-- dump date 20140620_041625 -- class Genbank::misc_feature -- table misc_feature_note -- id note 680646000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 680646000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 680646000003 Walker A motif; other site 680646000004 ATP binding site [chemical binding]; other site 680646000005 Walker B motif; other site 680646000006 arginine finger; other site 680646000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 680646000008 DnaA box-binding interface [nucleotide binding]; other site 680646000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 680646000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 680646000011 putative DNA binding surface [nucleotide binding]; other site 680646000012 dimer interface [polypeptide binding]; other site 680646000013 beta-clamp/clamp loader binding surface; other site 680646000014 beta-clamp/translesion DNA polymerase binding surface; other site 680646000015 recombination protein F; Reviewed; Region: recF; PRK00064 680646000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 680646000017 Walker A/P-loop; other site 680646000018 ATP binding site [chemical binding]; other site 680646000019 Q-loop/lid; other site 680646000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646000021 ABC transporter signature motif; other site 680646000022 Walker B; other site 680646000023 D-loop; other site 680646000024 H-loop/switch region; other site 680646000025 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 680646000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 680646000027 Mg2+ binding site [ion binding]; other site 680646000028 G-X-G motif; other site 680646000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 680646000030 anchoring element; other site 680646000031 dimer interface [polypeptide binding]; other site 680646000032 ATP binding site [chemical binding]; other site 680646000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 680646000034 active site 680646000035 putative metal-binding site [ion binding]; other site 680646000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 680646000037 DNA gyrase subunit A; Validated; Region: PRK05560 680646000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 680646000039 CAP-like domain; other site 680646000040 active site 680646000041 primary dimer interface [polypeptide binding]; other site 680646000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 680646000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 680646000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 680646000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 680646000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 680646000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 680646000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 680646000049 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 680646000050 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 680646000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 680646000052 active site 680646000053 Rhomboid family; Region: Rhomboid; pfam01694 680646000054 Rhomboid family; Region: Rhomboid; pfam01694 680646000055 potential protein location (hypothetical protein) that overlaps protein (shikimate 5-dehydrogenase) 680646000056 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 680646000057 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 680646000058 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 680646000059 shikimate binding site; other site 680646000060 NAD(P) binding site [chemical binding]; other site 680646000061 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 680646000062 catalytic residues [active] 680646000063 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 680646000064 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 680646000065 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 680646000066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 680646000067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 680646000068 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 680646000069 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 680646000070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 680646000071 active site 680646000072 motif I; other site 680646000073 motif II; other site 680646000074 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 680646000075 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 680646000076 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 680646000077 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 680646000078 active pocket/dimerization site; other site 680646000079 active site 680646000080 phosphorylation site [posttranslational modification] 680646000081 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 680646000082 active site 680646000083 phosphorylation site [posttranslational modification] 680646000084 transcriptional antiterminator BglG; Provisional; Region: PRK09772 680646000085 CAT RNA binding domain; Region: CAT_RBD; smart01061 680646000086 PRD domain; Region: PRD; pfam00874 680646000087 PRD domain; Region: PRD; pfam00874 680646000088 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 680646000089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 680646000090 active site 680646000091 phosphorylation site [posttranslational modification] 680646000092 intermolecular recognition site; other site 680646000093 dimerization interface [polypeptide binding]; other site 680646000094 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 680646000095 DNA binding site [nucleotide binding] 680646000096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 680646000097 HAMP domain; Region: HAMP; pfam00672 680646000098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 680646000099 dimer interface [polypeptide binding]; other site 680646000100 phosphorylation site [posttranslational modification] 680646000101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 680646000102 ATP binding site [chemical binding]; other site 680646000103 Mg2+ binding site [ion binding]; other site 680646000104 G-X-G motif; other site 680646000105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 680646000106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 680646000107 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 680646000108 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 680646000109 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 680646000110 CrcB-like protein; Region: CRCB; pfam02537 680646000111 CrcB-like protein; Region: CRCB; pfam02537 680646000112 VanZ like family; Region: VanZ; pfam04892 680646000113 potential protein location (hypothetical protein) that overlaps protein (glycerol uptake facilitator) 680646000114 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 680646000115 amphipathic channel; other site 680646000116 Asn-Pro-Ala signature motifs; other site 680646000117 acetylornithine deacetylase; Provisional; Region: PRK07522 680646000118 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 680646000119 metal binding site [ion binding]; metal-binding site 680646000120 putative dimer interface [polypeptide binding]; other site 680646000121 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 680646000122 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 680646000123 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 680646000124 Ligand binding site; other site 680646000125 Putative Catalytic site; other site 680646000126 DXD motif; other site 680646000127 Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066 680646000128 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 680646000129 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 680646000130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646000131 metabolite-proton symporter; Region: 2A0106; TIGR00883 680646000132 putative substrate translocation pore; other site 680646000133 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 680646000134 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 680646000135 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 680646000136 shikimate binding site; other site 680646000137 NAD(P) binding site [chemical binding]; other site 680646000138 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 680646000139 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 680646000140 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 680646000141 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 680646000142 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 680646000143 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 680646000144 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 680646000145 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 680646000146 putative substrate binding site [chemical binding]; other site 680646000147 putative ATP binding site [chemical binding]; other site 680646000148 potential protein location (hypothetical protein) that overlaps protein (phospholipid-binding protein) 680646000149 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 680646000150 substrate binding site [chemical binding]; other site 680646000151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 680646000152 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 680646000153 active site 680646000154 motif I; other site 680646000155 motif II; other site 680646000156 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 680646000157 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 680646000158 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 680646000159 active site 680646000160 potential protein location (hypothetical protein) that overlaps protein (ABC-type dipeptide/oligopeptide/nickel transport system, permease component) 680646000161 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 680646000162 Fic family protein [Function unknown]; Region: COG3177 680646000163 Fic/DOC family; Region: Fic; pfam02661 680646000164 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 680646000165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646000166 putative substrate translocation pore; other site 680646000167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646000168 potential protein location (hypothetical protein) that overlaps protein (rhodanese-related sulfurtransferase) 680646000169 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 680646000170 active site residue [active] 680646000171 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 680646000172 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 680646000173 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 680646000174 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 680646000175 active site 680646000176 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 680646000177 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 680646000178 ornithine cyclodeaminase; Validated; Region: PRK07589 680646000179 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 680646000180 L-asparagine permease; Provisional; Region: PRK15049 680646000181 galactokinase; Provisional; Region: PRK05101 680646000182 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 680646000183 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 680646000184 active site 680646000185 intersubunit interface [polypeptide binding]; other site 680646000186 zinc binding site [ion binding]; other site 680646000187 Na+ binding site [ion binding]; other site 680646000188 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 680646000189 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 680646000190 HPr interaction site; other site 680646000191 glycerol kinase (GK) interaction site [polypeptide binding]; other site 680646000192 active site 680646000193 phosphorylation site [posttranslational modification] 680646000194 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 680646000195 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 680646000196 active site 680646000197 catalytic site [active] 680646000198 metal binding site [ion binding]; metal-binding site 680646000199 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 680646000200 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 680646000201 tetramerization interface [polypeptide binding]; other site 680646000202 NAD(P) binding site [chemical binding]; other site 680646000203 catalytic residues [active] 680646000204 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 680646000205 putative dimer interface [polypeptide binding]; other site 680646000206 putative [2Fe-2S] cluster binding site [ion binding]; other site 680646000207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 680646000208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 680646000209 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 680646000210 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 680646000211 RNA binding surface [nucleotide binding]; other site 680646000212 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 680646000213 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 680646000214 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 680646000215 dimer interface [polypeptide binding]; other site 680646000216 FMN binding site [chemical binding]; other site 680646000217 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 680646000218 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 680646000219 metal-binding site [ion binding] 680646000220 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 680646000221 Soluble P-type ATPase [General function prediction only]; Region: COG4087 680646000222 potential protein location (hypothetical protein) that overlaps protein (asparagine synthase) 680646000223 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 680646000224 putative homodimer interface [polypeptide binding]; other site 680646000225 putative homotetramer interface [polypeptide binding]; other site 680646000226 putative allosteric switch controlling residues; other site 680646000227 putative metal binding site [ion binding]; other site 680646000228 putative homodimer-homodimer interface [polypeptide binding]; other site 680646000229 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 680646000230 putative active site [active] 680646000231 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 680646000232 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 680646000233 cofactor binding site; other site 680646000234 DNA binding site [nucleotide binding] 680646000235 substrate interaction site [chemical binding]; other site 680646000236 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 680646000237 HNH endonuclease; Region: HNH_2; pfam13391 680646000238 phosphate acetyltransferase; Reviewed; Region: PRK05632 680646000239 DRTGG domain; Region: DRTGG; pfam07085 680646000240 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 680646000241 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 680646000242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 680646000243 prephenate dehydratase; Provisional; Region: PRK11898 680646000244 Prephenate dehydratase; Region: PDT; pfam00800 680646000245 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 680646000246 putative L-Phe binding site [chemical binding]; other site 680646000247 seryl-tRNA synthetase; Provisional; Region: PRK05431 680646000248 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 680646000249 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 680646000250 dimer interface [polypeptide binding]; other site 680646000251 active site 680646000252 motif 1; other site 680646000253 motif 2; other site 680646000254 motif 3; other site 680646000255 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 680646000256 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 680646000257 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 680646000258 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 680646000259 Fic/DOC family; Region: Fic; cl00960 680646000260 potential protein location (hypothetical protein) that overlaps protein (Rhs family protein) 680646000261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 680646000262 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 680646000263 FIC domain binding interface [polypeptide binding]; other site 680646000264 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 680646000265 Fic/DOC family; Region: Fic; cl00960 680646000266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646000267 ABC transporter signature motif; other site 680646000268 Walker B; other site 680646000269 D-loop; other site 680646000270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646000271 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 680646000272 Walker A/P-loop; other site 680646000273 ATP binding site [chemical binding]; other site 680646000274 ABC transporter signature motif; other site 680646000275 Walker B; other site 680646000276 D-loop; other site 680646000277 H-loop/switch region; other site 680646000278 propionate/acetate kinase; Provisional; Region: PRK12379 680646000279 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 680646000280 Peptidase family M48; Region: Peptidase_M48; cl12018 680646000281 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 680646000282 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 680646000283 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 680646000284 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 680646000285 S-layer homology domain; Region: SLH; pfam00395 680646000286 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 680646000287 putative catalytic site [active] 680646000288 putative phosphate binding site [ion binding]; other site 680646000289 active site 680646000290 metal binding site A [ion binding]; metal-binding site 680646000291 DNA binding site [nucleotide binding] 680646000292 putative AP binding site [nucleotide binding]; other site 680646000293 putative metal binding site B [ion binding]; other site 680646000294 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 680646000295 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 680646000296 metal binding site [ion binding]; metal-binding site 680646000297 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 680646000298 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 680646000299 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 680646000300 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 680646000301 ABC-ATPase subunit interface; other site 680646000302 dimer interface [polypeptide binding]; other site 680646000303 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 680646000304 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 680646000305 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 680646000306 FeoA domain; Region: FeoA; pfam04023 680646000307 H+ Antiporter protein; Region: 2A0121; TIGR00900 680646000308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646000309 putative substrate translocation pore; other site 680646000310 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 680646000311 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 680646000312 ATP binding site [chemical binding]; other site 680646000313 substrate interface [chemical binding]; other site 680646000314 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 680646000315 Part of AAA domain; Region: AAA_19; pfam13245 680646000316 AAA domain; Region: AAA_12; pfam13087 680646000317 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 680646000318 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 680646000319 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 680646000320 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 680646000321 dimer interface [polypeptide binding]; other site 680646000322 substrate binding site [chemical binding]; other site 680646000323 metal binding sites [ion binding]; metal-binding site 680646000324 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 680646000325 Ligand Binding Site [chemical binding]; other site 680646000326 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 680646000327 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 680646000328 active site 680646000329 FtsH Extracellular; Region: FtsH_ext; pfam06480 680646000330 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 680646000331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 680646000332 Walker A motif; other site 680646000333 ATP binding site [chemical binding]; other site 680646000334 Walker B motif; other site 680646000335 arginine finger; other site 680646000336 Peptidase family M41; Region: Peptidase_M41; pfam01434 680646000337 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 680646000338 homodecamer interface [polypeptide binding]; other site 680646000339 GTP cyclohydrolase I; Provisional; Region: PLN03044 680646000340 active site 680646000341 putative catalytic site residues [active] 680646000342 zinc binding site [ion binding]; other site 680646000343 GTP-CH-I/GFRP interaction surface; other site 680646000344 Abi-like protein; Region: Abi_2; cl01988 680646000345 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 680646000346 dihydropteroate synthase; Region: DHPS; TIGR01496 680646000347 substrate binding pocket [chemical binding]; other site 680646000348 dimer interface [polypeptide binding]; other site 680646000349 inhibitor binding site; inhibition site 680646000350 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 680646000351 active site 680646000352 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 680646000353 catalytic center binding site [active] 680646000354 ATP binding site [chemical binding]; other site 680646000355 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 680646000356 Bacterial PH domain; Region: DUF304; cl01348 680646000357 Bacterial PH domain; Region: DUF304; pfam03703 680646000358 Predicted membrane protein [Function unknown]; Region: COG3428 680646000359 Bacterial PH domain; Region: DUF304; pfam03703 680646000360 Bacterial PH domain; Region: DUF304; pfam03703 680646000361 Rossmann-like domain; Region: Rossmann-like; pfam10727 680646000362 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 680646000363 Pantoate-beta-alanine ligase; Region: PanC; cd00560 680646000364 pantoate--beta-alanine ligase; Region: panC; TIGR00018 680646000365 active site 680646000366 ATP-binding site [chemical binding]; other site 680646000367 pantoate-binding site; other site 680646000368 HXXH motif; other site 680646000369 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 680646000370 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 680646000371 putative anticodon binding site; other site 680646000372 dimer interface [polypeptide binding]; other site 680646000373 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 680646000374 motif 1; other site 680646000375 dimer interface [polypeptide binding]; other site 680646000376 active site 680646000377 motif 2; other site 680646000378 motif 3; other site 680646000379 Lsr2; Region: Lsr2; pfam11774 680646000380 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 680646000381 Clp amino terminal domain; Region: Clp_N; pfam02861 680646000382 Clp amino terminal domain; Region: Clp_N; pfam02861 680646000383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 680646000384 Walker A motif; other site 680646000385 ATP binding site [chemical binding]; other site 680646000386 Walker B motif; other site 680646000387 arginine finger; other site 680646000388 UvrB/uvrC motif; Region: UVR; pfam02151 680646000389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 680646000390 Walker A motif; other site 680646000391 ATP binding site [chemical binding]; other site 680646000392 Walker B motif; other site 680646000393 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 680646000394 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 680646000395 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 680646000396 minor groove reading motif; other site 680646000397 helix-hairpin-helix signature motif; other site 680646000398 active site 680646000399 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 680646000400 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 680646000401 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 680646000402 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 680646000403 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 680646000404 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 680646000405 DNA repair protein RadA; Provisional; Region: PRK11823 680646000406 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 680646000407 Walker A motif; other site 680646000408 ATP binding site [chemical binding]; other site 680646000409 Walker B motif; other site 680646000410 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 680646000411 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 680646000412 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 680646000413 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 680646000414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 680646000415 active site 680646000416 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 680646000417 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 680646000418 active site 680646000419 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 680646000420 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 680646000421 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 680646000422 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 680646000423 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 680646000424 DEAD-like helicases superfamily; Region: DEXDc; smart00487 680646000425 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 680646000426 ATP binding site [chemical binding]; other site 680646000427 putative Mg++ binding site [ion binding]; other site 680646000428 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 680646000429 nucleotide binding region [chemical binding]; other site 680646000430 ATP-binding site [chemical binding]; other site 680646000431 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 680646000432 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 680646000433 nucleoside/Zn binding site; other site 680646000434 dimer interface [polypeptide binding]; other site 680646000435 catalytic motif [active] 680646000436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646000437 Walker A/P-loop; other site 680646000438 ATP binding site [chemical binding]; other site 680646000439 Q-loop/lid; other site 680646000440 ABC transporter signature motif; other site 680646000441 Walker B; other site 680646000442 Predicted membrane protein [Function unknown]; Region: COG1511 680646000443 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 680646000444 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 680646000445 Predicted membrane protein [Function unknown]; Region: COG1511 680646000446 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 680646000447 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 680646000448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 680646000449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 680646000450 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 680646000451 potential protein location (hypothetical protein RMDY18_01940 [Rothia mucilaginosa DY-18]) that overlaps RNA (tRNA-S) 680646000452 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 680646000453 active site 680646000454 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 680646000455 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 680646000456 DNA binding site [nucleotide binding] 680646000457 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 680646000458 catalytic core [active] 680646000459 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646000460 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646000461 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 680646000462 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 680646000463 NAD(P) binding site [chemical binding]; other site 680646000464 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 680646000465 Thioredoxin; Region: Thioredoxin_4; cl17273 680646000466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 680646000467 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 680646000468 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 680646000469 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 680646000470 adenylosuccinate lyase; Provisional; Region: PRK09285 680646000471 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 680646000472 tetramer interface [polypeptide binding]; other site 680646000473 active site 680646000474 Atrophin-1 family; Region: Atrophin-1; pfam03154 680646000475 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 680646000476 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 680646000477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646000478 homodimer interface [polypeptide binding]; other site 680646000479 catalytic residue [active] 680646000480 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 680646000481 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 680646000482 tetramer interface [polypeptide binding]; other site 680646000483 TPP-binding site [chemical binding]; other site 680646000484 heterodimer interface [polypeptide binding]; other site 680646000485 phosphorylation loop region [posttranslational modification] 680646000486 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 680646000487 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 680646000488 alpha subunit interface [polypeptide binding]; other site 680646000489 TPP binding site [chemical binding]; other site 680646000490 heterodimer interface [polypeptide binding]; other site 680646000491 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 680646000492 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 680646000493 E3 interaction surface; other site 680646000494 lipoyl attachment site [posttranslational modification]; other site 680646000495 e3 binding domain; Region: E3_binding; pfam02817 680646000496 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 680646000497 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 680646000498 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 680646000499 maltose O-acetyltransferase; Provisional; Region: PRK10092 680646000500 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 680646000501 trimer interface [polypeptide binding]; other site 680646000502 active site 680646000503 substrate binding site [chemical binding]; other site 680646000504 CoA binding site [chemical binding]; other site 680646000505 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 680646000506 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 680646000507 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 680646000508 acyl-activating enzyme (AAE) consensus motif; other site 680646000509 AMP binding site [chemical binding]; other site 680646000510 active site 680646000511 CoA binding site [chemical binding]; other site 680646000512 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 680646000513 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 680646000514 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 680646000515 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 680646000516 Walker A/P-loop; other site 680646000517 ATP binding site [chemical binding]; other site 680646000518 Q-loop/lid; other site 680646000519 ABC transporter signature motif; other site 680646000520 Walker B; other site 680646000521 D-loop; other site 680646000522 H-loop/switch region; other site 680646000523 NIL domain; Region: NIL; cl09633 680646000524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 680646000525 dimer interface [polypeptide binding]; other site 680646000526 conserved gate region; other site 680646000527 putative PBP binding loops; other site 680646000528 ABC-ATPase subunit interface; other site 680646000529 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 680646000530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 680646000531 motif II; other site 680646000532 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 680646000533 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 680646000534 Walker A/P-loop; other site 680646000535 ATP binding site [chemical binding]; other site 680646000536 Q-loop/lid; other site 680646000537 ABC transporter signature motif; other site 680646000538 Walker B; other site 680646000539 D-loop; other site 680646000540 H-loop/switch region; other site 680646000541 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 680646000542 catalytic core [active] 680646000543 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 680646000544 catalytic core [active] 680646000545 VanZ like family; Region: VanZ; cl01971 680646000546 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 680646000547 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 680646000548 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 680646000549 potential protein location (hypothetical protein) that overlaps protein (fructose-1-phosphate kinase) 680646000550 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 680646000551 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 680646000552 putative substrate binding site [chemical binding]; other site 680646000553 putative ATP binding site [chemical binding]; other site 680646000554 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 680646000555 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 680646000556 active site 680646000557 phosphorylation site [posttranslational modification] 680646000558 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 680646000559 active site 680646000560 P-loop; other site 680646000561 phosphorylation site [posttranslational modification] 680646000562 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 680646000563 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 680646000564 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 680646000565 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 680646000566 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 680646000567 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 680646000568 dimerization domain swap beta strand [polypeptide binding]; other site 680646000569 regulatory protein interface [polypeptide binding]; other site 680646000570 active site 680646000571 regulatory phosphorylation site [posttranslational modification]; other site 680646000572 Uncharacterized conserved protein [Function unknown]; Region: COG2966 680646000573 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 680646000574 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 680646000575 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 680646000576 ligand binding site [chemical binding]; other site 680646000577 active site 680646000578 UGI interface [polypeptide binding]; other site 680646000579 catalytic site [active] 680646000580 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 680646000581 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 680646000582 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 680646000583 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 680646000584 ring oligomerisation interface [polypeptide binding]; other site 680646000585 ATP/Mg binding site [chemical binding]; other site 680646000586 stacking interactions; other site 680646000587 hinge regions; other site 680646000588 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 680646000589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 680646000590 S-adenosylmethionine binding site [chemical binding]; other site 680646000591 H+ Antiporter protein; Region: 2A0121; TIGR00900 680646000592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646000593 DinB superfamily; Region: DinB_2; pfam12867 680646000594 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 680646000595 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 680646000596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 680646000597 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 680646000598 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 680646000599 Isochorismatase family; Region: Isochorismatase; pfam00857 680646000600 catalytic triad [active] 680646000601 conserved cis-peptide bond; other site 680646000602 potential protein location (hypothetical protein) that overlaps protein (dehydrogenase) 680646000603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 680646000604 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 680646000605 NAD(P) binding site [chemical binding]; other site 680646000606 active site 680646000607 isochorismate synthase DhbC; Validated; Region: PRK06923 680646000608 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 680646000609 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 680646000610 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 680646000611 RNA/DNA hybrid binding site [nucleotide binding]; other site 680646000612 active site 680646000613 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 680646000614 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 680646000615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 680646000616 dimerization interface [polypeptide binding]; other site 680646000617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 680646000618 dimer interface [polypeptide binding]; other site 680646000619 phosphorylation site [posttranslational modification] 680646000620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 680646000621 ATP binding site [chemical binding]; other site 680646000622 Mg2+ binding site [ion binding]; other site 680646000623 G-X-G motif; other site 680646000624 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 680646000625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 680646000626 active site 680646000627 phosphorylation site [posttranslational modification] 680646000628 intermolecular recognition site; other site 680646000629 dimerization interface [polypeptide binding]; other site 680646000630 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 680646000631 DNA binding site [nucleotide binding] 680646000632 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 680646000633 potential protein location (hypothetical protein) that overlaps protein (acyl-CoA dehydrogenase) 680646000634 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 680646000635 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 680646000636 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 680646000637 FeoA domain; Region: FeoA; pfam04023 680646000638 NlpC/P60 family; Region: NLPC_P60; pfam00877 680646000639 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 680646000640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 680646000641 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 680646000642 Part of AAA domain; Region: AAA_19; pfam13245 680646000643 Family description; Region: UvrD_C_2; pfam13538 680646000644 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 680646000645 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 680646000646 CoA-ligase; Region: Ligase_CoA; pfam00549 680646000647 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 680646000648 CoA binding domain; Region: CoA_binding; smart00881 680646000649 CoA binding domain; Region: CoA_binding; cl17356 680646000650 CoA-ligase; Region: Ligase_CoA; pfam00549 680646000651 