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948005077 S-adenosylmethionine binding site [chemical binding]; other site 762948005078 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762948005079 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 762948005080 active site 762948005081 HIGH motif; other site 762948005082 nucleotide binding site [chemical binding]; other site 762948005083 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762948005084 active site 762948005085 KMSKS motif; other site 762948005086 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762948005087 tRNA binding surface [nucleotide binding]; other site 762948005088 anticodon binding site; other site 762948005089 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 762948005090 2-isopropylmalate synthase; Validated; Region: PRK03739 762948005091 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 762948005092 active site 762948005093 catalytic residues [active] 762948005094 metal binding site [ion binding]; metal-binding site 762948005095 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 762948005096 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 762948005097 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 762948005098 GTPase [General function prediction only]; Region: Era; COG1159 762948005099 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 762948005100 G1 box; other site 762948005101 GTP/Mg2+ binding site [chemical binding]; other site 762948005102 Switch I region; other site 762948005103 G2 box; other site 762948005104 Switch II region; other site 762948005105 G3 box; other site 762948005106 G4 box; other site 762948005107 KH domain; Region: KH_2; pfam07650 762948005108 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 762948005109 Domain of unknown function DUF21; Region: DUF21; pfam01595 762948005110 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762948005111 Transporter associated domain; Region: CorC_HlyC; smart01091 762948005112 metal-binding heat shock protein; Provisional; Region: PRK00016 762948005113 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 762948005114 PhoH-like protein; Region: PhoH; pfam02562 762948005115 RNA methyltransferase, RsmE family; Region: TIGR00046 762948005116 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 762948005117 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 762948005118 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 762948005119 HSP70 interaction site [polypeptide binding]; other site 762948005120 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 762948005121 substrate binding site [polypeptide binding]; other site 762948005122 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 762948005123 Zn binding sites [ion binding]; other site 762948005124 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 762948005125 dimer interface [polypeptide binding]; other site 762948005126 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 762948005127 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 762948005128 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 762948005129 Tic20-like protein; Region: Tic20; pfam09685 762948005130 coproporphyrinogen III oxidase; Validated; Region: PRK05628 762948005131 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762948005132 FeS/SAM binding site; other site 762948005133 HemN C-terminal domain; Region: HemN_C; pfam06969 762948005134 GTP-binding protein LepA; Provisional; Region: PRK05433 762948005135 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 762948005136 G1 box; other site 762948005137 putative GEF interaction site [polypeptide binding]; other site 762948005138 GTP/Mg2+ binding site [chemical binding]; other site 762948005139 Switch I region; other site 762948005140 G2 box; other site 762948005141 G3 box; other site 762948005142 Switch II region; other site 762948005143 G4 box; other site 762948005144 G5 box; other site 762948005145 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 762948005146 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 762948005147 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 762948005148 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 762948005149 PemK-like protein; Region: PemK; pfam02452 762948005150 hypothetical protein; Validated; Region: PRK05629 762948005151 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 762948005152 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 762948005153 Competence protein; Region: Competence; pfam03772 762948005154 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 762948005155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 762948005156 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 762948005157 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 762948005158 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 762948005159 HIGH motif; other site 762948005160 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 762948005161 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762948005162 active site 762948005163 KMSKS motif; other site 762948005164 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 762948005165 tRNA binding surface [nucleotide binding]; other site 762948005166 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762948005167 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 762948005168 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762948005169 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 762948005170 AAA ATPase domain; Region: AAA_15; pfam13175 762948005171 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 762948005172 putative active site [active] 762948005173 putative metal-binding site [ion binding]; other site 762948005174 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 762948005175 S-adenosylmethionine synthetase; Validated; Region: PRK05250 762948005176 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 762948005177 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 762948005178 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 762948005179 Flavoprotein; Region: Flavoprotein; pfam02441 762948005180 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 762948005181 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 762948005182 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 762948005183 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 762948005184 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 762948005185 catalytic site [active] 762948005186 G-X2-G-X-G-K; other site 762948005187 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 762948005188 active site 762948005189 dimer interface [polypeptide binding]; other site 762948005190 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 762948005191 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762948005192 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 762948005193 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 762948005194 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762948005195 