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 680646000652 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 680646000653 diiron binding motif [ion binding]; other site 680646000654 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 680646000655 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 680646000656 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 680646000657 dimerization interface [polypeptide binding]; other site 680646000658 DPS ferroxidase diiron center [ion binding]; other site 680646000659 ion pore; other site 680646000660 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 680646000661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 680646000662 motif II; other site 680646000663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 680646000664 NADH(P)-binding; Region: NAD_binding_10; pfam13460 680646000665 NAD(P) binding site [chemical binding]; other site 680646000666 active site 680646000667 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 680646000668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 680646000669 Walker A motif; other site 680646000670 ATP binding site [chemical binding]; other site 680646000671 Walker B motif; other site 680646000672 arginine finger; other site 680646000673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 680646000674 Walker A motif; other site 680646000675 ATP binding site [chemical binding]; other site 680646000676 Walker B motif; other site 680646000677 arginine finger; other site 680646000678 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 680646000679 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 680646000680 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 680646000681 Excalibur calcium-binding domain; Region: Excalibur; smart00894 680646000682 Excalibur calcium-binding domain; Region: Excalibur; smart00894 680646000683 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 680646000684 putative metal binding residues [ion binding]; other site 680646000685 signature motif; other site 680646000686 dimer interface [polypeptide binding]; other site 680646000687 active site 680646000688 polyP binding site; other site 680646000689 substrate binding site [chemical binding]; other site 680646000690 acceptor-phosphate pocket; other site 680646000691 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 680646000692 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 680646000693 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 680646000694 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 680646000695 Predicted periplasmic protein [Function unknown]; Region: COG3698 680646000696 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 680646000697 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 680646000698 Ligand binding site; other site 680646000699 Putative Catalytic site; other site 680646000700 DXD motif; other site 680646000701 GtrA-like protein; Region: GtrA; pfam04138 680646000702 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 680646000703 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 680646000704 active site 680646000705 catalytic triad [active] 680646000706 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 680646000707 active site 680646000708 catalytic triad [active] 680646000709 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 680646000710 active site 680646000711 catalytic triad [active] 680646000712 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 680646000713 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 680646000714 dimerization interface [polypeptide binding]; other site 680646000715 putative ATP binding site [chemical binding]; other site 680646000716 amidophosphoribosyltransferase; Provisional; Region: PRK07847 680646000717 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 680646000718 active site 680646000719 tetramer interface [polypeptide binding]; other site 680646000720 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 680646000721 active site 680646000722 L-asparaginase II; Region: Asparaginase_II; cl01842 680646000723 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 680646000724 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 680646000725 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 680646000726 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 680646000727 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 680646000728 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 680646000729 ATP binding site [chemical binding]; other site 680646000730 active site 680646000731 substrate binding site [chemical binding]; other site 680646000732 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 680646000733 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 680646000734 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 680646000735 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 680646000736 Walker A/P-loop; other site 680646000737 ATP binding site [chemical binding]; other site 680646000738 Q-loop/lid; other site 680646000739 ABC transporter signature motif; other site 680646000740 Walker B; other site 680646000741 D-loop; other site 680646000742 H-loop/switch region; other site 680646000743 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 680646000744 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 680646000745 FtsX-like permease family; Region: FtsX; pfam02687 680646000746 Transcriptional regulators [Transcription]; Region: FadR; COG2186 680646000747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 680646000748 DNA-binding site [nucleotide binding]; DNA binding site 680646000749 FCD domain; Region: FCD; pfam07729 680646000750 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 680646000751 L-lactate permease; Region: Lactate_perm; cl00701 680646000752 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 680646000753 Cysteine-rich domain; Region: CCG; pfam02754 680646000754 Cysteine-rich domain; Region: CCG; pfam02754 680646000755 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 680646000756 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 680646000757 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 680646000758 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 680646000759 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 680646000760 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 680646000761 Moco binding site; other site 680646000762 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 680646000763 metal coordination site [ion binding]; other site 680646000764 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 680646000765 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 680646000766 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 680646000767 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 680646000768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646000769 Walker A/P-loop; other site 680646000770 ATP binding site [chemical binding]; other site 680646000771 Q-loop/lid; other site 680646000772 ABC transporter signature motif; other site 680646000773 Walker B; other site 680646000774 D-loop; other site 680646000775 H-loop/switch region; other site 680646000776 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 680646000777 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 680646000778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646000779 Walker A/P-loop; other site 680646000780 ATP binding site [chemical binding]; other site 680646000781 Q-loop/lid; other site 680646000782 ABC transporter signature motif; other site 680646000783 Walker B; other site 680646000784 D-loop; other site 680646000785 H-loop/switch region; other site 680646000786 phosphodiesterase YaeI; Provisional; Region: PRK11340 680646000787 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 680646000788 active site 680646000789 metal binding site [ion binding]; metal-binding site 680646000790 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 680646000791 Transglycosylase; Region: Transgly; pfam00912 680646000792 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 680646000793 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 680646000794 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 680646000795 homotrimer interaction site [polypeptide binding]; other site 680646000796 putative active site [active] 680646000797 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 680646000798 nudix motif; other site 680646000799 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 680646000800 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 680646000801 ligand binding site [chemical binding]; other site 680646000802 flexible hinge region; other site 680646000803 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 680646000804 non-specific DNA interactions [nucleotide binding]; other site 680646000805 DNA binding site [nucleotide binding] 680646000806 sequence specific DNA binding site [nucleotide binding]; other site 680646000807 putative cAMP binding site [chemical binding]; other site 680646000808 Colicin V production protein; Region: Colicin_V; pfam02674 680646000809 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 680646000810 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 680646000811 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 680646000812 Dehydroquinase class II; Region: DHquinase_II; pfam01220 680646000813 trimer interface [polypeptide binding]; other site 680646000814 active site 680646000815 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 680646000816 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 680646000817 minor groove reading motif; other site 680646000818 helix-hairpin-helix signature motif; other site 680646000819 substrate binding pocket [chemical binding]; other site 680646000820 active site 680646000821 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 680646000822 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 680646000823 putative active site [active] 680646000824 putative CoA binding site [chemical binding]; other site 680646000825 nudix motif; other site 680646000826 metal binding site [ion binding]; metal-binding site 680646000827 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 680646000828 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 680646000829 active site 680646000830 DNA binding site [nucleotide binding] 680646000831 catalytic site [active] 680646000832 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 680646000833 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 680646000834 Walker A motif; other site 680646000835 ATP binding site [chemical binding]; other site 680646000836 Walker B motif; other site 680646000837 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 680646000838 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 680646000839 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 680646000840 ATP binding site [chemical binding]; other site 680646000841 putative Mg++ binding site [ion binding]; other site 680646000842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 680646000843 nucleotide binding region [chemical binding]; other site 680646000844 ATP-binding site [chemical binding]; other site 680646000845 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 680646000846 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 680646000847 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 680646000848 active site residue [active] 680646000849 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 680646000850 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 680646000851 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 680646000852 Cation efflux family; Region: Cation_efflux; pfam01545 680646000853 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 680646000854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 680646000855 S-adenosylmethionine binding site [chemical binding]; other site 680646000856 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 680646000857 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 680646000858 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 680646000859 active site 680646000860 interdomain interaction site; other site 680646000861 putative metal-binding site [ion binding]; other site 680646000862 nucleotide binding site [chemical binding]; other site 680646000863 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 680646000864 domain I; other site 680646000865 phosphate binding site [ion binding]; other site 680646000866 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 680646000867 domain II; other site 680646000868 domain III; other site 680646000869 nucleotide binding site [chemical binding]; other site 680646000870 DNA binding groove [nucleotide binding] 680646000871 catalytic site [active] 680646000872 domain IV; other site 680646000873 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 680646000874 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 680646000875 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 680646000876 exopolyphosphatase; Region: exo_poly_only; TIGR03706 680646000877 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 680646000878 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 680646000879 Cl- selectivity filter; other site 680646000880 Cl- binding residues [ion binding]; other site 680646000881 pore gating glutamate residue; other site 680646000882 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 680646000883 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 680646000884 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 680646000885 TrkA-N domain; Region: TrkA_N; pfam02254 680646000886 TrkA-C domain; Region: TrkA_C; pfam02080 680646000887 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 680646000888 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 680646000889 potential protein location (hypothetical protein) that overlaps protein (predicted transcriptional regulator) 680646000890 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 680646000891 dimerization interface [polypeptide binding]; other site 680646000892 putative DNA binding site [nucleotide binding]; other site 680646000893 putative Zn2+ binding site [ion binding]; other site 680646000894 Transcriptional regulators [Transcription]; Region: FadR; COG2186 680646000895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 680646000896 DNA-binding site [nucleotide binding]; DNA binding site 680646000897 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 680646000898 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 680646000899 catalytic core [active] 680646000900 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 680646000901 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 680646000902 UbiA prenyltransferase family; Region: UbiA; pfam01040 680646000903 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 680646000904 acyl-activating enzyme (AAE) consensus motif; other site 680646000905 AMP binding site [chemical binding]; other site 680646000906 active site 680646000907 CoA binding site [chemical binding]; other site 680646000908 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 680646000909 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 680646000910 substrate binding site [chemical binding]; other site 680646000911 oxyanion hole (OAH) forming residues; other site 680646000912 trimer interface [polypeptide binding]; other site 680646000913 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 680646000914 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 680646000915 Na binding site [ion binding]; other site 680646000916 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 680646000917 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 680646000918 active site 680646000919 HIGH motif; other site 680646000920 nucleotide binding site [chemical binding]; other site 680646000921 active site 680646000922 KMSKS motif; other site 680646000923 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 680646000924 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 680646000925 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 680646000926 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 680646000927 dimer interface [polypeptide binding]; other site 680646000928 tetramer interface [polypeptide binding]; other site 680646000929 PYR/PP interface [polypeptide binding]; other site 680646000930 TPP binding site [chemical binding]; other site 680646000931 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 680646000932 TPP-binding site [chemical binding]; other site 680646000933 O-succinylbenzoate synthase; Provisional; Region: PRK02901 680646000934 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 680646000935 active site 680646000936 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 680646000937 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 680646000938 active site 680646000939 Cupin domain; Region: Cupin_2; cl17218 680646000940 short chain dehydrogenase; Validated; Region: PRK06182 680646000941 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 680646000942 NADP binding site [chemical binding]; other site 680646000943 active site 680646000944 steroid binding site; other site 680646000945 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 680646000946 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 680646000947 Walker A/P-loop; other site 680646000948 ATP binding site [chemical binding]; other site 680646000949 Q-loop/lid; other site 680646000950 ABC transporter signature motif; other site 680646000951 Walker B; other site 680646000952 D-loop; other site 680646000953 H-loop/switch region; other site 680646000954 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 680646000955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 680646000956 dimer interface [polypeptide binding]; other site 680646000957 conserved gate region; other site 680646000958 putative PBP binding loops; other site 680646000959 ABC-ATPase subunit interface; other site 680646000960 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 680646000961 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 680646000962 substrate binding pocket [chemical binding]; other site 680646000963 membrane-bound complex binding site; other site 680646000964 hinge residues; other site 680646000965 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 680646000966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 680646000967 S-adenosylmethionine binding site [chemical binding]; other site 680646000968 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 680646000969 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 680646000970 substrate binding pocket [chemical binding]; other site 680646000971 chain length determination region; other site 680646000972 substrate-Mg2+ binding site; other site 680646000973 catalytic residues [active] 680646000974 aspartate-rich region 1; other site 680646000975 active site lid residues [active] 680646000976 aspartate-rich region 2; other site 680646000977 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 680646000978 Na2 binding site [ion binding]; other site 680646000979 putative substrate binding site 1 [chemical binding]; other site 680646000980 Na binding site 1 [ion binding]; other site 680646000981 putative substrate binding site 2 [chemical binding]; other site 680646000982 Predicted permeases [General function prediction only]; Region: RarD; COG2962 680646000983 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 680646000984 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 680646000985 metal binding site 2 [ion binding]; metal-binding site 680646000986 putative DNA binding helix; other site 680646000987 metal binding site 1 [ion binding]; metal-binding site 680646000988 dimer interface [polypeptide binding]; other site 680646000989 structural Zn2+ binding site [ion binding]; other site 680646000990 potential protein location (hypothetical protein) that overlaps protein (predicted hydrolase of the HD superfamily) 680646000991 heat shock protein HtpX; Provisional; Region: PRK03072 680646000992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 680646000993 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 680646000994 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 680646000995 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 680646000996 catalytic residues [active] 680646000997 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 680646000998 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 680646000999 helix-hairpin-helix signature motif; other site 680646001000 active site 680646001001 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 680646001002 Predicted membrane protein [Function unknown]; Region: COG3463 680646001003 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 680646001004 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 680646001005 ATP binding site [chemical binding]; other site 680646001006 Mg++ binding site [ion binding]; other site 680646001007 motif III; other site 680646001008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 680646001009 nucleotide binding region [chemical binding]; other site 680646001010 ATP-binding site [chemical binding]; other site 680646001011 DbpA RNA binding domain; Region: DbpA; pfam03880 680646001012 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 680646001013 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 680646001014 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 680646001015 active site 680646001016 catalytic site [active] 680646001017 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 680646001018 active site 680646001019 catalytic site [active] 680646001020 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 680646001021 FAD binding domain; Region: FAD_binding_4; pfam01565 680646001022 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 680646001023 benzoate transport; Region: 2A0115; TIGR00895 680646001024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646001025 putative substrate translocation pore; other site 680646001026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646001027 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 680646001028 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 680646001029 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 680646001030 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 680646001031 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 680646001032 folate binding site [chemical binding]; other site 680646001033 NADP+ binding site [chemical binding]; other site 680646001034 thymidylate synthase; Reviewed; Region: thyA; PRK01827 680646001035 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 680646001036 dimerization interface [polypeptide binding]; other site 680646001037 active site 680646001038 potential protein location (hypothetical protein) that overlaps protein (NTP pyrophosphohydrolase including oxidative damage repair enzyme) 680646001039 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 680646001040 active site 680646001041 Ap6A binding site [chemical binding]; other site 680646001042 nudix motif; other site 680646001043 metal binding site [ion binding]; metal-binding site 680646001044 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 680646001045 catalytic core [active] 680646001046 polyphosphate kinase; Provisional; Region: PRK05443 680646001047 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 680646001048 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 680646001049 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 680646001050 putative domain interface [polypeptide binding]; other site 680646001051 putative active site [active] 680646001052 catalytic site [active] 680646001053 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 680646001054 putative domain interface [polypeptide binding]; other site 680646001055 putative active site [active] 680646001056 catalytic site [active] 680646001057 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 680646001058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 680646001059 Coenzyme A binding pocket [chemical binding]; other site 680646001060 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 680646001061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 680646001062 DNA binding site [nucleotide binding] 680646001063 potential protein location (hypothetical protein) that overlaps protein (response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain) 680646001064 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 680646001065 heme-binding site [chemical binding]; other site 680646001066 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 680646001067 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 680646001068 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 680646001069 potential protein location (hypothetical protein) that overlaps protein (6-phosphofructokinase) 680646001070 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 680646001071 phosphofructokinase; Region: PFK_mixed; TIGR02483 680646001072 active site 680646001073 ADP/pyrophosphate binding site [chemical binding]; other site 680646001074 dimerization interface [polypeptide binding]; other site 680646001075 allosteric effector site; other site 680646001076 fructose-1,6-bisphosphate binding site; other site 680646001077 aspartate aminotransferase; Provisional; Region: PRK05764 680646001078 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 680646001079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646001080 homodimer interface [polypeptide binding]; other site 680646001081 catalytic residue [active] 680646001082 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 680646001083 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 680646001084 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 680646001085 putative homodimer interface [polypeptide binding]; other site 680646001086 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 680646001087 heterodimer interface [polypeptide binding]; other site 680646001088 homodimer interface [polypeptide binding]; other site 680646001089 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 680646001090 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 680646001091 23S rRNA interface [nucleotide binding]; other site 680646001092 L7/L12 interface [polypeptide binding]; other site 680646001093 putative thiostrepton binding site; other site 680646001094 L25 interface [polypeptide binding]; other site 680646001095 potential protein location (hypothetical protein) that overlaps protein (ribosomal protein L1) 680646001096 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 680646001097 mRNA/rRNA interface [nucleotide binding]; other site 680646001098 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 680646001099 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 680646001100 gating phenylalanine in ion channel; other site 680646001101 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 680646001102 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 680646001103 Walker A/P-loop; other site 680646001104 ATP binding site [chemical binding]; other site 680646001105 Q-loop/lid; other site 680646001106 ABC transporter signature motif; other site 680646001107 Walker B; other site 680646001108 D-loop; other site 680646001109 H-loop/switch region; other site 680646001110 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 680646001111 23S rRNA interface [nucleotide binding]; other site 680646001112 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 680646001113 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 680646001114 core dimer interface [polypeptide binding]; other site 680646001115 peripheral dimer interface [polypeptide binding]; other site 680646001116 L10 interface [polypeptide binding]; other site 680646001117 L11 interface [polypeptide binding]; other site 680646001118 putative EF-Tu interaction site [polypeptide binding]; other site 680646001119 putative EF-G interaction site [polypeptide binding]; other site 680646001120 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 680646001121 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 680646001122 substrate binding [chemical binding]; other site 680646001123 active site 680646001124 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 680646001125 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 680646001126 active site turn [active] 680646001127 phosphorylation site [posttranslational modification] 680646001128 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 680646001129 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 680646001130 HPr interaction site; other site 680646001131 glycerol kinase (GK) interaction site [polypeptide binding]; other site 680646001132 active site 680646001133 phosphorylation site [posttranslational modification] 680646001134 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 680646001135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 680646001136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 680646001137 Coenzyme A binding pocket [chemical binding]; other site 680646001138 Transcriptional regulators [Transcription]; Region: PurR; COG1609 680646001139 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 680646001140 DNA binding site [nucleotide binding] 680646001141 domain linker motif; other site 680646001142 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 680646001143 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 680646001144 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 680646001145 dimer interface [polypeptide binding]; other site 680646001146 putative functional site; other site 680646001147 putative MPT binding site; other site 680646001148 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 680646001149 GTP binding site; other site 680646001150 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 680646001151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 680646001152 FeS/SAM binding site; other site 680646001153 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 680646001154 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 680646001155 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 680646001156 substrate binding pocket [chemical binding]; other site 680646001157 membrane-bound complex binding site; other site 680646001158 hinge residues; other site 680646001159 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 680646001160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 680646001161 dimer interface [polypeptide binding]; other site 680646001162 conserved gate region; other site 680646001163 putative PBP binding loops; other site 680646001164 ABC-ATPase subunit interface; other site 680646001165 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 680646001166 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 680646001167 dimer interface [polypeptide binding]; other site 680646001168 putative functional site; other site 680646001169 putative MPT binding site; other site 680646001170 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 680646001171 trimer interface [polypeptide binding]; other site 680646001172 dimer interface [polypeptide binding]; other site 680646001173 putative active site [active] 680646001174 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 680646001175 MPT binding site; other site 680646001176 trimer interface [polypeptide binding]; other site 680646001177 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 680646001178 MoaE homodimer interface [polypeptide binding]; other site 680646001179 MoaD interaction [polypeptide binding]; other site 680646001180 active site residues [active] 680646001181 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 680646001182 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 680646001183 ATP binding site [chemical binding]; other site 680646001184 substrate interface [chemical binding]; other site 680646001185 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 680646001186 active site residue [active] 680646001187 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 680646001188 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 680646001189 [4Fe-4S] binding site [ion binding]; other site 680646001190 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 680646001191 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 680646001192 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 680646001193 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 680646001194 molybdopterin cofactor binding site; other site 680646001195 potential protein location (hypothetical protein) that overlaps protein (nitrate reductase delta subunit) 680646001196 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 680646001197 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 680646001198 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 680646001199 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 680646001200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646001201 putative substrate translocation pore; other site 680646001202 glycine dehydrogenase; Provisional; Region: PRK05367 680646001203 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 680646001204 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 680646001205 catalytic residue [active] 680646001206 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 680646001207 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 680646001208 catalytic residue [active] 680646001209 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 680646001210 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 680646001211 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 680646001212 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 680646001213 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 680646001214 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 680646001215 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 680646001216 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 680646001217 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 680646001218 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 680646001219 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 680646001220 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 680646001221 Peptidase family M23; Region: Peptidase_M23; pfam01551 680646001222 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 680646001223 RPB10 interaction site [polypeptide binding]; other site 680646001224 RPB1 interaction site [polypeptide binding]; other site 680646001225 RPB11 interaction site [polypeptide binding]; other site 680646001226 RPB3 interaction site [polypeptide binding]; other site 680646001227 RPB12 interaction site [polypeptide binding]; other site 680646001228 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 680646001229 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 680646001230 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 680646001231 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 680646001232 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 680646001233 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 680646001234 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 680646001235 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 680646001236 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 680646001237 G-loop; other site 680646001238 DNA binding site [nucleotide binding] 680646001239 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 680646001240 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 680646001241 S17 interaction site [polypeptide binding]; other site 680646001242 S8 interaction site; other site 680646001243 16S rRNA interaction site [nucleotide binding]; other site 680646001244 streptomycin interaction site [chemical binding]; other site 680646001245 23S rRNA interaction site [nucleotide binding]; other site 680646001246 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 680646001247 30S ribosomal protein S7; Validated; Region: PRK05302 680646001248 elongation factor G; Reviewed; Region: PRK00007 680646001249 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 680646001250 G1 box; other site 680646001251 putative GEF interaction site [polypeptide binding]; other site 680646001252 GTP/Mg2+ binding site [chemical binding]; other site 680646001253 Switch I region; other site 680646001254 G2 box; other site 680646001255 G3 box; other site 680646001256 Switch II region; other site 680646001257 G4 box; other site 680646001258 G5 box; other site 680646001259 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 680646001260 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 680646001261 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 680646001262 elongation factor Tu; Reviewed; Region: PRK00049 680646001263 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 680646001264 G1 box; other site 680646001265 GEF interaction site [polypeptide binding]; other site 680646001266 GTP/Mg2+ binding site [chemical binding]; other site 680646001267 Switch I region; other site 680646001268 G2 box; other site 680646001269 G3 box; other site 680646001270 Switch II region; other site 680646001271 G4 box; other site 680646001272 G5 box; other site 680646001273 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 680646001274 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 680646001275 Antibiotic Binding Site [chemical binding]; other site 680646001276 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 680646001277 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 680646001278 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 680646001279 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 680646001280 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 680646001281 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 680646001282 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 680646001283 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 680646001284 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 680646001285 putative translocon binding site; other site 680646001286 protein-rRNA interface [nucleotide binding]; other site 680646001287 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 680646001288 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 680646001289 G-X-X-G motif; other site 680646001290 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 680646001291 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 680646001292 23S rRNA interface [nucleotide binding]; other site 680646001293 putative antibiotic binding site [chemical binding]; other site 680646001294 L25 interface [polypeptide binding]; other site 680646001295 L27 interface [polypeptide binding]; other site 680646001296 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 680646001297 putative translocon interaction site; other site 680646001298 23S rRNA interface [nucleotide binding]; other site 680646001299 signal recognition particle (SRP54) interaction site; other site 680646001300 L23 interface [polypeptide binding]; other site 680646001301 trigger factor interaction site; other site 680646001302 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 680646001303 Uncharacterized conserved protein [Function unknown]; Region: COG3391 680646001304 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 680646001305 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 680646001306 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 680646001307 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 680646001308 RNA binding site [nucleotide binding]; other site 680646001309 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 680646001310 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 680646001311 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 680646001312 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 680646001313 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 680646001314 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 680646001315 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 680646001316 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 680646001317 5S rRNA interface [nucleotide binding]; other site 680646001318 L27 interface [polypeptide binding]; other site 680646001319 23S rRNA interface [nucleotide binding]; other site 680646001320 L5 interface [polypeptide binding]; other site 680646001321 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 680646001322 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 680646001323 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 680646001324 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 680646001325 23S rRNA binding site [nucleotide binding]; other site 680646001326 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 680646001327 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 680646001328 SecY translocase; Region: SecY; pfam00344 680646001329 adenylate kinase; Reviewed; Region: adk; PRK00279 680646001330 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 680646001331 AMP-binding site [chemical binding]; other site 680646001332 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 680646001333 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 680646001334 active site 680646001335 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 680646001336 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 680646001337 FeS/SAM binding site; other site 680646001338 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 680646001339 rRNA binding site [nucleotide binding]; other site 680646001340 predicted 30S ribosome binding site; other site 680646001341 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 680646001342 30S ribosomal protein S13; Region: bact_S13; TIGR03631 680646001343 30S ribosomal protein S11; Validated; Region: PRK05309 680646001344 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 680646001345 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 680646001346 alphaNTD - beta interaction site [polypeptide binding]; other site 680646001347 alphaNTD homodimer interface [polypeptide binding]; other site 680646001348 alphaNTD - beta' interaction site [polypeptide binding]; other site 680646001349 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 680646001350 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 680646001351 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 680646001352 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 680646001353 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 680646001354 dimerization interface 3.5A [polypeptide binding]; other site 680646001355 active site 680646001356 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 680646001357 23S rRNA interface [nucleotide binding]; other site 680646001358 L3 interface [polypeptide binding]; other site 680646001359 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 680646001360 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 680646001361 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 680646001362 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 680646001363 active site 680646001364 substrate binding site [chemical binding]; other site 680646001365 metal binding site [ion binding]; metal-binding site 680646001366 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 680646001367 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 680646001368 pantothenate kinase; Provisional; Region: PRK05439 680646001369 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 680646001370 ATP-binding site [chemical binding]; other site 680646001371 CoA-binding site [chemical binding]; other site 680646001372 Mg2+-binding site [ion binding]; other site 680646001373 potential protein location (hypothetical protein) that overlaps protein (glucosamine 6-phosphate synthetase) 680646001374 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 680646001375 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 680646001376 glutaminase active site [active] 680646001377 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 680646001378 dimer interface [polypeptide binding]; other site 680646001379 active site 680646001380 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 680646001381 dimer interface [polypeptide binding]; other site 680646001382 active site 680646001383 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 680646001384 putative carbohydrate kinase; Provisional; Region: PRK10565 680646001385 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 680646001386 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 680646001387 putative substrate binding site [chemical binding]; other site 680646001388 putative ATP binding site [chemical binding]; other site 680646001389 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 680646001390 Bacterial sugar transferase; Region: Bac_transf; pfam02397 680646001391 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 680646001392 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 680646001393 putative ADP-binding pocket [chemical binding]; other site 680646001394 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 680646001395 alanine racemase; Reviewed; Region: alr; PRK00053 680646001396 active site 680646001397 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 680646001398 dimer interface [polypeptide binding]; other site 680646001399 substrate binding site [chemical binding]; other site 680646001400 catalytic residues [active] 680646001401 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 680646001402 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 680646001403 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 680646001404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 680646001405 Coenzyme A binding pocket [chemical binding]; other site 680646001406 UGMP family protein; Validated; Region: PRK09604 680646001407 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 680646001408 carboxylate-amine ligase; Provisional; Region: PRK13517 680646001409 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 680646001410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 680646001411 S-adenosylmethionine binding site [chemical binding]; other site 680646001412 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 680646001413 oligomerisation interface [polypeptide binding]; other site 680646001414 mobile loop; other site 680646001415 roof hairpin; other site 680646001416 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 680646001417 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 680646001418 ring oligomerisation interface [polypeptide binding]; other site 680646001419 ATP/Mg binding site [chemical binding]; other site 680646001420 stacking interactions; other site 680646001421 hinge regions; other site 680646001422 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 680646001423 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 680646001424 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 680646001425 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 680646001426 active site 680646001427 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 680646001428 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 680646001429 phosphate binding site [ion binding]; other site 680646001430 GMP synthase; Reviewed; Region: guaA; PRK00074 680646001431 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 680646001432 AMP/PPi binding site [chemical binding]; other site 680646001433 candidate oxyanion hole; other site 680646001434 catalytic triad [active] 680646001435 potential glutamine specificity residues [chemical binding]; other site 680646001436 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 680646001437 ATP Binding subdomain [chemical binding]; other site 680646001438 Ligand Binding sites [chemical binding]; other site 680646001439 Dimerization subdomain; other site 680646001440 Membrane transport protein; Region: Mem_trans; cl09117 680646001441 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 680646001442 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 680646001443 Ca binding site [ion binding]; other site 680646001444 active site 680646001445 catalytic site [active] 680646001446 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 680646001447 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 680646001448 Ca binding site [ion binding]; other site 680646001449 active site 680646001450 catalytic site [active] 680646001451 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 680646001452 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 680646001453 putative catalytic site [active] 680646001454 putative metal binding site [ion binding]; other site 680646001455 putative phosphate binding site [ion binding]; other site 680646001456 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 680646001457 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 680646001458 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 680646001459 active site turn [active] 680646001460 phosphorylation site [posttranslational modification] 680646001461 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 680646001462 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 680646001463 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 680646001464 putative active site [active] 680646001465 Part of AAA domain; Region: AAA_19; pfam13245 680646001466 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 680646001467 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 680646001468 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 680646001469 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 680646001470 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 680646001471 active site 680646001472 tetramer interface; other site 680646001473 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 680646001474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 680646001475 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 680646001476 nudix motif; other site 680646001477 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 680646001478 aminotransferase AlaT; Validated; Region: PRK09265 680646001479 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 680646001480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646001481 homodimer interface [polypeptide binding]; other site 680646001482 catalytic residue [active] 680646001483 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 680646001484 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 680646001485 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 680646001486 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 680646001487 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 680646001488 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 680646001489 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 680646001490 Walker A/P-loop; other site 680646001491 ATP binding site [chemical binding]; other site 680646001492 Q-loop/lid; other site 680646001493 ABC transporter signature motif; other site 680646001494 Walker B; other site 680646001495 D-loop; other site 680646001496 H-loop/switch region; other site 680646001497 ABC-2 type transporter; Region: ABC2_membrane; cl17235 680646001498 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 680646001499 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 680646001500 Histidine kinase; Region: HisKA_3; pfam07730 680646001501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 680646001502 ATP binding site [chemical binding]; other site 680646001503 Mg2+ binding site [ion binding]; other site 680646001504 G-X-G motif; other site 680646001505 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 680646001506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 680646001507 active site 680646001508 phosphorylation site [posttranslational modification] 680646001509 intermolecular recognition site; other site 680646001510 dimerization interface [polypeptide binding]; other site 680646001511 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 680646001512 DNA binding residues [nucleotide binding] 680646001513 dimerization interface [polypeptide binding]; other site 680646001514 GTP-binding protein YchF; Reviewed; Region: PRK09601 680646001515 YchF GTPase; Region: YchF; cd01900 680646001516 G1 box; other site 680646001517 GTP/Mg2+ binding site [chemical binding]; other site 680646001518 Switch I region; other site 680646001519 G2 box; other site 680646001520 Switch II region; other site 680646001521 G3 box; other site 680646001522 G4 box; other site 680646001523 G5 box; other site 680646001524 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 680646001525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646001526 Walker A/P-loop; other site 680646001527 ATP binding site [chemical binding]; other site 680646001528 ABC transporter signature motif; other site 680646001529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646001530 ABC transporter signature motif; other site 680646001531 Walker B; other site 680646001532 D-loop; other site 680646001533 H-loop/switch region; other site 680646001534 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 680646001535 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 680646001536 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 680646001537 PhnA protein; Region: PhnA; pfam03831 680646001538 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 680646001539 Predicted membrane protein [Function unknown]; Region: COG4270 680646001540 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 680646001541 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 680646001542 dimer interface [polypeptide binding]; other site 680646001543 catalytic triad [active] 680646001544 peroxidatic and resolving cysteines [active] 680646001545 AzlC protein; Region: AzlC; cl00570 680646001546 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 680646001547 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 680646001548 OsmC-like protein; Region: OsmC; pfam02566 680646001549 lysine transporter; Provisional; Region: PRK10836 680646001550 ribonuclease E; Reviewed; Region: rne; PRK10811 680646001551 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 680646001552 nudix motif; other site 680646001553 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 680646001554 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 680646001555 putative substrate binding pocket [chemical binding]; other site 680646001556 AC domain interface; other site 680646001557 catalytic triad [active] 680646001558 AB domain interface; other site 680646001559 potential protein location (hypothetical protein) that overlaps protein (glucose-6-phosphate isomerase) 680646001560 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 680646001561 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 680646001562 active site 680646001563 dimer interface [polypeptide binding]; other site 680646001564 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 680646001565 dimer interface [polypeptide binding]; other site 680646001566 active site 680646001567 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 680646001568 putative NADH binding site [chemical binding]; other site 680646001569 putative active site [active] 680646001570 nudix motif; other site 680646001571 putative metal binding site [ion binding]; other site 680646001572 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 680646001573 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 680646001574 G1 box; other site 680646001575 putative GEF interaction site [polypeptide binding]; other site 680646001576 GTP/Mg2+ binding site [chemical binding]; other site 680646001577 Switch I region; other site 680646001578 G2 box; other site 680646001579 G3 box; other site 680646001580 Switch II region; other site 680646001581 G4 box; other site 680646001582 G5 box; other site 680646001583 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 680646001584 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 680646001585 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 680646001586 Ferredoxin [Energy production and conversion]; Region: COG1146 680646001587 4Fe-4S binding domain; Region: Fer4; pfam00037 680646001588 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 680646001589 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 680646001590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646001591 homodimer interface [polypeptide binding]; other site 680646001592 catalytic residue [active] 680646001593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 680646001594 dimer interface [polypeptide binding]; other site 680646001595 conserved gate region; other site 680646001596 putative PBP binding loops; other site 680646001597 ABC-ATPase subunit interface; other site 680646001598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 680646001599 dimer interface [polypeptide binding]; other site 680646001600 conserved gate region; other site 680646001601 putative PBP binding loops; other site 680646001602 ABC-ATPase subunit interface; other site 680646001603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 680646001604 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 680646001605 substrate binding pocket [chemical binding]; other site 680646001606 membrane-bound complex binding site; other site 680646001607 hinge residues; other site 680646001608 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 680646001609 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 680646001610 Walker A/P-loop; other site 680646001611 ATP binding site [chemical binding]; other site 680646001612 Q-loop/lid; other site 680646001613 ABC transporter signature motif; other site 680646001614 Walker B; other site 680646001615 D-loop; other site 680646001616 H-loop/switch region; other site 680646001617 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 680646001618 UDP-glucose 4-epimerase; Region: PLN02240 680646001619 NAD binding site [chemical binding]; other site 680646001620 homodimer interface [polypeptide binding]; other site 680646001621 active site 680646001622 substrate binding site [chemical binding]; other site 680646001623 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 680646001624 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 680646001625 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 680646001626 putative trimer interface [polypeptide binding]; other site 680646001627 putative CoA binding site [chemical binding]; other site 680646001628 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 680646001629 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 680646001630 metal binding site [ion binding]; metal-binding site 680646001631 putative dimer interface [polypeptide binding]; other site 680646001632 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 680646001633 Domain of unknown function DUF59; Region: DUF59; cl00941 680646001634 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 680646001635 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 680646001636 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 680646001637 MgtE intracellular N domain; Region: MgtE_N; smart00924 680646001638 FOG: CBS domain [General function prediction only]; Region: COG0517 680646001639 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 680646001640 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 680646001641 proline aminopeptidase P II; Provisional; Region: PRK10879 680646001642 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 680646001643 active site 680646001644 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 680646001645 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 680646001646 active site 680646001647 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 680646001648 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 680646001649 DNA methylase; Region: N6_N4_Mtase; pfam01555 680646001650 potential protein location (hypothetical protein) that overlaps protein (superfamily II DNA and RNA helicase) 680646001651 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 680646001652 DEAD-like helicases superfamily; Region: DEXDc; smart00487 680646001653 ATP binding site [chemical binding]; other site 680646001654 Mg++ binding site [ion binding]; other site 680646001655 motif III; other site 680646001656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 680646001657 nucleotide binding region [chemical binding]; other site 680646001658 ATP-binding site [chemical binding]; other site 680646001659 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 680646001660 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 680646001661 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 680646001662 NAD(P) binding pocket [chemical binding]; other site 680646001663 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 680646001664 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 680646001665 substrate binding site [chemical binding]; other site 680646001666 active site 680646001667 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 680646001668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 680646001669 Chlorite dismutase; Region: Chlor_dismutase; cl01280 680646001670 ferrochelatase; Reviewed; Region: hemH; PRK00035 680646001671 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 680646001672 C-terminal domain interface [polypeptide binding]; other site 680646001673 active site 680646001674 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 680646001675 active site 680646001676 N-terminal domain interface [polypeptide binding]; other site 680646001677 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 680646001678 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 680646001679 domain interfaces; other site 680646001680 active site 680646001681 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 680646001682 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 680646001683 active site 680646001684 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 680646001685 dimer interface [polypeptide binding]; other site 680646001686 active site 680646001687 Schiff base residues; other site 680646001688 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 680646001689 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 680646001690 inhibitor-cofactor binding pocket; inhibition site 680646001691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646001692 catalytic residue [active] 680646001693 Uncharacterized conserved protein [Function unknown]; Region: COG2966 680646001694 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 680646001695 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 680646001696 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 680646001697 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 680646001698 active site 680646001699 catalytic site [active] 680646001700 substrate binding site [chemical binding]; other site 680646001701 Part of AAA domain; Region: AAA_19; pfam13245 680646001702 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 680646001703 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 680646001704 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 680646001705 Part of AAA domain; Region: AAA_19; pfam13245 680646001706 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 680646001707 Phosphotransferase enzyme family; Region: APH; pfam01636 680646001708 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 680646001709 active site 680646001710 ATP binding site [chemical binding]; other site 680646001711 substrate binding site [chemical binding]; other site 680646001712 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 680646001713 Part of AAA domain; Region: AAA_19; pfam13245 680646001714 Family description; Region: UvrD_C_2; pfam13538 680646001715 Protein of unknown function DUF45; Region: DUF45; cl00636 680646001716 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 680646001717 potential protein location (hypothetical protein) that overlaps protein (predicted secreted protein containing a PDZ domain) 680646001718 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 680646001719 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 680646001720 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 680646001721 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 680646001722 Uncharacterized conserved protein [Function unknown]; Region: COG1615 680646001723 Transposase, Mutator family; Region: Transposase_mut; pfam00872 680646001724 MULE transposase domain; Region: MULE; pfam10551 680646001725 Protoglobin; Region: Protoglobin; pfam11563 680646001726 S-layer homology domain; Region: SLH; pfam00395 680646001727 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 680646001728 Repair protein; Region: Repair_PSII; pfam04536 680646001729 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 680646001730 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 680646001731 protein binding site [polypeptide binding]; other site 680646001732 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 680646001733 putative uracil binding site [chemical binding]; other site 680646001734 putative active site [active] 680646001735 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 680646001736 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 680646001737 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 680646001738 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 680646001739 catalytic residue [active] 680646001740 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 680646001741 chorismate mutase; Provisional; Region: PRK09239 680646001742 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 680646001743 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 680646001744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 680646001745 active site 680646001746 phosphorylation site [posttranslational modification] 680646001747 intermolecular recognition site; other site 680646001748 dimerization interface [polypeptide binding]; other site 680646001749 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 680646001750 DNA binding site [nucleotide binding] 680646001751 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 680646001752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 680646001753 dimerization interface [polypeptide binding]; other site 680646001754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 680646001755 dimer interface [polypeptide binding]; other site 680646001756 phosphorylation site [posttranslational modification] 680646001757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 680646001758 ATP binding site [chemical binding]; other site 680646001759 Mg2+ binding site [ion binding]; other site 680646001760 G-X-G motif; other site 680646001761 lipoprotein LpqB; Provisional; Region: PRK13614 680646001762 Sporulation and spore germination; Region: Germane; pfam10646 680646001763 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 680646001764 30S subunit binding site; other site 680646001765 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 680646001766 DEAD/DEAH box helicase; Region: DEAD; pfam00270 680646001767 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 680646001768 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 680646001769 nucleotide binding region [chemical binding]; other site 680646001770 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 680646001771 Helix-turn-helix domain; Region: HTH_17; pfam12728 680646001772 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 680646001773 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 680646001774 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 680646001775 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 680646001776 PAS fold; Region: PAS_4; pfam08448 680646001777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 680646001778 Histidine kinase; Region: HisKA_2; pfam07568 680646001779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 680646001780 ATP binding site [chemical binding]; other site 680646001781 Mg2+ binding site [ion binding]; other site 680646001782 G-X-G motif; other site 680646001783 Transcription factor WhiB; Region: Whib; pfam02467 680646001784 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 680646001785 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 680646001786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 680646001787 UDP-galactopyranose mutase; Region: GLF; pfam03275 680646001788 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 680646001789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 680646001790 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 680646001791 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 680646001792 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 680646001793 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 680646001794 Walker A/P-loop; other site 680646001795 ATP binding site [chemical binding]; other site 680646001796 Q-loop/lid; other site 680646001797 ABC transporter signature motif; other site 680646001798 Walker B; other site 680646001799 D-loop; other site 680646001800 H-loop/switch region; other site 680646001801 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 680646001802 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 680646001803 Walker A motif; other site 680646001804 hexamer interface [polypeptide binding]; other site 680646001805 ATP binding site [chemical binding]; other site 680646001806 Walker B motif; other site 680646001807 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 680646001808 potential protein location (hypothetical protein) that overlaps protein (Flp pilus assembly protein TadC) 680646001809 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 680646001810 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 680646001811 TadE-like protein; Region: TadE; pfam07811 680646001812 peptide chain release factor 2; Validated; Region: prfB; PRK00578 680646001813 This domain is found in peptide chain release factors; Region: PCRF; smart00937 680646001814 RF-1 domain; Region: RF-1; pfam00472 680646001815 potential protein location (hypothetical protein) that overlaps protein (tmRNA-binding protein) 680646001816 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 680646001817 SmpB-tmRNA interface; other site 680646001818 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646001819 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646001820 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 680646001821 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 680646001822 active site 680646001823 Predicted GTPases [General function prediction only]; Region: COG1162 680646001824 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 680646001825 GTPase/Zn-binding domain interface [polypeptide binding]; other site 680646001826 GTP/Mg2+ binding site [chemical binding]; other site 680646001827 G4 box; other site 680646001828 G5 box; other site 680646001829 G1 box; other site 680646001830 Switch I region; other site 680646001831 G2 box; other site 680646001832 G3 box; other site 680646001833 Switch II region; other site 680646001834 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 680646001835 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 680646001836 hinge; other site 680646001837 active site 680646001838 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 680646001839 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 680646001840 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 680646001841 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 680646001842 DNA binding residues [nucleotide binding] 680646001843 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 680646001844 active site 680646001845 catalytic triad [active] 680646001846 oxyanion hole [active] 680646001847 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 680646001848 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 680646001849 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 680646001850 TPP-binding site [chemical binding]; other site 680646001851 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 680646001852 PYR/PP interface [polypeptide binding]; other site 680646001853 dimer interface [polypeptide binding]; other site 680646001854 TPP binding site [chemical binding]; other site 680646001855 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 680646001856 Domain of unknown function DUF21; Region: DUF21; pfam01595 680646001857 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 680646001858 Transporter associated domain; Region: CorC_HlyC; smart01091 680646001859 Domain of unknown function DUF21; Region: DUF21; pfam01595 680646001860 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 680646001861 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 680646001862 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 680646001863 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 680646001864 intersubunit interface [polypeptide binding]; other site 680646001865 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 680646001866 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 680646001867 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 680646001868 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 680646001869 putative PBP binding regions; other site 680646001870 ABC-ATPase subunit interface; other site 680646001871 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 680646001872 metal binding site 2 [ion binding]; metal-binding site 680646001873 putative DNA binding helix; other site 680646001874 metal binding site 1 [ion binding]; metal-binding site 680646001875 dimer interface [polypeptide binding]; other site 680646001876 structural Zn2+ binding site [ion binding]; other site 680646001877 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 680646001878 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 680646001879 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 680646001880 nucleotide binding site/active site [active] 680646001881 HIT family signature motif; other site 680646001882 catalytic residue [active] 680646001883 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 680646001884 glutamine synthetase, type I; Region: GlnA; TIGR00653 680646001885 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 680646001886 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 680646001887 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 680646001888 WzyE protein; Region: WzyE; cl11643 680646001889 lipoyl synthase; Provisional; Region: PRK05481 680646001890 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 680646001891 FeS/SAM binding site; other site 680646001892 lipoate-protein ligase B; Provisional; Region: PRK14345 680646001893 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 680646001894 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 680646001895 E3 interaction surface; other site 680646001896 lipoyl attachment site [posttranslational modification]; other site 680646001897 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 680646001898 E3 interaction surface; other site 680646001899 lipoyl attachment site [posttranslational modification]; other site 680646001900 e3 binding domain; Region: E3_binding; pfam02817 680646001901 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 680646001902 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 680646001903 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 680646001904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 680646001905 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 680646001906 multifunctional aminopeptidase A; Provisional; Region: PRK00913 680646001907 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 680646001908 interface (dimer of trimers) [polypeptide binding]; other site 680646001909 Substrate-binding/catalytic site; other site 680646001910 Zn-binding sites [ion binding]; other site 680646001911 PAC2 family; Region: PAC2; pfam09754 680646001912 potential protein location (hypothetical protein) that overlaps protein (DNA-directed RNA polymerase, sigma subunit) 680646001913 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 680646001914 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 680646001915 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 680646001916 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 680646001917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 680646001918 DNA binding residues [nucleotide binding] 680646001919 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 680646001920 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 680646001921 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 680646001922 active site 680646001923 metal binding site [ion binding]; metal-binding site 680646001924 DNA binding site [nucleotide binding] 680646001925 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 680646001926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646001927 AAA domain; Region: AAA_23; pfam13476 680646001928 Walker A/P-loop; other site 680646001929 ATP binding site [chemical binding]; other site 680646001930 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 680646001931 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646001932 Walker B; other site 680646001933 D-loop; other site 680646001934 H-loop/switch region; other site 680646001935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646001936 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 680646001937 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 680646001938 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 680646001939 NAD binding site [chemical binding]; other site 680646001940 catalytic Zn binding site [ion binding]; other site 680646001941 substrate binding site [chemical binding]; other site 680646001942 structural Zn binding site [ion binding]; other site 680646001943 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 680646001944 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 680646001945 malate:quinone oxidoreductase; Validated; Region: PRK05257 680646001946 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 680646001947 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 680646001948 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 680646001949 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 680646001950 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 680646001951 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 680646001952 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 680646001953 catalytic triad [active] 680646001954 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 680646001955 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 680646001956 PYR/PP interface [polypeptide binding]; other site 680646001957 dimer interface [polypeptide binding]; other site 680646001958 TPP binding site [chemical binding]; other site 680646001959 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 680646001960 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 680646001961 TPP-binding site [chemical binding]; other site 680646001962 dimer interface [polypeptide binding]; other site 680646001963 potential protein location (hypothetical protein) that overlaps protein (acetolactate synthase, small (regulatory) subunit) 680646001964 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 680646001965 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 680646001966 putative valine binding site [chemical binding]; other site 680646001967 dimer interface [polypeptide binding]; other site 680646001968 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 680646001969 potential protein location (hypothetical protein) that overlaps protein (ketol-acid reductoisomerase) 680646001970 ketol-acid reductoisomerase; Provisional; Region: PRK05479 680646001971 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 680646001972 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 680646001973 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 680646001974 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 680646001975 active site 680646001976 HIGH motif; other site 680646001977 KMSKS motif; other site 680646001978 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 680646001979 tRNA binding surface [nucleotide binding]; other site 680646001980 anticodon binding site; other site 680646001981 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 680646001982 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 680646001983 Walker A/P-loop; other site 680646001984 ATP binding site [chemical binding]; other site 680646001985 Q-loop/lid; other site 680646001986 ABC transporter signature motif; other site 680646001987 Walker B; other site 680646001988 D-loop; other site 680646001989 H-loop/switch region; other site 680646001990 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 680646001991 FtsX-like permease family; Region: FtsX; pfam02687 680646001992 FtsX-like permease family; Region: FtsX; pfam02687 680646001993 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 680646001994 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 680646001995 active site 680646001996 NTP binding site [chemical binding]; other site 680646001997 metal binding triad [ion binding]; metal-binding site 680646001998 antibiotic binding site [chemical binding]; other site 680646001999 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 680646002000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 680646002001 active site 680646002002 phosphorylation site [posttranslational modification] 680646002003 intermolecular recognition site; other site 680646002004 dimerization interface [polypeptide binding]; other site 680646002005 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 680646002006 DNA binding residues [nucleotide binding] 680646002007 dimerization interface [polypeptide binding]; other site 680646002008 Histidine kinase; Region: HisKA_3; pfam07730 680646002009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 680646002010 ATP binding site [chemical binding]; other site 680646002011 Mg2+ binding site [ion binding]; other site 680646002012 G-X-G motif; other site 680646002013 potential protein location (hypothetical protein) that overlaps protein (signal transduction histidine kinase) 680646002014 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646002015 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646002016 potential protein location (hypothetical protein) that overlaps protein (isocitrate/isopropylmalate dehydrogenase) 680646002017 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 680646002018 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 680646002019 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 680646002020 homodimer interface [polypeptide binding]; other site 680646002021 substrate-cofactor binding pocket; other site 680646002022 catalytic residue [active] 680646002023 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 680646002024 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 680646002025 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 680646002026 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 680646002027 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 680646002028 HIGH motif; other site 680646002029 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 680646002030 active site 680646002031 KMSKS motif; other site 680646002032 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 680646002033 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 680646002034 active site 680646002035 catalytic residues [active] 680646002036 metal binding site [ion binding]; metal-binding site 680646002037 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 680646002038 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 680646002039 putative active site [active] 680646002040 substrate binding site [chemical binding]; other site 680646002041 putative cosubstrate binding site; other site 680646002042 catalytic site [active] 680646002043 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 680646002044 substrate binding site [chemical binding]; other site 680646002045 16S rRNA methyltransferase B; Provisional; Region: PRK14902 680646002046 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 680646002047 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 680646002048 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 680646002049 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 680646002050 substrate binding site [chemical binding]; other site 680646002051 hexamer interface [polypeptide binding]; other site 680646002052 metal binding site [ion binding]; metal-binding site 680646002053 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 680646002054 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 680646002055 siderophore binding site; other site 680646002056 potential protein location (hypothetical protein) that overlaps protein (poly(3-hydroxybutyrate) depolymerase) 680646002057 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 680646002058 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 680646002059 ABC-ATPase subunit interface; other site 680646002060 dimer interface [polypeptide binding]; other site 680646002061 putative PBP binding regions; other site 680646002062 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 680646002063 ABC-ATPase subunit interface; other site 680646002064 dimer interface [polypeptide binding]; other site 680646002065 putative PBP binding regions; other site 680646002066 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 680646002067 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 680646002068 Walker A/P-loop; other site 680646002069 ATP binding site [chemical binding]; other site 680646002070 Q-loop/lid; other site 680646002071 ABC transporter signature motif; other site 680646002072 Walker B; other site 680646002073 D-loop; other site 680646002074 H-loop/switch region; other site 680646002075 potential protein location (hypothetical protein) that overlaps protein (enterochelin esterase) 680646002076 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 680646002077 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 680646002078 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 680646002079 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 680646002080 acyl-activating enzyme (AAE) consensus motif; other site 680646002081 active site 680646002082 AMP binding site [chemical binding]; other site 680646002083 substrate binding site [chemical binding]; other site 680646002084 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 680646002085 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 680646002086 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 680646002087 acyl-activating enzyme (AAE) consensus motif; other site 680646002088 AMP binding site [chemical binding]; other site 680646002089 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 680646002090 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 680646002091 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 680646002092 dimer interface [polypeptide binding]; other site 680646002093 TPP-binding site [chemical binding]; other site 680646002094 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 680646002095 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 680646002096 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 680646002097 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 680646002098 serine O-acetyltransferase; Region: cysE; TIGR01172 680646002099 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 680646002100 trimer interface [polypeptide binding]; other site 680646002101 active site 680646002102 substrate binding site [chemical binding]; other site 680646002103 CoA binding site [chemical binding]; other site 680646002104 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 680646002105 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 680646002106 dimer interface [polypeptide binding]; other site 680646002107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646002108 catalytic residue [active] 680646002109 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 680646002110 G1 box; other site 680646002111 GTP/Mg2+ binding site [chemical binding]; other site 680646002112 G2 box; other site 680646002113 Switch I region; other site 680646002114 G3 box; other site 680646002115 Switch II region; other site 680646002116 G4 box; other site 680646002117 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 680646002118 G1 box; other site 680646002119 GTP/Mg2+ binding site [chemical binding]; other site 680646002120 G2 box; other site 680646002121 Switch I region; other site 680646002122 G3 box; other site 680646002123 Switch II region; other site 680646002124 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 680646002125 G3 box; other site 680646002126 Switch II region; other site 680646002127 GTP/Mg2+ binding site [chemical binding]; other site 680646002128 G4 box; other site 680646002129 G5 box; other site 680646002130 Bacterial transcriptional regulator; Region: IclR; pfam01614 680646002131 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 680646002132 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 680646002133 substrate binding site [chemical binding]; other site 680646002134 ligand binding site [chemical binding]; other site 680646002135 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 680646002136 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 680646002137 substrate binding site [chemical binding]; other site 680646002138 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 680646002139 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 680646002140 hinge; other site 680646002141 active site 680646002142 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 680646002143 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 680646002144 putative acyl-acceptor binding pocket; other site 680646002145 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 680646002146 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 680646002147 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 680646002148 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 680646002149 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 680646002150 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 680646002151 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 680646002152 ATP binding site [chemical binding]; other site 680646002153 dimerization interface [polypeptide binding]; other site 680646002154 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 680646002155 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 680646002156 ssDNA binding site; other site 680646002157 generic binding surface II; other site 680646002158 DEAD-like helicases superfamily; Region: DEXDc; smart00487 680646002159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 680646002160 ATP binding site [chemical binding]; other site 680646002161 putative Mg++ binding site [ion binding]; other site 680646002162 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 680646002163 nucleotide binding region [chemical binding]; other site 680646002164 ATP-binding site [chemical binding]; other site 680646002165 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 680646002166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 680646002167 S-adenosylmethionine binding site [chemical binding]; other site 680646002168 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 680646002169 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 680646002170 active site 680646002171 (T/H)XGH motif; other site 680646002172 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 680646002173 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 680646002174 ribonuclease III; Reviewed; Region: rnc; PRK00102 680646002175 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 680646002176 dimerization interface [polypeptide binding]; other site 680646002177 active site 680646002178 metal binding site [ion binding]; metal-binding site 680646002179 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 680646002180 dsRNA binding site [nucleotide binding]; other site 680646002181 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 680646002182 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 680646002183 DNA binding site [nucleotide binding] 680646002184 catalytic residue [active] 680646002185 H2TH interface [polypeptide binding]; other site 680646002186 putative catalytic residues [active] 680646002187 turnover-facilitating residue; other site 680646002188 intercalation triad [nucleotide binding]; other site 680646002189 8OG recognition residue [nucleotide binding]; other site 680646002190 putative reading head residues; other site 680646002191 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 680646002192 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 680646002193 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 680646002194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 680646002195 NAD(P) binding site [chemical binding]; other site 680646002196 active site 680646002197 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 680646002198 peptide synthase; Provisional; Region: PRK09274 680646002199 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 680646002200 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 680646002201 acyl-activating enzyme (AAE) consensus motif; other site 680646002202 AMP binding site [chemical binding]; other site 680646002203 active site 680646002204 CoA binding site [chemical binding]; other site 680646002205 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 680646002206 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 680646002207 active site 680646002208 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 680646002209 AAA domain; Region: AAA_23; pfam13476 680646002210 Walker A/P-loop; other site 680646002211 ATP binding site [chemical binding]; other site 680646002212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646002213 ABC transporter signature motif; other site 680646002214 Walker B; other site 680646002215 D-loop; other site 680646002216 H-loop/switch region; other site 680646002217 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 680646002218 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 680646002219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646002220 catalytic residue [active] 680646002221 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 680646002222 substrate binding site [chemical binding]; other site 680646002223 active site 680646002224 catalytic residues [active] 680646002225 heterodimer interface [polypeptide binding]; other site 680646002226 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 680646002227 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 680646002228 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 680646002229 NAD binding site [chemical binding]; other site 680646002230 substrate binding site [chemical binding]; other site 680646002231 catalytic Zn binding site [ion binding]; other site 680646002232 tetramer interface [polypeptide binding]; other site 680646002233 structural Zn binding site [ion binding]; other site 680646002234 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 680646002235 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 680646002236 active site 680646002237 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 680646002238 potential protein location (hypothetical protein) that overlaps protein (pyruvate kinase) 680646002239 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 680646002240 pyruvate kinase; Provisional; Region: PRK06247 680646002241 domain interfaces; other site 680646002242 active site 680646002243 signal recognition particle protein; Provisional; Region: PRK10867 680646002244 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 680646002245 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 680646002246 P loop; other site 680646002247 GTP binding site [chemical binding]; other site 680646002248 Signal peptide binding domain; Region: SRP_SPB; pfam02978 680646002249 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 680646002250 nudix motif; other site 680646002251 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 680646002252 hypothetical protein; Provisional; Region: PRK02821 680646002253 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 680646002254 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 680646002255 RimM N-terminal domain; Region: RimM; pfam01782 680646002256 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 680646002257 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 680646002258 Protein of unknown function (DUF419); Region: DUF419; cl15265 680646002259 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 680646002260 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 680646002261 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 680646002262 ABC transporter; Region: ABC_tran_2; pfam12848 680646002263 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 680646002264 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 680646002265 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 680646002266 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 680646002267 active site 680646002268 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 680646002269 catalytic triad [active] 680646002270 dimer interface [polypeptide binding]; other site 680646002271 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 680646002272 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 680646002273 active site 680646002274 catalytic triad [active] 680646002275 oxyanion hole [active] 680646002276 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 680646002277 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 680646002278 Zn binding site [ion binding]; other site 680646002279 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 680646002280 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 680646002281 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 680646002282 putative DNA binding site [nucleotide binding]; other site 680646002283 catalytic residue [active] 680646002284 putative H2TH interface [polypeptide binding]; other site 680646002285 putative catalytic residues [active] 680646002286 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 680646002287 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 680646002288 potential protein location (hypothetical protein) that overlaps protein (FKBP-type peptidyl-prolyl cis-trans isomerase) 680646002289 trigger factor; Provisional; Region: tig; PRK01490 680646002290 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 680646002291 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 680646002292 Clp protease; Region: CLP_protease; pfam00574 680646002293 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 680646002294 oligomer interface [polypeptide binding]; other site 680646002295 active site residues [active] 680646002296 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 680646002297 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 680646002298 oligomer interface [polypeptide binding]; other site 680646002299 active site residues [active] 680646002300 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 680646002301 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 680646002302 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 680646002303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 680646002304 Walker A motif; other site 680646002305 ATP binding site [chemical binding]; other site 680646002306 Walker B motif; other site 680646002307 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 680646002308 potential protein location (hypothetical protein) that overlaps protein (2-hydroxychromene-2-carboxylate isomerase) 680646002309 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 680646002310 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 680646002311 LssY C-terminus; Region: LssY_C; pfam14067 680646002312 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 680646002313 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 680646002314 active site 680646002315 HIGH motif; other site 680646002316 nucleotide binding site [chemical binding]; other site 680646002317 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 680646002318 active site 680646002319 KMSKS motif; other site 680646002320 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 680646002321 tRNA binding surface [nucleotide binding]; other site 680646002322 anticodon binding site; other site 680646002323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 680646002324 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 680646002325 NAD(P) binding site [chemical binding]; other site 680646002326 active site 680646002327 Htaa; Region: HtaA; pfam04213 680646002328 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 680646002329 putative active site [active] 680646002330 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 680646002331 active site 680646002332 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 680646002333 nitrite reductase subunit NirD; Provisional; Region: PRK14989 680646002334 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 680646002335 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 680646002336 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 680646002337 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 680646002338 active site 680646002339 SAM binding site [chemical binding]; other site 680646002340 homodimer interface [polypeptide binding]; other site 680646002341 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 680646002342 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 680646002343 HIGH motif; other site 680646002344 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 680646002345 active site 680646002346 KMSKS motif; other site 680646002347 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 680646002348 tRNA binding surface [nucleotide binding]; other site 680646002349 anticodon binding site; other site 680646002350 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 680646002351 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 680646002352 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 680646002353 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 680646002354 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 680646002355 putative active site [active] 680646002356 redox center [active] 680646002357 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 680646002358 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 680646002359 homodimer interface [polypeptide binding]; other site 680646002360 oligonucleotide binding site [chemical binding]; other site 680646002361 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 680646002362 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 680646002363 potential protein location (hypothetical protein) that overlaps protein (predicted GTPase) 680646002364 GTPase CgtA; Reviewed; Region: obgE; PRK12296 680646002365 GTP1/OBG; Region: GTP1_OBG; pfam01018 680646002366 Obg GTPase; Region: Obg; cd01898 680646002367 G1 box; other site 680646002368 GTP/Mg2+ binding site [chemical binding]; other site 680646002369 Switch I region; other site 680646002370 G2 box; other site 680646002371 G3 box; other site 680646002372 Switch II region; other site 680646002373 G4 box; other site 680646002374 G5 box; other site 680646002375 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 680646002376 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 680646002377 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 680646002378 active site 680646002379 (T/H)XGH motif; other site 680646002380 Oligomerisation domain; Region: Oligomerisation; pfam02410 680646002381 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 680646002382 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 680646002383 glutaminase; Provisional; Region: PRK00971 680646002384 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 680646002385 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 680646002386 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 680646002387 NodB motif; other site 680646002388 active site 680646002389 catalytic site [active] 680646002390 metal binding site [ion binding]; metal-binding site 680646002391 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646002392 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646002393 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 680646002394 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 680646002395 catalytic residues [active] 680646002396 Uncharacterized conserved protein [Function unknown]; Region: COG3743 680646002397 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 680646002398 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 680646002399 NodB motif; other site 680646002400 active site 680646002401 catalytic site [active] 680646002402 metal binding site [ion binding]; metal-binding site 680646002403 Uncharacterized conserved protein [Function unknown]; Region: COG4850 680646002404 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 680646002405 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 680646002406 catalytic residues [active] 680646002407 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 680646002408 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 680646002409 Class I ribonucleotide reductase; Region: RNR_I; cd01679 680646002410 active site 680646002411 dimer interface [polypeptide binding]; other site 680646002412 catalytic residues [active] 680646002413 effector binding site; other site 680646002414 R2 peptide binding site; other site 680646002415 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 680646002416 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 680646002417 dimer interface [polypeptide binding]; other site 680646002418 putative radical transfer pathway; other site 680646002419 diiron center [ion binding]; other site 680646002420 tyrosyl radical; other site 680646002421 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 680646002422 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 680646002423 catalytic Zn binding site [ion binding]; other site 680646002424 NAD(P) binding site [chemical binding]; other site 680646002425 structural Zn binding site [ion binding]; other site 680646002426 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 680646002427 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 680646002428 Potassium binding sites [ion binding]; other site 680646002429 Cesium cation binding sites [ion binding]; other site 680646002430 potential protein location (hypothetical protein) that overlaps protein (Zn-dependent hydrolase including glyoxylase) 680646002431 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 680646002432 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 680646002433 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 680646002434 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 680646002435 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 680646002436 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 680646002437 beta-galactosidase; Region: BGL; TIGR03356 680646002438 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 680646002439 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 680646002440 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 680646002441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 680646002442 dimerization interface [polypeptide binding]; other site 680646002443 putative DNA binding site [nucleotide binding]; other site 680646002444 putative Zn2+ binding site [ion binding]; other site 680646002445 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 680646002446 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 680646002447 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 680646002448 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 680646002449 active site 680646002450 dimer interface [polypeptide binding]; other site 680646002451 motif 1; other site 680646002452 motif 2; other site 680646002453 motif 3; other site 680646002454 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 680646002455 anticodon binding site; other site 680646002456 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 680646002457 FAD binding domain; Region: FAD_binding_4; pfam01565 680646002458 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 680646002459 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 680646002460 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 680646002461 Mrr N-terminal domain; Region: Mrr_N; pfam14338 680646002462 Restriction endonuclease; Region: Mrr_cat; pfam04471 680646002463 Ion channel; Region: Ion_trans_2; pfam07885 680646002464 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 680646002465 nucleotide binding site/active site [active] 680646002466 HIT family signature motif; other site 680646002467 catalytic residue [active] 680646002468 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 680646002469 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 680646002470 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 680646002471 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 680646002472 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 680646002473 catalytic triad [active] 680646002474 hypothetical protein; Validated; Region: PRK00110 680646002475 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 680646002476 active site 680646002477 putative DNA-binding cleft [nucleotide binding]; other site 680646002478 dimer interface [polypeptide binding]; other site 680646002479 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 680646002480 RuvA N terminal domain; Region: RuvA_N; pfam01330 680646002481 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 680646002482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 680646002483 Walker A motif; other site 680646002484 ATP binding site [chemical binding]; other site 680646002485 Walker B motif; other site 680646002486 arginine finger; other site 680646002487 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 680646002488 Preprotein translocase subunit; Region: YajC; pfam02699 680646002489 protein-export membrane protein SecD; Region: secD; TIGR01129 680646002490 Protein export membrane protein; Region: SecD_SecF; cl14618 680646002491 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 680646002492 Protein export membrane protein; Region: SecD_SecF; pfam02355 680646002493 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 680646002494 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 680646002495 Zn2+ binding site [ion binding]; other site 680646002496 Mg2+ binding site [ion binding]; other site 680646002497 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 680646002498 synthetase active site [active] 680646002499 NTP binding site [chemical binding]; other site 680646002500 metal binding site [ion binding]; metal-binding site 680646002501 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 680646002502 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 680646002503 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 680646002504 HsdM N-terminal domain; Region: HsdM_N; pfam12161 680646002505 Methyltransferase domain; Region: Methyltransf_26; pfam13659 680646002506 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 680646002507 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 680646002508 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 680646002509 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 680646002510 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 680646002511 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 680646002512 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 680646002513 ATP binding site [chemical binding]; other site 680646002514 putative Mg++ binding site [ion binding]; other site 680646002515 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 680646002516 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 680646002517 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 680646002518 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 680646002519 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 680646002520 dimer interface [polypeptide binding]; other site 680646002521 motif 1; other site 680646002522 active site 680646002523 motif 2; other site 680646002524 motif 3; other site 680646002525 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 680646002526 anticodon binding site; other site 680646002527 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 680646002528 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 680646002529 putative active site [active] 680646002530 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 680646002531 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 680646002532 dimer interface [polypeptide binding]; other site 680646002533 anticodon binding site; other site 680646002534 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 680646002535 homodimer interface [polypeptide binding]; other site 680646002536 motif 1; other site 680646002537 active site 680646002538 motif 2; other site 680646002539 GAD domain; Region: GAD; pfam02938 680646002540 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 680646002541 active site 680646002542 motif 3; other site 680646002543 AAA domain; Region: AAA_17; pfam13207 680646002544 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 680646002545 putative active site [active] 680646002546 dimerization interface [polypeptide binding]; other site 680646002547 putative tRNAtyr binding site [nucleotide binding]; other site 680646002548 recombination factor protein RarA; Reviewed; Region: PRK13342 680646002549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 680646002550 Walker A motif; other site 680646002551 ATP binding site [chemical binding]; other site 680646002552 Walker B motif; other site 680646002553 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 680646002554 potential protein location (hypothetical protein) that overlaps protein (ribosomal protein S4) 680646002555 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 680646002556 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 680646002557 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 680646002558 RNA binding surface [nucleotide binding]; other site 680646002559 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 680646002560 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 680646002561 motif 1; other site 680646002562 active site 680646002563 motif 2; other site 680646002564 motif 3; other site 680646002565 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 680646002566 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 680646002567 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 680646002568 YceG-like family; Region: YceG; pfam02618 680646002569 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 680646002570 dimerization interface [polypeptide binding]; other site 680646002571 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 680646002572 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 680646002573 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 680646002574 shikimate binding site; other site 680646002575 NAD(P) binding site [chemical binding]; other site 680646002576 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 680646002577 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 680646002578 Tetramer interface [polypeptide binding]; other site 680646002579 active site 680646002580 FMN-binding site [chemical binding]; other site 680646002581 potential protein location (hypothetical protein) that overlaps protein (shikimate kinase) 680646002582 shikimate kinase; Reviewed; Region: aroK; PRK00131 680646002583 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 680646002584 ADP binding site [chemical binding]; other site 680646002585 magnesium binding site [ion binding]; other site 680646002586 putative shikimate binding site; other site 680646002587 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 680646002588 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 680646002589 active site 680646002590 dimer interface [polypeptide binding]; other site 680646002591 metal binding site [ion binding]; metal-binding site 680646002592 elongation factor P; Validated; Region: PRK00529 680646002593 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 680646002594 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 680646002595 RNA binding site [nucleotide binding]; other site 680646002596 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 680646002597 RNA binding site [nucleotide binding]; other site 680646002598 transcription antitermination factor NusB; Region: nusB; TIGR01951 680646002599 putative RNA binding site [nucleotide binding]; other site 680646002600 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 680646002601 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 680646002602 active site 680646002603 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 680646002604 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 680646002605 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 680646002606 potential protein location (hypothetical protein) that overlaps protein (membrane-associated lipoprotein involved in thiamine biosynthesis) 680646002607 dihydroorotase; Validated; Region: pyrC; PRK09357 680646002608 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 680646002609 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 680646002610 active site 680646002611 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 680646002612 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 680646002613 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 680646002614 catalytic site [active] 680646002615 subunit interface [polypeptide binding]; other site 680646002616 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 680646002617 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 680646002618 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 680646002619 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 