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762948005196 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 762948005197 IMP binding site; other site 762948005198 dimer interface [polypeptide binding]; other site 762948005199 interdomain contacts; other site 762948005200 partial ornithine binding site; other site 762948005201 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 762948005202 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 762948005203 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 762948005204 catalytic site [active] 762948005205 subunit interface [polypeptide binding]; other site 762948005206 dihydroorotase; Validated; Region: pyrC; PRK09357 762948005207 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762948005208 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 762948005209 active site 762948005210 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 762948005211 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 762948005212 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762948005213 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 762948005214 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762948005215 active site 762948005216 transcription antitermination factor NusB; Region: nusB; TIGR01951 762948005217 putative RNA binding site [nucleotide binding]; other site 762948005218 elongation factor P; Validated; Region: PRK00529 762948005219 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 762948005220 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 762948005221 RNA binding site [nucleotide binding]; other site 762948005222 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 762948005223 RNA binding site [nucleotide binding]; other site 762948005224 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 762948005225 active site 762948005226 dimer interface [polypeptide binding]; other site 762948005227 metal binding site [ion binding]; metal-binding site 762948005228 shikimate kinase; Reviewed; Region: aroK; PRK00131 762948005229 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 762948005230 ADP binding site [chemical binding]; other site 762948005231 magnesium binding site [ion binding]; other site 762948005232 putative shikimate binding site; other site 762948005233 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 762948005234 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 762948005235 Tetramer interface [polypeptide binding]; other site 762948005236 active site 762948005237 FMN-binding site [chemical binding]; other site 762948005238 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 762948005239 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 762948005240 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 762948005241 shikimate binding site; other site 762948005242 NAD(P) binding site [chemical binding]; other site 762948005243 YceG-like family; Region: YceG; pfam02618 762948005244 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 762948005245 dimerization interface [polypeptide binding]; other site 762948005246 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 762948005247 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 762948005248 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 762948005249 motif 1; other site 762948005250 active site 762948005251 motif 2; other site 762948005252 motif 3; other site 762948005253 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 762948005254 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 762948005255 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 762948005256 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762948005257 RNA binding surface [nucleotide binding]; other site 762948005258 recombination factor protein RarA; Reviewed; Region: PRK13342 762948005259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762948005260 Walker A motif; other site 762948005261 ATP binding site [chemical binding]; other site 762948005262 Walker B motif; other site 762948005263 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 762948005264 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 762948005265 putative active site [active] 762948005266 dimerization interface [polypeptide binding]; other site 762948005267 putative tRNAtyr binding site [nucleotide binding]; other site 762948005268 topology modulation protein; Reviewed; Region: PRK08118 762948005269 AAA domain; Region: AAA_17; pfam13207 762948005270 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 762948005271 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 762948005272 dimer interface [polypeptide binding]; other site 762948005273 anticodon binding site; other site 762948005274 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 762948005275 homodimer interface [polypeptide binding]; other site 762948005276 motif 1; other site 762948005277 active site 762948005278 motif 2; other site 762948005279 GAD domain; Region: GAD; pfam02938 762948005280 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762948005281 active site 762948005282 motif 3; other site 762948005283 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 762948005284 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 762948005285 dimer interface [polypeptide binding]; other site 762948005286 motif 1; other site 762948005287 active site 762948005288 motif 2; other site 762948005289 motif 3; other site 762948005290 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 762948005291 anticodon binding site; other site 762948005292 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 762948005293 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 762948005294 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 762948005295 HD domain; Region: HD_4; pfam13328 762948005296 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 762948005297 synthetase active site [active] 762948005298 NTP binding site [chemical binding]; other site 762948005299 metal binding site [ion binding]; metal-binding site 762948005300 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 762948005301 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 762948005302 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 762948005303 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 762948005304 Protein export membrane protein; Region: SecD_SecF; cl14618 762948005305 protein-export membrane protein SecD; Region: secD; TIGR01129 762948005306 Protein export membrane protein; Region: SecD_SecF; cl14618 762948005307 Preprotein translocase subunit; Region: YajC; pfam02699 762948005308 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 762948005309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762948005310 Walker A motif; other site 762948005311 ATP binding site [chemical binding]; other site 762948005312 Walker B motif; other site 762948005313 arginine finger; other site 762948005314 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 762948005315 