680646002620 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 680646002621 ATP-grasp domain; Region: ATP-grasp_4; cl17255 680646002622 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 680646002623 IMP binding site; other site 680646002624 dimer interface [polypeptide binding]; other site 680646002625 interdomain contacts; other site 680646002626 partial ornithine binding site; other site 680646002627 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 680646002628 active site 680646002629 dimer interface [polypeptide binding]; other site 680646002630 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 680646002631 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 680646002632 catalytic site [active] 680646002633 G-X2-G-X-G-K; other site 680646002634 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 680646002635 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 680646002636 Flavoprotein; Region: Flavoprotein; pfam02441 680646002637 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 680646002638 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 680646002639 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 680646002640 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 680646002641 phosphate binding site [ion binding]; other site 680646002642 putative substrate binding pocket [chemical binding]; other site 680646002643 dimer interface [polypeptide binding]; other site 680646002644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 680646002645 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 680646002646 Helix-hairpin-helix motif; Region: HHH; pfam00633 680646002647 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 680646002648 Competence protein; Region: Competence; pfam03772 680646002649 hypothetical protein; Validated; Region: PRK05629 680646002650 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 680646002651 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 680646002652 PemK-like protein; Region: PemK; pfam02452 680646002653 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 680646002654 PAC2 family; Region: PAC2; cl00847 680646002655 GTP-binding protein LepA; Provisional; Region: PRK05433 680646002656 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 680646002657 G1 box; other site 680646002658 putative GEF interaction site [polypeptide binding]; other site 680646002659 GTP/Mg2+ binding site [chemical binding]; other site 680646002660 Switch I region; other site 680646002661 G2 box; other site 680646002662 G3 box; other site 680646002663 Switch II region; other site 680646002664 G4 box; other site 680646002665 G5 box; other site 680646002666 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 680646002667 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 680646002668 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 680646002669 coproporphyrinogen III oxidase; Validated; Region: PRK05628 680646002670 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 680646002671 FeS/SAM binding site; other site 680646002672 HemN C-terminal domain; Region: HemN_C; pfam06969 680646002673 Tic20-like protein; Region: Tic20; pfam09685 680646002674 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 680646002675 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 680646002676 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 680646002677 HSP70 interaction site [polypeptide binding]; other site 680646002678 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 680646002679 Zn binding sites [ion binding]; other site 680646002680 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 680646002681 dimer interface [polypeptide binding]; other site 680646002682 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 680646002683 RNA methyltransferase, RsmE family; Region: TIGR00046 680646002684 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 680646002685 PhoH-like protein; Region: PhoH; pfam02562 680646002686 metal-binding heat shock protein; Provisional; Region: PRK00016 680646002687 Domain of unknown function DUF21; Region: DUF21; pfam01595 680646002688 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 680646002689 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 680646002690 Transporter associated domain; Region: CorC_HlyC; smart01091 680646002691 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 680646002692 Dynamin family; Region: Dynamin_N; pfam00350 680646002693 G1 box; other site 680646002694 GTP/Mg2+ binding site [chemical binding]; other site 680646002695 Switch I region; other site 680646002696 G2 box; other site 680646002697 Switch II region; other site 680646002698 G3 box; other site 680646002699 G4 box; other site 680646002700 GTPase Era; Reviewed; Region: era; PRK00089 680646002701 KH domain; Region: KH_2; pfam07650 680646002702 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 680646002703 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 680646002704 2-isopropylmalate synthase; Validated; Region: PRK03739 680646002705 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 680646002706 active site 680646002707 catalytic residues [active] 680646002708 metal binding site [ion binding]; metal-binding site 680646002709 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 680646002710 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 680646002711 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 680646002712 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 680646002713 active site 680646002714 HIGH motif; other site 680646002715 nucleotide binding site [chemical binding]; other site 680646002716 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 680646002717 active site 680646002718 KMSKS motif; other site 680646002719 potential protein location (hypothetical protein) that overlaps protein (tRNA(1-methyladenosine) methyltransferase) 680646002720 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 680646002721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 680646002722 S-adenosylmethionine binding site [chemical binding]; other site 680646002723 proteasome ATPase; Region: pup_AAA; TIGR03689 680646002724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 680646002725 Walker A motif; other site 680646002726 ATP binding site [chemical binding]; other site 680646002727 Walker B motif; other site 680646002728 arginine finger; other site 680646002729 Pup-ligase protein; Region: Pup_ligase; cl15463 680646002730 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646002731 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646002732 Pup-ligase protein; Region: Pup_ligase; cl15463 680646002733 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 680646002734 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 680646002735 Predicted transcriptional regulator [Transcription]; Region: COG2378 680646002736 WYL domain; Region: WYL; pfam13280 680646002737 WYL domain; Region: WYL; pfam13280 680646002738 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 680646002739 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 680646002740 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 680646002741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 680646002742 ATP binding site [chemical binding]; other site 680646002743 putative Mg++ binding site [ion binding]; other site 680646002744 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 680646002745 nucleotide binding region [chemical binding]; other site 680646002746 ATP-binding site [chemical binding]; other site 680646002747 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 680646002748 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 680646002749 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 680646002750 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 680646002751 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 680646002752 Ligand binding site; other site 680646002753 Putative Catalytic site; other site 680646002754 DXD motif; other site 680646002755 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 680646002756 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 680646002757 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 680646002758 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 680646002759 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 680646002760 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 680646002761 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 680646002762 hypothetical protein; Provisional; Region: PRK07907 680646002763 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 680646002764 active site 680646002765 metal binding site [ion binding]; metal-binding site 680646002766 dimer interface [polypeptide binding]; other site 680646002767 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 680646002768 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 680646002769 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 680646002770 quinone interaction residues [chemical binding]; other site 680646002771 active site 680646002772 catalytic residues [active] 680646002773 FMN binding site [chemical binding]; other site 680646002774 substrate binding site [chemical binding]; other site 680646002775 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 680646002776 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 680646002777 catalytic residue [active] 680646002778 putative FPP diphosphate binding site; other site 680646002779 putative FPP binding hydrophobic cleft; other site 680646002780 dimer interface [polypeptide binding]; other site 680646002781 putative IPP diphosphate binding site; other site 680646002782 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 680646002783 Recombination protein O N terminal; Region: RecO_N; pfam11967 680646002784 Recombination protein O C terminal; Region: RecO_C; pfam02565 680646002785 potential protein location (hypothetical protein) that overlaps protein (dehydrogenase) 680646002786 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 680646002787 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 680646002788 NAD binding site [chemical binding]; other site 680646002789 dimer interface [polypeptide binding]; other site 680646002790 substrate binding site [chemical binding]; other site 680646002791 tetramer (dimer of dimers) interface [polypeptide binding]; other site 680646002792 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 680646002793 amidohydrolase; Region: amidohydrolases; TIGR01891 680646002794 metal binding site [ion binding]; metal-binding site 680646002795 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 680646002796 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 680646002797 putative NAD(P) binding site [chemical binding]; other site 680646002798 catalytic Zn binding site [ion binding]; other site 680646002799 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 680646002800 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 680646002801 Zn binding site [ion binding]; other site 680646002802 HIRAN domain; Region: HIRAN; cl07418 680646002803 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 680646002804 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 680646002805 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 680646002806 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 680646002807 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 680646002808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646002809 Walker A/P-loop; other site 680646002810 ATP binding site [chemical binding]; other site 680646002811 Q-loop/lid; other site 680646002812 ABC transporter signature motif; other site 680646002813 Walker B; other site 680646002814 D-loop; other site 680646002815 H-loop/switch region; other site 680646002816 short chain dehydrogenase; Provisional; Region: PRK07806 680646002817 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 680646002818 potential protein location (hypothetical protein) that overlaps protein (dehydrogenase) 680646002819 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 680646002820 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 680646002821 NAD(P) binding site [chemical binding]; other site 680646002822 homotetramer interface [polypeptide binding]; other site 680646002823 homodimer interface [polypeptide binding]; other site 680646002824 active site 680646002825 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 680646002826 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 680646002827 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 680646002828 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 680646002829 ABC transporter; Region: ABC_tran_2; pfam12848 680646002830 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 680646002831 BioY family; Region: BioY; pfam02632 680646002832 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 680646002833 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 680646002834 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 680646002835 Walker A/P-loop; other site 680646002836 ATP binding site [chemical binding]; other site 680646002837 Q-loop/lid; other site 680646002838 ABC transporter signature motif; other site 680646002839 Walker B; other site 680646002840 D-loop; other site 680646002841 H-loop/switch region; other site 680646002842 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 680646002843 HD domain; Region: HD_4; pfam13328 680646002844 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 680646002845 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 680646002846 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 680646002847 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 680646002848 Walker A/P-loop; other site 680646002849 ATP binding site [chemical binding]; other site 680646002850 Q-loop/lid; other site 680646002851 ABC transporter signature motif; other site 680646002852 Walker B; other site 680646002853 D-loop; other site 680646002854 H-loop/switch region; other site 680646002855 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 680646002856 FeS assembly protein SufD; Region: sufD; TIGR01981 680646002857 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 680646002858 FeS assembly protein SufB; Region: sufB; TIGR01980 680646002859 Predicted transcriptional regulator [Transcription]; Region: COG2345 680646002860 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 680646002861 putative DNA binding site [nucleotide binding]; other site 680646002862 putative Zn2+ binding site [ion binding]; other site 680646002863 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 680646002864 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 680646002865 Walker A/P-loop; other site 680646002866 ATP binding site [chemical binding]; other site 680646002867 Q-loop/lid; other site 680646002868 ABC transporter signature motif; other site 680646002869 Walker B; other site 680646002870 D-loop; other site 680646002871 H-loop/switch region; other site 680646002872 ABC-2 type transporter; Region: ABC2_membrane; cl17235 680646002873 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 680646002874 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 680646002875 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 680646002876 TPP-binding site [chemical binding]; other site 680646002877 dimer interface [polypeptide binding]; other site 680646002878 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 680646002879 PYR/PP interface [polypeptide binding]; other site 680646002880 dimer interface [polypeptide binding]; other site 680646002881 TPP binding site [chemical binding]; other site 680646002882 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 680646002883 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 680646002884 putative active site [active] 680646002885 transaldolase; Provisional; Region: PRK03903 680646002886 catalytic residue [active] 680646002887 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 680646002888 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 680646002889 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 680646002890 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 680646002891 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 680646002892 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase; Region: Glucosamine_iso; pfam01182 680646002893 active site 680646002894 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 680646002895 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 680646002896 putative active site [active] 680646002897 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 680646002898 HicB family; Region: HicB; pfam05534 680646002899 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 680646002900 HicB family; Region: HicB; pfam05534 680646002901 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 680646002902 putative metal binding site [ion binding]; other site 680646002903 potential frameshift: common BLAST hit: gi|256390386|ref|YP_003111950.1| zinc finger SWIM domain protein 680646002904 SWIM zinc finger; Region: SWIM; pfam04434 680646002905 triosephosphate isomerase; Provisional; Region: PRK14567 680646002906 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 680646002907 substrate binding site [chemical binding]; other site 680646002908 dimer interface [polypeptide binding]; other site 680646002909 catalytic triad [active] 680646002910 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 680646002911 RHS Repeat; Region: RHS_repeat; pfam05593 680646002912 RHS Repeat; Region: RHS_repeat; pfam05593 680646002913 RHS Repeat; Region: RHS_repeat; cl11982 680646002914 RHS Repeat; Region: RHS_repeat; pfam05593 680646002915 RHS Repeat; Region: RHS_repeat; pfam05593 680646002916 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 680646002917 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 680646002918 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 680646002919 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 680646002920 nucleophilic elbow; other site 680646002921 catalytic triad; other site 680646002922 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 680646002923 Phosphoglycerate kinase; Region: PGK; pfam00162 680646002924 substrate binding site [chemical binding]; other site 680646002925 hinge regions; other site 680646002926 ADP binding site [chemical binding]; other site 680646002927 catalytic site [active] 680646002928 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 680646002929 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 680646002930 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 680646002931 EDD domain protein, DegV family; Region: DegV; TIGR00762 680646002932 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 680646002933 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 680646002934 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 680646002935 HIGH motif; other site 680646002936 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 680646002937 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 680646002938 active site 680646002939 KMSKS motif; other site 680646002940 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 680646002941 tRNA binding surface [nucleotide binding]; other site 680646002942 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 680646002943 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 680646002944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 680646002945 potential protein location (hypothetical protein) that overlaps protein (primosomal protein N' - superfamily II helicase) 680646002946 primosome assembly protein PriA; Provisional; Region: PRK14873 680646002947 S-adenosylmethionine synthetase; Validated; Region: PRK05250 680646002948 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 680646002949 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 680646002950 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 680646002951 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 680646002952 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 680646002953 GIY-YIG motif/motif A; other site 680646002954 active site 680646002955 catalytic site [active] 680646002956 putative DNA binding site [nucleotide binding]; other site 680646002957 metal binding site [ion binding]; metal-binding site 680646002958 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 680646002959 Helix-hairpin-helix motif; Region: HHH; pfam00633 680646002960 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 680646002961 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 680646002962 putative acyl-acceptor binding pocket; other site 680646002963 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 680646002964 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 680646002965 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 680646002966 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 680646002967 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 680646002968 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 680646002969 dimer interface [polypeptide binding]; other site 680646002970 substrate binding site [chemical binding]; other site 680646002971 ATP binding site [chemical binding]; other site 680646002972 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 680646002973 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 680646002974 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 680646002975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646002976 Walker A/P-loop; other site 680646002977 ATP binding site [chemical binding]; other site 680646002978 Q-loop/lid; other site 680646002979 ABC transporter signature motif; other site 680646002980 Walker B; other site 680646002981 D-loop; other site 680646002982 H-loop/switch region; other site 680646002983 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 680646002984 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 680646002985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646002986 ABC transporter signature motif; other site 680646002987 Walker B; other site 680646002988 D-loop; other site 680646002989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 680646002990 ATP binding site [chemical binding]; other site 680646002991 putative Mg++ binding site [ion binding]; other site 680646002992 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 680646002993 nucleotide binding region [chemical binding]; other site 680646002994 ATP-binding site [chemical binding]; other site 680646002995 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 680646002996 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 680646002997 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 680646002998 excinuclease ABC subunit B; Provisional; Region: PRK05298 680646002999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 680646003000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 680646003001 nucleotide binding region [chemical binding]; other site 680646003002 ATP-binding site [chemical binding]; other site 680646003003 Ultra-violet resistance protein B; Region: UvrB; pfam12344 680646003004 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 680646003005 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 680646003006 ABC-ATPase subunit interface; other site 680646003007 dimer interface [polypeptide binding]; other site 680646003008 putative PBP binding regions; other site 680646003009 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 680646003010 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 680646003011 Walker A/P-loop; other site 680646003012 ATP binding site [chemical binding]; other site 680646003013 Q-loop/lid; other site 680646003014 ABC transporter signature motif; other site 680646003015 Walker B; other site 680646003016 D-loop; other site 680646003017 H-loop/switch region; other site 680646003018 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 680646003019 putative ligand binding residues [chemical binding]; other site 680646003020 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 680646003021 Uncharacterized conserved protein [Function unknown]; Region: COG1739 680646003022 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 680646003023 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 680646003024 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 680646003025 CoA-binding site [chemical binding]; other site 680646003026 ATP-binding [chemical binding]; other site 680646003027 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 680646003028 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 680646003029 RNA binding site [nucleotide binding]; other site 680646003030 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 680646003031 RNA binding site [nucleotide binding]; other site 680646003032 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 680646003033 RNA binding site [nucleotide binding]; other site 680646003034 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 680646003035 RNA binding site [nucleotide binding]; other site 680646003036 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 680646003037 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 680646003038 active site 680646003039 metal binding site 1 [ion binding]; metal-binding site 680646003040 putative 5' ssDNA interaction site; other site 680646003041 metal binding site 3; metal-binding site 680646003042 metal binding site 2 [ion binding]; metal-binding site 680646003043 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 680646003044 putative DNA binding site [nucleotide binding]; other site 680646003045 putative metal binding site [ion binding]; other site 680646003046 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 680646003047 active site 680646003048 substrate binding site [chemical binding]; other site 680646003049 catalytic site [active] 680646003050 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 680646003051 active site 680646003052 DNA binding site [nucleotide binding] 680646003053 catalytic site [active] 680646003054 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 680646003055 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 680646003056 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 680646003057 CoenzymeA binding site [chemical binding]; other site 680646003058 subunit interaction site [polypeptide binding]; other site 680646003059 PHB binding site; other site 680646003060 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 680646003061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 680646003062 active site 680646003063 phosphorylation site [posttranslational modification] 680646003064 intermolecular recognition site; other site 680646003065 dimerization interface [polypeptide binding]; other site 680646003066 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 680646003067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646003068 Major Facilitator Superfamily; Region: MFS_1; pfam07690 680646003069 putative substrate translocation pore; other site 680646003070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646003071 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 680646003072 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 680646003073 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 680646003074 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 680646003075 active site 680646003076 ribulose/triose binding site [chemical binding]; other site 680646003077 phosphate binding site [ion binding]; other site 680646003078 substrate (anthranilate) binding pocket [chemical binding]; other site 680646003079 product (indole) binding pocket [chemical binding]; other site 680646003080 anthranilate synthase component I; Provisional; Region: PRK13571 680646003081 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 680646003082 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 680646003083 potential protein location (hypothetical protein) that overlaps protein (riboflavin synthase beta-chain) 680646003084 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 680646003085 homopentamer interface [polypeptide binding]; other site 680646003086 active site 680646003087 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 680646003088 dimerization interface [polypeptide binding]; other site 680646003089 active site 680646003090 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 680646003091 Lumazine binding domain; Region: Lum_binding; pfam00677 680646003092 Lumazine binding domain; Region: Lum_binding; pfam00677 680646003093 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 680646003094 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 680646003095 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 680646003096 catalytic motif [active] 680646003097 Zn binding site [ion binding]; other site 680646003098 RibD C-terminal domain; Region: RibD_C; pfam01872 680646003099 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 680646003100 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 680646003101 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 680646003102 dimer interface [polypeptide binding]; other site 680646003103 active site 680646003104 acyl carrier protein; Provisional; Region: acpP; PRK00982 680646003105 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 680646003106 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 680646003107 dimer interface [polypeptide binding]; other site 680646003108 active site 680646003109 CoA binding pocket [chemical binding]; other site 680646003110 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 680646003111 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 680646003112 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 680646003113 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 680646003114 active site 680646003115 DNA binding site [nucleotide binding] 680646003116 Int/Topo IB signature motif; other site 680646003117 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 680646003118 DNA protecting protein DprA; Region: dprA; TIGR00732 680646003119 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 680646003120 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 680646003121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 680646003122 Walker A motif; other site 680646003123 ATP binding site [chemical binding]; other site 680646003124 Walker B motif; other site 680646003125 arginine finger; other site 680646003126 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 680646003127 hypothetical protein; Reviewed; Region: PRK12497 680646003128 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 680646003129 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 680646003130 RNA/DNA hybrid binding site [nucleotide binding]; other site 680646003131 active site 680646003132 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 680646003133 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 680646003134 Catalytic site [active] 680646003135 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 680646003136 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 680646003137 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 680646003138 dimer interface [polypeptide binding]; other site 680646003139 ssDNA binding site [nucleotide binding]; other site 680646003140 tetramer (dimer of dimers) interface [polypeptide binding]; other site 680646003141 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 680646003142 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 680646003143 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 680646003144 catalytic site [active] 680646003145 putative active site [active] 680646003146 putative substrate binding site [chemical binding]; other site 680646003147 dimer interface [polypeptide binding]; other site 680646003148 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 680646003149 active site 680646003150 catalytic residues [active] 680646003151 metal binding site [ion binding]; metal-binding site 680646003152 hypothetical protein; Validated; Region: PRK02101 680646003153 S-layer homology domain; Region: SLH; pfam00395 680646003154 S-layer homology domain; Region: SLH; pfam00395 680646003155 S-layer homology domain; Region: SLH; pfam00395 680646003156 potential protein location (hypothetical protein) that overlaps protein (predicted nucleic acid-binding protein) 680646003157 S-layer homology domain; Region: SLH; pfam00395 680646003158 S-layer homology domain; Region: SLH; pfam00395 680646003159 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 680646003160 Uncharacterized conserved protein [Function unknown]; Region: COG0327 680646003161 methionine sulfoxide reductase A; Provisional; Region: PRK14054 680646003162 Uncharacterized conserved protein [Function unknown]; Region: COG3391 680646003163 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 680646003164 structural tetrad; other site 680646003165 Uncharacterized conserved protein [Function unknown]; Region: COG3391 680646003166 S-layer homology domain; Region: SLH; pfam00395 680646003167 S-layer homology domain; Region: SLH; pfam00395 680646003168 CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764 680646003169 CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621 680646003170 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 680646003171 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 680646003172 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 680646003173 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 680646003174 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 680646003175 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 680646003176 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 680646003177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 680646003178 Predicted membrane protein [Function unknown]; Region: COG2855 680646003179 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 680646003180 putative deacylase active site [active] 680646003181 SelR domain; Region: SelR; pfam01641 680646003182 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 680646003183 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 680646003184 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 680646003185 catalytic site [active] 680646003186 putative active site [active] 680646003187 putative substrate binding site [chemical binding]; other site 680646003188 HRDC domain; Region: HRDC; pfam00570 680646003189 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 680646003190 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 680646003191 iron-sulfur cluster [ion binding]; other site 680646003192 [2Fe-2S] cluster binding site [ion binding]; other site 680646003193 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 680646003194 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 680646003195 TPP-binding site [chemical binding]; other site 680646003196 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 680646003197 PYR/PP interface [polypeptide binding]; other site 680646003198 dimer interface [polypeptide binding]; other site 680646003199 TPP binding site [chemical binding]; other site 680646003200 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 680646003201 TRAM domain; Region: TRAM; pfam01938 680646003202 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 680646003203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 680646003204 S-adenosylmethionine binding site [chemical binding]; other site 680646003205 Amino acid permease; Region: AA_permease_2; pfam13520 680646003206 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 680646003207 TrkA-N domain; Region: TrkA_N; pfam02254 680646003208 TrkA-C domain; Region: TrkA_C; pfam02080 680646003209 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 680646003210 TrkA-N domain; Region: TrkA_N; pfam02254 680646003211 TrkA-C domain; Region: TrkA_C; pfam02080 680646003212 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 680646003213 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 680646003214 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 680646003215 trimer interface [polypeptide binding]; other site 680646003216 active site 680646003217 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 680646003218 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 680646003219 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 680646003220 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 680646003221 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 680646003222 CAP-like domain; other site 680646003223 active site 680646003224 primary dimer interface [polypeptide binding]; other site 680646003225 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 680646003226 hypothetical protein; Provisional; Region: PRK10621 680646003227 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 680646003228 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 680646003229 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 680646003230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646003231 Walker A/P-loop; other site 680646003232 ATP binding site [chemical binding]; other site 680646003233 Q-loop/lid; other site 680646003234 ABC transporter signature motif; other site 680646003235 Walker B; other site 680646003236 D-loop; other site 680646003237 H-loop/switch region; other site 680646003238 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 680646003239 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 680646003240 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 680646003241 Walker A/P-loop; other site 680646003242 ATP binding site [chemical binding]; other site 680646003243 Q-loop/lid; other site 680646003244 ABC transporter signature motif; other site 680646003245 Walker B; other site 680646003246 D-loop; other site 680646003247 H-loop/switch region; other site 680646003248 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 680646003249 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 680646003250 Walker A/P-loop; other site 680646003251 ATP binding site [chemical binding]; other site 680646003252 Q-loop/lid; other site 680646003253 ABC transporter signature motif; other site 680646003254 Walker B; other site 680646003255 D-loop; other site 680646003256 H-loop/switch region; other site 680646003257 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 680646003258 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 680646003259 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 680646003260 HlyD family secretion protein; Region: HlyD_3; pfam13437 680646003261 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 680646003262 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 680646003263 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 680646003264 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 680646003265 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 680646003266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 680646003267 ATP binding site [chemical binding]; other site 680646003268 Mg2+ binding site [ion binding]; other site 680646003269 G-X-G motif; other site 680646003270 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 680646003271 anchoring element; other site 680646003272 dimer interface [polypeptide binding]; other site 680646003273 ATP binding site [chemical binding]; other site 680646003274 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 680646003275 active site 680646003276 metal binding site [ion binding]; metal-binding site 680646003277 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 680646003278 RDD family; Region: RDD; pfam06271 680646003279 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 680646003280 active site 680646003281 dimerization interface [polypeptide binding]; other site 680646003282 ribonuclease PH; Reviewed; Region: rph; PRK00173 680646003283 Ribonuclease PH; Region: RNase_PH_bact; cd11362 680646003284 hexamer interface [polypeptide binding]; other site 680646003285 active site 680646003286 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 680646003287 glutamate racemase; Provisional; Region: PRK00865 680646003288 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 680646003289 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 680646003290 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 680646003291 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 680646003292 active site 680646003293 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 680646003294 catalytic triad [active] 680646003295 metal binding site [ion binding]; metal-binding site 680646003296 conserved cis-peptide bond; other site 680646003297 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 680646003298 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 680646003299 ATP binding site [chemical binding]; other site 680646003300 putative Mg++ binding site [ion binding]; other site 680646003301 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 680646003302 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 680646003303 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 680646003304 Walker A/P-loop; other site 680646003305 ATP binding site [chemical binding]; other site 680646003306 Q-loop/lid; other site 680646003307 ABC transporter signature motif; other site 680646003308 Walker B; other site 680646003309 D-loop; other site 680646003310 H-loop/switch region; other site 680646003311 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 680646003312 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 680646003313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 680646003314 binding surface 680646003315 TPR motif; other site 680646003316 Domain of unknown function DUF20; Region: UPF0118; pfam01594 680646003317 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 680646003318 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 680646003319 hypothetical protein; Provisional; Region: PRK03298 680646003320 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 680646003321 gamma subunit interface [polypeptide binding]; other site 680646003322 epsilon subunit interface [polypeptide binding]; other site 680646003323 LBP interface [polypeptide binding]; other site 680646003324 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 680646003325 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 680646003326 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 680646003327 alpha subunit interaction interface [polypeptide binding]; other site 680646003328 Walker A motif; other site 680646003329 ATP binding site [chemical binding]; other site 680646003330 Walker B motif; other site 680646003331 inhibitor binding site; inhibition site 680646003332 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 680646003333 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 680646003334 core domain interface [polypeptide binding]; other site 680646003335 delta subunit interface [polypeptide binding]; other site 680646003336 epsilon subunit interface [polypeptide binding]; other site 680646003337 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 680646003338 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 680646003339 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 680646003340 beta subunit interaction interface [polypeptide binding]; other site 680646003341 Walker A motif; other site 680646003342 ATP binding site [chemical binding]; other site 680646003343 Walker B motif; other site 680646003344 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 680646003345 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 680646003346 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 680646003347 potential protein location (hypothetical protein) that overlaps protein (F0F1-type ATP synthase, delta subunit) 680646003348 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 680646003349 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 680646003350 ATP synthase subunit C; Region: ATP-synt_C; cl00466 680646003351 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 680646003352 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 680646003353 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 680646003354 Mg++ binding site [ion binding]; other site 680646003355 putative catalytic motif [active] 680646003356 putative substrate binding site [chemical binding]; other site 680646003357 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 680646003358 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 680646003359 NAD(P) binding site [chemical binding]; other site 680646003360 homodimer interface [polypeptide binding]; other site 680646003361 substrate binding site [chemical binding]; other site 680646003362 active site 680646003363 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 680646003364 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 680646003365 Probable Catalytic site; other site 680646003366 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 680646003367 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 680646003368 active site 680646003369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 680646003370 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 680646003371 NAD(P) binding site [chemical binding]; other site 680646003372 active site 680646003373 potential protein location (hypothetical protein) that overlaps protein (putative translation factor) 680646003374 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 680646003375 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 680646003376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 680646003377 S-adenosylmethionine binding site [chemical binding]; other site 680646003378 peptide chain release factor 1; Validated; Region: prfA; PRK00591 680646003379 This domain is found in peptide chain release factors; Region: PCRF; smart00937 680646003380 RF-1 domain; Region: RF-1; pfam00472 680646003381 potential protein location (hypothetical protein) that overlaps protein (transcription termination factor) 680646003382 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 680646003383 transcription termination factor Rho; Provisional; Region: rho; PRK09376 680646003384 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 680646003385 RNA binding site [nucleotide binding]; other site 680646003386 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 680646003387 multimer interface [polypeptide binding]; other site 680646003388 Walker A motif; other site 680646003389 ATP binding site [chemical binding]; other site 680646003390 Walker B motif; other site 680646003391 homoserine kinase; Provisional; Region: PRK01212 680646003392 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 680646003393 threonine synthase; Reviewed; Region: PRK06721 680646003394 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 680646003395 homodimer interface [polypeptide binding]; other site 680646003396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646003397 catalytic residue [active] 680646003398 homoserine dehydrogenase; Provisional; Region: PRK06349 680646003399 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 680646003400 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 680646003401 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 680646003402 diaminopimelate decarboxylase; Region: lysA; TIGR01048 680646003403 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 680646003404 active site 680646003405 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 680646003406 substrate binding site [chemical binding]; other site 680646003407 catalytic residues [active] 680646003408 dimer interface [polypeptide binding]; other site 680646003409 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 680646003410 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 680646003411 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 680646003412 active site 680646003413 HIGH motif; other site 680646003414 KMSK motif region; other site 680646003415 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 680646003416 tRNA binding surface [nucleotide binding]; other site 680646003417 anticodon binding site; other site 680646003418 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 680646003419 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 680646003420 putative NAD(P) binding site [chemical binding]; other site 680646003421 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 680646003422 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 680646003423 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 680646003424 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 680646003425 DNA binding residues [nucleotide binding] 680646003426 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 680646003427 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 680646003428 ATP binding site [chemical binding]; other site 680646003429 putative Mg++ binding site [ion binding]; other site 680646003430 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 680646003431 nucleotide binding region [chemical binding]; other site 680646003432 ATP-binding site [chemical binding]; other site 680646003433 Helicase associated domain (HA2); Region: HA2; pfam04408 680646003434 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 680646003435 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 680646003436 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 680646003437 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 680646003438 active site 680646003439 potential protein location (hypothetical protein) that overlaps protein (restriction endonuclease) 680646003440 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 680646003441 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 680646003442 metal binding triad; other site 680646003443 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 680646003444 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 680646003445 metal binding triad; other site 680646003446 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 680646003447 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 680646003448 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 680646003449 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 680646003450 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 680646003451 active site 680646003452 oligomerization interface [polypeptide binding]; other site 680646003453 metal binding site [ion binding]; metal-binding site 680646003454 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 680646003455 active site 680646003456 fructokinase; Reviewed; Region: PRK09557 680646003457 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 680646003458 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 680646003459 ATP cone domain; Region: ATP-cone; pfam03477 680646003460 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 680646003461 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 680646003462 active site 680646003463 PHP Thumb interface [polypeptide binding]; other site 680646003464 metal binding site [ion binding]; metal-binding site 680646003465 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 680646003466 generic binding surface II; other site 680646003467 generic binding surface I; other site 680646003468 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 680646003469 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 680646003470 RNA binding surface [nucleotide binding]; other site 680646003471 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 680646003472 active site 680646003473 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 680646003474 DivIVA domain; Region: DivI1A_domain; TIGR03544 680646003475 Protein of unknown function (DUF552); Region: DUF552; pfam04472 680646003476 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 680646003477 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 680646003478 catalytic residue [active] 680646003479 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 680646003480 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 680646003481 potential protein location (hypothetical protein) that overlaps protein (cell division GTPase) 680646003482 cell division protein FtsZ; Validated; Region: PRK09330 680646003483 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 680646003484 nucleotide binding site [chemical binding]; other site 680646003485 SulA interaction site; other site 680646003486 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 680646003487 Cell division protein FtsQ; Region: FtsQ; pfam03799 680646003488 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 680646003489 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 680646003490 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 680646003491 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 680646003492 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 680646003493 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 680646003494 active site 680646003495 homodimer interface [polypeptide binding]; other site 680646003496 cell division protein FtsW; Region: ftsW; TIGR02614 680646003497 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 680646003498 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 680646003499 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 680646003500 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 680646003501 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 680646003502 Mg++ binding site [ion binding]; other site 680646003503 putative catalytic motif [active] 680646003504 putative substrate binding site [chemical binding]; other site 680646003505 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 680646003506 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 680646003507 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 680646003508 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 680646003509 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 680646003510 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 680646003511 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 680646003512 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 680646003513 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 680646003514 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 680646003515 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 680646003516 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 680646003517 MraW methylase family; Region: Methyltransf_5; cl17771 680646003518 cell division protein MraZ; Reviewed; Region: PRK00326 680646003519 MraZ protein; Region: MraZ; pfam02381 680646003520 MraZ protein; Region: MraZ; pfam02381 680646003521 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 680646003522 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 680646003523 active site 680646003524 DNA polymerase IV; Validated; Region: PRK02406 680646003525 DNA binding site [nucleotide binding] 680646003526 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 680646003527 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 680646003528 substrate binding pocket [chemical binding]; other site 680646003529 chain length determination region; other site 680646003530 substrate-Mg2+ binding site; other site 680646003531 catalytic residues [active] 680646003532 aspartate-rich region 1; other site 680646003533 active site lid residues [active] 680646003534 aspartate-rich region 2; other site 680646003535 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 680646003536 Catalytic domain of Protein Kinases; Region: PKc; cd00180 680646003537 active site 680646003538 ATP binding site [chemical binding]; other site 680646003539 substrate binding site [chemical binding]; other site 680646003540 activation loop (A-loop); other site 680646003541 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 680646003542 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 680646003543 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 680646003544 putative acyl-acceptor binding pocket; other site 680646003545 Esterase/lipase [General function prediction only]; Region: COG1647 680646003546 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 680646003547 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 680646003548 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 680646003549 acyl-activating enzyme (AAE) consensus motif; other site 680646003550 putative AMP binding site [chemical binding]; other site 680646003551 putative active site [active] 680646003552 putative CoA binding site [chemical binding]; other site 680646003553 mycothione reductase; Reviewed; Region: PRK07846 680646003554 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 680646003555 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 680646003556 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 680646003557 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 680646003558 P-loop; other site 680646003559 Magnesium ion binding site [ion binding]; other site 680646003560 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 680646003561 Magnesium ion binding site [ion binding]; other site 680646003562 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 680646003563 DNA binding residues [nucleotide binding] 680646003564 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 680646003565 putative dimer interface [polypeptide binding]; other site 680646003566 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 680646003567 DNA binding residues [nucleotide binding] 680646003568 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 680646003569 dimer interface [polypeptide binding]; other site 680646003570 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 680646003571 lipoyl attachment site [posttranslational modification]; other site 680646003572 Proline dehydrogenase; Region: Pro_dh; cl03282 680646003573 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 680646003574 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 680646003575 NAD(P) binding site [chemical binding]; other site 680646003576 catalytic residues [active] 680646003577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 680646003578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 680646003579 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 680646003580 putative dimerization interface [polypeptide binding]; other site 680646003581 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 680646003582 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 680646003583 DNA binding residues [nucleotide binding] 680646003584 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 680646003585 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 680646003586 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 680646003587 amphipathic channel; other site 680646003588 Asn-Pro-Ala signature motifs; other site 680646003589 glycerol kinase; Provisional; Region: glpK; PRK00047 680646003590 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 680646003591 N- and C-terminal domain interface [polypeptide binding]; other site 680646003592 active site 680646003593 MgATP binding site [chemical binding]; other site 680646003594 catalytic site [active] 680646003595 metal binding site [ion binding]; metal-binding site 680646003596 putative homotetramer interface [polypeptide binding]; other site 680646003597 glycerol binding site [chemical binding]; other site 680646003598 homodimer interface [polypeptide binding]; other site 680646003599 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 680646003600 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 680646003601 DNA binding site [nucleotide binding] 680646003602 active site 680646003603 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 680646003604 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 680646003605 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 680646003606 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 680646003607 L-lactate permease; Region: Lactate_perm; cl00701 680646003608 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 680646003609 L-lactate permease; Region: Lactate_perm; cl00701 680646003610 GTP-binding protein Der; Reviewed; Region: PRK03003 680646003611 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 680646003612 G1 box; other site 680646003613 GTP/Mg2+ binding site [chemical binding]; other site 680646003614 Switch I region; other site 680646003615 G2 box; other site 680646003616 Switch II region; other site 680646003617 G3 box; other site 680646003618 G4 box; other site 680646003619 G5 box; other site 680646003620 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 680646003621 G1 box; other site 680646003622 GTP/Mg2+ binding site [chemical binding]; other site 680646003623 Switch I region; other site 680646003624 G2 box; other site 680646003625 G3 box; other site 680646003626 Switch II region; other site 680646003627 G4 box; other site 680646003628 G5 box; other site 680646003629 cytidylate kinase; Provisional; Region: cmk; PRK00023 680646003630 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 680646003631 CMP-binding site; other site 680646003632 The sites determining sugar specificity; other site 680646003633 prephenate dehydrogenase; Validated; Region: PRK06545 680646003634 prephenate dehydrogenase; Validated; Region: PRK08507 680646003635 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 680646003636 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 680646003637 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 680646003638 RNA binding surface [nucleotide binding]; other site 680646003639 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 680646003640 active site 680646003641 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 680646003642 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 680646003643 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 680646003644 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 680646003645 P-loop; other site 680646003646 Magnesium ion binding site [ion binding]; other site 680646003647 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 680646003648 Magnesium ion binding site [ion binding]; other site 680646003649 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 680646003650 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 680646003651 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 680646003652 active site 680646003653 DNA binding site [nucleotide binding] 680646003654 Int/Topo IB signature motif; other site 680646003655 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 680646003656 dimer interface [polypeptide binding]; other site 680646003657 ADP-ribose binding site [chemical binding]; other site 680646003658 active site 680646003659 nudix motif; other site 680646003660 metal binding site [ion binding]; metal-binding site 680646003661 CTP synthetase; Validated; Region: pyrG; PRK05380 680646003662 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 680646003663 Catalytic site [active] 680646003664 active site 680646003665 UTP binding site [chemical binding]; other site 680646003666 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 680646003667 active site 680646003668 putative oxyanion hole; other site 680646003669 catalytic triad [active] 680646003670 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 680646003671 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 680646003672 Walker A/P-loop; other site 680646003673 ATP binding site [chemical binding]; other site 680646003674 Q-loop/lid; other site 680646003675 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 680646003676 ABC transporter signature motif; other site 680646003677 Walker B; other site 680646003678 D-loop; other site 680646003679 H-loop/switch region; other site 680646003680 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 680646003681 ATP-NAD kinase; Region: NAD_kinase; pfam01513 680646003682 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 680646003683 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 680646003684 RNA binding surface [nucleotide binding]; other site 680646003685 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 680646003686 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 680646003687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 680646003688 active site 680646003689 motif I; other site 680646003690 motif II; other site 680646003691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 680646003692 potential protein location (hypothetical protein) that overlaps protein (tyrosyl-tRNA synthetase) 680646003693 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 680646003694 active site 680646003695 KMSKS motif; other site 680646003696 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 680646003697 RNA binding surface [nucleotide binding]; other site 680646003698 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 680646003699 Part of AAA domain; Region: AAA_19; pfam13245 680646003700 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 680646003701 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 680646003702 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 680646003703 acyl-activating enzyme (AAE) consensus motif; other site 680646003704 AMP binding site [chemical binding]; other site 680646003705 active site 680646003706 CoA binding site [chemical binding]; other site 680646003707 arginine repressor; Provisional; Region: PRK03341 680646003708 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 680646003709 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 680646003710 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 680646003711 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 680646003712 putative tRNA-binding site [nucleotide binding]; other site 680646003713 B3/4 domain; Region: B3_4; pfam03483 680646003714 tRNA synthetase B5 domain; Region: B5; smart00874 680646003715 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 680646003716 dimer interface [polypeptide binding]; other site 680646003717 motif 1; other site 680646003718 motif 3; other site 680646003719 motif 2; other site 680646003720 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 680646003721 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 680646003722 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 680646003723 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 680646003724 dimer interface [polypeptide binding]; other site 680646003725 motif 1; other site 680646003726 active site 680646003727 motif 2; other site 680646003728 motif 3; other site 680646003729 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 680646003730 potential protein location (hypothetical protein) that overlaps protein (predicted periplasmic lipoprotein involved in iron transport) 680646003731 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 680646003732 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 680646003733 Imelysin; Region: Peptidase_M75; pfam09375 680646003734 Iron permease FTR1 family; Region: FTR1; pfam03239 680646003735 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 680646003736 active site 680646003737 8-oxo-dGMP binding site [chemical binding]; other site 680646003738 nudix motif; other site 680646003739 metal binding site [ion binding]; metal-binding site 680646003740 Predicted membrane protein [Function unknown]; Region: COG2323 680646003741 Cation efflux family; Region: Cation_efflux; pfam01545 680646003742 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 680646003743 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 680646003744 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 680646003745 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 680646003746 23S rRNA binding site [nucleotide binding]; other site 680646003747 L21 binding site [polypeptide binding]; other site 680646003748 L13 binding site [polypeptide binding]; other site 680646003749 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 680646003750 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 680646003751 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 680646003752 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 680646003753 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 680646003754 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 680646003755 catalytic residues [active] 680646003756 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855 680646003757 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 680646003758 conserved cys residue [active] 680646003759 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 680646003760 LexA repressor; Validated; Region: PRK00215 680646003761 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 680646003762 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 680646003763 Catalytic site [active] 680646003764 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 680646003765 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 680646003766 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 680646003767 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 680646003768 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 680646003769 HflX GTPase family; Region: HflX; cd01878 680646003770 G1 box; other site 680646003771 GTP/Mg2+ binding site [chemical binding]; other site 680646003772 Switch I region; other site 680646003773 G2 box; other site 680646003774 G3 box; other site 680646003775 Switch II region; other site 680646003776 G4 box; other site 680646003777 G5 box; other site 680646003778 Methyltransferase domain; Region: Methyltransf_31; pfam13847 680646003779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 680646003780 S-adenosylmethionine binding site [chemical binding]; other site 680646003781 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 680646003782 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 680646003783 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 680646003784 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 680646003785 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 680646003786 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 680646003787 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 680646003788 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 680646003789 FeS/SAM binding site; other site 680646003790 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 680646003791 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 680646003792 recombinase A; Provisional; Region: recA; PRK09354 680646003793 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 680646003794 hexamer interface [polypeptide binding]; other site 680646003795 Walker A motif; other site 680646003796 ATP binding site [chemical binding]; other site 680646003797 Walker B motif; other site 680646003798 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 680646003799 potential protein location (hypothetical protein) that overlaps protein (predicted transcriptional regulator) 680646003800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 680646003801 non-specific DNA binding site [nucleotide binding]; other site 680646003802 salt bridge; other site 680646003803 sequence-specific DNA binding site [nucleotide binding]; other site 680646003804 Competence-damaged protein; Region: CinA; pfam02464 680646003805 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 680646003806 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 680646003807 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 680646003808 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 680646003809 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 680646003810 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 680646003811 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 680646003812 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 680646003813 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 680646003814 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 680646003815 dimer interface [polypeptide binding]; other site 680646003816 active site 680646003817 catalytic residue [active] 680646003818 dihydrodipicolinate reductase; Provisional; Region: PRK00048 680646003819 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 680646003820 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 680646003821 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 680646003822 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 680646003823 active site 680646003824 catalytic triad [active] 680646003825 oxyanion hole [active] 680646003826 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 680646003827 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 680646003828 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 680646003829 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 680646003830 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 680646003831 oligomer interface [polypeptide binding]; other site 680646003832 RNA binding site [nucleotide binding]; other site 680646003833 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 680646003834 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 680646003835 RNase E interface [polypeptide binding]; other site 680646003836 trimer interface [polypeptide binding]; other site 680646003837 active site 680646003838 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 680646003839 putative nucleic acid binding region [nucleotide binding]; other site 680646003840 G-X-X-G motif; other site 680646003841 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 680646003842 RNA binding site [nucleotide binding]; other site 680646003843 domain interface; other site 680646003844 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 680646003845 16S/18S rRNA binding site [nucleotide binding]; other site 680646003846 S13e-L30e interaction site [polypeptide binding]; other site 680646003847 25S rRNA binding site [nucleotide binding]; other site 680646003848 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 680646003849 Spore germination protein; Region: Spore_permease; cl17796 680646003850 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 680646003851 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 680646003852 S-ribosylhomocysteinase; Provisional; Region: PRK02260 680646003853 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 680646003854 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 680646003855 active site 680646003856 Riboflavin kinase; Region: Flavokinase; smart00904 680646003857 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 680646003858 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 680646003859 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 680646003860 RNA binding site [nucleotide binding]; other site 680646003861 active site 680646003862 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 680646003863 potential protein location (hypothetical protein) that overlaps protein (ribosome-binding factor A) 680646003864 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 680646003865 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 680646003866 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 680646003867 translation initiation factor IF-2; Region: IF-2; TIGR00487 680646003868 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 680646003869 G1 box; other site 680646003870 putative GEF interaction site [polypeptide binding]; other site 680646003871 GTP/Mg2+ binding site [chemical binding]; other site 680646003872 Switch I region; other site 680646003873 G2 box; other site 680646003874 G3 box; other site 680646003875 Switch II region; other site 680646003876 G4 box; other site 680646003877 G5 box; other site 680646003878 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 680646003879 Translation-initiation factor 2; Region: IF-2; pfam11987 680646003880 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 680646003881 Protein of unknown function (DUF448); Region: DUF448; pfam04296 680646003882 putative RNA binding cleft [nucleotide binding]; other site 680646003883 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 680646003884 NusA N-terminal domain; Region: NusA_N; pfam08529 680646003885 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 680646003886 RNA binding site [nucleotide binding]; other site 680646003887 homodimer interface [polypeptide binding]; other site 680646003888 NusA-like KH domain; Region: KH_5; pfam13184 680646003889 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 680646003890 G-X-X-G motif; other site 680646003891 ribosome maturation protein RimP; Reviewed; Region: PRK00092 680646003892 Sm and related proteins; Region: Sm_like; cl00259 680646003893 heptamer interface [polypeptide binding]; other site 680646003894 Sm1 motif; other site 680646003895 hexamer interface [polypeptide binding]; other site 680646003896 RNA binding site [nucleotide binding]; other site 680646003897 Sm2 motif; other site 680646003898 prolyl-tRNA synthetase; Provisional; Region: PRK09194 680646003899 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 680646003900 dimer interface [polypeptide binding]; other site 680646003901 motif 1; other site 680646003902 active site 680646003903 motif 2; other site 680646003904 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 680646003905 putative deacylase active site [active] 680646003906 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 680646003907 active site 680646003908 motif 3; other site 680646003909 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 680646003910 anticodon binding site; other site 680646003911 Predicted acetyltransferase [General function prediction only]; Region: COG3393 680646003912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 680646003913 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 680646003914 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 680646003915 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 680646003916 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 680646003917 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 680646003918 active site 680646003919 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 680646003920 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 680646003921 putative substrate binding region [chemical binding]; other site 680646003922 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 680646003923 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 680646003924 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 680646003925 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 680646003926 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 680646003927 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 680646003928 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 680646003929 ribosome recycling factor; Reviewed; Region: frr; PRK00083 680646003930 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 680646003931 hinge region; other site 680646003932 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 680646003933 putative nucleotide