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 762948005316 RuvA N terminal domain; Region: RuvA_N; pfam01330 762948005317 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 762948005318 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 762948005319 active site 762948005320 putative DNA-binding cleft [nucleotide binding]; other site 762948005321 dimer interface [polypeptide binding]; other site 762948005322 hypothetical protein; Validated; Region: PRK00110 762948005323 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 762948005324 catalytic triad [active] 762948005325 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 762948005326 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762948005327 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 762948005328 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 762948005329 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 762948005330 nucleotide binding site/active site [active] 762948005331 HIT family signature motif; other site 762948005332 catalytic residue [active] 762948005333 Ion channel; Region: Ion_trans_2; pfam07885 762948005334 potential frameshift: common BLAST hit: gi|283457980|ref|YP_003362587.1| FAD/FMN-containing dehydrogenase 762948005335 A new structural DNA glycosylase; Region: AlkD_like; cl11434 762948005336 active site 762948005337 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 762948005338 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 762948005339 Cysteine-rich domain; Region: CCG; pfam02754 762948005340 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 762948005341 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 762948005342 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 762948005343 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 762948005344 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 762948005345 active site 762948005346 dimer interface [polypeptide binding]; other site 762948005347 motif 1; other site 762948005348 motif 2; other site 762948005349 motif 3; other site 762948005350 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 762948005351 anticodon binding site; other site 762948005352 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762948005353 FAD binding domain; Region: FAD_binding_4; pfam01565 762948005354 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 762948005355 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762948005356 dimerization interface [polypeptide binding]; other site 762948005357 putative DNA binding site [nucleotide binding]; other site 762948005358 putative Zn2+ binding site [ion binding]; other site 762948005359 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762948005360 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762948005361 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 762948005362 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 762948005363 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 762948005364 transmembrane helices; other site 762948005365 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 762948005366 beta-galactosidase; Region: BGL; TIGR03356 762948005367 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 762948005368 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762948005369 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762948005370 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 762948005371 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762948005372 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 762948005373 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 762948005374 Potassium binding sites [ion binding]; other site 762948005375 Cesium cation binding sites [ion binding]; other site 762948005376 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 762948005377 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762948005378 catalytic Zn binding site [ion binding]; other site 762948005379 NAD(P) binding site [chemical binding]; other site 762948005380 structural Zn binding site [ion binding]; other site 762948005381 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 762948005382 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 762948005383 DNA binding residues [nucleotide binding] 762948005384 putative dimer interface [polypeptide binding]; other site 762948005385 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 762948005386 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 762948005387 dimer interface [polypeptide binding]; other site 762948005388 putative radical transfer pathway; other site 762948005389 diiron center [ion binding]; other site 762948005390 tyrosyl radical; other site 762948005391 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 762948005392 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 762948005393 Class I ribonucleotide reductase; Region: RNR_I; cd01679 762948005394 active site 762948005395 dimer interface [polypeptide binding]; other site 762948005396 catalytic residues [active] 762948005397 effector binding site; other site 762948005398 R2 peptide binding site; other site 762948005399 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 762948005400 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 762948005401 catalytic residues [active] 762948005402 Uncharacterized conserved protein [Function unknown]; Region: COG4850 762948005403 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 762948005404 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 762948005405 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 762948005406 NodB motif; other site 762948005407 active site 762948005408 catalytic site [active] 762948005409 metal binding site [ion binding]; metal-binding site 762948005410 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 762948005411 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 762948005412 catalytic residues [active] 762948005413 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 762948005414 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 762948005415 NodB motif; other site 762948005416 active site 762948005417 catalytic site [active] 762948005418 metal binding site [ion binding]; metal-binding site 762948005419 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 762948005420 topology modulation protein; Reviewed; Region: PRK08118 762948005421 AAA domain; Region: AAA_17; pfam13207 762948005422 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 762948005423 glutaminase; Provisional; Region: PRK00971 762948005424 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 762948005425 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 762948005426 classical (c) SDRs; Region: SDR_c; cd05233 762948005427 NAD(P) binding site [chemical binding]; other site 762948005428 active site 762948005429 Oligomerisation domain; Region: Oligomerisation; pfam02410 762948005430 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 762948005431 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 762948005432 active site 762948005433 (T/H)XGH motif; other site 762948005434 GTPase CgtA; Reviewed; Region: obgE; PRK12296 762948005435 GTP1/OBG; Region: GTP1_OBG; pfam01018 762948005436 Obg GTPase; Region: Obg; cd01898 762948005437 G1 box; other site 762948005438 GTP/Mg2+ binding site [chemical binding]; other site 762948005439 Switch I region; other site 762948005440 G2 box; other site 762948005441 G3 box; other site 762948005442 Switch II region; other site 762948005443 G4 box; other site 762948005444 G5 box; other site 762948005445 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 762948005446 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 762948005447 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 762948005448 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 762948005449 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 762948005450 homodimer interface [polypeptide binding]; other site 762948005451 oligonucleotide binding site [chemical binding]; other site 762948005452 ALG3 protein; Region: ALG3; pfam05208 762948005453 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 762948005454 active site 762948005455 multimer interface [polypeptide binding]; other site 762948005456 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 762948005457 putative active site [active] 762948005458 redox center [active] 762948005459 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 762948005460 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 762948005461 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762948005462 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762948005463 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 762948005464 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 762948005465 HIGH motif; other site 762948005466 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 762948005467 active site 762948005468 KMSKS motif; other site 762948005469 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 762948005470 tRNA binding surface [nucleotide binding]; other site 762948005471 anticodon binding site; other site 762948005472 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 762948005473 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 762948005474 nitrite reductase subunit NirD; Provisional; Region: PRK14989 762948005475 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 762948005476 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 762948005477 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 762948005478 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 762948005479 active site 762948005480 SAM binding site [chemical binding]; other site 762948005481 homodimer interface [polypeptide binding]; other site 762948005482 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 762948005483 putative active site [active] 762948005484 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 762948005485 active site 762948005486 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 762948005487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762948005488 NAD(P) binding site [chemical binding]; other site 762948005489 active site 762948005490 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 762948005491 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762948005492 active site 762948005493 HIGH motif; other site 762948005494 nucleotide binding site [chemical binding]; other site 762948005495 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762948005496 active site 762948005497 KMSKS motif; other site 762948005498 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 762948005499 tRNA binding surface [nucleotide binding]; other site 762948005500 anticodon binding site; other site 762948005501 LssY C-terminus; Region: LssY_C; pfam14067 762948005502 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 762948005503 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 762948005504 catalytic residues [active] 762948005505 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 762948005506 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 762948005507 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 762948005508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762948005509 Walker A motif; other site 762948005510 ATP binding site [chemical binding]; other site 762948005511 Walker B motif; other site 762948005512 arginine finger; other site 762948005513 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 762948005514 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 762948005515 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 762948005516 oligomer interface [polypeptide binding]; other site 762948005517 active site residues [active] 762948005518 Clp protease; Region: CLP_protease; pfam00574 762948005519 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 762948005520 oligomer interface [polypeptide binding]; other site 762948005521 active site residues [active] 762948005522 trigger factor; Provisional; Region: tig; PRK01490 762948005523 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 762948005524 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 762948005525 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 762948005526 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 762948005527 putative DNA binding site [nucleotide binding]; other site 762948005528 catalytic residue [active] 762948005529 putative H2TH interface [polypeptide binding]; other site 762948005530 putative catalytic residues [active] 762948005531 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 762948005532 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 762948005533 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 762948005534 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 762948005535 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 762948005536 Zn binding site [ion binding]; other site 762948005537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762948005538 Coenzyme A binding pocket [chemical binding]; other site 762948005539 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 762948005540 apolar tunnel; other site 762948005541 heme binding site [chemical binding]; other site 762948005542 dimerization interface [polypeptide binding]; other site 762948005543 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 762948005544 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 762948005545 active site 762948005546 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 762948005547 catalytic triad [active] 762948005548 dimer interface [polypeptide binding]; other site 762948005549 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 762948005550 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 762948005551 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 762948005552 CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764 762948005553 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 762948005554 CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165 762948005555 