binding site [chemical binding]; other site 680646003934 uridine monophosphate binding site [chemical binding]; other site 680646003935 homohexameric interface [polypeptide binding]; other site 680646003936 elongation factor Ts; Reviewed; Region: tsf; PRK12332 680646003937 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 680646003938 Elongation factor TS; Region: EF_TS; pfam00889 680646003939 Elongation factor TS; Region: EF_TS; pfam00889 680646003940 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 680646003941 rRNA interaction site [nucleotide binding]; other site 680646003942 S8 interaction site; other site 680646003943 putative laminin-1 binding site; other site 680646003944 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 680646003945 Peptidase family M23; Region: Peptidase_M23; pfam01551 680646003946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 680646003947 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 680646003948 putative ADP-binding pocket [chemical binding]; other site 680646003949 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 680646003950 DNA primase, catalytic core; Region: dnaG; TIGR01391 680646003951 CHC2 zinc finger; Region: zf-CHC2; pfam01807 680646003952 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 680646003953 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 680646003954 active site 680646003955 metal binding site [ion binding]; metal-binding site 680646003956 interdomain interaction site; other site 680646003957 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 680646003958 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 680646003959 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 680646003960 FMN binding site [chemical binding]; other site 680646003961 active site 680646003962 catalytic residues [active] 680646003963 substrate binding site [chemical binding]; other site 680646003964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 680646003965 Coenzyme A binding pocket [chemical binding]; other site 680646003966 glycyl-tRNA synthetase; Provisional; Region: PRK04173 680646003967 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 680646003968 motif 1; other site 680646003969 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 680646003970 active site 680646003971 motif 2; other site 680646003972 motif 3; other site 680646003973 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 680646003974 anticodon binding site; other site 680646003975 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 680646003976 RNA binding surface [nucleotide binding]; other site 680646003977 Predicted esterase [General function prediction only]; Region: COG0400 680646003978 Serine hydrolase (FSH1); Region: FSH1; pfam03959 680646003979 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 680646003980 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 680646003981 DNA binding residues [nucleotide binding] 680646003982 dimer interface [polypeptide binding]; other site 680646003983 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 680646003984 potential protein location (hypothetical protein) that overlaps protein (predicted transcriptional regulator) 680646003985 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 680646003986 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 680646003987 DNA binding residues [nucleotide binding] 680646003988 putative dimer interface [polypeptide binding]; other site 680646003989 potential protein location (hypothetical protein) that overlaps protein (homoserine acetyltransferase) 680646003990 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 680646003991 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 680646003992 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 680646003993 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 680646003994 homodimer interface [polypeptide binding]; other site 680646003995 substrate-cofactor binding pocket; other site 680646003996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646003997 catalytic residue [active] 680646003998 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 680646003999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646004000 ABC transporter signature motif; other site 680646004001 Walker B; other site 680646004002 D-loop; other site 680646004003 H-loop/switch region; other site 680646004004 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 680646004005 GTPase RsgA; Reviewed; Region: PRK01889 680646004006 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 680646004007 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 680646004008 GTPase/Zn-binding domain interface [polypeptide binding]; other site 680646004009 GTP/Mg2+ binding site [chemical binding]; other site 680646004010 G4 box; other site 680646004011 G5 box; other site 680646004012 G1 box; other site 680646004013 Switch I region; other site 680646004014 G2 box; other site 680646004015 G3 box; other site 680646004016 Switch II region; other site 680646004017 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 680646004018 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 680646004019 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 680646004020 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 680646004021 GatB domain; Region: GatB_Yqey; smart00845 680646004022 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 680646004023 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 680646004024 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 680646004025 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 680646004026 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 680646004027 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 680646004028 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 680646004029 nucleotide binding pocket [chemical binding]; other site 680646004030 K-X-D-G motif; other site 680646004031 catalytic site [active] 680646004032 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 680646004033 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 680646004034 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 680646004035 Dimer interface [polypeptide binding]; other site 680646004036 BRCT sequence motif; other site 680646004037 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 680646004038 active site 680646004039 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 680646004040 cyclase homology domain; Region: CHD; cd07302 680646004041 nucleotidyl binding site; other site 680646004042 metal binding site [ion binding]; metal-binding site 680646004043 dimer interface [polypeptide binding]; other site 680646004044 Bacterial PH domain; Region: DUF304; cl01348 680646004045 potential protein location (hypothetical protein) that overlaps protein (ABC-type glucose/galactose transport system, permease component) 680646004046 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 680646004047 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 680646004048 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 680646004049 YCII-related domain; Region: YCII; cl00999 680646004050 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 680646004051 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 680646004052 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 680646004053 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 680646004054 Restriction endonuclease; Region: Mrr_cat; pfam04471 680646004055 Restriction endonuclease; Region: Mrr_cat; pfam04471 680646004056 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 680646004057 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 680646004058 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646004059 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646004060 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 680646004061 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 680646004062 Maf-like protein; Region: Maf; pfam02545 680646004063 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 680646004064 active site 680646004065 dimer interface [polypeptide binding]; other site 680646004066 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 680646004067 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 680646004068 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 680646004069 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 680646004070 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 680646004071 carboxyltransferase (CT) interaction site; other site 680646004072 biotinylation site [posttranslational modification]; other site 680646004073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646004074 metabolite-proton symporter; Region: 2A0106; TIGR00883 680646004075 putative substrate translocation pore; other site 680646004076 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 680646004077 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 680646004078 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 680646004079 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 680646004080 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 680646004081 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 680646004082 ATP binding site [chemical binding]; other site 680646004083 putative Mg++ binding site [ion binding]; other site 680646004084 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 680646004085 nucleotide binding region [chemical binding]; other site 680646004086 ATP-binding site [chemical binding]; other site 680646004087 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 680646004088 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 680646004089 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 680646004090 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 680646004091 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 680646004092 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 680646004093 active site 680646004094 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 680646004095 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 680646004096 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 680646004097 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 680646004098 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 680646004099 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 680646004100 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 680646004101 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 680646004102 active site 680646004103 nucleotide binding site [chemical binding]; other site 680646004104 HIGH motif; other site 680646004105 KMSKS motif; other site 680646004106 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 680646004107 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 680646004108 trimerization site [polypeptide binding]; other site 680646004109 active site 680646004110 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 680646004111 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 680646004112 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 680646004113 catalytic residue [active] 680646004114 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 680646004115 putative active site [active] 680646004116 catalytic residue [active] 680646004117 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 680646004118 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 680646004119 5S rRNA interface [nucleotide binding]; other site 680646004120 CTC domain interface [polypeptide binding]; other site 680646004121 L16 interface [polypeptide binding]; other site 680646004122 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 680646004123 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 680646004124 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 680646004125 NADP binding site [chemical binding]; other site 680646004126 active site 680646004127 putative substrate binding site [chemical binding]; other site 680646004128 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 680646004129 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 680646004130 NAD binding site [chemical binding]; other site 680646004131 substrate binding site [chemical binding]; other site 680646004132 homodimer interface [polypeptide binding]; other site 680646004133 active site 680646004134 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 680646004135 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 680646004136 substrate binding site; other site 680646004137 tetramer interface; other site 680646004138 Chain length determinant protein; Region: Wzz; cl15801 680646004139 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 680646004140 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 680646004141 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 680646004142 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 680646004143 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 680646004144 putative ADP-binding pocket [chemical binding]; other site 680646004145 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 680646004146 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 680646004147 active site 680646004148 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 680646004149 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 680646004150 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 680646004151 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 680646004152 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 680646004153 Acyltransferase family; Region: Acyl_transf_3; pfam01757 680646004154 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 680646004155 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 680646004156 NeuB family; Region: NeuB; pfam03102 680646004157 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 680646004158 NeuB binding interface [polypeptide binding]; other site 680646004159 putative substrate binding site [chemical binding]; other site 680646004160 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 680646004161 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 680646004162 ligand binding site; other site 680646004163 tetramer interface; other site 680646004164 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 680646004165 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 680646004166 trimer interface [polypeptide binding]; other site 680646004167 active site 680646004168 substrate binding site [chemical binding]; other site 680646004169 CoA binding site [chemical binding]; other site 680646004170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 680646004171 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 680646004172 potential protein location (hypothetical protein) that overlaps protein (predicted glycosyltransferase) 680646004173 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 680646004174 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 680646004175 active site 680646004176 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 680646004177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646004178 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 680646004179 Walker A/P-loop; other site 680646004180 ATP binding site [chemical binding]; other site 680646004181 Q-loop/lid; other site 680646004182 ABC transporter signature motif; other site 680646004183 Walker B; other site 680646004184 D-loop; other site 680646004185 H-loop/switch region; other site 680646004186 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 680646004187 Low molecular weight phosphatase family; Region: LMWPc; cl00105 680646004188 active site 680646004189 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 680646004190 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 680646004191 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 680646004192 active site 680646004193 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 680646004194 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 680646004195 Substrate binding site; other site 680646004196 Mg++ binding site; other site 680646004197 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 680646004198 active site 680646004199 substrate binding site [chemical binding]; other site 680646004200 CoA binding site [chemical binding]; other site 680646004201 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 680646004202 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 680646004203 ABC transporter; Region: ABC_tran_2; pfam12848 680646004204 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 680646004205 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 680646004206 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 680646004207 potential protein location (hypothetical protein) that overlaps protein (4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase) 680646004208 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 680646004209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 680646004210 S-adenosylmethionine binding site [chemical binding]; other site 680646004211 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 680646004212 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 680646004213 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 680646004214 active site 680646004215 Predicted methyltransferases [General function prediction only]; Region: COG0313 680646004216 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 680646004217 putative SAM binding site [chemical binding]; other site 680646004218 putative homodimer interface [polypeptide binding]; other site 680646004219 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 680646004220 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 680646004221 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 680646004222 TIGR03089 family protein; Region: TIGR03089 680646004223 Predicted membrane protein [Function unknown]; Region: COG2246 680646004224 GtrA-like protein; Region: GtrA; pfam04138 680646004225 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 680646004226 ATP-grasp domain; Region: ATP-grasp; pfam02222 680646004227 AIR carboxylase; Region: AIRC; pfam00731 680646004228 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 680646004229 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 680646004230 fructose 1,6-bisphosphatase II; Reviewed; Region: glpX; PRK09479 680646004231 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 680646004232 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 680646004233 active site clefts [active] 680646004234 zinc binding site [ion binding]; other site 680646004235 dimer interface [polypeptide binding]; other site 680646004236 fumarate hydratase; Reviewed; Region: fumC; PRK00485 680646004237 Class II fumarases; Region: Fumarase_classII; cd01362 680646004238 active site 680646004239 tetramer interface [polypeptide binding]; other site 680646004240 pyruvate dehydrogenase; Provisional; Region: PRK06546 680646004241 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 680646004242 PYR/PP interface [polypeptide binding]; other site 680646004243 tetramer interface [polypeptide binding]; other site 680646004244 dimer interface [polypeptide binding]; other site 680646004245 TPP binding site [chemical binding]; other site 680646004246 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 680646004247 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 680646004248 TPP-binding site [chemical binding]; other site 680646004249 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 680646004250 nudix motif; other site 680646004251 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 680646004252 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 680646004253 catalytic residue [active] 680646004254 putative FPP diphosphate binding site; other site 680646004255 putative FPP binding hydrophobic cleft; other site 680646004256 dimer interface [polypeptide binding]; other site 680646004257 putative IPP diphosphate binding site; other site 680646004258 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 680646004259 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 680646004260 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 680646004261 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 680646004262 threonine dehydratase; Provisional; Region: PRK08198 680646004263 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 680646004264 tetramer interface [polypeptide binding]; other site 680646004265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646004266 catalytic residue [active] 680646004267 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 680646004268 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 680646004269 Domain of unknown function DUF20; Region: UPF0118; pfam01594 680646004270 Bax inhibitor 1 like; Region: BaxI_1; cl17691 680646004271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 680646004272 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 680646004273 active site 680646004274 motif I; other site 680646004275 motif II; other site 680646004276 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 680646004277 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 680646004278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 680646004279 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 680646004280 active site 680646004281 catalytic residues [active] 680646004282 exopolyphosphatase; Region: exo_poly_only; TIGR03706 680646004283 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 680646004284 Protein of unknown function (DUF501); Region: DUF501; pfam04417 680646004285 Septum formation initiator; Region: DivIC; pfam04977 680646004286 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 680646004287 Core-2/I-Branching enzyme; Region: Branch; pfam02485 680646004288 enolase; Provisional; Region: eno; PRK00077 680646004289 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 680646004290 dimer interface [polypeptide binding]; other site 680646004291 metal binding site [ion binding]; metal-binding site 680646004292 substrate binding pocket [chemical binding]; other site 680646004293 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 680646004294 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 680646004295 homodimer interface [polypeptide binding]; other site 680646004296 metal binding site [ion binding]; metal-binding site 680646004297 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 680646004298 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 680646004299 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 680646004300 metal binding site [ion binding]; metal-binding site 680646004301 putative dimer interface [polypeptide binding]; other site 680646004302 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 680646004303 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 680646004304 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 680646004305 L-aspartate oxidase; Provisional; Region: PRK06175 680646004306 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 680646004307 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 680646004308 putative Iron-sulfur protein interface [polypeptide binding]; other site 680646004309 putative proximal heme binding site [chemical binding]; other site 680646004310 putative SdhC-like subunit interface [polypeptide binding]; other site 680646004311 putative distal heme binding site [chemical binding]; other site 680646004312 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 680646004313 putative Iron-sulfur protein interface [polypeptide binding]; other site 680646004314 putative proximal heme binding site [chemical binding]; other site 680646004315 putative SdhD-like interface [polypeptide binding]; other site 680646004316 putative distal heme binding site [chemical binding]; other site 680646004317 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 680646004318 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 680646004319 Substrate binding site; other site 680646004320 Cupin domain; Region: Cupin_2; cl17218 680646004321 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 680646004322 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 680646004323 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 680646004324 active site 680646004325 HIGH motif; other site 680646004326 dimer interface [polypeptide binding]; other site 680646004327 KMSKS motif; other site 680646004328 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 680646004329 putative active site [active] 680646004330 putative catalytic site [active] 680646004331 putative DNA binding site [nucleotide binding]; other site 680646004332 putative phosphate binding site [ion binding]; other site 680646004333 metal binding site A [ion binding]; metal-binding site 680646004334 putative AP binding site [nucleotide binding]; other site 680646004335 putative metal binding site B [ion binding]; other site 680646004336 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 680646004337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 680646004338 DNA-binding site [nucleotide binding]; DNA binding site 680646004339 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 680646004340 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 680646004341 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 680646004342 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 680646004343 homodimer interface [polypeptide binding]; other site 680646004344 NADP binding site [chemical binding]; other site 680646004345 substrate binding site [chemical binding]; other site 680646004346 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 680646004347 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 680646004348 dimer interface [polypeptide binding]; other site 680646004349 active site 680646004350 glycine-pyridoxal phosphate binding site [chemical binding]; other site 680646004351 folate binding site [chemical binding]; other site 680646004352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 680646004353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 680646004354 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 680646004355 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 680646004356 purine monophosphate binding site [chemical binding]; other site 680646004357 dimer interface [polypeptide binding]; other site 680646004358 putative catalytic residues [active] 680646004359 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 680646004360 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 680646004361 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 680646004362 active site 680646004363 substrate binding site [chemical binding]; other site 680646004364 cosubstrate binding site; other site 680646004365 catalytic site [active] 680646004366 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 680646004367 putative active site [active] 680646004368 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 680646004369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 680646004370 ATP binding site [chemical binding]; other site 680646004371 putative Mg++ binding site [ion binding]; other site 680646004372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 680646004373 nucleotide binding region [chemical binding]; other site 680646004374 ATP-binding site [chemical binding]; other site 680646004375 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 680646004376 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 680646004377 active site 680646004378 catalytic tetrad [active] 680646004379 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 680646004380 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 680646004381 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 680646004382 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 680646004383 RNA binding site [nucleotide binding]; other site 680646004384 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 680646004385 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 680646004386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 680646004387 S-adenosylmethionine binding site [chemical binding]; other site 680646004388 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 680646004389 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 680646004390 DNA binding residues [nucleotide binding] 680646004391 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 680646004392 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 680646004393 HSP70 interaction site [polypeptide binding]; other site 680646004394 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 680646004395 substrate binding site [polypeptide binding]; other site 680646004396 dimer interface [polypeptide binding]; other site 680646004397 GrpE; Region: GrpE; pfam01025 680646004398 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 680646004399 dimer interface [polypeptide binding]; other site 680646004400 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 680646004401 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 680646004402 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 680646004403 nucleotide binding site [chemical binding]; other site 680646004404 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 680646004405 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 680646004406 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 680646004407 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 680646004408 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 680646004409 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 680646004410 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 680646004411 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 680646004412 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 680646004413 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 680646004414 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 680646004415 Low molecular weight phosphatase family; Region: LMWPc; cd00115 680646004416 active site 680646004417 hypothetical protein; Provisional; Region: PRK06547 680646004418 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 680646004419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646004420 putative substrate translocation pore; other site 680646004421 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 680646004422 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 680646004423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646004424 catalytic residue [active] 680646004425 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 680646004426 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 680646004427 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 680646004428 Walker A/P-loop; other site 680646004429 ATP binding site [chemical binding]; other site 680646004430 Q-loop/lid; other site 680646004431 ABC transporter signature motif; other site 680646004432 Walker B; other site 680646004433 D-loop; other site 680646004434 H-loop/switch region; other site 680646004435 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 680646004436 Walker A/P-loop; other site 680646004437 ATP binding site [chemical binding]; other site 680646004438 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 680646004439 Q-loop/lid; other site 680646004440 ABC transporter signature motif; other site 680646004441 Walker B; other site 680646004442 D-loop; other site 680646004443 H-loop/switch region; other site 680646004444 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 680646004445 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 680646004446 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 680646004447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646004448 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 680646004449 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 680646004450 thiamine phosphate binding site [chemical binding]; other site 680646004451 active site 680646004452 pyrophosphate binding site [ion binding]; other site 680646004453 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 680646004454 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 680646004455 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 680646004456 thiS-thiF/thiG interaction site; other site 680646004457 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 680646004458 ThiS interaction site; other site 680646004459 putative active site [active] 680646004460 tetramer interface [polypeptide binding]; other site 680646004461 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 680646004462 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 680646004463 ATP binding site [chemical binding]; other site 680646004464 substrate interface [chemical binding]; other site 680646004465 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 680646004466 active site residue [active] 680646004467 Methylamine utilisation protein MauE; Region: MauE; pfam07291 680646004468 Methyltransferase domain; Region: Methyltransf_31; pfam13847 680646004469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 680646004470 S-adenosylmethionine binding site [chemical binding]; other site 680646004471 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 680646004472 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 680646004473 potential protein location (hypothetical protein) that overlaps protein (uncharacterized membrane protein) 680646004474 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646004475 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646004476 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 680646004477 IHF dimer interface [polypeptide binding]; other site 680646004478 IHF - DNA interface [nucleotide binding]; other site 680646004479 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 680646004480 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 680646004481 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 680646004482 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 680646004483 active site 680646004484 catalytic triad [active] 680646004485 oxyanion hole [active] 680646004486 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 680646004487 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 680646004488 Walker A/P-loop; other site 680646004489 ATP binding site [chemical binding]; other site 680646004490 Q-loop/lid; other site 680646004491 ABC transporter signature motif; other site 680646004492 Walker B; other site 680646004493 D-loop; other site 680646004494 H-loop/switch region; other site 680646004495 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 680646004496 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 680646004497 Thioredoxin; Region: Thioredoxin_4; cl17273 680646004498 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 680646004499 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 680646004500 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 680646004501 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 680646004502 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 680646004503 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 680646004504 active site 680646004505 HIGH motif; other site 680646004506 nucleotide binding site [chemical binding]; other site 680646004507 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 680646004508 KMSKS motif; other site 680646004509 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 680646004510 tRNA binding surface [nucleotide binding]; other site 680646004511 anticodon binding site; other site 680646004512 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 680646004513 homotrimer interaction site [polypeptide binding]; other site 680646004514 zinc binding site [ion binding]; other site 680646004515 CDP-binding sites; other site 680646004516 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 680646004517 substrate binding site; other site 680646004518 dimer interface; other site 680646004519 potential protein location (hypothetical protein) that overlaps protein (response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain) 680646004520 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 680646004521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 680646004522 active site 680646004523 phosphorylation site [posttranslational modification] 680646004524 intermolecular recognition site; other site 680646004525 dimerization interface [polypeptide binding]; other site 680646004526 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 680646004527 DNA binding site [nucleotide binding] 680646004528 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 680646004529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 680646004530 dimer interface [polypeptide binding]; other site 680646004531 phosphorylation site [posttranslational modification] 680646004532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 680646004533 ATP binding site [chemical binding]; other site 680646004534 Mg2+ binding site [ion binding]; other site 680646004535 G-X-G motif; other site 680646004536 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 680646004537 catalytic core [active] 680646004538 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 680646004539 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 680646004540 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 680646004541 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 680646004542 homodimer interface [polypeptide binding]; other site 680646004543 substrate-cofactor binding pocket; other site 680646004544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646004545 catalytic residue [active] 680646004546 thymidylate kinase; Validated; Region: tmk; PRK00698 680646004547 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 680646004548 TMP-binding site; other site 680646004549 ATP-binding site [chemical binding]; other site 680646004550 DNA polymerase III subunit delta'; Validated; Region: PRK07940 680646004551 DNA polymerase III subunit delta'; Validated; Region: PRK08485 680646004552 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 680646004553 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 680646004554 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 680646004555 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 680646004556 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 680646004557 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 680646004558 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 680646004559 active site 680646004560 substrate binding site [chemical binding]; other site 680646004561 metal binding site [ion binding]; metal-binding site 680646004562 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 680646004563 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 680646004564 heme-binding site [chemical binding]; other site 680646004565 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 680646004566 FAD binding pocket [chemical binding]; other site 680646004567 FAD binding motif [chemical binding]; other site 680646004568 phosphate binding motif [ion binding]; other site 680646004569 beta-alpha-beta structure motif; other site 680646004570 NAD binding pocket [chemical binding]; other site 680646004571 Heme binding pocket [chemical binding]; other site 680646004572 Transcriptional regulator; Region: Rrf2; cl17282 680646004573 Rrf2 family protein; Region: rrf2_super; TIGR00738 680646004574 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 680646004575 active site 680646004576 substrate-binding site [chemical