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 762948005556 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 762948005557 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762948005558 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762948005559 ABC transporter; Region: ABC_tran_2; pfam12848 762948005560 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762948005561 Protein of unknown function (DUF419); Region: DUF419; cl15265 762948005562 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 762948005563 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 762948005564 RimM N-terminal domain; Region: RimM; pfam01782 762948005565 hypothetical protein; Provisional; Region: PRK02821 762948005566 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 762948005567 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 762948005568 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 762948005569 nudix motif; other site 762948005570 signal recognition particle protein; Provisional; Region: PRK10867 762948005571 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 762948005572 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 762948005573 P loop; other site 762948005574 GTP binding site [chemical binding]; other site 762948005575 Signal peptide binding domain; Region: SRP_SPB; pfam02978 762948005576 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 762948005577 nudix motif; other site 762948005578 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 762948005579 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 762948005580 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762948005581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948005582 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762948005583 putative substrate translocation pore; other site 762948005584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762948005585 putative substrate translocation pore; other site 762948005586 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 762948005587 AAA domain; Region: AAA_23; pfam13476 762948005588 Walker A/P-loop; other site 762948005589 ATP binding site [chemical binding]; other site 762948005590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948005591 ABC transporter signature motif; other site 762948005592 Walker B; other site 762948005593 D-loop; other site 762948005594 H-loop/switch region; other site 762948005595 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 762948005596 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 762948005597 active site 762948005598 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762948005599 peptide synthase; Provisional; Region: PRK09274 762948005600 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762948005601 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762948005602 acyl-activating enzyme (AAE) consensus motif; other site 762948005603 AMP binding site [chemical binding]; other site 762948005604 active site 762948005605 CoA binding site [chemical binding]; other site 762948005606 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 762948005607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762948005608 NAD(P) binding site [chemical binding]; other site 762948005609 active site 762948005610 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 762948005611 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 762948005612 DNA binding site [nucleotide binding] 762948005613 catalytic residue [active] 762948005614 H2TH interface [polypeptide binding]; other site 762948005615 putative catalytic residues [active] 762948005616 turnover-facilitating residue; other site 762948005617 intercalation triad [nucleotide binding]; other site 762948005618 8OG recognition residue [nucleotide binding]; other site 762948005619 putative reading head residues; other site 762948005620 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 762948005621 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 762948005622 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 762948005623 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 762948005624 dimerization interface [polypeptide binding]; other site 762948005625 active site 762948005626 metal binding site [ion binding]; metal-binding site 762948005627 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 762948005628 dsRNA binding site [nucleotide binding]; other site 762948005629 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 762948005630 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 762948005631 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 762948005632 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 762948005633 active site 762948005634 (T/H)XGH motif; other site 762948005635 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 762948005636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762948005637 S-adenosylmethionine binding site [chemical binding]; other site 762948005638 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 762948005639 ssDNA binding site; other site 762948005640 generic binding surface II; other site 762948005641 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762948005642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762948005643 ATP binding site [chemical binding]; other site 762948005644 putative Mg++ binding site [ion binding]; other site 762948005645 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 762948005646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762948005647 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 762948005648 nucleotide binding region [chemical binding]; other site 762948005649 ATP-binding site [chemical binding]; other site 762948005650 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 762948005651 thiamine monophosphate kinase; Provisional; Region: PRK05731 762948005652 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 762948005653 ATP binding site [chemical binding]; other site 762948005654 dimerization interface [polypeptide binding]; other site 762948005655 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 762948005656 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 762948005657 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 762948005658 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 762948005659 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 762948005660 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 762948005661 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 762948005662 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 762948005663 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 762948005664 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762948005665 putative acyl-acceptor binding pocket; other site 762948005666 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 762948005667 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 762948005668 hinge; other site 762948005669 active site 762948005670 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 