binding]; other site 680646004577 metal-binding site [ion binding] 680646004578 GTP binding site [chemical binding]; other site 680646004579 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 680646004580 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 680646004581 catalytic loop [active] 680646004582 iron binding site [ion binding]; other site 680646004583 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 680646004584 potential protein location (hypothetical protein) that overlaps protein (ABC-type antimicrobial peptide transport system, permease component) 680646004585 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 680646004586 putative FMN binding site [chemical binding]; other site 680646004587 DEAD-like helicases superfamily; Region: DEXDc; smart00487 680646004588 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 680646004589 ATP binding site [chemical binding]; other site 680646004590 putative Mg++ binding site [ion binding]; other site 680646004591 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 680646004592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 680646004593 nucleotide binding region [chemical binding]; other site 680646004594 ATP-binding site [chemical binding]; other site 680646004595 DEAD/H associated; Region: DEAD_assoc; pfam08494 680646004596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 680646004597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 680646004598 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 680646004599 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 680646004600 active site 680646004601 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 680646004602 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 680646004603 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 680646004604 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 680646004605 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 680646004606 hydrophobic ligand binding site; other site 680646004607 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646004608 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 680646004609 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 680646004610 active site 680646004611 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 680646004612 Spore germination protein; Region: Spore_permease; cl17796 680646004613 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 680646004614 Spore germination protein; Region: Spore_permease; cl17796 680646004615 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 680646004616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 680646004617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 680646004618 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 680646004619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 680646004620 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 680646004621 Walker A motif; other site 680646004622 ATP binding site [chemical binding]; other site 680646004623 Walker B motif; other site 680646004624 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 680646004625 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 680646004626 recombination protein RecR; Reviewed; Region: recR; PRK00076 680646004627 RecR protein; Region: RecR; pfam02132 680646004628 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 680646004629 putative active site [active] 680646004630 putative metal-binding site [ion binding]; other site 680646004631 tetramer interface [polypeptide binding]; other site 680646004632 aspartate kinase; Reviewed; Region: PRK06635 680646004633 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 680646004634 putative nucleotide binding site [chemical binding]; other site 680646004635 putative catalytic residues [active] 680646004636 putative Mg ion binding site [ion binding]; other site 680646004637 putative aspartate binding site [chemical binding]; other site 680646004638 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 680646004639 putative allosteric regulatory site; other site 680646004640 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 680646004641 putative allosteric regulatory residue; other site 680646004642 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 680646004643 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 680646004644 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 680646004645 putative active site [active] 680646004646 catalytic triad [active] 680646004647 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 680646004648 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 680646004649 dimerization interface [polypeptide binding]; other site 680646004650 ATP binding site [chemical binding]; other site 680646004651 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 680646004652 dimerization interface [polypeptide binding]; other site 680646004653 ATP binding site [chemical binding]; other site 680646004654 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 680646004655 heme binding pocket [chemical binding]; other site 680646004656 heme ligand [chemical binding]; other site 680646004657 Htaa; Region: HtaA; pfam04213 680646004658 Htaa; Region: HtaA; pfam04213 680646004659 Htaa; Region: HtaA; pfam04213 680646004660 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 680646004661 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 680646004662 intersubunit interface [polypeptide binding]; other site 680646004663 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 680646004664 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 680646004665 ABC-ATPase subunit interface; other site 680646004666 dimer interface [polypeptide binding]; other site 680646004667 putative PBP binding regions; other site 680646004668 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 680646004669 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 680646004670 Walker A/P-loop; other site 680646004671 ATP binding site [chemical binding]; other site 680646004672 Q-loop/lid; other site 680646004673 ABC transporter signature motif; other site 680646004674 Walker B; other site 680646004675 D-loop; other site 680646004676 H-loop/switch region; other site 680646004677 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 680646004678 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 680646004679 Soluble P-type ATPase [General function prediction only]; Region: COG4087 680646004680 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 680646004681 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 680646004682 active site turn [active] 680646004683 phosphorylation site [posttranslational modification] 680646004684 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 680646004685 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 680646004686 HPr interaction site; other site 680646004687 glycerol kinase (GK) interaction site [polypeptide binding]; other site 680646004688 active site 680646004689 phosphorylation site [posttranslational modification] 680646004690 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 680646004691 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 680646004692 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 680646004693 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 680646004694 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 680646004695 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 680646004696 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 680646004697 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 680646004698 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 680646004699 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 680646004700 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 680646004701 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 680646004702 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 680646004703 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 680646004704 Walker A/P-loop; other site 680646004705 ATP binding site [chemical binding]; other site 680646004706 Q-loop/lid; other site 680646004707 ABC transporter signature motif; other site 680646004708 Walker B; other site 680646004709 D-loop; other site 680646004710 H-loop/switch region; other site 680646004711 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 680646004712 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 680646004713 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 680646004714 Walker A/P-loop; other site 680646004715 ATP binding site [chemical binding]; other site 680646004716 Q-loop/lid; other site 680646004717 ABC transporter signature motif; other site 680646004718 Walker B; other site 680646004719 D-loop; other site 680646004720 H-loop/switch region; other site 680646004721 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 680646004722 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 680646004723 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 680646004724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 680646004725 dimer interface [polypeptide binding]; other site 680646004726 conserved gate region; other site 680646004727 putative PBP binding loops; other site 680646004728 ABC-ATPase subunit interface; other site 680646004729 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 680646004730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 680646004731 dimer interface [polypeptide binding]; other site 680646004732 conserved gate region; other site 680646004733 putative PBP binding loops; other site 680646004734 ABC-ATPase subunit interface; other site 680646004735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646004736 Major Facilitator Superfamily; Region: MFS_1; pfam07690 680646004737 putative substrate translocation pore; other site 680646004738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646004739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 680646004740 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 680646004741 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 680646004742 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 680646004743 putative active site [active] 680646004744 catalytic site [active] 680646004745 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 680646004746 putative active site [active] 680646004747 catalytic site [active] 680646004748 Uncharacterized conserved protein [Function unknown]; Region: COG1434 680646004749 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 680646004750 putative active site [active] 680646004751 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 680646004752 RNA/DNA hybrid binding site [nucleotide binding]; other site 680646004753 active site 680646004754 Uncharacterized conserved protein [Function unknown]; Region: COG1359 680646004755 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 680646004756 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 680646004757 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 680646004758 Ca binding site [ion binding]; other site 680646004759 active site 680646004760 catalytic site [active] 680646004761 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 680646004762 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 680646004763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 680646004764 ABC-ATPase subunit interface; other site 680646004765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 680646004766 dimer interface [polypeptide binding]; other site 680646004767 conserved gate region; other site 680646004768 putative PBP binding loops; other site 680646004769 ABC-ATPase subunit interface; other site 680646004770 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 680646004771 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 680646004772 Walker A/P-loop; other site 680646004773 ATP binding site [chemical binding]; other site 680646004774 Q-loop/lid; other site 680646004775 ABC transporter signature motif; other site 680646004776 Walker B; other site 680646004777 D-loop; other site 680646004778 H-loop/switch region; other site 680646004779 light-independent protochlorophyllide reductase, B subunit; Region: DPOR_BchB; TIGR01278 680646004780 ferredoxin-NADP+ reductase; Region: PLN02852 680646004781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 680646004782 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 680646004783 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 680646004784 potential protein location (hypothetical protein) that overlaps protein (permease) 680646004785 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 680646004786 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 680646004787 hypothetical protein; Provisional; Region: PRK01842 680646004788 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 680646004789 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 680646004790 active site 680646004791 non-prolyl cis peptide bond; other site 680646004792 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 680646004793 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 680646004794 Walker A/P-loop; other site 680646004795 ATP binding site [chemical binding]; other site 680646004796 Q-loop/lid; other site 680646004797 ABC transporter signature motif; other site 680646004798 Walker B; other site 680646004799 D-loop; other site 680646004800 H-loop/switch region; other site 680646004801 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 680646004802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 680646004803 substrate binding pocket [chemical binding]; other site 680646004804 membrane-bound complex binding site; other site 680646004805 potential protein location (hypothetical protein) that overlaps protein (ABC-type nitrate/sulfonate/bicarbonate transport system, permease component) 680646004806 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 680646004807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 680646004808 dimer interface [polypeptide binding]; other site 680646004809 conserved gate region; other site 680646004810 putative PBP binding loops; other site 680646004811 ABC-ATPase subunit interface; other site 680646004812 acetyl-CoA synthetase; Provisional; Region: PRK00174 680646004813 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 680646004814 acyl-activating enzyme (AAE) consensus motif; other site 680646004815 AMP binding site [chemical binding]; other site 680646004816 active site 680646004817 CoA binding site [chemical binding]; other site 680646004818 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 680646004819 active site 680646004820 potential protein location (hypothetical protein) that overlaps protein (exonuclease III) 680646004821 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 680646004822 NADH(P)-binding; Region: NAD_binding_10; pfam13460 680646004823 NAD(P) binding site [chemical binding]; other site 680646004824 putative active site [active] 680646004825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646004826 putative substrate translocation pore; other site 680646004827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646004828 Acylphosphatase; Region: Acylphosphatase; cl00551 680646004829 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 680646004830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 680646004831 potential protein location (hypothetical protein) that overlaps protein (uncharacterized conserved protein) 680646004832 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 680646004833 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 680646004834 dimer interface [polypeptide binding]; other site 680646004835 decamer (pentamer of dimers) interface [polypeptide binding]; other site 680646004836 catalytic triad [active] 680646004837 peroxidatic and resolving cysteines [active] 680646004838 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 680646004839 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 680646004840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646004841 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 680646004842 putative substrate translocation pore; other site 680646004843 UPF0126 domain; Region: UPF0126; pfam03458 680646004844 Predicted membrane protein [Function unknown]; Region: COG2860 680646004845 UPF0126 domain; Region: UPF0126; pfam03458 680646004846 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 680646004847 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 680646004848 Walker A/P-loop; other site 680646004849 ATP binding site [chemical binding]; other site 680646004850 Q-loop/lid; other site 680646004851 ABC transporter signature motif; other site 680646004852 Walker B; other site 680646004853 D-loop; other site 680646004854 H-loop/switch region; other site 680646004855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 680646004856 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 680646004857 dimer interface [polypeptide binding]; other site 680646004858 conserved gate region; other site 680646004859 putative PBP binding loops; other site 680646004860 ABC-ATPase subunit interface; other site 680646004861 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 680646004862 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 680646004863 substrate binding pocket [chemical binding]; other site 680646004864 membrane-bound complex binding site; other site 680646004865 hinge residues; other site 680646004866 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 680646004867 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 680646004868 substrate binding pocket [chemical binding]; other site 680646004869 membrane-bound complex binding site; other site 680646004870 hinge residues; other site 680646004871 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 680646004872 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 680646004873 homodimer interface [polypeptide binding]; other site 680646004874 substrate-cofactor binding pocket; other site 680646004875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646004876 catalytic residue [active] 680646004877 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 680646004878 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 680646004879 homodimer interface [polypeptide binding]; other site 680646004880 substrate-cofactor binding pocket; other site 680646004881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646004882 catalytic residue [active] 680646004883 Abi-like protein; Region: Abi_2; pfam07751 680646004884 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 680646004885 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 680646004886 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 680646004887 homodimer interface [polypeptide binding]; other site 680646004888 substrate-cofactor binding pocket; other site 680646004889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 680646004890 catalytic residue [active] 680646004891 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 680646004892 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 680646004893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 680646004894 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 680646004895 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 680646004896 siderophore binding site; other site 680646004897 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 680646004898 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 680646004899 ABC-ATPase subunit interface; other site 680646004900 dimer interface [polypeptide binding]; other site 680646004901 putative PBP binding regions; other site 680646004902 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 680646004903 ABC-ATPase subunit interface; other site 680646004904 dimer interface [polypeptide binding]; other site 680646004905 putative PBP binding regions; other site 680646004906 potential protein location (hypothetical protein) that overlaps protein (integrase) 680646004907 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 680646004908 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 680646004909 oligomer interface [polypeptide binding]; other site 680646004910 metal binding site [ion binding]; metal-binding site 680646004911 metal binding site [ion binding]; metal-binding site 680646004912 putative Cl binding site [ion binding]; other site 680646004913 basic sphincter; other site 680646004914 hydrophobic gate; other site 680646004915 periplasmic entrance; other site 680646004916 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 680646004917 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 680646004918 GDP-binding site [chemical binding]; other site 680646004919 ACT binding site; other site 680646004920 IMP binding site; other site 680646004921 Tic20-like protein; Region: Tic20; pfam09685 680646004922 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 680646004923 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 680646004924 active site 680646004925 catalytic residues [active] 680646004926 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 680646004927 PA/protease or protease-like domain interface [polypeptide binding]; other site 680646004928 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 680646004929 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 680646004930 S-layer homology domain; Region: SLH; pfam00395 680646004931 S-layer homology domain; Region: SLH; pfam00395 680646004932 S-layer homology domain; Region: SLH; pfam00395 680646004933 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 680646004934 putative active site [active] 680646004935 catalytic triad [active] 680646004936 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 680646004937 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 680646004938 S-layer homology domain; Region: SLH; pfam00395 680646004939 S-layer homology domain; Region: SLH; pfam00395 680646004940 S-layer homology domain; Region: SLH; pfam00395 680646004941 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 680646004942 putative active site [active] 680646004943 catalytic triad [active] 680646004944 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 680646004945 PA/protease or protease-like domain interface [polypeptide binding]; other site 680646004946 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 680646004947 catalytic residues [active] 680646004948 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 680646004949 S-layer homology domain; Region: SLH; pfam00395 680646004950 S-layer homology domain; Region: SLH; pfam00395 680646004951 S-layer homology domain; Region: SLH; pfam00395 680646004952 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 680646004953 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 680646004954 homodimer interface [polypeptide binding]; other site 680646004955 NAD binding pocket [chemical binding]; other site 680646004956 ATP binding pocket [chemical binding]; other site 680646004957 Mg binding site [ion binding]; other site 680646004958 active-site loop [active] 680646004959 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 680646004960 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 680646004961 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 680646004962 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 680646004963 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 680646004964 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 680646004965 active site 680646004966 multimer interface [polypeptide binding]; other site 680646004967 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 680646004968 predicted active site [active] 680646004969 catalytic triad [active] 680646004970 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 680646004971 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 680646004972 active site 680646004973 metal binding site [ion binding]; metal-binding site 680646004974 CAAX protease self-immunity; Region: Abi; pfam02517 680646004975 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 680646004976 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 680646004977 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 680646004978 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 680646004979 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 680646004980 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 680646004981 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 680646004982 N-acetyl-D-glucosamine binding site [chemical binding]; other site 680646004983 catalytic residue [active] 680646004984 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 680646004985 Cytochrome P450; Region: p450; cl12078 680646004986 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 680646004987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646004988 putative substrate translocation pore; other site 680646004989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646004990 potential protein location (hypothetical protein) that overlaps protein (predicted oxidoreductase) 680646004991 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 680646004992 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 680646004993 active site 680646004994 catalytic tetrad [active] 680646004995 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 680646004996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646004997 Walker A/P-loop; other site 680646004998 ATP binding site [chemical binding]; other site 680646004999 Q-loop/lid; other site 680646005000 ABC transporter signature motif; other site 680646005001 Walker B; other site 680646005002 D-loop; other site 680646005003 H-loop/switch region; other site 680646005004 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 680646005005 FAD binding site [chemical binding]; other site 680646005006 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 680646005007 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 680646005008 THF binding site; other site 680646005009 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 680646005010 substrate binding site [chemical binding]; other site 680646005011 THF binding site; other site 680646005012 zinc-binding site [ion binding]; other site 680646005013 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 680646005014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646005015 putative substrate translocation pore; other site 680646005016 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 680646005017 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 680646005018 active site 680646005019 Zn binding site [ion binding]; other site 680646005020 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cd01391 680646005021 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 680646005022 phosphopeptide binding site; other site 680646005023 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 680646005024 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 680646005025 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 680646005026 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 680646005027 Catalytic domain of Protein Kinases; Region: PKc; cd00180 680646005028 active site 680646005029 ATP binding site [chemical binding]; other site 680646005030 substrate binding site [chemical binding]; other site 680646005031 activation loop (A-loop); other site 680646005032 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 680646005033 RHS Repeat; Region: RHS_repeat; pfam05593 680646005034 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 680646005035 RHS Repeat; Region: RHS_repeat; cl11982 680646005036 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 680646005037 RHS Repeat; Region: RHS_repeat; pfam05593 680646005038 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 680646005039 Proteins of 100 residues with WXG; Region: WXG100; cl02005 680646005040 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 680646005041 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 680646005042 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 680646005043 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 680646005044 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 680646005045 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 680646005046 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 680646005047 intersubunit interface [polypeptide binding]; other site 680646005048 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 680646005049 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 680646005050 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 680646005051 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 680646005052 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 680646005053 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 680646005054 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 680646005055 ABC-ATPase subunit interface; other site 680646005056 dimer interface [polypeptide binding]; other site 680646005057 putative PBP binding regions; other site 680646005058 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 680646005059 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 680646005060 catalytic Zn binding site [ion binding]; other site 680646005061 structural Zn binding site [ion binding]; other site 680646005062 NAD(P) binding site [chemical binding]; other site 680646005063 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 680646005064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 680646005065 putative substrate translocation pore; other site 680646005066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 680646005067 Uncharacterized conserved protein [Function unknown]; Region: COG1359 680646005068 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 680646005069 nudix motif; other site 680646005070 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 680646005071 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 680646005072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646005073 Walker A/P-loop; other site 680646005074 ATP binding site [chemical binding]; other site 680646005075 Q-loop/lid; other site 680646005076 ABC transporter signature motif; other site 680646005077 Walker B; other site 680646005078 D-loop; other site 680646005079 H-loop/switch region; other site 680646005080 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 680646005081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 680646005082 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 680646005083 Walker A/P-loop; other site 680646005084 ATP binding site [chemical binding]; other site 680646005085 Q-loop/lid; other site 680646005086 ABC transporter signature motif; other site 680646005087 Walker B; other site 680646005088 D-loop; other site 680646005089 H-loop/switch region; other site 680646005090 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 680646005091 AAA domain; Region: AAA_21; pfam13304 680646005092 ABC transporter; Region: ABC_tran; pfam00005 680646005093 Divergent AAA domain; Region: AAA_4; pfam04326 680646005094 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 680646005095 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 680646005096 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 680646005097 putative DNA binding site [nucleotide binding]; other site 680646005098 putative Zn2+ binding site [ion binding]; other site 680646005099 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 680646005100 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 680646005101 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 680646005102 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 680646005103 MarR family; Region: MarR; pfam01047 680646005104 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 680646005105 Ferritin-like domain; Region: Ferritin; pfam00210 680646005106 ferroxidase diiron center [ion binding]; other site 680646005107 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 680646005108 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 680646005109 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 680646005110 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 680646005111 dimer interface [polypeptide binding]; other site 680646005112 putative anticodon binding site; other site 680646005113 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 680646005114 motif 1; other site 680646005115 dimer interface [polypeptide binding]; other site 680646005116 active site 680646005117 motif 2; other site 680646005118 motif 3; other site 680646005119 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 680646005120 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 680646005121 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 680646005122 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 680646005123 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 680646005124 phosphopeptide binding site; other site 680646005125 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 680646005126 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 680646005127 phosphopeptide binding site; other site 680646005128 Protein phosphatase 2C; Region: PP2C; pfam00481 680646005129 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 680646005130 active site 680646005131 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 680646005132 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 680646005133 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 680646005134 Catalytic domain of Protein Kinases; Region: PKc; cd00180 680646005135 active site 680646005136 ATP binding site [chemical binding]; other site 680646005137 substrate binding site [chemical binding]; other site 680646005138 activation loop (A-loop); other site 680646005139 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 680646005140 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 680646005141 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 680646005142 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 680646005143 active site 680646005144 ATP binding site [chemical binding]; other site 680646005145 substrate binding site [chemical binding]; other site 680646005146 activation loop (A-loop); other site 680646005147 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 680646005148 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 680646005149 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 680646005150 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 680646005151 Glutamine amidotransferase class-I; Region: GATase; pfam00117 680646005152 glutamine binding [chemical binding]; other site 680646005153 catalytic triad [active] 680646005154 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 680646005155 active site 680646005156 catalytic site [active] 680646005157 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 680646005158 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 680646005159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 680646005160 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 680646005161 dimerization interface [polypeptide binding]; other site 680646005162 LysE type translocator; Region: LysE; cl00565 680646005163 potential protein location (hypothetical protein) that overlaps protein (D-mannonate dehydratase) 680646005164 replicative DNA helicase; Region: DnaB; TIGR00665 680646005165 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 680646005166 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 680646005167 Walker A motif; other site 680646005168 ATP binding site [chemical binding]; other site 680646005169 Walker B motif; other site 680646005170 DNA binding loops [nucleotide binding] 680646005171 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 680646005172 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 680646005173 homodimer interface [polypeptide binding]; other site 680646005174 active site 680646005175 TDP-binding site; other site 680646005176 Methyltransferase domain; Region: Methyltransf_31; pfam13847 680646005177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 680646005178 S-adenosylmethionine binding site [chemical binding]; other site 680646005179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 680646005180 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 680646005181 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 680646005182 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 680646005183 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 680646005184 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 680646005185 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 680646005186 dimer interface [polypeptide binding]; other site 680646005187 ssDNA binding site [nucleotide binding]; other site 680646005188 tetramer (dimer of dimers) interface [polypeptide binding]; other site 680646005189 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 680646005190 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 680646005191 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 680646005192 active site 680646005193 NTP binding site [chemical binding]; other site 680646005194 metal binding triad [ion binding]; metal-binding site 680646005195 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 680646005196 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 680646005197 Zn2+ binding site [ion binding]; other site 680646005198 Mg2+ binding site [ion binding]; other site 680646005199 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 680646005200 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 680646005201 active site 680646005202 Ap6A binding site [chemical binding]; other site 680646005203 nudix motif; other site 680646005204 metal binding site [ion binding]; metal-binding site 680646005205 integral membrane protein MviN; Region: mviN; TIGR01695 680646005206 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 680646005207 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 680646005208 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 680646005209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 680646005210 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 680646005211 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 680646005212 catalytic residues [active] 680646005213 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 680646005214 ParB-like nuclease domain; Region: ParBc; pfam02195 680646005215 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 680646005216 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 680646005217 P-loop; other site 680646005218 Magnesium ion binding site [ion binding]; other site 680646005219 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 680646005220 Magnesium ion binding site [ion binding]; other site 680646005221 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 680646005222 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 680646005223 potential protein location (hypothetical protein) that overlaps protein (predicted RNA-binding protein) 680646005224 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 680646005225 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 680646005226 G-X-X-G motif; other site 680646005227 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 680646005228 RxxxH motif; other site 680646005229 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 680646005230 Haemolytic domain; Region: Haemolytic; pfam01809 680646005231 Ribonuclease P; Region: Ribonuclease_P; pfam00825 680646005232 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399