762948005671 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 762948005672 substrate binding site [chemical binding]; other site 762948005673 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 762948005674 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 762948005675 substrate binding site [chemical binding]; other site 762948005676 ligand binding site [chemical binding]; other site 762948005677 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762948005678 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762948005679 Bacterial transcriptional regulator; Region: IclR; pfam01614 762948005680 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 762948005681 G1 box; other site 762948005682 GTP/Mg2+ binding site [chemical binding]; other site 762948005683 G2 box; other site 762948005684 Switch I region; other site 762948005685 G3 box; other site 762948005686 Switch II region; other site 762948005687 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 762948005688 Switch II region; other site 762948005689 G4 box; other site 762948005690 G5 box; other site 762948005691 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 762948005692 G1 box; other site 762948005693 GTP/Mg2+ binding site [chemical binding]; other site 762948005694 G2 box; other site 762948005695 Switch I region; other site 762948005696 G3 box; other site 762948005697 Switch II region; other site 762948005698 G4 box; other site 762948005699 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 762948005700 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 762948005701 dimer interface [polypeptide binding]; other site 762948005702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762948005703 catalytic residue [active] 762948005704 serine O-acetyltransferase; Region: cysE; TIGR01172 762948005705 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 762948005706 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 762948005707 trimer interface [polypeptide binding]; other site 762948005708 active site 762948005709 substrate binding site [chemical binding]; other site 762948005710 CoA binding site [chemical binding]; other site 762948005711 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762948005712 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 762948005713 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 762948005714 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 762948005715 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 762948005716 dimer interface [polypeptide binding]; other site 762948005717 TPP-binding site [chemical binding]; other site 762948005718 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 762948005719 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 762948005720 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 762948005721 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 762948005722 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 762948005723 acyl-activating enzyme (AAE) consensus motif; other site 762948005724 AMP binding site [chemical binding]; other site 762948005725 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 762948005726 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 762948005727 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 762948005728 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 762948005729 acyl-activating enzyme (AAE) consensus motif; other site 762948005730 active site 762948005731 AMP binding site [chemical binding]; other site 762948005732 substrate binding site [chemical binding]; other site 762948005733 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 762948005734 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 762948005735 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 762948005736 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762948005737 Walker A/P-loop; other site 762948005738 ATP binding site [chemical binding]; other site 762948005739 Q-loop/lid; other site 762948005740 ABC transporter signature motif; other site 762948005741 Walker B; other site 762948005742 D-loop; other site 762948005743 H-loop/switch region; other site 762948005744 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 762948005745 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762948005746 ABC-ATPase subunit interface; other site 762948005747 dimer interface [polypeptide binding]; other site 762948005748 putative PBP binding regions; other site 762948005749 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 762948005750 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 762948005751 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762948005752 ABC-ATPase subunit interface; other site 762948005753 dimer interface [polypeptide binding]; other site 762948005754 putative PBP binding regions; other site 762948005755 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 762948005756 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 762948005757 siderophore binding site; other site 762948005758 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 762948005759 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 762948005760 substrate binding site [chemical binding]; other site 762948005761 hexamer interface [polypeptide binding]; other site 762948005762 metal binding site [ion binding]; metal-binding site 762948005763 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 762948005764 putative RNA binding site [nucleotide binding]; other site 762948005765 16S rRNA methyltransferase B; Provisional; Region: PRK14902 762948005766 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 762948005767 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 762948005768 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 762948005769 putative active site [active] 762948005770 substrate binding site [chemical binding]; other site 762948005771 putative cosubstrate binding site; other site 762948005772 catalytic site [active] 762948005773 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 762948005774 substrate binding site [chemical binding]; other site 762948005775 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 762948005776 active site 762948005777 catalytic residues [active] 762948005778 metal binding site [ion binding]; metal-binding site 762948005779 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 762948005780 Uncharacterized conserved protein [Function unknown]; Region: COG3391 762948005781 S-layer homology domain; Region: SLH; pfam00395 762948005782 S-layer homology domain; Region: SLH; pfam00395 762948005783 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 762948005784 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762948005785 HIGH motif; other site 762948005786 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762948005787 active site 762948005788 KMSKS motif; other site 762948005789 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 762948005790 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 762948005791 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762948005792 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 762948005793 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 762948005794 homodimer interface [polypeptide binding]; other site 762948005795 substrate-cofactor binding pocket; other site 762948005796 catalytic residue [active] 762948005797 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 762948005798 tartrate dehydrogenase; Region: TTC; TIGR02089 762948005799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 762948005800 Histidine kinase; Region: HisKA_3; pfam07730 762948005801 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 762948005802 ATP binding site [chemical binding]; other site 762948005803 Mg2+ binding site [ion binding]; other site 762948005804 G-X-G motif; other site 762948005805 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762948005806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762948005807 active site 762948005808 phosphorylation site [posttranslational modification] 762948005809 intermolecular recognition site; other site 762948005810 dimerization interface [polypeptide binding]; other site 762948005811 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762948005812 DNA binding residues [nucleotide binding] 762948005813 dimerization interface [polypeptide binding]; other site 762948005814 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762948005815 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 762948005816 FtsX-like permease family; Region: FtsX; pfam02687 762948005817 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 762948005818 FtsX-like permease family; Region: FtsX; pfam02687 762948005819 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762948005820 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762948005821 Walker A/P-loop; other site 762948005822 ATP binding site [chemical binding]; other site 762948005823 Q-loop/lid; other site 762948005824 ABC transporter signature motif; other site 762948005825 Walker B; other site 762948005826 D-loop; other site 762948005827 H-loop/switch region; other site 762948005828 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762948005829 FtsX-like permease family; Region: FtsX; pfam02687 762948005830 FtsX-like permease family; Region: FtsX; pfam02687 762948005831 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762948005832 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762948005833 Walker A/P-loop; other site 762948005834 ATP binding site [chemical binding]; other site 762948005835 Q-loop/lid; other site 762948005836 ABC transporter signature motif; other site 762948005837 Walker B; other site 762948005838 D-loop; other site 762948005839 H-loop/switch region; other site 762948005840 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762948005841 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 762948005842 FtsX-like permease family; Region: FtsX; pfam02687 762948005843 FtsX-like permease family; Region: FtsX; pfam02687 762948005844 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 762948005845 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 762948005846 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 762948005847 active site 762948005848 HIGH motif; other site 762948005849 KMSKS motif; other site 762948005850 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 762948005851 tRNA binding surface [nucleotide binding]; other site 762948005852 anticodon binding site; other site 762948005853 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 762948005854 ketol-acid reductoisomerase; Provisional; Region: PRK05479 762948005855 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 762948005856 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 762948005857 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 762948005858 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 762948005859 putative valine binding site [chemical binding]; other site 762948005860 dimer interface [polypeptide binding]; other site 762948005861 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 762948005862 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 762948005863 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762948005864 PYR/PP interface [polypeptide binding]; other site 762948005865 dimer interface [polypeptide binding]; other site 762948005866 TPP binding site [chemical binding]; other site 762948005867 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762948005868 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 762948005869 TPP-binding site [chemical binding]; other site 762948005870 dimer interface [polypeptide binding]; other site 762948005871 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 762948005872 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 762948005873 catalytic triad [active] 762948005874 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762948005875 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 762948005876 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762948005877 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 762948005878 malate:quinone oxidoreductase; Validated; Region: PRK05257 762948005879 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 762948005880 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 762948005881 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 762948005882 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762948005883 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 762948005884 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 762948005885 NAD binding site [chemical binding]; other site 762948005886 catalytic Zn binding site [ion binding]; other site 762948005887 substrate binding site [chemical binding]; other site 762948005888 structural Zn binding site [ion binding]; other site 762948005889 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762948005890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948005891 AAA domain; Region: AAA_23; pfam13476 762948005892 Walker A/P-loop; other site 762948005893 ATP binding site [chemical binding]; other site 762948005894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948005895 Q-loop/lid; other site 762948005896 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 762948005897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762948005898 Walker B; other site 762948005899 D-loop; other site 762948005900 H-loop/switch region; other site 762948005901 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 762948005902 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762948005903 active site 762948005904 metal binding site [ion binding]; metal-binding site 762948005905 DNA binding site [nucleotide binding] 762948005906 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 762948005907 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 762948005908 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 762948005909 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234